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ONTOLOGY REPORT - ANNOTATIONS


Term:ketorolac
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Accession:CHEBI:6129 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure.
Synonyms:exact_synonym: rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
 related_synonym: (+-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid;   Formula=C15H13NO3;   InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19);   InChIKey=OZWKMVRBQXNZKK-UHFFFAOYSA-N;   SMILES=N12C(C(C(=O)O)CC1)=CC=C2C(=O)C3=CC=CC=C3;   ketorolaco;   ketorolacum;   rac-ketorolac
 xref: CAS:74103-06-3 "ChemIDplus";   CAS:74103-06-3 "KEGG COMPOUND";   CAS:74103-06-3 "KEGG DRUG";   DrugBank:DB00465;   HMDB:HMDB0014608;   KEGG:C07062;   KEGG:D08104
 xref_mesh: MESH:D020910
 xref: PMID:10027870 "Europe PMC";   PMID:10223774 "Europe PMC";   PMID:10593468 "Europe PMC";   PMID:17456651 "Europe PMC";   PMID:19281996 "Europe PMC";   PMID:22191998 "Europe PMC";   PMID:23088994 "Europe PMC";   PMID:23126437 "Europe PMC";   PMID:23179562 "Europe PMC";   PMID:23298250 "Europe PMC";   PMID:23447046 "Europe PMC";   PMID:23473380 "Europe PMC";   PMID:23562034 "Europe PMC";   PMID:23653032 "Europe PMC";   PMID:23702435 "Europe PMC";   PMID:24022643 "Europe PMC";   PMID:24112670 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:9549656 "Europe PMC";   Patent:BE856681;   Patent:US4089969;   Patent:US4347186;   Reaxys:413572 "Reaxys";   Wikipedia:Ketorolac
 cyclic_relationship: is_conjugate_acid_of CHEBI:76229


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ketorolac term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Cysltr1 cysteinyl leukotriene receptor 1 JBrowse link X 77,671,028 77,700,491 RGD:6480464
G Epas1 endothelial PAS domain protein 1 JBrowse link 6 10,306,508 10,385,239 RGD:6480464
G Fcer1a Fc fragment of IgE receptor Ia JBrowse link 13 91,727,253 91,737,106 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:6480464
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:6480464
G LOC100364500 RT1 class I, locus CE11-like JBrowse link 20 2,704,153 2,707,111 RGD:6480464
G Mpo myeloperoxidase JBrowse link 10 75,087,892 75,098,260 RGD:6480464
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 JBrowse link 7 142,899,358 142,920,216 RGD:6480464
G Ptger4 prostaglandin E receptor 4 JBrowse link 2 54,951,625 54,966,470 RGD:6480464
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G RT1-S3 RT1 class Ib, locus S3 JBrowse link 20 3,176,124 3,180,825 RGD:6480464
G Sele selectin E JBrowse link 13 82,355,234 82,365,323 RGD:6480464
G Stat6 signal transducer and activator of transcription 6 JBrowse link 7 70,946,228 70,963,542 RGD:6480464
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 JBrowse link 14 22,597,103 22,619,968 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          analgesic 13037
            ketorolac 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid 19
                                            (R)-ketorolac 19
                                              ketorolac 19
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