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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:8-chloro-2'-deoxyguanosine
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Accession:CHEBI:61070 term browser browse the term
Definition:An organochlorine compound comprising 2'-deoxyguanosine having a chloro substituent at position 8 of the guanine ring system.
Synonyms:related_synonym: 8-Cl-2'-dG;   8-chloro-2'-dG;   Formula=C10H12ClN5O4;   InChI=1S/C10H12ClN5O4/c11-9-13-6-7(14-10(12)15-8(6)19)16(9)5-1-3(18)4(2-17)20-5/h3-5,17-18H,1-2H2,(H3,12,14,15,19)/t3-,4+,5+/m0/s1;   InChIKey=IMJGYHICYATNGZ-VPENINKCSA-N;   SMILES=Nc1nc2n([C@H]3C[C@H](O)[C@@H](CO)O3)c(Cl)nc2c(=O)[nH]1
 xref_mesh: MESH:C506093
 xref: PMID:20081197;   Reaxys:10193533


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8-chloro-2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO 8-chloro-2'-deoxyguanosine results in decreased expression of CCL5 mRNA CTD PMID:31066272 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,738,651...68,824,884 		JBrowse link
G Il18 interleukin 18 increases expression ISO 8-chloro-2'-deoxyguanosine results in increased expression of IL18 mRNA CTD PMID:31066272 NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:59,809,592...59,831,286 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion 		ISO 8-chloro-2'-deoxyguanosine results in increased expression of IL1B mRNA
8-chloro-2'-deoxyguanosine results in increased secretion of IL1B protein 		CTD PMID:31066272 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      molecular entity 20859
        polyatomic entity 20803
          heteroatomic molecular entity 20740
            halide 19179
              organohalogen compound 18997
                organochlorine compound 18749
                  8-chloro-2'-deoxyguanosine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbohydrates and carbohydrate derivatives 15487
                                    carbohydrate 15487
                                      carbohydrate derivative 14459
                                        glycosyl compound 13167
                                          N-glycosyl compound 5902
                                            nucleoside 5754
                                              ribonucleoside 1162
                                                purine ribonucleoside 829
                                                  guanosines 40
                                                    8-chloro-2'-deoxyguanosine 3
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