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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:acyl donor
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Accession:CHEBI:62049 term browser browse the term
Definition:Any donor that can transfer acyl groups between molecular entities.
Synonyms:xref: PMID:16100120;   PMID:19052863



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acetoacetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD17B2 hydroxysteroid 17-beta dehydrogenase 2 affects binding EXP acetoacetyl CoA binds to HSD17B2 protein CTD PMID:25526675 NCBI chr16:82,035,253...82,098,534
Ensembl chr16:82,035,004...82,098,534
JBrowse link
acetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACLY ATP citrate lyase increases abundance ISO ACLY protein results in increased abundance of Acetyl Coenzyme A CTD PMID:28077572 NCBI chr17:41,866,916...41,930,542
Ensembl chr17:41,866,917...41,930,542
JBrowse link
G APP amyloid beta precursor protein affects localization
increases secretion
multiple interactions
ISO
EXP
APP protein affects the localization of Acetyl Coenzyme A
Acetyl Coenzyme A results in increased secretion of APP protein modified form
Acetyl Coenzyme A inhibits the reaction [Hydrogen Peroxide results in decreased secretion of APP protein modified form]
IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A]
CTD PMID:16122837 PMID:22906069 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G CRAT carnitine O-acetyltransferase decreases activity ISO Acetyl Coenzyme A deficiency results in decreased activity of CRAT protein CTD PMID:8075222 NCBI chr 9:129,094,794...129,110,793
Ensembl chr 9:129,094,142...129,111,189
JBrowse link
G ERCC6 ERCC excision repair 6, chromatin remodeling factor decreases abundance
multiple interactions
EXP ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A
3-Hydroxybutyric Acid inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [ERCC6 gene mutant form results in decreased abundance of Acetyl Coenzyme A]
CTD PMID:25440059 NCBI chr10:49,434,881...49,539,538
Ensembl chr10:49,454,168...49,539,538
JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO IL1B protein affects the reaction [APP protein affects the localization of Acetyl Coenzyme A] CTD PMID:16122837 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G KAT2B lysine acetyltransferase 2B affects binding ISO Acetyl Coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 3:20,040,407...20,154,404
Ensembl chr 3:20,040,446...20,154,404
JBrowse link
G METRNL meteorin like, glial cell differentiation regulator multiple interactions ISO METRNL protein inhibits the reaction [Dietary Fats results in decreased abundance of Acetyl Coenzyme A] CTD PMID:30213948 NCBI chr17:83,079,609...83,095,122
Ensembl chr17:83,079,609...83,095,122
JBrowse link
G NAT1 N-acetyltransferase 1 multiple interactions
affects binding
EXP [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone; Acetyl Coenzyme A inhibits the reaction [Cyanamide results in decreased activity of NAT1 protein]; Acetyl Coenzyme A inhibits the reaction [Iodoacetamide results in decreased activity of NAT1 protein]
Acetyl Coenzyme A binds to NAT1 protein
CTD PMID:20545351 PMID:22835378 NCBI chr 8:18,170,419...18,223,689
Ensembl chr 8:18,170,477...18,223,689
JBrowse link
G NAT2 N-acetyltransferase 2 multiple interactions EXP [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr 8:18,386,585...18,401,219
Ensembl chr 8:18,391,282...18,401,218
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[NQO1 protein co-treated with NADP] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone]; [NQO1 protein co-treated with NADP co-treated with Acetyl Coenzyme A co-treated with NAT1 protein] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone CTD PMID:20545351 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G SULT1A2 sulfotransferase family 1A member 2 multiple interactions EXP [NAT2 protein co-treated with Acetyl Coenzyme A] promotes the reaction [[SULT1A2 protein co-treated with Phosphoadenosine Phosphosulfate] results in increased activity of and results in increased reduction of 3-nitrobenzanthrone] CTD PMID:20545351 NCBI chr16:28,591,943...28,597,070
Ensembl chr16:28,591,943...28,597,050
JBrowse link
acryloyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ECHS1 enoyl-CoA hydratase, short chain 1 increases abundance EXP ECHS1 gene mutant form results in increased abundance of acryloyl-coenzyme A CTD PMID:25125611 NCBI chr10:133,362,480...133,373,396
Ensembl chr10:133,362,485...133,373,354
JBrowse link
G HIBCH 3-hydroxyisobutyryl-CoA hydrolase increases abundance EXP HIBCH gene mutant form results in increased abundance of acryloyl-coenzyme A CTD PMID:25125611 NCBI chr 2:190,203,920...190,319,826
Ensembl chr 2:190,189,735...190,344,193
JBrowse link
arachidonoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP arachidonyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
butyryl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KAT2B lysine acetyltransferase 2B affects binding ISO butyryl-coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 3:20,040,407...20,154,404
Ensembl chr 3:20,040,446...20,154,404
JBrowse link
decanoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSDL2 hydroxysteroid dehydrogenase like 2 multiple interactions EXP [decanoyl-coenzyme A co-treated with NADP] binds to HSDL2 protein CTD PMID:25526675 NCBI chr 9:112,380,052...112,472,410
Ensembl chr 9:112,380,080...112,472,405
JBrowse link
G PECR peroxisomal trans-2-enoyl-CoA reductase multiple interactions EXP [decanoyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 2:216,031,656...216,081,843
Ensembl chr 2:215,996,329...216,082,955
JBrowse link
glutaryl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOT4 acyl-CoA thioesterase 4 affects hydrolysis ISO ACOT4 protein affects the hydrolysis of glutaryl-coenzyme A CTD PMID:16141203 NCBI chr14:73,591,873...73,595,766
Ensembl chr14:73,591,873...73,595,766
JBrowse link
G ACOT8 acyl-CoA thioesterase 8 affects hydrolysis ISO ACOT8 protein affects the hydrolysis of glutaryl-coenzyme A CTD PMID:16141203 NCBI chr20:45,841,721...45,857,405
Ensembl chr20:45,841,721...45,857,405
JBrowse link
hexanoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PECR peroxisomal trans-2-enoyl-CoA reductase multiple interactions EXP [hexanoyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 2:216,031,656...216,081,843
Ensembl chr 2:215,996,329...216,082,955
JBrowse link
isobutyryl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KAT2B lysine acetyltransferase 2B affects binding ISO isobutyryl-coenzyme A binds to KAT2B protein CTD PMID:28077572 NCBI chr 3:20,040,407...20,154,404
Ensembl chr 3:20,040,446...20,154,404
JBrowse link
lauroyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTA1 glutathione S-transferase alpha 1 multiple interactions EXP lauroyl-coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G HSDL2 hydroxysteroid dehydrogenase like 2 multiple interactions EXP [lauroyl-coenzyme A co-treated with NADP] binds to HSDL2 protein CTD PMID:25526675 NCBI chr 9:112,380,052...112,472,410
Ensembl chr 9:112,380,080...112,472,405
JBrowse link
G PECR peroxisomal trans-2-enoyl-CoA reductase multiple interactions EXP [lauroyl-coenzyme A co-treated with NADP] binds to PECR protein CTD PMID:25526675 NCBI chr 2:216,031,656...216,081,843
Ensembl chr 2:215,996,329...216,082,955
JBrowse link
malonyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MLYCD malonyl-CoA decarboxylase multiple interactions ISO PPARA protein promotes the reaction [MLYCD protein results in decreased abundance of Malonyl Coenzyme A] CTD PMID:14641110 NCBI chr16:83,899,115...83,927,031
Ensembl chr16:83,899,115...83,951,445
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions ISO PPARA protein promotes the reaction [MLYCD protein results in decreased abundance of Malonyl Coenzyme A] CTD PMID:14641110 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
methacrylyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ECHS1 enoyl-CoA hydratase, short chain 1 increases abundance EXP ECHS1 gene mutant form results in increased abundance of methacrylyl-coenzyme A CTD PMID:25125611 NCBI chr10:133,362,480...133,373,396
Ensembl chr10:133,362,485...133,373,354
JBrowse link
G HIBCH 3-hydroxyisobutyryl-CoA hydrolase increases abundance EXP HIBCH gene mutant form results in increased abundance of methacrylyl-coenzyme A CTD PMID:25125611 NCBI chr 2:190,203,920...190,319,826
Ensembl chr 2:190,189,735...190,344,193
JBrowse link
myristoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DBI diazepam binding inhibitor, acyl-CoA binding protein affects binding EXP S-tetradecanoyl-coenzyme A binds to DBI protein CTD PMID:17044054 NCBI chr 2:119,366,977...119,372,543
Ensembl chr 2:119,366,924...119,372,550
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions EXP S-tetradecanoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP S-tetradecanoyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
oleoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTA1 glutathione S-transferase alpha 1 multiple interactions EXP oleoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP oleoyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP oleoyl-coenzyme A binds to and results in increased activity of PPARG protein CTD PMID:11139385 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
palmitoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOX1 acyl-CoA oxidase 1 increases metabolic processing
multiple interactions
ISO ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A
[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide; benz(a)anthracene promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]; Dehydroepiandrosterone promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]; Tetrachlorodibenzodioxin promotes the reaction [[ACOX1 protein results in increased metabolism of Palmitoyl Coenzyme A] which results in increased chemical synthesis of Hydrogen Peroxide]
CTD PMID:10497882 NCBI chr17:75,941,507...75,979,199
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G CES1 carboxylesterase 1 increases hydrolysis ISO CES1 protein results in increased hydrolysis of Palmitoyl Coenzyme A CTD PMID:8611161 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A multiple interactions ISO valproyl-coenzyme A inhibits the reaction [CPT1A protein results in increased metabolism of Palmitoyl Coenzyme A] CTD PMID:19854160 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G DGAT1 diacylglycerol O-acyltransferase 1 multiple interactions EXP DGAT1 protein results in increased metabolism of [Palmitoyl Coenzyme A co-treated with Vitamin A] CTD PMID:16214399 NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions EXP Palmitoyl Coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha decreases expression EXP Palmitoyl Coenzyme A results in decreased expression of HNF4A mRNA; Palmitoyl Coenzyme A results in decreased expression of HNF4A protein CTD PMID:17992261 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,700...44,434,596
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP
ISO
Palmitoyl Coenzyme A binds to and results in increased activity of PPARA protein
Acetylglucosamine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atorvastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Atropine inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Budesonide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Enalapril inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Fenofibrate promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gamma-Aminobutyric Acid inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; gedunin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]; Pravastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Pyrazinamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Saccharin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; salicylamide inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolazoline inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]; Tolmetin inhibits the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]
CTD PMID:11139385 PMID:18812576 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP Palmitoyl Coenzyme A binds to and results in increased activity of PPARG protein CTD PMID:11139385 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
G SHBG sex hormone binding globulin decreases expression EXP Palmitoyl Coenzyme A results in decreased expression of SHBG mRNA; Palmitoyl Coenzyme A results in decreased expression of SHBG protein CTD PMID:17992261 NCBI chr17:7,614,064...7,633,372
Ensembl chr17:7,613,946...7,633,382
JBrowse link
stearoyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTA1 glutathione S-transferase alpha 1 multiple interactions EXP stearoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein CTD PMID:10542059 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP stearoyl-coenzyme A binds to and results in increased activity of PPARA protein CTD PMID:11139385 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP stearoyl-coenzyme A binds to and results in increased activity of PPARG protein CTD PMID:11139385 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356
JBrowse link
succinyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACOT4 acyl-CoA thioesterase 4 affects hydrolysis ISO ACOT4 protein affects the hydrolysis of succinyl-coenzyme A CTD PMID:16141203 NCBI chr14:73,591,873...73,595,766
Ensembl chr14:73,591,873...73,595,766
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 25125
    role 25049
      chemical role 23230
        donor 22479
          acyl donor 29
            acetyl-CoA + 11
            acyl-CoA + 29
paths to the root