Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:epoxy fatty acid
go back to main search page
Accession:CHEBI:61498 term browser browse the term
Definition:A heterocyclic fatty acid containing an epoxide ring as part of its structure.
Synonyms:related_synonym: epoxy fatty acids;   epoxy-FA;   epoxy-FAs;   fatty acid epoxide;   fatty acid epoxides
 xref: PMID:15145985

show annotations for term's descendants           Sort by:
 
14,15-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased activity of ACE protein CTD PMID:27428043 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822 		JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions ISO 14,15-epoxy-5,8,11-eicosatrienoic acid analog promotes the reaction [REN2 protein results in increased expression of ACE2 protein] CTD PMID:27428043 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016 		JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
increases cleavage		 EXP
ISO		 14,15-epoxy-5,8,11-eicosatrienoic acid analog results in decreased expression of AGT protein modified form
[14,15-epoxy-5,8,11-eicosatrienoic acid analog results in increased cleavage of AGT protein modified form] which results in increased abundance of angiotensin I (1-7)
14,15-epoxy-5,8,11-eicosatrienoic acid analog inhibits the reaction [REN2 protein results in increased expression of AGT protein modified form]		 CTD PMID:27428043 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of AKT1 protein CTD PMID:16286479 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of 14,15-epoxy-5,8,11-eicosatrienoic acid CTD PMID:12675279 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Ephx2 epoxide hydrolase 2 multiple interactions
increases abundance		 ISO [Arsenites results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid; [Mercuric Chloride results in increased expression of and results in increased activity of EPHX2 protein] which results in decreased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid
EPHX2 gene mutant form results in increased abundance of 14,15-epoxy-5,8,11-eicosatrienoic acid		 CTD PMID:19896470, PMID:22680237, PMID:24472606 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279 		JBrowse link
G Fgf2 fibroblast growth factor 2 increases expression ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased expression of FGF2 protein CTD PMID:16286479 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK1 protein CTD PMID:19464254 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of MAPK3 protein CTD PMID:19464254 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation ISO 14,15-epoxy-5,8,11-eicosatrienoic acid results in increased phosphorylation of RPS6KB1 protein CTD PMID:16286479 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion
multiple interactions		 ISO TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid
12-(3-adamantan-1-ylureido)dodecanoic acid inhibits the reaction [TGFB1 protein results in decreased secretion of 14,15-epoxy-5,8,11-eicosatrienoic acid]		 CTD PMID:28694203 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
5,6-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 5,6-epoxy-8,11,14-eicosatrienoic acid CTD PMID:19896470 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279 		JBrowse link
8,9-EET term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ephx1 epoxide hydrolase 1 affects hydrolysis ISO EPHX1 protein affects the hydrolysis of 8,9-epoxyeicosatrienoic acid CTD PMID:28975360 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579 		JBrowse link
G Ephx2 epoxide hydrolase 2 increases abundance ISO EPHX2 gene mutant form results in increased abundance of 8,9-epoxyeicosatrienoic acid CTD PMID:19896470 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279 		JBrowse link
leukotriene A4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox5 arachidonate 5-lipoxygenase increases chemical synthesis ISO ALOX5 protein results in increased chemical synthesis of Leukotriene A4 CTD PMID:18295198 NCBI chr 4:148,398,004...148,446,308
Ensembl chr 4:148,398,892...148,446,303 		JBrowse link
G Lta4h leukotriene A4 hydrolase multiple interactions
increases hydrolysis		 ISO cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Oxygen inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; Piperonyl Butoxide inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]; propanethiol inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr 7:34,288,333...34,320,243
Ensembl chr 7:34,288,365...34,320,235 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 decreases activity EXP Leukotriene A4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    chemical entity 19791
      molecular entity 19787
        main group molecular entity 19675
          gas molecular entity 17570
            oxirane 5738
              epoxide 5736
                epoxy monocarboxylic acid 22
                  epoxy fatty acid 15
                    (13S)-12,13-epoxyoctadeca-9,11-dienoic acid + 0
                    (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 0
                    (16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoic acid 0
                    (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoic acid 0
                    (4Z,9E,11E,13Z,15E,17S,19Z)-7,8-epoxy-17-hydroxydocosahexaenoic acid 0
                    (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoic acid 0
                    (7R)-hydroxy-(5S,6S)-epoxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                    (9S),10-epoxy-(10,12Z)-octadecadienoic acid 0
                    (9Z,11Z,13S,15Z)-12,13-epoxyoctadecatrienoic acid 0
                    (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoic acid 0
                    11(S)-hydroxy-14(S),15(S)-hepoxilin A3 0
                    11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoic acid 0
                    12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                    14,15-EpETE 0
                    15(16)-EpODE 0
                    17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                    17S,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                    4,5-leukotriene A4 0
                    4S(5)-epoxy-17R-hydroxydocosahexaenoic acid 0
                    5(S),6(S)-epoxy-18(R)-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid 0
                    5(S),6(S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid + 0
                    5(S)6-epoxy-18(S)-HEPE 0
                    7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoic acid 0
                    7S,8S-epoxy-17R-hydroxydocosahexaenoic acid 0
                    9(10)-EpODE 0
                    9,10-epoxy-17-hydroxyoctadecanoic acid 0
                    9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                    9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                    A-12(13)-EpODE 0
                    EET + 12
                    EpETE + 0
                    eoxin A4 0
                    epoxy(hydroxy)icosatrienoic acid + 0
                    epoxydocosapentaenoic acid + 0
                    epoxydocosatetraenoic acid + 0
                    epoxyoctadecenoic acid + 0
                    epoxystearic acid + 0
                    hepoxilin A3 + 0
                    hepoxilin B3 0
                    hydroperoxy(epoxy)icosatrienoic acid + 0
                    juvenile hormone I acid 0
                    juvenile hormone III acid 0
                    leukotriene A4 + 3
                    vernolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      carboxylic acid 18079
                                        monocarboxylic acid 17425
                                          fatty acid 15860
                                            cyclic fatty acid 505
                                              heterocyclic fatty acid 182
                                                epoxy fatty acid 15
                                                  (13S)-12,13-epoxyoctadeca-9,11-dienoic acid + 0
                                                  (13S,14S)-epoxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoic acid 0
                                                  (16S,17S)-epoxy-(4Z,7Z,10Z,12E,14E,19Z)-docosahexaenoic acid 0
                                                  (2E,6E,10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoic acid 0
                                                  (4Z,9E,11E,13Z,15E,17S,19Z)-7,8-epoxy-17-hydroxydocosahexaenoic acid 0
                                                  (5Z,9E,14Z)-(8xi,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoic acid 0
                                                  (7R)-hydroxy-(5S,6S)-epoxy-(8Z,11Z,14Z)-icosatrienoic acid 0
                                                  (9S),10-epoxy-(10,12Z)-octadecadienoic acid 0
                                                  (9Z,11Z,13S,15Z)-12,13-epoxyoctadecatrienoic acid 0
                                                  (9Z,13S,15Z)-12,13-epoxyoctadeca-9,11,15-trienoic acid 0
                                                  11(S)-hydroxy-14(S),15(S)-hepoxilin A3 0
                                                  11-hydroxy-(12S,13S)-epoxy-(9Z)-octadecenoic acid 0
                                                  12,13-epoxy-18-hydroxy-(9Z)-octadecenoic acid 0
                                                  14,15-EpETE 0
                                                  15(16)-EpODE 0
                                                  17R,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                                                  17S,(16)-epoxy-(4Z,7Z,10Z,13Z,19Z)-docosahexa-4,7,10,13,15,19-enoic acid 0
                                                  4,5-leukotriene A4 0
                                                  4S(5)-epoxy-17R-hydroxydocosahexaenoic acid 0
                                                  5(S),6(S)-epoxy-18(R)-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid 0
                                                  5(S),6(S)-epoxy-18-hydroxy-(7E,9E,11Z,14Z,16E)-icosapentaenoic acid + 0
                                                  5(S)6-epoxy-18(S)-HEPE 0
                                                  7,8-epoxy,17-hydroxy-(9E,11E,13Z,15E,19Z)-docosapentaenoic acid 0
                                                  7S,8S-epoxy-17R-hydroxydocosahexaenoic acid 0
                                                  9(10)-EpODE 0
                                                  9,10-epoxy-17-hydroxyoctadecanoic acid 0
                                                  9,10-epoxy-18-hydroxy-(12Z)-octadecenoic acid 0
                                                  9,10-epoxy-18-hydroxyoctadecanoic acid + 0
                                                  A-12(13)-EpODE 0
                                                  EET + 12
                                                  EpETE + 0
                                                  eoxin A4 0
                                                  epoxy(hydroxy)icosatrienoic acid + 0
                                                  epoxydocosapentaenoic acid + 0
                                                  epoxydocosatetraenoic acid + 0
                                                  epoxyoctadecenoic acid + 0
                                                  epoxystearic acid + 0
                                                  hepoxilin A3 + 0
                                                  hepoxilin B3 0
                                                  hydroperoxy(epoxy)icosatrienoic acid + 0
                                                  juvenile hormone I acid 0
                                                  juvenile hormone III acid 0
                                                  leukotriene A4 + 3
                                                  vernolic acid + 0
paths to the root

Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.