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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:epoxy fatty acid
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Accession:CHEBI:61498 term browser browse the term
Definition:A heterocyclic fatty acid containing an epoxide ring as part of its structure.
Synonyms:related_synonym: epoxy fatty acids;   epoxy-FA;   epoxy-FAs;   fatty acid epoxide;   fatty acid epoxides
 xref: PMID:15145985


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14,15-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 decreases activity ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 multiple interactions EXP 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:164,139,342...164,188,418
Ensembl chr  X:164,139,332...164,188,420
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions
decreases expression
increases cleavage
EXP
ISO
14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]
14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form
[14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)
CTD PMID:27428043 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein CTD PMID:16286479 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid CTD PMID:12675279 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases chemical synthesis
multiple interactions
ISO CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases chemical synthesis
multiple interactions
ISO CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases chemical synthesis
multiple interactions
ISO CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic multiple interactions
increases abundance
EXP [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
CTD PMID:19896470, PMID:22680237, PMID:24472606 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein CTD PMID:16286479 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 increases phosphorylation EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein CTD PMID:19464254 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases phosphorylation EXP 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein CTD PMID:19464254 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Ren2 renin 2 tandem duplication of Ren1 multiple interactions EXP 14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]; 14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased transport of 8-epi-prostaglandin F2alpha]; 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased abundance of angiotensin I (1-7)]; 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein]; 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased transport of Nitrogen Oxides] CTD PMID:27428043
G Rps6kb1 ribosomal protein S6 kinase, polypeptide 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:16286479 NCBI chr11:86,498,869...86,544,885
Ensembl chr11:86,498,871...86,544,805
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases secretion
ISO 12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid] CTD PMID:28694203 NCBI chr 7:25,687,002...25,705,077
Ensembl chr 7:25,687,002...25,705,077
JBrowse link
5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 increases chemical synthesis
multiple interactions
ISO CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 5,6-epoxy-8,11,14-eicosatrienoic acid]
CTD PMID:12675279 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic increases abundance EXP EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 increases chemical synthesis
multiple interactions
ISO CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD PMID:12675279 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 increases chemical synthesis
multiple interactions
ISO CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid
Sulfaphenazole inhibits the reaction [CYP2C9 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid]
CTD PMID:12675279 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
increases chemical synthesis
ISO Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 8,9-epoxyeicosatrienoic acid] CTD PMID:12675279 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal affects hydrolysis EXP EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic increases abundance EXP EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
leukotriene A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase increases chemical synthesis ISO ALOX5 protein results in increased chemical synthesis of Leukotriene A4 CTD PMID:18295198 NCBI chr 6:116,410,071...116,461,178
Ensembl chr 6:116,410,077...116,461,178
JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions
increases hydrolysis
ISO cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr10:93,453,396...93,484,896
Ensembl chr10:93,453,411...93,484,875
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity ISO Leukotriene A4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 6:138,140,527...138,156,755
Ensembl chr 6:138,140,316...138,156,755
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21475
    chemical entity 21474
      molecular entity 21457
        main group molecular entity 21360
          gas molecular entity 18704
            oxirane 5747
              epoxide 5745
                epoxy monocarboxylic acid 28
                  epoxy fatty acid 19
                    (13S)-12,13-epoxyoctadeca-9,11-dienoic acid + 0
                    (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 0
                    (16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoic acid 0
                    (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoic acid 0
                    (4Z,9E,11E,13Z,15E,17S,19Z)-7,8-epoxy-17-hydroxydocosahexaenoic acid 0
                    (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoic acid 0
                    (7R)-hydroxy-(5S,6S)-epoxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                    (9S),10-epoxy-(10,12Z)-octadecadienoic acid 0
                    (9Z,11Z,13S,15Z)-12,13-epoxyoctadecatrienoic acid 0
                    (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoic acid 0
                    11(S)-hydroxy-14(S),15(S)-hepoxilin A3 0
                    11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoic acid 0
                    12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                    14,15-EpETE 0
                    15(16)-EpODE 0
                    17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                    17S,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                    4,5-leukotriene A4 0
                    4S(5)-epoxy-17R-hydroxydocosahexaenoic acid 0
                    5(S),6(S)-epoxy-18(R)-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid 0
                    5(S),6(S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid + 0
                    5(S)6-epoxy-18(S)-HEPE 0
                    7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoic acid 0
                    7S,8S-epoxy-17R-hydroxydocosahexaenoic acid 0
                    9(10)-EpODE 0
                    9,10-epoxy-17-hydroxyoctadecanoic acid 0
                    9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                    9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                    A-12(13)-EpODE 0
                    EET + 16
                    EpETE + 0
                    eoxin A4 0
                    epoxy(hydroxy)icosatrienoic acid + 0
                    epoxydocosapentaenoic acid + 0
                    epoxydocosatetraenoic acid + 0
                    epoxyoctadecenoic acid + 0
                    epoxystearic acid + 0
                    hepoxilin A3 + 0
                    hepoxilin B3 0
                    hydroperoxy(epoxy)icosatrienoic acid + 0
                    juvenile hormone I acid 0
                    juvenile hormone III acid 0
                    leukotriene A4 + 3
                    vernolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 21475
    subatomic particle 21460
      composite particle 21460
        hadron 21460
          baryon 21460
            nucleon 21460
              atomic nucleus 21460
                atom 21460
                  main group element atom 21360
                    p-block element atom 21360
                      carbon group element atom 21147
                        carbon atom 21045
                          organic molecular entity 21045
                            organic group 19485
                              organic divalent group 19475
                                organodiyl group 19475
                                  carbonyl group 19452
                                    carbonyl compound 19452
                                      carboxylic acid 19065
                                        monocarboxylic acid 18328
                                          fatty acid 16446
                                            cyclic fatty acid 518
                                              heterocyclic fatty acid 197
                                                epoxy fatty acid 19
                                                  (13S)-12,13-epoxyoctadeca-9,11-dienoic acid + 0
                                                  (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 0
                                                  (16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoic acid 0
                                                  (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoic acid 0
                                                  (4Z,9E,11E,13Z,15E,17S,19Z)-7,8-epoxy-17-hydroxydocosahexaenoic acid 0
                                                  (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoic acid 0
                                                  (7R)-hydroxy-(5S,6S)-epoxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                                                  (9S),10-epoxy-(10,12Z)-octadecadienoic acid 0
                                                  (9Z,11Z,13S,15Z)-12,13-epoxyoctadecatrienoic acid 0
                                                  (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoic acid 0
                                                  11(S)-hydroxy-14(S),15(S)-hepoxilin A3 0
                                                  11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoic acid 0
                                                  12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                                                  14,15-EpETE 0
                                                  15(16)-EpODE 0
                                                  17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                                                  17S,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                                                  4,5-leukotriene A4 0
                                                  4S(5)-epoxy-17R-hydroxydocosahexaenoic acid 0
                                                  5(S),6(S)-epoxy-18(R)-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid 0
                                                  5(S),6(S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid + 0
                                                  5(S)6-epoxy-18(S)-HEPE 0
                                                  7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoic acid 0
                                                  7S,8S-epoxy-17R-hydroxydocosahexaenoic acid 0
                                                  9(10)-EpODE 0
                                                  9,10-epoxy-17-hydroxyoctadecanoic acid 0
                                                  9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                                                  9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                                                  A-12(13)-EpODE 0
                                                  EET + 16
                                                  EpETE + 0
                                                  eoxin A4 0
                                                  epoxy(hydroxy)icosatrienoic acid + 0
                                                  epoxydocosapentaenoic acid + 0
                                                  epoxydocosatetraenoic acid + 0
                                                  epoxyoctadecenoic acid + 0
                                                  epoxystearic acid + 0
                                                  hepoxilin A3 + 0
                                                  hepoxilin B3 0
                                                  hydroperoxy(epoxy)icosatrienoic acid + 0
                                                  juvenile hormone I acid 0
                                                  juvenile hormone III acid 0
                                                  leukotriene A4 + 3
                                                  vernolic acid + 0
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