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ONTOLOGY REPORT - ANNOTATIONS


Term:canertinib
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Accession:CHEBI:61399 term browser browse the term
Definition:A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a propenamido group at the 6-position, and a 3-morpholinopropoxy group at the 7-position.
Synonyms:exact_synonym: N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide
 related_synonym: CI-1033;   Formula=C24H25ClFN5O3;   InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29);   InChIKey=OMZCMEYTWSXEPZ-UHFFFAOYSA-N;   SMILES=Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
 xref: CAS:267243-28-7 "ChemIDplus";   LINCS:LSM-1120
 xref_mesh: MESH:C420268
 xref: PMID:11706399 "Europe PMC";   PMID:15534081 "Europe PMC"


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canertinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Cdk4 cyclin-dependent kinase 4 JBrowse link 7 70,345,971 70,352,689 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Endog endonuclease G JBrowse link 3 8,741,833 8,744,414 RGD:6480464
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

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Term Annotations click to browse term
  CHEBI ontology 19614
    role 19557
      application 19155
        pharmaceutical 19058
          drug 19058
            antineoplastic agent 16543
              canertinib 11
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Term Annotations click to browse term
  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    p-block element atom 19489
                      carbon group element atom 19362
                        carbon atom 19354
                          organic molecular entity 19354
                            organic molecule 19272
                              organic cyclic compound 19061
                                carbocyclic compound 17475
                                  benzenoid aromatic compound 16965
                                    benzenes 16649
                                      chlorobenzenes 12529
                                        monochlorobenzenes 8728
                                          canertinib 11
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.