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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:angiotensin receptor antagonist
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Accession:CHEBI:61016 term browser browse the term
Definition:A hormone antagonist that blocks angiotensin receptors.
Synonyms:related_synonym: angiotensin receptor antagonists


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azilsartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Zinc Sulfate binds to azilsartan] which results in increased expression of BAX protein CTD PMID:29408668 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Zinc Sulfate binds to azilsartan] which results in decreased expression of BCL2L1 protein CTD PMID:29408668 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Zinc Sulfate binds to azilsartan] which results in increased expression of CASP9 protein CTD PMID:29408668 NCBI chr 5:154,108,872...154,126,628 JBrowse link
candesartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme affects expression EXP candesartan affects the expression of ACE mRNA CTD PMID:18796534 NCBI chr10:90,910,316...90,930,437 JBrowse link
G Ace2 angiotensin I converting enzyme 2 decreases expression EXP candesartan results in decreased expression of ACE2 mRNA CTD PMID:18796534 NCBI chr  X:30,293,597...30,340,961 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
decreases expression
increases expression
ISO [candesartan co-treated with Fenofibrate] results in increased expression of ADIPOQ protein; candesartan promotes the reaction [Ramipril results in increased expression of ADIPOQ]; Ramipril promotes the reaction [candesartan results in increased expression of ADIPOQ]
candesartan results in decreased expression of ADIPOQ
candesartan results in increased expression of ADIPOQ; candesartan results in increased expression of ADIPOQ protein
CTD PMID:16443859 PMID:17483542 PMID:19059660 NCBI chr11:77,721,912...77,735,644 JBrowse link
G Agt angiotensinogen multiple interactions ISO
EXP
candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]; candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Nitric Oxide]; candesartan inhibits the reaction [AGT protein results in increased chemical synthesis of Reactive Oxygen Species]
candesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; candesartan inhibits the reaction [AGT protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; candesartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
candesartan inhibits the reaction [AGT protein modified form results in increased expression of COL1A2 protein]; candesartan inhibits the reaction [AGT results in increased expression of NOS3 protein]; candesartan inhibits the reaction [AGT results in increased expression of PTGS2 protein]; candesartan inhibits the reaction [AGT results in increased expression of VEGFA protein]
CTD PMID:10525314 PMID:11729239 PMID:12065685 PMID:15539634 PMID:15728788 PMID:18551021 PMID:18679781 PMID:23300732 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression
ISO
EXP
candesartan binds to and results in decreased activity of AGTR1 protein
candesartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
candesartan results in decreased expression of AGTR1A mRNA
CTD PMID:15728788 PMID:18796534 PMID:21474964 NCBI chr17:34,173,446...34,226,892 JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
decreases expression
ISO
EXP
[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]
candesartan results in decreased expression of AGTR2 mRNA
CTD PMID:18551021 PMID:18796534 NCBI chr  X:112,119,673...112,124,060 JBrowse link
G Akap11 A-kinase anchoring protein 11 increases expression EXP candesartan results in increased expression of AKAP11 mRNA CTD PMID:14871019 NCBI chr15:53,911,635...53,956,138 JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B decreases expression EXP candesartan results in decreased expression of AKR1B1 mRNA CTD PMID:14871019 NCBI chr 4:62,932,033...62,946,126 JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP candesartan results in decreased phosphorylation of AKT1 protein CTD PMID:17922026 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP candesartan inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 protein] CTD PMID:16723803 NCBI chr12:34,072,710...34,122,142 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP candesartan results in increased expression of BAX mRNA; candesartan results in increased expression of BAX protein CTD PMID:11409658 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bdkrb2 bradykinin receptor B2 decreases expression EXP candesartan results in decreased expression of BDKRB2 mRNA CTD PMID:18796534 NCBI chr 6:124,472,317...124,502,497 JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO candesartan results in decreased activity of CA1 protein CTD PMID:11196069 NCBI chr 2:86,829,436...86,872,209 JBrowse link
G Casp3 caspase 3 multiple interactions EXP [candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of CASP3 protein]; candesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; candesartan inhibits the reaction [Gentamicins results in increased expression of CASP3 protein] CTD PMID:23300732 PMID:30368989 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP candesartan results in decreased expression of CCN2 mRNA CTD PMID:16685210 NCBI chr 1:20,802,199...20,805,315 JBrowse link
G Cd36 CD36 molecule multiple interactions
decreases expression
increases expression
ISO
EXP
T 0070907 inhibits the reaction [candesartan results in increased expression of CD36 mRNA]
candesartan results in decreased expression of CD36 mRNA
CTD PMID:14871019 PMID:22124178 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases expression
ISO candesartan promotes the reaction [Fenofibrate results in decreased expression of CD40LG protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CD40LG protein] CTD PMID:16443859 NCBI chr  X:135,127,119...135,138,302 JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO candesartan inhibits the reaction [AGT protein modified form results in increased expression of COL1A2 protein] CTD PMID:11729239 NCBI chr 4:32,563,938...32,598,868 JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 decreases expression EXP candesartan results in decreased expression of CRISPLD2 mRNA CTD PMID:14871019 NCBI chr19:48,053,153...48,111,485 JBrowse link
G Crp C-reactive protein multiple interactions
decreases expression
ISO candesartan promotes the reaction [Fenofibrate results in decreased expression of CRP protein]; Fenofibrate promotes the reaction [candesartan results in decreased expression of CRP protein] CTD PMID:14620923 PMID:16443859 NCBI chr13:85,131,635...85,175,179 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP candesartan inhibits the reaction [Indomethacin results in increased expression of CXCL1 protein] CTD PMID:17763956 NCBI chr14:17,193,364...17,195,143 JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions
ISO
EXP
candesartan results in decreased expression of CYBA protein
candesartan results in decreased expression of CYBA; candesartan results in decreased expression of CYBA mRNA
Amlodipine promotes the reaction [candesartan results in decreased expression of CYBA]; candesartan inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBA]
CTD PMID:16139267 PMID:16685210 PMID:18551021 PMID:21107329 NCBI chr19:50,487,598...50,495,669 JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
EXP Amlodipine promotes the reaction [candesartan results in decreased expression of CYBB]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of CYBB]
candesartan results in decreased expression of CYBB; candesartan results in decreased expression of CYBB mRNA
CTD PMID:16685210 PMID:21107329 NCBI chr  X:13,360,583...13,392,517 JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 affects response to substance
decreases expression
ISO
EXP
CYP11B2 protein polymorphism affects the susceptibility to candesartan
candesartan results in decreased expression of CYP11B2 mRNA
CTD PMID:12065207 PMID:18796534 NCBI chr 7:106,808,559...106,814,048 JBrowse link
G Eng endoglin multiple interactions EXP candesartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 3:15,934,566...15,972,618 JBrowse link
G Faslg Fas ligand multiple interactions EXP candesartan inhibits the reaction [Daunorubicin results in increased expression of FASLG protein] CTD PMID:16324756 NCBI chr13:74,151,519...74,172,760 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP candesartan inhibits the reaction [[Acetaldehyde co-treated with Cyanamide] results in increased expression of FOS protein]; candesartan inhibits the reaction [Acetaldehyde promotes the reaction [Cyanamide results in increased expression of FOS protein]] CTD PMID:26298003 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein] CTD PMID:21255808 NCBI chr 2:136,312,168...136,390,603 JBrowse link
G Gcg glucagon multiple interactions ISO [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of FOXO1 protein]; [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein] CTD PMID:21255808 NCBI chr 3:47,113,914...47,122,929 JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 decreases expression EXP candesartan results in decreased expression of HSPE1 mRNA CTD PMID:14871019 NCBI chr 9:56,589,912...56,593,000 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP candesartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein] CTD PMID:16139267 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein decreases expression EXP candesartan results in decreased expression of ID1 mRNA CTD PMID:14871019 NCBI chr 3:141,210,666...141,212,420 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of IL1B protein]; candesartan inhibits the reaction [Gentamicins results in increased expression of IL1B protein] CTD PMID:30368989 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions EXP candesartan inhibits the reaction [AGT protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; candesartan inhibits the reaction [AGT protein results in increased expression of IL6 protein] CTD PMID:10525314 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions ISO [GCG protein co-treated with candesartan] inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein]; candesartan inhibits the reaction [Palmitic Acid results in decreased phosphorylation of IRS2 protein] CTD PMID:21255808 NCBI chr16:78,488,249...78,512,482 JBrowse link
G Klk1 kallikrein 1 decreases expression EXP candesartan results in decreased expression of KLK1 mRNA CTD PMID:18796534 NCBI chr 1:94,642,722...94,646,714 JBrowse link
G Lep leptin multiple interactions
increases response to substance
decreases expression
ISO
EXP
candesartan promotes the reaction [Ramipril results in increased expression of LEP]; Ramipril promotes the reaction [candesartan results in increased expression of LEP]
LEP protein results in increased susceptibility to candesartan
candesartan results in decreased expression of LEP
CTD PMID:17483542 PMID:19059660 PMID:21287150 NCBI chr 4:57,661,127...57,675,262 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:23300732 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP candesartan inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:23300732 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of MAPK8 protein] CTD PMID:20562518 NCBI chr16:8,638,897...8,721,960 JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression EXP candesartan results in increased expression of MMP13 protein CTD PMID:19047581 NCBI chr 8:4,497,960...4,508,239 JBrowse link
G Mmp15 matrix metallopeptidase 15 increases expression EXP candesartan results in increased expression of MMP15 mRNA CTD PMID:19047581 NCBI chr19:9,663,449...9,684,943 JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP candesartan results in decreased expression of MMP9 mRNA; candesartan results in decreased expression of MMP9 protein CTD PMID:19047581 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP candesartan inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:17763956 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP candesartan inhibits the reaction [Streptozocin results in increased expression of NOS2 protein] CTD PMID:16139267 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO
EXP
[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]
candesartan inhibits the reaction [Streptozocin results in increased expression of NOS3 mRNA]; candesartan inhibits the reaction [Streptozocin results in increased expression of NOS3 protein]
candesartan inhibits the reaction [AGT results in increased expression of NOS3 protein]
CTD PMID:12065685 PMID:16139267 PMID:18551021 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions
decreases expression
EXP Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX1] CTD PMID:21107329 NCBI chr  X:97,279,058...97,332,291 JBrowse link
G Nox4 NADPH oxidase 4 decreases expression
multiple interactions
ISO
EXP
candesartan results in decreased expression of NOX4 protein
Amlodipine promotes the reaction [candesartan results in decreased expression of NOX4]; Hydrochlorothiazide promotes the reaction [candesartan results in decreased expression of NOX4]
CTD PMID:18551021 PMID:21107329 NCBI chr 1:140,900,886...141,078,844 JBrowse link
G Nppa natriuretic peptide A increases expression
increases secretion
EXP candesartan results in increased expression of NPPA mRNA; candesartan results in increased expression of NPPA protein
candesartan results in increased secretion of NPPA protein
CTD PMID:14639023 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 affects expression EXP candesartan affects the expression of NR3C2 mRNA CTD PMID:18796534 NCBI chr19:30,715,648...31,059,885 JBrowse link
G Olr737 olfactory receptor 737 increases expression EXP candesartan results in increased expression of OLR737 mRNA CTD PMID:14871019 NCBI chr 3:76,207,843...76,208,769 JBrowse link
G Pln phospholamban multiple interactions EXP candesartan inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein] CTD PMID:16723803 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pmch pro-melanin-concentrating hormone decreases expression EXP candesartan results in decreased expression of PMCH mRNA CTD PMID:21287150 NCBI chr 7:22,511,934...22,513,250 JBrowse link
G Ptgis prostaglandin I2 synthase decreases expression EXP candesartan results in decreased expression of PTGIS mRNA CTD PMID:14871019 NCBI chr 3:155,928,564...155,964,228 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO candesartan inhibits the reaction [AGT results in increased expression of PTGS2 protein] CTD PMID:12065685 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; candesartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:180,188,792...180,199,847 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased phosphorylation of RELA protein]; candesartan inhibits the reaction [Gentamicins results in increased phosphorylation of RELA protein] CTD PMID:30368989 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Ren renin multiple interactions
increases expression
decreases activity
ISO
EXP
candesartan inhibits the reaction [[AGT co-treated with REN] results in increased abundance of Aldosterone]
candesartan results in increased expression of REN mRNA
candesartan results in decreased activity of REN protein
CTD PMID:18679781 PMID:18796534 PMID:19047581 NCBI chr13:44,796,260...44,807,491 JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions EXP candesartan inhibits the reaction [Isoproterenol results in increased phosphorylation of RYR2 protein] CTD PMID:16723803 NCBI chr17:58,389,925...58,975,641 JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO candesartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:205,338,698...205,498,486 JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP [benazepril co-treated with candesartan] results in decreased expression of SMAD3 protein CTD PMID:19487956 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [benazepril co-treated with candesartan] results in decreased expression of TGFB1 protein; candesartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of TGFB1 mRNA] CTD PMID:16778335 PMID:19487956 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Thbd thrombomodulin multiple interactions EXP candesartan inhibits the reaction [Nitric Oxide deficiency results in decreased expression of THBD protein] CTD PMID:16778335 NCBI chr 3:135,863,366...135,867,018 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression EXP candesartan results in decreased expression of TIMP2 mRNA CTD PMID:19047581 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression EXP candesartan results in decreased expression of TIMP3 mRNA CTD PMID:19047581 NCBI chr 7:17,520,827...17,571,871 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
candesartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; candesartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; T 0070907 inhibits the reaction [candesartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
[candesartan co-treated with epigallocatechin gallate] inhibits the reaction [Gentamicins results in increased expression of TNF protein]; candesartan inhibits the reaction [Gentamicins results in increased expression of TNF protein]
CTD PMID:22124178 PMID:30368989 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tp53 tumor protein p53 increases expression EXP candesartan results in increased expression of TP53 mRNA; candesartan results in increased expression of TP53 protein CTD PMID:11409658 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Ucp2 uncoupling protein 2 decreases expression
multiple interactions
EXP
ISO
candesartan results in decreased expression of UCP2 mRNA
candesartan inhibits the reaction [Palmitic Acid results in increased expression of UCP2 mRNA]
CTD PMID:16685210 PMID:20667613 NCBI chr 1:154,839,242...154,845,612 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP candesartan inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein] CTD PMID:16139267 NCBI chr 2:204,038,120...204,057,852 JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO candesartan results in decreased expression of VEGFA
candesartan inhibits the reaction [VEGFA protein results in increased expression of VEGFA mRNA]
candesartan inhibits the reaction [AGT results in increased expression of VEGFA protein]
CTD PMID:12065685 PMID:16202860 PMID:16675585 NCBI chr 9:14,955,300...14,970,641 JBrowse link
G Ybx3 Y box binding protein 3 decreases expression EXP candesartan results in decreased expression of YBX3 mRNA CTD PMID:14871019 NCBI chr 4:165,129,747...165,153,101 JBrowse link
eprosartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a1 collagen type I alpha 1 chain decreases expression EXP eprosartan decreases expression of collagen I-a1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr10:79,883,622...79,900,625 JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression EXP eprosartan decreases expression of collagen III mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr 9:47,374,611...47,410,547 JBrowse link
G Fn1 fibronectin 1 decreases expression EXP eprosartan decreases expression of fibronectin mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr 9:73,196,044...73,264,695 JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP eprosartan decreases expression of plasminogen activator inhibitor -1 mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr12:19,601,272...19,611,657 JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP eprosartan decreases expression of TGFbeta mRNA in high fat high sodium fed SHRSP/A3N rat kidney RGD PMID:11907153 RGD:28912746 NCBI chr 1:81,196,532...81,212,848 JBrowse link
irbesartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO irbesartan results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797 JBrowse link
G Ace2 angiotensin I converting enzyme 2 affects response to substance ISO ACE2 gene polymorphism affects the susceptibility to irbesartan CTD PMID:11593098 NCBI chr  X:30,293,597...30,340,961 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [irbesartan co-treated with benazepril] results in decreased expression of ACTA2 protein CTD PMID:15149348 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Agt angiotensinogen affects response to substance
multiple interactions
increases expression
ISO
EXP
AGT gene polymorphism affects the susceptibility to irbesartan; AGT gene SNP affects the susceptibility to irbesartan
irbesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]
irbesartan inhibits the reaction [AGT protein modified form results in increased susceptibility to Phenylephrine]
irbesartan results in increased expression of AGT protein
Cholesterol inhibits the reaction [irbesartan results in increased expression of AGT protein]
CTD PMID:10082498 PMID:11910301 PMID:14639093 PMID:15614026 PMID:16794485 PMID:19028402 PMID:23300732 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects response to substance
multiple interactions
ISO AGTR1 gene polymorphism affects the susceptibility to irbesartan
Cholesterol inhibits the reaction [irbesartan results in increased expression of AGTR1 mRNA]
irbesartan binds to and results in decreased activity of AGTR1 protein
CTD PMID:11910301 PMID:12022239 PMID:19028402 NCBI chr17:34,173,446...34,226,892 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of AKT1 protein] CTD PMID:19028402 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Alb albumin multiple interactions ISO Irbesartan inhibits the reaction [Acetaminophen results in increased expression of ALB protein] CTD PMID:31967706 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Apob apolipoprotein B affects response to substance ISO APOB gene SNP affects the susceptibility to irbesartan CTD PMID:15453913 PMID:15614026 NCBI chr 6:30,844,386...30,883,983 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
irbesartan inhibits the reaction [ioversol results in increased expression of BAX mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in increased expression of BAX protein]
CTD PMID:16828304 PMID:31967706 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO
irbesartan inhibits the reaction [ioversol results in decreased expression of BCL2 mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]
CTD PMID:16828304 PMID:31967706 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdkrb2 bradykinin receptor B2 affects response to substance ISO BDKRB2 exon polymorphism affects the susceptibility to irbesartan CTD PMID:12640257 NCBI chr 6:124,472,317...124,502,497 JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO irbesartan results in decreased activity of CA1 protein CTD PMID:11196069 NCBI chr 2:86,829,436...86,872,209 JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
Irbesartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Irbesartan inhibits the reaction [Indomethacin results in increased expression of CASP3 mRNA]
Irbesartan inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]
CTD PMID:23300732 PMID:29523851 PMID:31967706 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of CCL2 protein] CTD PMID:19028402 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein] CTD PMID:33380422 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 5:103,984,949...103,992,143 JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 increases response to substance ISO CYP11B2 gene SNP results in increased susceptibility to irbesartan CTD PMID:12022239 NCBI chr 7:106,808,559...106,814,048 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO irbesartan results in decreased activity of CYP2C8 protein CTD PMID:15601807
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Irbesartan inhibits the reaction [Acetaminophen results in increased expression of CYP2E1 protein] CTD PMID:31967706 NCBI chr 1:195,840,330...195,850,728 JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in decreased expression of DDAH1 mRNA] CTD PMID:29523851 NCBI chr 2:234,667,499...234,800,322 JBrowse link
G Edn1 endothelin 1 affects response to substance ISO EDN1 gene polymorphism affects the susceptibility to irbesartan CTD PMID:15188945 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in increased expression of EGFR mRNA] CTD PMID:29523851 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Erap1 endoplasmic reticulum aminopeptidase 1 affects response to substance ISO ERAP1 gene polymorphism affects the susceptibility to irbesartan CTD PMID:13678427 NCBI chr 2:3,931,817...3,970,735 JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of F3 mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of F3 protein CTD PMID:21229253 NCBI chr 2:209,827,061...209,838,666 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Irbesartan inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:31967706 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Ifng interferon gamma decreases expression ISO irbesartan results in decreased expression of IFNG protein CTD PMID:15210574 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Il6 interleukin 6 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of IL6 protein] CTD PMID:19028402 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein]
Irbesartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]
CTD PMID:33380422 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in increased expression of MMP9 protein] CTD PMID:29523851 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of NCF1 protein] CTD PMID:19028402 NCBI chr12:22,485,382...22,494,647 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of NFKB1 protein] CTD PMID:19028402 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased phosphorylation of NFKBIB protein] CTD PMID:19028402 NCBI chr 1:84,046,292...84,053,862 JBrowse link
G Nppa natriuretic peptide A increases expression ISO irbesartan results in increased expression of NPPA protein CTD PMID:12035877 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Irbesartan inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA] CTD PMID:29523851 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of RAC1 mRNA] CTD PMID:19028402 NCBI chr12:11,037,028...11,057,251 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of RELA protein] CTD PMID:19028402 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Ren renin increases expression ISO irbesartan results in increased expression of REN protein CTD PMID:14639093 NCBI chr13:44,796,260...44,807,491 JBrowse link
G Ret ret proto-oncogene increases expression ISO irbesartan results in increased expression of RET protein CTD PMID:16164579 NCBI chr 4:151,325,969...151,368,176 JBrowse link
G Smad2 SMAD family member 2 multiple interactions
affects expression
EXP [benazepril co-treated with irbesartan] affects the expression of SMAD2 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD2 protein
irbesartan affects the expression of SMAD2 mRNA; irbesartan affects the expression of SMAD2 protein
CTD PMID:16635409 NCBI chr18:69,849,884...69,918,926 JBrowse link
G Smad3 SMAD family member 3 multiple interactions
affects expression
EXP [benazepril co-treated with irbesartan] affects the expression of SMAD3 mRNA; [benazepril co-treated with irbesartan] affects the expression of SMAD3 protein
irbesartan affects the expression of SMAD3 mRNA; irbesartan affects the expression of SMAD3 protein
CTD PMID:16635409 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Tfpi tissue factor pathway inhibitor multiple interactions EXP [irbesartan co-treated with carvedilol] results in decreased expression of TFPI mRNA; [irbesartan co-treated with carvedilol] results in decreased expression of TFPI protein CTD PMID:21229253 NCBI chr 3:69,533,156...69,582,547 JBrowse link
G Tgfb1 transforming growth factor, beta 1 affects response to substance
multiple interactions
affects expression
decreases expression
ISO
EXP
TGFB1 gene SNP affects the susceptibility to irbesartan
[benazepril co-treated with irbesartan] affects the expression of TGFB1 mRNA
irbesartan affects the expression of TGFB1 mRNA
irbesartan results in decreased expression of TGFB1 mRNA
CTD PMID:11352773 PMID:15049387 PMID:16635409 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO
EXP
irbesartan results in decreased expression of TNF protein
Irbesartan inhibits the reaction [Indomethacin results in increased expression of TNF protein]
Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF mRNA]; Cholesterol inhibits the reaction [Irbesartan results in increased expression of TNF protein]; Irbesartan inhibits the reaction [Acetaminophen results in increased expression of TNF protein]
CTD PMID:15210574 PMID:19028402 PMID:29523851 PMID:31967706 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 mRNA]; Cholesterol inhibits the reaction [irbesartan results in increased expression of VCAM1 protein] CTD PMID:19028402 NCBI chr 2:204,038,120...204,057,852 JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Losartan results in decreased activity of ABCB11 protein
Losartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797 JBrowse link
G Ace angiotensin I converting enzyme multiple interactions
decreases expression
ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of ACE protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]
Losartan results in decreased expression of ACE protein
CTD PMID:25511041 PMID:25655897 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr10:90,910,316...90,930,437 JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions
increases activity
increases expression
EXP
ISO
Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of ACE2 protein]
Losartan results in increased activity of ACE2 protein
Losartan results in increased expression of ACE2 protein
Losartan results in increased expression of ACE2 mRNA; Losartan results in increased expression of ACE2 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]
CTD PMID:15897343 PMID:16176966 PMID:16221218 PMID:20178811 PMID:22009550 PMID:25511041 PMID:25655897 PMID:28091615 PMID:33007385 NCBI chr  X:30,293,597...30,340,961 JBrowse link
G Acta2 actin alpha 2, smooth muscle decreases expression
multiple interactions
EXP
ISO
Losartan results in decreased expression of ACTA2 mRNA; Losartan results in decreased expression of ACTA2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
CTD PMID:15100363 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Actg2 actin gamma 2, smooth muscle decreases expression EXP Losartan results in decreased expression of ACTG2 mRNA CTD PMID:15100363 NCBI chr 4:116,021,832...116,046,475 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO Losartan results in increased expression of ADIPOQ mRNA CTD PMID:19730415 NCBI chr11:77,721,912...77,735,644 JBrowse link
G Adrb2 adrenoceptor beta 2 affects expression EXP Losartan affects the expression of ADRB2 protein CTD PMID:9260993 NCBI chr18:55,642,459...55,644,501 JBrowse link
G Afp alpha-fetoprotein multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein] CTD PMID:29859236 NCBI chr14:17,573,412...17,591,476 JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Losartan inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Losartan inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr20:4,148,150...4,151,361 JBrowse link
G Agt angiotensinogen multiple interactions
increases secretion
decreases activity
decreases response to substance
increases expression
decreases expression
ISO
EXP
[Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein]; [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [4-hydroxy-2-nonenal binds to AGT protein modified form]]; Losartan inhibits the reaction [[AGT protein modified form co-treated with Ascorbic Acid co-treated with Copper Sulfate] results in increased chemical synthesis of [pyruvamide binds to AGT protein modified form]]; Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in decreased secretion of Nitric Oxide]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]
Losartan results in increased secretion of AGT protein; Losartan results in increased secretion of AGT protein alternative form
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein; Losartan results in decreased activity of AGT protein
Losartan results in decreased susceptibility to AGT protein modified form
Losartan results in increased expression of AGT protein
Losartan results in decreased activity of AGT protein; Losartan results in decreased activity of AGT protein modified form
Losartan results in decreased expression of AGT protein; Losartan results in decreased expression of AGT protein alternative form; Losartan results in decreased expression of AGT protein modified form
[Lisinopril co-treated with Losartan] results in increased expression of AGT mRNA; [Losartan co-treated with Carvedilol] results in decreased susceptibility to AGT protein modified form; Carvedilol inhibits the reaction [Losartan results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [AGT protein affects the abundance of Cholesterol]; Losartan inhibits the reaction [AGT protein affects the localization of Calcium]; Losartan inhibits the reaction [AGT protein affects the localization of Lipids]; Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form]; Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein]; Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased abundance of Fatty Acids, Nonesterified]; Losartan inhibits the reaction [AGT protein results in increased abundance of Glycerol]; Losartan inhibits the reaction [AGT protein results in increased abundance of Norepinephrine]; Losartan inhibits the reaction [AGT protein results in increased abundance of Triglycerides]; Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein]; Losartan inhibits the reaction [Carvedilol results in decreased susceptibility to AGT protein modified form]; Losartan inhibits the reaction [Ethanol results in increased secretion of AGT protein alternative form]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]; Losartan inhibits the reaction [Folic Acid results in increased localization of AGT protein]; Losartan inhibits the reaction [Isoproterenol results in increased expression of AGT protein]; Losartan inhibits the reaction [Sodium Chloride results in increased expression of AGT protein]; Losartan inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AGT protein]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of AGT protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Losartan inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of NPHS1 protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein]; Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein]; Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ACE protein]; Losartan inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGT protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of DES protein]; Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]
CTD PMID:1387008 PMID:7965263 PMID:8403307 PMID:8952583 PMID:9124547 PMID:9176287 PMID:9519251 PMID:9533614 PMID:10082498 PMID:10400907 PMID:10517737 PMID:11463773 PMID:11709406 PMID:11967826 PMID:12084390 PMID:12411096 PMID:12431451 PMID:12692751 PMID:14630723 PMID:14722030 PMID:15121739 PMID:15213268 PMID:15361886 PMID:15502880 PMID:15528393 PMID:15539634 PMID:15728788 PMID:15741261 PMID:15897343 PMID:16176966 PMID:16221218 PMID:16251426 PMID:16539842 PMID:17043664 PMID:17224469 PMID:17481528 PMID:17666345 PMID:18060435 PMID:18267125 PMID:18511912 PMID:19109942 PMID:19183357 PMID:19298698 PMID:20178811 PMID:20232302 PMID:21047287 PMID:21152098 PMID:21166975 PMID:21613610 PMID:21613793 PMID:22982071 PMID:22982863 PMID:23300732 PMID:23875703 PMID:25398788 PMID:26464165 PMID:27798352 PMID:28578904 PMID:29609002 PMID:31144504 PMID:33007385 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
decreases expression
increases expression
decreases activity
ISO
EXP
[Losartan results in decreased activity of AGTR1 protein] which results in decreased abundance of Aldosterone; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of AGT protein alternative form; [Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]
Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]
Losartan results in decreased expression of AGTR1 protein; Losartan results in decreased expression of AGTR1A mRNA; Losartan results in decreased expression of AGTR1A protein
Losartan results in increased expression of AGTR1 mRNA; Losartan results in increased expression of AGTR1A mRNA
[Cilazapril co-treated with Losartan] promotes the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan binds to and results in decreased activity of AGTR1 protein; Losartan binds to and results in decreased activity of AGTR1A protein; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of AGTR1A protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 mRNA]; Losartan inhibits the reaction [Doxorubicin results in increased expression of AGTR1 protein]; Losartan inhibits the reaction [Folic Acid results in increased localization of [AGT protein binds to AGTR1A protein]]
CTD PMID:9124547 PMID:9533614 PMID:10821809 PMID:11893553 PMID:12930639 PMID:15157388 PMID:15331931 PMID:15528393 PMID:15728788 PMID:15807884 PMID:15809360 PMID:18267125 PMID:18300857 PMID:18765277 PMID:22306536 PMID:25511041 PMID:28091615 PMID:28578904 PMID:33007385 NCBI chr17:34,173,446...34,226,892 JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
increases expression
decreases expression
EXP
ISO
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan inhibits the reaction [Doxorubicin results in decreased expression of AGTR2 mRNA]; Losartan promotes the reaction [AGTR2 protein binds to AGT protein]
Losartan inhibits the reaction [Oxygen deficiency results in decreased expression of AGTR2 protein]
Losartan results in increased expression of AGTR2 protein
Losartan results in decreased expression of AGTR2 mRNA
CTD PMID:9336375 PMID:11967826 PMID:15331931 PMID:18300857 PMID:25511041 NCBI chr  X:112,119,673...112,124,060 JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of AKT2 protein] CTD PMID:28578904 NCBI chr 1:82,877,228...82,933,828 JBrowse link
G Alb albumin affects binding ISO Losartan binds to ALB protein; Losartan binds to ALB protein modified form CTD PMID:27470663 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression EXP Losartan results in decreased expression of ALOX15 mRNA; Losartan results in decreased expression of ALOX15 protein CTD PMID:15100363 NCBI chr10:55,060,169...55,068,885 JBrowse link
G Alox5 arachidonate 5-lipoxygenase decreases expression EXP Losartan results in decreased expression of ALOX5 protein CTD PMID:21377515 NCBI chr 4:149,531,329...149,578,696 JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression
multiple interactions
ISO Losartan results in decreased expression of AMBP protein
benazepril promotes the reaction [Losartan results in decreased expression of AMBP protein]; Losartan promotes the reaction [benazepril results in decreased expression of AMBP protein]
CTD PMID:16303729 NCBI chr 5:76,568,094...76,578,416 JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of ATP1A1 mRNA] CTD PMID:14630723 NCBI chr 2:189,020,722...189,048,826 JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 increases expression EXP Losartan results in increased expression of ATP1A2 mRNA; Losartan results in increased expression of ATP1A2 protein CTD PMID:18418421 NCBI chr13:84,729,597...84,754,544 JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression EXP Losartan results in decreased expression of ATP1A3 mRNA; Losartan results in decreased expression of ATP1A3 protein CTD PMID:18418421 NCBI chr 1:80,572,790...80,601,936 JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions EXP Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAK1 mRNA] CTD PMID:15502641 NCBI chr20:5,100,480...5,109,669 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
EXP Losartan inhibits the reaction [AGT protein modified form results in increased expression of BAX protein]; Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]
Losartan results in increased expression of BAX protein
Losartan results in decreased expression of BAX mRNA
CTD PMID:12623880 PMID:12845756 PMID:15502641 PMID:17784886 PMID:19298698 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
affects expression
increases expression
decreases expression
EXP Losartan promotes the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA]
Losartan affects the expression of BCL2 protein
Losartan results in increased expression of BCL2 protein
Losartan results in decreased expression of BCL2 protein
CTD PMID:12623880 PMID:15502641 PMID:19298698 PMID:21153712 PMID:22000973 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of BMP2 protein] CTD PMID:27412937 NCBI chr 3:120,812,660...120,822,579 JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions ISO [KN 93 co-treated with Losartan] inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein]; Losartan inhibits the reaction [bisphenol A results in increased phosphorylation of CAMK2A protein] CTD PMID:25103225 NCBI chr18:54,378,642...54,441,120 JBrowse link
G Casp3 caspase 3 increases cleavage
decreases activity
multiple interactions
EXP Losartan results in increased cleavage of CASP3 protein
Losartan results in decreased activity of CASP3 protein
Losartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]
CTD PMID:12623880 PMID:23300732 PMID:23875703 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp8 caspase 8 decreases activity EXP Losartan results in decreased activity of CASP8 protein CTD PMID:23875703 NCBI chr 9:60,263,863...60,312,542 JBrowse link
G Casp9 caspase 9 increases cleavage EXP Losartan results in increased cleavage of CASP9 protein CTD PMID:12623880 NCBI chr 5:154,108,872...154,126,628 JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP Losartan results in decreased expression of CAT protein
Losartan inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
CTD PMID:23875703 PMID:30958922 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
EXP
ISO
Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL2 protein]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]
Losartan results in decreased expression of CCL2 mRNA; Losartan results in decreased expression of CCL2 protein
CTD PMID:10925121 PMID:16284884 PMID:17922026 PMID:19553526 PMID:28578904 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CCL3 protein] CTD PMID:19553526 NCBI chr10:68,451,388...68,452,938 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP Losartan inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:68,322,826...68,327,365 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA] CTD PMID:29859236 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression EXP Losartan results in decreased expression of CCR2 mRNA CTD PMID:17922026 NCBI chr 8:123,734,465...123,742,483 JBrowse link
G Cd36 CD36 molecule increases expression
decreases expression
multiple interactions
ISO Losartan results in increased expression of CD36 mRNA
Losartan results in decreased expression of CD36 mRNA
Losartan promotes the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of CD36 mRNA]
T 0070907 inhibits the reaction [Losartan results in increased expression of CD36 mRNA]
CTD PMID:18302760 PMID:22124178 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cd74 CD74 molecule decreases expression EXP Losartan results in decreased expression of CD74 mRNA CTD PMID:15100363 NCBI chr18:54,256,757...54,266,003 JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]
Losartan inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein]
CTD PMID:28578904 PMID:33007385 NCBI chr19:34,492,371...34,561,775 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein] CTD PMID:33380422 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 5:103,984,949...103,992,143 JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression
multiple interactions
EXP
ISO
Losartan results in decreased expression of COL1A1 mRNA
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL1A1 mRNA]
CTD PMID:15100363 PMID:18300870 PMID:23585870 NCBI chr10:79,883,622...79,900,625 JBrowse link
G Col3a1 collagen type III alpha 1 chain decreases expression
multiple interactions
EXP
ISO
Losartan results in decreased expression of COL3A1 mRNA
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]]
Losartan inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of COL3A1 mRNA]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein]
Losartan inhibits the reaction [AGT protein results in increased secretion of COL3A1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of COL3A1 protein]
CTD PMID:15100363 PMID:16539842 PMID:23585870 PMID:25233898 PMID:28578904 PMID:33007385 NCBI chr 9:47,374,611...47,410,547 JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression EXP Losartan results in decreased expression of COL4A1 mRNA CTD PMID:16191423 NCBI chr16:78,183,533...78,294,412 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP Losartan inhibits the reaction [AGT protein results in decreased expression of CPT1A mRNA] CTD PMID:19109942 NCBI chr 1:200,564,634...200,627,059 JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased activity of CREB1 protein]; Losartan inhibits the reaction [Folic Acid results in increased activity of CREB1 protein] CTD PMID:15728788 NCBI chr 9:65,903,511...65,972,562 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 protein]
Losartan inhibits the reaction [AGT protein affects the localization of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of and results in increased activity of CTNNB1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of CTNNB1 mRNA]
CTD PMID:28578904 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Cubn cubilin multiple interactions EXP Losartan inhibits the reaction [Cadmium results in decreased expression of CUBN protein] CTD PMID:24093454 NCBI chr17:76,385,046...76,593,133 JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of CXCL1 protein] CTD PMID:19553526 NCBI chr14:17,193,364...17,195,143 JBrowse link
G Cycs cytochrome c, somatic increases expression EXP Losartan results in increased expression of CYCS protein CTD PMID:18971572 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Losartan results in increased expression of CYP1A1 mRNA CTD PMID:9860486 NCBI chr 8:58,096,021...58,102,130 JBrowse link
G Dcn decorin decreases expression EXP Losartan results in decreased expression of DCN mRNA CTD PMID:15100363 NCBI chr 7:32,281,252...32,321,291 JBrowse link
G Des desmin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of DES protein] CTD PMID:28578904 NCBI chr 9:76,850,979...76,858,695 JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of EDN1 protein
Losartan results in decreased expression of EDN1 mRNA; Losartan results in decreased expression of EDN1 protein
Losartan inhibits the reaction [Nitroglycerin results in increased expression of EDN1 protein]
Losartan inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]
CTD PMID:11369837 PMID:12901495 PMID:16191423 PMID:17666345 PMID:18971572 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Ednra endothelin receptor type A multiple interactions
decreases expression
EXP Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA]; Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA] CTD PMID:23091284 NCBI chr19:30,233,540...30,303,727 JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased phosphorylation of EIF2S1 protein] CTD PMID:25398788 NCBI chr 6:97,672,829...97,697,499 JBrowse link
G Eln elastin decreases expression EXP Losartan results in decreased expression of ELN mRNA CTD PMID:15100363 NCBI chr12:21,968,544...22,011,929 JBrowse link
G Eng endoglin multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 3:15,934,566...15,972,618 JBrowse link
G F3 coagulation factor III, tissue factor decreases expression
multiple interactions
ISO Losartan results in decreased expression of F3 mRNA; Losartan results in decreased expression of F3 protein
Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]
CTD PMID:18060435 PMID:22188725 NCBI chr 2:209,827,061...209,838,666 JBrowse link
G Faslg Fas ligand decreases expression EXP Losartan results in decreased expression of FASLG mRNA CTD PMID:10925121 NCBI chr13:74,151,519...74,172,760 JBrowse link
G Fasn fatty acid synthase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of FASN mRNA] CTD PMID:19109942 NCBI chr10:106,072,093...106,090,259 JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 decreases expression ISO Losartan results in decreased expression of FLT1 mRNA; Losartan results in decreased expression of FLT1 protein CTD PMID:19771429 NCBI chr12:7,296,899...7,468,626 JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 decreases expression ISO Losartan results in decreased expression of FLT4 mRNA CTD PMID:19771429 NCBI chr10:33,913,725...33,954,770 JBrowse link
G Fn1 fibronectin 1 decreases expression EXP Losartan results in decreased expression of FN1 mRNA; Losartan results in decreased expression of FN1 protein CTD PMID:16191423 NCBI chr 9:73,196,044...73,264,695 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
Losartan inhibits the reaction [AGT protein results in increased expression of FOS protein]; Losartan inhibits the reaction [Furosemide results in increased expression of FOS protein]; Losartan inhibits the reaction [Polyethylene Glycols results in increased expression of FOS protein] CTD PMID:11463773 PMID:15528393 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP Losartan results in increased expression of GJA1 protein CTD PMID:18971572 NCBI chr20:35,756,007...35,768,481 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP
ISO
Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]
CTD PMID:15573910 PMID:29859236 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of GSK3B protein] CTD PMID:22982863 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP Losartan inhibits the reaction [Cadmium results in increased expression of HAVCR1] CTD PMID:24093454 NCBI chr10:31,118,667...31,151,730 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of HMGCR mRNA] CTD PMID:19109942 NCBI chr 2:27,997,523...28,018,983 JBrowse link
G Hmox1 heme oxygenase 1 increases activity
multiple interactions
increases expression
EXP
ISO
Losartan results in increased activity of HMOX1 protein
Losartan inhibits the reaction [AGT protein results in decreased expression of HMOX1 protein]
Losartan results in increased expression of HMOX1 mRNA
cobaltiprotoporphyrin promotes the reaction [Losartan results in increased activity of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Losartan results in increased expression of HMOX1 mRNA]
CTD PMID:19804535 PMID:28578904 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of HSPA5 protein] CTD PMID:25398788 NCBI chr 3:18,055,507...18,059,969 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
decreases secretion
ISO Losartan inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]
Losartan results in decreased secretion of ICAM1 protein
CTD PMID:10517737 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Ifng interferon gamma increases expression EXP Losartan results in increased expression of IFNG protein CTD PMID:23875703 NCBI chr 7:53,903,339...53,907,375 JBrowse link
G Il10 interleukin 10 increases expression EXP Losartan results in increased expression of IL10 mRNA CTD PMID:18971572 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression
ISO
EXP
Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]
Losartan results in decreased expression of IL1A protein
CTD PMID:17299153 PMID:23875703 NCBI chr 3:116,526,601...116,537,055 JBrowse link
G Il6 interleukin 6 decreases expression
increases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of IL6 mRNA
Losartan results in increased expression of IL6 protein
Losartan inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Losartan inhibits the reaction [Ethylene Glycol results in increased expression of IL6 protein]
CTD PMID:16284884 PMID:21479465 PMID:23875703 PMID:30677511 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Itga3 integrin subunit alpha 3 decreases expression EXP Losartan results in decreased expression of ITGA3 protein CTD PMID:15100363 NCBI chr10:79,990,160...80,022,206 JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression EXP Losartan results in decreased expression of ITGA6 protein CTD PMID:15100363 NCBI chr 3:56,604,512...56,689,428 JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver] RGD PMID:22613986 RGD:127285667 NCBI chr 1:226,995,334...227,054,381 JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Losartan inhibits the reaction [Cyclosporine results in increased expression of KDR mRNA] CTD PMID:12110003 NCBI chr14:32,217,871...32,261,018 JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN1A protein]; Losartan inhibits the reaction [KRAS protein mutant form results in increased expression of CDKN2A protein] CTD PMID:33380422 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lox lysyl oxidase decreases expression EXP Losartan results in decreased expression of LOX mRNA CTD PMID:15100363 NCBI chr18:45,964,311...46,041,477 JBrowse link
G Lum lumican decreases expression EXP Losartan results in decreased expression of LUM mRNA CTD PMID:15100363 NCBI chr 7:32,358,990...32,365,794 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
increases activity
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK1 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]
Losartan results in increased activity of MAPK1 protein
Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK1 protein]
CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression EXP Losartan results in decreased expression of MAPK14 protein CTD PMID:28091615 NCBI chr20:6,749,646...6,810,590 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
increases activity
ISO
EXP
Losartan inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK3 protein]
Losartan results in increased phosphorylation of MAPK3 protein
Losartan results in increased activity of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of MAPK3 protein]; Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:11711055 PMID:16079071 PMID:18267125 PMID:18511912 PMID:20056918 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased phosphorylation of MAPT protein] CTD PMID:22982863 NCBI chr10:89,138,644...89,236,137 JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Losartan inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein] CTD PMID:33007385 NCBI chr 1:47,879,956...47,911,500 JBrowse link
G Mgp matrix Gla protein decreases expression EXP Losartan results in decreased expression of MGP mRNA CTD PMID:15100363 NCBI chr 4:169,766,290...169,769,612 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP
ISO
Losartan inhibits the reaction [[Phenylephrine results in increased expression of AGT protein] which results in increased activity of MMP2 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MMP2 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of MMP2 protein]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]
CTD PMID:12930639 PMID:16251426 PMID:23585870 PMID:29859236 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mmp23 matrix metallopeptidase 23 decreases expression EXP Losartan results in decreased expression of MMP23 mRNA CTD PMID:15100363 NCBI chr 5:166,239,643...166,242,734 JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of MMP7 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of MMP7 protein]] CTD PMID:28578904 NCBI chr 8:4,848,186...4,855,908 JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
EXP
ISO
Losartan results in decreased expression of MMP9 mRNA
Losartan inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]
Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]
CTD PMID:18971572 PMID:23585870 PMID:25233898 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor affects expression EXP Losartan affects the expression of MYC protein CTD PMID:22000973 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Myh11 myosin heavy chain 11 decreases expression EXP Losartan results in decreased expression of MYH11 mRNA CTD PMID:15100363 NCBI chr10:743,364...838,459 JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 mRNA]; Losartan inhibits the reaction [Streptozocin results in decreased expression of MYH6 protein] CTD PMID:15362513 NCBI chr15:28,418,120...28,442,316 JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 mRNA]; Losartan inhibits the reaction [Streptozocin results in increased expression of MYH7 protein] CTD PMID:15362513 NCBI chr15:28,446,550...28,469,888 JBrowse link
G Mylk myosin light chain kinase multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of MYLK protein] CTD PMID:18511912 NCBI chr11:65,783,008...66,030,239 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions ISO
EXP
Losartan inhibits the reaction [Hydrogen Peroxide results in increased expression of NCF1 mRNA]
Losartan inhibits the reaction [Ethanol affects the localization of NCF1 protein]
CTD PMID:22306536 PMID:22497828 PMID:22982071 NCBI chr12:22,485,382...22,494,647 JBrowse link
G Ndst1 N-deacetylase and N-sulfotransferase 1 multiple interactions EXP Losartan inhibits the reaction [Streptozocin results in decreased expression of NDST1 protein] CTD PMID:15793251 NCBI chr18:54,136,887...54,199,545 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
multiple interactions
EXP
ISO
Losartan results in decreased expression of NFE2L2 mRNA
Losartan inhibits the reaction [AGT protein results in decreased expression of NFE2L2 protein]
CTD PMID:18765277 PMID:28578904 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP
ISO
Losartan inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein]
Losartan inhibits the reaction [Diethylnitrosamine results in decreased expression of NFKB1 protein]
CTD PMID:16284884 PMID:29859236 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nos1 nitric oxide synthase 1 increases phosphorylation
multiple interactions
EXP Losartan results in increased phosphorylation of NOS1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Losartan results in increased phosphorylation of NOS1 protein]
CTD PMID:20056918 NCBI chr12:38,615,111...38,795,492 JBrowse link
G Nos2 nitric oxide synthase 2 affects expression
decreases expression
increases expression
EXP Losartan affects the expression of NOS2 mRNA
Losartan results in decreased expression of NOS2 mRNA; Losartan results in decreased expression of NOS2 protein
Losartan results in increased expression of NOS2 protein
CTD PMID:12198324 PMID:16191423 PMID:18390819 PMID:21377515 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nos3 nitric oxide synthase 3 affects expression
increases expression
multiple interactions
increases phosphorylation
EXP Losartan affects the expression of NOS3 mRNA
Losartan results in increased expression of NOS3 mRNA
[Losartan co-treated with Atorvastatin] results in increased expression of NOS3 mRNA; Losartan inhibits the reaction [Sodium Chloride results in decreased expression of NOS3 protein]
Losartan results in increased phosphorylation of NOS3 protein
CTD PMID:12198324 PMID:18390819 PMID:18971572 PMID:20232302 PMID:23091284 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in decreased expression of NPHS2 protein] CTD PMID:28578904 NCBI chr13:68,448,720...68,461,312 JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression
EXP Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPA mRNA]
Losartan results in decreased expression of NPPA protein
CTD PMID:12198334 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
EXP [Atenolol co-treated with Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Doxazosin] results in decreased expression of NPPB mRNA; [Losartan co-treated with Nifedipine] results in decreased expression of NPPB mRNA; Losartan inhibits the reaction [Nitric Oxide deficiency results in increased expression of NPPB mRNA]
Losartan results in decreased expression of NPPB mRNA; Losartan results in decreased expression of NPPB protein
CTD PMID:12198334 PMID:15969258 PMID:17666919 NCBI chr 5:158,416,813...158,418,175 JBrowse link
G Npr1 natriuretic peptide receptor 1 affects response to substance ISO NPR1 protein mutant form affects the susceptibility to Losartan CTD PMID:20881240 NCBI chr 2:175,934,181...175,950,118 JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression EXP Losartan results in increased expression of NR1H3 protein CTD PMID:28091615 NCBI chr 3:77,158,808...77,168,907 JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression EXP Losartan results in increased expression of NRF1 mRNA CTD PMID:18765277 NCBI chr 4:58,664,932...58,772,328 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
Losartan inhibits the reaction [AGT protein results in increased expression of PARP1 protein]
Losartan inhibits the reaction [AGT protein results in increased activity of PARP1 protein]
CTD PMID:15502880 PMID:21613793 NCBI chr13:92,307,593...92,339,406 JBrowse link
G Pdgfa platelet derived growth factor subunit A multiple interactions EXP Losartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form] CTD PMID:12431451 NCBI chr12:15,645,549...15,667,056 JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein] CTD PMID:12930639 PMID:17043664 NCBI chr 7:111,539,444...111,557,984 JBrowse link
G Pdgfd platelet derived growth factor D multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFD mRNA] CTD PMID:17043664 NCBI chr 8:3,488,448...3,722,395 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA] CTD PMID:17043664 NCBI chr18:54,500,002...54,538,843 JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression EXP Losartan results in decreased expression of PDLIM3 mRNA CTD PMID:15100363 NCBI chr16:46,352,460...46,383,680 JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Losartan results in decreased expression of PECAM1 mRNA CTD PMID:19771429 NCBI chr10:91,590,521...91,652,279 JBrowse link
G Plat plasminogen activator, tissue type decreases expression EXP Losartan results in decreased expression of PLAT mRNA CTD PMID:15100363 NCBI chr16:69,240,582...69,265,177 JBrowse link
G Podxl podocalyxin-like multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of PODXL protein] CTD PMID:28578904 NCBI chr 4:60,135,124...60,181,829 JBrowse link
G Postn periostin multiple interactions
decreases expression
EXP
ISO
Losartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]
Losartan results in decreased expression of POSTN mRNA
CTD PMID:15121739 PMID:21641384 NCBI chr 2:138,527,714...138,559,098 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PPARA mRNA] CTD PMID:19109942 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP
ISO
Losartan inhibits the reaction [AGT protein results in increased expression of PPARG mRNA]
Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in increased expression of PPARG mRNA]
CTD PMID:18302760 PMID:19109942 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
EXP Losartan inhibits the reaction [AGT protein results in increased expression of PPARGC1A mRNA]
Losartan results in increased expression of PPARGC1A mRNA
CTD PMID:18765277 PMID:18971572 PMID:19109942 NCBI chr14:58,860,752...59,516,525 JBrowse link
G Prkcb protein kinase C, beta multiple interactions EXP Losartan inhibits the reaction [Ethanol results in increased expression of PRKCB protein] CTD PMID:22497828 NCBI chr 1:176,832,173...177,163,539 JBrowse link
G Prl prolactin multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased secretion of PRL protein] CTD PMID:14722030 NCBI chr17:37,859,999...37,870,062 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
EXP
ISO
Losartan inhibits the reaction [[AGT protein binds to and results in increased localization of AGTR1A protein] which results in increased expression of PTGS2 protein]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 mRNA]; Losartan inhibits the reaction [Phenylephrine results in increased expression of PTGS2 protein]
Losartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
Losartan results in decreased expression of PTGS2 mRNA; Losartan results in decreased expression of PTGS2 protein
CTD PMID:17244722 PMID:18267125 PMID:21377515 PMID:28578904 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP Losartan inhibits the reaction [Folic Acid results in decreased expression of PTH1R protein]; Losartan inhibits the reaction [Gentamicins results in decreased expression of PTH1R protein] CTD PMID:15728788 NCBI chr 8:110,693,910...110,725,458 JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH mRNA]; Losartan inhibits the reaction [Folic Acid results in increased expression of PTHLH protein]; Losartan inhibits the reaction [Gentamicins results in increased expression of PTHLH protein] CTD PMID:15728788 NCBI chr 4:180,188,792...180,199,847 JBrowse link
G Reg3g regenerating family member 3 gamma multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of REG3G mRNA] CTD PMID:27798352 NCBI chr 4:110,922,805...110,927,803 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
Losartan inhibits the reaction [Doxorubicin results in increased expression of RELA mRNA]
Losartan inhibits the reaction [AGT protein results in increased expression of RELA protein]; Losartan inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of RELA protein]
CTD PMID:15157388 PMID:28578904 PMID:29859236 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Ren renin multiple interactions
increases expression
increases activity
ISO
EXP
[Losartan results in decreased activity of AGTR1 protein] which results in increased expression of REN protein; Losartan inhibits the reaction [AGT protein results in increased expression of REN protein]; Losartan promotes the reaction [Hydrochlorothiazide results in increased expression of REN protein]
Losartan inhibits the reaction [AGT protein results in increased expression of REN1 protein]
Losartan results in increased expression of REN mRNA; Losartan results in increased expression of REN protein
Losartan results in increased activity of REN protein
[Lisinopril co-treated with Losartan] results in increased expression of REN mRNA; Losartan inhibits the reaction [Ethanol results in increased activity of REN protein]; Losartan promotes the reaction [Isoproterenol results in increased expression of REN protein]
CTD PMID:1387008 PMID:7965263 PMID:8382237 PMID:8403307 PMID:9124547 PMID:9245700 PMID:9431853 PMID:9533614 PMID:11709406 PMID:12013499 PMID:12569265 PMID:16221218 PMID:22982071 PMID:28578904 NCBI chr13:44,796,260...44,807,491 JBrowse link
G RT1-Da RT1 class II, locus Da decreases expression EXP Losartan results in decreased expression of RT1-DA mRNA CTD PMID:15100363 NCBI chr20:4,513,464...4,518,457 JBrowse link
G RT1-S3 RT1 class Ib, locus S3 decreases expression EXP Losartan results in decreased expression of RT1-S3 mRNA CTD PMID:15100363 NCBI chr20:2,670,654...2,675,411 JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions EXP Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 mRNA]; Losartan affects the reaction [[Warfarin co-treated with Vitamin K 1] affects the expression of RUNX2 protein] CTD PMID:27412937 NCBI chr 9:16,167,504...16,492,826 JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO [Losartan co-treated with ICG 001] inhibits the reaction [AGT protein results in increased expression of S100A4 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of S100A4 protein] CTD PMID:28578904 NCBI chr 2:176,090,951...176,093,258 JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 mRNA]; Losartan inhibits the reaction [AGT protein modified form results in increased expression of S1PR1 protein] CTD PMID:29609002 NCBI chr 2:203,624,752...203,629,110 JBrowse link
G Scarb1 scavenger receptor class B, member 1 multiple interactions ISO Losartan inhibits the reaction [[Dietary Fats co-treated with Cholesterol] results in decreased expression of SCARB1 mRNA] CTD PMID:18302760 NCBI chr12:31,296,143...31,362,649 JBrowse link
G Sdc2 syndecan 2 decreases expression EXP Losartan results in decreased expression of SDC2 mRNA; Losartan results in decreased expression of SDC2 protein CTD PMID:15100363 NCBI chr 7:64,127,185...64,239,885 JBrowse link
G Selp selectin P multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of SELP protein] CTD PMID:19553526 NCBI chr13:76,476,229...76,511,846 JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases response to substance EXP SFRP2 protein results in decreased susceptibility to Losartan CTD PMID:23875703 NCBI chr 2:169,089,517...169,097,064 JBrowse link
G Slc22a12 solute carrier family 22 member 12 decreases activity
affects response to substance
decreases expression
multiple interactions
ISO Losartan results in decreased activity of SLC22A12 protein
SLC22A12 protein affects the susceptibility to Losartan
Losartan results in decreased expression of SLC22A12 mRNA
[Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid
CTD PMID:18670416 PMID:20486468 NCBI chr 1:203,845,039...203,852,496 JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Losartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:205,338,698...205,498,486 JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions ISO Losartan inhibits the reaction [SLC2A9 protein results in increased uptake of Uric Acid] CTD PMID:19587147 NCBI chr14:72,328,334...72,461,981 JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions ISO Losartan inhibits the reaction [Ammonium Chloride results in increased expression of NHE3 protein] CTD PMID:18287403 NCBI chr 1:29,124,633...29,167,912 JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO ICG 001 promotes the reaction [Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]]; Losartan inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]; Losartan promotes the reaction [ICG 001 inhibits the reaction [AGT protein results in increased expression of SNAI1 protein]] CTD PMID:28578904 NCBI chr 3:156,248,479...156,252,969 JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP Losartan results in decreased activity of SOD2 protein CTD PMID:18765277 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of SOD3 protein] CTD PMID:10400907 NCBI chr14:58,610,104...58,615,845 JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression EXP Losartan results in decreased expression of SPARC mRNA CTD PMID:15100363 NCBI chr10:39,516,394...39,538,252 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Losartan inhibits the reaction [AGT protein results in increased expression of SREBF1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased phosphorylation of SREBF1 protein] CTD PMID:19109942 PMID:25398788 NCBI chr10:45,007,637...45,029,650 JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Losartan results in decreased phosphorylation of STAT3 protein CTD PMID:33380422 NCBI chr10:85,811,206...85,863,057 JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases secretion
multiple interactions
decreases activity
decreases expression
increases expression
ISO
EXP
Losartan results in decreased secretion of TGFB1 protein
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TGFB1 protein]
[Losartan results in decreased activity of AGT protein] which results in decreased activity of TGFB1 protein
Losartan results in decreased expression of TGFB1 mRNA; Losartan results in decreased expression of TGFB1 protein
Losartan results in increased expression of TGFB1 protein
[Losartan co-treated with Cilazapril] inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; [Losartan co-treated with Nifedipine] results in decreased expression of TGFB1 mRNA; Losartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TGFB1 protein]; Losartan inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Losartan inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
CTD PMID:11369837 PMID:12930639 PMID:12937228 PMID:15331931 PMID:15573910 PMID:16191423 PMID:17330452 PMID:17666919 PMID:17784886 PMID:21152098 PMID:25233898 PMID:29859236 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
EXP Losartan inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP1 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP1 mRNA] CTD PMID:20137537 PMID:25233898 NCBI chr  X:1,212,969...1,217,714 JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression
multiple interactions
EXP Losartan results in decreased expression of TIMP2 mRNA
Losartan inhibits the reaction [Simvastatin results in decreased expression of TIMP2 mRNA]; Simvastatin inhibits the reaction [Losartan results in decreased expression of TIMP2 mRNA]
CTD PMID:20137537 NCBI chr10:103,541,199...103,590,611 JBrowse link
G Tjp1 tight junction protein 1 decreases expression EXP Losartan results in decreased expression of TJP1 protein CTD PMID:18400868 NCBI chr 1:118,849,838...119,094,492 JBrowse link
G Tnc tenascin C decreases expression EXP Losartan results in decreased expression of TNC mRNA CTD PMID:15100363 NCBI chr 5:77,375,851...77,460,712 JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Losartan affects the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Losartan inhibits the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]; Losartan inhibits the reaction [AGT protein modified form promotes the reaction [[Shiga Toxin 1 co-treated with TNF protein] results in increased activity of F3 protein]]; Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; T 0070907 inhibits the reaction [Losartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of TNF protein]
Losartan results in decreased expression of TNF protein
Losartan inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Losartan inhibits the reaction [Carbon Tetrachloride results in increased secretion of TNF protein]
CTD PMID:15573910 PMID:17299153 PMID:18060435 PMID:22124178 PMID:23875703 PMID:29859236 PMID:30677511 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 decreases expression EXP Losartan results in decreased expression of TOMM20 mRNA CTD PMID:18765277 NCBI chr19:54,925,197...54,935,188 JBrowse link
G Tp53 tumor protein p53 affects expression EXP Losartan affects the expression of TP53 protein CTD PMID:22000973 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Tsc22d1 TSC22 domain family, member 1 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of TSC22D1 mRNA] CTD PMID:26464165 NCBI chr15:51,750,489...51,850,958 JBrowse link
G Twist1 twist family bHLH transcription factor 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of TWIST1 protein] CTD PMID:28578904 NCBI chr 6:50,674,910...50,676,904 JBrowse link
G Ucp2 uncoupling protein 2 decreases expression
multiple interactions
ISO
EXP
Losartan results in decreased expression of UCP2 mRNA; Losartan results in decreased expression of UCP2 protein
Losartan inhibits the reaction [AGT protein results in increased expression of UCP2 mRNA]
CTD PMID:17508912 PMID:19109942 NCBI chr 1:154,839,242...154,845,612 JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions EXP Losartan inhibits the reaction [AGT protein results in increased expression of UCP3 mRNA] CTD PMID:19109942 NCBI chr 1:154,815,777...154,828,764 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP Losartan inhibits the reaction [Estrogens deficiency results in increased expression of VCAM1 protein] CTD PMID:19553526 NCBI chr 2:204,038,120...204,057,852 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO
EXP
Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [IL1A protein results in increased expression of VEGFA protein]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; Losartan inhibits the reaction [TNF protein results in increased expression of VEGFA protein]; Losartan promotes the reaction [AGT protein results in increased expression of VEGFA mRNA]; Losartan promotes the reaction [AGT protein results in increased secretion of VEGFA protein]
Losartan inhibits the reaction [Diethylnitrosamine results in increased expression of VEGFA protein]; Losartan inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
Losartan inhibits the reaction [Cyclosporine results in increased expression of VEGFA protein]
Losartan results in decreased expression of VEGFA mRNA; Losartan results in decreased expression of VEGFA protein
CTD PMID:12110003 PMID:17299153 PMID:17481528 PMID:22188725 PMID:25511041 PMID:29859236 NCBI chr 9:14,955,300...14,970,641 JBrowse link
G Vegfc vascular endothelial growth factor C decreases expression ISO Losartan results in decreased expression of VEGFC mRNA CTD PMID:19771429 NCBI chr16:37,712,408...37,827,657 JBrowse link
G Vim vimentin multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]
Losartan inhibits the reaction [AGT protein results in increased expression of VIM protein]; Losartan inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein]
CTD PMID:28578904 PMID:33007385 NCBI chr17:76,668,701...76,677,186 JBrowse link
G Wnt1 Wnt family member 1 multiple interactions ISO Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 mRNA]; Losartan inhibits the reaction [AGT protein results in increased expression of WNT1 protein] CTD PMID:28578904 NCBI chr 7:129,938,604...129,942,651 JBrowse link
G Wt1 WT1 transcription factor multiple interactions ISO Losartan inhibits the reaction [AGT protein results in decreased expression of WT1 protein] CTD PMID:28578904 NCBI chr 3:91,566,540...91,613,653 JBrowse link
losartan carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO losartan carboxylic acid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:205,338,698...205,498,486 JBrowse link
olmesartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO olmesartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
olmesartan results in decreased activity of ABCB11 protein
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects transport ISO ABCC2 protein affects the transport of olmesartan CTD PMID:19505989 NCBI chr 1:242,664,657...242,723,239 JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression EXP olmesartan results in increased expression of ACE2 mRNA; olmesartan results in increased expression of ACE2 protein CTD PMID:19171689 PMID:28656296 NCBI chr  X:30,293,597...30,340,961 JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]] CTD PMID:24144775 NCBI chr 1:231,746,527...231,759,307 JBrowse link
G Agt angiotensinogen decreases expression
multiple interactions
EXP
ISO
olmesartan results in decreased expression of AGT protein modified form
[olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]
CTD PMID:16003179 PMID:19171689 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases activity ISO olmesartan results in decreased activity of AGTR1 protein CTD PMID:17208988 NCBI chr17:34,173,446...34,226,892 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [Pravastatin co-treated with olmesartan] results in increased phosphorylation of AKT1 protein CTD PMID:17170375 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Alb albumin decreases oxidation ISO olmesartan results in decreased oxidation of ALB protein CTD PMID:17587751 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO olmesartan results in decreased expression of BAX protein CTD PMID:17208988 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Casp3 caspase 3 multiple interactions ISO olmesartan results in decreased expression of and results in decreased activity of CASP3 protein CTD PMID:17208988 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Crp C-reactive protein decreases expression ISO olmesartan results in decreased expression of CRP protein CTD PMID:18360012 NCBI chr13:85,131,635...85,175,179 JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP olmesartan results in decreased expression of CYBA protein CTD PMID:17170375 NCBI chr19:50,487,598...50,495,669 JBrowse link
G Daxx death-domain associated protein decreases expression ISO olmesartan results in decreased expression of DAXX protein CTD PMID:17208988 NCBI chr20:4,970,090...4,976,145 JBrowse link
G Dhfr dihydrofolate reductase increases expression EXP olmesartan results in increased expression of DHFR protein CTD PMID:17170375 NCBI chr 2:23,585,876...23,611,199 JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO olmesartan results in decreased expression of FAS protein CTD PMID:17208988 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Il18 interleukin 18 multiple interactions EXP olmesartan inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] CTD PMID:18660453 NCBI chr 8:50,904,630...50,932,887 JBrowse link
G Il6 interleukin 6 decreases expression ISO olmesartan results in decreased expression of IL6 protein CTD PMID:18360012 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases activity ISO olmesartan results in decreased activity of JUN protein CTD PMID:17208988 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression ISO olmesartan results in increased expression of MAPK1 protein modified form CTD PMID:17208988 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO olmesartan results in increased expression of MAPK3 protein modified form CTD PMID:17208988 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
decreases activity
ISO olmesartan results in decreased expression of MAPK8 protein modified form
olmesartan results in decreased activity of MAPK8 protein
CTD PMID:17208988 NCBI chr16:8,638,897...8,721,960 JBrowse link
G Mapk9 mitogen-activated protein kinase 9 decreases expression
decreases activity
ISO olmesartan results in decreased expression of MAPK9 protein modified form
olmesartan results in decreased activity of MAPK9 protein
CTD PMID:17208988 NCBI chr10:34,169,661...34,211,138 JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor increases expression EXP olmesartan results in increased expression of MAS1 mRNA; olmesartan results in increased expression of MAS1 protein CTD PMID:28656296 NCBI chr 1:47,879,956...47,911,500 JBrowse link
G Mpo myeloperoxidase multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]] CTD PMID:24144775 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP olmesartan promotes the reaction [NOS3 protein binds to NOS3 protein]; olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein; Pravastatin promotes the reaction [olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein] CTD PMID:17170375 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin increases expression ISO Olmesartan increases expression of Nphs1 protein in kidney RGD PMID:17229913 RGD:38599164 NCBI chr 1:85,720,812...85,749,079 JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]] CTD PMID:24144775 NCBI chr18:54,500,002...54,538,843 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]] CTD PMID:24144775 NCBI chr 1:81,196,532...81,212,848 JBrowse link
PD123319 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP PD 123319 inhibits the reaction [diminazene aceturate results in increased expression of ACE2 protein] CTD PMID:28688122 NCBI chr  X:30,293,597...30,340,961 JBrowse link
G Agt angiotensinogen multiple interactions
decreases response to substance
decreases activity
ISO
EXP
[olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased abundance of Fatty Acids, Nonesterified]; [olmesartan co-treated with PD 123319] inhibits the reaction [AGT protein modified form results in increased secretion of and results in increased abundance of Triglycerides]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein]
PD 123319 results in decreased susceptibility to AGT protein
PD 123319 results in decreased activity of AGT protein modified form
PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; PD 123319 inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 promotes the reaction [AGT protein results in increased abundance of Prostaglandins E]
PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
CTD PMID:9176287 PMID:9519251 PMID:11115077 PMID:14597853 PMID:14638905 PMID:14718351 PMID:15007106 PMID:16003179 PMID:16769992 PMID:17068200 PMID:18206046 PMID:18300857 PMID:19041135 PMID:19246637 PMID:25446015 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Agtr2 angiotensin II receptor, type 2 multiple interactions
decreases activity
increases expression
decreases expression
ISO
EXP
[PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein]; PD 123319 binds to and results in decreased activity of AGTR2 protein
PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [[AGT protein co-treated with Rotenone] results in increased expression of AGTR2 protein]]; PD 123319 inhibits the reaction [CGP 42112A promotes the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTR2 mRNA]]]
PD 123319 results in decreased activity of AGTR2 protein
PD 123319 results in increased expression of AGTR2 mRNA; PD 123319 results in increased expression of AGTR2 protein
PD 123319 results in decreased expression of AGTR2 mRNA
[PD 123319 binds to and results in decreased activity of AGTR2 protein] which affects the susceptibility to Phenylephrine; [PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Estradiol; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; PD 123319 binds to and results in decreased activity of AGTR2 protein
CTD PMID:9336375 PMID:9740612 PMID:11509473 PMID:11893553 PMID:15807884 PMID:16982965 PMID:18300857 PMID:18388195 PMID:18551021 PMID:19151255 PMID:25446015 NCBI chr  X:112,119,673...112,124,060 JBrowse link
G Agtrap angiotensin II receptor-associated protein multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP mRNA]]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [AGT protein promotes the reaction [Rotenone results in increased expression of AGTRAP protein]]] CTD PMID:25446015 NCBI chr 5:158,507,427...158,519,036 JBrowse link
G Angpt1 angiopoietin 1 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA] CTD PMID:14638905 NCBI chr 7:73,528,345...73,783,953 JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] CTD PMID:14638905 NCBI chr16:71,088,364...71,138,805 JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO PD 123319 affects the reaction [BDKRB2 affects the abundance of 6-Ketoprostaglandin F1 alpha] CTD PMID:16514058 NCBI chr 6:124,472,317...124,502,497 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP PD 123319 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] CTD PMID:15284299 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of CCL5 protein] CTD PMID:16284884 NCBI chr10:68,322,826...68,327,365 JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX2 protein]] CTD PMID:25446015 NCBI chr  X:13,360,583...13,392,517 JBrowse link
G Edn1 endothelin 1 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of EDN1 protein] CTD PMID:15007106 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO PD123319 co-treated with losartan inhibits the reaction [Angiotensin II increases phosphorylation of JAK2 protein in liver] RGD PMID:22613986 RGD:127285667 NCBI chr 1:226,995,334...227,054,381 JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 NCBI chr14:32,217,871...32,261,018 JBrowse link
G Kng2 kininogen 2 multiple interactions EXP
ISO
PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]
PD 123319 affects the reaction [KNG1 affects the abundance of Nitric Oxide]
CTD PMID:11509473 PMID:16514058 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of MAP2 protein] CTD PMID:17068200 NCBI chr 9:67,723,422...67,981,886 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19041135 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19041135 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of MDM2 protein] CTD PMID:18206046 NCBI chr 7:53,290,660...53,315,205 JBrowse link
G Mtus1 microtubule associated scaffold protein 1 multiple interactions EXP PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr16:51,202,497...51,347,791 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP PD 123319 inhibits the reaction [Ethylene Glycol results in increased expression of NFKB1 protein] CTD PMID:16284884 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [PD 123319 binds to and results in decreased activity of AGTR2 protein] inhibits the reaction [candesartan results in increased expression of NOS3 protein] CTD PMID:18551021 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Nox1 NADPH oxidase 1 multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 mRNA]]; PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX1 protein]] CTD PMID:25446015 NCBI chr  X:97,279,058...97,332,291 JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO PD 123319 inhibits the reaction [CGP 42112A inhibits the reaction [[AGT protein co-treated with Rotenone] results in increased expression of NOX4 mRNA]] CTD PMID:25446015 NCBI chr 1:140,900,886...141,078,844 JBrowse link
G Prkce protein kinase C, epsilon increases expression EXP PD 123319 results in increased expression of PRKCE protein CTD PMID:11893553 NCBI chr 6:7,965,048...8,451,966 JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 multiple interactions EXP PD 123319 affects the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr 4:157,526,034...157,550,783 JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 NCBI chr14:5,308,885...5,315,120 JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of TEK mRNA] CTD PMID:14638905 NCBI chr 5:109,607,077...109,733,805 JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of TUBB3 protein] CTD PMID:17068200 NCBI chr19:51,457,187...51,466,243 JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 multiple interactions ISO
EXP
PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of UBE2V2 protein] CTD PMID:16769992 PMID:17068200 NCBI chr11:85,304,528...85,338,430 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein] CTD PMID:14638905 PMID:14718351 NCBI chr 9:14,955,300...14,970,641 JBrowse link
telmisartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO telmisartan results in decreased activity of ABCB11 protein
telmisartan inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:20829430 PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797 JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions
increases expression
ISO PPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA] CTD PMID:22124178 NCBI chr20:9,126,687...9,182,948 JBrowse link
G Ace angiotensin I converting enzyme decreases expression
multiple interactions
EXP Telmisartan results in decreased expression of ACE mRNA; Telmisartan results in decreased expression of ACE protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of ACE protein]
CTD PMID:19171132 PMID:25973029 PMID:29909460 PMID:31629013 NCBI chr10:90,910,316...90,930,437 JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions
decreases expression
increases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]
Telmisartan results in decreased expression of ACE2 mRNA; Telmisartan results in decreased expression of ACE2 protein
Telmisartan results in increased expression of ACE2 mRNA; Telmisartan results in increased expression of ACE2 protein
CTD PMID:21381899 PMID:25973029 PMID:28656296 PMID:29909460 PMID:31629013 NCBI chr  X:30,293,597...30,340,961 JBrowse link
G Ache acetylcholinesterase multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein] CTD PMID:23060470 NCBI chr12:19,407,359...19,413,713 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO telmisartan results in increased expression of ADIPOQ mRNA
telmisartan results in increased expression of ADIPOQ protein
CTD PMID:19730415 PMID:20555330 NCBI chr11:77,721,912...77,735,644 JBrowse link
G Agt angiotensinogen multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]
telmisartan results in decreased expression of AGT mRNA; telmisartan results in decreased expression of AGT protein
Telmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA]; Telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; Telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; Telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; Telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Iohexol results in increased expression of AGT protein]; Telmisartan inhibits the reaction [Pregabalin results in decreased expression of AGT protein]
CTD PMID:9533614 PMID:17620961 PMID:18487452 PMID:19171132 PMID:19289654 PMID:19292980 PMID:19452295 PMID:19706694 PMID:31629013 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects binding
decreases expression
multiple interactions
increases expression
EXP
ISO
telmisartan binds to AGTR1 protein
telmisartan results in decreased expression of AGTR1A mRNA
telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]
telmisartan binds to and results in decreased activity of AGTR1 protein
Telmisartan binds to and results in decreased activity of AGTR1 protein; Telmisartan inhibits the reaction [AGT protein results in increased expression of AGTR1A mRNA]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of AGTR1A protein]; Telmisartan inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
telmisartan results in increased expression of AGTR1 mRNA
CTD PMID:8220885 PMID:9533614 PMID:9728324 PMID:17620961 PMID:19171132 PMID:19706694 PMID:20888384 PMID:21381899 PMID:21557540 PMID:31629013 NCBI chr17:34,173,446...34,226,892 JBrowse link
G Agtr1b angiotensin II receptor, type 1b multiple interactions ISO telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA] CTD PMID:17620961 NCBI chr 2:102,844,969...102,920,232 JBrowse link
G Ahr aryl hydrocarbon receptor increases activity EXP Telmisartan results in increased activity of AHR protein CTD PMID:28728110 NCBI chr 6:52,234,089...52,271,568 JBrowse link
G Alb albumin affects expression ISO telmisartan affects the expression of ALB protein modified form CTD PMID:16671338 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Ang2 angiogenin, ribonuclease A family, member 2 multiple interactions EXP telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of ANG2 protein] CTD PMID:23750309 NCBI chr15:24,398,383...24,415,837 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA] CTD PMID:24831514 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of BCL2 mRNA] CTD PMID:24831514 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF protein] CTD PMID:23747572 NCBI chr 3:96,165,042...96,215,621 JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G multiple interactions
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1G mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1G mRNA] CTD PMID:19292980 NCBI chr10:79,354,998...79,422,960 JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions
decreases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; SB 203580 inhibits the reaction [telmisartan results in decreased expression of CACNA1H mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of CACNA1H mRNA] CTD PMID:19292980 NCBI chr10:14,390,104...14,448,204 JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Pyruvaldehyde results in increased cleavage of CASP3 protein]
Telmisartan results in decreased expression of CASP3 protein
Telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; Telmisartan inhibits the reaction [Diatrizoate results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Iohexol results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of and results in increased activity of CASP3 protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CASP3 mRNA]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of CASP3 protein]
CTD PMID:18565324 PMID:19452295 PMID:21620867 PMID:21819444 PMID:22750630 PMID:24831514 PMID:26439596 PMID:29909460 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Cat catalase multiple interactions EXP Telmisartan inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein] CTD PMID:23750309 PMID:26929000 NCBI chr 3:89,842,393...89,874,577 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]
telmisartan results in decreased expression of CCL2 protein
CTD PMID:17922026 PMID:22124178 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases response to substance ISO telmisartan results in decreased susceptibility to CCL5 protein CTD PMID:18158351 NCBI chr10:68,322,826...68,327,365 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression EXP telmisartan results in decreased expression of CCR2 mRNA CTD PMID:17922026 NCBI chr 8:123,734,465...123,742,483 JBrowse link
G Cd36 CD36 molecule increases expression
multiple interactions
ISO telmisartan results in increased expression of CD36 mRNA
PPARG mutant form inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]; T 0070907 inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]
CTD PMID:22124178 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions EXP telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]] CTD PMID:19289654 NCBI chr 3:156,398,035...156,399,466 JBrowse link
G Crp C-reactive protein decreases expression ISO telmisartan results in decreased expression of CRP protein CTD PMID:20555330 NCBI chr13:85,131,635...85,175,179 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions
decreases response to substance
ISO PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]; telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]
telmisartan results in decreased susceptibility to CXCL12 protein
CTD PMID:18158351 NCBI chr 4:150,388,326...150,401,173 JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions
ISO
EXP
telmisartan results in decreased expression of CYBA mRNA; telmisartan results in decreased expression of CYBA protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of CYBA protein]
CTD PMID:16141465 PMID:19171132 PMID:21054405 NCBI chr19:50,487,598...50,495,669 JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of CYBB protein]
telmisartan results in decreased expression of CYBB mRNA
CTD PMID:19171132 PMID:21381899 NCBI chr  X:13,360,583...13,392,517 JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CYCS mRNA] CTD PMID:24831514 NCBI chr 4:79,651,894...79,653,994 JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases activity ISO Telmisartan results in decreased activity of CYP2J2 protein CTD PMID:30965050 NCBI chr 5:111,179,981...111,207,490 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression EXP telmisartan results in decreased expression of DDIT3 protein CTD PMID:19102871 NCBI chr 7:63,115,645...63,121,203 JBrowse link
G Edn1 endothelin 1 multiple interactions EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDN1 protein] CTD PMID:20888384 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein] CTD PMID:20888384 NCBI chr19:30,233,540...30,303,727 JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP telmisartan promotes the reaction [Daunorubicin results in increased expression of EDNRB protein] CTD PMID:20888384 NCBI chr15:80,640,839...80,672,115 JBrowse link
G Faslg Fas ligand multiple interactions ISO
EXP
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASL protein]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of FASLG protein]
CTD PMID:21620867 PMID:21819444 NCBI chr13:74,151,519...74,172,760 JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of FN1 protein] CTD PMID:19706694 NCBI chr 9:73,196,044...73,264,695 JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions ISO Telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF mRNA]; Telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of GDNF protein] CTD PMID:23747572 NCBI chr 2:56,893,992...56,919,935 JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GFAP protein]
Telmisartan results in decreased expression of GFAP protein
CTD PMID:23747572 PMID:29909460 NCBI chr10:87,852,891...87,861,631 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of GGT1 protein] CTD PMID:23750309 NCBI chr20:13,074,695...13,104,095 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein] CTD PMID:26929000 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Hgf hepatocyte growth factor increases expression ISO telmisartan results in increased expression of HGF mRNA CTD PMID:21479465 NCBI chr 4:18,673,736...18,745,582 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP telmisartan results in decreased expression of HSPA5 protein CTD PMID:19102871 NCBI chr 3:18,055,507...18,059,969 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of ICAM1 protein]
telmisartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]
CTD PMID:17724226 PMID:20888384 PMID:22124178 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Il10 interleukin 10 multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL10 protein]
Telmisartan results in increased expression of IL10 protein
CTD PMID:24831514 PMID:29909460 NCBI chr13:42,472,625...42,477,308 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:22124178 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Telmisartan results in decreased expression of IL6 protein
telmisartan results in decreased expression of IL6 mRNA
2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
telmisartan inhibits the reaction [AGT protein results in increased expression of IL6 protein]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
CTD PMID:19289654 PMID:21479465 PMID:22124178 PMID:29909460 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Ins2 insulin 2 decreases expression ISO telmisartan results in decreased expression of INS protein CTD PMID:15892894 NCBI chr 1:197,843,277...197,992,522 JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of IRAK1 mRNA CTD PMID:20524934 NCBI chr  X:151,768,621...151,778,521 JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions
increases expression
ISO PPARD promotes the reaction [telmisartan results in increased expression of LIPE protein] CTD PMID:20176998 NCBI chr 1:80,965,612...80,984,313 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22124178 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
decreases phosphorylation
ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK14 protein]
telmisartan results in decreased phosphorylation of MAPK14 protein
CTD PMID:19292980 PMID:22124178 NCBI chr20:6,749,646...6,810,590 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO telmisartan inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22124178 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 multiple interactions ISO telmisartan inhibits the reaction [Streptozocin results in increased expression of MAPKAPK2 protein modified form] CTD PMID:21381899 NCBI chr13:42,513,762...42,560,061 JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions
increases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in decreased expression of MAS1 protein]
Telmisartan inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]
Telmisartan results in increased expression of MAS1 protein
CTD PMID:21381899 PMID:28656296 PMID:31629013 NCBI chr 1:47,879,956...47,911,500 JBrowse link
G Mir146a microRNA 146a multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146A CTD PMID:20524934 NCBI chr10:27,848,516...27,848,610 JBrowse link
G Mir146b microRNA 146b multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of MIR146B CTD PMID:20524934 NCBI chr 1:245,203,438...245,203,525 JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression EXP telmisartan results in decreased expression of MMP2 protein CTD PMID:21054405 NCBI chr19:14,154,657...14,182,870 JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]]; telmisartan inhibits the reaction [Streptozocin results in increased activity of MPO protein]
Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased activity of MPO protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD PMID:23060470 PMID:24831514 PMID:26439596 PMID:26929000 NCBI chr10:72,594,458...72,608,862 JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF1 protein]
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF1 protein]
Telmisartan results in decreased expression of NCF1 mRNA; Telmisartan results in decreased expression of NCF1 protein
telmisartan results in decreased expression of NCF1 mRNA; telmisartan results in decreased expression of NCF1 protein
CTD PMID:16141465 PMID:19171132 PMID:21054405 PMID:21381899 NCBI chr12:22,485,382...22,494,647 JBrowse link
G Ncf2 neutrophil cytosolic factor 2 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of NCF2 protein]
telmisartan results in decreased expression of NCF2 mRNA; telmisartan results in decreased expression of NCF2 protein
telmisartan inhibits the reaction [Daunorubicin results in increased expression of NCF2 protein]
CTD PMID:16141465 PMID:21054405 PMID:21381899 NCBI chr13:64,955,502...64,986,289 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NFKB1 protein] CTD PMID:21620867 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA] CTD PMID:22124178 NCBI chr 6:72,858,713...72,861,941 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2 protein]
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of NOS2 protein]; telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of NOS2]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]
CTD PMID:21620867 PMID:21819444 PMID:22750630 PMID:24831514 PMID:26439596 PMID:26929000 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
increases expression
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased expression of NOS3 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in increased phosphorylation of NOS3 protein] CTD PMID:21156825 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of NOX4 protein] CTD PMID:21054405 NCBI chr 1:140,900,886...141,078,844 JBrowse link
G Nppb natriuretic peptide B affects expression
multiple interactions
decreases expression
ISO
EXP
telmisartan affects the expression of NPPB protein
Telmisartan inhibits the reaction [Pregabalin results in increased expression of NPPB protein]
telmisartan results in decreased expression of NPPB protein
CTD PMID:16671338 PMID:18712048 PMID:31629013 NCBI chr 5:158,416,813...158,418,175 JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 mRNA]; Telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of OLR1 protein] CTD PMID:22124178 NCBI chr 4:162,926,436...162,949,057 JBrowse link
G Plau plasminogen activator, urokinase multiple interactions EXP telmisartan inhibits the reaction [AGT protein results in decreased expression of PLAU mRNA] CTD PMID:19706694 NCBI chr15:3,456,230...3,462,732 JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression
multiple interactions
EXP
ISO
telmisartan results in increased expression of PPARD protein
PPARD promotes the reaction [telmisartan results in increased expression of LIPE protein]; PPARD promotes the reaction [telmisartan results in increased expression of UCP1 protein]; PPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein]; PPARD promotes the reaction [telmisartan results in increased expression of UCP3 protein]
CTD PMID:20176998 NCBI chr20:6,298,785...6,363,970 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression
increases activity
ISO
EXP
PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]]; PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; PPARG mutant form inhibits the reaction [telmisartan results in increased expression of ABCG1 mRNA]; PPARG mutant form inhibits the reaction [telmisartan results in increased expression of CD36 mRNA]; PPARG protein promotes the reaction [telmisartan inhibits the reaction [CXCL12 protein affects the localization of ICAM3 protein]]
telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of PPARG mRNA]; telmisartan promotes the reaction [Daunorubicin results in increased expression of PPARG protein]
telmisartan results in increased expression of PPARG protein
telmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARG protein]
Telmisartan results in increased activity of PPARG protein
CTD PMID:18158351 PMID:20176998 PMID:20888384 PMID:21381899 PMID:22124178 PMID:24831514 PMID:28728110 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO telmisartan inhibits the reaction [Streptozocin results in decreased expression of PPARGC1A protein] CTD PMID:21381899 NCBI chr14:58,860,752...59,516,525 JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Telmisartan inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr19:24,155,081...24,178,430 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
[Telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [Daunorubicin results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]
CTD PMID:20223228 PMID:20888384 PMID:22124178 PMID:22750630 PMID:24831514 PMID:26439596 PMID:26929000 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions EXP telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTH1R protein] CTD PMID:23750309 NCBI chr 8:110,693,910...110,725,458 JBrowse link
G Pthlh parathyroid hormone-like hormone multiple interactions EXP telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of PTHLH protein] CTD PMID:23750309 NCBI chr 4:180,188,792...180,199,847 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
[telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of RELA protein]; telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA mRNA]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of RELA protein]
telmisartan inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
CTD PMID:20223228 PMID:22124178 PMID:24831514 PMID:26929000 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Ren renin increases expression EXP telmisartan results in increased expression of REN mRNA; telmisartan results in increased expression of REN protein CTD PMID:9533614 NCBI chr13:44,796,260...44,807,491 JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 increases activity ISO telmisartan results in increased activity of SCN5A protein CTD PMID:29306026 NCBI chr 8:119,220,905...119,318,816 JBrowse link
G Sema3b semaphorin 3B multiple interactions ISO telmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3B protein]; telmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3B protein] CTD PMID:21933904 NCBI chr 8:108,271,663...108,280,326 JBrowse link
G Sema3f semaphorin 3F multiple interactions ISO telmisartan inhibits the reaction [Calcitriol results in increased expression of SEMA3F protein]; telmisartan inhibits the reaction [Progesterone results in increased expression of SEMA3F protein] CTD PMID:21933904 NCBI chr 8:108,357,629...108,387,083 JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO
EXP
telmisartan inhibits the reaction [[AGT protein modified form co-treated with AGTR1A co-treated with AGTR1B] results in increased expression of SERPINE1 mRNA]; telmisartan inhibits the reaction [Hydrogen Peroxide results in increased expression of SERPINE1 mRNA]
telmisartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]
CTD PMID:17620961 PMID:19706694 NCBI chr12:19,601,272...19,611,657 JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC18A2 protein] CTD PMID:23747572 NCBI chr 1:258,413,748...258,449,143 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO telmisartan inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268 JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC6A3 protein] CTD PMID:23747572 NCBI chr 1:29,709,443...29,750,413 JBrowse link
G Snca synuclein alpha multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of SNCA protein] CTD PMID:23747572 NCBI chr 4:89,696,420...89,797,240 JBrowse link
G Syp synaptophysin multiple interactions ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
telmisartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; telmisartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]
CTD PMID:18487452 NCBI chr  X:14,849,444...14,864,553 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]
telmisartan results in decreased expression of TGFB1 mRNA
telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 mRNA]; telmisartan inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; telmisartan inhibits the reaction [Daunorubicin results in increased expression of TGFB1 protein]
CTD PMID:19171132 PMID:19706694 PMID:20888384 PMID:21381899 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH mRNA]; telmisartan inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:23747572 NCBI chr 1:198,071,500...198,078,832 JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
affects localization
ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan affects the localization of TJP1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]; wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]
telmisartan results in decreased expression of TJP1 mRNA; telmisartan results in decreased expression of TJP1 protein
CTD PMID:19252288 NCBI chr 1:118,849,838...119,094,492 JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 mRNA; [Atorvastatin co-treated with Telmisartan] results in decreased expression of TLR4 protein CTD PMID:20524934 NCBI chr 5:80,145,867...80,159,501 JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
PPARG mutant form inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; T 0070907 inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; T 0070907 inhibits the reaction [telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; telmisartan inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
Telmisartan results in decreased expression of TNF protein
telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; [telmisartan co-treated with Aspirin] inhibits the reaction [Streptozocin results in increased expression of TNF protein]; telmisartan inhibits the reaction [Cadmium Chloride results in increased expression of TNF]; telmisartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; telmisartan inhibits the reaction [sodium arsenite results in increased expression of TNF]; telmisartan inhibits the reaction [TNF protein promotes the reaction [CEBPB protein binds to IL6 promoter]]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; telmisartan inhibits the reaction [TNF protein results in increased expression of IL6 protein]; telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
CTD PMID:19289654 PMID:20223228 PMID:21620867 PMID:21819444 PMID:22124178 PMID:22750630 PMID:24831514 PMID:26439596 PMID:26929000 PMID:29909460 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO [Atorvastatin co-treated with Telmisartan] results in decreased expression of TRAF6 mRNA CTD PMID:20524934 NCBI chr 3:87,963,517...87,988,316 JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions
increases expression
ISO PPARD promotes the reaction [telmisartan results in increased expression of UCP1 protein] CTD PMID:20176998 NCBI chr19:24,808,782...24,816,853 JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions
increases expression
ISO PPARD promotes the reaction [telmisartan results in increased expression of UCP2 protein] CTD PMID:20176998 NCBI chr 1:154,839,242...154,845,612 JBrowse link
G Ucp3 uncoupling protein 3 multiple interactions
increases expression
ISO PPARD promotes the reaction [telmisartan results in increased expression of UCP3 protein] CTD PMID:20176998 NCBI chr 1:154,815,777...154,828,764 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP telmisartan inhibits the reaction [Daunorubicin results in increased expression of VCAM1 protein] CTD PMID:20888384 NCBI chr 2:204,038,120...204,057,852 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO
EXP
telmisartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]
telmisartan inhibits the reaction [sodium arsenite results in increased expression of VEGFA]
telmisartan results in decreased expression of VEGFA mRNA
CTD PMID:17724226 PMID:19171132 PMID:26439596 NCBI chr 9:14,955,300...14,970,641 JBrowse link
valsartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases expression
EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein]
Valsartan results in decreased expression of ACE mRNA
CTD PMID:23733546 PMID:31023080 NCBI chr10:90,910,316...90,930,437 JBrowse link
G Ace2 angiotensin I converting enzyme 2 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA] CTD PMID:16176966 NCBI chr  X:30,293,597...30,340,961 JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA] CTD PMID:19225232 NCBI chr11:24,932,227...24,941,068 JBrowse link
G Agt angiotensinogen multiple interactions
increases expression
ISO
EXP
[benazepril co-treated with Valsartan] results in decreased expression of AGT protein modified form; [Valsartan co-treated with benidipine] inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein]; Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Aldosterone]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ADAMTS1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]; Valsartan inhibits the reaction [benazepril results in decreased expression of AGT protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]]
Valsartan results in increased expression of AGT protein; Valsartan results in increased expression of AGT protein modified form
Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein]; Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [AGT protein results in decreased export of Sodium]; Valsartan inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Oxygen]; Valsartan inhibits the reaction [AGT protein results in increased abundance of Prostaglandins E]; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [AGT protein results in increased secretion of Nitric Oxide]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of AGT protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]]; Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Glucose results in increased expression of AGT protein]; Valsartan promotes the reaction [Particulate Matter results in increased expression of AGT protein modified form]
[Valsartan co-treated with AGT protein] results in increased activity of LPL protein; Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]
CTD PMID:9261183 PMID:10082498 PMID:11115077 PMID:11244025 PMID:11403356 PMID:11501062 PMID:11897773 PMID:12676074 PMID:12846741 PMID:14597645 PMID:14597853 PMID:14620932 PMID:14638905 PMID:14718351 PMID:15005273 PMID:15504291 PMID:15539634 PMID:15643130 PMID:15677497 PMID:15831366 PMID:16176966 PMID:16705055 PMID:16769992 PMID:17068200 PMID:17485602 PMID:17785354 PMID:18331727 PMID:18390891 PMID:18487452 PMID:18619357 PMID:18640387 PMID:18716376 PMID:18846332 PMID:19041135 PMID:19145780 PMID:19225232 PMID:19246637 PMID:19861503 PMID:20175999 PMID:20718632 PMID:23288202 PMID:23300732 NCBI chr19:52,529,139...52,549,618 JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression
multiple interactions
EXP
ISO
Valsartan results in decreased expression of AGTR1A mRNA
Valsartan binds to and results in decreased activity of AGTR1 protein
CTD PMID:18403896 PMID:28973481 NCBI chr17:34,173,446...34,226,892 JBrowse link
G Agtr2 angiotensin II receptor, type 2 affects response to substance
increases expression
decreases expression
multiple interactions
ISO
EXP
AGTR2 affects the susceptibility to Valsartan
Valsartan results in increased expression of AGTR2 protein
Valsartan results in decreased expression of AGTR2 mRNA
[PD 123319 results in decreased activity of AGTR2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [PD 123319 results in decreased activity of AGTR2 protein] which results in decreased susceptibility to Valsartan; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of AGTR2 protein]
CTD PMID:11403356 PMID:12215461 PMID:16982965 PMID:18403896 NCBI chr  X:112,119,673...112,124,060 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein] CTD PMID:31009642 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Alb albumin multiple interactions
decreases export
EXP
ISO
Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of ALB protein]
Valsartan results in decreased export of ALB protein
CTD PMID:16872305 PMID:17664856 NCBI chr14:17,607,397...17,622,814 JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased activity of ALOX15 protein] CTD PMID:9261183 NCBI chr10:55,060,169...55,068,885 JBrowse link
G Ang angiogenin decreases expression ISO Valsartan results in decreased expression of ANG mRNA CTD PMID:22768174 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Angpt1 angiopoietin 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT1 protein] CTD PMID:14638905 NCBI chr 7:73,528,345...73,783,953 JBrowse link
G Angpt2 angiopoietin 2 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ANGPT2 mRNA] CTD PMID:14638905 NCBI chr16:71,088,364...71,138,805 JBrowse link
G Apcs amyloid P component, serum decreases expression ISO Valsartan results in decreased expression of APCS protein CTD PMID:16129801 NCBI chr13:85,373,338...85,374,134 JBrowse link
G Apob apolipoprotein B multiple interactions ISO [Valsartan co-treated with benazepril] results in decreased expression of APOB protein; fluvastatin promotes the reaction [[Valsartan co-treated with benazepril] results in decreased expression of APOB protein] CTD PMID:20671225 NCBI chr 6:30,844,386...30,883,983 JBrowse link
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein; Valsartan inhibits the reaction [AGT protein results in decreased expression of APOE protein] CTD PMID:17785354 PMID:19603250 NCBI chr 1:79,353,924...79,357,852 JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP Valsartan inhibits the reaction [Glucose results in increased expression of AQP1 mRNA] CTD PMID:11510275 NCBI chr 4:84,482,512...84,494,690 JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP Valsartan inhibits the reaction [Glucose results in increased expression of AQP4 mRNA] CTD PMID:11510275 NCBI chr18:6,507,903...6,524,558 JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 multiple interactions EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 protein] CTD PMID:18192338 NCBI chr  X:10,183,983...10,210,948 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BAX protein] CTD PMID:32197949 NCBI chr 1:95,940,001...95,945,407 JBrowse link
G Bbc3 Bcl-2 binding component 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BBC3 mRNA] CTD PMID:32197949 NCBI chr 1:77,013,281...77,022,509 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 protein] CTD PMID:32197949 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of BCL2L11 mRNA] CTD PMID:32197949 NCBI chr 3:115,366,783...115,404,068 JBrowse link
G Bdkrb1 bradykinin receptor B1 multiple interactions EXP [bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [bradykinin, Leu(8)-des-Arg(9)- results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Valsartan CTD PMID:16982965 NCBI chr 6:124,510,827...124,514,475 JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions EXP [icatibant results in decreased activity of BDKRB2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Valsartan CTD PMID:16982965 NCBI chr 6:124,472,317...124,502,497 JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of BMP4 mRNA] CTD PMID:19225232 NCBI chr15:19,618,538...19,633,494 JBrowse link
G Bmp7 bone morphogenetic protein 7 multiple interactions EXP Valsartan inhibits the reaction [Tacrolimus results in decreased expression of BMP7 protein] CTD PMID:17703430 NCBI chr 3:161,639,915...161,716,938 JBrowse link
G Casp3 caspase 3 multiple interactions EXP Valsartan inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; Valsartan inhibits the reaction [Cyclophosphamide results in increased activity of CASP3 protein] CTD PMID:23300732 PMID:32197949 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Casp4 caspase 4 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased cleavage of CASP4 protein] CTD PMID:32197949 NCBI chr 8:2,599,017...2,635,097 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO
EXP
[Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CCL2 protein]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of CCL2 mRNA]]; Valsartan inhibits the reaction [sodium arsenite results in increased secretion of CCL2 protein]
Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]
Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA]
CTD PMID:15284299 PMID:16705055 PMID:17624267 PMID:18436887 PMID:19225232 PMID:28973481 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Cd163 CD163 molecule decreases expression ISO Valsartan results in decreased expression of CD163 mRNA CTD PMID:22768174 NCBI chr 4:157,085,080...157,118,470 JBrowse link
G Cd34 CD34 molecule decreases expression ISO Valsartan results in decreased expression of CD34 mRNA CTD PMID:22768174 NCBI chr13:106,480,074...106,499,462 JBrowse link
G Cd68 Cd68 molecule decreases expression ISO Valsartan results in decreased expression of CD68 mRNA CTD PMID:22768174 NCBI chr10:54,381,814...54,383,693 JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of CDKN1B mRNA] CTD PMID:19225232 NCBI chr 4:167,760,067...167,765,177 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Valsartan results in decreased expression of CEBPA mRNA CTD PMID:22768174 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein] CTD PMID:31009642 NCBI chr10:79,883,622...79,900,625 JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL3A1 protein] CTD PMID:31009642 NCBI chr 9:47,374,611...47,410,547 JBrowse link
G Col4a4 collagen type IV alpha 4 chain multiple interactions ISO Valsartan inhibits the reaction [Streptozocin results in increased expression of COL4A4 mRNA] CTD PMID:33631230 NCBI chr 9:83,833,173...83,875,436 JBrowse link
G Crem cAMP responsive element modulator decreases expression EXP Valsartan results in decreased expression of CREM mRNA CTD PMID:19027736 NCBI chr17:54,238,889...54,305,989 JBrowse link
G Ctf1 cardiotrophin 1 multiple interactions EXP Dactinomycin promotes the reaction [Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of CTF1 protein] CTD PMID:23288202 NCBI chr 1:182,328,035...182,336,346 JBrowse link
G Ctss cathepsin S decreases expression ISO Valsartan results in decreased expression of CTSS mRNA CTD PMID:22768174 NCBI chr 2:183,089,192...183,114,483 JBrowse link
G Cxadr CXADR, Ig-like cell adhesion molecule decreases expression ISO Valsartan results in decreased expression of CXADR mRNA; Valsartan results in decreased expression of CXADR protein CTD PMID:20392896 NCBI chr11:16,982,752...17,030,078 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CXCL10 protein] CTD PMID:18716376 NCBI chr14:15,704,772...15,706,969 JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of CYBB protein] CTD PMID:15643130 NCBI chr  X:13,360,583...13,392,517 JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP Valsartan results in decreased expression of CYP11B2 mRNA; Valsartan results in decreased expression of CYP11B2 protein CTD PMID:16043663 NCBI chr 7:106,808,559...106,814,048 JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance ISO CYP3A5 gene affects the susceptibility to Valsartan CTD PMID:22149319 NCBI chr12:16,806,222...16,846,428 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 mRNA]; Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of DDIT3 protein] CTD PMID:32197949 NCBI chr 7:63,115,645...63,121,203 JBrowse link
G Des desmin multiple interactions EXP Valsartan inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:17624267 NCBI chr 9:76,850,979...76,858,695 JBrowse link
G Dusp5 dual specificity phosphatase 5 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of DUSP5 mRNA] CTD PMID:19225232 NCBI chr 1:252,538,408...252,555,320 JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of DYRK2 mRNA] CTD PMID:19225232 NCBI chr 7:54,348,724...54,381,363 JBrowse link
G Edn1 endothelin 1 multiple interactions EXP [Valsartan co-treated with benazepril] results in decreased expression of EDN1 protein CTD PMID:11136700 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Ednra endothelin receptor type A decreases expression EXP Valsartan results in decreased expression of EDNRA mRNA CTD PMID:28951255 NCBI chr19:30,233,540...30,303,727 JBrowse link
G Egr1 early growth response 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of EGR1 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of EGR1 mRNA]] CTD PMID:19225232 NCBI chr18:26,463,333...26,465,531 JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of EIF2AK3 protein] CTD PMID:32197949 NCBI chr 4:102,805,495...102,866,914 JBrowse link
G Elavl1 ELAV like RNA binding protein 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein affects the localization of ELAVL1 protein] CTD PMID:19246637 NCBI chr12:2,640,936...2,684,787 JBrowse link
G Eng endoglin multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of ENG mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of ENG protein] CTD PMID:15539634 NCBI chr 3:15,934,566...15,972,618 JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of ERN1 protein] CTD PMID:32197949 NCBI chr10:91,326,889...91,421,201 JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression ISO Valsartan results in decreased expression of FABP4 mRNA CTD PMID:22768174 NCBI chr 2:91,580,858...91,585,578 JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FAS protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FAS protein]] CTD PMID:15315341 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Faslg Fas ligand multiple interactions EXP benazepril promotes the reaction [Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]]; Valsartan inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]; Valsartan promotes the reaction [benazepril inhibits the reaction [Doxorubicin results in increased expression of FASLG protein]] CTD PMID:15315341 NCBI chr13:74,151,519...74,172,760 JBrowse link
G Fgf5 fibroblast growth factor 5 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FGF5 mRNA] CTD PMID:19225232 NCBI chr14:11,325,334...11,346,570 JBrowse link
G Filip1l filamin A interacting protein 1-like multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FILIP1L mRNA] CTD PMID:19225232 NCBI chr11:42,937,353...43,177,085 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of FOS mRNA] CTD PMID:18619357 PMID:18846332 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of FOSL1 mRNA] CTD PMID:19225232 NCBI chr 1:202,754,549...202,763,057 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of FSHB protein] CTD PMID:32197949 NCBI chr 3:93,548,560...93,552,370 JBrowse link
G Fzd2 frizzled class receptor 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of FZD2 mRNA] CTD PMID:19225232 NCBI chr10:87,561,866...87,563,776 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP
ISO
Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein] CTD PMID:31009642 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HBEGF mRNA] CTD PMID:19225232 NCBI chr18:28,106,284...28,116,167 JBrowse link
G Hdac2 histone deacetylase 2 multiple interactions EXP
ISO
Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of HDAC2 protein] CTD PMID:31009642 NCBI chr20:40,548,250...40,571,609 JBrowse link
G Hdac9 histone deacetylase 9 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HDAC9 mRNA] CTD PMID:19225232 NCBI chr 6:50,762,074...51,624,311 JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF mRNA]; Valsartan inhibits the reaction [Bleomycin results in decreased expression of HGF protein] CTD PMID:16115399 NCBI chr 4:18,673,736...18,745,582 JBrowse link
G Hivep1 HIVEP zinc finger 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of HIVEP1 mRNA] CTD PMID:19225232 NCBI chr17:22,585,016...22,714,517 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of HMOX1 protein] CTD PMID:32197949 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Valsartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]
Valsartan inhibits the reaction [sodium arsenite results in increased secretion of ICAM1 protein modified form]
CTD PMID:17724226 PMID:28973481 NCBI chr 8:19,553,063...19,565,438 JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of ID2 mRNA] CTD PMID:19225232 NCBI chr 6:41,740,556...41,742,393 JBrowse link
G Ier2 immediate early response 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of IER2 mRNA] CTD PMID:19225232 NCBI chr19:23,494,551...23,496,075 JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of IER3 mRNA] CTD PMID:19225232 NCBI chr20:2,928,378...2,929,582 JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Valsartan results in decreased expression of IL1B mRNA CTD PMID:28951255 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Tacrolimus co-treated with Valsartan] results in decreased expression of IL6 protein; [Tacrolimus co-treated with Valsartan] results in increased expression of IL6 protein CTD PMID:16549154 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Inhba inhibin subunit beta A multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of INHBA mRNA] CTD PMID:19225232 NCBI chr17:49,091,635...49,111,573 JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased phosphorylation of JAK2 protein]] CTD PMID:15677497 NCBI chr 1:226,995,334...227,054,381 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of JUN mRNA] CTD PMID:18619357 PMID:18846332 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased expression of KDR mRNA] CTD PMID:14638905 PMID:15005273 NCBI chr14:32,217,871...32,261,018 JBrowse link
G Kl Klotho increases expression EXP Valsartan results in increased expression of KL mRNA; Valsartan results in increased expression of KL protein CTD PMID:21051829 NCBI chr12:490,402...531,417 JBrowse link
G Klf10 Kruppel-like factor 10 multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of KLF10 mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of KLF10 mRNA]] CTD PMID:19225232 NCBI chr 7:69,467,658...69,473,726 JBrowse link
G Klf9 Kruppel-like factor 9 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of KLF9 mRNA] CTD PMID:19225232 NCBI chr 1:220,700,108...220,725,029 JBrowse link
G Kng2 kininogen 2 multiple interactions
increases expression
EXP benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]; PD 123319 inhibits the reaction [benazepril promotes the reaction [Valsartan results in increased expression of KNG1 protein modified form]]; PD 123319 inhibits the reaction [Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form]]; Valsartan promotes the reaction [benazepril results in increased expression of KNG1 protein modified form] CTD PMID:11509473 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased secretion of LHB protein] CTD PMID:32197949 NCBI chr 1:95,898,269...95,901,973 JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO [Valsartan co-treated with Simvastatin] inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]]; Valsartan inhibits the reaction [AGT protein results in increased expression of LIF mRNA]; Valsartan inhibits the reaction [Glucose promotes the reaction [AGT protein results in increased expression of LIF mRNA]] CTD PMID:19225232 NCBI chr14:79,131,049...79,140,486 JBrowse link
G Lpl lipoprotein lipase multiple interactions
increases activity
ISO [Valsartan co-treated with AGT protein] results in increased activity of LPL protein
Valsartan results in increased activity of LPL protein
CTD PMID:18640387 NCBI chr16:20,830,055...20,853,855 JBrowse link
G Maff MAF bZIP transcription factor F multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of MAFF mRNA] CTD PMID:19225232 NCBI chr 7:110,912,499...110,923,851 JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of MAP2 protein] CTD PMID:17068200 NCBI chr 9:67,723,422...67,981,886 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19041135 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19041135 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of MMP9 protein
Valsartan results in decreased expression of MMP9 mRNA; Valsartan results in decreased expression of MMP9 protein
CTD PMID:21051829 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mn1 MN1 proto-oncogene, transcriptional regulator multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of MN1 mRNA] CTD PMID:19225232 NCBI chr12:45,184,060...45,220,102 JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression ISO Valsartan results in decreased expression of MRC1 mRNA CTD PMID:22768174 NCBI chr17:77,249,187...77,330,857 JBrowse link
G Mtus1 microtubule associated scaffold protein 1 multiple interactions EXP Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr16:51,202,497...51,347,791 JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions
increases expression
EXP
ISO
[Valsartan co-treated with benazepril] results in increased expression of MYH6 mRNA
Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH6 protein]
Valsartan results in increased expression of MYH6 mRNA
CTD PMID:11136700 PMID:31009642 NCBI chr15:28,418,120...28,442,316 JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions ISO Valsartan inhibits the reaction [Isoproterenol results in increased expression of MYH7 mRNA] CTD PMID:31009642 NCBI chr15:28,446,550...28,469,888 JBrowse link
G Nfil3 nuclear factor, interleukin 3 regulated multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of NFIL3 mRNA] CTD PMID:19225232 NCBI chr17:12,280,499...12,295,728 JBrowse link
G Nos1 nitric oxide synthase 1 decreases expression EXP Valsartan results in decreased expression of NOS1 protein CTD PMID:31023080 NCBI chr12:38,615,111...38,795,492 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein] CTD PMID:32197949 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP
ISO
[fluvastatin co-treated with Valsartan] results in increased expression of NOS3 mRNA; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of NOS3 protein]]
Valsartan results in decreased expression of NOS3 protein
Valsartan inhibits the reaction [Oxygen deficiency results in increased phosphorylation of NOS3 protein]
CTD PMID:11897773 PMID:18436887 PMID:28951255 PMID:31023080 NCBI chr 4:10,793,834...10,814,170 JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Valsartan inhibits reaction [streptozotocin decreases expression of Nphs1 mRNA and protein in kidney] RGD PMID:17624267 RGD:38596322 NCBI chr 1:85,720,812...85,749,079 JBrowse link
G Nppa natriuretic peptide A multiple interactions
decreases expression
EXP
ISO
[Valsartan co-treated with benazepril] results in decreased expression of NPPA mRNA; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPA protein]
Valsartan results in decreased expression of NPPA mRNA
CTD PMID:11136700 PMID:23288202 PMID:31009642 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Nppb natriuretic peptide B multiple interactions
decreases expression
ISO
EXP
Valsartan inhibits the reaction [CHOP protocol results in increased expression of NPPB protein]
Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of NPPB protein]
Valsartan results in decreased expression of NPPB mRNA
[Valsartan co-treated with benazepril] results in decreased expression of NPPB mRNA
Valsartan results in decreased expression of NPPB protein
CTD PMID:11136700 PMID:12417542 PMID:16247790 PMID:31009642 NCBI chr 5:158,416,813...158,418,175 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of NQO1 protein] CTD PMID:32197949 NCBI chr19:35,295,633...35,310,528 JBrowse link
G Nup98 nucleoporin 98 and 96 precursor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of NUP98 mRNA] CTD PMID:19225232 NCBI chr 1:156,494,423...156,591,415 JBrowse link
G Osr1 odd-skipped related transcription factor 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of OSR1 protein] CTD PMID:20175999 NCBI chr 6:32,369,561...32,380,822 JBrowse link
G Pde3a phosphodiesterase 3A increases expression EXP Valsartan results in increased expression of PDE3A mRNA CTD PMID:19027736 NCBI chr 4:174,172,804...174,443,944 JBrowse link
G Plaur plasminogen activator, urokinase receptor multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of PLAUR mRNA] CTD PMID:19225232 NCBI chr 1:80,053,441...80,068,384 JBrowse link
G Postn periostin multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of POSTN mRNA] CTD PMID:17485602 NCBI chr 2:138,527,714...138,559,098 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO Valsartan results in decreased expression of PPARG mRNA CTD PMID:22768174 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in decreased expression of PPP1R3C mRNA] CTD PMID:19225232 NCBI chr 1:234,460,958...234,465,961 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 mRNA]
Valsartan inhibits the reaction [AGT protein results in increased expression of PTGS2 protein]
CTD PMID:19145780 PMID:19225232 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Ptpn6 protein tyrosine phosphatase, non-receptor type 6 multiple interactions EXP Valsartan promotes the reaction [AGT protein promotes the reaction [PTPN6 protein binds to MTUS1 protein]] CTD PMID:17068200 NCBI chr 4:157,526,034...157,550,783 JBrowse link
G Rcan1 regulator of calcineurin 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of RCAN1 mRNA] CTD PMID:19225232 NCBI chr11:31,622,208...31,702,150 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased phosphorylation of RELA protein] CTD PMID:32197949 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Ren renin multiple interactions
increases expression
increases activity
ISO
EXP
[benazepril co-treated with Valsartan] results in increased activity of REN protein
Valsartan results in increased expression of REN protein
Valsartan results in increased activity of REN protein
CTD PMID:8505092 PMID:10836730 PMID:11501062 NCBI chr13:44,796,260...44,807,491 JBrowse link
G Rgs3 regulator of G-protein signaling 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of RGS3 mRNA] CTD PMID:19225232 NCBI chr 5:76,022,038...76,161,895 JBrowse link
G Sele selectin E multiple interactions ISO Valsartan inhibits the reaction [sodium arsenite results in increased expression of SELE protein] CTD PMID:28973481 NCBI chr13:76,402,841...76,412,741 JBrowse link
G Serpine1 serpin family E member 1 multiple interactions
decreases expression
ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased secretion of SERPINE1 protein]
Valsartan results in decreased expression of SERPINE1 mRNA; Valsartan results in decreased expression of SERPINE1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of SERPINE1 protein; Valsartan inhibits the reaction [AGT protein results in increased activity of SERPINE1 protein]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SERPINE1 protein]
CTD PMID:11244025 PMID:21051829 NCBI chr12:19,601,272...19,611,657 JBrowse link
G Slc12a3 solute carrier family 12 member 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of SLC12A3 protein] CTD PMID:20175999 NCBI chr19:10,630,649...10,679,250 JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO Valsartan inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:205,338,698...205,498,486 JBrowse link
G Slc25a32 solute carrier family 25 member 32 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SLC25A32 mRNA] CTD PMID:19225232 NCBI chr 7:70,142,958...70,160,726 JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]]; naloxonazine inhibits the reaction [Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Valsartan inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:12658023 PMID:17199717 NCBI chr10:54,666,015...54,671,581 JBrowse link
G Smad3 SMAD family member 3 multiple interactions
decreases expression
EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of SMAD3 protein]
Valsartan results in decreased expression of SMAD3 protein
CTD PMID:15619341 PMID:16872305 NCBI chr 8:64,126,829...64,236,960 JBrowse link
G Smad7 SMAD family member 7 multiple interactions
increases expression
EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in decreased expression of SMAD7 protein]
Valsartan results in increased expression of SMAD7 protein
CTD PMID:15619341 PMID:16872305 NCBI chr18:68,988,429...69,016,774 JBrowse link
G Snn stannin multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SNN mRNA] CTD PMID:19225232 NCBI chr10:4,572,933...4,581,606 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [benazepril co-treated with Valsartan] results in increased expression of SOD1 protein CTD PMID:20445533 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of SPP1 protein] CTD PMID:11115077 NCBI chr14:5,308,885...5,315,120 JBrowse link
G Spry2 sprouty RTK signaling antagonist 2 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of SPRY2 mRNA] CTD PMID:19225232 NCBI chr15:82,692,312...82,697,408 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein affects the localization of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT1 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT1 protein] CTD PMID:12846741 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Valsartan inhibits the reaction [AGT protein affects the localization of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased activity of STAT3 protein]; Valsartan inhibits the reaction [AGT protein results in increased phosphorylation of STAT3 protein] CTD PMID:12846741 NCBI chr10:85,811,206...85,863,057 JBrowse link
G Syp synaptophysin multiple interactions ISO
EXP
Valsartan inhibits the reaction [Streptozocin results in decreased expression of SYP protein]
Valsartan inhibits the reaction [AGT protein results in decreased expression of SYP protein]; Valsartan inhibits the reaction [AGT protein results in increased ubiquitination of SYP protein]
CTD PMID:18487452 NCBI chr  X:14,849,444...14,864,553 JBrowse link
G Tek TEK receptor tyrosine kinase multiple interactions EXP Valsartan inhibits the reaction [AGT protein results in increased expression of TEK mRNA] CTD PMID:14638905 NCBI chr 5:109,607,077...109,733,805 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
ISO
EXP
[benazepril co-treated with Valsartan] results in decreased expression of TGFB1 protein
Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]
Valsartan results in decreased expression of TGFB1 protein
[Tacrolimus co-treated with Valsartan] results in increased expression of TGFB1 protein; Valsartan inhibits the reaction [Bleomycin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Ovalbumin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [Tacrolimus results in increased expression of TGFB1 protein]
CTD PMID:11798641 PMID:15619341 PMID:16115399 PMID:16549154 PMID:16872305 PMID:16928621 PMID:17680535 PMID:17703430 PMID:18390891 PMID:19080339 PMID:23733546 PMID:33631230 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions
decreases expression
EXP Valsartan inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR2 mRNA]
Valsartan results in decreased expression of TGFBR2 mRNA
CTD PMID:15619341 PMID:16872305 NCBI chr 8:115,794,537...115,883,615 JBrowse link
G Tgif1 TGFB-induced factor homeobox 1 multiple interactions ISO Valsartan inhibits the reaction [AGT protein results in increased expression of TGIF1 mRNA] CTD PMID:19225232 NCBI chr 9:110,748,094...110,757,714 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
ISO
EXP
Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of TIMP1 protein]
Valsartan results in decreased expression of TIMP1 mRNA; Valsartan results in decreased expression of TIMP1 protein
[Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 mRNA; [Valsartan co-treated with Fosinopril] results in decreased expression of TIMP1 protein; Valsartan inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA]
CTD PMID:12846741 PMID:15504291 PMID:21051829 NCBI chr  X:1,212,969...1,217,714 JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[Metformin co-treated with rosiglitazone co-treated with Valsartan co-treated with Ezetimibe] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with rosiglitazone co-treated with Valsartan] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Valsartan inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]
Valsartan inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]
CTD PMID:16865780 PMID:18436887 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in increased expression of TP53 mRNA] CTD PMID:32197949 NCBI chr10:54,300,070...54,311,525 JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP Valsartan promotes the reaction [AGT protein results in increased expression of TUBB3 protein] CTD PMID:17068200 NCBI chr19:51,457,187...51,466,243 JBrowse link
G Tug1 taurine up-regulated 1 multiple interactions EXP Valsartan inhibits the reaction [Cyclophosphamide results in decreased expression of TUG1 mRNA] CTD PMID:32197949 NCBI chr14:78,519,894...78,526,927 JBrowse link
G Ube2v2 ubiquitin conjugating enzyme E2 V2 multiple interactions ISO
EXP
Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 mRNA]; Valsartan promotes the reaction [AGT protein results in increased expression of UBE2V2 protein]; Valsartan promotes the reaction [Oxygen deficiency results in increased expression of UBE2V2 mRNA] CTD PMID:16769992 PMID:17068200 NCBI chr11:85,304,528...85,338,430 JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
ISO
EXP
Valsartan results in decreased expression of VEGFA mRNA
Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [AGT protein results in increased expression of VEGFA protein]; Valsartan inhibits the reaction [Oxygen deficiency promotes the reaction [AGT protein results in increased expression of VEGFA protein]]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
CTD PMID:11897773 PMID:14638905 PMID:14718351 PMID:17724226 PMID:22768174 NCBI chr 9:14,955,300...14,970,641 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        pharmacological role 18815
          antagonist 16263
            hormone antagonist 11569
              angiotensin receptor antagonist 356
                Byvalson 0
                PD123319 30
                azilsartan + 3
                azilsartan kamedoxomil 0
                azilsartan medoxomil 0
                candesartan 71
                eprosartan + 5
                forasartan 0
                irbesartan 44
                losartan + 168
                olmesartan 28
                telmisartan 97
                valsartan + 146
                zolasartan 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      application 19396
        pharmaceutical 19294
          drug 19294
            receptor modulator 18848
              hormone receptor modulator 18837
                hormone antagonist 11569
                  angiotensin receptor antagonist 356
                    Byvalson 0
                    PD123319 30
                    azilsartan + 3
                    azilsartan kamedoxomil 0
                    azilsartan medoxomil 0
                    candesartan 71
                    eprosartan + 5
                    forasartan 0
                    irbesartan 44
                    losartan + 168
                    olmesartan 28
                    telmisartan 97
                    valsartan + 146
                    zolasartan 0
paths to the root