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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.5.1.98 (histone deacetylase) inhibitor
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Accession:CHEBI:61115 term browser browse the term
Definition:An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
Synonyms:related_synonym: EC 3.5.1.98 inhibitor;   EC 3.5.1.98 inhibitors;   HDAC inhibitor;   HDAC inhibitors;   HDACi;   HDACis;   HDI;   HDIs;   histone amidohydrolase inhibitor;   histone amidohydrolase inhibitors;   histone deacetylase (EC 3.5.1.98) inhibitors;   histone deacetylase inhibitor;   histone deacetylase inhibitors
 xref: Wikipedia:Histone_deacetylase_inhibitor



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nicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions
EXP Niacinamide results in increased expression of PPARG protein
Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein]
CTD PMID:22539994 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981
JBrowse link
G RUNX2 RUNX family transcription factor 2 increases acetylation
multiple interactions
decreases expression
EXP Niacinamide results in increased acetylation of RUNX2 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]
CTD PMID:22539994 NCBI chr12:13,723,535...13,842,565
Ensembl chr12:13,628,539...13,840,785
Ensembl chr12:13,628,539...13,840,785
JBrowse link
G SIRT1 sirtuin 1 decreases expression
multiple interactions
EXP Niacinamide results in decreased expression of SIRT1 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein]
CTD PMID:22539994 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
valproic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 decreases activity EXP Valproic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
vorinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASQ1 calsequestrin 1 decreases expression EXP Vorinostat results in decreased expression of CASQ1 mRNA CTD PMID:27255383 NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383
JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Vorinostat results in decreased expression of HSP70 mRNA CTD PMID:27255383 NCBI chr12:1,285,282...1,287,670 JBrowse link
G TNNI3K TNNI3 interacting kinase decreases expression EXP Vorinostat results in decreased expression of TNNI3K mRNA CTD PMID:27255383 NCBI chr 6:71,825,853...72,107,832
Ensembl chr 6:71,815,734...72,119,476
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 402
    role 402
      biological role 402
        biochemical role 362
          enzyme inhibitor 273
            EC 3.* (hydrolase) inhibitor 256
              EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor 235
                EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor 235
                  EC 3.5.1.98 (histone deacetylase) inhibitor 7
                    3',4'-dihydroxyaurone 0
                    4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide 0
                    4-phenylbutyric acid 0
                    BML-210 0
                    BPDZ 711 0
                    CG-1521 0
                    CHIC-35 0
                    HC toxin 0
                    MC1568 0
                    Sir1 inhibitor + 0
                    Sir2 inhibitor + 3
                    belinostat 0
                    bis-(4-hydroxybenzyl)sulfide 0
                    butyrate + 0
                    caffeic acid + 0
                    carbamazepine + 0
                    curcumin + 0
                    depudecin + 0
                    entinostat + 0
                    methylseleninic acid 0
                    nicotinamide + 3
                    panobinostat 0
                    panobinostat lactate 0
                    pracinostat 0
                    pyridin-3-ylmethyl \{4-[(2-amino-4-fluorophenyl)carbamoyl]benzyl\}carbamate 0
                    romidepsin 0
                    sirtinol 0
                    sodium butyrate 0
                    sodium phenylbutyrate 0
                    spiruchostatin B 0
                    sulforaphane + 0
                    tacedinaline 0
                    trapoxin A 0
                    tributyrin 0
                    trichostatin A + 0
                    tubastatin A 0
                    valproic acid + 1
                    vorinostat 3
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