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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbimazole
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Accession:CHEBI:617099 term browser browse the term
Definition:A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.
Synonyms:exact_synonym: ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate
 related_synonym: Athyromazole;   Carbethoxymethimazole;   Carbimazol;   Carbimazolum;   Carbinazole;   Ethyl 3-methyl-2-thioimidazoline-1-carboxylate;   Formula=C7H10N2O2S;   InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3;   InChIKey=CFOYWRHIYXMDOT-UHFFFAOYSA-N;   SMILES=CCOC(=O)n1ccn(C)c1=S;   Thyrostat
 alt_id: CHEBI:3397
 xref: Beilstein:0144339;   CAS:22232-54-8;   DrugBank:DB00389;   Drug_Central:497;   KEGG:C07615;   KEGG:D07616;   LINCS:LSM-5930
 xref_mesh: MESH:D002231
 xref: PMID:1502708;   PMID:18954039;   PMID:23343442;   PMID:23391946;   PMID:23776913;   PMID:23900475;   PMID:24049063;   PMID:24255992;   PMID:24265129;   PMID:25013255;   Patent:US2671088;   Patent:US2815349;   Reaxys:144339;   VSDB:1876;   Wikipedia:Carbimazole


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carbimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckm creatine kinase, M-type increases expression ISO Carbimazole results in increased expression of CKM protein CTD PMID:2565460 NCBI chr 1:80,321,507...80,331,841
Ensembl chr 1:80,321,585...80,331,841
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pro-agent 8829
          prodrug 8609
            carbimazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  heteroarene 16445
                                    monocyclic heteroarene 13300
                                      azole 12468
                                        diazole 8124
                                          imidazoles 7654
                                            1,3-dihydroimidazole-2-thiones 380
                                              carbimazole 1
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