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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ketorolac
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Accession:CHEBI:6129 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
Synonyms:exact_synonym: rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
 related_synonym: (+-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;   Formula=C15H13NO3;   InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19);   InChIKey=OZWKMVRBQXNZKK-UHFFFAOYSA-N;   SMILES=N12C(C(C(=O)O)CC1)=CC=C2C(=O)C3=CC=CC=C3;   ketorolaco;   ketorolacum;   rac-ketorolac
 xref: CAS:74103-06-3;   DrugBank:DB00465;   HMDB:HMDB0014608;   KEGG:C07062;   KEGG:D08104
 xref_mesh: MESH:D020910
 xref: PMID:10027870;   PMID:10223774;   PMID:10593468;   PMID:17456651;   PMID:19281996;   PMID:22191998;   PMID:23088994;   PMID:23126437;   PMID:23179562;   PMID:23298250;   PMID:23447046;   PMID:23473380;   PMID:23562034;   PMID:23653032;   PMID:23702435;   PMID:24022643;   PMID:24112670;   PMID:28166217;   PMID:9549656;   Patent:BE856681;   Patent:US4089969;   Patent:US4347186;   Reaxys:413572;   Wikipedia:Ketorolac
 cyclic_relationship: is_conjugate_acid_of CHEBI:76229

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ketorolac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G R Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Ketorolac results in decreased expression of CXCL1 mRNA CTD PMID:19620882 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G M Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Ketorolac results in decreased expression of CXCL1 mRNA CTD PMID:19620882 NCBI chr 5:91,039,104...91,040,980
Ensembl chr 5:91,039,100...91,040,974 		JBrowse link
G H CXCL1 C-X-C motif chemokine ligand 1 decreases expression ISO Ketorolac results in decreased expression of CXCL1 mRNA CTD PMID:19620882 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G R Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions ISO Ketorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA] CTD PMID:19767084 NCBI chr  X:71,661,421...71,690,012
Ensembl chr  X:71,663,821...71,690,121 		JBrowse link
G M Cysltr1 cysteinyl leukotriene receptor 1 multiple interactions ISO Ketorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA] CTD PMID:19767084 NCBI chr  X:105,617,952...105,647,329
Ensembl chr  X:105,617,952...105,647,285 		JBrowse link
G H CYSLTR1 cysteinyl leukotriene receptor 1 multiple interactions EXP Ketorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA] CTD PMID:19767084 NCBI chr  X:78,271,468...78,327,611
Ensembl chr  X:78,271,468...78,327,691 		JBrowse link
G R Ddx3x DEAD-box helicase 3, X-linked decreases expression ISO ketorolac decreases expression of DDX3X protein in oral epithelium RGD PMID:25918862 RGD:151356506 NCBI chr  X:9,479,532...9,493,169
Ensembl chr  X:9,479,532...9,493,168 		JBrowse link
G M Ddx3x DEAD box helicase 3, X-linked decreases expression ISO ketorolac decreases expression of DDX3X protein in oral epithelium RGD PMID:25918862 RGD:151356506 NCBI chr  X:13,147,261...13,160,222
Ensembl chr  X:13,147,209...13,160,291 		JBrowse link
G H DDX3X DEAD-box helicase 3 X-linked decreases expression EXP ketorolac decreases expression of DDX3X protein in oral epithelium RGD PMID:25918862 RGD:151356506 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472 		JBrowse link
G R Epas1 endothelial PAS domain protein 1 decreases expression ISO Ketorolac results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228 		JBrowse link
G M Epas1 endothelial PAS domain protein 1 decreases expression ISO Ketorolac results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr17:87,061,292...87,140,838
Ensembl chr17:87,061,128...87,140,838 		JBrowse link
G H EPAS1 endothelial PAS domain protein 1 decreases expression EXP Ketorolac results in decreased expression of EPAS1 protein CTD PMID:12912967 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697 		JBrowse link
G R Fcer1a Fc epsilon receptor Ia multiple interactions ISO Ketorolac inhibits the reaction [IL4 results in increased expression of FCER1A mRNA] CTD PMID:19767084 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351 		JBrowse link
G M Fcer1a Fc receptor, IgE, high affinity I, alpha polypeptide multiple interactions ISO Ketorolac inhibits the reaction [IL4 results in increased expression of FCER1A mRNA] CTD PMID:19767084 NCBI chr 1:173,048,836...173,054,799
Ensembl chr 1:173,048,851...173,054,781 		JBrowse link
G H FCER1A Fc epsilon receptor Ia multiple interactions EXP Ketorolac inhibits the reaction [IL4 results in increased expression of FCER1A mRNA] CTD PMID:19767084 NCBI chr 1:159,283,575...159,308,202
Ensembl chr 1:159,289,714...159,308,224 		JBrowse link
G R Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ketorolac inhibits the reaction [IL1B protein results in increased expression of FOS mRNA] CTD PMID:10800959 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G M Fos FBJ osteosarcoma oncogene multiple interactions ISO Ketorolac inhibits the reaction [IL1B protein results in increased expression of FOS mRNA] CTD PMID:10800959 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G H FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Ketorolac inhibits the reaction [IL1B protein results in increased expression of FOS mRNA] CTD PMID:10800959 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G M H2-M3 histocompatibility 2, M region locus 3 affects expression ISO Ketorolac affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr17:37,581,094...37,585,380
Ensembl chr17:37,581,111...37,585,375 		JBrowse link
G M H2-Q1 histocompatibility 2, Q region locus 1 affects expression ISO Ketorolac affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr17:35,539,503...35,547,118
Ensembl chr17:35,539,381...35,544,075 		JBrowse link
G M H2-T23 histocompatibility 2, T region locus 23 affects expression ISO Ketorolac affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr17:36,340,869...36,343,593
Ensembl chr17:36,340,665...36,343,747 		JBrowse link
G R Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Ketorolac results in decreased expression of HIF1A protein CTD PMID:12912967 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G M Hif1a hypoxia inducible factor 1, alpha subunit decreases expression ISO Ketorolac results in decreased expression of HIF1A protein CTD PMID:12912967 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G H HIF1A hypoxia inducible factor 1 subunit alpha decreases expression EXP Ketorolac results in decreased expression of HIF1A protein CTD PMID:12912967 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G H HLA-A major histocompatibility complex, class I, A affects expression EXP Ketorolac affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr 6:29,942,532...29,945,870
Ensembl chr 6:29,941,260...29,949,572 		JBrowse link
G H HLA-E major histocompatibility complex, class I, E affects expression EXP Ketorolac affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194 		JBrowse link
G H HLA-G major histocompatibility complex, class I, G affects expression EXP Ketorolac affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr 6:29,826,474...29,831,021
Ensembl chr 6:29,826,967...29,831,125 		JBrowse link
G R Icam1 intercellular adhesion molecule 1 decreases expression EXP Ketorolac results in decreased expression of ICAM1 mRNA CTD PMID:19620882 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G M Icam1 intercellular adhesion molecule 1 decreases expression ISO Ketorolac results in decreased expression of ICAM1 mRNA CTD PMID:19620882 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G H ICAM1 intercellular adhesion molecule 1 decreases expression ISO Ketorolac results in decreased expression of ICAM1 mRNA CTD PMID:19620882 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G R Il1b interleukin 1 beta multiple interactions EXP [Ketorolac co-treated with IL1B protein] results in increased secretion of Dinoprostone; Ketorolac inhibits the reaction [IL1B protein results in increased expression of FOS mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased expression of NR4A1 mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased secretion of Corticosterone] CTD PMID:10800959 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G M Il1b interleukin 1 beta multiple interactions ISO [Ketorolac co-treated with IL1B protein] results in increased secretion of Dinoprostone; Ketorolac inhibits the reaction [IL1B protein results in increased expression of FOS mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased expression of NR4A1 mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased secretion of Corticosterone] CTD PMID:10800959 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G H IL1B interleukin 1 beta multiple interactions ISO [Ketorolac co-treated with IL1B protein] results in increased secretion of Dinoprostone; Ketorolac inhibits the reaction [IL1B protein results in increased expression of FOS mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased expression of NR4A1 mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA]; Ketorolac inhibits the reaction [IL1B protein results in increased secretion of Corticosterone] CTD PMID:10800959 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G R Il4 interleukin 4 multiple interactions ISO Ketorolac inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Ketorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]; Ketorolac inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]; Ketorolac inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G M Il4 interleukin 4 multiple interactions ISO Ketorolac inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Ketorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]; Ketorolac inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]; Ketorolac inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G H IL4 interleukin 4 multiple interactions EXP Ketorolac inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Ketorolac inhibits the reaction [IL4 results in increased expression of CYSLTR1 mRNA]; Ketorolac inhibits the reaction [IL4 results in increased expression of FCER1A mRNA]; Ketorolac inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G R Mpo myeloperoxidase decreases activity EXP Ketorolac results in decreased activity of MPO CTD PMID:11996850 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G M Mpo myeloperoxidase decreases activity ISO Ketorolac results in decreased activity of MPO CTD PMID:11996850 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G H MPO myeloperoxidase decreases activity ISO Ketorolac results in decreased activity of MPO CTD PMID:11996850 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G R Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP Ketorolac inhibits the reaction [IL1B protein results in increased expression of NR4A1 mRNA] CTD PMID:10800959 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G M Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO Ketorolac inhibits the reaction [IL1B protein results in increased expression of NR4A1 mRNA] CTD PMID:10800959 NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676 		JBrowse link
G H NR4A1 nuclear receptor subfamily 4 group A member 1 multiple interactions ISO Ketorolac inhibits the reaction [IL1B protein results in increased expression of NR4A1 mRNA] CTD PMID:10800959 NCBI chr12:52,022,832...52,059,503
Ensembl chr12:52,022,832...52,059,507 		JBrowse link
G R Ptger4 prostaglandin E receptor 4 multiple interactions EXP Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA] CTD PMID:10800959 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670 		JBrowse link
G M Ptger4 prostaglandin E receptor 4 (subtype EP4) multiple interactions ISO Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA] CTD PMID:10800959 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668 		JBrowse link
G H PTGER4 prostaglandin E receptor 4 multiple interactions ISO Ketorolac inhibits the reaction [IL1B protein results in increased expression of PTGER4 mRNA] CTD PMID:10800959 NCBI chr 5:40,679,915...40,746,800
Ensembl chr 5:40,679,915...40,693,735 		JBrowse link
G R Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
decreases activity		 ISO Ketorolac results in decreased expression of PTGS1 mRNA
Ketorolac results in decreased activity of PTGS1 protein		 CTD PMID:17175104 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G M Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
decreases activity		 ISO Ketorolac results in decreased expression of PTGS1 mRNA
Ketorolac results in decreased activity of PTGS1 protein		 CTD PMID:17175104 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G H PTGS1 prostaglandin-endoperoxide synthase 1 decreases expression
decreases activity		 EXP Ketorolac results in decreased expression of PTGS1 mRNA
Ketorolac results in decreased activity of PTGS1 protein		 CTD PMID:17175104 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G R Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
decreases expression		 ISO
EXP		 Ketorolac results in increased expression of PTGS2 mRNA
Ketorolac inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Carrageenan results in increased expression of PTGS2 protein]]
Ketorolac results in decreased expression of PTGS2 mRNA		 CTD PMID:17175104 PMID:17258197 PMID:19620882 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G M Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
decreases expression		 ISO Ketorolac results in increased expression of PTGS2 mRNA
Ketorolac inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Carrageenan results in increased expression of PTGS2 protein]]
Ketorolac results in decreased expression of PTGS2 mRNA		 CTD PMID:17175104 PMID:17258197 PMID:19620882 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G H PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
decreases expression		 EXP
ISO		 Ketorolac results in increased expression of PTGS2 mRNA
Ketorolac inhibits the reaction [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide promotes the reaction [Carrageenan results in increased expression of PTGS2 protein]]
Ketorolac results in decreased expression of PTGS2 mRNA		 CTD PMID:17175104 PMID:17258197 PMID:19620882 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G R RT1-A2 RT1 class Ia, locus A2 affects expression ISO Ketorolac affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G R RT1-CE16 RT1 class I, locus CE16 affects expression ISO Ketorolac affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563 		JBrowse link
G R RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Ketorolac affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G R Sele selectin E decreases expression EXP Ketorolac results in decreased expression of SELE mRNA CTD PMID:19620882 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G M Sele selectin, endothelial cell decreases expression ISO Ketorolac results in decreased expression of SELE mRNA CTD PMID:19620882 NCBI chr 1:163,867,200...163,886,056
Ensembl chr 1:163,875,773...163,885,246 		JBrowse link
G H SELE selectin E decreases expression ISO Ketorolac results in decreased expression of SELE mRNA CTD PMID:19620882 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705 		JBrowse link
G R Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Ketorolac inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Ketorolac inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G M Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Ketorolac inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Ketorolac inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr10:127,478,855...127,496,856
Ensembl chr10:127,478,855...127,496,826 		JBrowse link
G H STAT6 signal transducer and activator of transcription 6 multiple interactions EXP Ketorolac inhibits the reaction [IL4 results in increased activity of STAT6 protein]; Ketorolac inhibits the reaction [IL4 results in increased phosphorylation of STAT6 protein] CTD PMID:19767084 NCBI chr12:57,095,408...57,111,362
Ensembl chr12:57,095,408...57,132,139 		JBrowse link
G M Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO Ketorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796 		JBrowse link
G R Ugt2b7 UDP glucuronosyltransferase family 2 member B7 multiple interactions ISO Ketorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604 		JBrowse link
G H UGT2B7 UDP glucuronosyltransferase family 2 member B7 multiple interactions EXP Ketorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased glucuronidation of Aldosterone] CTD PMID:19740398 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 73571
    role 73520
      biological role 73388
        pharmacological role 61645
          analgesic 45189
            ketorolac 63
Path 2
Term Annotations click to browse term
  CHEBI ontology 73571
    subatomic particle 73527
      composite particle 73527
        hadron 73635
          baryon 73527
            nucleon 73527
              atomic nucleus 73527
                atom 73527
                  main group element atom 73199
                    main group molecular entity 73198
                      s-block molecular entity 71932
                        hydrogen molecular entity 71427
                          hydrides 67717
                            inorganic hydride 57977
                              pnictogen hydride 57882
                                nitrogen hydride 57432
                                  azane 56877
                                    ammonia 56874
                                      organic amino compound 56767
                                        amino acid 49765
                                          5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid 63
                                            (S)-ketorolac 63
                                              ketorolac 63
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