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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:(2S,3R,2'S)-nadolol
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Accession:CHEBI:60918 term browser browse the term
Definition:An aromatic ether, being the (2S)-3-(tert-butylamino)-2-hydroxypropyl ether of the phenolic hydroxy group of (6S,7R)-5,6,7,8-tetrahydronaphthalene-1,6,7-triol.
Synonyms:exact_synonym: (2S,3R)-5-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-1,2,3,4-tetrahydronaphthalene-2,3-diol
 related_synonym: Formula=C17H27NO4;   InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12-,14-,15+/m0/s1;   InChIKey=VWPOSFSPZNDTMJ-AEGPPILISA-N;   SMILES=CC(C)(C)NC[C@H](O)COc1cccc2C[C@H](O)[C@H](O)Cc12;   SQ 12150
 xref: CAS:54933-35-6;   Reaxys:7518265
 cyclic_relationship: is_enantiomer_of CHEBI:60917


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nadolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Nadolol inhibits the reaction [[CGP 12177 binds to ADRB1 protein] which results in increased abundance of Cyclic AMP] CTD PMID:15060759 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO [Nadolol binds to ADRB2 protein] which results in decreased abundance of Cyclic AMP CTD PMID:17925438 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Nadolol co-treated with Mifepristone] promotes the reaction [methyldithiocarbamate promotes the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]] CTD PMID:16321413 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO [Nadolol co-treated with Mifepristone] inhibits the reaction [methyldithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased secretion of IL12B protein]] CTD PMID:16321413 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Nadolol inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20845
    role 20805
      application 20606
        NMR chemical shift reference compound 18434
          ammonia 18228
            organic amino compound 18228
              secondary amino compound 6992
                (2S,3R,2'S)-nadolol 5
                  nadolol 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 20845
    subatomic particle 20843
      composite particle 20843
        hadron 20843
          baryon 20843
            nucleon 20843
              atomic nucleus 20843
                atom 20843
                  main group element atom 20766
                    main group molecular entity 20766
                      s-block molecular entity 20561
                        hydrogen molecular entity 20545
                          hydrides 19679
                            inorganic hydride 18572
                              pnictogen hydride 18558
                                nitrogen hydride 18469
                                  azane 18229
                                    ammonia 18228
                                      organic amino compound 18228
                                        secondary amino compound 6992
                                          (2S,3R,2'S)-nadolol 5
                                            nadolol 5
paths to the root