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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(S)-thalidomide
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Accession:CHEBI:61918 term browser browse the term
Definition:A 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione that has S-configuration at the chiral centre.
Synonyms:exact_synonym: 2-[(3S)-2,6-dioxopiperidin-3-yl]-1H-isoindole-1,3(2H)-dione
 related_synonym: (-)-thalidomide;   Formula=C13H10N2O4;   InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)/t9-/m0/s1;   InChIKey=UEJJHQNACJXSKW-VIFPVBQESA-N;   L-thalidomide;   SMILES=O=C1CC[C@H](N2C(=O)c3ccccc3C2=O)C(=O)N1
 xref: CAS:841-67-8;   Reaxys:5756816
 cyclic_relationship: is_enantiomer_of CHEBI:61917

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pomalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brd4 bromodomain containing 4 multiple interactions ISO pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] CTD PMID:26051217 NCBI chr 7:14,222,101...14,303,055
Ensembl chr 7:14,222,101...14,303,055 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP3 protein CTD PMID:29928335 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein CTD PMID:29928335 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO pomalidomide results in increased secretion of CCL2 protein CTD PMID:15292067 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO pomalidomide results in increased expression of CEBPA mRNA CTD PMID:15292067 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO pomalidomide results in increased expression of CEBPD mRNA CTD PMID:15292067 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146 		JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon increases expression ISO pomalidomide results in increased expression of CEBPE mRNA CTD PMID:15292067 NCBI chr15:33,356,119...33,357,517
Ensembl chr15:33,355,947...33,358,138 		JBrowse link
G Crbn cereblon multiple interactions
affects binding
increases response to substance		 ISO [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in increased expression of CRBN protein; [pomalidomide co-treated with Dexamethasone] results in increased expression of CRBN protein; pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
pomalidomide binds to [SALL4 protein binds to CRBN protein]
CRBN results in increased susceptibility to pomalidomide		 CTD PMID:25043012 PMID:26186254 PMID:29928335 PMID:30067223 NCBI chr 4:138,864,910...138,885,786
Ensembl chr 4:138,866,761...138,885,556 		JBrowse link
G Csf2 colony stimulating factor 2 decreases secretion ISO pomalidomide results in decreased secretion of CSF2 protein CTD PMID:15292067 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Csf3 colony stimulating factor 3 increases secretion ISO pomalidomide results in increased secretion of CSF3 protein CTD PMID:15292067 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases oxidation ISO CYP2C19 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases oxidation ISO CYP2J2 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases oxidation ISO CYP3A4 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Dtwd1 DTW domain containing 1 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of DTWD1 protein CTD PMID:30067223 NCBI chr 3:118,427,790...118,443,003
Ensembl chr 3:118,430,511...118,442,098 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:29928335 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248 		JBrowse link
G Fam83f family with sequence similarity 83, member F multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of FAM83F protein CTD PMID:30067223 NCBI chr 7:121,889,157...121,918,772
Ensembl chr 7:121,889,157...121,918,772 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO pomalidomide results in decreased expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 affects expression ISO pomalidomide affects the expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein; afuresertib affects the reaction [[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein] CTD PMID:29928335 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016 		JBrowse link
G Gata1 GATA binding protein 1 decreases expression ISO pomalidomide results in decreased expression of GATA1 mRNA; pomalidomide results in decreased expression of GATA1 protein CTD PMID:15292067 NCBI chr  X:15,273,937...15,281,759
Ensembl chr  X:15,378,789...15,382,066 		JBrowse link
G Gata2 GATA binding protein 2 decreases expression ISO pomalidomide results in decreased expression of GATA2 mRNA CTD PMID:15292067 NCBI chr 4:120,129,028...120,142,490
Ensembl chr 4:120,133,713...120,142,488 		JBrowse link
G Gfi1 growth factor independent 1 transcriptional repressor increases expression ISO pomalidomide results in increased expression of GFI1 mRNA CTD PMID:15292067 NCBI chr14:3,058,035...3,073,332
Ensembl chr14:3,058,993...3,068,371 		JBrowse link
G Gfi1b growth factor independent 1B transcriptional repressor decreases expression ISO pomalidomide results in decreased expression of GFI1B mRNA CTD PMID:15292067 NCBI chr 3:7,190,721...7,203,444
Ensembl chr 3:7,190,722...7,203,420 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO pomalidomide results in increased expression of ID1 mRNA CTD PMID:15292067 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718 		JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO pomalidomide results in increased expression of ID2 mRNA CTD PMID:15292067 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Ikzf1 IKAROS family zinc finger 1 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein] CTD PMID:29928335 NCBI chr14:91,782,281...91,867,828
Ensembl chr14:91,782,354...91,867,424 		JBrowse link
G Ikzf3 IKAROS family zinc finger 3 multiple interactions ISO [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein] CTD PMID:29928335 NCBI chr10:86,420,757...86,509,454
Ensembl chr10:86,421,582...86,509,454 		JBrowse link
G Il10 interleukin 10 increases secretion ISO pomalidomide results in increased secretion of IL10 protein CTD PMID:15292067 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il13 interleukin 13 decreases secretion ISO pomalidomide results in decreased secretion of IL13 protein CTD PMID:15292067 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO Go 6976 inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]; rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:16241859 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il5 interleukin 5 decreases secretion ISO pomalidomide results in decreased secretion of IL5 protein CTD PMID:15292067 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587 		JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in decreased expression of IRF4 protein; [pomalidomide co-treated with Dexamethasone] results in decreased expression of IRF4 protein CTD PMID:29928335 NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117 		JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases expression ISO pomalidomide results in decreased expression of JUND mRNA CTD PMID:15292067 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707 		JBrowse link
G Klf1 Kruppel like factor 1 decreases expression ISO pomalidomide results in decreased expression of KLF1 mRNA CTD PMID:15292067 NCBI chr19:26,016,289...26,019,557
Ensembl chr19:26,016,382...26,019,553 		JBrowse link
G Lmo2 LIM domain only 2 decreases expression ISO pomalidomide results in decreased expression of LMO2 mRNA CTD PMID:15292067 NCBI chr 3:93,909,156...93,931,888
Ensembl chr 3:93,909,156...93,931,871 		JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589 		JBrowse link
G Nfe2 nuclear factor, erythroid 2 decreases expression ISO pomalidomide results in decreased expression of NFE2 mRNA CTD PMID:15292067 NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092 		JBrowse link
G Prkcq protein kinase C, theta multiple interactions ISO pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein] CTD PMID:16241859 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286 		JBrowse link
G Rab28 RAB28, member RAS oncogene family multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of RAB28 protein CTD PMID:30067223 NCBI chr14:73,888,968...73,963,209
Ensembl chr14:73,889,213...73,963,202 		JBrowse link
G Sall4 spalt-like transcription factor 4 affects binding
multiple interactions		 ISO pomalidomide binds to [SALL4 protein binds to CRBN protein]
pomalidomide results in increased degradation of and results in decreased expression of SALL4 protein		 CTD PMID:30067223 NCBI chr 3:165,520,155...165,538,176
Ensembl chr 3:165,520,392...165,537,940 		JBrowse link
G Spi1 Spi-1 proto-oncogene increases expression
decreases expression		 ISO pomalidomide results in increased expression of SPI1 mRNA
pomalidomide results in decreased expression of SPI1 protein		 CTD PMID:15292067 PMID:16373662 NCBI chr 3:79,918,127...79,937,708
Ensembl chr 3:79,918,969...79,938,301 		JBrowse link
G Wiz WIZ zinc finger multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of WIZ protein CTD PMID:30067223 NCBI chr 7:14,374,358...14,402,647
Ensembl chr 7:14,374,358...14,402,010 		JBrowse link
G Zbtb39 zinc finger and BTB domain containing 39 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZBTB39 protein CTD PMID:30067223 NCBI chr 7:71,036,581...71,044,057
Ensembl chr 7:71,036,565...71,044,045 		JBrowse link
G Zfp653 zinc finger protein 653 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZNF653 protein CTD PMID:30067223 NCBI chr 8:23,066,576...23,085,502
Ensembl chr 8:23,066,576...23,084,879 		JBrowse link
G Zfp91 zinc finger protein 91 multiple interactions ISO pomalidomide results in increased degradation of and results in decreased expression of ZFP91 protein CTD PMID:30067223 NCBI chr 1:229,602,499...229,640,906
Ensembl chr 1:229,602,499...229,639,187 		JBrowse link
thalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases expression ISO Thalidomide results in decreased expression of AADAT mRNA CTD PMID:26217789 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702 		JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 increases response to substance ISO ABCA1 gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
decreases activity		 ISO Thalidomide results in decreased expression of ABCB1 mRNA; Thalidomide results in decreased expression of ABCB1 protein
Thalidomide results in decreased activity of ABCB1 protein		 CTD PMID:15920492 PMID:19840843 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression
increases activity		 EXP Thalidomide results in increased expression of ABCB1B protein
Thalidomide results in increased activity of ABCB1B protein		 CTD PMID:19840843 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO [Thalidomide co-treated with Dexamethasone] results in decreased expression of ACP5 protein CTD PMID:16079895 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 EXP [Thalidomide co-treated with Dimethylnitrosamine] results in decreased expression of ACTA2 protein; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Thalidomide results in decreased expression of ACTA2 protein		 CTD PMID:16604421 PMID:16943688 PMID:17030452 PMID:17174718 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Actn2 actinin alpha 2 decreases expression ISO Thalidomide results in decreased expression of ACTN2 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653 		JBrowse link
G Actr6 actin related protein 6 decreases expression ISO Thalidomide results in decreased expression of ACTR6 mRNA CTD PMID:26217789 NCBI chr 7:30,377,369...30,397,922
Ensembl chr 7:30,377,360...30,397,930 		JBrowse link
G Adssl1 adenylosuccinate synthase like 1 decreases expression ISO Thalidomide results in decreased expression of ADSSL1 mRNA CTD PMID:26217789 NCBI chr 6:137,184,818...137,206,694
Ensembl chr 6:137,184,820...137,206,693 		JBrowse link
G Aff2 AF4/FMR2 family, member 2 decreases expression ISO Thalidomide results in decreased expression of AFF2 mRNA CTD PMID:26217789 NCBI chr  X:153,539,951...154,051,022
Ensembl chr  X:153,539,668...154,051,181 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases activity
increases phosphorylation		 ISO Thalidomide analog results in decreased phosphorylation of AKT1 protein
Thalidomide results in decreased activity of AKT1 protein
Thalidomide analog results in increased phosphorylation of AKT1 protein		 CTD PMID:15067094 PMID:15858615 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Thalidomide results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489 		JBrowse link
G Alpi alkaline phosphatase, intestinal increases expression ISO Thalidomide results in increased expression of ALPI mRNA CTD PMID:26217789 NCBI chr 9:94,197,616...94,201,910
Ensembl chr 9:94,197,618...94,201,084 		JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression ISO Thalidomide results in decreased expression of AMACR mRNA CTD PMID:26217789 NCBI chr 2:60,949,276...60,961,342
Ensembl chr 2:60,949,256...60,961,326 		JBrowse link
G Angpt2 angiopoietin 2 affects expression ISO Thalidomide affects the expression of ANGPT2 mRNA CTD PMID:15939924 NCBI chr16:75,966,480...76,016,147
Ensembl chr16:75,966,352...76,016,195 		JBrowse link
G Ankrd37 ankyrin repeat domain 37 decreases expression ISO Thalidomide results in decreased expression of ANKRD37 mRNA CTD PMID:26217789 NCBI chr16:49,463,016...49,465,905
Ensembl chr16:49,462,889...49,465,888 		JBrowse link
G Anxa2 annexin A2 decreases expression ISO Thalidomide results in decreased expression of ANXA2 mRNA; Thalidomide results in decreased expression of ANXA2 protein CTD PMID:19954599 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594 		JBrowse link
G Apip APAF1 interacting protein decreases expression ISO Thalidomide results in decreased expression of APIP mRNA CTD PMID:26217789 NCBI chr 3:92,969,128...92,998,104
Ensembl chr 3:92,969,141...92,995,483 		JBrowse link
G Apln apelin decreases expression ISO Thalidomide results in decreased expression of APLN mRNA CTD PMID:26217789 NCBI chr  X:134,856,719...134,866,210
Ensembl chr  X:134,856,726...134,866,210 		JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Thalidomide results in increased expression of AQP4 mRNA CTD PMID:26217789 NCBI chr18:6,766,009...6,782,757
Ensembl chr18:6,765,945...6,782,996 		JBrowse link
G Aqp5 aquaporin 5 increases expression ISO Thalidomide results in increased expression of AQP5 mRNA CTD PMID:26217789 NCBI chr 7:141,249,044...141,252,576
Ensembl chr 7:141,249,044...141,252,578 		JBrowse link
G Arhgdia Rho GDP dissociation inhibitor alpha increases expression ISO Thalidomide results in increased expression of ARHGDIA mRNA CTD PMID:26217789 NCBI chr10:109,754,012...109,757,506
Ensembl chr10:109,754,004...109,757,550 		JBrowse link
G Arpc4 actin related protein 2/3 complex, subunit 4 decreases expression ISO Thalidomide results in decreased expression of ARPC4 mRNA CTD PMID:26217789 NCBI chr 4:145,330,457...145,340,985
Ensembl chr 4:145,330,457...145,340,984 		JBrowse link
G Arx aristaless related homeobox increases expression ISO Thalidomide results in increased expression of ARX mRNA CTD PMID:26217789 NCBI chr  X:62,363,757...62,376,139
Ensembl chr  X:62,363,757...62,376,143 		JBrowse link
G Asb12 ankyrin repeat and SOCS box-containing 12 decreases expression ISO Thalidomide results in decreased expression of ASB12 mRNA CTD PMID:26217789 NCBI chr  X:64,714,337...64,800,662
Ensembl chr  X:64,714,335...64,800,435 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Thalidomide analog results in increased expression of ATF3 mRNA CTD PMID:20525221 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Aurka aurora kinase A multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA CTD PMID:18720364 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Thalidomide results in increased expression of BAX mRNA CTD PMID:18291259 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcap29 B-cell receptor-associated protein 29 decreases expression ISO Thalidomide results in decreased expression of BCAP29 mRNA CTD PMID:26217789 NCBI chr 6:50,883,758...50,923,743
Ensembl chr 6:50,883,787...50,923,510 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 mRNA; [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 protein
Thalidomide results in decreased expression of BCL2 protein		 CTD PMID:15867202 PMID:15982930 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Thalidomide results in decreased expression of BCL2L1 protein CTD PMID:15986355 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions ISO Thalidomide inhibits the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein] CTD PMID:16039549 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO Thalidomide promotes the reaction [temozolomide results in increased expression of BECN1 protein] CTD PMID:19567134 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297 		JBrowse link
G Bnipl BCL2 interacting protein like increases expression ISO Thalidomide results in increased expression of BNIPL mRNA CTD PMID:26217789 NCBI chr 2:196,415,736...196,425,727
Ensembl chr 2:196,415,738...196,425,727 		JBrowse link
G Bod1 biorientation of chromosomes in cell division 1 decreases expression ISO Thalidomide results in decreased expression of BOD1 mRNA CTD PMID:26217789 NCBI chr10:16,259,728...16,266,069
Ensembl chr10:16,259,728...16,266,061 		JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Thalidomide results in decreased expression of BST2 mRNA CTD PMID:26217789 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353 		JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of BUB1B mRNA CTD PMID:18720364 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458 		JBrowse link
G C3 complement C3 decreases expression ISO Thalidomide results in decreased expression of C3 protein CTD PMID:2985516 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C decreases expression ISO Thalidomide results in decreased expression of CACNA1C mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 4:150,635,808...151,270,790
Ensembl chr 4:150,641,066...150,829,913 		JBrowse link
G Calb1 calbindin 1 decreases expression ISO Thalidomide results in decreased expression of CALB1 mRNA CTD PMID:24154490 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773 		JBrowse link
G Casp3 caspase 3 decreases activity
increases expression
increases activity		 ISO
EXP		 Thalidomide results in decreased activity of CASP3 protein
Thalidomide results in increased expression of CASP3 mRNA
Thalidomide results in increased activity of CASP3 protein		 CTD PMID:14682394 PMID:15067094 PMID:18291259 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases cleavage
decreases expression		 ISO Thalidomide analog results in increased cleavage of CASP8 protein
Thalidomide results in decreased expression of CASP8 mRNA		 CTD PMID:15858615 PMID:26217789 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 decreases activity ISO Thalidomide results in decreased activity of CASP9 protein CTD PMID:15067094 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Castor1 cytosolic arginine sensor for mTORC1 subunit 1 decreases expression ISO Thalidomide results in decreased expression of CASTOR1 mRNA CTD PMID:26217789 NCBI chr14:84,447,552...84,457,396
Ensembl chr14:84,447,885...84,452,367 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein] CTD PMID:16616857 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cbr1 carbonyl reductase 1 decreases expression ISO Thalidomide results in decreased expression of CBR1 mRNA CTD PMID:26217789 NCBI chr11:33,813,041...33,815,418
Ensembl chr11:33,845,463...33,847,793 		JBrowse link
G Ccdc130 coiled-coil domain containing 130 decreases expression ISO Thalidomide results in decreased expression of CCDC130 mRNA CTD PMID:26217789 NCBI chr19:25,367,552...25,378,993
Ensembl chr19:25,367,543...25,378,974 		JBrowse link
G Ccdc141 coiled-coil domain containing 141 decreases expression ISO Thalidomide results in decreased expression of CCDC141 mRNA CTD PMID:26217789 NCBI chr 3:63,865,240...64,024,208
Ensembl chr 3:63,863,951...64,024,205 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Thalidomide analog results in decreased expression of CCL2 mRNA CTD PMID:20525221 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression EXP Thalidomide results in increased expression of CCL3 mRNA CTD PMID:16549389 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccna2 cyclin A2 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CCNA2 mRNA CTD PMID:18720364 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CCNB1 mRNA CTD PMID:18720364 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Thalidomide analog results in decreased expression of CCND1 mRNA CTD PMID:20525221 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Ccno cyclin O increases expression ISO Thalidomide results in increased expression of CCNO mRNA CTD PMID:26217789 NCBI chr 2:44,857,043...44,860,317
Ensembl chr 2:44,857,213...44,860,315 		JBrowse link
G Cd24 CD24 molecule affects expression ISO Thalidomide affects the expression of CD24A mRNA CTD PMID:26006729 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846 		JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CDC20 mRNA CTD PMID:18720364 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015 		JBrowse link
G Cdc42ep5 CDC42 effector protein 5 decreases expression ISO Thalidomide results in decreased expression of CDC42EP5 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 1:73,717,207...73,719,600
Ensembl chr 1:73,719,005...73,719,529 		JBrowse link
G Cdh10 cadherin 10 decreases expression ISO Thalidomide results in decreased expression of CDH10 mRNA CTD PMID:26217789 NCBI chr 2:69,415,174...69,636,849
Ensembl chr 2:69,415,057...69,637,524 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CDK1 mRNA CTD PMID:18720364 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cenpa centromere protein A multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CENPA mRNA CTD PMID:18720364 NCBI chr 6:27,072,259...27,080,863
Ensembl chr 6:27,072,166...27,080,856 		JBrowse link
G Cenpf centromere protein F multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of CENPF mRNA CTD PMID:18720364 NCBI chr13:108,132,499...108,178,609
Ensembl chr13:108,132,499...108,178,609 		JBrowse link
G Cer1 cerberus 1, DAN family BMP antagonist decreases expression ISO Thalidomide results in decreased expression of CER1 mRNA CTD PMID:26217789 NCBI chr 5:101,003,019...101,006,375
Ensembl chr 5:101,003,023...101,006,375 		JBrowse link
G Cfc1 cripto, FRL-1, cryptic family 1 decreases expression ISO Thalidomide results in decreased expression of CFC1 mRNA CTD PMID:26217789 NCBI chr 9:41,045,352...41,051,979
Ensembl chr 9:41,045,363...41,052,024 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO Thalidomide results in decreased expression of CFLAR protein CTD PMID:15986355 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein] CTD PMID:16604421 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169 		JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Thalidomide results in decreased expression of CHURC1 mRNA CTD PMID:26217789 NCBI chr 6:99,817,439...99,831,574
Ensembl chr 6:99,817,431...99,831,576 		JBrowse link
G Cldn4 claudin 4 increases expression ISO Thalidomide results in increased expression of CLDN4 mRNA CTD PMID:26217789 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005 		JBrowse link
G Cldnd1 claudin domain containing 1 decreases expression ISO Thalidomide results in decreased expression of CLDND1 mRNA CTD PMID:26217789 NCBI chr11:43,986,352...43,992,703
Ensembl chr11:43,986,386...43,992,598 		JBrowse link
G Clec9a C-type lectin domain containing 9A decreases expression ISO Thalidomide results in decreased expression of CLEC9A mRNA CTD PMID:26217789 NCBI chr 4:163,173,593...163,189,532
Ensembl chr 4:163,174,487...163,189,530 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 protein] CTD PMID:26221080 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions EXP Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA] CTD PMID:16604421 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151 		JBrowse link
G Crbn cereblon multiple interactions
affects binding
affects response to substance		 ISO Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
Thalidomide binds to [CRBN protein binds to DDB1 protein]
CRBN gene SNP affects the susceptibility to Thalidomide
Thalidomide binds to [SALL4 protein binds to CRBN protein]; Thalidomide binds to CRBN protein		 CTD PMID:25043012 PMID:25108355 PMID:27751757 PMID:30067223 NCBI chr 4:138,864,910...138,885,786
Ensembl chr 4:138,866,761...138,885,556 		JBrowse link
G Crebrf CREB3 regulatory factor increases expression ISO Thalidomide analog results in increased expression of CREBRF mRNA CTD PMID:20525221 NCBI chr10:16,693,846...16,753,162
Ensembl chr10:16,694,792...16,752,205 		JBrowse link
G Crp C-reactive protein decreases expression ISO Thalidomide results in decreased expression of CRP protein CTD PMID:11339241 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713 		JBrowse link
G Csf2 colony stimulating factor 2 decreases activity ISO Thalidomide results in decreased activity of CSF2 protein CTD PMID:17557286 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070 		JBrowse link
G Csf3 colony stimulating factor 3 decreases activity ISO Thalidomide results in decreased activity of CSF3 protein CTD PMID:17557286 NCBI chr10:86,616,785...86,619,160
Ensembl chr10:86,616,785...86,619,157 		JBrowse link
G Csgalnact2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 decreases expression ISO Thalidomide results in decreased expression of CSGALNACT2 mRNA CTD PMID:26217789 NCBI chr 4:150,148,626...150,185,062
Ensembl chr 4:150,153,844...150,185,044 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression ISO Thalidomide results in increased expression of CXCL10 CTD PMID:17089043 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO Thalidomide results in decreased expression of CXCR1 protein CTD PMID:16344495 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO Thalidomide results in decreased expression of CXCR2 protein CTD PMID:16344495 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO Thalidomide results in increased expression of CYCS protein CTD PMID:15982930 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Thalidomide results in increased expression of CYP2B6 mRNA CTD PMID:24460184 PMID:28496040 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases hydroxylation
multiple interactions
increases oxidation		 ISO CYP2C19 protein results in increased hydroxylation of Thalidomide
[CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5'-hydroxythalidomide; [CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5'-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5-hydroxythalidomide		 CTD PMID:20443640 PMID:24350712 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
increases hydroxylation
multiple interactions
increases metabolic processing		 ISO Thalidomide results in increased expression of CYP3A4 mRNA; Thalidomide results in increased expression of CYP3A4 protein
CYP3A4 protein results in increased hydroxylation of Thalidomide
[CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide
CYP3A4 protein results in increased metabolism of Thalidomide		 CTD PMID:20443640 PMID:24460184 PMID:28496040 PMID:28745489 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
increases metabolic processing
increases expression
increases hydroxylation		 ISO [CYP3A5 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide
CYP3A5 protein results in increased metabolism of Thalidomide
Thalidomide results in increased expression of CYP3A5 mRNA		 CTD PMID:20443640 PMID:28496040 PMID:28745489 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Cyth3 cytohesin 3 decreases expression ISO Thalidomide results in decreased expression of CYTH3 mRNA CTD PMID:26217789 NCBI chr12:12,877,559...12,907,771
Ensembl chr12:12,877,559...12,945,192 		JBrowse link
G Daam2 dishevelled associated activator of morphogenesis 2 decreases expression ISO Thalidomide results in decreased expression of DAAM2 mRNA CTD PMID:26217789 NCBI chr 9:13,444,883...13,493,154
Ensembl chr 9:13,446,896...13,490,669 		JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 decreases expression ISO Thalidomide results in decreased expression of DBT mRNA CTD PMID:26217789 NCBI chr 2:219,563,783...219,592,651
Ensembl chr 2:219,563,783...219,592,650 		JBrowse link
G Ddb1 damage-specific DNA binding protein 1 affects binding ISO Thalidomide binds to [CRBN protein binds to DDB1 protein] CTD PMID:25108355 NCBI chr 1:226,657,561...226,683,356
Ensembl chr 1:226,657,561...226,683,347 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Thalidomide analog results in increased expression of DDIT3 mRNA CTD PMID:20525221 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Defa10 defensin alpha 10 increases expression ISO Thalidomide results in increased expression of DEFA3 mRNA CTD PMID:26217789 NCBI chr16:75,498,236...75,499,012
Ensembl chr16:75,498,236...75,499,012 		JBrowse link
G Defb15 defensin beta 15 increases expression ISO Thalidomide results in increased expression of DEFB15 mRNA CTD PMID:26217789 NCBI chr16:75,105,290...75,107,931
Ensembl chr16:75,105,290...75,107,931
Ensembl chr16:75,105,290...75,107,931 		JBrowse link
G Des desmin multiple interactions EXP Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of DES protein] CTD PMID:17030452 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294 		JBrowse link
G Dexi Dexi homolog increases expression ISO Thalidomide results in increased expression of DEXI mRNA CTD PMID:26217789 NCBI chr10:5,199,226...5,211,913
Ensembl chr10:5,199,226...5,211,913 		JBrowse link
G Dlgap5 DLG associated protein 5 decreases expression ISO Thalidomide results in decreased expression of DLGAP5 mRNA CTD PMID:26217789 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 decreases expression ISO Thalidomide results in decreased expression of DLK1 mRNA CTD PMID:26217789 NCBI chr 6:133,576,513...133,583,751
Ensembl chr 6:133,552,821...133,583,751 		JBrowse link
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 increases expression ISO Thalidomide analog results in increased expression of DNAJB1 mRNA CTD PMID:20525221 NCBI chr19:24,747,178...24,750,919
Ensembl chr19:24,747,178...24,750,919 		JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression ISO Thalidomide analog results in increased expression of DNAJB4 mRNA CTD PMID:20525221 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242 		JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression ISO Thalidomide analog results in increased expression of DNAJB9 mRNA CTD PMID:20525221 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151 		JBrowse link
G Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 decreases expression ISO Thalidomide results in decreased expression of DNAJC19 mRNA CTD PMID:26217789 NCBI chr 2:120,503,093...120,531,782
Ensembl chr 2:120,504,130...120,531,782 		JBrowse link
G Dus4l dihydrouridine synthase 4-like decreases expression ISO Thalidomide results in decreased expression of DUS4L mRNA CTD PMID:26217789 NCBI chr 6:50,925,987...50,943,546
Ensembl chr 6:50,928,397...50,943,488 		JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression ISO Thalidomide analog results in increased expression of DUSP1 mRNA CTD PMID:20525221 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418 		JBrowse link
G Dusp10 dual specificity phosphatase 10 increases expression ISO Thalidomide analog results in increased expression of DUSP10 mRNA CTD PMID:20525221 NCBI chr13:104,284,660...104,321,455
Ensembl chr13:104,284,660...104,321,455 		JBrowse link
G Dusp8 dual specificity phosphatase 8 increases expression ISO Thalidomide analog results in increased expression of DUSP8 mRNA CTD PMID:20525221 NCBI chr 1:215,030,429...215,043,111
Ensembl chr 1:215,030,429...215,033,460 		JBrowse link
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO Thalidomide results in decreased expression of EEF1E1 mRNA CTD PMID:26217789 NCBI chr17:26,785,017...26,795,723
Ensembl chr17:26,785,029...26,797,161 		JBrowse link
G Efcab2 EF-hand calcium binding domain 2 decreases expression ISO Thalidomide results in decreased expression of EFCAB2 mRNA CTD PMID:26217789 NCBI chr13:96,303,578...96,414,404
Ensembl chr13:96,303,703...96,414,404 		JBrowse link
G Eif1b eukaryotic translation initiation factor 1B decreases expression ISO Thalidomide results in decreased expression of EIF1B mRNA CTD PMID:26217789 NCBI chr 8:129,158,112...129,160,726
Ensembl chr 8:129,158,103...129,160,757 		JBrowse link
G Eif4e eukaryotic translation initiation factor 4E decreases expression EXP Thalidomide results in decreased expression of EIF4E protein CTD PMID:18291259 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631 		JBrowse link
G Elane elastase, neutrophil expressed multiple interactions ISO Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of ELANE protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein] CTD PMID:11302825 NCBI chr 7:12,638,320...12,640,168
Ensembl chr 7:12,638,322...12,640,232 		JBrowse link
G Emc8 ER membrane protein complex subunit 8 decreases expression ISO Thalidomide results in decreased expression of EMC8 mRNA CTD PMID:26217789 NCBI chr19:54,235,949...54,245,810
Ensembl chr19:54,235,936...54,245,855 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO [ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite CTD PMID:28745489 NCBI chr10:86,367,596...86,391,728
Ensembl chr10:86,367,596...86,391,728 		JBrowse link
G Esd esterase D decreases expression ISO Thalidomide results in decreased expression of ESD mRNA CTD PMID:26217789 NCBI chr15:56,756,848...56,776,348
Ensembl chr15:56,756,661...56,776,348 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Thalidomide results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142 		JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO Thalidomide results in decreased expression of F2R mRNA; Thalidomide results in decreased expression of F2R protein CTD PMID:15618473 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340 		JBrowse link
G Fabp5 fatty acid binding protein 5 decreases expression ISO Thalidomide results in decreased expression of FABP5 mRNA CTD PMID:26217789 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378 		JBrowse link
G Fabp7 fatty acid binding protein 7 affects expression ISO Thalidomide affects the expression of FABP7 mRNA CTD PMID:26217789 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349 		JBrowse link
G Fam174b family with sequence similarity 174, member B decreases expression ISO Thalidomide results in decreased expression of FAM174B mRNA CTD PMID:26217789 NCBI chr 1:135,081,596...135,180,266
Ensembl chr 1:135,083,974...135,162,685 		JBrowse link
G Fas Fas cell surface death receptor decreases expression
increases expression		 ISO
EXP		 Thalidomide results in decreased expression of FAS protein
Thalidomide results in increased expression of FAS mRNA		 CTD PMID:16531263 PMID:18291259 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand multiple interactions
decreases expression		 ISO Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]
Thalidomide results in decreased expression of FASLG protein		 CTD PMID:16510725 PMID:16531263 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fen1 flap structure-specific endonuclease 1 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of FEN1 mRNA CTD PMID:18720364 NCBI chr 1:226,251,516...226,256,160
Ensembl chr 1:226,251,518...226,255,886 		JBrowse link
G Fgd3 FYVE, RhoGEF and PH domain containing 3 increases expression ISO Thalidomide results in increased expression of FGD3 mRNA CTD PMID:26217789 NCBI chr17:15,737,962...15,800,403
Ensembl chr17:15,749,978...15,800,401 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases response to substance
decreases expression
multiple interactions
decreases activity
affects secretion
affects expression		 ISO
EXP		 FGF2 protein results in increased susceptibility to Thalidomide
Thalidomide results in decreased expression of FGF2 protein
[temozolomide co-treated with Thalidomide] results in decreased expression of FGF2 protein
Thalidomide results in decreased activity of FGF2 protein
Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide affects the secretion of FGF2 protein
Thalidomide affects the expression of FGF2 mRNA; Thalidomide affects the expression of FGF2 protein		 CTD PMID:11555579 PMID:12644816 PMID:14558594 PMID:15863203 PMID:15939924 PMID:16327979 PMID:17557286 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Thalidomide results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO Thalidomide affects the expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Thalidomide results in decreased expression of FGFR2 mRNA; Thalidomide results in decreased expression of FGFR2 protein CTD PMID:30834740 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928 		JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 affects expression ISO Thalidomide affects the expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Thalidomide analog results in increased expression of FOS mRNA CTD PMID:20525221 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Thalidomide analog results in increased expression of FOSB mRNA CTD PMID:20525221 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710 		JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Thalidomide results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081 		JBrowse link
G Foxred1 FAD-dependent oxidoreductase domain containing 1 decreases expression ISO Thalidomide results in decreased expression of FOXRED1 mRNA CTD PMID:26217789 NCBI chr 8:36,401,317...36,410,589
Ensembl chr 8:36,403,493...36,410,612 		JBrowse link
G Fzd8 frizzled class receptor 8 decreases expression ISO Thalidomide results in decreased expression of FZD8 mRNA CTD PMID:24154490 NCBI chr17:62,259,910...62,267,239
Ensembl chr17:62,262,129...62,265,113 		JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta multiple interactions ISO Thalidomide inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA] CTD PMID:15797874 NCBI chr 7:11,646,283...11,648,338
Ensembl chr 7:11,646,269...11,648,322 		JBrowse link
G Galm galactose mutarotase decreases expression ISO Thalidomide results in decreased expression of GALM mRNA CTD PMID:26217789 NCBI chr 6:2,808,988...2,860,742
Ensembl chr 6:2,808,841...2,860,744 		JBrowse link
G Gata3 GATA binding protein 3 increases expression EXP Thalidomide results in increased expression of GATA3 protein CTD PMID:19428696 NCBI chr17:72,419,752...72,452,043
Ensembl chr17:72,429,618...72,450,681 		JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) decreases expression ISO Thalidomide results in decreased expression of GCNT2 mRNA CTD PMID:26217789 NCBI chr17:21,634,546...21,677,477
Ensembl chr17:21,634,551...21,739,408 		JBrowse link
G Gemin2 gem (nuclear organelle) associated protein 2 decreases expression ISO Thalidomide results in decreased expression of GEMIN2 mRNA CTD PMID:26217789 NCBI chr 6:80,108,751...80,122,382
Ensembl chr 6:80,108,655...80,122,365 		JBrowse link
G Gfra2 GDNF family receptor alpha 2 decreases expression ISO Thalidomide results in decreased expression of GFRA2 mRNA CTD PMID:26217789 NCBI chr15:52,557,004...52,648,984
Ensembl chr15:52,557,607...52,648,972 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Thalidomide results in increased expression of GOT1 mRNA CTD PMID:26217789 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762 		JBrowse link
G Gp2 glycoprotein 2 increases expression ISO Thalidomide results in increased expression of GP2 mRNA CTD PMID:26217789 NCBI chr 1:189,166,735...189,182,306
Ensembl chr 1:189,166,399...189,182,306 		JBrowse link
G Gpatch4 G patch domain containing 4 decreases expression ISO Thalidomide results in decreased expression of GPATCH4 mRNA CTD PMID:26217789 NCBI chr 2:187,404,731...187,424,047
Ensembl chr 2:187,415,262...187,424,045 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GPX1 protein] CTD PMID:17030452 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gpx8 glutathione peroxidase 8 decreases expression ISO Thalidomide results in decreased expression of GPX8 mRNA CTD PMID:26217789 NCBI chr 2:44,903,337...44,907,046
Ensembl chr 2:44,903,337...44,907,030 		JBrowse link
G Gtf2e1 general transcription factor IIE subunit 1 decreases expression ISO Thalidomide results in decreased expression of GTF2E1 mRNA CTD PMID:26217789 NCBI chr11:66,078,786...66,111,394
Ensembl chr11:66,078,820...66,110,848 		JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO Thalidomide results in decreased expression of GULP1 mRNA CTD PMID:26217789 NCBI chr 9:51,263,484...51,538,066
Ensembl chr 9:51,263,622...51,538,072 		JBrowse link
G H2bc12 H2B clustered histone 12 decreases expression ISO Thalidomide results in decreased expression of H2BC12 mRNA CTD PMID:26217789 NCBI chr17:44,527,421...44,527,801
Ensembl chr17:44,527,421...44,527,801 		JBrowse link
G H2bu1 H2B.U histone 1 decreases expression ISO Thalidomide results in decreased expression of H2BU2 mRNA CTD PMID:26217789 NCBI chr10:45,296,638...45,297,385
Ensembl chr10:45,296,638...45,297,385 		JBrowse link
G H3c1 H3 clustered histone 1 decreases expression ISO Thalidomide results in decreased expression of H3C1 mRNA CTD PMID:26217789 NCBI chr17:43,616,206...43,616,735
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131
Ensembl chr17:44,839,721...44,840,131 		JBrowse link
G H3f3c H3 histone family member 3C decreases expression ISO Thalidomide results in decreased expression of H3C15 mRNA CTD PMID:26217789 NCBI chr 7:94,777,659...94,778,656
Ensembl chr 7:94,777,702...94,778,696 		JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 decreases expression ISO Thalidomide results in decreased expression of HCN1 mRNA CTD PMID:26217789 NCBI chr 2:50,099,576...50,499,799
Ensembl chr 2:50,099,576...50,499,799 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Thalidomide analog results in increased expression of HERPUD1 mRNA CTD PMID:20525221 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254 		JBrowse link
G Hgf hepatocyte growth factor affects expression
affects secretion
decreases activity		 ISO Thalidomide affects the expression of HGF mRNA; Thalidomide affects the expression of HGF protein
Thalidomide affects the secretion of HGF protein
Thalidomide results in decreased activity of HGF protein		 CTD PMID:15939924 PMID:17557286 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362 		JBrowse link
G Hirip3 HIRA interacting protein 3 decreases expression ISO Thalidomide results in decreased expression of HIRIP3 mRNA CTD PMID:26217789 NCBI chr 1:198,298,138...198,301,164
Ensembl chr 1:198,298,138...198,301,161 		JBrowse link
G Hist1h2af histone cluster 1 H2A family member F decreases expression ISO Thalidomide results in decreased expression of H2AC15 mRNA CTD PMID:26217789 NCBI chr17:43,627,237...43,627,629
Ensembl chr17:43,627,237...43,627,629 		JBrowse link
G Hist1h2bc histone cluster 1, H2bc decreases expression ISO Thalidomide results in decreased expression of H2BC4 mRNA CTD PMID:26217789 NCBI chr17:44,736,184...44,738,393
Ensembl chr17:44,737,950...44,738,330
Ensembl chr17:44,737,950...44,738,330 		JBrowse link
G Hist2h4 histone cluster 2, H4 decreases expression ISO Thalidomide results in decreased expression of H4C11 mRNA CTD PMID:26217789 NCBI chr 2:198,411,955...198,412,350
Ensembl chr 2:198,411,955...198,412,350 		JBrowse link
G Hmgn5 high mobility group nucleosome binding domain 5 decreases expression ISO Thalidomide results in decreased expression of HMGN5 mRNA CTD PMID:26217789 NCBI chr  X:80,134,557...80,142,902
Ensembl chr  X:80,134,557...80,142,902 		JBrowse link
G Hoxb7 homeo box B7 increases expression ISO Thalidomide results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr10:84,135,224...84,138,642
Ensembl chr10:84,135,116...84,138,637 		JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Thalidomide results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression ISO Thalidomide results in decreased expression of HSD11B2 mRNA CTD PMID:26217789 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307 		JBrowse link
G Hsf1 heat shock transcription factor 1 decreases expression ISO Thalidomide results in decreased expression of HSF1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 7:117,538,523...117,565,478
Ensembl chr 7:117,538,523...117,565,478 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO Thalidomide results in decreased expression of HSPB1 mRNA CTD PMID:26217789 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049 		JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression ISO Thalidomide analog results in increased expression of HSPH1 mRNA CTD PMID:20525221 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases response to substance
decreases expression		 ISO
EXP		 ICAM1 gene SNP results in increased susceptibility to Thalidomide
Thalidomide results in decreased expression of ICAM1 mRNA; Thalidomide results in decreased expression of ICAM1 protein		 CTD PMID:17174718 PMID:21245421 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Idnk Idnk, gluconokinase decreases expression ISO Thalidomide results in decreased expression of IDNK mRNA CTD PMID:26217789 NCBI chr17:6,885,323...6,892,603
Ensembl chr17:6,885,221...6,892,497 		JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
increases expression
affects expression		 ISO
EXP		 [Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
Thalidomide results in decreased expression of IFNG protein
Thalidomide inhibits the reaction [irinotecan results in increased expression of IFNG protein]; Thalidomide promotes the reaction [irinotecan results in increased expression of IFNG protein]
Thalidomide results in increased expression of IFNG; Thalidomide results in increased expression of IFNG protein
Thalidomide affects the expression of IFNG mRNA		 CTD PMID:15588918 PMID:16078585 PMID:16454849 PMID:16514283 PMID:16815871 PMID:17089043 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Ift27 intraflagellar transport 27 decreases expression ISO Thalidomide results in decreased expression of IFT27 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 7:119,393,384...119,409,710
Ensembl chr 7:119,393,384...119,409,710 		JBrowse link
G Ift74 intraflagellar transport 74 decreases expression ISO Thalidomide results in decreased expression of IFT74 mRNA CTD PMID:26217789 NCBI chr 5:113,579,065...113,682,485
Ensembl chr 5:113,592,919...113,682,484 		JBrowse link
G Igf1 insulin-like growth factor 1 affects expression ISO Thalidomide affects the expression of IGF1 mRNA CTD PMID:15939924 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609 		JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 affects expression
decreases expression		 ISO Thalidomide affects the expression of IGFBP3 mRNA
Thalidomide results in decreased expression of IGFBP3 mRNA		 CTD PMID:15939924 PMID:26217789 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374 		JBrowse link
G Il10 interleukin 10 affects expression
decreases expression		 ISO Thalidomide affects the expression of IL10 mRNA
Thalidomide results in decreased expression of IL10 protein		 CTD PMID:16454849 PMID:16514283 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:11788559 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein]
Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]		 CTD PMID:11788559 PMID:16510725 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085 		JBrowse link
G Il18 interleukin 18 increases expression ISO Thalidomide results in increased expression of IL18 CTD PMID:17089043 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299 		JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions		 ISO
EXP		 Thalidomide results in decreased expression of IL1B protein
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]
Thalidomide inhibits the reaction [irinotecan results in increased expression of IL1B protein]; Thalidomide promotes the reaction [irinotecan results in increased expression of IL1B protein]		 CTD PMID:15863203 PMID:16815871 PMID:23510834 PMID:25478868 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO Thalidomide results in decreased expression of IL1R1 mRNA CTD PMID:15618473 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670 		JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA] CTD PMID:16510725 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614 		JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression		 ISO
EXP		 [Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
Thalidomide inhibits the reaction [irinotecan results in decreased expression of IL2 protein]; Thalidomide promotes the reaction [irinotecan results in decreased expression of IL2 protein]
Thalidomide results in decreased expression of IL2 protein		 CTD PMID:15588918 PMID:16815871 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854 		JBrowse link
G Il4 interleukin 4 increases expression EXP Thalidomide results in increased expression of IL4 protein CTD PMID:16078585 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531 		JBrowse link
G Il6 interleukin 6 decreases secretion
multiple interactions
decreases activity		 ISO
EXP		 Thalidomide analog results in decreased secretion of IL6 protein
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]
Thalidomide inhibits the reaction [irinotecan results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]
Thalidomide results in decreased activity of IL6 protein		 CTD PMID:15858615 PMID:16815871 PMID:17557286 PMID:23510834 PMID:25478868 PMID:26221080 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Il6st interleukin 6 signal transducer decreases expression ISO Thalidomide results in decreased expression of IL6ST mRNA CTD PMID:15618473 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944 		JBrowse link
G Ing3 inhibitor of growth family, member 3 increases expression ISO Thalidomide analog results in increased expression of ING3 mRNA CTD PMID:20525221 NCBI chr 4:49,017,235...49,044,450
Ensembl chr 4:49,017,311...49,042,990 		JBrowse link
G Ipp intracisternal A particle-promoted polypeptide decreases expression ISO Thalidomide results in decreased expression of IPP mRNA CTD PMID:26217789 NCBI chr 5:135,351,767...135,390,363
Ensembl chr 5:135,351,816...135,388,083 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression ISO Thalidomide analog results in increased expression of JUN mRNA CTD PMID:20525221 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Kif2c kinesin family member 2C multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of KIF2C mRNA CTD PMID:18720364 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210 		JBrowse link
G Klhl4 kelch-like family member 4 decreases expression ISO Thalidomide results in decreased expression of KLHL4 mRNA CTD PMID:26217789 NCBI chr  X:86,125,929...86,229,565
Ensembl chr  X:86,126,157...86,229,563 		JBrowse link
G Klk1 kallikrein 1 decreases expression ISO Thalidomide results in decreased expression of KLK1 mRNA CTD PMID:26217789 NCBI chr 1:100,131,562...100,135,556
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329
Ensembl chr 1:100,059,967...100,203,329 		JBrowse link
G Krtap1-1 keratin associated protein 1-1 increases expression ISO Thalidomide results in increased expression of KRTAP1-4 mRNA CTD PMID:26217789 NCBI chr10:87,502,950...87,503,578
Ensembl chr10:87,502,817...87,503,591 		JBrowse link
G Lats2 large tumor suppressor kinase 2 increases expression ISO Thalidomide analog results in increased expression of LATS2 mRNA CTD PMID:20525221 NCBI chr15:37,943,609...37,995,175
Ensembl chr15:37,943,609...37,983,882 		JBrowse link
G LOC100364500 RT1 class I, locus CE11-like increases expression ISO Thalidomide results in increased expression of H2-Q1 mRNA CTD PMID:26217789 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120 		JBrowse link
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like increases expression ISO Thalidomide results in increased expression of USP17LE mRNA CTD PMID:26217789 NCBI chr 1:169,720,247...169,721,788
Ensembl chr 1:169,720,253...169,721,758 		JBrowse link
G LOC100910669 paired immunoglobulin-like type 2 receptor alpha-like decreases expression ISO Thalidomide results in decreased expression of PILRA mRNA CTD PMID:26217789 NCBI chr12:21,678,550...21,689,821
Ensembl chr12:21,678,580...21,690,678 		JBrowse link
G LOC100910887 olfactory receptor 6C4-like decreases expression ISO Thalidomide results in decreased expression of OLFR820 mRNA CTD PMID:26217789 NCBI chr13:9,479,995...9,480,933
Ensembl chr13:9,479,995...9,480,933 		JBrowse link
G LOC100912290 histone H4-like decreases expression ISO Thalidomide results in decreased expression of H4C4 mRNA CTD PMID:26217789 NCBI chr 4:170,092,457...170,117,607 JBrowse link
G LOC100912489 histone H4-like decreases expression ISO Thalidomide results in decreased expression of H4C3 mRNA CTD PMID:26217789 NCBI chr 4:170,144,871...170,145,311
Ensembl chr 4:170,144,951...170,145,262 		JBrowse link
G LOC102553760 zinc finger protein 59-like decreases expression ISO Thalidomide results in decreased expression of ZFP780B mRNA CTD PMID:26217789 NCBI chr 1:84,719,744...84,739,532 JBrowse link
G LOC103689988 2'-5'-oligoadenylate synthase 1A-like decreases expression ISO Thalidomide results in decreased expression of OAS1G mRNA CTD PMID:26217789 NCBI chr12:42,367,110...42,376,531
Ensembl chr12:42,367,535...42,376,426 		JBrowse link
G LOC103690022 protein N-terminal asparagine amidohydrolase decreases expression ISO Thalidomide results in decreased expression of NTAN1 mRNA CTD PMID:26217789 NCBI chr10:3,218,408...3,235,229
Ensembl chr10:3,218,466...3,235,229 		JBrowse link
G LOC501406 similar to regulator of sex-limitation candidate 1 decreases expression ISO Thalidomide results in decreased expression of ZFP273 mRNA CTD PMID:26217789 NCBI chr 1:38,581,867...38,597,702
Ensembl chr 1:38,582,629...38,586,563 		JBrowse link
G LOC687082 similar to olfactory receptor 508 increases expression ISO Thalidomide results in increased expression of OLFR508 mRNA CTD PMID:26217789 NCBI chr 1:172,860,666...172,861,690
Ensembl chr 1:172,860,797...172,861,597 		JBrowse link
G Lrr1 leucine rich repeat protein 1 decreases expression ISO Thalidomide results in decreased expression of LRR1 mRNA CTD PMID:26217789 NCBI chr 6:91,463,205...91,472,308
Ensembl chr 6:91,463,308...91,472,308 		JBrowse link
G Ltf lactotransferrin multiple interactions ISO Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of LTF protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein] CTD PMID:11302825 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261 		JBrowse link
G Ly96 lymphocyte antigen 96 decreases expression ISO Thalidomide results in decreased expression of LY96 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 5:1,972,212...1,989,448 JBrowse link
G Lyrm2 LYR motif containing 2 decreases expression ISO Thalidomide results in decreased expression of LYRM2 mRNA CTD PMID:26217789 NCBI chr 5:48,047,913...48,050,191
Ensembl chr 5:48,047,913...48,050,187 		JBrowse link
G Lyrm4 LYR motif containing 4 decreases expression ISO Thalidomide results in decreased expression of LYRM4 mRNA CTD PMID:26217789 NCBI chr17:29,439,042...29,552,773
Ensembl chr17:29,438,980...29,552,790 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO Thalidomide promotes the reaction [temozolomide results in increased expression of MAP1LC3B protein] CTD PMID:19567134 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Thalidomide analog results in increased phosphorylation of MAPK1 protein CTD PMID:15858615 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases phosphorylation ISO Thalidomide analog results in increased phosphorylation of MAPK14 protein CTD PMID:15858615 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Thalidomide analog results in increased phosphorylation of MAPK3 protein CTD PMID:15858615 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO Thalidomide analog results in decreased expression of MCL1 protein CTD PMID:15858615 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mcm5 minichromosome maintenance complex component 5 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of MCM5 mRNA CTD PMID:18720364 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278 		JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589 		JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Thalidomide results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491 		JBrowse link
G Mesp2 mesoderm posterior bHLH transcription factor 2 decreases expression ISO Thalidomide results in decreased expression of MESP2 mRNA CTD PMID:31711903 NCBI chr 1:141,550,633...141,553,239
Ensembl chr 1:141,550,633...141,553,230 		JBrowse link
G Mettl5 methyltransferase like 5 decreases expression ISO Thalidomide results in decreased expression of METTL5 mRNA CTD PMID:26217789 NCBI chr 3:56,101,597...56,113,823
Ensembl chr 3:56,101,580...56,113,857 		JBrowse link
G Mir301b microRNA 301b increases expression ISO Thalidomide results in increased expression of MIR301B mRNA CTD PMID:26217789 NCBI chr11:88,129,426...88,129,503
Ensembl chr11:88,129,426...88,129,503 		JBrowse link
G Mir30e microRNA 30e decreases expression ISO Thalidomide results in decreased expression of MIR30E mRNA CTD PMID:26217789 NCBI chr 5:139,702,872...139,702,963
Ensembl chr 5:139,702,872...139,702,963 		JBrowse link
G Mir449c microRNA 449c increases expression ISO Thalidomide results in increased expression of MIR449C mRNA CTD PMID:26217789 NCBI chr 2:44,896,066...44,896,164
Ensembl chr 2:44,896,066...44,896,164 		JBrowse link
G Mixl1 Mix paired-like homeobox 1 decreases expression ISO Thalidomide results in decreased expression of MIXL1 mRNA CTD PMID:26217789 NCBI chr13:97,278,258...97,282,299
Ensembl chr13:98,973,041...98,975,426
Ensembl chr13:98,973,041...98,975,426 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of MKI67 mRNA CTD PMID:18720364 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mlf2 myeloid leukemia factor 2 decreases expression ISO Thalidomide results in decreased expression of MLF2 mRNA CTD PMID:26217789 NCBI chr 4:157,452,578...157,457,254
Ensembl chr 4:157,452,607...157,457,249 		JBrowse link
G Mme membrane metallo-endopeptidase decreases expression ISO Thalidomide results in decreased expression of MME mRNA CTD PMID:26217789 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide results in decreased expression of MMP2 protein		 CTD PMID:14558594 PMID:15863203 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Thalidomide results in decreased expression of MMP9 protein CTD PMID:15863203 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Moxd1 monooxygenase, DBH-like 1 decreases expression ISO Thalidomide results in decreased expression of MOXD1 mRNA CTD PMID:26217789 NCBI chr 1:22,124,498...22,206,565
Ensembl chr 1:22,124,495...22,206,505 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Thalidomide inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:15138204 PMID:25478868 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260 		JBrowse link
G Mpp1 membrane palmitoylated protein 1 decreases expression ISO Thalidomide results in decreased expression of MPP1 mRNA CTD PMID:26217789 NCBI chr 1:148,450,213...148,458,945 JBrowse link
G Mrpl32 mitochondrial ribosomal protein L32 decreases expression ISO Thalidomide results in decreased expression of MRPL32 mRNA CTD PMID:26217789 NCBI chr17:53,102,534...53,105,400
Ensembl chr17:53,102,534...53,105,400 		JBrowse link
G Mrpl34 mitochondrial ribosomal protein L34 decreases expression ISO Thalidomide results in decreased expression of MRPL34 mRNA CTD PMID:26217789 NCBI chr16:19,874,034...19,874,769
Ensembl chr16:19,874,034...19,874,768 		JBrowse link
G Mrpl47 mitochondrial ribosomal protein L47 decreases expression ISO Thalidomide results in decreased expression of MRPL47 mRNA CTD PMID:26217789 NCBI chr 2:119,128,311...119,139,451
Ensembl chr 2:119,128,309...119,139,451 		JBrowse link
G Mrpl52 mitochondrial ribosomal protein L52 decreases expression ISO Thalidomide results in decreased expression of MRPL52 mRNA CTD PMID:26217789 NCBI chr15:33,069,479...33,072,777
Ensembl chr15:33,069,382...33,072,777 		JBrowse link
G Mrps21 mitochondrial ribosomal protein S21 decreases expression ISO Thalidomide results in decreased expression of MRPS21 mRNA CTD PMID:26217789 NCBI chr 2:197,974,758...197,982,385
Ensembl chr 2:197,974,761...197,982,385 		JBrowse link
G Mtfr2 mitochondrial fission regulator 2 decreases expression ISO Thalidomide results in decreased expression of MTFR2 mRNA CTD PMID:26217789 NCBI chr 1:15,834,779...15,850,424
Ensembl chr 1:15,782,477...15,860,624 		JBrowse link
G Myb MYB proto-oncogene, transcription factor multiple interactions
decreases phosphorylation
decreases activity		 ISO CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein]
Thalidomide results in decreased phosphorylation of MYB protein		 CTD PMID:16616857 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817 		JBrowse link
G Mybpc3 myosin binding protein C3 decreases expression ISO Thalidomide results in decreased expression of MYBPC3 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 3:79,940,509...79,958,731
Ensembl chr 3:79,940,561...79,958,730 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor decreases expression ISO Thalidomide results in decreased expression of MYD88 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Myh6 myosin heavy chain 6 affects expression ISO Thalidomide affects the expression of MYH6 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699 		JBrowse link
G Myl3 myosin light chain 3 affects expression
decreases expression		 ISO Thalidomide affects the expression of MYL3 mRNA
Thalidomide results in decreased expression of MYL3 mRNA		 CTD PMID:26006729 PMID:26217789 NCBI chr 8:119,030,852...119,036,996
Ensembl chr 8:119,030,875...119,036,996 		JBrowse link
G Myl7 myosin light chain 7 decreases expression ISO Thalidomide results in decreased expression of MYL7 mRNA CTD PMID:26217789 NCBI chr14:86,144,770...86,147,075
Ensembl chr14:86,143,862...86,147,553 		JBrowse link
G Mylk myosin light chain kinase increases expression ISO Thalidomide results in increased expression of MYLK mRNA CTD PMID:26217789 NCBI chr11:69,013,060...69,260,039
Ensembl chr11:69,013,050...69,223,158 		JBrowse link
G Myom1 myomesin 1 decreases expression ISO Thalidomide results in decreased expression of MYOM1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 9:119,353,840...119,469,196
Ensembl chr 9:119,353,840...119,468,715 		JBrowse link
G Naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit decreases expression ISO Thalidomide results in decreased expression of NAA20 mRNA CTD PMID:26217789 NCBI chr 3:140,106,723...140,125,047
Ensembl chr 3:140,106,766...140,125,220 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO Thalidomide results in decreased expression of NANOG mRNA CTD PMID:26217789 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268 		JBrowse link
G Naxe NAD(P)HX epimerase decreases expression ISO Thalidomide results in decreased expression of NAXE mRNA CTD PMID:26217789 NCBI chr 2:187,424,319...187,426,410
Ensembl chr 2:187,424,327...187,426,375 		JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Thalidomide results in decreased expression of NDUFB8 mRNA CTD PMID:26217789 NCBI chr 1:264,298,671...264,303,712
Ensembl chr 1:264,298,669...264,303,762 		JBrowse link
G Nebl nebulette decreases expression ISO Thalidomide results in decreased expression of NEBL mRNA CTD PMID:26217789 NCBI chr17:84,141,014...84,247,038
Ensembl chr17:84,140,489...84,488,601 		JBrowse link
G Neurod4 neuronal differentiation 4 increases expression ISO Thalidomide results in increased expression of NEUROD4 mRNA CTD PMID:26217789 NCBI chr 7:9,699,964...9,712,067
Ensembl chr 7:9,699,961...9,711,928 		JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Thalidomide results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 protein] CTD PMID:25579023 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression		 ISO
EXP		 [resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]
Thalidomide results in decreased expression of NFKB1 protein		 CTD PMID:16333628 PMID:17164350 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases expression		 ISO
EXP		 Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Thalidomide results in increased expression of NFKBIA protein
Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]		 CTD PMID:15687330 PMID:16288038 PMID:16604421 PMID:16943688 PMID:17174718 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nhlh1 nescient helix loop helix 1 increases expression ISO Thalidomide results in increased expression of NHLH1 mRNA CTD PMID:26217789 NCBI chr13:90,437,956...90,443,157
Ensembl chr13:90,437,956...90,443,157 		JBrowse link
G NMS neuromedin S increases expression ISO Thalidomide results in increased expression of NMS mRNA CTD PMID:26217789 NCBI chr 9:45,605,552...45,616,912
Ensembl chr 9:45,605,552...45,616,912 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of NOS2 mRNA] CTD PMID:16604421 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO [Thalidomide co-treated with Dexamethasone] results in increased expression of NPPB protein CTD PMID:18414984 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 decreases expression ISO Thalidomide results in decreased expression of NQO2 mRNA CTD PMID:26217789 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression ISO Thalidomide results in increased expression of NR1I2 mRNA CTD PMID:28496040 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Thalidomide analog results in increased expression of NR4A1 mRNA CTD PMID:20525221 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 increases expression ISO Thalidomide analog results in increased expression of NR4A2 mRNA CTD PMID:20525221 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159 		JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858 		JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087 		JBrowse link
G Nt5c3a 5'-nucleotidase, cytosolic IIIA decreases expression ISO Thalidomide results in decreased expression of NT5C3 mRNA CTD PMID:26217789 NCBI chr 4:87,238,325...87,281,234
Ensembl chr 4:87,237,949...87,281,157 		JBrowse link
G Nt5e 5' nucleotidase, ecto decreases expression ISO Thalidomide results in decreased expression of NT5E mRNA CTD PMID:26217789 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696 		JBrowse link
G Nudt14 nudix hydrolase 14 decreases expression ISO Thalidomide results in decreased expression of NUDT14 mRNA CTD PMID:26217789 NCBI chr 6:137,738,150...137,745,143
Ensembl chr 6:137,738,124...137,745,127 		JBrowse link
G Nudt22 nudix hydrolase 22 decreases expression ISO Thalidomide results in decreased expression of NUDT22 mRNA CTD PMID:26217789 NCBI chr 1:222,247,500...222,251,053
Ensembl chr 1:222,247,502...222,250,980 		JBrowse link
G Nup62cl nucleoporin 62 C-terminal like decreases expression ISO Thalidomide results in decreased expression of NUP62CL mRNA CTD PMID:26217789 NCBI chr  X:111,333,274...111,390,023
Ensembl chr  X:111,334,252...111,365,849 		JBrowse link
G Nusap1 nucleolar and spindle associated protein 1 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of NUSAP1 mRNA CTD PMID:18720364 NCBI chr 3:111,422,267...111,452,600
Ensembl chr 3:111,422,267...111,452,971 		JBrowse link
G Ocln occludin multiple interactions ISO Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of OCLN protein] CTD PMID:16680017 NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 increases expression ISO Thalidomide results in increased expression of OLIG2 mRNA CTD PMID:26217789 NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890 		JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Thalidomide results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835 		JBrowse link
G Olr1194 olfactory receptor 1194 decreases expression ISO Thalidomide results in decreased expression of OLFR160 mRNA CTD PMID:26217789 NCBI chr 8:40,191,902...40,192,831
Ensembl chr 8:40,191,902...40,192,831 		JBrowse link
G Olr1235 olfactory receptor 1235 increases expression ISO Thalidomide results in increased expression of OLFR147 mRNA CTD PMID:26217789 NCBI chr 4:1,470,716...1,471,657
Ensembl chr 4:1,470,716...1,471,657 		JBrowse link
G Olr137 olfactory receptor 137 increases expression ISO Thalidomide results in increased expression of OLFR635 mRNA CTD PMID:26217789 NCBI chr 1:169,153,297...169,154,262
Ensembl chr 1:169,153,297...169,154,262 		JBrowse link
G Olr1394 olfactory receptor 1394 increases expression ISO Thalidomide results in increased expression of OLFR1385 mRNA CTD PMID:26217789 NCBI chr10:34,672,726...34,673,655
Ensembl chr10:34,672,726...34,673,655 		JBrowse link
G Olr1519 olfactory receptor 1519 increases expression ISO Thalidomide results in increased expression of OLFR412 mRNA CTD PMID:26217789 NCBI chr10:61,160,125...61,161,060
Ensembl chr10:61,160,125...61,161,060
Ensembl chr10:61,160,125...61,161,060 		JBrowse link
G Olr217 olfactory receptor 217 increases expression ISO Thalidomide results in increased expression of OLFR705 mRNA CTD PMID:26217789 NCBI chr 1:170,915,109...170,916,059
Ensembl chr 1:170,915,109...170,916,059 		JBrowse link
G Olr374 olfactory receptor 374 increases expression ISO Thalidomide results in increased expression of OLFR1494 mRNA CTD PMID:26217789 NCBI chr 1:230,576,298...230,577,254
Ensembl chr 1:230,576,298...230,577,254 		JBrowse link
G Olr588 olfactory receptor 588 increases expression ISO Thalidomide results in increased expression of OLFR152 mRNA CTD PMID:26217789 NCBI chr 3:75,936,795...75,937,739
Ensembl chr 3:75,936,795...75,937,739 		JBrowse link
G Ostf1 osteoclast stimulating factor 1 decreases expression ISO Thalidomide results in decreased expression of OSTF1 mRNA CTD PMID:26217789 NCBI chr 1:234,749,568...234,796,739
Ensembl chr 1:234,749,568...234,796,739 		JBrowse link
G Pabir1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 decreases expression ISO Thalidomide results in decreased expression of FAM122A mRNA CTD PMID:26217789 NCBI chr 1:242,372,458...242,373,764
Ensembl chr 1:242,372,458...242,373,764 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO [Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein
Thalidomide analog results in increased cleavage of PARP1 protein		 CTD PMID:15858615 PMID:19372569 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pax3 paired box 3 decreases expression ISO Thalidomide results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172 		JBrowse link
G Pax6 paired box 6 increases expression ISO Thalidomide results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624 		JBrowse link
G Pdcd10 programmed cell death 10 decreases expression ISO Thalidomide results in decreased expression of PDCD10 mRNA CTD PMID:26217789 NCBI chr 2:173,966,701...174,012,730
Ensembl chr 2:173,967,080...174,012,676 		JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression ISO Thalidomide results in decreased expression of PDLIM3 mRNA CTD PMID:26217789 NCBI chr16:49,543,140...49,574,362
Ensembl chr16:49,543,142...49,574,390 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression EXP Thalidomide results in decreased expression of PECAM1 protein CTD PMID:18291259 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pfdn6 prefoldin subunit 6 decreases expression ISO Thalidomide results in decreased expression of PFDN6 mRNA CTD PMID:26217789 NCBI chr20:5,455,974...5,457,448
Ensembl chr20:5,455,974...5,457,444 		JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions ISO [ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite CTD PMID:28745489 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454 		JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha decreases expression ISO Thalidomide results in decreased expression of PILRA mRNA CTD PMID:26217789 NCBI chr12:21,412,598...21,418,621
Ensembl chr12:21,412,538...21,420,169 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression ISO Thalidomide results in decreased expression of PIM1 protein CTD PMID:16616857 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO Thalidomide results in decreased expression of PLAU protein CTD PMID:16288038 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819 		JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions
decreases expression		 ISO Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]
Thalidomide results in decreased expression of PLAUR protein		 CTD PMID:16288038 NCBI chr 1:81,328,171...81,344,954
Ensembl chr 1:81,328,183...81,344,708 		JBrowse link
G Pltp phospholipid transfer protein decreases expression ISO Thalidomide results in decreased expression of PLTP mRNA CTD PMID:26217789 NCBI chr 3:161,304,469...161,322,289
Ensembl chr 3:161,304,469...161,322,289 		JBrowse link
G Polr2k RNA polymerase II, I and III subunit K decreases expression ISO Thalidomide results in decreased expression of POLR2K mRNA CTD PMID:26217789 NCBI chr 7:74,939,010...74,992,594
Ensembl chr 7:74,989,223...74,992,582 		JBrowse link
G Popdc2 popeye domain containing 2 decreases expression ISO Thalidomide results in decreased expression of POPDC2 mRNA CTD PMID:26217789 NCBI chr11:64,915,041...64,954,704
Ensembl chr11:64,936,692...64,952,687 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases response to substance ISO PPARD gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Ppp1r11 protein phosphatase 1, regulatory (inhibitor) subunit 11 decreases expression ISO Thalidomide results in decreased expression of PPP1R11 mRNA CTD PMID:26217789 NCBI chr20:2,094,931...2,098,438
Ensembl chr20:2,094,931...2,098,433 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Thalidomide analog results in increased expression of PPP1R15A mRNA CTD PMID:20525221 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974 		JBrowse link
G Ppp1r1a protein phosphatase 1, regulatory (inhibitor) subunit 1A decreases expression ISO Thalidomide results in decreased expression of PPP1R1A mRNA CTD PMID:26217789 NCBI chr 7:145,146,480...145,154,131
Ensembl chr 7:145,146,481...145,154,131 		JBrowse link
G Prelid2 PRELI domain containing 2 decreases expression ISO Thalidomide results in decreased expression of PRELID2 mRNA CTD PMID:26217789 NCBI chr18:36,198,522...36,286,217
Ensembl chr18:36,194,778...36,285,444 		JBrowse link
G Prf1 perforin 1 increases expression ISO Thalidomide results in increased expression of PRF1 CTD PMID:17089043 NCBI chr20:30,915,294...30,920,804
Ensembl chr20:30,915,213...30,921,382 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression ISO Thalidomide results in decreased expression of PRKG1 mRNA CTD PMID:26217789 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Prr5 proline rich 5 decreases expression ISO Thalidomide results in decreased expression of PRR5 mRNA CTD PMID:26217789 NCBI chr 7:125,569,791...125,609,340
Ensembl chr 7:125,576,327...125,613,114 		JBrowse link
G Prxl2a peroxiredoxin like 2A decreases expression ISO Thalidomide results in decreased expression of PRXL2A mRNA CTD PMID:26217789 NCBI chr16:17,494,000...17,513,781
Ensembl chr16:17,493,953...17,513,870 		JBrowse link
G Psme2 proteasome activator subunit 2 increases expression ISO Thalidomide results in increased expression of PSME2 mRNA CTD PMID:26217789 NCBI chr15:34,265,552...34,269,851
Ensembl chr15:34,265,557...34,269,851 		JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Thalidomide results in increased expression of PTEN protein CTD PMID:19567134 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases degradation
decreases stability
multiple interactions
decreases expression		 ISO
EXP		 Thalidomide results in increased degradation of PTGS2 protein
Thalidomide results in decreased stability of PTGS2 mRNA
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Thalidomide inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]
Thalidomide results in decreased expression of PTGS2 protein		 CTD PMID:11705847 PMID:15982930 PMID:17638016 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rab2b RAB2B, member RAS oncogene family decreases expression ISO Thalidomide results in decreased expression of RAB2B mRNA CTD PMID:26006729 PMID:26217789 NCBI chr15:28,675,504...28,696,192
Ensembl chr15:28,677,055...28,696,122 		JBrowse link
G Rab8a RAB8A, member RAS oncogene family decreases expression ISO Thalidomide results in decreased expression of RAB8A mRNA CTD PMID:26006729 NCBI chr16:19,355,047...19,376,776
Ensembl chr16:19,355,048...19,376,776 		JBrowse link
G Rap1b RAP1B, member of RAS oncogene family decreases expression ISO Thalidomide results in decreased expression of RAP1B mRNA CTD PMID:26006729 NCBI chr 7:60,850,406...60,878,226
Ensembl chr 7:60,853,930...60,860,990 		JBrowse link
G Rassf9 Ras association domain family member 9 decreases expression ISO Thalidomide results in decreased expression of RASSF9 mRNA CTD PMID:26217789 NCBI chr 7:44,146,345...44,178,179
Ensembl chr 7:44,146,237...44,181,201 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 ISO
EXP		 [irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; [irinotecan co-treated with Thalidomide] results in increased expression of RELA protein; [resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Paraquat affects the localization of RELA protein]
Thalidomide results in decreased expression of RELA protein
[Thalidomide co-treated with Dimethylnitrosamine] results in decreased transport of RELA protein; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]		 CTD PMID:15687330 PMID:16078585 PMID:16333628 PMID:16604421 PMID:16685529 PMID:16943688 PMID:17030452 PMID:17164350 PMID:17174718 PMID:23510834 PMID:26051520 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Thalidomide analog results in increased expression of RELB mRNA CTD PMID:20525221 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825 		JBrowse link
G Rfc3 replication factor C subunit 3 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of RFC3 mRNA CTD PMID:18720364 NCBI chr12:1,460,581...1,471,344
Ensembl chr12:1,460,538...1,471,357 		JBrowse link
G Rhoa ras homolog family member A affects expression ISO Thalidomide affects the expression of RHOA mRNA CTD PMID:26006729 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G Rnaseh2c ribonuclease H2, subunit C decreases expression ISO Thalidomide results in decreased expression of RNASEH2C mRNA CTD PMID:26217789 NCBI chr 1:220,966,626...220,967,717
Ensembl chr 1:220,966,655...220,967,825 		JBrowse link
G Rnf138 ring finger protein 138 decreases expression ISO Thalidomide results in decreased expression of RNF138 mRNA CTD PMID:26217789 NCBI chr18:15,146,925...15,167,361 JBrowse link
G Rnf166 ring finger protein 166 multiple interactions ISO Thalidomide results in increased degradation of and results in decreased expression of RNF166 protein CTD PMID:30067223 NCBI chr19:55,290,563...55,300,403
Ensembl chr19:55,290,563...55,300,403 		JBrowse link
G Rps15 ribosomal protein S15 increases expression ISO Thalidomide results in increased expression of RPS15 mRNA CTD PMID:26217789 NCBI chr 7:12,282,134...12,283,573
Ensembl chr 7:12,282,109...12,283,608 		JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 decreases expression ISO Thalidomide results in decreased expression of RPS6KA2 mRNA CTD PMID:26217789 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445 		JBrowse link
G Rras RAS related decreases expression ISO Thalidomide results in decreased expression of RRAS mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 1:101,012,822...101,016,720
Ensembl chr 1:101,012,822...101,016,720 		JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA CTD PMID:18720364 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515 		JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression ISO Thalidomide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818 		JBrowse link
G Rtn2 reticulon 2 decreases expression ISO Thalidomide results in decreased expression of RTN2 mRNA CTD PMID:26217789 NCBI chr 1:80,195,594...80,208,449
Ensembl chr 1:80,195,532...80,208,448 		JBrowse link
G Ryr2 ryanodine receptor 2 decreases expression ISO Thalidomide results in decreased expression of RYR2 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606 		JBrowse link
G Sall4 spalt-like transcription factor 4 increases expression
affects binding
multiple interactions		 ISO Thalidomide results in increased expression of SALL4 mRNA
Thalidomide binds to [SALL4 protein binds to CRBN protein]
Bortezomib inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; MLN7243 inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; pevonedistat inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein		 CTD PMID:30067223 NCBI chr 3:165,520,155...165,538,176
Ensembl chr 3:165,520,392...165,537,940 		JBrowse link
G Sap30 Sin3A associated protein 30 decreases expression ISO Thalidomide results in decreased expression of SAP30 mRNA CTD PMID:26217789 NCBI chr16:36,115,942...36,121,310
Ensembl chr16:36,116,258...36,121,097 		JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 decreases expression ISO Thalidomide results in decreased expression of SAT1 mRNA CTD PMID:26217789 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765 		JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 decreases expression ISO Thalidomide results in decreased expression of SCN7A mRNA CTD PMID:26217789 NCBI chr 3:52,775,779...52,877,365
Ensembl chr 3:52,777,214...52,849,907 		JBrowse link
G Sdhaf1 succinate dehydrogenase complex assembly factor 1 decreases expression ISO Thalidomide results in decreased expression of SDHAF1 mRNA CTD PMID:26217789 NCBI chr 1:88,779,476...88,780,425
Ensembl chr 1:90,948,976...90,949,332 		JBrowse link
G Sdhc succinate dehydrogenase complex subunit C decreases expression ISO Thalidomide results in decreased expression of SDHC mRNA CTD PMID:26217789 NCBI chr13:89,498,047...89,518,979
Ensembl chr13:89,498,048...89,518,939 		JBrowse link
G Selenos selenoprotein S decreases expression ISO Thalidomide results in decreased expression of SELENOS mRNA CTD PMID:26006729 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344 		JBrowse link
G Sell selectin L decreases expression ISO Thalidomide results in decreased expression of SELL protein CTD PMID:16344495 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631 		JBrowse link
G Serpinb2 serpin family B member 2 increases response to substance ISO SERPINB2 gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr13:27,449,907...27,463,015
Ensembl chr13:27,449,934...27,463,010 		JBrowse link
G Sfrp2 secreted frizzled-related protein 2 increases expression ISO Thalidomide results in increased expression of SFRP2 mRNA CTD PMID:26217789 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764 		JBrowse link
G Sh3bgr SH3 domain binding glutamate-rich protein decreases expression ISO Thalidomide results in decreased expression of SH3BGR mRNA CTD PMID:26217789 NCBI chr11:36,555,354...36,579,537
Ensembl chr11:36,555,416...36,579,535 		JBrowse link
G Slc12a6 solute carrier family 12, member 6 increases response to substance ISO SLC12A6 gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr 3:103,752,213...103,852,686
Ensembl chr 3:103,753,238...103,852,686 		JBrowse link
G Slc13a4 solute carrier family 13 member 4 decreases expression ISO Thalidomide results in decreased expression of SLC13A4 mRNA CTD PMID:26217789 NCBI chr 4:62,796,732...62,841,053
Ensembl chr 4:62,797,677...62,840,357 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Thalidomide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc25a20 solute carrier family 25 member 20 decreases expression ISO Thalidomide results in decreased expression of SLC25A20 mRNA CTD PMID:26217789 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734 		JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression ISO Thalidomide results in decreased expression of SLC25A30 mRNA CTD PMID:26217789 NCBI chr15:57,811,612...57,834,173
Ensembl chr15:57,813,356...57,834,173 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 increases expression ISO Thalidomide results in increased expression of SLC2A3 mRNA CTD PMID:26217789 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856 		JBrowse link
G Slc44a3 solute carrier family 44, member 3 decreases expression ISO Thalidomide results in decreased expression of SLC44A3 mRNA CTD PMID:26217789 NCBI chr 2:225,038,261...225,112,859
Ensembl chr 2:225,038,582...225,107,283 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 decreases expression ISO Thalidomide results in decreased expression of SLC8A1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604 		JBrowse link
G Slco4c1 solute carrier organic anion transporter family, member 4C1 decreases expression ISO Thalidomide results in decreased expression of SLCO4C1 mRNA CTD PMID:26217789 NCBI chr 9:104,301,935...104,350,262
Ensembl chr 9:104,299,277...104,350,308 		JBrowse link
G Smim4 small integral membrane protein 4 decreases expression ISO Thalidomide results in decreased expression of SMIM4 mRNA CTD PMID:26217789 NCBI chr16:7,206,632...7,210,518 JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120 		JBrowse link
G Smyd1 SET and MYND domain containing 1 decreases expression ISO Thalidomide results in decreased expression of SMYD1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 4:99,071,122...99,125,143
Ensembl chr 4:99,074,535...99,125,111 		JBrowse link
G Snap25 synaptosome associated protein 25 increases expression EXP Thalidomide results in increased expression of SNAP25 mRNA; Thalidomide results in increased expression of SNAP25 protein CTD PMID:27693314 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400 		JBrowse link
G Snrpd1 small nuclear ribonucleoprotein D1 polypeptide decreases expression ISO Thalidomide results in decreased expression of SNRPD1 mRNA CTD PMID:26217789 NCBI chr18:1,866,066...1,876,613
Ensembl chr18:1,866,080...1,876,613 		JBrowse link
G Snx16 sorting nexin 16 increases expression ISO Thalidomide analog results in increased expression of SNX16 mRNA CTD PMID:20525221 NCBI chr 2:93,518,796...93,541,056
Ensembl chr 2:93,518,806...93,540,328 		JBrowse link
G Snx24 sorting nexin 24 decreases expression ISO Thalidomide results in decreased expression of SNX24 mRNA CTD PMID:26217789 NCBI chr18:48,201,653...48,355,701
Ensembl chr18:48,201,728...48,355,699 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO
EXP		 Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]
Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]		 CTD PMID:16510725 PMID:17030452 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sox1 SRY-box transcription factor 1 decreases expression ISO Thalidomide results in decreased expression of SOX1 mRNA CTD PMID:26217789
G Sox17 SRY-box transcription factor 17 decreases localization ISO Thalidomide results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 5:14,890,318...14,895,907
Ensembl chr 5:14,890,408...14,895,907 		JBrowse link
G Sp1 Sp1 transcription factor decreases activity ISO Thalidomide results in decreased activity of SP1 protein CTD PMID:10533722 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
G Sp5 Sp5 transcription factor decreases expression ISO Thalidomide results in decreased expression of SP5 mRNA CTD PMID:26217789 NCBI chr 3:56,766,475...56,769,277
Ensembl chr 3:56,766,475...56,769,277 		JBrowse link
G Spa17 sperm autoantigenic protein 17 decreases expression ISO Thalidomide results in decreased expression of SPA17 mRNA CTD PMID:26217789 NCBI chr 8:40,066,954...40,078,131
Ensembl chr 8:40,067,076...40,078,165 		JBrowse link
G Spag5 sperm associated antigen 5 multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of SPAG5 mRNA CTD PMID:18720364 NCBI chr10:65,552,780...65,585,773
Ensembl chr10:65,566,171...65,585,760
Ensembl chr10:65,566,171...65,585,760 		JBrowse link
G Sphkap SPHK1 interactor, AKAP domain containing decreases expression ISO Thalidomide results in decreased expression of SPHKAP mRNA CTD PMID:26217789 NCBI chr 9:89,050,405...89,195,435
Ensembl chr 9:89,050,381...89,195,273 		JBrowse link
G Srrd SRR1 domain containing decreases expression ISO Thalidomide results in decreased expression of SRRD mRNA CTD PMID:26217789 NCBI chr12:50,315,876...50,321,488
Ensembl chr12:50,315,933...50,321,144 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions		 ISO Thalidomide analog results in decreased phosphorylation of STAT3 protein
[resveratrol co-treated with Thalidomide] results in decreased phosphorylation of STAT3 protein; Thalidomide promotes the reaction [Capsaicin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]		 CTD PMID:15858615 PMID:17164350 PMID:17505005 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Stmn2 stathmin 2 decreases expression ISO Thalidomide results in decreased expression of STMN2 mRNA CTD PMID:26217789 NCBI chr 2:95,424,251...95,471,900
Ensembl chr 2:95,424,251...95,472,115 		JBrowse link
G Swsap1 SWIM-type zinc finger 7 associated protein 1 decreases expression ISO Thalidomide results in decreased expression of SWSAP1 mRNA CTD PMID:26217789 NCBI chr 8:22,966,752...22,969,280
Ensembl chr 8:22,966,561...22,969,459 		JBrowse link
G Synj2bp synaptojanin 2 binding protein decreases expression ISO Thalidomide results in decreased expression of SYNJ2BP mRNA CTD PMID:26006729 NCBI chr 6:105,224,166...105,261,549
Ensembl chr 6:105,224,166...105,261,549 		JBrowse link
G Tc2n tandem C2 domains, nuclear decreases expression ISO Thalidomide results in decreased expression of TC2N mRNA CTD PMID:26217789 NCBI chr 6:125,437,767...125,601,408
Ensembl chr 6:125,437,775...125,590,049 		JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Thalidomide results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504 		JBrowse link
G Tdg thymine-DNA glycosylase decreases expression ISO Thalidomide results in decreased expression of TDG mRNA CTD PMID:26217789 NCBI chr 7:27,194,000...27,213,676
Ensembl chr 7:27,193,998...27,214,236 		JBrowse link
G Tdgf1 teratocarcinoma-derived growth factor 1 decreases expression ISO Thalidomide results in decreased expression of TDGF1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 8:119,215,266...119,220,909
Ensembl chr 8:119,215,495...119,219,232 		JBrowse link
G Tefm transcription elongation factor, mitochondrial decreases expression ISO Thalidomide results in decreased expression of TEFM mRNA CTD PMID:26217789 NCBI chr10:67,476,006...67,478,830
Ensembl chr10:67,475,968...67,479,077 		JBrowse link
G Tek TEK receptor tyrosine kinase decreases expression ISO Thalidomide results in decreased expression of TEK mRNA CTD PMID:15618473 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799 		JBrowse link
G Tex16-ps1 testis expressed 16, pseudogene 1 decreases expression ISO Thalidomide results in decreased expression of TEX16 mRNA CTD PMID:26217789
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 ISO
EXP		 Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]
Thalidomide results in decreased expression of TGFB1 mRNA
Thalidomide results in decreased expression of TGFB1 mRNA; Thalidomide results in decreased expression of TGFB1 protein
Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]		 CTD PMID:15464241 PMID:16288038 PMID:16510725 PMID:16549389 PMID:16604421 PMID:17030452 PMID:18291259 PMID:26006729 PMID:26217789 PMID:26221080 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tgfbi transforming growth factor, beta induced decreases expression ISO Thalidomide results in decreased expression of TGFBI mRNA CTD PMID:26006729 PMID:26217789 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO Thalidomide results in decreased expression of TGFBR1 mRNA; Thalidomide results in decreased expression of TGFBR1 protein CTD PMID:15618473 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA] CTD PMID:15464241 PMID:17030452 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA] CTD PMID:15464241 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tinagl1 tubulointerstitial nephritis antigen-like 1 decreases expression ISO Thalidomide results in decreased expression of TINAGL1 mRNA CTD PMID:26217789 NCBI chr 5:148,382,702...148,392,729
Ensembl chr 5:148,382,706...148,392,697 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of TJP1 protein] CTD PMID:16680017 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469 		JBrowse link
G Tm2d3 TM2 domain containing 3 decreases expression ISO Thalidomide results in decreased expression of TM2D3 mRNA CTD PMID:26217789 NCBI chr 1:126,573,474...126,595,778
Ensembl chr 1:126,586,543...126,595,603 		JBrowse link
G Tmem138 transmembrane protein 138 decreases expression ISO Thalidomide results in decreased expression of TMEM138 mRNA CTD PMID:26217789 NCBI chr 1:226,623,861...226,630,911
Ensembl chr 1:226,623,861...226,630,900 		JBrowse link
G Tmem176a transmembrane protein 176A decreases expression ISO Thalidomide results in decreased expression of TMEM176A mRNA CTD PMID:26217789 NCBI chr 4:78,458,735...78,462,415
Ensembl chr 4:78,458,625...78,462,423 		JBrowse link
G Tmpo thymopoietin multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNA CTD PMID:18720364 NCBI chr 7:31,847,412...31,872,416
Ensembl chr 7:31,847,410...31,872,423 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
increases degradation
increases expression		 ISO
EXP		 Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Endotoxins results in increased expression of TNF protein]; Thalidomide inhibits the reaction [lipophosphonoglycan results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
Thalidomide results in decreased expression of TNF protein
Thalidomide results in decreased expression of TNF mRNA; Thalidomide results in decreased expression of TNF protein
Thalidomide results in increased degradation of TNF mRNA
Thalidomide results in increased expression of TNF mRNA
Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [irinotecan results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [irinotecan results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF protein]
Thalidomide results in increased expression of TNF protein
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]		 CTD PMID:9068814 PMID:9623511 PMID:10496904 PMID:10720640 PMID:11367517 PMID:11592764 PMID:11788559 PMID:12411981 PMID:12422154 PMID:14617101 PMID:14687169 PMID:15060740 PMID:15464241 PMID:15687330 PMID:15863203 PMID:15982930 PMID:16078585 PMID:16454849 PMID:16510725 PMID:16549389 PMID:16597438 PMID:16604421 PMID:16680017 PMID:16815871 PMID:16943688 PMID:18291259 PMID:19050852 PMID:23510834 PMID:25478868 PMID:26051520 PMID:26221080 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b decreases expression ISO Thalidomide results in decreased expression of TNFRSF10A protein CTD PMID:16531263 NCBI chr15:51,433,853...51,464,215 JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression ISO Thalidomide results in decreased expression of TNFRSF1A mRNA; Thalidomide results in decreased expression of TNFRSF1A protein CTD PMID:15618473 PMID:16344495 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases expression ISO Thalidomide results in decreased expression of TNFRSF1B mRNA CTD PMID:15618473 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299 		JBrowse link
G Tnfsf10 TNF superfamily member 10 decreases expression ISO Thalidomide results in decreased expression of TNFSF10 protein CTD PMID:16531263 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO [Thalidomide co-treated with Dexamethasone] results in decreased expression of TNFSF11 protein CTD PMID:16079895 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704 		JBrowse link
G Tnnc1 troponin C1, slow skeletal and cardiac type decreases expression ISO Thalidomide results in decreased expression of TNNC1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr16:7,292,207...7,295,238
Ensembl chr16:7,292,096...7,295,465 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA CTD PMID:18720364 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Thalidomide analog results in increased expression of TP53 mRNA CTD PMID:20525221 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 decreases expression ISO Thalidomide results in decreased expression of TRAM1L1 mRNA CTD PMID:26217789 NCBI chr 2:228,544,418...228,546,599
Ensembl chr 2:228,544,418...228,546,599 		JBrowse link
G Trappc2l trafficking protein particle complex 2-like decreases expression ISO Thalidomide results in decreased expression of TRAPPC2L mRNA CTD PMID:26217789 NCBI chr19:55,423,350...55,428,551
Ensembl chr19:55,423,350...55,427,036 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Thalidomide analog results in increased expression of TRIB3 mRNA CTD PMID:20525221 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
G Trim55 tripartite motif-containing 55 decreases expression ISO Thalidomide results in decreased expression of TRIM55 mRNA CTD PMID:26217789 NCBI chr 2:104,416,972...104,459,117
Ensembl chr 2:104,416,972...104,459,107 		JBrowse link
G Tspan33 tetraspanin 33 decreases expression ISO Thalidomide results in decreased expression of TSPAN33 mRNA CTD PMID:26217789 NCBI chr 4:56,981,283...57,005,866
Ensembl chr 4:56,981,283...57,004,792 		JBrowse link
G Ttc30a1 tetratricopeptide repeat domain 30A1 decreases expression ISO Thalidomide results in decreased expression of TTC30A1 mRNA CTD PMID:26217789 NCBI chr 3:62,800,932...62,803,373
Ensembl chr 3:62,800,935...62,803,373 		JBrowse link
G Ttc32 tetratricopeptide repeat domain 32 decreases expression ISO Thalidomide results in decreased expression of TTC32 mRNA CTD PMID:26217789 NCBI chr 6:34,154,973...34,161,857
Ensembl chr 6:34,155,017...34,161,171 		JBrowse link
G Ttk Ttk protein kinase multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNA CTD PMID:18720364 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993 		JBrowse link
G Ttn titin decreases expression ISO Thalidomide results in decreased expression of TTN mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 3:63,565,160...63,837,815 JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C multiple interactions ISO [Azacitidine co-treated with Thalidomide] affects the expression of UBE2C mRNA CTD PMID:18720364 NCBI chr 3:161,236,971...161,239,371
Ensembl chr 3:161,236,898...161,241,159 		JBrowse link
G Ubxn1 UBX domain protein 1 decreases expression ISO Thalidomide results in decreased expression of UBXN1 mRNA CTD PMID:26217789 NCBI chr 1:225,067,953...225,071,944
Ensembl chr 1:225,068,009...225,071,945 		JBrowse link
G Uchl3 ubiquitin C-terminal hydrolase L3 decreases expression ISO Thalidomide results in decreased expression of UCHL3 mRNA CTD PMID:26217789 NCBI chr15:86,153,624...86,198,127
Ensembl chr15:86,153,628...86,198,127 		JBrowse link
G Uncx UNC homeobox decreases expression ISO Thalidomide results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:17,182,158...17,186,679
Ensembl chr12:17,182,163...17,186,679 		JBrowse link
G Upp1 uridine phosphorylase 1 decreases expression ISO Thalidomide results in decreased expression of UPP1 mRNA CTD PMID:26217789 NCBI chr14:89,314,234...89,334,060
Ensembl chr14:89,314,176...89,334,276 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression EXP Thalidomide results in decreased expression of VCAM1 mRNA; Thalidomide results in decreased expression of VCAM1 protein CTD PMID:17174718 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
G Vegfa vascular endothelial growth factor A affects expression
multiple interactions
decreases expression
increases expression
decreases activity
decreases secretion
affects secretion		 ISO
EXP		 Thalidomide affects the expression of VEGFA mRNA; Thalidomide affects the expression of VEGFA protein
[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFA mRNA
[temozolomide co-treated with Thalidomide] results in decreased expression of VEGFA protein
Thalidomide results in decreased expression of VEGFA protein
Thalidomide results in decreased expression of VEGFA mRNA
[Thalidomide co-treated with Paclitaxel] results in decreased expression of VEGFA mRNA
Thalidomide results in increased expression of VEGFA protein
Thalidomide results in decreased expression of VEGFA mRNA; Thalidomide results in decreased expression of VEGFA protein
Thalidomide results in decreased activity of VEGFA protein
Thalidomide analog results in decreased secretion of VEGFA protein
Thalidomide affects the secretion of VEGFA protein		 CTD PMID:15858615 PMID:15863203 PMID:15939924 PMID:15982930 PMID:16313753 PMID:16327979 PMID:17557286 PMID:18291259 PMID:21539454 PMID:24154490 PMID:29699374 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vegfb vascular endothelial growth factor B multiple interactions
decreases expression		 ISO [Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFB mRNA
Thalidomide results in decreased expression of VEGFB mRNA		 CTD PMID:29699374 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644 		JBrowse link
G Vegfc vascular endothelial growth factor C affects expression ISO Thalidomide affects the expression of VEGFC mRNA CTD PMID:29699374 NCBI chr16:40,440,371...40,555,178
Ensembl chr16:40,440,207...40,555,576 		JBrowse link
G Vegfd vascular endothelial growth factor D multiple interactions
decreases expression		 ISO [Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFD mRNA
Thalidomide results in decreased expression of VEGFD mRNA		 CTD PMID:29699374 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715 		JBrowse link
G Vtn vitronectin decreases expression ISO Thalidomide results in decreased expression of VTN mRNA CTD PMID:26217789 NCBI chr10:65,767,960...65,771,040
Ensembl chr10:65,767,053...65,771,038 		JBrowse link
G Wnt5b Wnt family member 5B decreases expression ISO Thalidomide results in decreased expression of WNT5B mRNA CTD PMID:24154490 NCBI chr 4:151,500,962...151,516,894
Ensembl chr 4:151,500,957...151,516,894 		JBrowse link
G Wnt8a Wnt family member 8A decreases expression ISO Thalidomide results in decreased expression of WNT8A mRNA CTD PMID:26217789 NCBI chr18:27,331,236...27,336,829
Ensembl chr18:27,331,236...27,336,829 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO Thalidomide analog results in decreased expression of XIAP protein CTD PMID:15858615 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
G Zcchc17 zinc finger CCHC-type containing 17 increases expression ISO Thalidomide results in increased expression of ZCCHC17 mRNA CTD PMID:26217789 NCBI chr 5:148,535,519...148,577,315
Ensembl chr 5:148,535,519...148,577,292 		JBrowse link
G Zfp692 zinc finger protein 692 multiple interactions ISO Thalidomide results in increased degradation of and results in decreased expression of ZNF692 protein CTD PMID:30067223 NCBI chr10:43,740,739...43,752,713
Ensembl chr10:43,744,731...43,752,242 		JBrowse link
G Zfpl1 zinc finger protein-like 1 decreases expression ISO Thalidomide results in decreased expression of ZFPL1 mRNA CTD PMID:26217789 NCBI chr 1:221,444,588...221,448,555
Ensembl chr 1:221,443,901...221,448,570 		JBrowse link
G Zkscan5 zinc finger with KRAB and SCAN domains 5 decreases expression ISO Thalidomide results in decreased expression of ZKSCAN5 mRNA CTD PMID:26217789 NCBI chr12:11,154,807...11,176,002
Ensembl chr12:11,154,794...11,176,106 		JBrowse link
G Zmat5 zinc finger, matrin type 5 decreases expression ISO Thalidomide results in decreased expression of ZMAT5 mRNA CTD PMID:26217789 NCBI chr14:84,937,843...84,968,898
Ensembl chr14:84,953,786...84,969,116 		JBrowse link
G Znrd2 zinc ribbon domain containing 2 decreases expression ISO Thalidomide results in decreased expression of ZNRD2 mRNA CTD PMID:26217789 NCBI chr 1:221,087,803...221,089,586
Ensembl chr 1:221,087,803...221,089,586 		JBrowse link
G Zscan12 zinc finger and SCAN domain containing 12 decreases expression ISO Thalidomide results in decreased expression of ZSCAN12 mRNA CTD PMID:26217789 NCBI chr17:45,279,171...45,285,069
Ensembl chr17:45,279,162...45,285,060 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        aetiopathogenetic role 18974
          teratogenic agent 15884
            (S)-thalidomide 453
              thalidomide + 453
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                organic heterocyclic compound 18486
                                  organic heteropolycyclic compound 17874
                                    organic heterobicyclic compound 16808
                                      benzopyrrole 9537
                                        isoindoles 1115
                                          phthalimides 989
                                            2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione 453
                                              (S)-thalidomide 453
                                                thalidomide + 453
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