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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:8-chloro-2'-deoxyguanosine
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Accession:CHEBI:61070 term browser browse the term
Definition:An organochlorine compound comprising 2'-deoxyguanosine having a chloro substituent at position 8 of the guanine ring system.
Synonyms:related_synonym: 8-Cl-2'-dG;   8-chloro-2'-dG;   Formula=C10H12ClN5O4;   InChI=1S/C10H12ClN5O4/c11-9-13-6-7(14-10(12)15-8(6)19)16(9)5-1-3(18)4(2-17)20-5/h3-5,17-18H,1-2H2,(H3,12,14,15,19)/t3-,4+,5+/m0/s1;   InChIKey=IMJGYHICYATNGZ-VPENINKCSA-N;   SMILES=Nc1nc2n([C@H]3C[C@H](O)[C@@H](CO)O3)c(Cl)nc2c(=O)[nH]1
 xref_mesh: MESH:C506093
 xref: PMID:20081197;   Reaxys:10193533


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8-chloro-2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO 8-chloro-2'-deoxyguanosine results in decreased expression of CCL5 mRNA CTD PMID:31066272 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Il18 interleukin 18 increases expression ISO 8-chloro-2'-deoxyguanosine results in increased expression of IL18 mRNA CTD PMID:31066272 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion		 ISO 8-chloro-2'-deoxyguanosine results in increased expression of IL1B mRNA
8-chloro-2'-deoxyguanosine results in increased secretion of IL1B protein		 CTD PMID:31066272 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      molecular entity 19821
        polyatomic entity 19743
          heteroatomic molecular entity 19685
            halide 18160
              organohalogen compound 17943
                organochlorine compound 17753
                  8-chloro-2'-deoxyguanosine 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            heteroorganic entity 19301
                              organochalcogen compound 19073
                                organooxygen compound 19024
                                  carbohydrates and carbohydrate derivatives 12345
                                    carbohydrate 12345
                                      carbohydrate derivative 11951
                                        glycosyl compound 10983
                                          N-glycosyl compound 5520
                                            nucleoside 5381
                                              ribonucleoside 678
                                                purine ribonucleoside 572
                                                  guanosines 36
                                                    8-chloro-2'-deoxyguanosine 3
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