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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ketanserin
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Accession:CHEBI:6123 term browser browse the term
Definition:A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Synonyms:exact_synonym: 3-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}quinazoline-2,4(1H,3H)-dione
 related_synonym: 3-[2-[4-(4-fluorobenzoyl)-1-piperidyl]ethyl]-1H-quinazoline-2,4-dione;   Formula=C22H22FN3O3;   InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29);   InChIKey=FPCCSQOGAWCVBH-UHFFFAOYSA-N;   SMILES=Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2ccccc2c1=O;   ketanserina;   ketanserine;   ketanserinum
 xref: Beilstein:4913068;   CAS:74050-98-9;   Drug_Central:1524;   KEGG:C07464;   KEGG:D02363;   LINCS:LSM-3092
 xref_mesh: MESH:D007650
 xref: PMID:11110040;   PMID:18574455;   PMID:18950618;   PMID:19058975;   PMID:20825390;   PMID:22091605;   PMID:2678304;   PMID:8583787;   Patent:EP13612;   Patent:US4335127;   Reaxys:4913068;   Wikipedia:Ketanserin


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ketanserin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A multiple interactions ISO
EXP
Ketanserin inhibits the reaction [Prazosin binds to ADRA1A protein]
Ketanserin binds to and results in decreased activity of ADRA1A protein
CTD PMID:11937776 PMID:16545797 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO Ketanserin inhibits the reaction [Prazosin binds to ADRA1B protein] CTD PMID:11937776 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions ISO Ketanserin inhibits the reaction [Prazosin binds to ADRA1D protein] CTD PMID:11937776 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]; Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein] CTD PMID:22975078 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP [Fluoxetine co-treated with Ketanserin] results in increased expression of BDNF mRNA CTD PMID:21627639 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP [Fluoxetine co-treated with Ketanserin] results in increased expression of CTNNB1 mRNA CTD PMID:21627639 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ddc dopa decarboxylase increases activity ISO Ketanserin results in increased activity of DDC protein CTD PMID:16415089 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
decreases activity
affects binding
ISO
EXP
Aripiprazole inhibits the reaction [Ketanserin binds to HTR2A protein]; Clozapine inhibits the reaction [Ketanserin binds to HTR2A protein]; Ketanserin binds to and results in decreased activity of HTR2A protein; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [Ketanserin binds to HTR2A protein]; Quetiapine Fumarate inhibits the reaction [Ketanserin binds to HTR2A protein]; Spiperone inhibits the reaction [Ketanserin binds to HTR2A protein]; ziprasidone inhibits the reaction [Ketanserin binds to HTR2A protein]
Ketanserin results in decreased activity of HTR2A protein
8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [Ketanserin binds to HTR2A protein]; [Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in decreased abundance of Serotonin]; [Ketanserin binds to and results in decreased activity of HTR2A protein] inhibits the reaction [Methamphetamine results in increased secretion of Corticosterone]; [Ketanserin binds to and results in decreased activity of HTR2A protein] which results in decreased susceptibility to Serotonin; Diazinon promotes the reaction [Ketanserin binds to HTR2A protein]; Ketanserin binds to and results in decreased activity of HTR2A protein; Ketanserin inhibits the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]; Ketanserin inhibits the reaction [Cocaine promotes the reaction [[4-iodo-2,5-dimethoxyphenylisopropylamine binds to and results in increased activity of HTR2A protein] which results in increased secretion of and results in increased abundance of Dopamine]]; Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]; Risperidone inhibits the reaction [Ketanserin binds to HTR2A protein]
4-iodo-2,5-dimethoxyphenylisopropylamine inhibits the reaction [Ketanserin binds to HTR2A protein]; cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Ketanserin binds to HTR2A protein]; HU 211 inhibits the reaction [Ketanserin binds to HTR2A protein]; Ketanserin binds to and results in decreased activity of HTR2A protein
CTD PMID:2891550 PMID:10773215 PMID:10978843 PMID:11927170 PMID:16314884 PMID:16528294 PMID:17031071 PMID:17035140 PMID:18417104 PMID:18784348 PMID:19879056 PMID:20600638 PMID:22048642 PMID:29458138 PMID:29748632 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 multiple interactions ISO [Ketanserin binds to and results in decreased activity of HTR7 protein] inhibits the reaction [5-carboxamidotryptamine results in increased abundance of Cyclic AMP] CTD PMID:14578406 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Ketanserin inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:11076827 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]] CTD PMID:22975078 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ketanserin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK1 protein] CTD PMID:22048642 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Ketanserin inhibits the reaction [Tobacco Smoke Pollution results in increased phosphorylation of MAPK3 protein] CTD PMID:22048642 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO Ketanserin inhibits the reaction [Tobacco Smoke Pollution affects the localization of NFE2L2 protein] CTD PMID:22048642 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO Ketanserin inhibits the reaction [Serotonin results in increased phosphorylation of PPP1R1B protein] CTD PMID:11880652 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Slc6a4 solute carrier family 6 member 4 affects binding
multiple interactions
ISO Ketanserin binds to SLC6A4 protein
methamidophos inhibits the reaction [Ketanserin binds to SLC6A4 protein]
CTD PMID:21871486 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta multiple interactions ISO [[Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]]] which results in increased ubiquitination of and results in increased degradation of IRS1 protein; [Ketanserin inhibits the reaction [Serotonin results in increased activity of AKT1 protein]] promotes the reaction [Serotonin inhibits the reaction [IRS1 protein binds to YWHAB protein]] CTD PMID:22975078 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931
JBrowse link

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              ketanserin 17
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  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
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              atomic nucleus 19779
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                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      ketone 16828
                                        aromatic ketone 12095
                                          ketanserin 17
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