Term: | romidepsin |
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Accession: | CHEBI:61080
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Definition: | A cyclodepsipeptide consisting of the cyclic disulfide of (2Z)-2-aminobut-2-enoyl, L-valyl, (3S,4E)-3-hydroxy-7-sulfanylhept-4-enoyl, D-valyl and D-cysteinyl residues coupled in sequence and cyclised head-to tail. |
Synonyms: | exact_synonym: | (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone |
| related_synonym: | Antibiotic FR 901228; Chromadax; FK228; FR901228; Formula=C24H36N4O6S2; InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1; InChIKey=OHRURASPPZQGQM-GCCNXGTGSA-N; Istodax; NSC-630176; SMILES=C\\C=C1/NC(=O)[C@H]2CSSCC\\C=C\\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C; romidepsina; romidepsine; romidepsinum |
| alt_id: | CHEBI:69482 |
| xref: | CAS:128517-07-7; Drug_Central:4119; KEGG:D06637 |
| xref_mesh: | MESH:C087123 |
| xref: | PMID:18205373; PMID:20645688; PMID:21110829; PMID:7513682; PMID:8175483; Reaxys:6854221; Wikipedia:Romidepsin |
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