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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-methyl-L-dopa
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Accession:CHEBI:61058 term browser browse the term
Definition:A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring.
Synonyms:related_synonym: (2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;   (S)-(-)-alpha-Methyldopa;   3-Hydroxy-alpha-methyl-L-tyrosine;   AMD;   Alpha medopa;   Alphamethyldopa;   Formula=C10H13NO4;   InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)/t10-/m0/s1;   InChIKey=CJCSPKMFHVPWAR-JTQLQIEISA-N;   L(-)-beta-(3,4-Dihydroxyphenyl)-alpha-methylalanine;   L-(alpha-Md);   L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic acid;   L-alpha-Methyl-3,4-dihydroxyphenylalanine;   L-alpha-Methyldopa;   Methyl-L-dopa;   Methyldopa anhydrous;   SMILES=C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O;   alpha-Methyl dopa;   alpha-Methyl-beta-(3,4-dihydroxyphenyl)-L-alanine;   alpha-Methyldihydroxyphenylalanine;   alpha-Methyldopa;   l-3-(3,4-Dihydroxyphenyl)-2-methylalanine;   levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine;   methyldopa;   methyldopum;   metildopa
 xref: CAS:555-30-6;   DrugBank:DB00968;   Drug_Central:1762;   HMDB:HMDB0011754;   KEGG:C07194;   KEGG:D08205;   LINCS:LSM-5596
 xref_mesh: MESH:D008750
 xref: PMID:10576686;   PMID:11901210;   PMID:29438107;   PMID:8301021;   Reaxys:2807721;   Wikipedia:Methyldopa


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alpha-methyl-L-dopa term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation
decreases activity
ISO COMT protein results in increased methylation of Methyldopa
Methyldopa results in decreased activity of COMT protein
CTD PMID:7053299, PMID:11160877 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTA1 protein CTD PMID:8131222 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTM1 protein CTD PMID:8131222 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Methyldopa analog results in decreased activity of GSTP1 protein CTD PMID:8131222 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Prl prolactin increases expression
increases secretion
ISO Methyldopa results in increased expression of PRL protein
Methyldopa results in increased secretion of PRL protein
CTD PMID:1867878, PMID:7265421 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ren renin decreases activity EXP Methyldopa results in decreased activity of REN protein CTD PMID:145319 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        hapten 3006
          alpha-methyl-L-dopa 6
            3-methoxy-alpha-methyl-L-tyrosine 0
            alpha-methyl-L-dopa ethyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  cyclic hydrocarbon 17065
                                    monocyclic hydrocarbon 5767
                                      annulene 5593
                                        aromatic annulene 5593
                                          benzene 5593
                                            alkylbenzene 3345
                                              methylbenzene 3207
                                                toluene 3070
                                                  benzyl group 2480
                                                    phenylalanine 2480
                                                      phenylalanine derivative 2472
                                                        tyrosine derivative 400
                                                          L-tyrosine derivative 6
                                                            alpha-methyl-L-dopa 6
                                                              3-methoxy-alpha-methyl-L-tyrosine 0
                                                              alpha-methyl-L-dopa ethyl ester 0
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