CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: ganglioside GM1
Accession: CHEBI:61048
Definition: A sialotetraosylceramide consisting of a branched pentasaccharide made up from one sialyl residue, two galactose residues, one N-acetylgalactosamine residue and a glucose residue at the reducing end attached to N-stearoylsphingosine via a beta-linkage.
Synonyms: exact_synonym: (2S,3R,4E)-3-hydroxy-2-(octadecanoylamino)octadec-4-en-1-yl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranonosyl-(2->3)-[beta-D-galactopyranosyl-(1->3)-2-acetamido-2-deoxy-beta-D-galactopyranosyl-(1->4)]-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranoside related_synonym: (Neu5Ac)GM1; Formula=C73H131N3O31; G(M1) Ganglioside; GM1; Galbeta1->3GalNAcbeta1->4(Neu5Acalpha2->3)Galbeta1->4Glcbeta1->1-Cer; Galbeta1->3GalNAcbeta1->4(NeuAcalpha2->3)Galbeta1->4Glc-Cer; Ganglioside A2; Ganglioside G4; Ganglioside GGtet1; Ganglioside GI; Ganglioside GM1 (18:1/18:0); Ganglioside GM1a; Ganglioside M1; InChI=1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(87)76-44(45(84)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)41-98-69-61(94)59(92)63(50(39-80)101-69)103-71-62(95)67(107-73(72(96)97)35-46(85)53(74-42(3)82)66(106-73)55(88)47(86)36-77)64(51(40-81)102-71)104-68-54(75-43(4)83)65(57(90)49(38-79)99-68)105-70-60(93)58(91)56(89)48(37-78)100-70/h31,33,44-51,53-71,77-81,84-86,88-95H,5-30,32,34-41H2,1-4H3,(H,74,82)(H,75,83)(H,76,87)(H,96,97)/b33-31+/t44-,45+,46-,47+,48+,49+,50+,51+,53+,54+,55+,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66+,67+,68-,69+,70-,71-,73-/m0/s1; InChIKey=QPJBWNIQKHGLAU-IQZHVAEDSA-N; Monosialosyl tetraglycosyl ceramide; SMILES=CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO[C@@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O[C@@H]4O[C@H](CO)[C@H](O)[C@H](O)[C@H]4O)[C@H]3NC(C)=O)[C@H](O[C@@]3(C[C@H](O)[C@@H](NC(C)=O)[C@@H](O3)[C@H](O)[C@H](O)CO)C(O)=O)[C@H]2O)[C@H](O)[C@H]1O)[C@H](O)\\C=C\\CCCCCCCCCCCCC; Sialosylganglio-N-tetraosylceramide; alpha-Neu5Ac-(2->3)-[beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-N-octadecanoylsphingosine; alpha-Neu5Ac-(2->3)-[beta-D-Gal-(1->3)-beta-D-GalNAc-(1->4)]-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-N-stearoylsphingosine; alpha-Neup5Ac-(2->3)-[beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->4)]-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-N-stearoylsphingosine; monosialoganglioside GM1 xref: CAS:37758-47-7; HMDB:HMDB0004856 xref_mesh: MESH:D005677 xref: PMID:1567198; PMID:1724444; PMID:17855742; PMID:19221437; PMID:2448252; PMID:24841627; PMID:27242221; PMID:27485170; PMID:7691279; PMID:8120143; PMID:8410057; PMID:8448384; Reaxys:7196494; Wikipedia:GM1 cyclic_relationship: is_conjugate_acid_of CHEBI:73110
G
Cd14 CD14 antigen
multiple interactions
ISO CD14 protein affects the reaction [G(M1) Ganglioside results in increased secretion of Nitric Oxide]
CTD PMID:16651628
NCBI chr18:36,858,117...36,859,868
G
Cdkn1a cyclin dependent kinase inhibitor 1A
increases expression
ISO G(M1) Ganglioside results in increased expression of CDKN1A protein
CTD PMID:15654767
NCBI chr17:29,309,953...29,319,696
G
Cdkn1b cyclin dependent kinase inhibitor 1B
decreases expression
ISO G(M1) Ganglioside results in decreased expression of CDKN1B protein
CTD PMID:15654767
NCBI chr 6:134,897,364...134,902,488
G
Npc1 NPC intracellular cholesterol transporter 1
affects localization
EXP NPC1 affects the localization of G(M1) Ganglioside
CTD PMID:12183525
NCBI chr18:12,322,751...12,369,851
G
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1
multiple interactions
ISO G(M1) Ganglioside inhibits the reaction [Methylmercury Compounds results in decreased phosphorylation of NTRK1 protein]; G(M1) Ganglioside inhibits the reaction [staurosporine aglycone results in decreased phosphorylation of NTRK1 protein]
CTD PMID:25545984
NCBI chr 3:87,685,551...87,702,549
G
Pld1 phospholipase D1
multiple interactions
ISO PLD1 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside]
CTD PMID:19794068
NCBI chr 3:27,992,636...28,187,388
G
Pld2 phospholipase D2
multiple interactions
ISO PLD2 protein affects the reaction [dinitrophenyl-bovine serum albumin affects the localization of G(M1) Ganglioside]
CTD PMID:19794068
NCBI chr11:70,430,318...70,448,936
G
Slc18a2 solute carrier family 18 (vesicular monoamine), member 2
increases expression
ISO G(M1) Ganglioside results in increased expression of SLC18A2 mRNA
CTD PMID:14552908
NCBI chr19:59,249,310...59,284,444
G
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
increases expression
ISO G(M1) Ganglioside results in increased expression of SLC6A3 mRNA
CTD PMID:14552908
NCBI chr13:73,684,270...73,726,791
G
Th tyrosine hydroxylase
increases activity
ISO G(M1) Ganglioside results in increased activity of TH protein
CTD PMID:14552908
NCBI chr 7:142,446,516...142,453,732
G
Tlr4 toll-like receptor 4
decreases expression
ISO G(M1) Ganglioside results in decreased expression of TLR4 protein
CTD PMID:16651628
NCBI chr 4:66,745,788...66,765,338
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