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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tacrolimus (anhydrous)
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Accession:CHEBI:61049 term browser browse the term
Definition:A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.
Synonyms:exact_synonym: (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,19-dihydroxy-3-{(1E)-1-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]prop-1-en-2-yl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(prop-2-en-1-yl)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-3H-15,19-epoxypyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone
 related_synonym: 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN;   FK 506;   FK506;   Formula=C44H69NO12;   InChI=1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1;   InChIKey=QJJXYPPXXYFBGM-LFZNUXCKSA-N;   Prograf;   SMILES=CO[C@@H]1C[C@@H](CC[C@H]1O)\\C=C(/C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@H]([C@H](C[C@@H](C)C\\C(C)=C\\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]1C)OC)[C@H](C[C@H]2C)OC;   Tacrolimus
 alt_id: CHEBI:42555;   CHEBI:4958
 xref: CAS:104987-11-3;   DrugBank:DB00864;   KEGG:C01375;   KEGG:D08556;   LIPID_MAPS_instance:LMPK04000003;   PDBeChem:FK5;   Patent:EP184162;   Patent:US5665727;   Reaxys:3647477;   Reaxys:8821611


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tacrolimus hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Tacrolimus results in increased expression of A2M mRNA CTD PMID:21865292 NCBI chr 4:154,309,426...154,359,138
Ensembl chr 4:154,309,426...154,359,137
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO
EXP
[Sirolimus co-treated with Tacrolimus] results in increased expression of ABCA1 protein
Tacrolimus results in increased expression of ABCA1 mRNA
CTD PMID:17016853, PMID:21865292 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Tacrolimus results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects export
decreases activity
multiple interactions
increases response to substance
increases export
affects response to substance
ISO ABCB1 protein affects the export of Tacrolimus
Tacrolimus results in decreased activity of ABCB1 protein
[Tacrolimus binds to ABCB1 protein] inhibits the reaction [azidoprazosin binds to ABCB1 protein]; [Tacrolimus results in decreased activity of ABCB1 protein] which results in decreased export of Dexamethasone; Verapamil affects the reaction [ABCB1 protein results in increased export of Tacrolimus]
ABCB1 gene SNP results in increased susceptibility to Tacrolimus
ABCB1 protein affects the susceptibility to Tacrolimus
CTD PMID:1381629, PMID:11920757, PMID:12352921, PMID:15919446, PMID:15964336, PMID:20080907 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B decreases expression ISO Tacrolimus results in decreased expression of ACAA1B mRNA CTD PMID:25270620 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain decreases expression ISO Tacrolimus results in decreased expression of ACADL mRNA CTD PMID:25270620 NCBI chr 9:73,833,368...73,871,857
Ensembl chr 9:73,833,388...73,871,888
JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression EXP Tacrolimus results in decreased expression of ACE2 mRNA CTD PMID:21865292 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Tacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein] CTD PMID:15207740 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Acta2 actin alpha 2, smooth muscle increases expression ISO Tacrolimus results in increased expression of ACTA2 protein CTD PMID:29362864 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Acvr1b activin A receptor type 1B multiple interactions ISO [Tacrolimus inhibits the reaction [FKBP1A protein binds to ACVR1B protein]] which results in decreased ubiquitination of ACVR1B protein; Tacrolimus inhibits the reaction [FKBP1A protein binds to and results in decreased activity of ACVR1B protein]; Tacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]] CTD PMID:16720724 NCBI chr 7:142,817,174...142,858,365
Ensembl chr 7:142,817,157...142,860,572
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Tacrolimus results in increased expression of ADAMTS1 mRNA CTD PMID:21865292 NCBI chr11:25,342,119...25,350,938
Ensembl chr11:25,342,126...25,350,974
JBrowse link
G Adamts2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 increases expression ISO Tacrolimus results in increased expression of ADAMTS2 mRNA CTD PMID:29362864 NCBI chr10:36,098,051...36,304,416
Ensembl chr10:36,098,051...36,304,409
JBrowse link
G Adra1d adrenoceptor alpha 1D increases expression EXP Tacrolimus results in increased expression of ADRA1D mRNA CTD PMID:21865292 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression ISO Tacrolimus results in increased expression of AIF1 mRNA CTD PMID:29362864 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO Tacrolimus results in decreased expression of ALDH1A1 mRNA CTD PMID:25270620 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression ISO Tacrolimus results in decreased expression of ALDH2 mRNA CTD PMID:25270620 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 decreases expression ISO Tacrolimus results in decreased expression of ALDH9A1 mRNA CTD PMID:25270620 NCBI chr13:85,580,828...85,597,497
Ensembl chr13:85,580,828...85,597,493
JBrowse link
G Alg3 ALG3, alpha-1,3- mannosyltransferase decreases expression ISO Tacrolimus results in decreased expression of ALG3 mRNA CTD PMID:25270620 NCBI chr11:83,985,484...83,991,706
Ensembl chr11:83,986,230...83,991,706
JBrowse link
G Angptl6 angiopoietin-like 6 increases expression EXP Tacrolimus results in increased expression of ANGPTL6 mRNA CTD PMID:21865292 NCBI chr 8:21,895,523...21,902,002
Ensembl chr 8:21,895,524...21,901,829
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression ISO Tacrolimus results in increased expression of ANKRD1 mRNA CTD PMID:29362864 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Ankrd34a ankyrin repeat domain 34A decreases expression ISO Tacrolimus results in decreased expression of ANKRD34A mRNA CTD PMID:25270620 NCBI chr 2:198,720,277...198,725,155
Ensembl chr 2:198,721,724...198,725,154
JBrowse link
G Anos1 anosmin 1 increases expression ISO Tacrolimus results in increased expression of WFDC17 mRNA CTD PMID:29362864 Ensembl chr10:70,999,780...71,000,627 JBrowse link
G Anpep alanyl aminopeptidase, membrane increases secretion EXP Tacrolimus results in increased secretion of ANPEP protein CTD PMID:7514309 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273
JBrowse link
G Anxa1 annexin A1 increases expression EXP Tacrolimus results in increased expression of ANXA1 CTD PMID:20484890 NCBI chr 1:237,893,983...237,910,002
Ensembl chr 1:237,893,966...237,910,012
JBrowse link
G Aoc1 amine oxidase, copper containing 1 increases expression ISO Tacrolimus results in increased expression of AOC1 mRNA CTD PMID:29362864 NCBI chr 4:78,496,043...78,515,582
Ensembl chr 4:78,496,043...78,515,584
JBrowse link
G Areg amphiregulin increases expression EXP Tacrolimus results in increased expression of AREG mRNA CTD PMID:21865292 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arfrp1 ADP-ribosylation factor related protein 1 increases expression ISO Tacrolimus results in increased expression of ARFRP1 mRNA CTD PMID:25270620 NCBI chr 3:176,857,667...176,865,105
Ensembl chr 3:176,859,151...176,865,103
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 increases expression ISO Tacrolimus results in increased expression of ARHGAP45 mRNA CTD PMID:21621594 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
JBrowse link
G Arhgef11 Rho guanine nucleotide exchange factor 11 increases expression ISO Tacrolimus results in increased expression of ARHGEF11 mRNA CTD PMID:29380240 NCBI chr 2:186,979,850...187,102,523
Ensembl chr 2:186,980,793...187,101,768
JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 increases expression ISO Tacrolimus results in increased expression of ARPC5 mRNA CTD PMID:29380240 NCBI chr13:70,174,970...70,183,879
Ensembl chr13:70,174,936...70,183,879
JBrowse link
G Arv1 ARV1 homolog, fatty acid homeostasis modulator increases expression ISO Tacrolimus results in increased expression of ARV1 mRNA CTD PMID:25270620 NCBI chr19:57,484,720...57,496,539
Ensembl chr19:57,484,634...57,496,695
JBrowse link
G Asxl3 ASXL transcriptional regulator 3 decreases expression ISO Tacrolimus results in decreased expression of ASXL3 mRNA CTD PMID:29362864 NCBI chr18:13,322,148...13,496,230
Ensembl chr18:13,386,133...13,491,735
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Tacrolimus results in increased expression of ATF3 mRNA CTD PMID:23958496 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Tacrolimus results in increased expression of ATF4 mRNA CTD PMID:23958496 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO Tacrolimus results in increased expression of ATF6 mRNA CTD PMID:23958496 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression ISO Tacrolimus results in decreased expression of ATP1B1 mRNA CTD PMID:25270620 NCBI chr13:82,737,161...82,757,681
Ensembl chr13:82,737,159...82,758,004
JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 decreases expression ISO Tacrolimus results in decreased expression of ATP1B3 mRNA CTD PMID:25270620 NCBI chr 8:104,190,032...104,221,342
Ensembl chr 8:104,190,032...104,221,342
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression ISO Tacrolimus results in increased expression of ATP2A2 mRNA CTD PMID:25270620 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G B2m beta-2 microglobulin increases expression ISO Tacrolimus results in increased expression of B2M mRNA CTD PMID:29362864 NCBI chr 3:114,087,287...114,093,311
Ensembl chr 3:114,087,287...114,093,309
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP
ISO
Tacrolimus inhibits the reaction [Ammonium Chloride results in decreased phosphorylation of BAD protein]
Tacrolimus inhibits the reaction [Rotenone results in decreased phosphorylation of BAD protein]
CTD PMID:15036616, PMID:15280438 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Batf3 basic leucine zipper ATF-like transcription factor 3 increases expression ISO Tacrolimus results in increased expression of BATF3 mRNA CTD PMID:29362864 NCBI chr13:109,713,376...109,726,438
Ensembl chr13:109,713,489...109,724,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BAX protein]
[Tacrolimus co-treated with 3-nitropropionic acid] affects the localization of BAX protein
CTD PMID:10205001, PMID:15571979 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of BCL2 protein]
[Tacrolimus co-treated with 3-nitropropionic acid] affects the localization of BCL2 protein
Tacrolimus results in increased expression of BCL2 protein
CTD PMID:10205001, PMID:15571979 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Tacrolimus inhibits the reaction [Superantigens results in increased expression of BCL2L1 protein] CTD PMID:10532544 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression ISO Tacrolimus results in increased expression of BCL3 mRNA CTD PMID:23958496 NCBI chr 1:80,730,758...80,745,273
Ensembl chr 1:80,730,499...80,744,831
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Tacrolimus inhibits the reaction [decamethrin results in increased expression of BDNF exon]; Tacrolimus promotes the reaction [U 0126 inhibits the reaction [decamethrin results in increased expression of BDNF exon]]; U 0126 promotes the reaction [Tacrolimus inhibits the reaction [decamethrin results in increased expression of BDNF exon]] CTD PMID:22079160 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression EXP Tacrolimus results in increased expression of BIRC3 mRNA CTD PMID:21865292 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Tacrolimus results in decreased expression of BIRC5 mRNA CTD PMID:16574167 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions
decreases expression
EXP Ramipril inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein]; valsartan inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] CTD PMID:17703430 NCBI chr 3:170,879,972...170,955,820
Ensembl chr 3:170,879,973...170,955,399
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP Tacrolimus results in increased expression of BTG2 mRNA CTD PMID:21865292 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Btnl9 butyrophilin-like 9 decreases expression ISO Tacrolimus results in decreased expression of BTNL9 mRNA CTD PMID:29362864 NCBI chr10:34,424,830...34,443,749
Ensembl chr10:34,425,069...34,439,470
JBrowse link
G C1qa complement C1q A chain increases expression ISO Tacrolimus results in increased expression of C1QA mRNA CTD PMID:29362864 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C1qb complement C1q B chain increases expression ISO Tacrolimus results in increased expression of C1QB mRNA CTD PMID:29362864 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
JBrowse link
G C1qc complement C1q C chain increases expression ISO Tacrolimus results in increased expression of C1QC mRNA CTD PMID:29362864 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G C2 complement C2 increases expression EXP Tacrolimus results in increased expression of C2 mRNA CTD PMID:21865292 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152
JBrowse link
G C3 complement C3 increases expression EXP
ISO
Tacrolimus results in increased expression of C3 mRNA CTD PMID:21865292, PMID:29362864 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C4b complement C4B (Chido blood group) increases expression EXP Tacrolimus results in increased expression of C4B mRNA CTD PMID:21865292 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G Calb1 calbindin 1 decreases expression EXP Tacrolimus results in decreased expression of CALB1 mRNA; Tacrolimus results in decreased expression of CALB1 protein CTD PMID:14978156, PMID:21865292 NCBI chr 5:29,538,380...29,562,774
Ensembl chr 5:29,538,380...29,562,773
JBrowse link
G Calcr calcitonin receptor multiple interactions ISO Tacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564 NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
JBrowse link
G Calr calreticulin increases expression ISO Tacrolimus results in increased expression of CALR mRNA CTD PMID:25270620 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Camk1d calcium/calmodulin-dependent protein kinase ID increases expression ISO Tacrolimus results in increased expression of CAMK1D mRNA CTD PMID:23958496 NCBI chr17:76,532,611...76,938,956
Ensembl chr17:76,532,611...76,938,956
JBrowse link
G Capg capping actin protein, gelsolin like increases expression EXP Tacrolimus results in increased expression of CAPG mRNA CTD PMID:21865292 NCBI chr 4:100,395,693...100,419,447
Ensembl chr 4:100,407,658...100,419,446
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]
Tacrolimus results in increased activity of CASP3 protein
MK0626 inhibits the reaction [Tacrolimus results in increased activity of CASP3 protein]; NGF protein inhibits the reaction [Tacrolimus results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [Oxygen deficiency results in increased activity of CASP3 protein]
Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [S-Nitrosoglutathione results in increased activity of CASP3 protein]
CTD PMID:10205001, PMID:12642403, PMID:12871656, PMID:12892836, PMID:15207740, PMID:15548389, PMID:15571979, PMID:17166486, PMID:17385075, PMID:20149694, PMID:24959755 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP8 protein] CTD PMID:15548389 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP9 protein] CTD PMID:15548389 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression
decreases response to substance
EXP
ISO
Tacrolimus results in increased expression of CAT protein
CAT protein results in decreased susceptibility to Tacrolimus
CTD PMID:14675044, PMID:18766458 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbll1 Cbl proto-oncogene like 1 increases expression ISO Tacrolimus results in increased expression of CBLL1 mRNA CTD PMID:21621594 NCBI chr 6:50,772,718...50,786,861
Ensembl chr 6:50,772,829...50,786,967
JBrowse link
G Ccdc88b coiled-coil domain containing 88B increases expression ISO Tacrolimus results in increased expression of CCDC88B mRNA CTD PMID:29362864 NCBI chr 1:222,102,436...222,118,485
Ensembl chr 1:222,102,437...222,118,459
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases expression ISO Tacrolimus results in decreased expression of CCL11 mRNA CTD PMID:15948978 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl17 C-C motif chemokine ligand 17 increases expression ISO Tacrolimus results in increased expression of CCL17 mRNA CTD PMID:29362864 NCBI chr19:10,619,220...10,620,671
Ensembl chr19:10,619,220...10,620,671
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP
ISO
pyrrolidine dithiocarbamic acid inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]
7-oxozeanol inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; 7-oxozeanol inhibits the reaction [Tacrolimus results in increased expression of CCL2 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tacrolimus results in increased expression of CCL2 protein]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL2 protein]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]; sulforafan inhibits the reaction [Tacrolimus results in increased expression of CCL2 mRNA]
CTD PMID:12472797, PMID:23958496, PMID:29362864 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Tacrolimus results in increased expression of CCL20 mRNA CTD PMID:23958496 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression
increases expression
multiple interactions
ISO Tacrolimus results in decreased expression of CCL5 mRNA
Tacrolimus results in increased expression of CCL5 mRNA
7-oxozeanol inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; parthenolide inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; pyrazolanthrone inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; salubrinal inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]; sulforafan inhibits the reaction [Tacrolimus results in increased expression of CCL5 mRNA]
CTD PMID:15948978, PMID:23958496, PMID:25270620 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 increases expression EXP
ISO
Tacrolimus results in increased expression of CCL6 mRNA CTD PMID:21865292, PMID:29362864 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Tacrolimus results in increased expression of CCL7 mRNA CTD PMID:23958496, PMID:29362864 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccna2 cyclin A2 increases expression ISO Tacrolimus results in increased expression of CCNA2 mRNA CTD PMID:29362864 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb2 cyclin B2 decreases expression
increases expression
ISO Tacrolimus results in decreased expression of CCNB2 mRNA
Tacrolimus results in increased expression of CCNB2 mRNA
CTD PMID:16574167, PMID:29362864 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO Tacrolimus results in increased expression of CCR2 mRNA CTD PMID:29362864
G Ccr3 C-C motif chemokine receptor 3 decreases expression ISO Tacrolimus results in decreased expression of CCR3 mRNA CTD PMID:15948978 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Ccrl2 C-C motif chemokine receptor like 2 increases expression ISO Tacrolimus results in increased expression of CCRL2 mRNA CTD PMID:23958496 NCBI chr 8:119,324,298...119,326,954
Ensembl chr 8:119,324,613...119,326,938
JBrowse link
G Cd2 Cd2 molecule multiple interactions ISO Tacrolimus inhibits the reaction [CD2 protein results in increased expression of IL2 protein] CTD PMID:1705513 NCBI chr 2:203,666,706...203,680,073
Ensembl chr 2:203,666,637...203,680,083
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP Tacrolimus results in increased expression of CD44 mRNA CTD PMID:21865292 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd68 Cd68 molecule increases expression EXP Tacrolimus results in increased expression of CD68 mRNA CTD PMID:21865292 NCBI chr10:56,268,726...56,270,605
Ensembl chr10:56,268,720...56,270,640
JBrowse link
G Cd74 CD74 molecule increases expression ISO Tacrolimus results in increased expression of CD74 mRNA CTD PMID:23958496 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cd80 Cd80 molecule decreases expression ISO Tacrolimus results in decreased expression of CD80 protein CTD PMID:15241357 NCBI chr11:64,815,201...64,855,293
Ensembl chr11:64,827,635...64,855,353
JBrowse link
G Cd83 CD83 molecule increases expression ISO Tacrolimus results in increased expression of CD83 mRNA CTD PMID:29362864 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
JBrowse link
G Cd86 CD86 molecule decreases expression ISO Tacrolimus results in decreased expression of CD86 protein CTD PMID:15241357 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdca3 cell division cycle associated 3 increases expression ISO Tacrolimus results in increased expression of CDCA3 mRNA CTD PMID:29362864 NCBI chr 4:157,347,876...157,351,889
Ensembl chr 4:157,348,020...157,351,604
JBrowse link
G Cdca5 cell division cycle associated 5 increases expression ISO Tacrolimus results in increased expression of CDCA5 mRNA CTD PMID:29362864 NCBI chr 1:221,448,661...221,462,235
Ensembl chr 1:221,448,661...221,462,233
JBrowse link
G Cdca8 cell division cycle associated 8 increases expression ISO Tacrolimus results in increased expression of CDCA8 mRNA CTD PMID:29362864 NCBI chr 5:142,911,310...142,933,536
Ensembl chr 5:142,911,305...142,933,526
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Tacrolimus results in decreased expression of CDH1 protein CTD PMID:22416070 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh11 cadherin 11 increases expression ISO Tacrolimus results in increased expression of CDH11 mRNA CTD PMID:29362864 NCBI chr19:2,391,181...2,551,245
Ensembl chr19:2,393,059...2,551,245
JBrowse link
G Cdh16 cadherin 16 decreases expression ISO Tacrolimus results in decreased expression of CDH16 mRNA CTD PMID:22416070 NCBI chr19:568,329...578,513
Ensembl chr19:568,287...578,520
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression EXP Tacrolimus results in increased expression of CDKN1B mRNA CTD PMID:21865292 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO Tacrolimus results in increased expression of CEBPA mRNA CTD PMID:29362864 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cenpw centromere protein W increases expression ISO Tacrolimus results in increased expression of CENPW mRNA CTD PMID:29362864 NCBI chr 1:29,915,443...29,920,598
Ensembl chr 1:29,915,443...29,920,598
JBrowse link
G Cfi complement factor I increases expression EXP Tacrolimus results in increased expression of CFI mRNA CTD PMID:21865292 NCBI chr 2:235,264,149...235,305,779
Ensembl chr 2:235,264,219...235,305,781
JBrowse link
G Ckap2 cytoskeleton associated protein 2 increases expression ISO Tacrolimus results in increased expression of CKAP2 mRNA CTD PMID:29362864 NCBI chr16:74,752,655...74,779,184
Ensembl chr16:74,752,655...74,779,184
JBrowse link
G Ckap4 cytoskeleton-associated protein 4 increases expression EXP Tacrolimus results in increased expression of CKAP4 mRNA CTD PMID:21865292 NCBI chr 7:24,935,243...24,947,595
Ensembl chr 7:24,939,498...24,947,595
JBrowse link
G Cldn1 claudin 1 decreases expression ISO Tacrolimus results in decreased expression of CLDN1 mRNA CTD PMID:22416070 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
JBrowse link
G Cldn4 claudin 4 increases expression EXP Tacrolimus results in increased expression of CLDN4 mRNA CTD PMID:21865292 NCBI chr12:24,761,210...24,763,008
Ensembl chr12:24,761,210...24,763,005
JBrowse link
G Cldn7 claudin 7 increases expression EXP Tacrolimus results in increased expression of CLDN7 mRNA CTD PMID:21865292 NCBI chr10:56,576,326...56,578,632
Ensembl chr10:56,576,428...56,578,626
JBrowse link
G Clec7a C-type lectin domain containing 7A increases expression ISO Tacrolimus results in increased expression of CLEC7A mRNA CTD PMID:29362864 NCBI chr 4:163,216,152...163,227,367
Ensembl chr 4:163,216,163...163,227,334
JBrowse link
G Clk3 CDC-like kinase 3 increases expression ISO Tacrolimus results in increased expression of CLK3 mRNA CTD PMID:25270620 NCBI chr 8:62,528,135...62,543,550
Ensembl chr 8:62,528,225...62,542,622
JBrowse link
G Clu clusterin increases expression EXP Tacrolimus results in increased expression of CLU mRNA CTD PMID:21865292 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Coch cochlin increases expression ISO Tacrolimus results in increased expression of COCH mRNA CTD PMID:25270620 NCBI chr 6:72,359,702...72,373,710
Ensembl chr 6:72,359,791...72,373,695
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Tacrolimus results in increased expression of COL1A1 mRNA CTD PMID:29362864 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Tacrolimus results in increased expression of COL1A2 mRNA CTD PMID:29362864 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Col3a1 collagen type III alpha 1 chain increases expression ISO Tacrolimus results in increased expression of COL3A1 mRNA CTD PMID:29362864 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cops8 COP9 signalosome subunit 8 increases expression ISO Tacrolimus results in increased expression of COPS8 mRNA CTD PMID:25270620 NCBI chr 9:97,772,224...97,782,055
Ensembl chr 9:97,772,184...97,782,067
JBrowse link
G Cp ceruloplasmin increases expression EXP Tacrolimus results in increased expression of CP mRNA CTD PMID:21865292 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 decreases expression ISO Tacrolimus results in decreased expression of CREB3L3 mRNA CTD PMID:25270620 NCBI chr 7:11,490,852...11,499,287
Ensembl chr 7:11,490,852...11,499,282
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression ISO Tacrolimus results in increased expression of CRELD2 mRNA CTD PMID:25270620 NCBI chr 7:129,812,746...129,819,641
Ensembl chr 7:129,812,789...129,819,634
JBrowse link
G Csf1 colony stimulating factor 1 increases expression ISO Tacrolimus results in increased expression of CSF1 mRNA CTD PMID:23958496 NCBI chr 2:210,522,370...210,550,546
Ensembl chr 2:210,522,375...210,550,560
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression
increases expression
multiple interactions
ISO Tacrolimus results in decreased expression of CSF2 protein
Tacrolimus results in increased expression of CSF2 mRNA
Sirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of CSF2 protein]]; Tacrolimus inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CSF2 protein]
CTD PMID:1376361, PMID:11407316, PMID:23958496 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Csf2rb colony stimulating factor 2 receptor subunit beta increases expression ISO Tacrolimus results in increased expression of CSF2RB2 mRNA CTD PMID:29362864 NCBI chr 7:119,554,383...119,568,248
Ensembl chr 7:119,554,354...119,568,776
JBrowse link
G Ctsl cathepsin L multiple interactions
increases expression
ISO
EXP
Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTSL protein]
Tacrolimus results in increased expression of CTSL mRNA
CTD PMID:18172886, PMID:21865292, PMID:25270620 NCBI chr17:1,873,105...1,879,266
Ensembl chr17:1,872,848...1,879,279
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP
ISO
Tacrolimus results in increased expression of CXCL10 mRNA CTD PMID:21865292, PMID:23958496, PMID:25270620 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Tacrolimus results in increased expression of CXCL11 mRNA CTD PMID:23958496 NCBI chr14:17,195,395...17,198,170
Ensembl chr14:17,195,014...17,198,291
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
increases expression
ISO Ramipril inhibits the reaction [Tacrolimus results in increased expression of CYBA mRNA] CTD PMID:12352326 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression EXP Tacrolimus results in increased expression of CYP27B1 mRNA CTD PMID:21865292 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO CYP2C19 affects the reaction [Lansoprazole affects the susceptibility to Tacrolimus]; CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole]; CYP2C19 gene mutant form affects the susceptibility to [Lansoprazole co-treated with Tacrolimus] CTD PMID:15010519, PMID:15285851, PMID:17377957 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
decreases methylation
affects metabolic processing
affects response to substance
ISO CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole]; CYP3A5 gene polymorphism affects the reaction [Ketoconazole results in decreased metabolism of Tacrolimus]
CYP3A5 protein results in decreased methylation of Tacrolimus
CYP3A5 gene polymorphism affects the metabolism of Tacrolimus; CYP3A5 gene SNP affects the metabolism of Tacrolimus; CYP3A5 protein affects the metabolism of Tacrolimus; CYP3A5 protein polymorphism affects the metabolism of Tacrolimus
CYP3A5 gene affects the susceptibility to Tacrolimus
CTD PMID:15502717, PMID:15723604, PMID:15729180, PMID:15808586, PMID:15919447, PMID:15951320, PMID:15964336, PMID:17377957, PMID:19384264 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Dcn decorin increases expression ISO Tacrolimus results in increased expression of DCN mRNA CTD PMID:29362864 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO salubrinal promotes the reaction [Tacrolimus results in increased expression of DDIT3 protein]
Tacrolimus results in increased expression of DDIT3 mRNA
CTD PMID:23958496, PMID:25270620 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like decreases expression EXP Tacrolimus results in decreased expression of DDIT4L mRNA CTD PMID:21865292 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Tacrolimus results in decreased expression of DHCR24 mRNA CTD PMID:25270620 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dnajc30 DnaJ heat shock protein family (Hsp40) member C30 decreases expression ISO Tacrolimus results in decreased expression of DNAJC30 mRNA CTD PMID:25270620 NCBI chr12:24,668,398...24,669,464
Ensembl chr12:24,668,398...24,669,464
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO PINK1 protein affects the reaction [Tacrolimus results in increased phosphorylation of DNM1L protein]
Tacrolimus inhibits the reaction [ferric ammonium citrate results in decreased phosphorylation of DNM1L protein]
CTD PMID:19492085, PMID:26318285 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Doc2a double C2 domain alpha decreases expression ISO Tacrolimus results in decreased expression of DOC2A mRNA CTD PMID:25270620 NCBI chr 1:198,282,828...198,288,611
Ensembl chr 1:198,284,473...198,288,113
JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO Tacrolimus results in increased expression of DOCK10 mRNA CTD PMID:29362864 NCBI chr 9:86,424,638...86,571,854
NCBI chr 9:86,312,470...86,423,054
Ensembl chr 9:86,312,501...86,571,870
JBrowse link
G Dpp4 dipeptidylpeptidase 4 increases activity
multiple interactions
EXP Tacrolimus results in increased activity of DPP4 protein
MK0626 inhibits the reaction [Tacrolimus results in increased activity of DPP4 protein]
CTD PMID:24959755 NCBI chr 3:48,291,055...48,372,672
Ensembl chr 3:48,291,055...48,372,672
JBrowse link
G Drd2 dopamine receptor D2 affects activity
multiple interactions
EXP Tacrolimus affects the activity of DRD2 protein
Sulpiride inhibits the reaction [Tacrolimus affects the activity of DRD2 protein]
CTD PMID:15332494 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression ISO Tacrolimus results in decreased expression of ECH1 mRNA CTD PMID:25270620 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Edem1 ER degradation enhancing alpha-mannosidase like protein 1 increases expression ISO Tacrolimus results in increased expression of EDEM1 mRNA CTD PMID:25270620 NCBI chr 4:140,886,644...140,918,654
Ensembl chr 4:140,886,545...140,915,779
JBrowse link
G Edn1 endothelin 1 increases expression EXP Tacrolimus results in increased expression of EDN1 mRNA; Tacrolimus results in increased expression of EDN1 protein CTD PMID:9517403, PMID:9931093 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A increases activity
increases expression
EXP Tacrolimus results in increased activity of EDNRA protein
Tacrolimus results in increased expression of EDNRA mRNA
CTD PMID:8587392, PMID:15964565 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Efemp2 EGF containing fibulin extracellular matrix protein 2 increases expression ISO Tacrolimus results in increased expression of EFEMP2 mRNA CTD PMID:29362864 NCBI chr 1:220,853,695...220,861,420
Ensembl chr 1:220,854,403...220,861,420
JBrowse link
G Egr1 early growth response 1 increases expression EXP Tacrolimus results in increased expression of EGR1 mRNA CTD PMID:21865292 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Egr2 early growth response 2 increases expression EXP Tacrolimus results in increased expression of EGR2 mRNA CTD PMID:21865292 NCBI chr20:22,452,170...22,461,018
Ensembl chr20:22,454,463...22,459,025
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions ISO Tacrolimus inhibits the reaction [Sirolimus results in decreased phosphorylation of and results in increased activity of EIF4EBP1 protein] CTD PMID:8599949 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Elac2 elaC ribonuclease Z 2 decreases expression ISO Tacrolimus results in decreased expression of ELAC2 mRNA CTD PMID:25270620 NCBI chr10:51,478,378...51,501,167
Ensembl chr10:51,478,378...51,501,165
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of ERN1 protein CTD PMID:23958496 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO Tacrolimus results in increased expression of ERO1A mRNA CTD PMID:23958496 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G Exosc4 exosome component 4 decreases expression ISO Tacrolimus results in decreased expression of EXOSC4 mRNA CTD PMID:25270620 NCBI chr 7:117,390,302...117,393,044
Ensembl chr 7:117,390,285...117,393,719
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO Tacrolimus results in decreased expression of F2R mRNA CTD PMID:25270620 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression ISO Tacrolimus results in decreased expression of FABP2 mRNA CTD PMID:25270620 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP8 protein]; Tacrolimus inhibits the reaction [FAS protein results in increased activity of CASP9 protein] CTD PMID:15548389 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Faslg Fas ligand decreases secretion ISO Tacrolimus results in decreased secretion of FASLG protein CTD PMID:11692113 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fbln1 fibulin 1 increases expression EXP Tacrolimus results in increased expression of FBLN1 mRNA CTD PMID:21865292 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fga fibrinogen alpha chain increases expression EXP Tacrolimus results in increased expression of FGA mRNA CTD PMID:21865292 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgb fibrinogen beta chain increases expression EXP Tacrolimus results in increased expression of FGB mRNA CTD PMID:21865292 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178
JBrowse link
G Fgd2 FYVE, RhoGEF and PH domain containing 2 increases expression ISO Tacrolimus results in increased expression of FGD2 mRNA CTD PMID:29362864 NCBI chr20:6,973,356...6,990,026
Ensembl chr20:6,973,398...6,990,023
JBrowse link
G Fgf21 fibroblast growth factor 21 decreases expression ISO Tacrolimus results in decreased expression of FGF21 mRNA CTD PMID:25270620 NCBI chr 1:101,595,579...101,596,822
Ensembl chr 1:101,595,579...101,596,822
JBrowse link
G Fgl2 fibrinogen-like 2 increases expression EXP
ISO
Tacrolimus results in increased expression of FGL2 mRNA CTD PMID:21865292, PMID:29362864 NCBI chr 4:10,323,598...10,329,241
Ensembl chr 4:10,323,607...10,329,241
JBrowse link
G Fhl2 four and a half LIM domains 2 increases expression ISO Tacrolimus results in increased expression of FHL2 mRNA CTD PMID:29362864 NCBI chr 9:49,920,611...49,994,906
Ensembl chr 9:49,920,854...49,950,093
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions
increases expression
ISO
EXP
[Tacrolimus binds to FKBP1A protein] inhibits the reaction [Sirolimus binds to FKBP1A protein]; [Tacrolimus inhibits the reaction [FKBP1A protein binds to ACVR1B protein]] which results in decreased ubiquitination of ACVR1B protein; Tacrolimus inhibits the reaction [FKBP1A protein binds to and results in decreased activity of ACVR1B protein]; Tacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]]
Tacrolimus results in increased expression of FKBP1A protein
CTD PMID:10361256, PMID:11041285, PMID:16720724 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO Tacrolimus inhibits the reaction [NR3C1 protein binds to FKBP5 protein] CTD PMID:15697228 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 increases expression ISO Tacrolimus results in increased expression of FLT3 mRNA CTD PMID:29362864 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases expression ISO Tacrolimus results in increased expression of FMO2 mRNA CTD PMID:21621594 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression
ISO Tacrolimus inhibits the reaction [NPR1 protein affects the expression of FN1 mRNA]
Tacrolimus results in increased expression of FN1 mRNA
CTD PMID:15939815, PMID:29362864 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fndc3a fibronectin type III domain containing 3a increases expression ISO Tacrolimus results in increased expression of FNDC3A mRNA CTD PMID:25270620 NCBI chr15:54,378,865...54,582,954
Ensembl chr15:54,381,044...54,528,480
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Tacrolimus results in increased expression of FOS mRNA CTD PMID:23958496 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Tacrolimus results in increased expression of FOSL1 mRNA CTD PMID:23958496 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Tacrolimus results in decreased expression of GBP1 mRNA CTD PMID:21621594 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gc GC, vitamin D binding protein decreases expression
increases expression
EXP
ISO
Tacrolimus results in decreased expression of GC mRNA
Tacrolimus results in increased expression of GC mRNA
CTD PMID:21865292, PMID:29362864 NCBI chr14:20,267,023...20,302,577
Ensembl chr14:20,266,891...20,302,581
JBrowse link
G Gcg glucagon multiple interactions
decreases secretion
EXP MK0626 inhibits the reaction [Tacrolimus results in decreased secretion of GCG protein modified form] CTD PMID:24959755 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gins2 GINS complex subunit 2 increases expression ISO Tacrolimus results in increased expression of GINS2 mRNA CTD PMID:29362864 NCBI chr19:54,151,048...54,163,701
Ensembl chr19:54,151,048...54,163,608
JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression ISO Tacrolimus results in increased expression of GJB1 mRNA CTD PMID:21621594 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gldc glycine decarboxylase decreases expression ISO Tacrolimus results in decreased expression of GLDC mRNA CTD PMID:25270620 NCBI chr 1:248,295,140...248,377,122
Ensembl chr 1:248,297,331...248,377,093
JBrowse link
G Glp1r glucagon-like peptide 1 receptor decreases expression
multiple interactions
EXP Tacrolimus results in decreased expression of GLP1R protein
MK0626 inhibits the reaction [Tacrolimus results in decreased expression of GLP1R protein]
CTD PMID:24959755 NCBI chr20:9,586,075...9,626,228
Ensembl chr20:9,586,075...9,626,228
JBrowse link
G Gpihbp1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 decreases expression ISO Tacrolimus results in decreased expression of GPIHBP1 mRNA CTD PMID:29362864 NCBI chr 7:116,632,496...116,635,543
Ensembl chr 7:116,632,506...116,634,293
JBrowse link
G Gpn2 GPN-loop GTPase 2 increases expression ISO Tacrolimus results in increased expression of GPN2 mRNA CTD PMID:25270620 NCBI chr 5:151,806,458...151,813,954
Ensembl chr 5:151,806,458...151,813,954
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Tacrolimus results in increased expression of GPNMB mRNA CTD PMID:21865292 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Grn granulin precursor increases expression ISO Tacrolimus results in increased expression of GRN mRNA CTD PMID:25270620 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions
increases phosphorylation
ISO [GSK3A protein co-treated with GSK3B protein] affects the reaction [Tacrolimus results in increased expression of SNAI1 protein]
Tacrolimus results in increased phosphorylation of GSK3A protein
CTD PMID:22416070 NCBI chr 1:82,097,244...82,108,238
Ensembl chr 1:82,097,247...82,108,203
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO [GSK3A protein co-treated with GSK3B protein] affects the reaction [Tacrolimus results in increased expression of SNAI1 protein]
Tacrolimus results in increased phosphorylation of GSK3B protein
CTD PMID:22416070 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gtpbp4 GTP binding protein 4 decreases expression EXP Tacrolimus results in decreased expression of GTPBP4 mRNA CTD PMID:21865292 NCBI chr17:63,111,086...63,145,618
Ensembl chr17:63,110,254...63,145,577
JBrowse link
G Guca2a guanylate cyclase activator 2A increases expression EXP Tacrolimus results in increased expression of GUCA2A mRNA CTD PMID:21865292 NCBI chr 5:138,685,634...138,687,476
Ensembl chr 5:138,685,624...138,687,816
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression ISO Tacrolimus results in decreased expression of HADHB mRNA CTD PMID:25270620 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases expression EXP Tacrolimus results in increased expression of HAVCR1 mRNA CTD PMID:21865292 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression ISO Tacrolimus results in increased expression of HERPUD1 mRNA CTD PMID:23958496, PMID:25270620 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hexa hexosaminidase subunit alpha increases expression ISO Tacrolimus results in increased expression of HEXA mRNA CTD PMID:25270620 NCBI chr 8:64,325,435...64,350,775
Ensembl chr 8:64,325,435...64,350,773
JBrowse link
G Hgs hepatocyte growth factor-regulated tyrosine kinase substrate increases expression ISO Tacrolimus results in increased expression of HGS mRNA CTD PMID:29380240 NCBI chr10:109,638,944...109,657,460
Ensembl chr10:109,638,767...109,657,456
JBrowse link
G Hk2 hexokinase 2 increases expression ISO Tacrolimus results in increased expression of HK2 mRNA CTD PMID:29362864 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Hk3 hexokinase 3 increases expression ISO Tacrolimus results in increased expression of HK3 mRNA CTD PMID:29362864 NCBI chr17:10,134,726...10,152,976
Ensembl chr17:10,137,974...10,152,956
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Tacrolimus results in decreased expression of HMGCS2 mRNA CTD PMID:25270620 NCBI chr 2:200,452,623...200,480,785
Ensembl chr 2:200,452,624...200,479,423
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Tacrolimus results in increased expression of HMOX1 mRNA; Tacrolimus results in increased expression of HMOX1 protein
Tacrolimus results in decreased expression of HMOX1 protein
MK0626 inhibits the reaction [Tacrolimus results in decreased expression of HMOX1 protein]
CTD PMID:23958496, PMID:24959755, PMID:26260164, PMID:29362864 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf1b HNF1 homeobox B decreases expression ISO Tacrolimus results in decreased expression of HNF1B mRNA CTD PMID:22416070 NCBI chr10:71,159,863...71,218,902
Ensembl chr10:71,159,869...71,218,902
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 decreases expression ISO Tacrolimus results in decreased expression of HSDL2 mRNA CTD PMID:25270620 NCBI chr 5:76,812,881...76,848,853
Ensembl chr 5:76,812,931...76,848,101
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Tacrolimus results in increased expression of HSPA5 mRNA CTD PMID:25270620 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions
increases expression
EXP Tacrolimus inhibits the reaction [Acrylamide results in decreased expression of HSPA8 protein]
Tacrolimus results in increased expression of HSPA8 protein
CTD PMID:15081597 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
increases expression
EXP
ISO
Tacrolimus results in decreased expression of ICAM1; Tacrolimus results in decreased expression of ICAM1 protein
Tacrolimus results in increased expression of ICAM1 mRNA
CTD PMID:9794552, PMID:10385251, PMID:23958496 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO Tacrolimus results in increased expression of ID1 mRNA CTD PMID:25270620, PMID:29362864 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Tacrolimus results in increased expression of ID2 mRNA CTD PMID:25270620 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Tacrolimus results in increased expression of ID3 mRNA CTD PMID:29362864 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Id4 inhibitor of DNA binding 4, HLH protein increases expression ISO Tacrolimus results in increased expression of ID4 mRNA CTD PMID:25270620 NCBI chr17:16,692,557...16,695,126
Ensembl chr17:16,692,557...16,695,126
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 decreases expression ISO Tacrolimus results in decreased expression of IDI1 mRNA CTD PMID:25270620 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifi27l2b interferon, alpha-inducible protein 27 like 2B increases expression ISO Tacrolimus results in increased expression of IFI27L2A mRNA CTD PMID:29362864 NCBI chr 6:127,336,305...127,337,791
Ensembl chr 6:127,336,305...127,337,791
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
decreases secretion
ISO
EXP
[Tacrolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA; Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IFNG protein]; Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of IFNG protein]; Tacrolimus inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IFNG mRNA]
Tacrolimus results in decreased expression of IFNG protein
Tacrolimus results in decreased expression of IFNG mRNA; Tacrolimus results in decreased expression of IFNG protein
[Tacrolimus co-treated with TAK 779] results in decreased expression of IFNG protein
Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in decreased expression of BCL2 protein]; Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BAX protein]; Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TRP53 protein]
Tacrolimus results in decreased secretion of IFNG protein
CTD PMID:1371491, PMID:8986461, PMID:10205001, PMID:11407316, PMID:11692113, PMID:16368244, PMID:20967261, PMID:21515370, PMID:24603311, PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 increases response to substance EXP IGF1 protein results in increased susceptibility to Tacrolimus CTD PMID:12826230 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression
increases expression
EXP Tacrolimus results in decreased expression of IGFBP1 mRNA
Tacrolimus results in increased expression of IGFBP1 mRNA
CTD PMID:21865292 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 increases expression EXP Tacrolimus results in increased expression of IGFBP5 mRNA CTD PMID:21865292 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Il15ra interleukin 15 receptor subunit alpha increases expression ISO Tacrolimus results in increased expression of IL15RA mRNA CTD PMID:23958496 NCBI chr17:70,451,861...70,481,838
Ensembl chr17:70,451,411...70,481,750
JBrowse link
G Il17ra interleukin 17 receptor A increases expression ISO Tacrolimus results in increased expression of IL17RA mRNA CTD PMID:23958496 NCBI chr 4:152,995,865...153,018,394
Ensembl chr 4:152,995,865...153,018,394
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Tacrolimus results in increased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression ISO Tacrolimus results in increased expression of IL1RN mRNA CTD PMID:23958496 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
ISO
EXP
[Tacrolimus co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL2 protein]; Tacrolimus inhibits the reaction [CD2 protein results in increased expression of IL2 protein]; Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of IL2 protein]; Tacrolimus inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Tacrolimus inhibits the reaction [Zinc Sulfate inhibits the reaction [Mitogens results in increased expression of IL2 mRNA]]
Tacrolimus results in decreased expression of IL2 mRNA; Tacrolimus results in decreased expression of IL2 protein
Tacrolimus affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of IL2 protein]; Tacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]]
CTD PMID:1371491, PMID:1614535, PMID:1701765, PMID:1705513, PMID:8986461, PMID:11407316, PMID:12126653, PMID:16055081, PMID:24603311, PMID:25770929, PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Tacrolimus results in increased expression of IL23A mRNA CTD PMID:25270620 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Tacrolimus results in decreased expression of IL2RA protein CTD PMID:1701765 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il3 interleukin 3 decreases expression
multiple interactions
ISO Tacrolimus results in decreased expression of IL3 protein
Sirolimus inhibits the reaction [Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL3 protein]]; Tacrolimus inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL3 protein]
CTD PMID:1376361, PMID:11407316 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO
EXP
Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL4 protein]
Tacrolimus results in decreased expression of IL4 mRNA; Tacrolimus results in decreased expression of IL4 protein
Tacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [bisphenol A results in increased expression of IL4 protein]; Tacrolimus inhibits the reaction [nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [nonylphenol results in increased expression of IL4 protein]
CTD PMID:1371491, PMID:10685002, PMID:11407316, PMID:12709020, PMID:16368244 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression
ISO Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL5 protein]
Tacrolimus results in decreased expression of IL5 mRNA; Tacrolimus results in decreased expression of IL5 protein
CTD PMID:1371491, PMID:7540862, PMID:11407316, PMID:15948978 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
decreases expression
EXP
ISO
[Tacrolimus co-treated with quinapril] results in decreased expression of IL6 protein; [Tacrolimus co-treated with quinapril] results in increased expression of IL6 protein; [Tacrolimus co-treated with Valsartan] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Valsartan] results in increased expression of IL6 protein
Tacrolimus results in increased expression of IL6 mRNA
parthenolide inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA]; sulforafan inhibits the reaction [Tacrolimus results in increased expression of IL6 mRNA]
Tacrolimus results in increased expression of IL6 protein
Tacrolimus results in decreased expression of IL6 protein
CTD PMID:16549154, PMID:23958496 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Imp4 IMP U3 small nucleolar ribonucleoprotein 4 decreases expression ISO Tacrolimus results in decreased expression of IMP4 mRNA CTD PMID:25270620 NCBI chr 9:37,769,959...37,775,097
Ensembl chr 9:37,769,959...37,775,154
JBrowse link
G Ino80e INO80 complex subunit E decreases expression ISO Tacrolimus results in decreased expression of INO80E mRNA CTD PMID:25270620 NCBI chr 1:198,287,489...198,298,076
Ensembl chr 1:198,287,490...198,298,076
JBrowse link
G Ins2 insulin 2 decreases expression ISO Tacrolimus results in decreased expression of INS protein CTD PMID:17391142 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of IRAK1 protein CTD PMID:23958496 NCBI chr  X:156,716,469...156,726,367
Ensembl chr  X:156,716,604...156,725,977
JBrowse link
G Itgal integrin subunit alpha L decreases expression EXP Tacrolimus results in decreased expression of ITGAL CTD PMID:9794552 NCBI chr 1:198,744,053...198,781,745
Ensembl chr 1:198,744,050...198,781,750
JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of JAK2 protein CTD PMID:23958496 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Tacrolimus results in decreased expression of JUN protein CTD PMID:9674596 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Tacrolimus results in increased expression of JUNB mRNA CTD PMID:23958496 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Kifap3 kinesin-associated protein 3 decreases expression EXP Tacrolimus results in decreased expression of KIFAP3 mRNA CTD PMID:21865292 NCBI chr13:82,072,497...82,217,256
Ensembl chr13:82,072,497...82,217,252
JBrowse link
G Kifc1 kinesin family member C1 decreases expression EXP Tacrolimus results in decreased expression of KIFC1 mRNA CTD PMID:21865292 NCBI chr20:5,509,059...5,526,175
Ensembl chr20:5,509,059...5,526,175
JBrowse link
G Klf5 Kruppel-like factor 5 increases expression EXP Tacrolimus results in increased expression of KLF5 mRNA CTD PMID:21865292 NCBI chr15:83,703,796...83,722,921
Ensembl chr15:83,703,791...83,722,921
JBrowse link
G Klf6 Kruppel-like factor 6 increases expression EXP Tacrolimus results in increased expression of KLF6 mRNA CTD PMID:21865292 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Klk1c10 kallikrein 1-related peptidase C10 increases expression EXP Tacrolimus results in increased expression of KLK1C10 mRNA CTD PMID:21865292 NCBI chr 1:99,890,294...99,894,353
Ensembl chr 1:99,890,294...99,894,353
JBrowse link
G Klk1c9 kallikrein 1-related peptidase C9 increases expression EXP Tacrolimus results in increased expression of KLK1C9 mRNA CTD PMID:21865292 NCBI chr 1:100,086,520...100,090,406
Ensembl chr 1:100,059,967...100,203,329
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases expression ISO Tacrolimus results in increased expression of KRAS mRNA CTD PMID:25270620 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt20 keratin 20 increases expression ISO Tacrolimus results in increased expression of KRT20 mRNA CTD PMID:29362864 NCBI chr10:87,342,514...87,351,045
Ensembl chr10:87,342,619...87,351,045
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression EXP Tacrolimus results in increased expression of LAMC2 mRNA CTD PMID:21865292 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Tacrolimus results in increased expression of LBP mRNA CTD PMID:21865292 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP
ISO
Tacrolimus results in increased expression of LCN2 mRNA CTD PMID:21865292, PMID:29362864 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Lias lipoic acid synthetase decreases expression ISO Tacrolimus results in decreased expression of LIAS mRNA CTD PMID:21621594 NCBI chr14:44,507,217...44,524,287
Ensembl chr14:44,507,218...44,524,252
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Tacrolimus results in increased expression of LIF mRNA CTD PMID:23958496 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Limk1 LIM domain kinase 1 increases expression ISO Tacrolimus results in increased expression of LIMK1 mRNA CTD PMID:29380240 NCBI chr12:25,036,630...25,070,538
Ensembl chr12:25,036,605...25,070,539
JBrowse link
G Llgl1 LLGL scribble cell polarity complex component 1 increases expression ISO Tacrolimus results in increased expression of LLGL1 mRNA CTD PMID:29380240 NCBI chr10:46,940,873...46,955,524
Ensembl chr10:46,940,965...46,954,674
JBrowse link
G LOC103692166 WD repeat-containing protein 54 decreases expression ISO Tacrolimus results in decreased expression of WDR54 mRNA CTD PMID:25270620 NCBI chr 4:113,984,754...113,988,487
Ensembl chr 4:114,850,815...114,853,868
Ensembl chr 4:114,850,815...114,853,868
JBrowse link
G Lta lymphotoxin alpha multiple interactions ISO Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of LTA protein] CTD PMID:1371491 NCBI chr20:4,851,889...4,854,677
Ensembl chr20:4,852,496...4,854,677
JBrowse link
G Ltf lactotransferrin increases expression ISO Tacrolimus results in increased expression of LTF mRNA CTD PMID:21621594 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Ly86 lymphocyte antigen 86 increases expression ISO Tacrolimus results in increased expression of LY86 mRNA CTD PMID:29362864 NCBI chr17:28,104,535...28,191,447
Ensembl chr17:28,104,589...28,191,436
JBrowse link
G Lyve1 lymphatic vessel endothelial hyaluronan receptor 1 decreases expression ISO Tacrolimus results in decreased expression of LYVE1 mRNA CTD PMID:25270620 NCBI chr 1:175,663,266...175,676,699
Ensembl chr 1:175,663,266...175,676,699
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Tacrolimus results in increased expression of MAFF mRNA CTD PMID:23958496 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Mafk MAF bZIP transcription factor K increases expression ISO Tacrolimus results in increased expression of MAFK mRNA CTD PMID:23958496 NCBI chr12:16,923,989...16,934,706
Ensembl chr12:16,923,990...16,934,706
JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor increases expression ISO Tacrolimus results in increased expression of MANF mRNA CTD PMID:25270620 NCBI chr 8:115,623,175...115,626,408
Ensembl chr 8:115,623,178...115,626,380
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of MAP3K7 protein CTD PMID:23958496 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases activity
multiple interactions
EXP Tacrolimus results in decreased activity of MAPK8 protein
Tacrolimus inhibits the reaction [Oxygen deficiency results in increased activity of MAPK8 protein]
CTD PMID:12892836 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 decreases expression ISO Tacrolimus results in decreased expression of MBNL2 mRNA CTD PMID:25270620 NCBI chr15:105,640,097...105,797,933
Ensembl chr15:105,640,097...105,797,932
JBrowse link
G Mcam melanoma cell adhesion molecule decreases expression ISO Tacrolimus results in decreased expression of MCAM mRNA CTD PMID:25270620 NCBI chr 8:48,472,824...48,481,005
Ensembl chr 8:48,472,824...48,481,001
JBrowse link
G Mcrs1 microspherule protein 1 decreases expression ISO Tacrolimus results in decreased expression of MCRS1 mRNA CTD PMID:25270620 NCBI chr 7:140,910,420...140,919,234
Ensembl chr 7:140,910,423...140,919,234
JBrowse link
G Memo1 mediator of cell motility 1 decreases expression ISO Tacrolimus results in decreased expression of MEMO1 mRNA CTD PMID:25270620 NCBI chr 6:22,362,483...22,409,583
Ensembl chr 6:22,362,484...22,409,579
JBrowse link
G Mettl1 methyltransferase like 1 increases expression ISO Tacrolimus results in increased expression of METTL1 mRNA CTD PMID:25270620 NCBI chr 7:70,328,470...70,333,045
Ensembl chr 7:70,328,391...70,333,166
JBrowse link
G Mfsd1 major facilitator superfamily domain containing 1 increases expression ISO Tacrolimus results in increased expression of MFSD1 mRNA CTD PMID:25270620 NCBI chr 2:164,747,655...164,767,682
Ensembl chr 2:164,747,677...164,767,682
JBrowse link
G Mgll monoglyceride lipase decreases expression ISO Tacrolimus results in decreased expression of MGLL mRNA CTD PMID:25270620 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Mir146a microRNA 146a increases expression ISO Tacrolimus results in increased expression of MIR146 mRNA CTD PMID:29362864 NCBI chr10:28,962,476...28,962,570
Ensembl chr10:28,962,476...28,962,570
JBrowse link
G Mir146b microRNA 146b increases expression ISO Tacrolimus results in increased expression of MIR146B mRNA CTD PMID:29362864 NCBI chr 1:266,089,488...266,089,575
Ensembl chr 1:266,089,488...266,089,575
JBrowse link
G Mir193a microRNA 193a decreases expression ISO Tacrolimus results in decreased expression of MIR193A mRNA CTD PMID:29362864 NCBI chr10:67,065,885...67,065,996
Ensembl chr10:67,065,885...67,065,996
JBrowse link
G Mir200b microRNA 200b decreases expression ISO Tacrolimus results in decreased expression of MIR200B mRNA CTD PMID:29362864 NCBI chr 5:173,490,144...173,490,238
Ensembl chr 5:173,490,144...173,490,238
JBrowse link
G Mir21 microRNA 21 increases expression ISO Tacrolimus results in increased expression of MIR21A mRNA CTD PMID:29362864 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir34b microRNA 34b increases expression ISO Tacrolimus results in increased expression of MIR34B mRNA CTD PMID:29362864 NCBI chr 8:55,492,542...55,492,625
Ensembl chr 8:55,492,542...55,492,625
JBrowse link
G Mir551b microRNA 551b decreases expression ISO Tacrolimus results in decreased expression of MIR551B mRNA CTD PMID:29362864 NCBI chr 2:116,867,647...116,867,744
Ensembl chr 2:116,867,647...116,867,744
JBrowse link
G Mob4 MOB family member 4, phocein increases expression ISO Tacrolimus results in increased expression of MOB4 mRNA CTD PMID:25270620 NCBI chr 9:61,720,583...61,744,532
Ensembl chr 9:61,720,583...61,744,531
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression
EXP Tacrolimus inhibits the reaction [Indomethacin results in increased activity of MPO protein]
Tacrolimus results in decreased expression of MPO protein
CTD PMID:9655420, PMID:17202747 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrm3 mitochondrial rRNA methyltransferase 3 decreases expression ISO Tacrolimus results in decreased expression of MRM3 mRNA CTD PMID:25270620 NCBI chr10:64,398,308...64,406,193
Ensembl chr10:64,398,339...64,405,017
JBrowse link
G Ms4a6e membrane spanning 4-domains A6E increases expression ISO Tacrolimus results in increased expression of MS4A6C mRNA CTD PMID:29362864 NCBI chr 1:227,757,444...227,769,336
Ensembl chr 1:227,757,425...227,818,305
Ensembl chr 1:227,757,425...227,818,305
JBrowse link
G Msln mesothelin increases expression ISO Tacrolimus results in increased expression of MSLN mRNA CTD PMID:29362864 NCBI chr10:15,119,700...15,129,129
Ensembl chr10:15,119,663...15,125,408
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP
ISO
Tacrolimus results in increased expression of MYC mRNA CTD PMID:21865292, PMID:23958496 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Naaa N-acylethanolamine acid amidase increases expression ISO Tacrolimus results in increased expression of NAAA mRNA CTD PMID:29362864 NCBI chr14:17,283,262...17,302,364
Ensembl chr14:17,283,124...17,302,366
JBrowse link
G Nckap1l NCK associated protein 1 like increases expression ISO Tacrolimus results in increased expression of NCKAP1L mRNA CTD PMID:29362864 NCBI chr 7:145,068,239...145,113,507
Ensembl chr 7:145,068,286...145,113,507
JBrowse link
G Ncr3 natural cytotoxicity triggering receptor 3 increases expression ISO Tacrolimus results in increased expression of NCR3 CTD PMID:20736080 NCBI chr20:5,170,169...5,175,773
Ensembl chr20:5,170,215...5,175,773
JBrowse link
G Ndrg1 N-myc downstream regulated 1 increases expression ISO Tacrolimus results in increased expression of NDRG1 mRNA CTD PMID:25270620 NCBI chr 7:107,734,326...107,775,701
Ensembl chr 7:107,734,323...107,775,714
JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 multiple interactions ISO Tacrolimus inhibits the reaction [bisphenol A promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [nonylphenol promotes the reaction [NFATC3 protein binds to IL4 promoter]]; Tacrolimus inhibits the reaction [Thapsigargin affects the localization of and results in increased activity of NFATC3 protein] CTD PMID:10339586, PMID:12709020 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003
JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 multiple interactions ISO
EXP
Tacrolimus inhibits the reaction [20-hydroxy-5,8,11,14-eicosatetraenoic acid results in increased localization of NFATC4 protein]; Tacrolimus inhibits the reaction [Phenylephrine results in increased localization of NFATC4 protein] CTD PMID:16055480 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO Tacrolimus results in increased expression of NFE2L2 protein CTD PMID:23958496 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
increases expression
ISO Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFKB1 protein]
Tacrolimus results in increased expression of NFKB1 mRNA
CTD PMID:18172213, PMID:18172886, PMID:23958496 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 increases expression ISO Tacrolimus results in increased expression of NFKB2 mRNA CTD PMID:23958496 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nfkbia NFKB inhibitor alpha decreases degradation
increases phosphorylation
multiple interactions
ISO Tacrolimus results in decreased degradation of NFKBIA protein
Tacrolimus results in increased phosphorylation of NFKBIA protein
ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Tacrolimus results in increased phosphorylation of NFKBIA protein]
CTD PMID:16181452, PMID:23958496 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NFKBIB protein] CTD PMID:18172213, PMID:18172886 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
JBrowse link
G Nfkbie NFKB inhibitor epsilon increases expression ISO Tacrolimus results in increased expression of NFKBIE mRNA CTD PMID:23958496 NCBI chr 9:17,828,405...17,835,240
Ensembl chr 9:17,828,408...17,835,240
JBrowse link
G Ngf nerve growth factor multiple interactions EXP NGF protein inhibits the reaction [Tacrolimus results in increased activity of CASP3 protein]; Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 mRNA]; Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 protein] CTD PMID:17385075, PMID:23825664 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Nol8 nucleolar protein 8 increases expression ISO Tacrolimus results in increased expression of NOL8 mRNA CTD PMID:25270620 NCBI chr17:14,565,794...14,589,154
Ensembl chr17:14,565,794...14,589,154
Ensembl chr17:14,565,794...14,589,154
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS1 protein] CTD PMID:20149694 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Tacrolimus inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
Tacrolimus inhibits the reaction [[Lithium co-treated with Pilocarpine] results in increased expression of NOS2 protein]; Tacrolimus inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]
CTD PMID:12144947, PMID:17202747, PMID:20149694 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
decreases expression
decreases activity
ISO
EXP
Tacrolimus results in increased expression of NOS3 mRNA
Tacrolimus results in decreased expression of NOS3 mRNA
Tacrolimus results in decreased activity of NOS3 protein
CTD PMID:9931093, PMID:12352326 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nox1 NADPH oxidase 1 increases expression EXP Tacrolimus results in increased expression of NOX1 mRNA CTD PMID:17085464 NCBI chr  X:104,909,328...104,932,508
Ensembl chr  X:104,909,326...104,932,508
JBrowse link
G Nppa natriuretic peptide A multiple interactions ISO Tacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPA mRNA] CTD PMID:15939815 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nppb natriuretic peptide B multiple interactions ISO Tacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPB mRNA] CTD PMID:15939815 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Npr1 natriuretic peptide receptor 1 multiple interactions ISO Tacrolimus inhibits the reaction [NPR1 protein affects the expression of FN1 mRNA]; Tacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPA mRNA]; Tacrolimus inhibits the reaction [NPR1 protein affects the expression of NPPB mRNA] CTD PMID:15939815 NCBI chr 2:189,840,403...189,857,032
Ensembl chr 2:189,840,403...189,856,090
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions
increases activity
ISO Tacrolimus inhibits the reaction [NR3C1 protein binds to FKBP5 protein]; Tacrolimus promotes the reaction [Dexamethasone binds to NR3C1 protein]; Tacrolimus promotes the reaction [NR3C1 protein binds to PPP5C protein]
Tacrolimus results in increased activity of NR3C1 protein
CTD PMID:15697228 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Ogn osteoglycin increases expression EXP
ISO
Tacrolimus results in increased expression of OGN mRNA CTD PMID:21865292, PMID:29362864 NCBI chr17:14,607,442...14,628,274
Ensembl chr17:15,447,716...15,467,359
Ensembl chr17:15,447,716...15,467,359
JBrowse link
G Olfml3 olfactomedin-like 3 increases expression ISO Tacrolimus results in increased expression of OLFML3 mRNA CTD PMID:29362864 NCBI chr 2:206,219,419...206,222,248
Ensembl chr 2:206,219,419...206,222,248
JBrowse link
G Panx1 Pannexin 1 increases expression ISO Tacrolimus results in increased expression of PANX1 mRNA CTD PMID:29362864 NCBI chr 8:13,567,185...13,606,040
Ensembl chr 8:13,566,739...13,606,040
JBrowse link
G Pbk PDZ binding kinase increases expression ISO Tacrolimus results in increased expression of PBK mRNA CTD PMID:29362864 NCBI chr15:42,489,253...42,500,377
Ensembl chr15:42,489,377...42,500,395
JBrowse link
G Pcbp4 poly(rC) binding protein 4 decreases expression ISO Tacrolimus results in decreased expression of PCBP4 mRNA CTD PMID:25270620 NCBI chr 8:115,154,848...115,165,706
Ensembl chr 8:115,155,470...115,165,706
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Tacrolimus affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein]; Tacrolimus affects the reaction [Tacrolimus affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein]] CTD PMID:25770929 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcolce procollagen C-endopeptidase enhancer decreases expression ISO Tacrolimus results in decreased expression of PCOLCE mRNA CTD PMID:25270620 NCBI chr12:22,153,995...22,160,311
Ensembl chr12:22,153,983...22,160,337
JBrowse link
G Pdcd2 programmed cell death 2 increases expression ISO Tacrolimus results in increased expression of PDCD2 mRNA CTD PMID:25270620 NCBI chr 1:57,512,968...57,518,458
Ensembl chr 1:57,512,968...57,518,458
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha increases expression ISO Tacrolimus results in increased expression of PDGFRA mRNA CTD PMID:29362864 NCBI chr14:35,527,926...35,581,130
Ensembl chr14:35,527,927...35,581,031
JBrowse link
G Pdia4 protein disulfide isomerase family A, member 4 increases expression ISO Tacrolimus results in increased expression of PDIA4 mRNA CTD PMID:25270620 NCBI chr 4:77,470,636...77,489,535
Ensembl chr 4:77,470,636...77,489,535
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 increases expression ISO Tacrolimus results in increased expression of PDIA6 mRNA CTD PMID:25270620 NCBI chr 6:42,568,269...42,585,654
Ensembl chr 6:42,568,220...42,585,652
JBrowse link
G Phlda1 pleckstrin homology-like domain, family A, member 1 increases expression ISO Tacrolimus results in increased expression of PHLDA1 mRNA CTD PMID:23958496 NCBI chr 7:54,247,460...54,249,664
Ensembl chr 7:54,247,460...54,249,664
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Tacrolimus results in increased expression of PID1 mRNA CTD PMID:29362864 NCBI chr 9:91,667,748...91,683,468
Ensembl chr 9:91,665,986...91,882,927
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO PINK1 protein affects the reaction [Tacrolimus results in increased phosphorylation of DNM1L protein] CTD PMID:19492085 NCBI chr 5:156,677,146...156,689,258
Ensembl chr 5:156,677,146...156,689,415
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 increases expression ISO Tacrolimus results in increased expression of PKMYT1 mRNA CTD PMID:29362864 NCBI chr10:13,061,077...13,072,277
Ensembl chr10:13,061,170...13,073,283
JBrowse link
G Pkp4 plakophilin 4 decreases expression EXP Tacrolimus results in decreased expression of PKP4 mRNA CTD PMID:21865292 NCBI chr 3:45,211,097...45,414,524
Ensembl chr 3:45,277,348...45,414,613
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression ISO Tacrolimus results in increased expression of PLA2G12A mRNA CTD PMID:25270620 NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972
JBrowse link
G Plat plasminogen activator, tissue type decreases expression ISO Tacrolimus results in decreased expression of PLAT mRNA CTD PMID:25270620 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plbd2 phospholipase B domain containing 2 decreases expression ISO Tacrolimus results in decreased expression of PLBD2 mRNA CTD PMID:25270620 NCBI chr12:41,600,005...41,619,779
Ensembl chr12:41,600,005...41,619,186
JBrowse link
G Por cytochrome p450 oxidoreductase affects response to substance ISO POR polymorphism affects the susceptibility to Tacrolimus CTD PMID:24113216 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha affects response to substance ISO PPARA polymorphism affects the susceptibility to Tacrolimus CTD PMID:24113216 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO [Sirolimus co-treated with Tacrolimus] results in increased expression of PPARG protein CTD PMID:17016853 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppl periplakin increases expression EXP Tacrolimus results in increased expression of PPL mRNA CTD PMID:21865292 NCBI chr10:10,644,572...10,690,223
Ensembl chr10:10,644,572...10,690,223
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression ISO Tacrolimus results in increased expression of PPP1R15A mRNA CTD PMID:23958496 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha multiple interactions
decreases activity
ISO [Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin CTD PMID:10898953, PMID:19553475 NCBI chr 2:241,909,332...242,186,861
Ensembl chr 2:241,909,832...242,184,854
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit multiple interactions ISO Tacrolimus promotes the reaction [NR3C1 protein binds to PPP5C protein] CTD PMID:15697228 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
JBrowse link
G Prcp prolylcarboxypeptidase increases expression EXP Tacrolimus results in increased expression of PRCP mRNA CTD PMID:21865292 NCBI chr 1:157,701,089...157,750,177
Ensembl chr 1:157,701,089...157,750,169
JBrowse link
G Prlr prolactin receptor decreases expression EXP Tacrolimus results in decreased expression of PRLR mRNA CTD PMID:21865292 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Psmb10 proteasome 20S subunit beta 10 increases expression ISO Tacrolimus results in increased expression of PSMB10 mRNA CTD PMID:29362864 NCBI chr19:37,909,543...37,912,027
Ensembl chr19:37,909,546...37,912,027
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO Tacrolimus inhibits the reaction [bisperoxovanadium results in increased expression of PTGS2 mRNA]
Tacrolimus results in increased expression of PTGS2 mRNA
CTD PMID:12493747, PMID:23958496 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 decreases activity ISO Tacrolimus results in decreased activity of PTPN5 protein CTD PMID:17360923 NCBI chr 1:103,197,918...103,258,309
Ensembl chr 1:103,197,915...103,256,823
JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 increases expression EXP Tacrolimus results in increased expression of PTPRZ1 mRNA CTD PMID:21865292 NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
JBrowse link
G Rab4a RAB4A, member RAS oncogene family increases expression ISO Tacrolimus results in increased expression of RAB4A mRNA CTD PMID:29380240 NCBI chr19:56,585,598...56,613,078
Ensembl chr19:56,585,767...56,613,075
JBrowse link
G Rac1 Rac family small GTPase 1 increases expression EXP Tacrolimus results in increased expression of RAC1 mRNA CTD PMID:17085464 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Ramp1 receptor activity modifying protein 1 increases expression ISO Tacrolimus results in increased expression of RAMP1 mRNA CTD PMID:29362864 NCBI chr 9:98,313,632...98,364,206
Ensembl chr 9:98,313,632...98,364,205
JBrowse link
G Rcc1 regulator of chromosome condensation 1 decreases expression ISO Tacrolimus results in decreased expression of RCC1 mRNA CTD PMID:25270620 NCBI chr 5:150,508,840...150,531,062
Ensembl chr 5:150,509,040...150,525,254
JBrowse link
G Rcor2 REST corepressor 2 decreases expression ISO Tacrolimus results in decreased expression of RCOR2 mRNA CTD PMID:25270620 NCBI chr 1:222,513,970...222,525,356
Ensembl chr 1:222,519,615...222,524,779
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of REL protein] CTD PMID:18172213 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Tacrolimus co-treated with Thapsigargin] affects the localization of and results in increased activity of RELA protein; Tacrolimus affects the localization of and results in increased activity of RELA protein; Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of RELA protein]; Tacrolimus results in increased phosphorylation of and affects the localization of RELA protein CTD PMID:10339586, PMID:18172886, PMID:23958496 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit increases expression ISO Tacrolimus results in increased expression of RELB mRNA CTD PMID:23958496 NCBI chr 1:80,517,081...80,545,019
Ensembl chr 1:80,517,411...80,544,825
JBrowse link
G Ren renin multiple interactions
increases expression
decreases activity
EXP nilvadipine inhibits the reaction [Tacrolimus results in increased expression of REN protein]
Tacrolimus results in increased expression of REN mRNA; Tacrolimus results in increased expression of REN protein
Tacrolimus results in decreased activity of REN protein
CTD PMID:7509514, PMID:7532090, PMID:7533848, PMID:12469222, PMID:21865292 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Renbp renin binding protein increases expression ISO Tacrolimus results in increased expression of RENBP mRNA CTD PMID:25270620 NCBI chr  X:156,854,490...156,863,548
Ensembl chr  X:156,854,594...156,863,528
JBrowse link
G Rgn regucalcin decreases expression EXP Tacrolimus results in decreased expression of RGN mRNA CTD PMID:21865292 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
G Rgs16 regulator of G-protein signaling 16 increases expression ISO Tacrolimus results in increased expression of RGS16 mRNA CTD PMID:29362864 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
JBrowse link
G Rhebl1 RHEB like 1 increases expression ISO Tacrolimus results in increased expression of RHEBL1 mRNA CTD PMID:23958496 NCBI chr 7:140,552,704...140,556,980
Ensembl chr 7:140,552,733...140,556,639
JBrowse link
G Rhou ras homolog family member U increases expression ISO Tacrolimus results in increased expression of RHOU mRNA CTD PMID:29362864 NCBI chr19:56,431,787...56,443,896
Ensembl chr19:56,435,577...56,441,733
JBrowse link
G Rnase2 ribonuclease A family member 2 increases expression ISO Tacrolimus results in increased expression of RNASE2A mRNA CTD PMID:29362864 NCBI chr15:28,154,482...28,155,291
Ensembl chr15:28,154,482...28,155,291
JBrowse link
G Rnase3 ribonuclease A family member 3 increases expression ISO Tacrolimus results in increased expression of EAR1 mRNA CTD PMID:29362864 NCBI chr15:28,216,744...28,217,614
Ensembl chr15:28,216,744...28,217,614
JBrowse link
G Rpn1 ribophorin I increases expression ISO Tacrolimus results in increased expression of RPN1 mRNA CTD PMID:25270620 NCBI chr 4:119,997,232...120,018,687
Ensembl chr 4:119,997,268...120,018,679
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO Tacrolimus inhibits the reaction [Sirolimus inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]] CTD PMID:1614535 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rrp9 ribosomal RNA processing 9, U3 small nucleolar RNA binding protein decreases expression ISO Tacrolimus results in decreased expression of RRP9 mRNA CTD PMID:25270620 NCBI chr 8:115,179,899...115,188,551
Ensembl chr 8:115,179,893...115,188,588
JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression EXP Tacrolimus results in decreased expression of RUNX2 mRNA CTD PMID:15780950 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Ryr1 ryanodine receptor 1 multiple interactions ISO Tacrolimus inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of RYR1 protein] CTD PMID:18172213, PMID:18172886 NCBI chr 1:87,959,596...88,066,252
Ensembl chr 1:87,959,712...88,066,101
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO Tacrolimus results in increased expression of S100A6 mRNA CTD PMID:29362864 NCBI chr 2:190,007,013...190,008,512
Ensembl chr 2:190,007,216...190,008,511
JBrowse link
G Sct secretin increases expression ISO Tacrolimus results in increased expression of SCT mRNA CTD PMID:29362864 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression ISO Tacrolimus results in increased expression of SDF2L1 mRNA CTD PMID:25270620 NCBI chr11:88,122,271...88,124,513
Ensembl chr11:88,122,271...88,124,513
JBrowse link
G Seh1l SEH1-like nucleoporin increases expression ISO Tacrolimus results in increased expression of SEH1L mRNA CTD PMID:25270620 NCBI chr18:63,545,150...63,568,101 JBrowse link
G Sele selectin E increases expression EXP Tacrolimus results in increased expression of SELE mRNA CTD PMID:21865292 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Selenos selenoprotein S increases expression ISO Tacrolimus results in increased expression of SELENOS mRNA CTD PMID:25270620 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Serinc3 serine incorporator 3 decreases expression ISO Tacrolimus results in decreased expression of SERINC3 mRNA CTD PMID:21621594 NCBI chr 3:160,018,643...160,038,078
Ensembl chr 3:160,018,646...160,038,078
JBrowse link
G Serp1 stress-associated endoplasmic reticulum protein 1 increases expression ISO Tacrolimus results in increased expression of SERP1 mRNA CTD PMID:25270620 NCBI chr 2:148,718,279...148,722,263
Ensembl chr 2:148,718,280...148,722,263
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N increases expression EXP Tacrolimus results in increased expression of SERPINA3N mRNA CTD PMID:21865292 NCBI chr 6:128,073,344...128,080,878
Ensembl chr 6:127,941,526...128,080,889
JBrowse link
G Serpinb9 serpin family B member 9 increases expression ISO Tacrolimus results in increased expression of SERPINB9 mRNA CTD PMID:23958496 NCBI chr17:32,648,846...32,673,047
Ensembl chr17:32,650,441...32,661,865
JBrowse link
G Serpine1 serpin family E member 1 increases expression
multiple interactions
EXP Tacrolimus results in increased expression of SERPINE1 mRNA
Tacrolimus inhibits the reaction [Mercuric Chloride results in increased expression of SERPINE1 protein]; Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 mRNA]; Tacrolimus inhibits the reaction [NGF protein results in increased expression of SERPINE1 protein]
CTD PMID:9422427, PMID:14620542, PMID:21865292, PMID:23825664 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sgo1 shugoshin 1 increases expression ISO Tacrolimus results in increased expression of SGO1 mRNA CTD PMID:29362864 NCBI chr 9:4,420,158...4,435,939
Ensembl chr 9:4,421,069...4,436,601
JBrowse link
G Shf Src homology 2 domain containing F decreases expression ISO Tacrolimus results in decreased expression of SHF mRNA CTD PMID:25270620 NCBI chr 3:114,288,021...114,307,334
Ensembl chr 3:114,287,718...114,307,250
JBrowse link
G Sla src-like adaptor increases expression ISO Tacrolimus results in increased expression of SLA mRNA CTD PMID:29362864 NCBI chr 7:107,585,055...107,604,950
Ensembl chr 7:107,584,118...107,634,335
JBrowse link
G Slc12a3 solute carrier family 12 member 3 affects response to substance
decreases expression
increases phosphorylation
ISO
EXP
SLC12A3 protein affects the susceptibility to Tacrolimus
Tacrolimus results in decreased expression of SLC12A3 mRNA; Tacrolimus results in decreased expression of SLC12A3 protein
Tacrolimus results in increased phosphorylation of SLC12A3 protein
CTD PMID:21865292, PMID:21963515 NCBI chr19:11,106,033...11,144,674
Ensembl chr19:11,106,033...11,144,641
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression EXP Tacrolimus results in decreased expression of SLC16A1 mRNA CTD PMID:21865292 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc22a13 solute carrier family 22 member 13 decreases expression EXP Tacrolimus results in decreased expression of SLC22A13 mRNA CTD PMID:21865292 NCBI chr 8:127,885,268...127,900,829
Ensembl chr 8:127,885,268...127,900,463
JBrowse link
G Slc25a25 solute carrier family 25 member 25 decreases expression EXP Tacrolimus results in decreased expression of SLC25A25 mRNA CTD PMID:21865292 NCBI chr 3:11,442,396...11,476,186
Ensembl chr 3:11,442,397...11,452,529
JBrowse link
G Slc34a2 solute carrier family 34 member 2 increases expression EXP Tacrolimus results in increased expression of SLC34A2 mRNA CTD PMID:21865292 NCBI chr14:60,257,211...60,276,516
Ensembl chr14:60,256,712...60,276,794
JBrowse link
G Smad7 SMAD family member 7 multiple interactions ISO Tacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]]; Tacrolimus inhibits the reaction [SMAD7 protein binds to SMURF1 protein] CTD PMID:16720724 NCBI chr18:71,395,830...71,424,164
Ensembl chr18:71,395,830...71,424,157
JBrowse link
G Smim14 small integral membrane protein 14 increases expression ISO Tacrolimus results in increased expression of SMIM14 mRNA CTD PMID:25270620 NCBI chr14:44,413,636...44,460,044
Ensembl chr14:44,413,636...44,457,239
JBrowse link
G Smurf1 SMAD specific E3 ubiquitin protein ligase 1 multiple interactions ISO Tacrolimus inhibits the reaction [FKBP1A protein promotes the reaction [SMURF1 protein binds to SMAD7 protein binds to ACVR1B protein]]; Tacrolimus inhibits the reaction [SMAD7 protein binds to SMURF1 protein] CTD PMID:16720724 NCBI chr12:11,433,815...11,526,465
Ensembl chr12:11,407,213...11,526,465
JBrowse link
G Snai1 snail family transcriptional repressor 1 increases expression
multiple interactions
ISO Tacrolimus results in increased expression of SNAI1 protein
[GSK3A protein co-treated with GSK3B protein] affects the reaction [Tacrolimus results in increased expression of SNAI1 protein]
CTD PMID:22416070 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Snai2 snail family transcriptional repressor 2 increases expression ISO Tacrolimus results in increased expression of SNAI2 mRNA CTD PMID:22416070 NCBI chr11:90,404,421...90,406,730
Ensembl chr11:90,403,333...90,406,797
JBrowse link
G Sod2 superoxide dismutase 2 increases response to substance
decreases expression
multiple interactions
ISO
EXP
SOD2 protein results in increased susceptibility to Tacrolimus
Tacrolimus results in decreased expression of SOD2 protein
MK0626 inhibits the reaction [Tacrolimus results in decreased expression of SOD2 protein]
CTD PMID:14675044, PMID:24959755 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox9 SRY-box transcription factor 9 increases expression ISO Tacrolimus results in increased expression of SOX9 mRNA CTD PMID:29362864 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Sp7 Sp7 transcription factor decreases expression EXP Tacrolimus results in decreased expression of SP7 mRNA CTD PMID:15780950 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Spaca7 sperm acrosome associated 7 increases expression ISO Tacrolimus results in increased expression of SPACA7 mRNA CTD PMID:29362864 NCBI chr16:82,261,120...82,288,091
Ensembl chr16:82,262,673...82,288,022
JBrowse link
G Spcs2 signal peptidase complex subunit 2 increases expression ISO Tacrolimus results in increased expression of SPCS2 mRNA CTD PMID:25270620 NCBI chr 1:164,829,896...164,849,749
Ensembl chr 1:164,829,896...164,849,749
JBrowse link
G Sphk2 sphingosine kinase 2 decreases expression ISO Tacrolimus results in decreased expression of SPHK2 mRNA CTD PMID:25270620 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Spic Spi-C transcription factor increases expression ISO Tacrolimus results in increased expression of SPIC mRNA CTD PMID:29362864 NCBI chr 7:29,225,721...29,233,452
Ensembl chr 7:29,225,727...29,233,392
JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Tacrolimus results in increased expression of SPP1 mRNA CTD PMID:12472797, PMID:21865292 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Sqor sulfide quinone oxidoreductase decreases expression ISO Tacrolimus results in decreased expression of SQOR mRNA CTD PMID:25270620 NCBI chr 3:114,894,944...114,939,375
Ensembl chr 3:114,900,343...114,939,370
JBrowse link
G Ssr3 signal sequence receptor subunit 3 increases expression ISO Tacrolimus results in increased expression of SSR3 mRNA CTD PMID:25270620 NCBI chr 2:156,010,997...156,023,853
Ensembl chr 2:156,011,002...156,014,527
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 decreases expression ISO Tacrolimus results in decreased expression of STARD4 mRNA CTD PMID:25270620 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of STAT3 protein CTD PMID:23958496 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Tada3 transcriptional adaptor 3 decreases expression ISO Tacrolimus results in decreased expression of TADA3 mRNA CTD PMID:25270620 NCBI chr 4:145,318,417...145,330,291
Ensembl chr 4:145,318,435...145,329,878
JBrowse link
G Tamalin trafficking regulator and scaffold protein tamalin increases expression ISO Tacrolimus results in increased expression of GRASP mRNA CTD PMID:25270620 NCBI chr 7:142,869,785...142,877,551
Ensembl chr 7:142,869,752...142,878,347
JBrowse link
G Tatdn1 TatD DNase domain containing 1 increases expression ISO Tacrolimus results in increased expression of TATDN1 mRNA CTD PMID:25270620 NCBI chr 7:98,782,164...98,813,001
Ensembl chr 7:98,782,178...98,804,499
JBrowse link
G Tekt1 tektin 1 increases expression EXP Tacrolimus results in increased expression of TEKT1 mRNA CTD PMID:21865292 NCBI chr10:58,895,689...58,924,098
Ensembl chr10:58,895,674...58,924,137
JBrowse link
G Tfrc transferrin receptor decreases expression ISO Tacrolimus results in decreased expression of TFRC protein CTD PMID:1701765 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
increases expression
decreases expression
ISO
EXP
Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 mRNA]
Tacrolimus results in increased expression of TGFB1 mRNA; Tacrolimus results in increased expression of TGFB1 protein
Tacrolimus results in decreased expression of TGFB1 mRNA
[Tacrolimus co-treated with Quinapril] results in increased expression of TGFB1 protein; [Tacrolimus co-treated with Valsartan] results in increased expression of TGFB1 protein; pyrrolidine dithiocarbamic acid inhibits the reaction [Tacrolimus results in increased expression of TGFB1 mRNA]; Ramipril inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]; Tacrolimus inhibits the reaction [Mercuric Chloride results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
CTD PMID:9422427, PMID:11091246, PMID:12352326, PMID:12472797, PMID:14620542, PMID:15854665, PMID:16549154, PMID:16980036, PMID:17085464, PMID:17703430, PMID:18342291 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbi transforming growth factor, beta induced increases expression ISO Tacrolimus results in increased expression of TGFBI mRNA CTD PMID:29362864 NCBI chr17:8,400,123...8,429,338
Ensembl chr17:8,400,146...8,429,338
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 increases expression EXP Tacrolimus results in increased expression of TGFBR1 mRNA; Tacrolimus results in increased expression of TGFBR1 protein CTD PMID:16980036 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP Tacrolimus results in increased expression of TGFBR2 mRNA; Tacrolimus results in increased expression of TGFBR2 protein CTD PMID:16980036 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Tgm1 transglutaminase 1 increases expression EXP Tacrolimus results in increased expression of TGM1 mRNA CTD PMID:21865292 NCBI chr15:34,378,136...34,393,150
Ensembl chr15:34,378,148...34,392,066
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
increases expression
EXP pirfenidone promotes the reaction [Tacrolimus results in decreased expression of TIMP1 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Tacrolimus results in increased expression of TIMP1 mRNA] CTD PMID:11091246, PMID:12472797, PMID:15854665, PMID:21865292 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr2 toll-like receptor 2 increases expression ISO Tacrolimus results in increased expression of TLR2 mRNA CTD PMID:29362864 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tmem202 transmembrane protein 202 decreases expression ISO Tacrolimus results in decreased expression of TMEM202 mRNA CTD PMID:25270620 NCBI chr 8:64,299,646...64,305,330
Ensembl chr 8:64,299,646...64,305,330
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
decreases expression
decreases secretion
ISO
EXP
Tacrolimus inhibits the reaction [[N-Formylmethionine Leucyl-Phenylalanine co-treated with TNF protein] results in increased abundance of Superoxides]; Tacrolimus inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF protein]; Tacrolimus inhibits the reaction [enterotoxin A, Staphylococcal results in increased expression of TNF protein]; Tacrolimus inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Tacrolimus results in increased expression of TNF mRNA
Tacrolimus inhibits the reaction [Indomethacin results in increased expression of TNF mRNA]
[Tacrolimus co-treated with Thapsigargin] results in increased expression of TNF protein
Tacrolimus results in decreased expression of TNF mRNA; Tacrolimus results in decreased expression of TNF protein
Tacrolimus results in decreased secretion of TNF protein
CTD PMID:1371491, PMID:10339586, PMID:10385251, PMID:10685002, PMID:11121130, PMID:11169223, PMID:16181452, PMID:17202747, PMID:29362864 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip8l2 TNF alpha induced protein 8 like 2 increases expression ISO Tacrolimus results in increased expression of TNFAIP8L2 mRNA CTD PMID:29362864 NCBI chr 2:196,309,789...196,329,495
Ensembl chr 2:196,309,790...196,323,881
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B decreases expression EXP Tacrolimus results in decreased expression of TNFRSF11B mRNA CTD PMID:21865292 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Tacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 protein]; Tacrolimus inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:15207740, PMID:21869564 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression ISO Tacrolimus results in increased expression of TNNT2 protein CTD PMID:12975596 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP
ISO
Tacrolimus inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]
Tacrolimus inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TRP53 protein]
CTD PMID:10205001, PMID:12642403 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Tacrolimus results in increased expression of TRIB3 mRNA CTD PMID:23958496 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
JBrowse link
G Trim2 tripartite motif-containing 2 decreases expression ISO Tacrolimus results in decreased expression of TRIM2 mRNA CTD PMID:25270620 NCBI chr 2:183,145,096...183,223,819
Ensembl chr 2:183,145,089...183,213,228
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 increases expression ISO Tacrolimus results in increased expression of TRIP13 mRNA CTD PMID:29362864 NCBI chr 1:31,967,980...32,012,923
Ensembl chr 1:31,967,978...32,012,919
JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 decreases expression EXP Tacrolimus results in decreased expression of TRPM6 mRNA CTD PMID:14978156 NCBI chr 1:234,478,908...234,631,264
Ensembl chr 1:234,479,289...234,596,971
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO
EXP
Tacrolimus results in increased phosphorylation of and affects the activity of TRPV1 protein
Tacrolimus affects the reaction [resiniferatoxin affects the reaction [[Sodium Chloride co-treated with benzamil] results in increased activity of TRPV1 protein]]
CTD PMID:19553475 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Trpv5 transient receptor potential cation channel, subfamily V, member 5 decreases expression EXP Tacrolimus results in decreased expression of TRPV5 mRNA; Tacrolimus results in decreased expression of TRPV5 protein CTD PMID:14978156 NCBI chr 4:70,947,615...70,974,004
Ensembl chr 4:70,947,717...70,974,006
JBrowse link
G Txn1 thioredoxin 1 decreases expression EXP Tacrolimus results in decreased expression of TXN mRNA CTD PMID:17085464 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Ubd ubiquitin D increases expression ISO Tacrolimus results in increased expression of UBD mRNA CTD PMID:29362864 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
JBrowse link
G Utf1 undifferentiated embryonic cell transcription factor 1 decreases expression ISO Tacrolimus results in decreased expression of UTF1 mRNA CTD PMID:25270620 NCBI chr 1:212,281,237...212,282,363
Ensembl chr 1:212,281,237...212,282,363
JBrowse link
G Vasn vasorin decreases expression EXP Tacrolimus results in decreased expression of VASN mRNA CTD PMID:17028423 NCBI chr10:11,121,041...11,131,548
Ensembl chr10:11,121,041...11,131,548
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases expression ISO Tacrolimus results in decreased expression of VASP mRNA CTD PMID:29380240 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Tacrolimus results in increased expression of VCAM1 mRNA CTD PMID:23958496, PMID:29362864 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vcan versican increases expression EXP Tacrolimus results in increased expression of VCAN mRNA CTD PMID:21865292 NCBI chr 2:18,490,102...18,587,340
Ensembl chr 2:18,490,102...18,565,842
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression EXP Tacrolimus results in increased expression of VEGFA protein CTD PMID:17703430 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin increases expression ISO Tacrolimus results in increased expression of VIM protein CTD PMID:22416070, PMID:29362864 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wdfy4 WDFY family member 4 increases expression ISO Tacrolimus results in increased expression of WDFY4 mRNA CTD PMID:29362864 NCBI chr16:9,194,446...9,430,764
Ensembl chr16:9,194,424...9,430,743
JBrowse link
G Wdr31 WD repeat domain 31 decreases expression ISO Tacrolimus results in decreased expression of WDR31 mRNA CTD PMID:25270620 NCBI chr 5:78,305,526...78,324,318
Ensembl chr 5:78,305,526...78,324,278
JBrowse link
G Wdr73 WD repeat domain 73 decreases expression ISO Tacrolimus results in decreased expression of WDR73 mRNA CTD PMID:25270620 NCBI chr 1:142,711,955...142,720,292
Ensembl chr 1:142,711,789...142,720,257
JBrowse link
G Wfdc18 WAP four-disulfide core domain 18 increases expression ISO Tacrolimus results in increased expression of WFDC18 mRNA CTD PMID:29362864 NCBI chr10:71,008,709...71,010,863
Ensembl chr10:71,008,709...71,010,863
JBrowse link
G Wnk3 WNK lysine deficient protein kinase 3 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of WNK3 protein CTD PMID:21963515 NCBI chr  X:20,316,081...20,459,245
Ensembl chr  X:20,316,893...20,454,357
JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 increases phosphorylation ISO Tacrolimus results in increased phosphorylation of WNK4 protein CTD PMID:21963515 NCBI chr10:89,181,139...89,198,213
Ensembl chr10:89,181,165...89,198,213
JBrowse link
G Xbp1 X-box binding protein 1 multiple interactions
increases expression
ISO Tacrolimus results in increased expression of and affects the localization of XBP1 protein modified form
Tacrolimus results in increased expression of XBP1 mRNA
CTD PMID:23958496, PMID:25270620 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 increases expression ISO Tacrolimus results in increased expression of XCL1 mRNA CTD PMID:29362864 NCBI chr13:83,199,402...83,202,845
Ensembl chr13:83,199,264...83,202,864
JBrowse link
G Zfyve16 zinc finger FYVE-type containing 16 increases expression ISO Tacrolimus results in increased expression of ZFYVE16 mRNA CTD PMID:25270620 NCBI chr 2:22,060,879...22,105,822
Ensembl chr 2:22,062,050...22,105,710
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        immunomodulator 13691
          immunosuppressive agent 11937
            tacrolimus (anhydrous) 421
              tacrolimus hydrate 421
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                lactam 8027
                                                  macrolide lactam 769
                                                    tacrolimus (anhydrous) 421
                                                      tacrolimus hydrate 421
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.