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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:epoxy fatty acid
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Accession:CHEBI:61498 term browser browse the term
Definition:A heterocyclic fatty acid containing an epoxide ring as part of its structure.
Synonyms:related_synonym: epoxy fatty acids;   epoxy-FA;   epoxy-FAs;   fatty acid epoxide;   fatty acid epoxides
 xref: PMID:15145985


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14,15-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
increases cleavage
EXP
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form
[14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)
14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
CTD PMID:27428043 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein CTD PMID:16286479 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid CTD PMID:12675279 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions
increases abundance
ISO [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
CTD PMID:19896470, PMID:22680237, PMID:24472606 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein CTD PMID:16286479 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein CTD PMID:19464254 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein CTD PMID:19464254 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:16286479 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion
multiple interactions
ISO TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid
12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:28694203 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx1 epoxide hydrolase 1 affects hydrolysis ISO EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
leukotriene A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase increases chemical synthesis ISO ALOX5 protein results in increased chemical synthesis of Leukotriene A4 CTD PMID:18295198 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303
JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions
increases hydrolysis
ISO cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Leukotriene A4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      molecular entity 19782
        main group molecular entity 19670
          gas molecular entity 17546
            oxirane 5746
              epoxide 5744
                epoxy monocarboxylic acid 24
                  epoxy fatty acid 15
                    (13S)-12,13-epoxyoctadeca-9,11-dienoic acid + 0
                    (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 0
                    (16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoic acid 0
                    (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoic acid 0
                    (4Z,9E,11E,13Z,15E,17S,19Z)-7,8-epoxy-17-hydroxydocosahexaenoic acid 0
                    (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoic acid 0
                    (7R)-hydroxy-(5S,6S)-epoxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                    (9S),10-epoxy-(10,12Z)-octadecadienoic acid 0
                    (9Z,11Z,13S,15Z)-12,13-epoxyoctadecatrienoic acid 0
                    (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoic acid 0
                    11(S)-hydroxy-14(S),15(S)-hepoxilin A3 0
                    11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoic acid 0
                    12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                    14,15-EpETE 0
                    15(16)-EpODE 0
                    17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                    17S,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                    4,5-leukotriene A4 0
                    4S(5)-epoxy-17R-hydroxydocosahexaenoic acid 0
                    5(S),6(S)-epoxy-18(R)-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid 0
                    5(S),6(S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid + 0
                    5(S)6-epoxy-18(S)-HEPE 0
                    7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoic acid 0
                    7S,8S-epoxy-17R-hydroxydocosahexaenoic acid 0
                    9(10)-EpODE 0
                    9,10-epoxy-17-hydroxyoctadecanoic acid 0
                    9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                    9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                    A-12(13)-EpODE 0
                    EET + 12
                    EpETE + 0
                    eoxin A4 0
                    epoxy(hydroxy)icosatrienoic acid + 0
                    epoxydocosapentaenoic acid + 0
                    epoxydocosatetraenoic acid + 0
                    epoxyoctadecenoic acid + 0
                    epoxystearic acid + 0
                    hepoxilin A3 + 0
                    hepoxilin B3 0
                    hydroperoxy(epoxy)icosatrienoic acid + 0
                    juvenile hormone I acid 0
                    juvenile hormone III acid 0
                    leukotriene A4 + 3
                    vernolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        monocarboxylic acid 17406
                                          fatty acid 15844
                                            cyclic fatty acid 511
                                              heterocyclic fatty acid 190
                                                epoxy fatty acid 15
                                                  (13S)-12,13-epoxyoctadeca-9,11-dienoic acid + 0
                                                  (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 0
                                                  (16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoic acid 0
                                                  (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoic acid 0
                                                  (4Z,9E,11E,13Z,15E,17S,19Z)-7,8-epoxy-17-hydroxydocosahexaenoic acid 0
                                                  (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoic acid 0
                                                  (7R)-hydroxy-(5S,6S)-epoxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                                                  (9S),10-epoxy-(10,12Z)-octadecadienoic acid 0
                                                  (9Z,11Z,13S,15Z)-12,13-epoxyoctadecatrienoic acid 0
                                                  (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoic acid 0
                                                  11(S)-hydroxy-14(S),15(S)-hepoxilin A3 0
                                                  11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoic acid 0
                                                  12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                                                  14,15-EpETE 0
                                                  15(16)-EpODE 0
                                                  17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                                                  17S,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                                                  4,5-leukotriene A4 0
                                                  4S(5)-epoxy-17R-hydroxydocosahexaenoic acid 0
                                                  5(S),6(S)-epoxy-18(R)-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid 0
                                                  5(S),6(S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid + 0
                                                  5(S)6-epoxy-18(S)-HEPE 0
                                                  7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoic acid 0
                                                  7S,8S-epoxy-17R-hydroxydocosahexaenoic acid 0
                                                  9(10)-EpODE 0
                                                  9,10-epoxy-17-hydroxyoctadecanoic acid 0
                                                  9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                                                  9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                                                  A-12(13)-EpODE 0
                                                  EET + 12
                                                  EpETE + 0
                                                  eoxin A4 0
                                                  epoxy(hydroxy)icosatrienoic acid + 0
                                                  epoxydocosapentaenoic acid + 0
                                                  epoxydocosatetraenoic acid + 0
                                                  epoxyoctadecenoic acid + 0
                                                  epoxystearic acid + 0
                                                  hepoxilin A3 + 0
                                                  hepoxilin B3 0
                                                  hydroperoxy(epoxy)icosatrienoic acid + 0
                                                  juvenile hormone I acid 0
                                                  juvenile hormone III acid 0
                                                  leukotriene A4 + 3
                                                  vernolic acid + 0
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