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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbimazole
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Accession:CHEBI:617099 term browser browse the term
Definition:A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.
Synonyms:exact_synonym: ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate
 related_synonym: Athyromazole;   Carbethoxymethimazole;   Carbinazole;   Ethyl 3-methyl-2-thioimidazoline-1-carboxylate;   Formula=C7H10N2O2S;   InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3;   InChIKey=CFOYWRHIYXMDOT-UHFFFAOYSA-N;   SMILES=CCOC(=O)n1ccn(C)c1=S;   Thyrostat;   carbimazol;   carbimazolum
 alt_id: CHEBI:3397
 xref: CAS:22232-54-8;   DrugBank:DB00389;   Drug_Central:497;   KEGG:C07615;   KEGG:D07616;   LINCS:LSM-5930
 xref_mesh: MESH:D002231
 xref: PMID:1502708;   PMID:18954039;   PMID:23343442;   PMID:23391946;   PMID:23776913;   PMID:23900475;   PMID:24049063;   PMID:24255992;   PMID:24265129;   PMID:25013255;   Patent:US2671088;   Patent:US2815349;   Reaxys:144339;   VSDB:1876;   Wikipedia:Carbimazole



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carbimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
decreases expression
EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of AR mRNA] CTD PMID:38342389 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Carbimazole results in increased expression of CASP3 mRNA
Thioctic Acid inhibits the reaction [Carbimazole results in increased expression of CASP3 mRNA]
CTD PMID:38342389 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased activity of CAT protein] CTD PMID:38342389 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ckm creatine kinase, M-type increases expression ISO Carbimazole results in increased expression of CKM protein CTD PMID:2565460 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased activity of GSR protein] CTD PMID:38342389 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression
EXP Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of NFE2L2 mRNA] CTD PMID:38342389 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression
multiple interactions
EXP Carbimazole results in decreased expression of SRD5A1 mRNA
Thioctic Acid inhibits the reaction [Carbimazole results in decreased expression of SRD5A1 mRNA]
CTD PMID:38342389 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19863
    role 19835
      application 19677
        pro-agent 11550
          prodrug 11311
            carbimazole 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19863
    subatomic particle 19861
      composite particle 19861
        hadron 19861
          baryon 19861
            nucleon 19861
              atomic nucleus 19861
                atom 19861
                  main group element atom 19807
                    p-block element atom 19807
                      carbon group element atom 19748
                        carbon atom 19744
                          organic molecular entity 19744
                            organic molecule 19695
                              organic cyclic compound 19506
                                organic heterocyclic compound 18878
                                  heteroarene 17154
                                    monocyclic heteroarene 14923
                                      azole 14437
                                        diazole 10534
                                          imidazoles 9948
                                            1,3-dihydroimidazole-2-thiones 3630
                                              carbimazole 7
paths to the root