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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbimazole
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Accession:CHEBI:617099 term browser browse the term
Definition:A member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.
Synonyms:exact_synonym: ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate
 related_synonym: Athyromazole;   Carbethoxymethimazole;   Carbinazole;   Ethyl 3-methyl-2-thioimidazoline-1-carboxylate;   Formula=C7H10N2O2S;   InChI=1S/C7H10N2O2S/c1-3-11-7(10)9-5-4-8(2)6(9)12/h4-5H,3H2,1-2H3;   InChIKey=CFOYWRHIYXMDOT-UHFFFAOYSA-N;   SMILES=CCOC(=O)n1ccn(C)c1=S;   Thyrostat;   carbimazol;   carbimazolum
 alt_id: CHEBI:3397
 xref: Beilstein:0144339;   CAS:22232-54-8;   DrugBank:DB00389;   Drug_Central:497;   KEGG:C07615;   KEGG:D07616;   LINCS:LSM-5930
 xref_mesh: MESH:D002231
 xref: PMID:1502708;   PMID:18954039;   PMID:23343442;   PMID:23391946;   PMID:23776913;   PMID:23900475;   PMID:24049063;   PMID:24255992;   PMID:24265129;   PMID:25013255;   Patent:US2671088;   Patent:US2815349;   Reaxys:144339;   VSDB:1876;   Wikipedia:Carbimazole



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carbimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ckm creatine kinase, M-type increases expression ISO Carbimazole results in increased expression of CKM protein CTD PMID:2565460 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        pro-agent 10113
          prodrug 9917
            carbimazole 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  heteroarene 16539
                                    monocyclic heteroarene 13505
                                      azole 12710
                                        diazole 8600
                                          imidazoles 7695
                                            1,3-dihydroimidazole-2-thiones 382
                                              carbimazole 1
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