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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:scutellarin
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Accession:CHEBI:61278 term browser browse the term
Definition:The glycosyloxyflavone which is the 7-O-glucuronide of scutellarein.
Synonyms:exact_synonym: 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranosiduronic acid
 related_synonym: Formula=C21H18O12;   InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1;   InChIKey=DJSISFGPUUYILV-ZFORQUDYSA-N;   SMILES=O[C@H]1[C@@H](O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O)Oc1cc2oc(cc(=O)c2c(O)c1O)-c1ccc(O)cc1;   Scutellarein 7-O-beta-D-glucuronide;   Scutellarein-7-glucuronide;   Scutellarein-7beta-D-glucuronide;   Scutellarein-7beta-D-glucuronoside
 xref: CAS:27740-01-8
 xref_mesh: MESH:C484876
 xref: PMID:10724177;   PMID:22092277;   PMID:23147714;   PMID:23177255;   PMID:23192830;   Reaxys:71779;   Wikipedia:Scutellarin
 cyclic_relationship: is_conjugate_acid_of CHEBI:61284



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scutellarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO scutellarin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO scutellarin inhibits the reaction [cobaltous chloride results in decreased expression of BCL2L1 mRNA] CTD PMID:18442013 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648
JBrowse link
G Casp1 caspase 1 multiple interactions ISO scutellarin inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA] CTD PMID:37081038 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
scutellarin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]
scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]
CTD PMID:18442013 PMID:36252740 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO scutellarin results in decreased expression of FGF2 protein CTD PMID:16297343 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257
JBrowse link
G Gsdmd gasdermin D multiple interactions ISO scutellarin inhibits the reaction [Streptozocin results in increased expression of GSDMD protein] CTD PMID:37081038 NCBI chr15:75,733,990...75,739,257
Ensembl chr15:75,734,176...75,739,257
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
decreases expression
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; MG 262 inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]] CTD PMID:25192544 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Il18 interleukin 18 multiple interactions ISO scutellarin inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:37081038 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140
JBrowse link
G Jun jun proto-oncogene multiple interactions EXP scutellarin inhibits the reaction [Zearalenone results in increased expression of JUN protein] CTD PMID:36252740 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459
JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 multiple interactions EXP scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] CTD PMID:36252740 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123
JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein] CTD PMID:25192544 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO scutellarin inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein] CTD PMID:37081038 NCBI chr11:59,432,395...59,457,781
Ensembl chr11:59,432,394...59,457,782
JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases expression ISO scutellarin results in decreased expression of NOS2 protein CTD PMID:16297343 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080
JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell increases expression ISO scutellarin results in increased expression of NOS3 protein CTD PMID:16297343 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA protein] CTD PMID:25192544 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234
JBrowse link
G Pkm pyruvate kinase, muscle increases activity ISO scutellarin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 9:59,563,859...59,586,655
Ensembl chr 9:59,563,651...59,586,658
JBrowse link
G Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) affects activity ISO scutellarin affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 4:138,559,168...138,562,500
Ensembl chr 4:138,559,171...138,562,497
JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 multiple interactions EXP scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 mRNA]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 protein] CTD PMID:36252740 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO scutellarin results in decreased expression of VEGFA protein
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein]
CTD PMID:16297343 PMID:25192544 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link

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  CHEBI ontology 22194
    role 22179
      application 21760
        pharmaceutical 21174
          drug 21174
            antineoplastic agent 18895
              scutellarin 20
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  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            organic molecule 21662
                              organic cyclic compound 21269
                                organic heterocyclic compound 20342
                                  oxacycle 18841
                                    benzopyran 12214
                                      1-benzopyran 11971
                                        flavonoid 7262
                                          anthoxanthin 4591
                                            flavones 4591
                                              hydroxyflavone 4568
                                                trihydroxyflavone 429
                                                  apigenin 293
                                                    scutellarein 46
                                                      scutellarin 20
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