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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ketorolac tromethamine
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Accession:CHEBI:6130 term browser browse the term
Definition:An organoammonium salt resulting from the mixture of equimolar amounts of ketorolac and tromethamine (tris). It has potent non-sedating analgesic and moderate anti-inflammatory effects. It is used in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis.
Synonyms:exact_synonym: 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate
 related_synonym: Acular;   Acuvail;   Dolac;   Formula=C19H24N2O6;   InChI=1S/C15H13NO3.C4H11NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13;5-4(1-6,2-7)3-8/h1-7,11H,8-9H2,(H,18,19);6-8H,1-3,5H2;   InChIKey=BWHLPLXXIDYSNW-UHFFFAOYSA-N;   Lixidol;   SMILES=[NH3+]C(CO)(CO)CO.[O-]C(=O)C1CCn2c1ccc2C(=O)c1ccccc1;   Sprix;   Toradol
 xref: CAS:74103-07-4;   DrugBank:DB00465;   HMDB:HMDB0014608;   KEGG:D00813
 xref_mesh: MESH:D020911
 xref: PMID:19663721;   PMID:23016110;   PMID:23098098;   PMID:23199134;   PMID:23302965;   PMID:23992042;   PMID:8863973;   Reaxys:6463165

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ketorolac tromethamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ereg epiregulin increases expression ISO Ketorolac Tromethamine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394 		JBrowse link
G Il24 interleukin 24 increases expression ISO Ketorolac Tromethamine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Ketorolac Tromethamine results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Ketorolac Tromethamine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      biological role 19726
        pharmacological role 18834
          analgesic 13094
            ketorolac tromethamine 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    main group molecular entity 19669
                      s-block molecular entity 19434
                        hydrogen molecular entity 19429
                          hydrides 18757
                            inorganic hydride 17455
                              pnictogen hydride 17431
                                nitrogen hydride 17278
                                  ammonium 8223
                                    ammonium ion derivative 8219
                                      ammonium compound 5079
                                        organoammonium salt 424
                                          ketorolac tromethamine 4
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