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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:61058 term browser browse the term
Definition:A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring.
Synonyms:related_synonym: (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;   (S)-(-)-alpha-Methyldopa;   3-Hydroxy-alpha-methyl-L-tyrosine;   AMD;   Alpha medopa;   Alphamethyldopa;   Formula=C10H13NO4;   InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1;   InChIKey=CJCSPKMFHVPWAR-JTQLQIEISA-N;   L(-)-beta-(3,4-Dihydroxyphenyl)-alpha-methylalanine;   L-(alpha-Md);   L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid;   L-alpha-Methyl-3,4-dihydroxyphenylalanine;   L-alpha-Methyldopa;   Methyl-L-dopa;   Methyldopa anhydrous;   SMILES=C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O;   alpha-Methyl dopa;   alpha-Methyl-beta-(3,4-dihydroxyphenyl)-L-alanine;   alpha-Methyldihydroxyphenylalanine;   alpha-Methyldopa;   l-3-(3,4-Dihydroxyphenyl)-2-methylalanine;   levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine;   methyldopa;   methyldopum;   metildopa
 xref: CAS:555-30-6;   DrugBank:DB00968;   Drug_Central:1762;   HMDB:HMDB0011754;   KEGG:C07194;   KEGG:D08205;   LINCS:LSM-5596
 xref_mesh: MESH:D008750
 xref: PMID:10576686;   PMID:11901210;   PMID:29438107;   PMID:8301021;   Reaxys:2807721;   Wikipedia:Methyldopa

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alpha-methyl-L-dopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation
decreases activity
ISO COMT protein results in increased methylation of Methyldopa
Methyldopa results in decreased activity of COMT protein
CTD PMID:7053299 PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Prl prolactin increases expression
increases secretion
ISO Methyldopa results in increased expression of PRL protein
Methyldopa results in increased secretion of PRL protein
CTD PMID:1867878 PMID:7265421 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ren renin decreases activity EXP Methyldopa results in decreased activity of REN protein CTD PMID:145319 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        hapten 3021
          alpha-methyl-L-dopa 6
            3-methoxy-alpha-methyl-L-tyrosine 0
            alpha-methyl-L-dopa ethyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      s-block molecular entity 19502
                        hydrogen molecular entity 19498
                          hydrides 18852
                            organic hydride 18353
                              organic fundamental parent 18353
                                hydrocarbon 18066
                                  cyclic hydrocarbon 17078
                                    monocyclic hydrocarbon 5831
                                      annulene 5656
                                        aromatic annulene 5656
                                          benzene 5656
                                            alkylbenzene 3372
                                              methylbenzene 3237
                                                toluene 3103
                                                  benzyl group 2517
                                                    phenylalanine 2517
                                                      phenylalanine derivative 2507
                                                        tyrosine derivative 423
                                                          L-tyrosine derivative 6
                                                            alpha-methyl-L-dopa 6
                                                              3-methoxy-alpha-methyl-L-tyrosine 0
                                                              alpha-methyl-L-dopa ethyl ester 0
paths to the root