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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:beta-glucoside
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Accession:CHEBI:60980 term browser browse the term
Definition:A glucoside in which the anomeric carbon of the glycosidic bond is in a beta configuration
Synonyms:related_synonym: beta-glucosides



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(+)-syringaresinol beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions EXP acanthoside B inhibits the reaction [Scopolamine results in increased expression of ACHE protein] CTD PMID:31077737 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP [acanthoside B co-treated with Scopolamine] results in increased expression of BDNF protein CTD PMID:31077737 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Cat catalase multiple interactions EXP acanthoside B inhibits the reaction [Scopolamine results in decreased activity of CAT protein] CTD PMID:31077737 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP acanthoside B inhibits the reaction [Scopolamine results in decreased phosphorylation of CREB1 protein] CTD PMID:31077737 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Il10 interleukin 10 multiple interactions EXP acanthoside B inhibits the reaction [Scopolamine results in decreased expression of IL10 protein] CTD PMID:31077737 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL1B protein] CTD PMID:31077737 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il6 interleukin 6 multiple interactions EXP acanthoside B inhibits the reaction [Scopolamine results in increased expression of IL6 protein] CTD PMID:31077737 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP acanthoside B inhibits the reaction [Scopolamine results in increased expression of NOS2 protein] CTD PMID:31077737 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions EXP [acanthoside B co-treated with Scopolamine] results in increased phosphorylation of NTRK2 protein CTD PMID:31077737 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP acanthoside B inhibits the reaction [Scopolamine results in increased expression of PTGS2 protein] CTD PMID:31077737 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP acanthoside B inhibits the reaction [Scopolamine results in increased expression of TNF protein] CTD PMID:31077737 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
(20S)-ginsenoside Rh1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos FBJ osteosarcoma oncogene increases expression ISO ginsenoside Rh1 results in increased expression of FOS mRNA CTD PMID:16204943 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:21875580 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA] CTD PMID:16557482 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 decreases expression EXP ginsenoside Rh1 results in decreased expression of IL4 CTD PMID:22855946 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Itga4 integrin alpha 4 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 2:79,255,426...79,333,114
Ensembl chr 2:79,255,426...79,333,123
JBrowse link
G Itgal integrin alpha L multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr 7:127,296,139...127,335,137
Ensembl chr 7:127,296,260...127,335,138
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]] CTD PMID:21875580 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Itgb2 integrin beta 2 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]] CTD PMID:21875580 NCBI chr10:77,530,329...77,565,708
Ensembl chr10:77,530,252...77,565,708
JBrowse link
G Jun jun proto-oncogene decreases activity EXP ginsenoside Rh1 results in decreased activity of JUN protein CTD PMID:22855946 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Lpl lipoprotein lipase increases secretion EXP ginsenoside Rh1 results in increased secretion of LPL protein CTD PMID:8988629 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Pgr progesterone receptor increases expression ISO ginsenoside Rh1 results in increased expression of PGR protein CTD PMID:16204943 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG mRNA]; ginsenoside Rh1 inhibits the reaction [bisphenol A results in increased expression of PPARG protein] CTD PMID:32623698 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA] CTD PMID:16557482 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Sele selectin, endothelial cell multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:21875580 NCBI chr 1:164,039,614...164,058,487
Ensembl chr 1:164,048,234...164,057,677
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO ginsenoside Rh1 results in increased expression of TFF1 mRNA CTD PMID:16204943 NCBI chr17:31,161,395...31,165,060
Ensembl chr17:31,161,395...31,165,277
JBrowse link
G Tnf tumor necrosis factor decreases response to substance
multiple interactions
decreases expression
ISO
EXP
ginsenoside Rh1 results in decreased susceptibility to TNF protein
ginsenoside Rh1 inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Rh1 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]
ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGA4 protein binds to ITGB1 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of [ITGAL protein binds to ITGB2 protein]]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of SELE protein]; ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
ginsenoside Rh1 results in decreased expression of TNF
CTD PMID:16557482 PMID:21875580 PMID:22855946 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO ginsenoside Rh1 inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:21875580 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
(20S)-ginsenoside Rh2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein increases expression ISO ginsenoside Rh2 results in increased expression of BAX protein CTD PMID:26482938 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression ISO ginsenoside Rh2 results in decreased expression of BCL2 protein CTD PMID:26482938 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Casp3 caspase 3 increases cleavage ISO ginsenoside Rh2 results in increased cleavage of CASP3 protein CTD PMID:26482938 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO ginsenoside Rh2 results in decreased expression of CCND1 protein CTD PMID:26482938 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC1 protein CTD PMID:26482938 NCBI chr 4:129,516,104...129,542,646
Ensembl chr 4:129,516,104...129,542,713
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC2 protein CTD PMID:26482938 NCBI chr10:36,974,297...37,001,889
Ensembl chr10:36,974,544...37,001,889
JBrowse link
G Hdac6 histone deacetylase 6 decreases expression ISO ginsenoside Rh2 results in decreased expression of HDAC6 protein CTD PMID:26482938 NCBI chr  X:7,930,116...7,948,047
Ensembl chr  X:7,930,120...7,947,889
JBrowse link
G Il6 interleukin 6 multiple interactions ISO ginsenoside Rh2 inhibits the reaction [Galactose results in increased secretion of IL6 protein] CTD PMID:29412148 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK1 protein CTD PMID:26482938 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases phosphorylation ISO ginsenoside Rh2 results in decreased phosphorylation of MAPK3 protein CTD PMID:26482938 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
(R)-amygdalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO [peoniflorin co-treated with benzoylpaeoniflorin co-treated with Amygdalin] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 mRNA]; Amygdalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 mRNA] CTD PMID:33149750 NCBI chr 2:36,216,742...36,258,593
Ensembl chr 2:36,230,426...36,252,272
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [peoniflorin co-treated with benzoylpaeoniflorin co-treated with Amygdalin] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Amygdalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:33149750 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ACACA mRNA] CTD PMID:30721698 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 multiple interactions ISO
EXP
beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]
beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of CCL2 protein]
CTD PMID:16253226 PMID:30721698 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of CEBPA mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of CEBPA protein] CTD PMID:30721698 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of FAS mRNA] CTD PMID:30721698 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] CTD PMID:16253226 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Il6 interleukin 6 multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of IL6 protein] CTD PMID:30721698 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ins2 insulin II multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ACACA mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of CEBPA mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of CEBPA protein]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of FAS mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG protein]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SCD1 mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SCD1 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK8 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK9 protein] CTD PMID:30721698 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK1 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:30721698 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK3 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:30721698 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK8 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein] CTD PMID:30721698 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of MAPK9 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein] CTD PMID:30721698 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of PPARG protein] CTD PMID:30721698 NCBI chr 6:115,360,879...115,490,404
Ensembl chr 6:115,360,951...115,490,399
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased localization of RELA protein] CTD PMID:16253226 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Scd1 stearoyl-Coenzyme A desaturase 1 multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SCD1 mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SCD1 protein] CTD PMID:30721698 NCBI chr19:44,394,450...44,407,709
Ensembl chr19:44,394,455...44,407,879
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions EXP beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 protein] CTD PMID:30721698 NCBI chr11:60,199,084...60,224,186
Ensembl chr11:60,199,089...60,222,581
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of CCL2 mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased localization of RELA protein]
beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of IL6 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased phosphorylation of MAPK9 protein]
CTD PMID:16253226 PMID:30721698 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO beta-penta-O-galloyl-glucose inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:16253226 NCBI chr 3:116,110,020...116,129,688
Ensembl chr 3:116,109,949...116,129,688
JBrowse link
4-methylumbelliferyl beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gaa glucosidase, alpha, acid multiple interactions
increases metabolic processing
ISO GAA gene SNP inhibits the reaction [GAA protein results in increased metabolism of 4-methylumbelliferyl glucoside] CTD PMID:21963784 NCBI chr11:119,267,963...119,285,458
Ensembl chr11:119,267,887...119,285,454
JBrowse link
albiflorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Drd2 dopamine receptor D2 affects expression ISO albiflorin affects the expression of DRD2 CTD PMID:26475043 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A affects expression ISO albiflorin affects the expression of HTR1A CTD PMID:26475043 NCBI chr13:105,443,693...105,448,133
Ensembl chr13:105,443,639...105,448,122
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A affects expression ISO albiflorin affects the expression of HTR2A CTD PMID:26475043 NCBI chr14:74,640,874...74,706,859
Ensembl chr14:74,640,840...74,709,494
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 affects expression ISO albiflorin affects the expression of SLC6A3 CTD PMID:26475043 NCBI chr13:73,536,128...73,578,672
Ensembl chr13:73,536,747...73,578,672
JBrowse link
G Th tyrosine hydroxylase affects expression ISO albiflorin affects the expression of TH CTD PMID:26475043 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
apigenin 7-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gypa glycophorin A increases expression ISO apigetrin results in increased expression of GYPA protein CTD PMID:25058688 NCBI chr 8:80,494,045...80,510,785
Ensembl chr 8:80,493,781...80,510,542
JBrowse link
asperuloside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 multiple interactions EXP [lipopolysaccharide, E coli O55-B5 co-treated with asperuloside] results in increased expression of HMOX1 protein; asperuloside inhibits the reaction [Dextran Sulfate results in decreased expression of HMOX1 protein] CTD PMID:33974900 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Il10 interleukin 10 multiple interactions EXP asperuloside inhibits the reaction [Dextran Sulfate results in decreased expression of IL10 protein] CTD PMID:33974900 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il6 interleukin 6 multiple interactions EXP asperuloside inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; asperuloside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; asperuloside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein] CTD PMID:33974900 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP asperuloside inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:33974900 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization
multiple interactions
EXP asperuloside affects the localization of NFE2L2 protein
[asperuloside co-treated with Dextran Sulfate] results in increased expression of NFE2L2 protein; [lipopolysaccharide, E coli O55-B5 co-treated with asperuloside] results in increased expression of NFE2L2 protein; asperuloside affects the reaction [NFE2L2 protein affects the expression of NQO1 mRNA]; asperuloside inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of NFE2L2 protein]
CTD PMID:33974900 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 multiple interactions EXP asperuloside affects the reaction [NFE2L2 protein affects the expression of NQO1 mRNA] CTD PMID:33974900 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP asperuloside inhibits the reaction [Dextran Sulfate results in increased phosphorylation of RELA protein] CTD PMID:33974900 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP asperuloside inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; asperuloside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; asperuloside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; asperuloside inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16508180 PMID:33974900 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
calycosin-7-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Epo erythropoietin increases expression ISO calycosin-7-O-beta-D-glucoside results in increased expression of EPO mRNA CTD PMID:21309574 NCBI chr 5:137,483,020...137,485,816
Ensembl chr 5:137,483,020...137,533,242
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions
increases expression
ISO calycosin-7-O-beta-D-glucoside results in increased expression of and results in decreased degradation of HIF1A protein
calycosin-7-O-beta-D-glucoside results in increased expression of HIF1A mRNA
CTD PMID:21309574 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
daidzein 7-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases expression
multiple interactions
ISO daidzin results in increased expression of ACHE mRNA
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [daidzin results in increased expression of ACHE mRNA]; 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [daidzin results in increased expression of and results in increased activity of ACHE protein]; daidzin results in increased expression of and results in increased activity of ACHE protein
CTD PMID:31034797 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of ACSL3 mRNA CTD PMID:27424125 NCBI chr 1:78,657,825...78,707,743
Ensembl chr 1:78,657,825...78,707,743
JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ALDH1A2 mRNA CTD PMID:27424125 NCBI chr 9:71,215,789...71,296,243
Ensembl chr 9:71,215,789...71,296,243
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions ISO daidzin inhibits the reaction [ALDH2 protein results in increased hydrolysis of 4-nitrophenyl acetate]; daidzin inhibits the reaction [ALDH2 protein results in increased oxidation of propionaldehyde] CTD PMID:21349255 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824
JBrowse link
G Anpep alanyl (membrane) aminopeptidase multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ANPEP mRNA CTD PMID:27424125 NCBI chr 7:79,821,803...79,848,210
Ensembl chr 7:79,821,803...79,861,059
JBrowse link
G Atoh8 atonal bHLH transcription factor 8 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of ATOH8 mRNA CTD PMID:27424125 NCBI chr 6:72,206,174...72,235,780
Ensembl chr 6:72,206,177...72,235,577
JBrowse link
G Bckdk branched chain ketoacid dehydrogenase kinase multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of BCKDK mRNA CTD PMID:27424125 NCBI chr 7:127,904,073...127,909,664
Ensembl chr 7:127,904,082...127,910,221
JBrowse link
G Bdnf brain derived neurotrophic factor multiple interactions EXP daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of BDNF protein] CTD PMID:32450180 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Bpgm 2,3-bisphosphoglycerate mutase multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of BPGM mRNA CTD PMID:27424125 NCBI chr 6:34,476,356...34,505,136
Ensembl chr 6:34,476,207...34,505,613
JBrowse link
G Cabp5 calcium binding protein 5 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CABP5 mRNA CTD PMID:27424125 NCBI chr 7:13,385,960...13,408,887
Ensembl chr 7:13,398,132...13,408,887
JBrowse link
G Cacybp calcyclin binding protein multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CACYBP mRNA CTD PMID:27424125 NCBI chr 1:160,202,367...160,212,892
Ensembl chr 1:160,202,367...160,212,875
JBrowse link
G Casp8ap2 caspase 8 associated protein 2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CASP8AP2 mRNA CTD PMID:27424125 NCBI chr 4:32,615,470...32,653,271
Ensembl chr 4:32,615,451...32,653,265
JBrowse link
G Cat catalase multiple interactions EXP daidzin inhibits the reaction [Pentylenetetrazole results in decreased activity of CAT protein] CTD PMID:32450180 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cd200r1 CD200 receptor 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CD200R1 mRNA CTD PMID:27424125 NCBI chr16:44,765,736...44,794,977
Ensembl chr16:44,765,736...44,794,978
JBrowse link
G Cybrd1 cytochrome b reductase 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of CYBRD1 mRNA CTD PMID:27424125 NCBI chr 2:71,118,054...71,142,926
Ensembl chr 2:71,117,923...71,142,926
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of CYP11A1 mRNA CTD PMID:28964809 NCBI chr 9:57,998,024...58,027,031
Ensembl chr 9:58,006,411...58,027,023
JBrowse link
G Dennd2d DENN/MADD domain containing 2D multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of DENND2D mRNA CTD PMID:27424125 NCBI chr 3:106,482,431...106,503,030
Ensembl chr 3:106,482,405...106,503,030
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT1 mRNA CTD PMID:28964809 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3a DNA methyltransferase 3A multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of DNMT3A mRNA CTD PMID:28964809 NCBI chr12:3,801,559...3,914,443
Ensembl chr12:3,806,007...3,914,443
JBrowse link
G Dpp9 dipeptidylpeptidase 9 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of DPP9 mRNA CTD PMID:27424125 NCBI chr17:56,186,674...56,218,889
Ensembl chr17:56,186,807...56,218,905
JBrowse link
G Edrf1 erythroid differentiation regulatory factor 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of EDRF1 mRNA CTD PMID:27424125 NCBI chr 7:133,637,544...133,673,017
Ensembl chr 7:133,637,543...133,672,971
JBrowse link
G Efhd1 EF hand domain containing 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of EFHD1 mRNA CTD PMID:27424125 NCBI chr 1:87,264,353...87,310,841
Ensembl chr 1:87,264,363...87,310,839
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased expression of ESR2 mRNA CTD PMID:28964809 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Fam171a2 family with sequence similarity 171, member A2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FAM171A2 mRNA CTD PMID:27424125 NCBI chr11:102,436,981...102,447,677
Ensembl chr11:102,436,981...102,447,682
JBrowse link
G Fam180a family with sequence similarity 180, member A multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM180A mRNA CTD PMID:27424125 NCBI chr 6:35,312,743...35,326,141
Ensembl chr 6:35,312,668...35,326,141
JBrowse link
G Fam210b family with sequence similarity 210, member B multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FAM210B mRNA CTD PMID:27424125 NCBI chr 2:172,345,570...172,355,749
Ensembl chr 2:172,345,565...172,355,749
JBrowse link
G Fam241b family with sequence similarity 241, member B multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of FAM241B mRNA CTD PMID:27424125 NCBI chr10:62,107,656...62,111,050
Ensembl chr10:62,107,655...62,143,920
JBrowse link
G Fgd6 FYVE, RhoGEF and PH domain containing 6 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of FGD6 mRNA CTD PMID:27424125 NCBI chr10:94,035,979...94,145,339
Ensembl chr10:94,036,001...94,145,339
JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of FHL2 mRNA CTD PMID:27424125 NCBI chr 1:43,123,071...43,198,343
Ensembl chr 1:43,123,074...43,196,984
JBrowse link
G Fos FBJ osteosarcoma oncogene increases expression ISO daidzin results in increased expression of FOS mRNA CTD PMID:17142977 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Galnt15 polypeptide N-acetylgalactosaminyltransferase 15 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of GALNT15 mRNA CTD PMID:27424125 NCBI chr14:32,028,782...32,062,204
Ensembl chr14:32,028,989...32,062,197
JBrowse link
G Gng5 guanine nucleotide binding protein (G protein), gamma 5 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of GNG5 mRNA CTD PMID:27424125 NCBI chr 3:146,499,836...146,505,543
Ensembl chr 3:146,499,807...146,505,572
JBrowse link
G Hipk4 homeodomain interacting protein kinase 4 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of HIPK4 mRNA CTD PMID:27424125 NCBI chr 7:27,523,261...27,531,180
Ensembl chr 7:27,523,267...27,531,175
JBrowse link
G Hmcn1 hemicentin 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of HMCN1 mRNA CTD PMID:27424125 NCBI chr 1:150,562,500...150,993,652
Ensembl chr 1:150,562,524...150,993,435
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP daidzin inhibits the reaction [Pentylenetetrazole results in decreased expression of HMOX1 protein] CTD PMID:32450180 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of HSD3B1 mRNA CTD PMID:28964809 NCBI chr 3:98,842,356...98,859,794
Ensembl chr 3:98,852,194...98,859,794
JBrowse link
G Il6ra interleukin 6 receptor, alpha multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of IL6R mRNA CTD PMID:27424125 NCBI chr 3:89,869,324...89,913,196
Ensembl chr 3:89,864,059...89,913,196
JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of ISG20L2 mRNA CTD PMID:27424125 NCBI chr 3:87,930,314...87,940,686
Ensembl chr 3:87,930,314...87,940,686
JBrowse link
G Kdm5a lysine (K)-specific demethylase 5A multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of KDM5A mRNA CTD PMID:27424125 NCBI chr 6:120,364,099...120,444,574
Ensembl chr 6:120,364,124...120,444,574
JBrowse link
G Kitl kit ligand multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KITLG mRNA CTD PMID:27424125 NCBI chr10:100,015,615...100,100,416
Ensembl chr10:100,015,630...100,100,416
JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of KNSTRN mRNA CTD PMID:27424125 NCBI chr 2:118,813,988...118,837,210
Ensembl chr 2:118,814,003...118,853,957
JBrowse link
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LDLRAP1 mRNA CTD PMID:27424125 NCBI chr 4:134,741,554...134,768,032
Ensembl chr 4:134,741,554...134,768,024
JBrowse link
G Lmod1 leiomodin 1 (smooth muscle) multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LMOD1 mRNA CTD PMID:27424125 NCBI chr 1:135,324,813...135,368,065
Ensembl chr 1:135,324,807...135,368,065
JBrowse link
G Lrg1 leucine-rich alpha-2-glycoprotein 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of LRG1 mRNA CTD PMID:27424125 NCBI chr17:56,119,678...56,121,946
Ensembl chr17:56,119,678...56,122,001
JBrowse link
G Lsr lipolysis stimulated lipoprotein receptor multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA CTD PMID:27424125 NCBI chr 7:30,957,770...30,973,469
Ensembl chr 7:30,957,770...30,973,464
JBrowse link
G Mrpl33 mitochondrial ribosomal protein L33 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of MRPL33 mRNA CTD PMID:27424125 NCBI chr 5:31,613,951...31,622,644
Ensembl chr 5:31,596,935...31,664,384
JBrowse link
G Mtmr11 myotubularin related protein 11 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of MTMR11 mRNA CTD PMID:27424125 NCBI chr 3:96,161,949...96,171,718
Ensembl chr 3:96,162,004...96,171,718
JBrowse link
G Myof myoferlin multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of MYOF mRNA CTD PMID:27424125 NCBI chr19:37,899,036...38,043,577
Ensembl chr19:37,899,036...38,043,577
JBrowse link
G Nefh neurofilament, heavy polypeptide increases expression ISO daidzin results in increased expression of NEFH mRNA; daidzin results in increased expression of NEFH protein CTD PMID:31034797 NCBI chr11:4,938,754...4,948,064
Ensembl chr11:4,938,754...4,948,064
JBrowse link
G Nefl neurofilament, light polypeptide increases expression ISO daidzin results in increased expression of NEFL mRNA; daidzin results in increased expression of NEFL protein CTD PMID:31034797 NCBI chr14:68,083,863...68,089,095
Ensembl chr14:68,083,863...68,089,095
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of NR4A1 mRNA CTD PMID:27424125 NCBI chr15:101,253,902...101,274,795
Ensembl chr15:101,254,269...101,274,795
JBrowse link
G Nr5a1 nuclear receptor subfamily 5, group A, member 1 multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 protein; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in increased methylation of NR5A1 promoter; decitabine inhibits the reaction [[Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of NR5A1 mRNA] CTD PMID:28964809 NCBI chr 2:38,692,656...38,714,542
Ensembl chr 2:38,692,656...38,714,542
JBrowse link
G Pgr progesterone receptor increases expression ISO daidzin results in increased expression of PGR protein CTD PMID:17142977 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611
JBrowse link
G Prima1 proline rich membrane anchor 1 multiple interactions
increases expression
ISO 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [daidzin results in increased expression of PRIMA1 mRNA] CTD PMID:31034797 NCBI chr12:103,194,453...103,242,719
Ensembl chr12:103,196,908...103,242,150
JBrowse link
G Prkaca protein kinase, cAMP dependent, catalytic, alpha multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of PRKACA mRNA CTD PMID:27424125 NCBI chr 8:83,972,978...83,996,444
Ensembl chr 8:83,972,993...83,996,443
JBrowse link
G Prpf40a pre-mRNA processing factor 40A multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PRPF40A mRNA CTD PMID:27424125 NCBI chr 2:53,134,702...53,191,438
Ensembl chr 2:53,134,704...53,191,702
Ensembl chr 2:53,134,704...53,191,702
JBrowse link
G Pspc1 paraspeckle protein 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of PSPC1 mRNA CTD PMID:27424125 NCBI chr14:56,722,441...56,778,318
Ensembl chr14:56,720,710...56,778,316
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of PTH1R mRNA CTD PMID:27424125 NCBI chr 9:110,722,085...110,747,145
Ensembl chr 9:110,722,085...110,747,145
JBrowse link
G Rassf5 Ras association (RalGDS/AF-6) domain family member 5 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of RASSF5 mRNA CTD PMID:27424125 NCBI chr 1:131,176,410...131,245,178
Ensembl chr 1:131,176,410...131,245,258
JBrowse link
G Rgs22 regulator of G-protein signalling 22 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of RGS22 mRNA CTD PMID:27424125 NCBI chr15:35,960,508...36,140,572
Ensembl chr15:36,009,479...36,140,400
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of S1PR3 mRNA CTD PMID:27424125 NCBI chr13:51,408,618...51,422,797
Ensembl chr13:51,408,639...51,422,797
JBrowse link
G Selplg selectin, platelet (p-selectin) ligand multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SELPLG mRNA CTD PMID:27424125 NCBI chr 5:113,817,798...113,832,528
Ensembl chr 5:113,818,536...113,832,644
JBrowse link
G Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SLC16A1 mRNA CTD PMID:27424125 NCBI chr 3:104,638,664...104,658,462
Ensembl chr 3:104,638,668...104,658,462
JBrowse link
G Snx30 sorting nexin family member 30 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of SNX30 mRNA CTD PMID:27424125 NCBI chr 4:59,805,131...59,904,740
Ensembl chr 4:59,805,840...59,904,737
JBrowse link
G Ssc5d scavenger receptor cysteine rich family, 5 domains multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of SSC5D mRNA CTD PMID:27424125 NCBI chr 7:4,925,129...4,944,828
Ensembl chr 7:4,925,785...4,944,826
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR mRNA; [Genistein co-treated with daidzein co-treated with glycitin co-treated with genistin co-treated with daidzin co-treated with glycitein] results in decreased expression of STAR protein CTD PMID:28964809 NCBI chr 8:25,808,474...25,815,982
Ensembl chr 8:25,806,555...25,815,982
JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of STYXL1 mRNA CTD PMID:27424125 NCBI chr 5:135,747,220...135,778,424
Ensembl chr 5:135,747,220...135,778,385
JBrowse link
G Sumo1 small ubiquitin-like modifier 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of SUMO1 mRNA CTD PMID:27424125 NCBI chr 1:59,639,434...59,670,834
Ensembl chr 1:59,586,558...59,670,834
JBrowse link
G Tc2n tandem C2 domains, nuclear multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of TC2N mRNA CTD PMID:27424125 NCBI chr12:101,645,446...101,718,919
Ensembl chr12:101,645,443...101,718,523
JBrowse link
G Trp53i11 transformation related protein 53 inducible protein 11 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in decreased expression of TP53I11 mRNA CTD PMID:27424125 NCBI chr 2:93,187,349...93,201,757
Ensembl chr 2:93,187,548...93,201,759
JBrowse link
G Vcpip1 valosin containing protein (p97)/p47 complex interacting protein 1 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] results in increased expression of VCPIP1 mRNA CTD PMID:27424125 NCBI chr 1:9,718,622...9,748,382
Ensembl chr 1:9,718,622...9,748,382
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP daidzin inhibits the reaction [Pentylenetetrazole results in increased expression of VEGFA protein] CTD PMID:32450180 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link
G Wdr66 WD repeat domain 66 multiple interactions ISO [daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of CFAP251 mRNA CTD PMID:27424125 NCBI chr 5:123,251,725...123,327,484
Ensembl chr 5:123,252,102...123,327,484
JBrowse link
etoposide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 0610040J01Rik RIKEN cDNA 0610040J01 gene affects response to substance ISO C4ORF19 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:63,811,657...63,899,626
Ensembl chr 5:63,812,363...63,899,625
JBrowse link
G 6030458C11Rik RIKEN cDNA 6030458C11 gene affects response to substance ISO C5ORF22 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:12,808,177...12,824,679
Ensembl chr15:12,808,177...12,824,649
JBrowse link
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A affects response to substance
multiple interactions
increases expression
ISO ABCB1 exon polymorphism affects the susceptibility to Etoposide
[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [Celecoxib results in decreased expression of ABCB1] which results in increased susceptibility to Etoposide
Etoposide results in increased expression of ABCB1 mRNA; Etoposide results in increased expression of ABCB1 protein
CTD PMID:12969965 PMID:15239124 PMID:19047049 PMID:19562670 PMID:27570640 More... NCBI chr 5:8,567,091...8,748,575
Ensembl chr 5:8,660,077...8,748,575
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 affects response to substance
multiple interactions
increases expression
decreases uptake
decreases response to substance
ISO
EXP
ABCC1 protein affects the susceptibility to Etoposide
Glucose inhibits the reaction [Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]]; Sodium Azide inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Verapamil inhibits the reaction [ABCC1 protein results in decreased uptake of Etoposide]
Etoposide results in increased expression of ABCC1 mRNA
ABCC1 protein results in decreased susceptibility to Etoposide; ABCC1 results in decreased susceptibility to Etoposide
[GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Etoposide; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Silymarin inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Tocopherols inhibits the reaction [ABCC1 protein affects the export of Etoposide]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]
CTD PMID:7954421 PMID:8968083 PMID:9334814 PMID:10348353 PMID:10856430 More... NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 affects transport
multiple interactions
ISO ABCC2 protein affects the transport of Etoposide
Probenecid promotes the reaction [ABCC2 protein affects the transport of Etoposide]
CTD PMID:15751272 PMID:15849751 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 decreases response to substance ISO ABCC3 protein results in decreased susceptibility to Etoposide CTD PMID:15884115 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions ISO [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Etoposide; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide] CTD PMID:21712253 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Abhd4 abhydrolase domain containing 4 increases expression EXP Etoposide results in increased expression of ABHD4 mRNA CTD PMID:25270620 NCBI chr14:54,254,129...54,269,169
Ensembl chr14:54,254,188...54,270,637
JBrowse link
G Abra actin-binding Rho activating protein increases expression ISO Etoposide results in increased expression of ABRA mRNA CTD PMID:29397400 NCBI chr15:41,865,293...41,869,720
Ensembl chr15:41,864,076...41,869,720
JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain affects response to substance ISO ACADM protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 increases expression
decreases expression
ISO Etoposide results in increased expression of ACE2 mRNA
Etoposide results in decreased expression of ACE2 mRNA
CTD PMID:29397400 PMID:32808185 NCBI chr  X:164,139,342...164,188,418
Ensembl chr  X:164,139,332...164,188,420
JBrowse link
G Aco1 aconitase 1 increases expression EXP Etoposide results in increased expression of ACO1 mRNA CTD PMID:25270620 NCBI chr 4:40,143,265...40,199,009
Ensembl chr 4:40,143,081...40,198,338
JBrowse link
G Acsl3 acyl-CoA synthetase long-chain family member 3 affects response to substance ISO ACSL3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:78,657,825...78,707,743
Ensembl chr 1:78,657,825...78,707,743
JBrowse link
G Acta1 actin alpha 1, skeletal muscle decreases expression ISO Etoposide results in decreased expression of ACTA1 mRNA CTD PMID:29397400 NCBI chr 8:123,891,758...123,894,775
Ensembl chr 8:123,891,769...123,894,751
JBrowse link
G Agrn agrin increases expression ISO Etoposide results in increased expression of AGRN mRNA CTD PMID:17374387 NCBI chr 4:156,165,290...156,197,533
Ensembl chr 4:156,165,290...156,197,488
JBrowse link
G Ahcyl1 S-adenosylhomocysteine hydrolase-like 1 affects response to substance ISO AHCYL1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:107,663,120...107,696,560
Ensembl chr 3:107,663,118...107,696,560
JBrowse link
G Ahi1 Abelson helper integration site 1 increases expression ISO Etoposide results in increased expression of AHI1 protein alternative form CTD PMID:19379585 NCBI chr10:20,952,232...21,080,429
Ensembl chr10:20,952,547...21,080,429
JBrowse link
G Akap12 A kinase (PRKA) anchor protein (gravin) 12 affects response to substance ISO AKAP12 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:4,266,329...4,359,471
Ensembl chr10:4,266,380...4,359,470
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 increases response to substance
increases phosphorylation
multiple interactions
ISO AKT1 protein modified form results in increased susceptibility to Etoposide
Etoposide results in increased phosphorylation of AKT1 protein
Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein; pepstatin inhibits the reaction [AKT1 protein modified form results in increased susceptibility to Etoposide]; PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein]
CTD PMID:17699715 PMID:17935137 PMID:27769712 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions ISO [Cyclophosphamide co-treated with Carmustine co-treated with Etoposide] results in decreased activity of ALAD protein CTD PMID:19162187 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Alas1 aminolevulinic acid synthase 1 increases expression EXP Etoposide results in increased expression of ALAS1 mRNA CTD PMID:25270620 NCBI chr 9:106,233,455...106,247,954
Ensembl chr 9:106,233,455...106,248,654
JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 affects response to substance ISO ALDH3A1 protein affects the susceptibility to Etoposide CTD PMID:15905174 NCBI chr11:61,208,510...61,218,418
Ensembl chr11:61,207,537...61,218,421
JBrowse link
G Aldoc aldolase C, fructose-bisphosphate affects response to substance
multiple interactions
ISO
EXP
ALDOC protein affects the susceptibility to Etoposide
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ALDOC protein
CTD PMID:16217747 PMID:29733421 NCBI chr11:78,323,073...78,327,781
Ensembl chr11:78,322,968...78,327,781
JBrowse link
G Alppl2 alkaline phosphatase, placental-like 2 affects response to substance ISO ALPG protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:87,086,690...87,095,934
Ensembl chr 1:87,086,694...87,089,928
JBrowse link
G Ank1 ankyrin 1, erythroid increases expression ISO Etoposide results in increased expression of ANK1 mRNA CTD PMID:29397400 NCBI chr 8:22,974,836...23,150,501
Ensembl chr 8:22,974,844...23,150,497
JBrowse link
G Ankrd10 ankyrin repeat domain 10 decreases expression ISO Etoposide results in decreased expression of ANKRD10 mRNA CTD PMID:21527772 NCBI chr 8:11,611,581...11,635,926
Ensembl chr 8:11,611,583...11,635,757
JBrowse link
G Ankrd27 ankyrin repeat domain 27 (VPS9 domain) decreases expression EXP Etoposide results in decreased expression of ANKRD27 mRNA CTD PMID:25270620 NCBI chr 7:35,586,226...35,639,237
Ensembl chr 7:35,586,244...35,639,226
JBrowse link
G Ankrd28 ankyrin repeat domain 28 affects response to substance ISO ANKRD28 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:31,698,768...31,830,567
Ensembl chr14:31,698,768...31,830,651
JBrowse link
G Anxa4 annexin A4 increases expression ISO Etoposide results in increased expression of ANXA4 mRNA CTD PMID:17374387 NCBI chr 6:86,736,840...86,793,634
Ensembl chr 6:86,736,840...86,793,584
JBrowse link
G Anxa7 annexin A7 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ANXA7 protein CTD PMID:29733421 NCBI chr14:20,455,261...20,480,133
Ensembl chr14:20,455,260...20,480,133
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression EXP Etoposide results in increased expression of APAF1 mRNA CTD PMID:25270620 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 decreases response to substance ISO APEX1 protein results in decreased susceptibility to Etoposide CTD PMID:20856196 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139
JBrowse link
G Aplp1 amyloid beta (A4) precursor-like protein 1 decreases expression EXP Etoposide results in decreased expression of APLP1 mRNA CTD PMID:25270620 NCBI chr 7:30,434,980...30,445,582
Ensembl chr 7:30,434,982...30,445,535
JBrowse link
G Apol8 apolipoprotein L 8 increases expression EXP Etoposide results in increased expression of APOL8 mRNA CTD PMID:25270620 NCBI chr15:77,745,109...77,757,062
Ensembl chr15:77,747,798...77,757,003
JBrowse link
G Aqp1 aquaporin 1 decreases expression EXP Etoposide results in decreased expression of AQP1 mRNA CTD PMID:25270620 NCBI chr 6:55,336,299...55,348,555
Ensembl chr 6:55,336,432...55,348,555
JBrowse link
G Ar androgen receptor multiple interactions
increases degradation
ISO calpain inhibitor 2 inhibits the reaction [Etoposide results in increased degradation of AR protein]; CAST inhibits the reaction [Etoposide results in increased degradation of AR protein]; Etoposide inhibits the reaction [Androgens results in increased activity of AR protein]; Etoposide inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:18726991 PMID:28377212 PMID:30818834 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215
JBrowse link
G Areg amphiregulin increases expression
decreases expression
ISO
EXP
Etoposide results in increased expression of AREG mRNA; Etoposide results in increased expression of AREG protein
Etoposide results in decreased expression of AREG mRNA
CTD PMID:15228094 PMID:25270620 NCBI chr 5:91,139,599...91,148,432
Ensembl chr 5:91,139,599...91,148,432
JBrowse link
G Arg2 arginase type II decreases expression ISO Etoposide results in decreased expression of ARG2 mRNA CTD PMID:29397400 NCBI chr12:79,130,788...79,156,301
Ensembl chr12:79,130,777...79,156,301
JBrowse link
G Arhgdib Rho, GDP dissociation inhibitor (GDI) beta increases expression ISO Etoposide results in increased expression of ARHGDIB mRNA CTD PMID:21527772 NCBI chr 6:136,923,655...136,941,899
Ensembl chr 6:136,923,655...136,941,899
JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 increases response to substance EXP ARIH1 mutant form results in increased susceptibility to Etoposide CTD PMID:25624349 NCBI chr 9:59,388,554...59,488,186
Ensembl chr 9:59,388,258...59,486,618
JBrowse link
G Arl6ip5 ADP-ribosylation factor-like 6 interacting protein 5 increases response to substance
decreases expression
ISO ARL6IP5 protein results in increased susceptibility to Etoposide
Etoposide results in decreased expression of ARL6IP5
CTD PMID:19492242 NCBI chr 6:97,210,792...97,233,315
Ensembl chr 6:97,210,689...97,233,315
JBrowse link
G Arsa arylsulfatase A decreases expression EXP Etoposide results in decreased expression of ARSA mRNA CTD PMID:25270620 NCBI chr15:89,472,476...89,477,424
Ensembl chr15:89,472,476...89,477,425
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 affects response to substance ISO ASAH1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:41,340,646...41,397,644
Ensembl chr 8:41,340,197...41,374,773
JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO Etoposide results in increased phosphorylation of and results in increased activity of ATF2 protein CTD PMID:12663670 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639
JBrowse link
G Atf4 activating transcription factor 4 decreases expression EXP Etoposide results in decreased expression of ATF4 mRNA CTD PMID:25270620 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541
JBrowse link
G Atm ataxia telangiectasia mutated multiple interactions EXP
ISO
Etoposide results in increased phosphorylation of and results in increased activity of ATM protein
Etoposide results in increased phosphorylation of and affects the localization of ATM protein; pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of and affects the localization of ATM protein]
CTD PMID:22242153 PMID:26259609 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G Atp13a4 ATPase type 13A4 decreases expression EXP Etoposide results in decreased expression of ATP13A4 mRNA CTD PMID:25270620 NCBI chr16:29,389,103...29,544,864
Ensembl chr16:29,395,853...29,544,864
JBrowse link
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide affects response to substance ISO ATP1A1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:101,576,219...101,604,707
Ensembl chr 3:101,576,219...101,604,684
JBrowse link
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide decreases expression ISO Etoposide results in decreased expression of ATP1A2 mRNA CTD PMID:29397400 NCBI chr 1:172,271,709...172,298,064
Ensembl chr 1:172,271,709...172,298,064
JBrowse link
G Atp1b4 ATPase, (Na+)/K+ transporting, beta 4 polypeptide increases expression ISO Etoposide results in increased expression of ATP1B4 mRNA CTD PMID:29397400 NCBI chr  X:38,316,122...38,336,784
Ensembl chr  X:38,316,184...38,336,769
JBrowse link
G Atp5k ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in increased expression of ATP5ME protein CTD PMID:29733421 NCBI chr 5:108,433,246...108,434,399
Ensembl chr 5:108,433,244...108,434,448
JBrowse link
G Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit decreases expression EXP Etoposide results in decreased expression of ATP5O protein CTD PMID:29733421 NCBI chr16:91,925,223...91,931,630
Ensembl chr16:91,925,214...91,931,687
Ensembl chr16:91,925,214...91,931,687
JBrowse link
G Atp6v0a4 ATPase, H+ transporting, lysosomal V0 subunit A4 affects response to substance ISO ATP6V0A4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:38,048,483...38,124,586
Ensembl chr 6:38,048,483...38,124,586
JBrowse link
G Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A decreases expression
multiple interactions
EXP Etoposide results in decreased expression of ATP6V1A protein
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of ATP6V1A protein
CTD PMID:29733421 NCBI chr16:44,085,402...44,139,702
Ensembl chr16:44,085,402...44,139,705
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide decreases response to substance ISO ATP7A protein results in decreased susceptibility to Etoposide CTD PMID:17510416 NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926
JBrowse link
G Atr ataxia telangiectasia and Rad3 related increases phosphorylation EXP Etoposide results in increased phosphorylation of ATR protein CTD PMID:22242153 NCBI chr 9:95,857,597...95,953,217
Ensembl chr 9:95,857,597...95,951,781
JBrowse link
G Atxn1 ataxin 1 decreases expression ISO Etoposide results in decreased expression of ATXN1 mRNA CTD PMID:24211769 NCBI chr13:45,549,755...45,964,991
Ensembl chr13:45,549,755...45,965,008
JBrowse link
G Aurka aurora kinase A decreases expression EXP Etoposide results in decreased expression of AURKA mRNA CTD PMID:25270620 NCBI chr 2:172,356,190...172,370,886
Ensembl chr 2:172,356,190...172,370,535
JBrowse link
G Avpi1 arginine vasopressin-induced 1 affects response to substance ISO AVPI1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:42,123,275...42,128,993
Ensembl chr19:42,123,273...42,129,059
JBrowse link
G Avpr1a arginine vasopressin receptor 1A increases expression ISO Etoposide results in increased expression of AVPR1A mRNA CTD PMID:29397400 NCBI chr10:122,448,499...122,453,453
Ensembl chr10:122,448,499...122,453,452
JBrowse link
G Axl AXL receptor tyrosine kinase increases expression ISO Etoposide results in increased expression of AXL mRNA CTD PMID:21527772 NCBI chr 7:25,756,500...25,788,924
Ensembl chr 7:25,757,273...25,788,705
JBrowse link
G Bace2 beta-site APP-cleaving enzyme 2 affects response to substance ISO BACE2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr16:97,356,728...97,442,936
Ensembl chr16:97,356,742...97,442,936
JBrowse link
G Bag2 BCL2-associated athanogene 2 affects response to substance ISO BAG2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:33,745,484...33,757,750
Ensembl chr 1:33,745,484...33,757,795
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases activity
increases response to substance
affects response to substance
multiple interactions
affects expression
ISO
EXP
Etoposide results in increased activity of BAK1 protein
BAK1 protein results in increased susceptibility to Etoposide
BAK1 protein affects the susceptibility to Etoposide
nimesulide inhibits the reaction [Etoposide results in increased activity of BAK1 protein]
Etoposide affects the expression of BAK1 protein
CTD PMID:15215046 PMID:16077961 PMID:17688235 PMID:21745461 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bambi BMP and activin membrane-bound inhibitor affects response to substance ISO BAMBI protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:3,507,011...3,516,404
Ensembl chr18:3,507,923...3,516,404
JBrowse link
G Bax BCL2-associated X protein multiple interactions
increases expression
decreases folding
affects response to substance
ISO
EXP
[ABT-737 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein; [Cisplatin co-treated with Etoposide] affects the localization of BAX protein; [Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BAX protein; [IL4 protein co-treated with VCAM1 protein] inhibits the reaction [Etoposide results in decreased folding of BAX protein]; [RASSF1 co-treated with Etoposide] affects the folding of and results in increased activity of BAX protein; [trigonelline co-treated with Etoposide] results in increased expression of BAX protein; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]; Etoposide results in increased activity of and affects the localization of BAX protein; Etoposide results in increased cleavage of and results in increased expression of BAX protein; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] affects the localization of BAX protein]; nimesulide inhibits the reaction [Etoposide results in increased activity of and affects the localization of BAX protein]
Etoposide results in increased expression of BAX mRNA; Etoposide results in increased expression of BAX protein
BAX protein affects the susceptibility to Etoposide
CTD PMID:9815696 PMID:10620629 PMID:15131059 PMID:16077961 PMID:16120219 More... NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bbc3 BCL2 binding component 3 increases expression
multiple interactions
affects response to substance
ISO
EXP
Etoposide results in increased expression of BBC3 mRNA; Etoposide results in increased expression of BBC3 protein
entinostat promotes the reaction [Etoposide results in increased expression of BBC3 protein]; Etoposide promotes the reaction [entinostat results in increased expression of BBC3 protein]; Etoposide promotes the reaction [trichostatin A results in increased expression of BBC3 protein]; Etoposide promotes the reaction [UF010 compound results in increased expression of BBC3 protein]; trichostatin A promotes the reaction [Etoposide results in increased expression of BBC3 protein]; UF010 compound promotes the reaction [Etoposide results in increased expression of BBC3 protein]
BBC3 protein affects the susceptibility to Etoposide
CTD PMID:20477944 PMID:21801448 PMID:25699604 NCBI chr 7:16,308,398...16,318,334
Ensembl chr 7:16,308,393...16,318,205
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
ISO
EXP
[Doxorubicin co-treated with Vincristine co-treated with Etoposide co-treated with Mitotane] results in decreased expression of BCL2 protein; [Etoposide co-treated with Ciprofloxacin] results in decreased expression of BCL2 protein; [trigonelline co-treated with Etoposide] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2 protein results in decreased susceptibility to [Cisplatin co-treated with Etoposide]
Etoposide results in decreased expression of BCL2 mRNA; Etoposide results in decreased expression of BCL2 protein
[G(M3) Ganglioside results in increased expression of BCL2 protein] which results in decreased susceptibility to Etoposide; BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]; Lithium Chloride inhibits the reaction [Etoposide results in decreased expression of BCL2 mRNA]; Lithium Chloride inhibits the reaction [Etoposide results in decreased expression of BCL2 protein]
CTD PMID:8840993 PMID:9815696 PMID:12063570 PMID:15917659 PMID:16571667 More... NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions
affects expression
decreases response to substance
ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; BCL2L1 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2L1 protein results in decreased susceptibility to [Cisplatin co-treated with Etoposide]; Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]
Etoposide affects the expression of BCL2L1 protein
BCL2L1 protein results in decreased susceptibility to Etoposide
CTD PMID:8840993 PMID:10620629 PMID:11468182 PMID:15215046 PMID:15917659 More... NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bcl2l2 BCL2-like 2 decreases response to substance ISO BCL2L2 results in decreased susceptibility to Etoposide CTD PMID:14973057 NCBI chr14:54,883,366...54,890,858
Ensembl chr14:54,892,500...54,898,169
Ensembl chr14:54,892,500...54,898,169
JBrowse link
G Bcl6b B cell CLL/lymphoma 6, member B multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of BCL6B mRNA CTD PMID:29733421 NCBI chr11:70,224,127...70,229,798
Ensembl chr11:70,224,128...70,229,798
JBrowse link
G Bdnf brain derived neurotrophic factor increases expression
multiple interactions
ISO Etoposide results in increased expression of BDNF mRNA
HIPK2 mutant form inhibits the reaction [Etoposide results in increased expression of BDNF mRNA]
CTD PMID:20573984 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions
increases expression
increases cleavage
ISO CASP9 mutant form inhibits the reaction [Etoposide results in increased cleavage of BID protein]; Estradiol inhibits the reaction [Etoposide results in increased expression of BID mRNA] CTD PMID:19426747 PMID:21801448 NCBI chr 6:120,893,119...120,917,062
Ensembl chr 6:120,891,930...120,916,853
JBrowse link
G Bik BCL2-interacting killer increases response to substance ISO BIK protein results in increased susceptibility to Etoposide CTD PMID:16007125 NCBI chr15:83,526,790...83,544,635
Ensembl chr15:83,526,862...83,544,634
JBrowse link
G Bin1 bridging integrator 1 increases response to substance ISO BIN1 protein results in increased susceptibility to Etoposide CTD PMID:21447800 NCBI chr18:32,376,618...32,435,740
Ensembl chr18:32,377,230...32,435,737
JBrowse link
G Bin3 bridging integrator 3 affects response to substance ISO BIN3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:70,100,089...70,137,964
Ensembl chr14:70,100,105...70,138,206
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 affects response to substance
decreases response to substance
increases expression
ISO BIRC2 protein affects the susceptibility to Etoposide
BIRC2 protein results in decreased susceptibility to Etoposide
Etoposide results in increased expression of BIRC2 mRNA
CTD PMID:10815900 PMID:14970392 PMID:15050749 PMID:16217747 NCBI chr 9:7,818,226...7,837,131
Ensembl chr 9:7,818,227...7,837,064
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases response to substance
decreases expression
multiple interactions
ISO BIRC3 protein results in decreased susceptibility to Etoposide
Etoposide results in decreased expression of BIRC3 mRNA
[Etoposide co-treated with KN 62] results in decreased expression of BIRC3 protein
CTD PMID:14666661 PMID:15050749 PMID:16120219 NCBI chr 9:7,847,468...7,873,205
Ensembl chr 9:7,848,699...7,873,186
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases response to substance
increases expression
ISO [FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Etoposide; BIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Etoposide]; BIRC5 protein results in decreased susceptibility to [Cisplatin co-treated with Etoposide]; Estradiol inhibits the reaction [Etoposide results in increased expression of BIRC5 mRNA]
BIRC5 protein results in decreased susceptibility to Etoposide
CTD PMID:15917659 PMID:16322251 PMID:16364925 PMID:16382892 PMID:19211844 More... NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 (livin) decreases response to substance ISO BIRC7 protein results in decreased susceptibility to Etoposide CTD PMID:17437058 NCBI chr 2:180,928,609...180,934,010
Ensembl chr 2:180,929,023...180,934,010
JBrowse link
G Blm Bloom syndrome, RecQ like helicase decreases expression ISO Etoposide results in decreased expression of BLM mRNA CTD PMID:24211769 NCBI chr 7:80,454,993...80,535,148
Ensembl chr 7:80,454,733...80,535,119
JBrowse link
G Bmp6 bone morphogenetic protein 6 multiple interactions ISO Etoposide inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Brca1 breast cancer 1, early onset multiple interactions
increases expression
decreases expression
ISO BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD52 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of RAD54L protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC2 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC3 protein]; BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of XRCC4 protein]; pifithrin inhibits the reaction [Etoposide results in increased expression of and affects the localization of BRCA1 protein]
Etoposide results in increased expression of BRCA1 protein
Etoposide results in decreased expression of BRCA1 mRNA
CTD PMID:15607317 PMID:16417649 PMID:26259609 NCBI chr11:101,488,761...101,551,955
Ensembl chr11:101,488,764...101,551,955
JBrowse link
G Bscl2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) increases expression EXP Etoposide results in increased expression of BSCL2 mRNA CTD PMID:22003191 PMID:25270620 NCBI chr19:8,837,467...8,848,683
Ensembl chr19:8,837,467...8,848,683
JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions
increases expression
EXP
ISO
TRP53 protein affects the reaction [Etoposide results in increased expression of BTG2 mRNA]
TP53 promotes the reaction [Etoposide results in increased expression of BTG2 protein]
Etoposide results in increased expression of BTG2 mRNA; Etoposide results in increased expression of BTG2 protein
CTD PMID:21382384 PMID:22003191 PMID:24211769 PMID:27358234 NCBI chr 1:134,074,865...134,079,155
Ensembl chr 1:134,075,170...134,079,120
JBrowse link
G Btg3 BTG anti-proliferation factor 3 decreases expression ISO Etoposide results in decreased expression of BTG3 mRNA CTD PMID:24211769 NCBI chr16:78,359,860...78,377,181
Ensembl chr16:78,332,637...78,377,192
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase decreases expression ISO Etoposide results in decreased expression of BUB1 mRNA CTD PMID:16120219 NCBI chr 2:127,800,197...127,831,859
Ensembl chr 2:127,801,122...127,831,865
JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase decreases expression ISO Etoposide results in decreased expression of BUB1B mRNA CTD PMID:16120219 NCBI chr 2:118,598,202...118,641,592
Ensembl chr 2:118,598,211...118,641,591
JBrowse link
G C1qbp complement component 1, q subcomponent binding protein decreases response to substance ISO C1QBP protein results in decreased susceptibility to Etoposide CTD PMID:25354864 NCBI chr11:70,977,846...70,983,026
Ensembl chr11:70,977,836...70,983,026
JBrowse link
G Cab39 calcium binding protein 39 decreases expression ISO Etoposide results in decreased expression of CAB39 mRNA CTD PMID:17374387 NCBI chr 1:85,793,441...85,851,577
Ensembl chr 1:85,793,441...85,851,576
JBrowse link
G Cadps2 Ca2+-dependent activator protein for secretion 2 affects response to substance ISO CADPS2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:23,262,773...23,841,175
Ensembl chr 6:23,262,773...23,839,421
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions
decreases response to substance
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in decreased susceptibility to Etoposide] CTD PMID:16222118 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Calm1 calmodulin 1 increases expression ISO Etoposide results in increased expression of CALM1 mRNA CTD PMID:29397400 NCBI chr12:100,199,435...100,209,824
Ensembl chr12:100,199,435...100,209,814
JBrowse link
G Card10 caspase recruitment domain family, member 10 multiple interactions
increases expression
ISO Estradiol inhibits the reaction [Etoposide results in increased expression of CARD10 mRNA] CTD PMID:19426747 NCBI chr15:78,775,123...78,803,072
Ensembl chr15:78,775,138...78,803,042
JBrowse link
G Casp2 caspase 2 increases expression
increases splicing
ISO Etoposide results in increased expression of CASP2 mRNA alternative form
Etoposide results in increased splicing of CASP2 mRNA
CTD PMID:14757846 NCBI chr 6:42,264,902...42,282,508
Ensembl chr 6:42,264,985...42,282,508
JBrowse link
G Casp3 caspase 3 affects expression
increases cleavage
multiple interactions
increases activity
increases expression
ISO
EXP
Etoposide affects the expression of CASP3 protein
Etoposide results in increased cleavage of CASP3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]; [Etoposide co-treated with Mifepristone] results in increased activity of CASP3 protein; [RASSF1 co-treated with Etoposide] results in increased cleavage of CASP3 protein; [STAT1 protein results in increased activity of CASP3 protein] which results in increased susceptibility to Etoposide; [trigonelline co-treated with Etoposide] results in increased cleavage of CASP3 protein; Acetylcysteine inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]; Dehydroascorbic Acid promotes the reaction [Etoposide results in increased activity of CASP3 protein]; Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Nanotubes, Carbon results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Silver results in increased activity of CASP3 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP3 protein; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Oxygen deficiency inhibits the reaction [Etoposide results in increased expression of CASP3 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP3 protein]; pifithrin promotes the reaction [Etoposide results in increased cleavage of CASP3 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TMSB4X protein inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]
[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein; Etoposide results in increased activity of CASP3 protein
2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP3 protein; HIPK2 gene mutant form promotes the reaction [Etoposide results in increased activity of CASP3 protein]; Metoclopramide inhibits the reaction [Etoposide results in increased activity of CASP3 protein]
CTD PMID:8840993 PMID:10759716 PMID:12871656 PMID:15215046 PMID:15924153 More... NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO
EXP
[STAT1 protein results in increased activity of CASP7 protein] which results in increased susceptibility to Etoposide; benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; palbociclib inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; pifithrin promotes the reaction [Etoposide results in increased activity of CASP7 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased activity of CASP7 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased activity of CASP7 protein]
2-tert-butylhydroquinone inhibits the reaction [Etoposide results in increased activity of CASP7 protein]
CTD PMID:18056177 PMID:18649362 PMID:20299546 PMID:21801448 PMID:22275372 More... NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 multiple interactions
increases response to substance
increases cleavage
increases activity
decreases response to substance
ISO 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of CASP3 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] inhibits the reaction [CASP8 protein mutant form results in decreased susceptibility to Etoposide]; acetyl-leucyl-glutamyl-histidyl-aspartal inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP3 protein]; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP9 protein]; Etoposide results in increased cleavage of and results in increased activity of CASP8 protein; Etoposide results in increased expression of and results in increased cleavage of CASP8 protein; Lithium inhibits the reaction [Etoposide results in increased activity of CASP8 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP8 protein]; TP73 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP8 protein]
CASP8 protein results in increased susceptibility to Etoposide
CTD PMID:15475000 PMID:21745461 PMID:21801448 PMID:22010212 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
increases activity
affects expression
ISO [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; [Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein; CASP8 mutant form inhibits the reaction [Etoposide results in increased cleavage of CASP9 protein]; CASP9 mutant form inhibits the reaction [Etoposide results in increased cleavage of BID protein]; Etoposide results in increased cleavage of and results in increased activity of CASP9 protein; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of CASP9 protein]; MYC protein promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]; Nicotine inhibits the reaction [[Cisplatin co-treated with Etoposide] results in increased activity of CASP9 protein]; nimesulide inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; TMSB4X protein inhibits the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP9 protein]; wortmannin promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]
Etoposide affects the expression of CASP9 protein
CTD PMID:12925536 PMID:15215046 PMID:16364925 PMID:16799960 PMID:17935137 More... NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Casq2 calsequestrin 2 decreases expression ISO Etoposide results in decreased expression of CASQ2 mRNA CTD PMID:29397400 NCBI chr 3:102,086,415...102,146,514
Ensembl chr 3:102,086,415...102,146,514
JBrowse link
G Cast calpastatin multiple interactions ISO CAST inhibits the reaction [Etoposide results in increased degradation of AR protein] CTD PMID:18726991 NCBI chr13:74,692,366...74,808,874
Ensembl chr13:74,692,368...74,808,810
JBrowse link
G Cat catalase increases response to substance
increases activity
ISO CAT results in increased susceptibility to Etoposide
Etoposide results in increased activity of CAT protein
CTD PMID:21689642 PMID:25451571 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Ccdc51 coiled-coil domain containing 51 decreases expression ISO Etoposide results in decreased expression of CCDC51 mRNA CTD PMID:24211769 NCBI chr 9:109,082,496...109,093,363
Ensembl chr 9:109,082,493...109,092,489
JBrowse link
G Ccdc6 coiled-coil domain containing 6 increases response to substance
decreases response to substance
ISO CCDC6 results in increased susceptibility to Etoposide
CCDC6 results in decreased susceptibility to Etoposide
CTD PMID:22363533 PMID:22655027 NCBI chr10:70,096,878...70,193,200
Ensembl chr10:70,097,121...70,193,200
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 increases expression ISO Etoposide results in increased expression of CCL3 protein CTD PMID:10540334 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Etoposide results in increased expression of CCN2 mRNA CTD PMID:29397400 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Ccna2 cyclin A2 multiple interactions
decreases expression
ISO Etoposide affects the expression of and affects the localization of CCNA2 protein
Etoposide results in decreased expression of CCNA2 mRNA; Etoposide results in decreased expression of CCNA2 protein
CTD PMID:16120219 PMID:17390037 NCBI chr 3:36,564,865...36,573,038
Ensembl chr 3:36,564,865...36,572,150
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Etoposide results in decreased expression of CCNB1 mRNA; Etoposide results in decreased expression of CCNB1 protein CTD PMID:16120219 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO Etoposide results in increased expression of CCND1 mRNA CTD PMID:16120219 NCBI chr 7:144,929,931...144,939,831
Ensembl chr 7:144,929,931...144,939,925
JBrowse link
G Ccng1 cyclin G1 increases expression EXP Etoposide results in increased expression of CCNG1 mRNA CTD PMID:25270620 NCBI chr11:40,748,552...40,755,309
Ensembl chr11:40,748,552...40,755,311
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Etoposide results in increased expression of CCNG2 mRNA CTD PMID:18754885 NCBI chr 5:93,267,573...93,276,231
Ensembl chr 5:93,267,257...93,276,231
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO Etoposide results in increased expression of CCS mRNA CTD PMID:21527772 NCBI chr19:4,825,366...4,839,356
Ensembl chr19:4,825,366...4,839,332
JBrowse link
G Cct8 chaperonin containing Tcp1, subunit 8 (theta) multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of CCT8 protein CTD PMID:29733421 NCBI chr16:87,483,325...87,495,869
Ensembl chr16:87,483,326...87,495,873
JBrowse link
G Cd274 CD274 antigen increases expression ISO Etoposide results in increased expression of CD274 protein CTD PMID:17920123 NCBI chr19:29,362,107...29,388,095
Ensembl chr19:29,367,455...29,388,095
JBrowse link
G Cd40lg CD40 ligand multiple interactions
decreases response to substance
ISO CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]
CD40LG protein results in decreased susceptibility to Etoposide
CTD PMID:16545138 NCBI chr  X:57,212,143...57,224,042
Ensembl chr  X:57,212,143...57,224,042
JBrowse link
G Cd44 CD44 antigen affects response to substance
multiple interactions
ISO CD44 protein affects the susceptibility to Etoposide
[[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide]
CTD PMID:15215046 PMID:19047049 NCBI chr 2:102,811,141...102,901,669
Ensembl chr 2:102,811,141...102,901,665
JBrowse link
G Cd55 CD55 molecule, decay accelerating factor for complement affects response to substance ISO CD55 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:130,429,798...130,465,009
Ensembl chr 1:130,439,027...130,462,744
JBrowse link
G Cd59b CD59b antigen multiple interactions ISO [Cisplatin co-treated with Etoposide] results in decreased expression of CD59 protein CTD PMID:21826740 NCBI chr 2:104,069,781...104,085,790
Ensembl chr 2:104,069,849...104,091,187
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO Etoposide results in decreased expression of CDC25A mRNA CTD PMID:24211769 NCBI chr 9:109,875,518...109,893,895
Ensembl chr 9:109,875,579...109,893,895
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO Etoposide results in decreased expression of CDC25C mRNA CTD PMID:16120219 NCBI chr18:34,732,993...34,751,564
Ensembl chr18:34,732,993...34,751,533
JBrowse link
G Cdc42bpg CDC42 binding protein kinase gamma (DMPK-like) increases expression EXP Etoposide results in increased expression of CDC42BPG mRNA CTD PMID:25270620 NCBI chr19:6,306,253...6,325,653
Ensembl chr19:6,306,456...6,325,652
JBrowse link
G Cdc45 cell division cycle 45 decreases expression ISO Etoposide results in decreased expression of CDC45 mRNA CTD PMID:16120219 NCBI chr16:18,780,447...18,811,972
Ensembl chr16:18,780,447...18,811,987
JBrowse link
G Cdc6 cell division cycle 6 decreases expression ISO Etoposide results in decreased expression of CDC6 mRNA CTD PMID:16120219 NCBI chr11:98,907,709...98,923,942
Ensembl chr11:98,907,801...98,923,940
JBrowse link
G Cdk2 cyclin-dependent kinase 2 multiple interactions
increases expression
affects response to substance
ISO BRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein]; CDK2 affects the reaction [Etoposide results in increased phosphorylation of TPI1 protein]
CDK2 protein affects the susceptibility to Etoposide
CTD PMID:16217747 PMID:16417649 PMID:20149834 NCBI chr10:128,697,938...128,705,051
Ensembl chr10:128,697,939...128,705,031
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
ISO
EXP
[Etoposide results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein; [RASSF1 co-treated with Etoposide] results in increased expression of CDKN1A protein; CDKN1A mutant form inhibits the reaction [Aspirin inhibits the reaction [Etoposide results in increased activity of CASP3 protein]]; CDKN1A protein affects the reaction [Etoposide results in decreased expression of UBE2C protein]; entinostat promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; Etoposide promotes the reaction [entinostat results in increased expression of CDKN1A protein]; Etoposide promotes the reaction [trichostatin A results in increased expression of CDKN1A protein]; Etoposide promotes the reaction [UF010 compound results in increased expression of CDKN1A protein]; KEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein]; resveratrol inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]; TP53 promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [[Etoposide results in increased susceptibility to Benzo(a)pyrene] which results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; trichostatin A promotes the reaction [Etoposide results in increased expression of CDKN1A protein]; UF010 compound promotes the reaction [Etoposide results in increased expression of CDKN1A protein]
Etoposide results in increased expression of CDKN1A mRNA; Etoposide results in increased expression of CDKN1A protein
[CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of CDKN1A protein]; TRP53 affects the reaction [Etoposide results in increased expression of CDKN1A mRNA]
cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]; Etoposide promotes the reaction [Niacin deficiency results in increased expression of CDKN1A protein]; mithramycin A inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]; salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN1A mRNA]
CTD PMID:14601052 PMID:16120219 PMID:16882877 PMID:17516866 PMID:21212465 More... NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO Etoposide results in increased expression of CDKN1B protein
wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein]
CTD PMID:17935137 NCBI chr 6:134,920,401...134,925,525
Ensembl chr 6:134,920,401...134,925,513
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases expression
multiple interactions
ISO
EXP
Etoposide results in increased expression of CDKN2A mRNA
[CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of CDKN1A protein]; [CDKN2A gene mutant form results in increased expression of CDKN2A protein alternative form] inhibits the reaction [Etoposide results in increased expression of TRP53 protein]
cordycepin inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]; mithramycin A inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]; salubrinal inhibits the reaction [Etoposide results in increased expression of CDKN2A mRNA]
CTD PMID:21526190 PMID:23690541 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression ISO Etoposide results in decreased expression of CDKN3 mRNA CTD PMID:16120219 NCBI chr14:46,760,461...46,771,530
Ensembl chr14:46,760,541...46,771,669
JBrowse link
G Ceacam1 carcinoembryonic antigen-related cell adhesion molecule 1 increases expression ISO Etoposide results in increased expression of CEACAM1 mRNA CTD PMID:17374387 NCBI chr 7:25,461,702...25,477,647
Ensembl chr 7:25,461,707...25,477,603
JBrowse link
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha decreases expression
increases degradation
ISO Etoposide results in decreased expression of CEBPA mRNA; Etoposide results in decreased expression of CEBPA protein
Etoposide results in increased degradation of CEBPA protein
CTD PMID:19662097 NCBI chr 7:35,119,293...35,121,928
Ensembl chr 7:35,119,293...35,121,928
JBrowse link
G Cebpz CCAAT/enhancer binding protein zeta decreases expression ISO Etoposide results in decreased expression of CEBPZ mRNA CTD PMID:17374387 NCBI chr17:78,919,003...78,937,070
Ensembl chr17:78,919,006...78,937,066
JBrowse link
G Cel carboxyl ester lipase increases expression ISO Etoposide results in increased expression of CEL mRNA CTD PMID:21527772 NCBI chr 2:28,555,819...28,563,403
Ensembl chr 2:28,555,795...28,563,403
JBrowse link
G Cenpf centromere protein F decreases expression ISO Etoposide results in decreased expression of CENPF mRNA CTD PMID:16120219 NCBI chr 1:189,640,606...189,688,107
Ensembl chr 1:189,640,606...189,688,086
JBrowse link
G Cercam cerebral endothelial cell adhesion molecule increases expression EXP Etoposide results in increased expression of CERCAM mRNA CTD PMID:25270620 NCBI chr 2:29,845,094...29,882,840
Ensembl chr 2:29,869,164...29,882,840
JBrowse link
G Ces1d carboxylesterase 1D increases expression EXP Etoposide results in increased expression of CES1D mRNA CTD PMID:25270620 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Ces2a carboxylesterase 2A increases expression EXP Etoposide results in increased expression of CES2A mRNA CTD PMID:25270620 NCBI chr 8:104,734,003...104,741,634
Ensembl chr 8:104,734,003...104,741,634
JBrowse link
G Ces2e carboxylesterase 2E increases expression EXP Etoposide results in increased expression of CES2E mRNA CTD PMID:25270620 NCBI chr 8:104,926,260...104,934,672
Ensembl chr 8:104,926,260...104,934,672
JBrowse link
G Ces2g carboxylesterase 2G increases expression EXP Etoposide results in increased expression of CES2G mRNA CTD PMID:25270620 NCBI chr 8:104,961,596...104,969,537
Ensembl chr 8:104,961,718...104,969,537
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator increases expression ISO Etoposide results in increased expression of CFLAR protein CTD PMID:14601052 NCBI chr 1:58,711,311...58,758,884
Ensembl chr 1:58,711,508...58,758,884
JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 increases expression EXP Etoposide results in increased expression of CGREF1 mRNA CTD PMID:25270620 NCBI chr 5:30,933,143...30,945,480
Ensembl chr 5:30,933,143...30,945,591
JBrowse link
G Chac1 ChaC, cation transport regulator 1 decreases expression EXP Etoposide results in decreased expression of CHAC1 mRNA CTD PMID:25270620 NCBI chr 2:119,351,242...119,354,326
Ensembl chr 2:119,351,229...119,354,381
JBrowse link
G Chaf1a chromatin assembly factor 1, subunit A (p150) decreases expression ISO Etoposide results in decreased expression of CHAF1A mRNA CTD PMID:24211769 NCBI chr17:56,040,416...56,068,026
Ensembl chr17:56,040,439...56,072,289
JBrowse link
G Chek1 checkpoint kinase 1 affects response to substance
multiple interactions
ISO CHEK1 protein affects the susceptibility to Etoposide
TP53 protein affects the reaction [CHEK1 protein affects the susceptibility to Etoposide]
CTD PMID:18698031 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation
multiple interactions
EXP
ISO
Etoposide results in increased phosphorylation of CHEK2 protein
4-fluoro-2-(4-(4-(2-hydroxypropan-2-yl)pyrrolidin-3-ylamino)-6,7-dimethoxyquinazolin-2-yl)phenol inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein]; pifithrin inhibits the reaction [Etoposide results in increased phosphorylation of CHEK2 protein]
CTD PMID:21186793 PMID:22242153 PMID:26259609 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145
JBrowse link
G Chil1 chitinase-like 1 decreases response to substance ISO CHI3L1 results in decreased susceptibility to Etoposide CTD PMID:20506295 NCBI chr 1:134,182,156...134,190,031
Ensembl chr 1:134,182,176...134,190,181
JBrowse link
G Ciapin1 cytokine induced apoptosis inhibitor 1 decreases response to substance ISO CIAPIN1 protein results in decreased susceptibility to Etoposide CTD PMID:18389626 NCBI chr 8:94,819,818...94,838,830
Ensembl chr 8:94,819,804...94,838,358
JBrowse link
G Ckm creatine kinase, muscle decreases expression ISO Etoposide results in decreased expression of CKM mRNA CTD PMID:29397400 NCBI chr 7:19,411,094...19,421,583
Ensembl chr 7:19,404,776...19,422,841
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1, ubiquitous affects response to substance ISO CKMT1B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:121,357,773...121,363,737
Ensembl chr 2:121,357,714...121,363,737
JBrowse link
G Coa7 cytochrome c oxidase assembly factor 7 decreases expression ISO Etoposide results in decreased expression of COA7 mRNA CTD PMID:24211769 NCBI chr 4:108,328,152...108,340,718
Ensembl chr 4:108,328,140...108,341,544
JBrowse link
G Cobl cordon-bleu WH2 repeat decreases expression EXP Etoposide results in decreased expression of COBL mRNA CTD PMID:25270620 NCBI chr11:12,236,676...12,465,022
Ensembl chr11:12,236,608...12,464,960
JBrowse link
G Col15a1 collagen, type XV, alpha 1 affects response to substance ISO COL15A1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:47,207,655...47,313,167
Ensembl chr 4:47,208,161...47,313,167
JBrowse link
G Col4a1 collagen, type IV, alpha 1 decreases expression EXP Etoposide results in decreased expression of COL4A1 mRNA CTD PMID:25270620 NCBI chr 8:11,198,423...11,312,889
Ensembl chr 8:11,198,423...11,312,826
JBrowse link
G Col9a3 collagen, type IX, alpha 3 affects response to substance ISO COL9A3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:180,598,102...180,622,192
Ensembl chr 2:180,597,790...180,622,189
JBrowse link
G Cox6a2 cytochrome c oxidase subunit 6A2 decreases expression ISO Etoposide results in decreased expression of COX6A2 mRNA CTD PMID:29397400 NCBI chr 7:128,205,435...128,206,366
Ensembl chr 7:128,205,435...128,206,387
JBrowse link
G Cps1 carbamoyl-phosphate synthetase 1 affects response to substance ISO CPS1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:67,122,426...67,231,267
Ensembl chr 1:67,123,026...67,231,259
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Etoposide results in decreased expression of CPT2 mRNA CTD PMID:24211769 NCBI chr 4:107,903,982...107,923,589
Ensembl chr 4:107,903,981...107,923,610
JBrowse link
G Crabp2 cellular retinoic acid binding protein II increases expression ISO Etoposide results in increased expression of CRABP2 mRNA CTD PMID:21527772 NCBI chr 3:87,948,693...87,953,372
Ensembl chr 3:87,948,666...87,953,376
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP
ISO
Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein; HIPK2 gene mutant form inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein] CTD PMID:20573984 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crem cAMP responsive element modulator affects response to substance ISO CREM protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:3,266,354...3,337,773
Ensembl chr18:3,266,048...3,337,748
JBrowse link
G Crip2 cysteine rich protein 2 increases expression EXP Etoposide results in increased expression of CRIP2 mRNA CTD PMID:25270620 NCBI chr12:113,140,236...113,145,506
Ensembl chr12:113,140,236...113,145,506
JBrowse link
G Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 affects response to substance ISO CSGALNACT1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:68,356,781...68,735,621
Ensembl chr 8:68,356,781...68,735,146
JBrowse link
G Cth cystathionase (cystathionine gamma-lyase) affects response to substance ISO CTH protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:157,894,248...157,925,081
Ensembl chr 3:157,894,248...157,925,077
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide] CTD PMID:19047049 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 decreases expression ISO Etoposide results in decreased expression of CXCL12 mRNA; Etoposide results in decreased expression of CXCL12 protein CTD PMID:22363485 NCBI chr 6:117,168,535...117,181,368
Ensembl chr 6:117,168,535...117,181,367
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression
multiple interactions
ISO Etoposide results in increased expression of CXCL8 mRNA; Etoposide results in increased expression of CXCL8 protein
SB 203580 inhibits the reaction [Etoposide results in increased expression of CXCL8 protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Etoposide results in increased expression of CXCL8 protein]
CTD PMID:10540334 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Etoposide affects the localization of CYCS protein CTD PMID:10759716 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; TP53 protein promotes the reaction [Etoposide promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]]; TP53 protein promotes the reaction [Etoposide results in increased expression of CYP1A1 protein]
Etoposide results in increased expression of CYP1A1 mRNA; Etoposide results in increased expression of CYP1A1 protein
CTD PMID:29471073 PMID:31542801 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Etoposide results in increased expression of CYP1A2 mRNA CTD PMID:31542801 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 decreases response to substance ISO CYP26A1 protein results in decreased susceptibility to Etoposide CTD PMID:15703382 NCBI chr19:37,697,738...37,701,536
Ensembl chr19:37,697,798...37,701,536
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression ISO Etoposide results in increased expression of CYP27B1 mRNA CTD PMID:17716971 NCBI chr10:127,048,246...127,054,884
Ensembl chr10:127,048,250...127,053,006
JBrowse link
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 increases expression EXP Etoposide results in increased expression of CYP2C29 mRNA CTD PMID:25270620 NCBI chr19:39,287,044...39,330,713
Ensembl chr19:39,269,405...39,330,713
JBrowse link
G Cyp2c55 cytochrome P450, family 2, subfamily c, polypeptide 55 increases expression EXP Etoposide results in increased expression of CYP2C55 mRNA CTD PMID:25270620 NCBI chr19:39,006,940...39,042,690
Ensembl chr19:39,007,019...39,042,693
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression EXP Etoposide results in decreased expression of CYP2S1 mRNA CTD PMID:25270620 NCBI chr 7:25,802,469...25,816,525
Ensembl chr 7:25,802,475...25,816,913
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 affects response to substance
decreases methylation
ISO CYP3A5 gene polymorphism affects the susceptibility to Etoposide
CYP3A5 protein results in decreased methylation of Etoposide
CTD PMID:8114683 PMID:12969965 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp3a44 cytochrome P450, family 3, subfamily a, polypeptide 44 increases expression EXP Etoposide results in increased expression of CYP3A44 mRNA CTD PMID:25270620 NCBI chr 5:145,773,983...145,805,891
Ensembl chr 5:145,773,983...145,805,874
JBrowse link
G Cyren cell cycle regulator of NHEJ affects localization ISO Etoposide affects the localization of CYREN protein alternative form CTD PMID:24610814 NCBI chr 6:34,871,771...34,878,065
Ensembl chr 6:34,871,771...34,878,060
JBrowse link
G Dab2 disabled 2, mitogen-responsive phosphoprotein affects response to substance ISO DAB2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:6,299,788...6,440,715
Ensembl chr15:6,299,788...6,440,712
JBrowse link
G Dbf4 DBF4 zinc finger decreases expression EXP Etoposide results in decreased expression of DBF4 mRNA CTD PMID:25270620 NCBI chr 5:8,396,969...8,422,725
Ensembl chr 5:8,396,973...8,422,716
JBrowse link
G Dbn1 drebrin 1 affects response to substance ISO DBN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:55,473,428...55,488,126
Ensembl chr13:55,473,429...55,488,111
JBrowse link
G Dcaf4 DDB1 and CUL4 associated factor 4 increases expression EXP Etoposide results in increased expression of DCAF4 mRNA CTD PMID:25270620 NCBI chr12:83,520,447...83,541,994
Ensembl chr12:83,520,466...83,541,920
JBrowse link
G Dct dopachrome tautomerase affects response to substance ISO DCT protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:118,012,790...118,052,246
Ensembl chr14:118,012,790...118,052,244
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 affects response to substance ISO DDIT4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:59,949,675...59,951,770
Ensembl chr10:59,949,669...59,951,834
JBrowse link
G Ddr1 discoidin domain receptor family, member 1 increases expression EXP Etoposide results in increased expression of DDR1 mRNA CTD PMID:25270620 NCBI chr17:35,681,567...35,704,741
Ensembl chr17:35,681,567...35,704,621
JBrowse link
G Des desmin decreases expression ISO Etoposide results in decreased expression of DES mRNA CTD PMID:29397400 NCBI chr 1:75,360,292...75,368,579
Ensembl chr 1:75,360,329...75,368,579
JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 affects response to substance ISO DKK3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:112,116,019...112,159,482
Ensembl chr 7:112,116,017...112,159,057
JBrowse link
G Dmd dystrophin, muscular dystrophy affects response to substance
decreases expression
ISO DMD protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of DMD mRNA
CTD PMID:16217747 PMID:29397400 NCBI chr  X:82,814,664...85,205,050
Ensembl chr  X:82,948,870...85,206,141
JBrowse link
G Dmrt1 doublesex and mab-3 related transcription factor 1 decreases expression EXP Etoposide results in decreased expression of DMRT1 mRNA CTD PMID:25270620 NCBI chr19:25,505,618...25,604,328
Ensembl chr19:25,505,618...25,604,329
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 decreases response to substance ISO DNMT1 protein results in decreased susceptibility to Etoposide CTD PMID:18314485 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases response to substance ISO DNMT3B protein results in decreased susceptibility to Etoposide CTD PMID:18314485 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730
JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions ISO Etoposide promotes the reaction [[DPP7 protein results in increased cleavage of Dipeptides] which results in increased abundance of 4-nitroaniline] CTD PMID:16725115 NCBI chr 2:25,352,290...25,356,389
Ensembl chr 2:25,352,276...25,356,359
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases expression EXP Etoposide results in decreased expression of DPYSL2 protein CTD PMID:29733421 NCBI chr14:66,802,864...66,911,041
Ensembl chr14:66,802,864...66,868,688
JBrowse link
G Dpysl4 dihydropyrimidinase-like 4 increases expression ISO Etoposide results in increased expression of DPYSL4 mRNA CTD PMID:21527772 NCBI chr 7:139,085,981...139,101,795
Ensembl chr 7:139,086,001...139,102,704
JBrowse link
G Dusp2 dual specificity phosphatase 2 affects response to substance ISO DUSP2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:127,336,159...127,338,377
Ensembl chr 2:127,336,159...127,338,376
JBrowse link
G Dusp4 dual specificity phosphatase 4 affects response to substance
increases expression
ISO DUSP4 protein affects the susceptibility to Etoposide
Etoposide results in increased expression of DUSP4 mRNA
CTD PMID:16217747 PMID:29397400 NCBI chr 8:34,807,610...34,819,894
Ensembl chr 8:34,807,297...34,819,894
JBrowse link
G E130309D02Rik RIKEN cDNA E130309D02 gene decreases expression ISO Etoposide results in decreased expression of C7ORF26 mRNA CTD PMID:24211769 NCBI chr 5:143,301,072...143,315,387
Ensembl chr 5:143,301,195...143,315,360
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO E2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA]; Etoposide promotes the reaction [E2F1 protein binds to HIC1 promoter] CTD PMID:19491197 NCBI chr 2:154,559,400...154,569,892
Ensembl chr 2:154,559,407...154,569,892
JBrowse link
G Edn1 endothelin 1 multiple interactions ISO EDN1 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide] CTD PMID:24184161 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Ednrb endothelin receptor type B decreases expression EXP Etoposide results in decreased expression of EDNRB mRNA CTD PMID:25270620 NCBI chr14:103,814,615...103,844,508
Ensembl chr14:103,814,625...103,844,402
JBrowse link
G Efs embryonal Fyn-associated substrate increases expression EXP Etoposide results in increased expression of EFS mRNA CTD PMID:25270620 NCBI chr14:54,916,543...54,926,788
Ensembl chr14:54,916,535...54,926,126
JBrowse link
G Egf epidermal growth factor multiple interactions ISO [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Etoposide CTD PMID:16969495 NCBI chr 3:129,677,574...129,755,322
Ensembl chr 3:129,677,565...129,755,316
JBrowse link
G Egfl8 EGF-like domain 8 affects response to substance ISO EGFL8 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:34,613,349...34,616,562
Ensembl chr17:34,613,349...34,615,971
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO Etoposide results in decreased expression of EGFR mRNA; Etoposide results in decreased expression of EGFR protein CTD PMID:15228094 NCBI chr11:16,752,203...16,913,907
Ensembl chr11:16,752,203...16,918,158
JBrowse link
G Ei24 etoposide induced 2.4 mRNA increases expression ISO Etoposide results in increased expression of EI24 mRNA CTD PMID:17374387 NCBI chr 9:36,779,153...36,797,334
Ensembl chr 9:36,779,159...36,797,393
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2, subunit 2 (beta) decreases expression EXP Etoposide results in decreased expression of EIF2S2 mRNA CTD PMID:25270620 NCBI chr 2:154,871,410...154,892,906
Ensembl chr 2:154,871,410...154,892,935
JBrowse link
G Eif3a eukaryotic translation initiation factor 3, subunit A increases response to substance ISO
EXP
EIF3A results in increased susceptibility to Etoposide CTD PMID:21610145 NCBI chr19:60,761,116...60,790,693
Ensembl chr19:60,761,117...60,790,658
JBrowse link
G Emp1 epithelial membrane protein 1 increases expression ISO Etoposide results in increased expression of EMP1 mRNA CTD PMID:21527772 NCBI chr 6:135,362,550...135,383,173
Ensembl chr 6:135,362,545...135,383,173
JBrowse link
G Emp2 epithelial membrane protein 2 affects response to substance ISO EMP2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr16:10,281,749...10,313,968
Ensembl chr16:10,281,749...10,313,968
JBrowse link
G Emp3 epithelial membrane protein 3 increases expression ISO Etoposide results in increased expression of EMP3 mRNA CTD PMID:21527772 NCBI chr 7:45,918,023...45,921,426
Ensembl chr 7:45,918,023...45,921,404
JBrowse link
G En2 engrailed 2 affects response to substance ISO EN2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:28,165,696...28,172,190
Ensembl chr 5:28,165,694...28,172,166
JBrowse link
G Eno1 enolase 1, alpha non-neuron decreases expression EXP Etoposide results in decreased expression of ENO1 protein CTD PMID:29733421 NCBI chr 4:150,236,708...150,248,879
Ensembl chr 4:150,236,721...150,248,879
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression EXP Etoposide results in decreased expression of ENTPD2 mRNA CTD PMID:25270620 NCBI chr 2:25,395,874...25,401,323
Ensembl chr 2:25,395,874...25,401,321
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of BCL2L1 protein] inhibits the reaction [Etoposide results in increased activity of CASP3 protein]; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide; [[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in decreased susceptibility to Etoposide]; resveratrol inhibits the reaction [[[[Hyaluronic Acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in decreased susceptibility to Etoposide] CTD PMID:19047049 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077
JBrowse link
G Epb41l3 erythrocyte membrane protein band 4.1 like 3 affects response to substance ISO EPB41L3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr17:69,075,647...69,289,991
Ensembl chr17:69,075,683...69,289,989
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases expression EXP Etoposide results in increased expression of EPHX1 mRNA CTD PMID:21382384 PMID:25270620 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Epm2aip1 EPM2A (laforin) interacting protein 1 increases expression ISO Etoposide results in increased expression of EPM2AIP1 mRNA CTD PMID:17374387 NCBI chr 9:111,271,845...111,279,093
Ensembl chr 9:111,271,929...111,279,093
JBrowse link
G Epo erythropoietin multiple interactions ISO EPO protein results in increased susceptibility to [Organoplatinum Compounds co-treated with Etoposide] CTD PMID:18403296 NCBI chr 5:137,483,020...137,485,816
Ensembl chr 5:137,483,020...137,533,242
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions
decreases expression
decreases response to substance
affects response to substance
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; [ERBB2 results in increased expression of ABCG2] which results in decreased susceptibility to Etoposide; ABCG2 mutant form inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; Curcumin analog inhibits the reaction [ERBB2 protein results in decreased susceptibility to Etoposide]
Etoposide results in decreased expression of ERBB2 mRNA
ERBB2 protein results in decreased susceptibility to Etoposide; ERBB2 results in decreased susceptibility to Etoposide
ERBB2 protein affects the susceptibility to Etoposide
CTD PMID:10327070 PMID:15228094 PMID:21712253 PMID:25866362 NCBI chr11:98,412,484...98,437,716
Ensembl chr11:98,412,470...98,437,716
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 affects response to substance
decreases expression
ISO ERBB3 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of ERBB3 mRNA
CTD PMID:15228094 PMID:16217747 PMID:29397400 NCBI chr10:128,567,523...128,589,635
Ensembl chr10:128,567,523...128,589,652
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 decreases expression ISO Etoposide results in decreased expression of ERBB4 mRNA CTD PMID:15228094 NCBI chr 1:68,031,884...69,108,576
Ensembl chr 1:68,032,186...69,108,059
JBrowse link
G Ereg epiregulin increases expression ISO Etoposide results in increased expression of EREG mRNA CTD PMID:15228094 NCBI chr 5:91,074,617...91,093,649
Ensembl chr 5:91,074,622...91,093,646
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO Etoposide inhibits the reaction [Estradiol results in increased activity of ESR1 protein] CTD PMID:30818834 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) increases response to substance
multiple interactions
ISO ESR2 protein results in increased susceptibility to Etoposide
TP53 protein inhibits the reaction [ESR2 protein results in increased susceptibility to Etoposide]
CTD PMID:20623183 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Esrp1 epithelial splicing regulatory protein 1 affects response to substance ISO ESRP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:11,331,933...11,386,783
Ensembl chr 4:11,331,933...11,386,783
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions ISO Etoposide inhibits the reaction [XCT790 results in decreased activity of ESRRA protein]; Etoposide promotes the reaction [PPARGC1A protein results in increased activity of ESRRA protein] CTD PMID:30818834 NCBI chr19:6,910,977...6,922,048
Ensembl chr19:6,910,977...6,921,813
Ensembl chr19:6,910,977...6,921,813
JBrowse link
G Etv6 ets variant 6 increases response to substance
increases mutagenesis
ISO ETV6 gene mutant form results in increased susceptibility to Etoposide
Etoposide results in increased mutagenesis of ETV6 gene
CTD PMID:15217836 PMID:28624474 NCBI chr 6:134,035,700...134,270,158
Ensembl chr 6:134,035,700...134,270,158
JBrowse link
G Exoc4 exocyst complex component 4 increases expression EXP Etoposide results in increased expression of EXOC4 mRNA CTD PMID:25270620 NCBI chr 6:33,249,090...33,973,979
Ensembl chr 6:33,249,085...33,973,979
JBrowse link
G F11r F11 receptor increases expression ISO Etoposide results in increased expression of F11R mRNA CTD PMID:29397400 NCBI chr 1:171,437,561...171,464,593
Ensembl chr 1:171,437,535...171,464,603
JBrowse link
G F2r coagulation factor II (thrombin) receptor affects response to substance ISO F2R protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:95,601,780...95,618,466
Ensembl chr13:95,601,803...95,618,487
JBrowse link
G F3 coagulation factor III increases expression ISO Etoposide results in increased expression of F3 mRNA CTD PMID:12542493 NCBI chr 3:121,723,537...121,735,052
Ensembl chr 3:121,723,537...121,735,048
JBrowse link
G Fads3 fatty acid desaturase 3 increases expression ISO Etoposide results in increased expression of FADS3 mRNA CTD PMID:21527772 NCBI chr19:10,040,855...10,060,113
Ensembl chr19:10,041,569...10,060,110
JBrowse link
G Fam171a1 family with sequence similarity 171, member A1 affects response to substance ISO FAM171A1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:3,114,224...3,227,806
Ensembl chr 2:3,114,224...3,227,806
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions
increases expression
ISO
EXP
3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein]; Etoposide results in increased expression of and affects the localization of FAS protein; Lithium inhibits the reaction [Etoposide results in increased expression of and affects the localization of FAS protein]
Etoposide results in increased expression of FAS mRNA
Etoposide results in increased expression of FAS mRNA; Etoposide results in increased expression of FAS protein
CTD PMID:12513834 PMID:15475000 PMID:16192531 PMID:29397400 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions
increases expression
increases activity
ISO
EXP
[linsidomine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [spermine nitric oxide complex results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; Nitric Oxide inhibits the reaction [Etoposide results in increased activity of FASLG promoter]
Etoposide results in increased expression of FASL mRNA
CTD PMID:10811113 PMID:12513834 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fasn fatty acid synthase increases expression ISO Etoposide results in increased expression of FASN mRNA CTD PMID:17089011 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fbl fibrillarin affects localization ISO Etoposide analog affects the localization of FBL protein CTD PMID:10942594 NCBI chr 7:28,168,893...28,179,269
Ensembl chr 7:28,169,710...28,179,269
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects response to substance ISO FDFT1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:63,145,150...63,181,687
Ensembl chr14:63,145,150...63,179,578
JBrowse link
G Fdxr ferredoxin reductase increases expression ISO Etoposide results in increased expression of FDXR mRNA CTD PMID:17374387 NCBI chr11:115,268,024...115,277,101
Ensembl chr11:115,268,024...115,277,050
JBrowse link
G Fgf2 fibroblast growth factor 2 affects response to substance ISO FGF2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Fhl1 four and a half LIM domains 1 affects response to substance ISO FHL1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:56,731,209...56,793,346
Ensembl chr  X:56,731,787...56,793,346
JBrowse link
G Fhl2 four and a half LIM domains 2 decreases expression ISO Etoposide results in decreased expression of FHL2 mRNA CTD PMID:29397400 NCBI chr 1:43,123,071...43,198,343
Ensembl chr 1:43,123,074...43,196,984
JBrowse link
G Flnc filamin C, gamma increases expression ISO Etoposide results in increased expression of FLNC mRNA CTD PMID:21527772 NCBI chr 6:29,433,153...29,461,889
Ensembl chr 6:29,433,256...29,461,883
JBrowse link
G Fos FBJ osteosarcoma oncogene decreases response to substance
increases expression
multiple interactions
ISO FOS protein results in decreased susceptibility to Etoposide
Etoposide results in increased expression of FOS
[Etoposide co-treated with Cyclic AMP] results in increased expression of FOS mRNA; Acetylcysteine inhibits the reaction [Etoposide results in increased expression of FOS]
CTD PMID:10711420 PMID:18314485 PMID:23824011 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosl1 fos-like antigen 1 increases expression EXP Etoposide results in increased expression of FOSL1 mRNA CTD PMID:25270620 NCBI chr19:5,447,698...5,455,938
Ensembl chr19:5,447,547...5,455,946
JBrowse link
G Foxf2 forkhead box F2 affects response to substance ISO FOXF2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:31,625,816...31,631,406
Ensembl chr13:31,625,816...31,631,403
JBrowse link
G Foxj2 forkhead box J2 decreases expression ISO Etoposide results in decreased expression of FOXJ2 mRNA CTD PMID:24211769 NCBI chr 6:122,820,184...122,845,366
Ensembl chr 6:122,819,914...122,845,366
JBrowse link
G Foxo1 forkhead box O1 increases phosphorylation
multiple interactions
ISO Etoposide results in increased phosphorylation of FOXO1 protein
wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]
CTD PMID:17935137 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Foxo3 forkhead box O3 increases phosphorylation
increases response to substance
multiple interactions
ISO Etoposide results in increased phosphorylation of FOXO3 protein
FOXO3 protein results in increased susceptibility to Etoposide
[FOXO3 protein results in decreased expression of BIRC5 protein] which results in increased susceptibility to Etoposide; BIRC5 protein inhibits the reaction [FOXO3 protein results in increased susceptibility to Etoposide]; wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]
CTD PMID:17935137 PMID:19211844 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Fth1 ferritin heavy polypeptide 1 multiple interactions
increases expression
EXP HIPK2 protein promotes the reaction [Etoposide results in increased expression of FTH1 mRNA] CTD PMID:20980392 NCBI chr19:9,980,600...9,985,111
Ensembl chr19:9,980,598...9,985,098
JBrowse link
G Fut8 fucosyltransferase 8 affects response to substance ISO FUT8 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr12:77,237,430...77,475,998
Ensembl chr12:77,238,125...77,476,338
JBrowse link
G Fyn Fyn proto-oncogene affects response to substance
decreases expression
ISO
EXP
FYN protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of FYN mRNA
CTD PMID:16217747 PMID:25270620 NCBI chr10:39,369,743...39,565,381
Ensembl chr10:39,368,855...39,565,381
JBrowse link
G Fzd1 frizzled class receptor 1 decreases expression ISO Etoposide results in decreased expression of FZD1 mRNA CTD PMID:24211769 NCBI chr 5:4,753,839...4,758,216
Ensembl chr 5:4,753,839...4,758,035
JBrowse link
G Fzd5 frizzled class receptor 5 decreases expression EXP Etoposide results in decreased expression of FZD5 mRNA CTD PMID:25270620 NCBI chr 1:64,730,558...64,737,750
Ensembl chr 1:64,730,558...64,737,751
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha increases response to substance
increases expression
ISO GADD45A protein results in increased susceptibility to Etoposide
Etoposide results in increased expression of GADD45A mRNA
CTD PMID:19003803 PMID:21527772 PMID:29397400 PMID:31542801 NCBI chr 6:67,035,096...67,037,407
Ensembl chr 6:67,035,096...67,037,457
JBrowse link
G Ganab alpha glucosidase 2 alpha neutral subunit multiple interactions
decreases expression
EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of GANAB protein
Etoposide results in decreased expression of GANAB protein
CTD PMID:29733421 NCBI chr19:8,898,057...8,916,742
Ensembl chr19:8,898,071...8,916,672
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Etoposide results in increased expression of GAPDH protein CTD PMID:29733421 NCBI chr 6:125,161,852...125,166,467
Ensembl chr 6:125,161,715...125,166,467
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide CTD PMID:10900222 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit multiple interactions ISO [GCLC protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; [GCLC protein co-treated with GCLM protein] results in decreased susceptibility to Etoposide CTD PMID:10900222 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732
JBrowse link
G Gdf15 growth differentiation factor 15 multiple interactions
increases expression
ISO Etoposide promotes the reaction [[TP53 protein binds to GDF15 promoter] which results in increased expression of GDF15 mRNA]
[Etoposide results in increased expression of TP53 protein] which results in increased expression of GDF15 protein; Etoposide results in increased expression of GDF15 mRNA; Etoposide results in increased expression of GDF15 protein
CTD PMID:11895857 PMID:16120219 PMID:24211769 PMID:29397400 NCBI chr 8:70,629,393...70,632,470
Ensembl chr 8:70,629,393...70,632,456
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases response to substance
EXP GJA1 protein affects the reaction [Simvastatin results in increased susceptibility to Etoposide]; Tetradecanoylphorbol Acetate affects the reaction [GJA1 protein results in increased susceptibility to Etoposide] CTD PMID:23978459 NCBI chr10:56,377,300...56,390,419
Ensembl chr10:56,377,330...56,402,513
JBrowse link
G Gja5 gap junction protein, alpha 5 decreases expression ISO Etoposide results in decreased expression of GJA5 mRNA CTD PMID:29397400 NCBI chr 3:97,032,402...97,053,634
Ensembl chr 3:96,904,693...97,077,416
JBrowse link
G Gls2 glutaminase 2 (liver, mitochondrial) increases expression ISO Etoposide results in increased expression of GLS2 mRNA CTD PMID:21527772 PMID:29397400 NCBI chr10:128,194,635...128,210,004
Ensembl chr10:128,194,457...128,210,004
JBrowse link
G Gm20348 predicted gene, 20348 increases expression ISO Etoposide results in increased expression of TP53I3 mRNA CTD PMID:17374387 NCBI chr12:4,810,475...4,817,155 JBrowse link
G Gm40318 predicted gene, 40318 increases response to substance
affects response to substance
ISO S100P protein results in increased susceptibility to Etoposide
S100P protein affects the susceptibility to Etoposide
CTD PMID:16217747 PMID:18636193 NCBI chr 5:36,762,504...36,767,419
Ensembl chr 5:36,762,617...36,766,695
JBrowse link
G Gpihbp1 GPI-anchored HDL-binding protein 1 decreases expression EXP Etoposide results in decreased expression of GPIHBP1 mRNA CTD PMID:25270620 NCBI chr15:75,596,630...75,598,213
Ensembl chr15:75,596,628...75,599,481
JBrowse link
G Gpm6b glycoprotein m6b affects response to substance ISO GPM6B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:166,238,943...166,389,033
Ensembl chr  X:166,238,911...166,388,988
JBrowse link
G Gpnmb glycoprotein (transmembrane) nmb increases expression ISO Etoposide results in increased expression of GPNMB mRNA CTD PMID:29397400 NCBI chr 6:49,036,518...49,058,182
Ensembl chr 6:49,036,546...49,070,929
JBrowse link
G Gpr37 G protein-coupled receptor 37 affects response to substance ISO GPR37 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:25,668,523...25,689,980
Ensembl chr 6:25,665,878...25,690,729
JBrowse link
G Gpsm2 G-protein signalling modulator 2 (AGS3-like, C. elegans) affects response to substance ISO GPSM2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:108,678,270...108,722,331
Ensembl chr 3:108,678,638...108,722,309
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Etoposide results in increased expression of GPX1 mRNA CTD PMID:29397400 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression EXP Etoposide results in increased expression of GPX3 mRNA CTD PMID:25270620 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Gria3 glutamate receptor, ionotropic, AMPA3 (alpha 3) increases expression EXP Etoposide results in increased expression of GRIA3 mRNA CTD PMID:25270620 NCBI chr  X:41,400,819...41,678,601
Ensembl chr  X:41,400,854...41,678,601
JBrowse link
G Grpel1 GrpE-like 1, mitochondrial decreases expression ISO Etoposide results in decreased expression of GRPEL1 mRNA CTD PMID:24211769 NCBI chr 5:36,465,185...36,474,077
Ensembl chr 5:36,464,998...36,474,080
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases activity
EXP BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]
[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein; Etoposide results in increased activity of GSK3B protein
CTD PMID:19408126 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gstm1 glutathione S-transferase, mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Etoposide CTD PMID:15713801 NCBI chr 3:108,012,250...108,017,973
Ensembl chr 3:108,012,255...108,017,973
JBrowse link
G Gstm4 glutathione S-transferase, mu 4 affects response to substance ISO GSTM4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:108,030,571...108,045,179
Ensembl chr 3:108,040,408...108,044,894
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 multiple interactions
decreases response to substance
affects response to substance
ISO Curcumin inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; Ethacrynic Acid inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to Etoposide]; Sulfinpyrazone inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]; verlukast inhibits the reaction [GSTP1 protein results in decreased susceptibility to Etoposide]
GSTP1 gene polymorphism affects the susceptibility to Etoposide
CTD PMID:10900222 PMID:12969965 PMID:15999103 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G H2-M2 histocompatibility 2, M region locus 2 affects expression ISO Etoposide affects the expression of HLA-B mRNA CTD PMID:25811541 NCBI chr17:37,480,851...37,483,554
Ensembl chr17:37,480,851...37,483,552
JBrowse link
G H2-Q1 histocompatibility 2, Q region locus 1 affects expression ISO Etoposide affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr17:35,320,525...35,328,142
Ensembl chr17:35,320,405...35,325,099
JBrowse link
G H2-T23 histocompatibility 2, T region locus 23 affects expression ISO Etoposide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr17:36,029,977...36,032,701
Ensembl chr17:36,029,773...36,032,855
JBrowse link
G H2ax H2A.X variant histone multiple interactions
decreases response to substance
increases expression
increases phosphorylation
ISO
EXP
Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]; nimesulide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein]; palbociclib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; pifithrin promotes the reaction [Etoposide results in increased expression of H2AX protein]
H2AX protein results in decreased susceptibility to Etoposide
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide results in increased expression of H2AX protein]; TOP2B protein affects the reaction [Etoposide results in increased expression of H2AX protein]
4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione inhibits the reaction [Etoposide results in increased expression of H2AX protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Etoposide results in increased expression of H2AX protein]; Bortezomib inhibits the reaction [Etoposide results in increased expression of H2AX protein]; Razoxane inhibits the reaction [Etoposide results in increased expression of H2AX protein]
CTD PMID:17875725 PMID:20643100 PMID:20978201 PMID:21555580 PMID:21745461 More... NCBI chr 9:44,334,715...44,336,077
Ensembl chr 9:44,334,694...44,336,077
JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Etoposide results in decreased expression of HAL mRNA CTD PMID:25270620 NCBI chr10:93,488,768...93,516,761
Ensembl chr10:93,488,768...93,519,304
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression
multiple interactions
EXP
ISO
Etoposide results in decreased expression of HAMP mRNA
Etoposide inhibits the reaction [BMP6 protein results in increased expression of HAMP mRNA]
CTD PMID:25270620 PMID:25633564 NCBI chr 7:30,942,368...30,944,029
Ensembl chr 7:30,942,368...30,944,032
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Etoposide results in increased expression of HBEGF mRNA CTD PMID:15228094 NCBI chr18:36,504,927...36,515,805
Ensembl chr18:36,504,927...36,515,805
JBrowse link
G Hbp1 high mobility group box transcription factor 1 decreases expression ISO Etoposide results in decreased expression of HBP1 mRNA CTD PMID:24211769 NCBI chr12:31,926,452...31,950,530
Ensembl chr12:31,926,254...31,950,535
JBrowse link
G Hdac4 histone deacetylase 4 affects response to substance ISO HDAC4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:91,928,779...92,195,702
Ensembl chr 1:91,928,779...92,195,699
JBrowse link
G Heph hephaestin affects response to substance ISO HEPH protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:96,455,436...96,574,485
Ensembl chr  X:96,455,359...96,574,485
JBrowse link
G Hic1 hypermethylated in cancer 1 multiple interactions
increases expression
ISO E2F1 protein affects the reaction [Etoposide results in increased expression of HIC1 mRNA]; Etoposide promotes the reaction [E2F1 protein binds to HIC1 promoter] CTD PMID:19491197 NCBI chr11:75,161,377...75,170,255
Ensembl chr11:75,164,565...75,169,519
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO HIF1A mutant form inhibits the reaction [Oxygen deficiency results in decreased susceptibility to Etoposide] CTD PMID:23144690 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 increases activity
multiple interactions
decreases response to substance
ISO
EXP
Etoposide results in increased activity of HIPK2 protein
HIPK2 gene mutant form inhibits the reaction [Etoposide results in increased expression of and results in increased phosphorylation of CREB1 protein]; HIPK2 gene mutant form promotes the reaction [Etoposide results in increased activity of CASP3 protein]; HIPK2 protein promotes the reaction [Etoposide results in increased expression of FTH1 mRNA]; HIPK2 protein promotes the reaction [Etoposide results in increased expression of NQO1 mRNA]
HIPK2 results in decreased susceptibility to Etoposide
HIPK2 mutant form inhibits the reaction [Etoposide results in increased expression of BDNF mRNA]
CTD PMID:20573984 PMID:20980392 NCBI chr 6:38,687,512...38,876,331
Ensembl chr 6:38,694,390...38,876,165
JBrowse link
G Hmces 5-hydroxymethylcytosine (hmC) binding, ES cell specific decreases expression EXP Etoposide results in decreased expression of HMCES mRNA CTD PMID:25270620 NCBI chr 6:87,913,907...87,936,619
Ensembl chr 6:87,913,935...87,936,629
JBrowse link
G Hmg20b high mobility group 20B affects response to substance ISO HMG20B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:81,346,046...81,350,943
Ensembl chr10:81,346,048...81,350,480
JBrowse link
G Hmga2 high mobility group AT-hook 2 affects response to substance ISO HMGA2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:120,361,268...120,476,469
Ensembl chr10:120,361,275...120,476,469
JBrowse link
G Hmgb1 high mobility group box 1 decreases response to substance
increases secretion
ISO HMGB1 protein results in decreased susceptibility to Etoposide
Etoposide results in increased secretion of HMGB1 protein
CTD PMID:27807322 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hnrnph2 heterogeneous nuclear ribonucleoprotein H2 decreases expression EXP Etoposide results in decreased expression of HNRNPH2 protein CTD PMID:29733421 NCBI chr  X:134,601,179...134,607,060
Ensembl chr  X:134,601,179...134,607,060
JBrowse link
G Hoxa5 homeobox A5 affects response to substance ISO HOXA5 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:52,201,754...52,204,587
Ensembl chr 6:52,201,754...52,204,587
JBrowse link
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 multiple interactions ISO [Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90AA1 protein CTD PMID:24478030 NCBI chr12:110,691,036...110,696,395
Ensembl chr12:110,690,605...110,702,728
JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 multiple interactions ISO [Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of HSP90B1 protein CTD PMID:24478030 NCBI chr10:86,690,841...86,705,444
Ensembl chr10:86,690,209...86,705,509
JBrowse link
G Hspa2 heat shock protein 2 affects response to substance ISO HSPA2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr12:76,403,812...76,406,938
Ensembl chr12:76,404,176...76,406,938
JBrowse link
G Hspe1 heat shock protein 1 (chaperonin 10) increases expression EXP Etoposide results in increased expression of HSPE1 protein CTD PMID:29733421 NCBI chr 1:55,088,148...55,091,317
Ensembl chr 1:55,088,132...55,091,307
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 affects response to substance
increases response to substance
multiple interactions
ISO
EXP
HTATIP2 protein affects the susceptibility to Etoposide
HTATIP2 protein results in increased susceptibility to Etoposide
HTATIP2 protein promotes the reaction [Etoposide results in increased activity of CASP9 protein]; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of PARP1 protein]
CTD PMID:16217747 PMID:16799960 NCBI chr 7:49,759,045...49,774,000
Ensembl chr 7:49,759,115...49,773,975
JBrowse link
G Htr4 5 hydroxytryptamine (serotonin) receptor 4 affects response to substance ISO HTR4 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:62,323,546...62,503,027
Ensembl chr18:62,324,204...62,496,577
JBrowse link
G Ier5 immediate early response 5 increases expression ISO Etoposide results in increased expression of IER5 mRNA CTD PMID:21527772 NCBI chr 1:155,096,367...155,099,636
Ensembl chr 1:155,096,361...155,099,636
JBrowse link
G Ifitm1 interferon induced transmembrane protein 1 affects response to substance ISO IFITM1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:140,967,429...140,969,827
Ensembl chr 7:140,967,221...140,969,825
JBrowse link
G Igdcc4 immunoglobulin superfamily, DCC subclass, member 4 increases expression EXP Etoposide results in increased expression of IGDCC4 mRNA CTD PMID:25270620 NCBI chr 9:65,101,023...65,137,947
Ensembl chr 9:65,101,486...65,137,940
JBrowse link
G Igf1r insulin-like growth factor I receptor affects response to substance ISO IGF1R protein affects the susceptibility to Etoposide CTD PMID:15499378 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 affects response to substance ISO IGFBP7 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:77,349,240...77,408,045
Ensembl chr 5:77,349,240...77,408,041
JBrowse link
G Igsf11 immunoglobulin superfamily, member 11 decreases expression EXP Etoposide results in decreased expression of IGSF11 mRNA CTD PMID:25270620 NCBI chr16:38,892,476...39,027,159
Ensembl chr16:38,892,671...39,027,159
JBrowse link
G Ikbkb inhibitor of kappaB kinase beta affects response to substance EXP IKBKB protein affects the susceptibility to Etoposide CTD PMID:20159942 NCBI chr 8:22,659,205...22,706,589
Ensembl chr 8:22,659,212...22,706,589
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Etoposide results in increased expression of IL1B mRNA CTD PMID:18523641 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il4 interleukin 4 decreases response to substance
multiple interactions
ISO IL4 protein results in decreased susceptibility to Etoposide
[IL4 protein co-treated with VCAM1 protein] inhibits the reaction [Etoposide results in decreased folding of BAX protein]; [VCAM1 protein co-treated with IL4 protein] inhibits the reaction [Etoposide inhibits the reaction [BAX protein binds to BCL2L1 protein]]; [VCAM1 protein co-treated with IL4 protein] results in decreased susceptibility to Etoposide
CTD PMID:10620629 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
increases secretion
EXP
ISO
(4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine inhibits the reaction [Etoposide results in increased expression of IL6 mRNA]; (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine inhibits the reaction [Etoposide results in increased secretion of IL6 protein]
Etoposide results in increased expression of IL6 mRNA; Etoposide results in increased expression of IL6 protein
CTD PMID:15135310 PMID:17003255 PMID:18523641 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Inka2 inka box actin regulator 2 increases expression EXP Etoposide results in increased expression of INKA2 mRNA CTD PMID:25270620 NCBI chr 3:105,704,599...105,720,842
Ensembl chr 3:105,704,599...105,720,842
JBrowse link
G Insig1 insulin induced gene 1 affects response to substance ISO INSIG1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:28,071,412...28,078,662
Ensembl chr 5:28,071,363...28,078,662
JBrowse link
G Irs2 insulin receptor substrate 2 affects response to substance ISO IRS2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:10,984,681...11,008,929
Ensembl chr 8:10,984,681...11,008,458
JBrowse link
G Irx4 Iroquois homeobox 4 decreases expression ISO Etoposide results in decreased expression of IRX4 mRNA CTD PMID:29397400 NCBI chr13:73,259,589...73,269,622
Ensembl chr13:73,260,479...73,269,608
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression ISO Etoposide results in increased expression of ISG15 mRNA CTD PMID:21527772 NCBI chr 4:156,199,424...156,200,818
Ensembl chr 4:156,199,455...156,200,796
JBrowse link
G Isg20 interferon-stimulated protein affects response to substance ISO ISG20 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:78,913,396...78,920,396
Ensembl chr 7:78,913,424...78,920,396
JBrowse link
G Isg20l2 interferon stimulated exonuclease gene 20-like 2 decreases expression ISO Etoposide results in decreased expression of ISG20L2 mRNA CTD PMID:24211769 NCBI chr 3:87,930,314...87,940,686
Ensembl chr 3:87,930,314...87,940,686
JBrowse link
G Itga2b integrin alpha 2b increases expression ISO Etoposide results in increased expression of ITGA2B mRNA CTD PMID:21527772 NCBI chr11:102,453,297...102,469,883
Ensembl chr11:102,453,297...102,470,122
JBrowse link
G Itgb3 integrin beta 3 increases response to substance ISO ITGB3 protein results in increased susceptibility to Etoposide CTD PMID:21332719 NCBI chr11:104,608,000...104,670,476
Ensembl chr11:104,608,000...104,670,476
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 affects response to substance ISO ITPR1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:108,213,083...108,551,116
Ensembl chr 6:108,213,096...108,551,109
JBrowse link
G Jun jun proto-oncogene multiple interactions ISO [Etoposide co-treated with Cyclic AMP] results in increased expression of JUN mRNA CTD PMID:10711420 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 affects response to substance ISO KCNAB2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:152,390,744...152,477,549
Ensembl chr 4:152,390,742...152,477,910
JBrowse link
G Kcne3 potassium voltage-gated channel, Isk-related subfamily, gene 3 decreases expression EXP Etoposide results in decreased expression of KCNE3 mRNA CTD PMID:25270620 NCBI chr 7:100,176,507...100,184,869
Ensembl chr 7:100,176,502...100,184,869
JBrowse link
G Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 decreases expression ISO Etoposide results in decreased expression of KCNN2 mRNA CTD PMID:29397400 NCBI chr18:45,268,750...45,685,887
Ensembl chr18:45,268,860...45,686,024
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 decreases response to substance
multiple interactions
increases response to substance
ISO KEAP1 protein results in decreased susceptibility to Etoposide
KEAP1 protein affects the reaction [Etoposide results in increased expression of CDKN1A protein]
KEAP1 mRNA results in increased susceptibility to Etoposide
CTD PMID:22684020 PMID:26708503 PMID:27982581 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361
JBrowse link
G Kif1a kinesin family member 1A increases expression ISO Etoposide results in increased expression of KIF1A mRNA CTD PMID:21527772 NCBI chr 1:93,015,455...93,102,039
Ensembl chr 1:93,015,464...93,101,951
JBrowse link
G Kif20a kinesin family member 20A decreases expression ISO Etoposide results in decreased expression of KIF20A mRNA CTD PMID:24211769 NCBI chr18:34,624,624...34,633,277
Ensembl chr18:34,624,613...34,633,277
JBrowse link
G Kif23 kinesin family member 23 decreases expression EXP Etoposide results in decreased expression of KIF23 mRNA CTD PMID:25270620 NCBI chr 9:61,917,277...61,946,810
Ensembl chr 9:61,915,905...61,946,774
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression
multiple interactions
EXP Etoposide results in increased expression of KIT protein
[Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in increased expression of KIT protein
CTD PMID:29733421 NCBI chr 5:75,574,987...75,656,722
Ensembl chr 5:75,574,916...75,656,722
JBrowse link
G Klf5 Kruppel-like factor 5 increases expression ISO Etoposide results in increased expression of KLF5 mRNA CTD PMID:29397400 NCBI chr14:99,298,691...99,313,412
Ensembl chr14:99,298,691...99,315,036
JBrowse link
G Klf6 Kruppel-like factor 6 decreases expression ISO Etoposide results in decreased expression of KLF6 mRNA CTD PMID:24211769 NCBI chr13:5,861,489...5,870,393
Ensembl chr13:5,861,482...5,870,394
JBrowse link
G Klhl26 kelch-like 26 increases expression EXP Etoposide results in increased expression of KLHL26 mRNA CTD PMID:25270620 NCBI chr 8:70,450,218...70,476,989
Ensembl chr 8:70,450,219...70,476,968
JBrowse link
G Kmt2a lysine (K)-specific methyltransferase 2A increases response to substance
increases mutagenesis
increases cleavage
ISO KMT2A gene mutant form results in increased susceptibility to Etoposide
Etoposide results in increased mutagenesis of KMT2A gene
Etoposide results in increased cleavage of KMT2A gene
CTD PMID:14712291 PMID:24086652 PMID:28624474 NCBI chr 9:44,803,355...44,881,352
Ensembl chr 9:44,803,355...44,881,296
JBrowse link
G Krt19 keratin 19 increases expression ISO Etoposide results in increased expression of KRT19 mRNA CTD PMID:29397400 NCBI chr11:100,140,810...100,145,926
Ensembl chr11:100,140,810...100,148,665
JBrowse link
G Krt80 keratin 80 increases expression ISO Etoposide results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr15:101,348,315...101,370,162
Ensembl chr15:101,347,444...101,370,162
JBrowse link
G Kynu kynureninase affects response to substance ISO KYNU protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:43,555,258...43,683,048
Ensembl chr 2:43,555,329...43,682,715
JBrowse link
G Lancl1 LanC (bacterial lantibiotic synthetase component C)-like 1 affects response to substance ISO LANCL1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:67,000,517...67,038,891
Ensembl chr 1:67,000,517...67,038,872
JBrowse link
G Lap3 leucine aminopeptidase 3 decreases expression EXP Etoposide results in decreased expression of LAP3 mRNA CTD PMID:25270620 NCBI chr 5:45,493,374...45,512,691
Ensembl chr 5:45,493,374...45,512,691
JBrowse link
G Lcn2 lipocalin 2 increases response to substance ISO LCN2 protein results in increased susceptibility to Etoposide CTD PMID:19860839 NCBI chr 2:32,384,637...32,387,739
Ensembl chr 2:32,384,633...32,388,252
JBrowse link
G Ldb3 LIM domain binding 3 decreases expression ISO Etoposide results in decreased expression of LDB3 mRNA CTD PMID:29397400 NCBI chr14:34,526,699...34,590,314
Ensembl chr14:34,526,603...34,588,682
JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 affects response to substance ISO LGALS3 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:47,373,860...47,386,167
Ensembl chr14:47,367,751...47,386,160
JBrowse link
G Lgals7 lectin, galactose binding, soluble 7 increases expression ISO Etoposide results in increased expression of LGALS7 mRNA CTD PMID:21527772 NCBI chr 7:28,863,796...28,866,285
Ensembl chr 7:28,863,853...28,866,284
JBrowse link
G Lhx1 LIM homeobox protein 1 multiple interactions
decreases expression
EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of LHX1 mRNA
Etoposide results in decreased expression of LHX1 mRNA
CTD PMID:29733421 NCBI chr11:84,517,975...84,525,534
Ensembl chr11:84,518,284...84,525,535
JBrowse link
G Lhx2 LIM homeobox protein 2 decreases expression ISO Etoposide results in decreased expression of LHX2 mRNA CTD PMID:24211769 NCBI chr 2:38,339,271...38,369,737
Ensembl chr 2:38,339,281...38,369,733
JBrowse link
G Lif leukemia inhibitory factor increases expression ISO Etoposide results in increased expression of LIF mRNA CTD PMID:29397400 NCBI chr11:4,257,568...4,272,514
Ensembl chr11:4,257,557...4,272,514
JBrowse link
G Limch1 LIM and calponin homology domains 1 affects response to substance ISO LIMCH1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 5:66,745,889...67,057,159
Ensembl chr 5:66,745,827...67,057,158
JBrowse link
G Lipa lysosomal acid lipase A affects response to substance ISO LIPA protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:34,492,316...34,527,474
Ensembl chr19:34,492,318...34,527,474
JBrowse link
G Lrrc47 leucine rich repeat containing 47 decreases expression ISO Etoposide results in decreased expression of LRRC47 mRNA CTD PMID:24211769 NCBI chr 4:154,011,803...154,021,512
Ensembl chr 4:154,011,731...154,021,513
JBrowse link
G Ltbr lymphotoxin B receptor multiple interactions
increases expression
ISO Estradiol inhibits the reaction [Etoposide results in increased expression of LTBR mRNA] CTD PMID:19426747 NCBI chr 6:125,306,571...125,313,885
Ensembl chr 6:125,306,571...125,313,885
JBrowse link
G Lxn latexin increases response to substance EXP LXN protein results in increased susceptibility to Etoposide CTD PMID:25341047 NCBI chr 3:67,457,999...67,463,907
Ensembl chr 3:67,457,998...67,463,926
JBrowse link
G Ly6e lymphocyte antigen 6 complex, locus E affects response to substance ISO LY6E protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:74,955,025...74,959,904
Ensembl chr15:74,955,051...74,959,905
JBrowse link
G Lyz1 lysozyme 1 decreases expression EXP Etoposide results in decreased expression of LYZ1 mRNA CTD PMID:25270620 NCBI chr10:117,287,795...117,292,868
Ensembl chr10:117,287,797...117,292,868
JBrowse link
G Macf1 microtubule-actin crosslinking factor 1 affects response to substance ISO MACF1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:123,349,633...123,687,802
Ensembl chr 4:123,349,633...123,684,360
JBrowse link
G Magea6 MAGE family member A6 affects response to substance ISO MAGEA6 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:154,923,895...154,936,074
Ensembl chr  X:154,924,012...154,935,987
JBrowse link
G Man2b1 mannosidase 2, alpha B1 increases expression EXP Etoposide results in increased expression of MAN2B1 mRNA CTD PMID:25270620 NCBI chr 8:85,082,730...85,098,739
Ensembl chr 8:85,083,270...85,098,282
JBrowse link
G Map2k3 mitogen-activated protein kinase kinase 3 increases expression ISO Etoposide results in increased expression of MAP2K3 mRNA CTD PMID:17374387 NCBI chr11:60,932,054...60,952,811
Ensembl chr11:60,932,033...60,952,811
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 decreases expression ISO Etoposide results in decreased expression of MAP3K5 mRNA CTD PMID:17374387 NCBI chr10:19,934,101...20,142,750
Ensembl chr10:19,934,472...20,142,753
JBrowse link
G Map7 microtubule-associated protein 7 affects response to substance ISO MAP7 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:20,148,920...20,281,590
Ensembl chr10:20,148,471...20,281,590
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
ISO 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Etoposide results in increased phosphorylation of MAPK1 protein] CTD PMID:16014620 PMID:19720055 PMID:26046675 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk12 mitogen-activated protein kinase 12 increases activity
affects response to substance
multiple interactions
ISO Etoposide results in increased activity of MAPK12 protein
MAPK12 protein affects the susceptibility to Etoposide
[MAPK12 protein results in increased phosphorylation of TOP2A protein] which results in increased susceptibility to Etoposide; [MAPK12 protein results in increased stability of TOP2A protein] which results in increased susceptibility to Etoposide
CTD PMID:21878638 NCBI chr15:89,130,584...89,141,577
Ensembl chr15:89,130,584...89,140,703
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
ISO 3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Etoposide results in increased phosphorylation of MAPK3 protein] CTD PMID:16014620 PMID:19720055 PMID:26046675 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 multiple interactions
increases phosphorylation
EXP (4-(5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl)pyridin-2-yl)-(1-phenylethyl)amine inhibits the reaction [Etoposide results in increased phosphorylation of MAPKAPK2 protein] CTD PMID:17003255 NCBI chr 1:131,053,700...131,097,871
Ensembl chr 1:131,053,700...131,097,826
JBrowse link
G Matn2 matrilin 2 affects response to substance ISO MATN2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr15:34,306,681...34,436,242
Ensembl chr15:34,306,677...34,436,273
JBrowse link
G Mbp myelin basic protein affects response to substance ISO MBP protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:82,475,091...82,585,637
Ensembl chr18:82,475,146...82,585,637
JBrowse link
G Mcam melanoma cell adhesion molecule increases expression EXP Etoposide results in increased expression of MCAM mRNA CTD PMID:25270620 NCBI chr 9:44,134,658...44,142,727
Ensembl chr 9:44,134,469...44,142,727
JBrowse link
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions
decreases expression
ISO wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein] CTD PMID:17935137 NCBI chr 3:95,656,944...95,663,179
Ensembl chr 3:95,658,788...95,663,176
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor decreases expression ISO Etoposide results in decreased expression of MCM10 mRNA CTD PMID:24211769 NCBI chr 2:4,990,724...5,012,791
Ensembl chr 2:4,989,714...5,012,791
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 decreases expression ISO Etoposide results in decreased expression of MCM2 mRNA CTD PMID:16120219 NCBI chr 6:88,883,474...88,898,780
Ensembl chr 6:88,883,474...88,898,780
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 decreases expression ISO Etoposide results in decreased expression of MCM6 mRNA CTD PMID:16120219 NCBI chr 1:128,331,575...128,359,705
Ensembl chr 1:128,331,590...128,359,664
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 decreases expression ISO Etoposide results in decreased expression of MCM7 mRNA CTD PMID:16120219 NCBI chr 5:138,164,583...138,172,111
Ensembl chr 5:138,164,583...138,172,422
JBrowse link
G Mcm8 minichromosome maintenance 8 homologous recombination repair factor decreases expression ISO Etoposide results in decreased expression of MCM8 mRNA CTD PMID:16120219 NCBI chr 2:132,816,137...132,844,197
Ensembl chr 2:132,816,141...132,844,197
JBrowse link
G Mdfic MyoD family inhibitor domain containing affects response to substance ISO MDFIC protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 6:15,720,566...15,802,169
Ensembl chr 6:15,720,661...15,802,169
JBrowse link
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of MDH2 protein CTD PMID:29733421 NCBI chr 5:135,778,649...135,790,386
Ensembl chr 5:135,778,480...135,790,398
JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 multiple interactions
decreases expression
increases phosphorylation
increases expression
decreases response to substance
ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]]; Cadmium Chloride affects the reaction [Etoposide results in increased phosphorylation of MDM2 protein]; Etoposide promotes the reaction [MDM2 protein binds to TOP2A protein]; wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein]
Etoposide results in decreased expression of MDM2 protein
Etoposide results in increased expression of MDM2 mRNA; Etoposide results in increased expression of MDM2 protein
Tetrachlorodibenzodioxin inhibits the reaction [Etoposide results in increased expression of MDM2 protein]
MDM2 promoter SNP results in decreased susceptibility to Etoposide
CTD PMID:15459018 PMID:16120219 PMID:17575151 PMID:17935137 PMID:18096571 More... NCBI chr10:117,688,875...117,710,758
Ensembl chr10:117,688,875...117,710,758
JBrowse link
G Me2 malic enzyme 2, NAD(+)-dependent, mitochondrial decreases expression EXP Etoposide results in decreased expression of ME2 protein CTD PMID:29733421 NCBI chr18:73,764,954...73,815,438
Ensembl chr18:73,769,903...73,815,449
JBrowse link
G Mir135b microRNA 135b increases expression ISO Etoposide results in increased expression of MIR135B mRNA CTD PMID:27570640 NCBI chr 1:132,198,088...132,198,184
Ensembl chr 1:132,198,088...132,198,184
JBrowse link
G Mir139 microRNA 139 increases expression ISO Etoposide results in increased expression of MIR139 mRNA CTD PMID:29397400 NCBI chr 7:101,475,376...101,475,443
Ensembl chr 7:101,475,376...101,475,443
JBrowse link
G Mir182 microRNA 182 increases expression ISO Etoposide results in increased expression of MIR182 mRNA CTD PMID:29397400 NCBI chr 6:30,165,918...30,165,992
Ensembl chr 6:30,165,918...30,165,992
JBrowse link
G Mir196b microRNA 196b increases expression ISO Etoposide results in increased expression of MIR196B mRNA CTD PMID:27570640 NCBI chr 6:52,230,081...52,230,165
Ensembl chr 6:52,230,081...52,230,165
JBrowse link
G Mir34c microRNA 34c increases expression ISO Etoposide results in increased expression of MIR34C mRNA CTD PMID:29397400 NCBI chr 9:51,103,034...51,103,110
Ensembl chr 9:51,103,034...51,103,110
JBrowse link
G Mir654 microRNA 654 increases response to substance ISO MIR654 mRNA results in increased susceptibility to Etoposide CTD PMID:20145152 NCBI chr12:109,723,218...109,723,301
Ensembl chr12:109,723,218...109,723,301
JBrowse link
G Mlana melan-A affects response to substance ISO MLANA protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:29,697,541...29,708,447
Ensembl chr19:29,697,824...29,708,634
JBrowse link
G Mllt11 myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 affects response to substance ISO MLLT11 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:95,218,544...95,229,632
Ensembl chr 3:95,219,135...95,232,171
JBrowse link
G Mmp1b matrix metallopeptidase 1b (interstitial collagenase) decreases expression
multiple interactions
ISO Etoposide results in decreased expression of MMP1 protein
pifithrin inhibits the reaction [Etoposide results in decreased expression of MMP1 protein]
CTD PMID:18557930 NCBI chr 9:7,367,670...7,388,026
Ensembl chr 9:7,368,239...7,388,047
JBrowse link
G Mocos molybdenum cofactor sulfurase affects response to substance ISO MOCOS protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr18:24,653,492...24,701,577
Ensembl chr18:24,653,691...24,701,575
JBrowse link
G Mpo myeloperoxidase increases metabolic processing ISO MPO protein results in increased metabolism of Etoposide CTD PMID:16841962 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413
JBrowse link
G Mpzl1 myelin protein zero-like 1 decreases expression ISO Etoposide results in decreased expression of MPZL1 mRNA CTD PMID:24211769 NCBI chr 1:165,592,176...165,634,541
Ensembl chr 1:165,592,240...165,634,538
JBrowse link
G Mr1 major histocompatibility complex, class I-related increases expression
affects expression
ISO Etoposide results in increased expression of MR1 mRNA
Etoposide affects the expression of MR1 mRNA
CTD PMID:21527772 PMID:25811541 NCBI chr 1:155,127,874...155,146,814
Ensembl chr 1:155,127,277...155,146,814
JBrowse link
G Mras muscle and microspikes RAS decreases expression EXP Etoposide results in decreased expression of MRAS mRNA CTD PMID:25270620 NCBI chr 9:99,385,420...99,437,700
Ensembl chr 9:99,385,420...99,437,381
JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression EXP Etoposide results in decreased expression of MRC1 mRNA CTD PMID:25270620 NCBI chr 2:14,229,414...14,332,023
Ensembl chr 2:14,229,392...14,332,057
JBrowse link
G Mrm2 mitochondrial rRNA methyltransferase 2 decreases expression ISO Etoposide results in decreased expression of MRM2 mRNA CTD PMID:24211769 NCBI chr 5:140,327,674...140,331,898
Ensembl chr 5:140,327,674...140,331,898
JBrowse link
G Msc musculin decreases expression EXP Etoposide results in decreased expression of MSC mRNA CTD PMID:25270620 NCBI chr 1:14,753,344...14,756,089
Ensembl chr 1:14,753,346...14,755,992
JBrowse link
G Msh6 mutS homolog 6 decreases expression ISO Etoposide results in decreased expression of MSH6 mRNA CTD PMID:24211769 NCBI chr17:87,975,050...87,990,892
Ensembl chr17:87,975,062...87,990,892
JBrowse link
G mt-Nd4 NADH dehydrogenase 4, mitochondrial increases expression ISO Etoposide results in increased expression of ND4 mRNA CTD PMID:26259609 NCBI chr MT:10,167...11,544
Ensembl chr MT:10,167...11,544
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase decreases expression EXP Etoposide results in decreased expression of MTHFD2 mRNA CTD PMID:25270620 NCBI chr 6:83,305,704...83,326,011
Ensembl chr 6:83,305,691...83,325,908
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation ISO Etoposide results in increased phosphorylation of MTOR protein CTD PMID:27769712 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Mtus1 mitochondrial tumor suppressor 1 affects response to substance ISO MTUS1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 8:40,990,912...41,133,983
Ensembl chr 8:40,990,914...41,133,726
JBrowse link
G Mxi1 MAX interactor 1, dimerization protein affects response to substance ISO MXI1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:53,310,128...53,373,293
Ensembl chr19:53,310,518...53,375,810
JBrowse link
G Myc myelocytomatosis oncogene decreases expression
increases response to substance
multiple interactions
ISO Etoposide results in decreased expression of MYC; Etoposide results in decreased expression of MYC mRNA
MYC protein results in increased susceptibility to Etoposide
MYC protein promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]
CTD PMID:9454737 PMID:21324178 PMID:21527772 NCBI chr15:61,985,341...61,990,361
Ensembl chr15:61,985,391...61,990,374
JBrowse link
G Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived multiple interactions
decreases response to substance
ISO [MYCN protein affects the expression of ABCC1 mRNA] which affects the susceptibility to Etoposide
MYCN protein results in decreased susceptibility to Etoposide
CTD PMID:10348353 NCBI chr12:12,936,093...12,941,836
Ensembl chr12:12,936,093...12,941,914
JBrowse link
G Myh7 myosin, heavy polypeptide 7, cardiac muscle, beta decreases expression ISO Etoposide results in decreased expression of MYH7 mRNA CTD PMID:29397400 NCBI chr14:54,970,684...54,994,626
Ensembl chr14:54,970,684...54,994,626
JBrowse link
G Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow decreases expression ISO Etoposide results in decreased expression of MYL2 mRNA CTD PMID:29397400 NCBI chr 5:122,092,724...122,113,473
Ensembl chr 5:122,100,951...122,113,472
JBrowse link
G Myl3 myosin, light polypeptide 3 decreases expression ISO Etoposide results in decreased expression of MYL3 mRNA CTD PMID:29397400 NCBI chr 9:110,763,678...110,769,802
Ensembl chr 9:110,741,861...110,769,798
JBrowse link
G Myom2 myomesin 2 decreases expression ISO Etoposide results in decreased expression of MYOM2 mRNA CTD PMID:29397400 NCBI chr 8:15,057,653...15,133,420
Ensembl chr 8:15,057,653...15,133,541
JBrowse link
G Myot myotilin increases expression ISO Etoposide results in increased expression of MYOT mRNA CTD PMID:29397400 NCBI chr18:44,334,053...44,355,740
Ensembl chr18:44,334,074...44,355,724
JBrowse link
G Myt1 myelin transcription factor 1 decreases expression ISO Etoposide results in decreased expression of MYT1 mRNA CTD PMID:16120219 NCBI chr 2:181,763,332...181,827,775
Ensembl chr 2:181,763,332...181,827,797
JBrowse link
G Nabp2 nucleic acid binding protein 2 multiple interactions
increases acetylation
ISO 4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid inhibits the reaction [Etoposide results in increased acetylation of NABP2 protein] CTD PMID:26170237 NCBI chr10:128,401,394...128,411,548
Ensembl chr10:128,401,395...128,411,492
JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 affects response to substance ISO NAP1L1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:111,472,882...111,498,150
Ensembl chr10:111,473,223...111,498,150
JBrowse link
G Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 decreases expression ISO Etoposide results in decreased expression of NCK2 mRNA CTD PMID:17374387 NCBI chr 1:43,445,483...43,570,518
Ensembl chr 1:43,444,579...43,570,515
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 decreases expression EXP Etoposide results in decreased expression of NECTIN2 mRNA CTD PMID:25270620 NCBI chr 7:19,716,644...19,749,573
Ensembl chr 7:19,716,644...19,750,483
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated gene 9 affects response to substance ISO NEDD9 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr13:41,309,916...41,487,362
Ensembl chr13:41,309,581...41,487,362
JBrowse link
G Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 decreases expression ISO Etoposide results in decreased expression of NEK2 mRNA CTD PMID:16120219 NCBI chr 1:191,821,449...191,833,049
Ensembl chr 1:191,821,444...191,833,050
JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases response to substance
multiple interactions
ISO NFE2L2 mRNA results in decreased susceptibility to Etoposide; NFE2L2 protein results in decreased susceptibility to Etoposide
NFE2L2 protein affects the reaction [Etoposide results in increased expression of SRXN1 protein]; NFE2L2 protein affects the reaction [Etoposide results in increased expression of TP53 protein]; trigonelline inhibits the reaction [NFE2L2 protein results in decreased susceptibility to Etoposide]
CTD PMID:26708503 PMID:27982581 PMID:33148531 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions
increases degradation
ISO wortmannin inhibits the reaction [Etoposide results in increased degradation of NFKBIA protein] CTD PMID:12637521 PMID:17935137 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Niban1 niban apoptosis regulator 1 affects response to substance ISO NIBAN1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:151,571,373...151,721,432
Ensembl chr 1:151,571,186...151,721,939
JBrowse link
G Nit2 nitrilase family, member 2 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of NIT2 protein CTD PMID:29733421 NCBI chr16:57,156,665...57,167,332
Ensembl chr16:57,156,665...57,167,341
JBrowse link
G Nmt2 N-myristoyltransferase 2 affects response to substance ISO NMT2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 2:3,284,212...3,328,877
Ensembl chr 2:3,284,212...3,328,877
JBrowse link
G Nos2 nitric oxide synthase 2, inducible increases expression ISO Etoposide results in increased expression of NOS2 mRNA
Etoposide results in increased expression of NOS2 protein
CTD PMID:15135310 PMID:26259609 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Npas1 neuronal PAS domain protein 1 increases expression ISO Etoposide results in increased expression of NPAS1 mRNA CTD PMID:21527772 NCBI chr 7:16,455,721...16,476,822
Ensembl chr 7:16,455,721...16,477,728
JBrowse link
G Npnt nephronectin increases expression EXP Etoposide results in increased expression of NPNT mRNA CTD PMID:25270620 NCBI chr 3:132,881,745...132,950,291
Ensembl chr 3:132,881,745...132,950,291
JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 affects response to substance
increases expression
multiple interactions
ISO
EXP
NQO1 protein affects the susceptibility to Etoposide
Etoposide results in increased expression of NQO1 mRNA
HIPK2 protein promotes the reaction [Etoposide results in increased expression of NQO1 mRNA]
CTD PMID:16217747 PMID:20980392 PMID:29397400 NCBI chr 8:107,388,225...107,403,205
Ensembl chr 8:107,388,225...107,403,206
JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 decreases expression EXP Etoposide results in decreased expression of NR0B1 mRNA CTD PMID:25270620 NCBI chr  X:86,191,775...86,195,947
Ensembl chr  X:86,191,764...86,195,947
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 affects localization
affects response to substance
multiple interactions
ISO Etoposide affects the localization of NR1H2 protein
NR1H2 protein affects the susceptibility to Etoposide
Etoposide promotes the reaction [NR1H2 protein results in increased expression of CETP mRNA]; NR1H2 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]
CTD PMID:25914138 NCBI chr 7:44,549,616...44,553,968
Ensembl chr 7:44,549,616...44,553,951
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 multiple interactions
affects response to substance
increases expression
ISO Etoposide promotes the reaction [NR1H3 protein results in increased expression of CETP mRNA]; Etoposide results in increased expression of and affects the localization of NR1H3 protein; NR1H3 mutant form inhibits the reaction [Etoposide results in increased expression of CETP mRNA]
NR1H3 protein affects the susceptibility to Etoposide
Etoposide results in increased expression of NR1H3 mRNA
CTD PMID:25914138 NCBI chr 2:91,184,061...91,202,829
Ensembl chr 2:91,184,061...91,202,834
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 affects response to substance
multiple interactions
increases activity
ISO NR1I2 protein affects the susceptibility to Etoposide
[Etoposide results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:17279585 PMID:25455453 NCBI chr16:38,248,349...38,294,849
Ensembl chr16:38,248,323...38,294,824
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Etoposide inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein] CTD PMID:30818834 NCBI chr 1:171,213,934...171,218,845
Ensembl chr 1:171,213,970...171,220,701
JBrowse link
G Nrap nebulin-related anchoring protein decreases expression ISO Etoposide results in decreased expression of NRAP mRNA CTD PMID:29397400 NCBI chr19:56,320,037...56,390,062
Ensembl chr19:56,320,035...56,390,037
JBrowse link
G Nrg1 neuregulin 1 increases expression ISO Etoposide results in increased expression of NRG1 mRNA CTD PMID:29397400 NCBI chr 8:31,807,452...32,891,609
Ensembl chr 8:31,814,551...32,884,797
JBrowse link
G Nrip1 nuclear receptor interacting protein 1 affects response to substance
decreases expression
ISO NRIP1 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of NRIP1 mRNA; Etoposide results in decreased expression of NRIP1 protein
CTD PMID:16217747 PMID:25914138 NCBI chr16:76,287,403...76,373,827
Ensembl chr16:76,287,400...76,373,827
JBrowse link
G Nupr1 nuclear protein transcription regulator 1 affects response to substance
decreases expression
ISO
EXP
NUPR1 protein affects the susceptibility to Etoposide
Etoposide results in decreased expression of NUPR1 mRNA
CTD PMID:16217747 PMID:25270620 NCBI chr 7:126,623,246...126,625,470
Ensembl chr 7:126,623,249...126,630,861
JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of OAT protein CTD PMID:29733421 NCBI chr 7:132,557,475...132,576,398
Ensembl chr 7:132,557,478...132,576,398
JBrowse link
G Oca2 oculocutaneous albinism II affects response to substance ISO OCA2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 7:56,239,593...56,536,518
Ensembl chr 7:56,239,760...56,536,518
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 decreases expression
multiple interactions
EXP Etoposide results in decreased expression of OGG1 mRNA
wogonin inhibits the reaction [Etoposide results in decreased expression of OGG1 mRNA]
CTD PMID:23872129 NCBI chr 6:113,326,972...113,334,877
Ensembl chr 6:113,326,972...113,335,068
JBrowse link
G P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 increases expression EXP Etoposide results in increased expression of P2RX7 mRNA CTD PMID:25270620 NCBI chr 5:122,643,927...122,692,336
Ensembl chr 5:122,643,911...122,691,432
JBrowse link
G Pabpc1 poly(A) binding protein, cytoplasmic 1 decreases expression EXP Etoposide results in decreased expression of PABPC1 protein CTD PMID:29733421 NCBI chr15:36,595,658...36,609,581
Ensembl chr15:36,595,661...36,609,668
JBrowse link
G Palb2 partner and localizer of BRCA2 decreases expression ISO Etoposide results in decreased expression of PALB2 mRNA CTD PMID:24211769 NCBI chr 7:122,107,262...122,132,980
Ensembl chr 7:122,107,262...122,132,985
JBrowse link
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 increases expression EXP Etoposide results in increased expression of PAPSS2 mRNA CTD PMID:25270620 NCBI chr19:32,595,669...32,667,187
Ensembl chr19:32,595,790...32,667,187
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage
multiple interactions
increases degradation
ISO Etoposide results in increased cleavage of PARP1 protein
3',4'-dihydroxyflavone analog inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; [CASP8 co-treated with TP53] affects the reaction [Etoposide results in increased cleavage of PARP1 protein]; [Colforsin co-treated with Theophylline] inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; [trigonelline co-treated with Etoposide] results in increased cleavage of PARP1 protein; BCL2 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; BCL2L1 protein inhibits the reaction [Etoposide results in increased degradation of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; CD40LG protein inhibits the reaction [Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; Etoposide promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; HTATIP2 protein promotes the reaction [Etoposide results in increased activity of PARP1 protein]; Nicotine inhibits the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein modified form promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]
Niacin deficiency affects the reaction [Etoposide results in increased cleavage of PARP1 protein]
CTD PMID:8840993 PMID:9454737 PMID:12690110 PMID:16014620 PMID:16545138 More... NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Pbk PDZ binding kinase affects response to substance ISO PBK protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr14:65,805,911...65,817,822
Ensembl chr14:65,805,837...65,817,822
JBrowse link
G Pcbp2 poly(rC) binding protein 2 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of PCBP2 protein CTD PMID:29733421 NCBI chr15:102,470,450...102,500,068
Ensembl chr15:102,470,539...102,500,061
JBrowse link
G Pcbp4 poly(rC) binding protein 4 decreases expression EXP Etoposide results in decreased expression of PCBP4 mRNA CTD PMID:25270620 NCBI chr 9:106,452,982...106,464,012
Ensembl chr 9:106,453,291...106,464,012
JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) decreases expression EXP Etoposide results in decreased expression of PCK2 mRNA CTD PMID:25270620 NCBI chr14:55,540,263...55,550,020
Ensembl chr14:55,540,266...55,551,242
JBrowse link
G Pde2a phosphodiesterase 2A, cGMP-stimulated decreases expression EXP Etoposide results in decreased expression of PDE2A mRNA CTD PMID:25270620 NCBI chr 7:101,421,691...101,512,829
Ensembl chr 7:101,410,886...101,512,819
Ensembl chr 7:101,410,886...101,512,819
JBrowse link
G Pde4b phosphodiesterase 4B, cAMP specific affects response to substance ISO PDE4B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 4:102,087,332...102,607,275
Ensembl chr 4:102,087,543...102,607,259
JBrowse link
G Pdgfc platelet-derived growth factor, C polypeptide affects response to substance ISO PDGFC protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:81,036,416...81,214,040
Ensembl chr 3:81,036,416...81,214,040
JBrowse link
G Pdia3 protein disulfide isomerase associated 3 multiple interactions ISO [Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein CTD PMID:24478030 NCBI chr 2:121,413,902...121,438,687
Ensembl chr 2:121,413,775...121,438,687
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase, isoenzyme 1 decreases expression ISO Etoposide results in decreased expression of PDK1 mRNA CTD PMID:29397400 NCBI chr 2:71,873,215...71,903,858
Ensembl chr 2:71,873,224...71,903,858
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase, isoenzyme 4 increases expression ISO Etoposide results in increased expression of PDK4 mRNA CTD PMID:29397400 NCBI chr 6:5,483,351...5,496,278
Ensembl chr 6:5,483,351...5,496,309
JBrowse link
G Pdlim3 PDZ and LIM domain 3 increases expression ISO Etoposide results in increased expression of PDLIM3 mRNA CTD PMID:29397400 NCBI chr 8:45,885,487...45,919,635
Ensembl chr 8:45,885,461...45,919,548
JBrowse link
G Pelo pelota mRNA surveillance and ribosome rescue factor decreases expression ISO Etoposide results in decreased expression of PELO mRNA CTD PMID:24211769 NCBI chr13:115,088,355...115,090,158
Ensembl chr13:115,088,355...115,090,186
JBrowse link
G Perp PERP, TP53 apoptosis effector increases expression EXP Etoposide results in increased expression of PERP mRNA CTD PMID:21382384 PMID:25270620 NCBI chr10:18,845,071...18,857,073
Ensembl chr10:18,845,020...18,857,073
JBrowse link
G Phgdh 3-phosphoglycerate dehydrogenase affects response to substance ISO PHGDH protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:98,313,171...98,339,969
Ensembl chr 3:98,313,170...98,339,990
JBrowse link
G Phlda3 pleckstrin homology like domain, family A, member 3 increases expression EXP Etoposide results in increased expression of PHLDA3 mRNA CTD PMID:25270620 NCBI chr 1:135,766,085...135,769,134
Ensembl chr 1:135,766,119...135,769,136
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A multiple interactions ISO [Cisplatin co-treated with Etoposide] results in increased mutagenesis of PIGA CTD PMID:21826740 NCBI chr  X:164,419,780...164,433,916
Ensembl chr  X:164,419,787...164,433,916
JBrowse link
G Pip5k1b phosphatidylinositol-4-phosphate 5-kinase, type 1 beta affects response to substance ISO PIP5K1B protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr19:24,294,794...24,555,872
Ensembl chr19:24,294,794...24,555,872
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO Etoposide results in increased expression of PLAU mRNA CTD PMID:21527772 NCBI chr14:20,836,662...20,843,388
Ensembl chr14:20,836,660...20,843,385
JBrowse link
G Plk1 polo like kinase 1 decreases expression EXP Etoposide results in decreased expression of PLK1 mRNA CTD PMID:25270620 NCBI chr 7:122,159,435...122,169,884
Ensembl chr 7:122,159,439...122,169,873
JBrowse link
G Plk2 polo like kinase 2 increases expression ISO Etoposide results in increased expression of PLK2 mRNA CTD PMID:21527772 NCBI chr13:110,395,044...110,400,844
Ensembl chr13:110,395,046...110,400,844
JBrowse link
G Plk3 polo like kinase 3 increases expression ISO Etoposide results in increased expression of PLK3 mRNA CTD PMID:17374387 NCBI chr 4:117,128,655...117,133,963
Ensembl chr 4:117,128,655...117,133,963
JBrowse link
G Plp1 proteolipid protein (myelin) 1 affects response to substance ISO PLP1 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr  X:136,820,148...136,838,582
Ensembl chr  X:136,822,671...136,839,733
JBrowse link
G Plpp2 phospholipid phosphatase 2 decreases expression EXP Etoposide results in decreased expression of PLPP2 mRNA CTD PMID:25270620 NCBI chr10:79,526,424...79,533,787
Ensembl chr10:79,526,430...79,533,796
JBrowse link
G Pm20d1 peptidase M20 domain containing 1 increases expression EXP Etoposide results in increased expression of PM20D1 mRNA CTD PMID:25270620 NCBI chr 1:131,797,385...131,821,472
Ensembl chr 1:131,797,381...131,821,473
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Etoposide results in increased expression of PMAIP1 mRNA CTD PMID:21801448 NCBI chr18:66,458,604...66,465,558
Ensembl chr18:66,458,533...66,465,565
JBrowse link
G Pmel premelanosome protein affects response to substance ISO PMEL protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr10:128,695,888...128,720,238
Ensembl chr10:128,704,195...128,720,238
JBrowse link
G Pmp2 peripheral myelin protein 2 affects response to substance ISO PMP2 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 3:10,179,851...10,183,885
Ensembl chr 3:10,179,851...10,183,929
JBrowse link
G Pmp22 peripheral myelin protein 22 affects response to substance ISO PMP22 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr11:63,128,982...63,159,547
Ensembl chr11:63,128,982...63,159,547
JBrowse link
G Polq polymerase (DNA directed), theta decreases response to substance EXP POLQ results in decreased susceptibility to Etoposide CTD PMID:21883722 NCBI chr16:37,011,741...37,095,419
Ensembl chr16:37,011,786...37,095,417
JBrowse link
G Polr1h RNA polymerase I subunit H decreases response to substance
multiple interactions
ISO POLR1H protein results in decreased susceptibility to Etoposide
Verapamil inhibits the reaction [POLR1H protein results in decreased susceptibility to Etoposide]
CTD PMID:14726695 NCBI chr17:36,954,358...36,958,525
Ensembl chr17:36,954,356...36,958,559
JBrowse link
G Postn periostin, osteoblast specific factor increases expression ISO Etoposide results in increased expression of POSTN mRNA CTD PMID:29397400 NCBI chr 3:54,359,267...54,391,041
Ensembl chr 3:54,361,109...54,391,037
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression
multiple interactions
ISO Etoposide results in increased expression of PPARGC1A mRNA
Etoposide promotes the reaction [PPARGC1A protein results in increased activity of ESRRA protein]
CTD PMID:26259609 PMID:30818834 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Ppargc1b peroxisome proliferative activated receptor, gamma, coactivator 1 beta increases expression ISO Etoposide results in increased expression of PPARGC1B mRNA CTD PMID:26259609 NCBI chr18:61,291,445...61,400,756
Ensembl chr18:61,298,136...61,400,431
JBrowse link
G Ppm1d protein phosphatase 1D magnesium-dependent, delta isoform increases expression ISO Etoposide results in increased expression of PPM1D protein CTD PMID:25078064 NCBI chr11:85,311,254...85,347,071
Ensembl chr11:85,311,244...85,347,066
JBrowse link
G Ppp1r13l protein phosphatase 1, regulatory subunit 13 like decreases response to substance
multiple interactions
increases expression
ISO PPP1R13L results in decreased susceptibility to Etoposide
Etoposide results in increased expression of and results in increased localization of PPP1R13L protein
Etoposide results in increased expression of PPP1R13L mRNA
CTD PMID:17570360 PMID:19299014 NCBI chr 7:19,359,724...19,378,540
Ensembl chr 7:19,359,749...19,378,533
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO Etoposide results in decreased expression of PRC1 mRNA CTD PMID:17374387 NCBI chr 7:80,294,445...80,316,259
Ensembl chr 7:80,294,450...80,316,259
JBrowse link
G Prdx1 peroxiredoxin 1 decreases expression EXP Etoposide results in decreased expression of PRDX1 protein CTD PMID:29733421 NCBI chr 4:116,685,599...116,700,000
Ensembl chr 4:116,685,544...116,700,822
JBrowse link
G Prkab1 protein kinase, AMP-activated, beta 1 non-catalytic subunit increases expression ISO Etoposide results in increased expression of PRKAB1 mRNA CTD PMID:24211769 NCBI chr 5:116,013,586...116,024,503
Ensembl chr 5:116,013,586...116,024,508
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO Etoposide results in increased cleavage of and results in increased activity of PRKCD protein CTD PMID:19662097 NCBI chr14:30,595,353...30,626,414
Ensembl chr14:30,595,354...30,626,210
JBrowse link
G Prkcz protein kinase C, zeta increases response to substance ISO PRKCZ protein results in increased susceptibility to Etoposide CTD PMID:21863889 NCBI chr 4:155,260,118...155,361,428
Ensembl chr 4:155,260,129...155,361,361
JBrowse link
G Prkdc protein kinase, DNA activated, catalytic polypeptide increases phosphorylation
multiple interactions
ISO Etoposide results in increased phosphorylation of PRKDC protein
PRKDC protein promotes the reaction [Etoposide results in increased phosphorylation of SP1 protein]
CTD PMID:17441964 NCBI chr16:15,637,444...15,842,239
Ensembl chr16:15,637,866...15,842,235
JBrowse link
G Prkx protein kinase, X-linked increases expression ISO Etoposide results in increased expression of PRKX mRNA CTD PMID:29397400 NCBI chr  X:77,760,972...77,796,235
Ensembl chr  X:77,761,411...77,796,278
JBrowse link
G Prnp prion protein decreases response to substance ISO PRNP protein results in decreased susceptibility to Etoposide CTD PMID:15386405 NCBI chr 2:131,909,928...131,938,436
Ensembl chr 2:131,909,928...131,938,429
JBrowse link
G Procr protein C receptor, endothelial increases expression ISO Etoposide results in increased expression of PROCR mRNA CTD PMID:21527772 NCBI chr 2:155,751,125...155,755,478
Ensembl chr 2:155,751,117...155,755,471
JBrowse link
G Psmd13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 multiple interactions EXP [Etoposide co-treated with Cisplatin co-treated with Bleomycin] results in decreased expression of PSMD13 protein CTD PMID:29733421 NCBI chr 7:140,882,394...140,898,642
Ensembl chr 7:140,881,968...140,898,643
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
increases response to substance
ISO PTEN protein inhibits the reaction [Etoposide results in increased phosphorylation of and results in increased activity of AKT1 protein]; PTEN protein modified form promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; PTEN protein promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide] CTD PMID:16807353 PMID:17935137 NCBI chr19:32,757,577...32,826,160
Ensembl chr19:32,757,497...32,826,160
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO Etoposide results in increased expression of PTGS2 protein
PTGS2 mutant form inhibits the reaction [VEGFC protein results in decreased susceptibility to Etoposide]
CTD PMID:24184161 PMID:26259609 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227
JBrowse link
G Pus3 pseudouridine synthase 3 decreases expression ISO Etoposide results in decreased expression of PUS3 mRNA CTD PMID:24211769 NCBI chr 9:35,558,560...35,567,401
Ensembl chr 9:35,558,595...35,567,401
JBrowse link
G Pygm muscle glycogen phosphorylase decreases expression ISO Etoposide results in decreased expression of PYGM mRNA CTD PMID:29397400 NCBI chr19:6,384,408...6,398,464
Ensembl chr19:6,384,399...6,398,459
JBrowse link
G Rab17 RAB17, member RAS oncogene family affects response to substance ISO RAB17 protein affects the susceptibility to Etoposide CTD PMID:16217747 NCBI chr 1:90,958,133...90,969,673
Ensembl chr 1:90,958,133...90,969,661
JBrowse link
G Rab20 RAB20, member RAS oncogene family affects response to substance