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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 3.5.1.98 (histone deacetylase) inhibitor
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Accession:CHEBI:61115 term browser browse the term
Definition:An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
Synonyms:related_synonym: EC 3.5.1.98 inhibitor;   EC 3.5.1.98 inhibitors;   HDAC inhibitor;   HDAC inhibitors;   HDACi;   HDACis;   HDI;   HDIs;   histone amidohydrolase inhibitor;   histone amidohydrolase inhibitors;   histone deacetylase (EC 3.5.1.98) inhibitors;   histone deacetylase inhibitor;   histone deacetylase inhibitors
 xref: Wikipedia:Histone_deacetylase_inhibitor


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(R)-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 increases uptake EXP SLC22A5 protein results in increased uptake of Carnitine CTD PMID:16826461 NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219 		JBrowse link
4-phenylbutyric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP 4-phenylbutyric acid inhibits the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form] CTD PMID:34637808 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
CAR(3:0(Me2)) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 decreases activity EXP pivaloylcarnitine results in decreased activity of SLC22A5 protein CTD PMID:16826461 NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219 		JBrowse link
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP Chlorogenic Acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL8 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:27861533 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27861533 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:27861533 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27861533 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
curcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO2 aconitase 2 multiple interactions EXP Curcumin inhibits the reaction [maleic acid results in decreased activity of ACO2 protein] CTD PMID:25119790 NCBI chr 5:7,014,383...7,071,023
Ensembl chr 5:7,008,719...7,071,025 		JBrowse link
nicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXO1 forkhead box O1 increases expression EXP Niacinamide results in increased expression of FOXO1 mRNA CTD PMID:17851734 NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma increases expression EXP Niacinamide results in increased expression of PPARG mRNA CTD PMID:17851734 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
G SIRT1 sirtuin 1 decreases expression EXP Niacinamide results in decreased expression of SIRT1 mRNA CTD PMID:17851734 NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297 		JBrowse link
O-acetyl-L-carnitine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 increases uptake EXP SLC22A5 protein results in increased uptake of Acetylcarnitine CTD PMID:16826461 NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219 		JBrowse link
panobinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HDAC1 histone deacetylase 1 multiple interactions EXP Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein] CTD PMID:29080797 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,411 		JBrowse link
phenethyl caffeate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP caffeic acid phenethyl ester inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein] CTD PMID:18845708 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884 		JBrowse link
rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP rosmarinic acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998 		JBrowse link
sulforaphane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP sulforaphane inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:21130106 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
G FIS1 fission, mitochondrial 1 decreases expression EXP sulforaphane results in decreased expression of FIS1 protein CTD PMID:27993529 NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
increases activity
multiple interactions		 EXP sulforaphane results in increased expression of GCLC mRNA
sulforaphane results in increased activity of GCLC protein
Buthionine Sulfoximine inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]; ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]		 CTD PMID:18547363 PMID:20732396 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530 		JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions
increases expression		 EXP ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GSTA1 mRNA] CTD PMID:18547363 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,548,670 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 EXP NFE2L2 protein affects the reaction [sulforaphane results in increased expression of HMOX1 protein] CTD PMID:28710020
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 increases expression EXP sulforaphane results in increased expression of ND1 protein CTD PMID:27993529 NCBI chr MT:3,922...4,876
Ensembl chr MT:3,922...4,876 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity
affects localization
increases expression		 EXP NFE2L2 protein affects the reaction [sulforaphane results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [sulforaphane results in increased expression of NQO1 protein]; ochratoxin A inhibits the reaction [sulforaphane affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased expression of NFE2L2 mRNA]; sulforaphane results in increased expression of and results in increased activity of NFE2L2 protein CTD PMID:18547363 PMID:19913604 PMID:21130106 PMID:28710020 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases activity		 EXP Dicumarol inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]]; NFE2L2 protein affects the reaction [sulforaphane results in increased expression of NQO1 protein]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]
sulforaphane results in increased activity of NQO1 protein		 CTD PMID:20732396 PMID:28710020 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590 		JBrowse link
G NRF1 nuclear respiratory factor 1 increases expression EXP sulforaphane results in increased expression of NRF1 protein CTD PMID:27993529 NCBI chr18:19,008,408...19,142,678
Ensembl chr18:18,998,930...19,142,628 		JBrowse link
G TFAM transcription factor A, mitochondrial increases expression EXP sulforaphane results in increased expression of TFAM protein CTD PMID:27993529 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,731 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP sulforaphane inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA] CTD PMID:28710020 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 1193
    role 1146
      biological role 1136
        biochemical role 1028
          enzyme inhibitor 449
            EC 3.* (hydrolase) inhibitor 389
              EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor 360
                EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor 358
                  EC 3.5.1.98 (histone deacetylase) inhibitor 22
                    3',4'-dihydroxyaurone 0
                    4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide 0
                    4-phenylbutyric acid 1
                    BML-210 0
                    BPDZ 711 0
                    CG-1521 0
                    CHIC-35 0
                    HC toxin 0
                    MC1568 0
                    Sir1 inhibitor + 0
                    Sir2 inhibitor + 3
                    belinostat 0
                    bis-(4-hydroxybenzyl)sulfide 0
                    butyrate + 1
                    caffeic acid + 5
                    carbamazepine + 0
                    curcumin + 1
                    depudecin + 0
                    entinostat + 0
                    methylseleninic acid 0
                    nicotinamide + 3
                    panobinostat 1
                    panobinostat lactate 0
                    pracinostat 0
                    pyridin-3-ylmethyl \{4-[(2-amino-4-fluorophenyl)carbamoyl]benzyl\}carbamate 0
                    romidepsin 0
                    sirtinol 0
                    sodium butyrate 0
                    sodium phenylbutyrate 0
                    spiruchostatin B 0
                    sulforaphane + 11
                    tacedinaline 0
                    trapoxin A 0
                    tributyrin 0
                    trichostatin A + 0
                    tubastatin A 0
                    valproic acid + 0
                    vorinostat 0
paths to the root