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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:polyamino carboxylic acid
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Accession:CHEBI:60892 term browser browse the term
Definition:An amino acid containing one or more nitrogen atoms connected through carbon atoms to one or more carboxy groups.
Synonyms:related_synonym: aminopolycarboxylic acid;   aminopolycarboxylic acids;   complexone;   complexones;   polyamino carboxylic acids
 xref: Wikipedia:Aminopolycarboxylic_acid


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BAPTA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein] CTD PMID:21908651 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Agt angiotensinogen multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [AGT protein modified form results in increased abundance of Superoxides] CTD PMID:12606818 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in decreased phosphorylation of AKT1 protein] CTD PMID:25433145 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atf6 activating transcription factor 6 increases expression
multiple interactions
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of ATF6 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6 protein]
CTD PMID:28181380 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
G Atf6b activating transcription factor 6 beta multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of ATF6B protein]
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of ATF6B protein
CTD PMID:28181380 NCBI chr20:4,414,283...4,422,283
Ensembl chr20:4,414,276...4,422,283
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Diclofenac results in increased activity of BID protein] CTD PMID:18191430 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid affects the reaction [Methacholine Chloride affects the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:12663092 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Capn1 calpain 1 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN1 protein] CTD PMID:28181380 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CAPN2 protein]
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of CAPN2 protein
CTD PMID:28181380 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp12 caspase 12 multiple interactions
increases expression
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP12 protein]
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of CASP12 protein
CTD PMID:28181380 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased activity of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein]
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [GW 7845 results in increased activity of CASP3 protein]; [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]
CTD PMID:19927300, PMID:20810541, PMID:28181380, PMID:29111403 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 increases expression
multiple interactions
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of CASP4 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of CASP4 protein]
CTD PMID:28181380 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]; [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased phosphorylation of CREB1 protein CTD PMID:21443188 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]] CTD PMID:21443188 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [GW 7845 affects the localization of CYCS protein] CTD PMID:20810541 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of DDIT3 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; [Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of DDIT3 protein]
CTD PMID:28181380, PMID:29111403 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases expression
ISO [fisetin co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased expression of EIF2AK3 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in increased expression of EIF2AK3 protein
CTD PMID:28181380 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Ionomycin results in increased expression of FOS mRNA]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [PDGFB protein results in increased expression of FOS mRNA]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA] CTD PMID:9650640 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in decreased phosphorylation of GSK3B protein] CTD PMID:25433145 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA] CTD PMID:21443188 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Humic Substances results in increased expression of HSP90AA1 protein] CTD PMID:23836447 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Humic Substances results in increased expression of HSP90AB1 protein] CTD PMID:23836447 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [fisetin results in increased expression of HSPA5 protein] CTD PMID:28181380 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [tributyltin results in increased expression of IL1A protein] CTD PMID:9221826 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein] CTD PMID:20371970 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein] CTD PMID:21908651 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAPK3 mRNA] CTD PMID:28836330 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] CTD PMID:19927300 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Acrolein results in increased expression of MMP9 protein] CTD PMID:19371603 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization
multiple interactions
ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid affects the localization of NFE2L2 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [CREBBP protein binds to NFE2L2 protein]]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2-tert-butylhydroquinone results in increased activity of NFE2L2 protein]
CTD PMID:21443188 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Humic Substances results in increased expression of and results in increased phosphorylation of NOS3 protein] CTD PMID:23836447 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased activity of PARP1 protein]
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid co-treated with Egtazic Acid] inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
CTD PMID:24752504, PMID:29111403 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [PDGFB protein results in increased expression of FOS mRNA] CTD PMID:9650640 NCBI chr 7:121,215,458...121,233,092
Ensembl chr 7:121,214,628...121,232,741
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [diphenylditelluride results in decreased expression of PRKACA protein] CTD PMID:21863293 NCBI chr19:25,095,089...25,118,869
Ensembl chr19:25,095,089...25,118,860
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions
decreases phosphorylation
ISO oxophenylarsine inhibits the reaction [1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased phosphorylation of RPS6KB1 protein] CTD PMID:16183647 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sct secretin multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT] CTD PMID:22194894 NCBI chr 1:214,264,865...214,277,437
Ensembl chr 1:214,264,754...214,265,668
JBrowse link
G Snca synuclein alpha multiple interactions EXP 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Rotenone results in increased expression of and results in increased phosphorylation of SNCA protein] CTD PMID:25433145 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases degradation ISO 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid results in decreased degradation of XIAP protein CTD PMID:16223472 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
ethylenediaminetetraacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases activity
ISO Zinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein] CTD PMID:28544013 NCBI chr10:94,170,766...94,213,831
Ensembl chr10:94,170,766...94,187,822
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Edetic Acid results in decreased metabolism of and results in decreased secretion of ACHE protein CTD PMID:23047022 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Anpep alanyl aminopeptidase, membrane multiple interactions ISO Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 1:141,561,364...141,604,249
Ensembl chr 1:141,561,334...141,604,273
JBrowse link
G Aplp1 amyloid beta precursor like protein 1 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein] CTD PMID:24855651 NCBI chr 1:88,897,525...88,908,750
Ensembl chr 1:88,897,532...88,908,750
JBrowse link
G Aplp2 amyloid beta precursor like protein 2 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein] CTD PMID:24855651 NCBI chr 8:32,298,526...32,328,821
Ensembl chr 8:32,298,532...32,328,839
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Aspa aspartoacylase decreases activity ISO Edetic Acid results in decreased activity of ASPA protein CTD PMID:17027983 NCBI chr10:59,839,693...59,888,244
Ensembl chr10:59,839,852...59,892,960
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP [ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 1:197,855,912...197,875,038 JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein] CTD PMID:18369157 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Cat catalase multiple interactions ISO CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cp ceruloplasmin multiple interactions ISO Edetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl] CTD PMID:22824865 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Edetic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions ISO Edetic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of and results in increased phosphorylation of DLD protein] CTD PMID:29158198 NCBI chr 6:50,597,677...50,618,694
Ensembl chr 6:50,597,677...50,618,694
JBrowse link
G Dspp dentin sialophosphoprotein affects localization EXP Edetic Acid affects the localization of DSPP protein CTD PMID:23525114 NCBI chr14:6,926,972...6,933,079
Ensembl chr14:6,926,976...6,933,070
JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Edetic Acid inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr13:91,018,670...91,019,862
Ensembl chr13:91,018,510...91,020,112
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in decreased activity of ENPP7 protein] CTD PMID:12885774 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Edetic Acid results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:10720163 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases degradation EXP Edetic Acid results in decreased degradation of IGFBP5 protein CTD PMID:8894652 NCBI chr 9:80,154,230...80,166,813
Ensembl chr 9:80,150,211...80,167,033
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]] CTD PMID:11238657 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Edetic Acid results in increased expression of ITGAM protein CTD PMID:8595612 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Mbp myelin basic protein affects expression EXP Edetic Acid affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mgp matrix Gla protein multiple interactions ISO [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]; Edetic Acid inhibits the reaction [Calcium binds to MGP protein] CTD PMID:18369157 NCBI chr 4:170,856,783...170,860,105
Ensembl chr 4:170,856,751...170,860,225
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Edetic Acid results in decreased activity of MMP8 protein CTD PMID:15057751 NCBI chr 8:5,768,808...5,777,741
Ensembl chr 8:5,768,811...5,778,702
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Edetic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]] CTD PMID:14998373 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt3 metallothionein 3 increases alkylation
affects metabolic processing
ISO Edetic Acid results in increased alkylation of MT3 protein
MT3 protein polymorphism affects the metabolism of Edetic Acid
CTD PMID:12383939, PMID:14983064 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Neil1 nei-like DNA glycosylase 1 multiple interactions ISO [tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; Edetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein] CTD PMID:20622253 NCBI chr 8:61,817,258...61,824,023
Ensembl chr 8:61,817,258...61,823,102
JBrowse link
G Optc opticin multiple interactions ISO Edetic Acid inhibits the reaction [Oxygen deficiency results in increased degradation of OPTC protein]; Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr13:50,735,509...50,748,908
Ensembl chr13:50,735,599...50,746,354
JBrowse link
G Pgp phosphoglycolate phosphatase decreases activity ISO Edetic Acid results in decreased activity of PGP protein CTD PMID:24338473 NCBI chr10:13,836,105...13,838,731
Ensembl chr10:13,836,128...13,838,765
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein] CTD PMID:21615740 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Plg plasminogen multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein] CTD PMID:21615740 NCBI chr 1:48,521,828...48,563,895
Ensembl chr 1:48,521,772...48,563,776
JBrowse link
G Prl prolactin multiple interactions ISO Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prlr prolactin receptor multiple interactions ISO Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Prnp prion protein multiple interactions ISO Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein] CTD PMID:16595185 NCBI chr 3:124,515,917...124,531,320
Ensembl chr 3:124,515,978...124,531,316
JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G Sell selectin L decreases expression ISO Edetic Acid results in decreased expression of SELL protein CTD PMID:8595612 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Slc30a10 solute carrier family 30, member 10 increases expression
multiple interactions
ISO Edetic Acid results in increased expression of SLC30A10 mRNA; Edetic Acid results in increased expression of SLC30A10 protein
Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]
CTD PMID:22341971, PMID:22926781 NCBI chr13:103,396,295...103,406,759
Ensembl chr13:103,396,314...103,410,363
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions EXP Edetic Acid inhibits the reaction [Calcium results in increased cleavage of SPTAN1 protein] CTD PMID:17069801 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Edetic Acid results in increased expression of TNF protein CTD PMID:29953848 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp63 tumor protein p63 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Edetic Acid inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]] CTD PMID:17442041 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases activity
multiple interactions
ISO Edetic Acid results in increased activity of TXNRD1 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]
CTD PMID:16774913 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Txnrd3 thioredoxin reductase 3 increases activity
multiple interactions
ISO Edetic Acid results in increased activity of TXNRD3 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD3 protein]
CTD PMID:16774913 NCBI chr 4:121,612,332...121,650,543
Ensembl chr 4:121,612,332...121,650,571
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens; CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        refrigerant 17443
          ammonia 16961
            organic amino compound 16960
              amino acid 14080
                polyamino carboxylic acid 90
                  5,5'-dibromo-BAPTA 0
                  5,5'-dimethyl-BAPTA 0
                  BAPTA + 39
                  ethylenediaminediacetic acid 0
                  ethylenediaminetetraacetic acid 51
                  ethylenediaminetriacetic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19792
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19571
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18508
                              organic divalent group 18501
                                organodiyl group 18501
                                  carbonyl group 18404
                                    carbonyl compound 18404
                                      carboxylic acid 18079
                                        amino acid 14080
                                          polyamino carboxylic acid 90
                                            5,5'-dibromo-BAPTA 0
                                            5,5'-dimethyl-BAPTA 0
                                            BAPTA + 39
                                            ethylenediaminediacetic acid 0
                                            ethylenediaminetetraacetic acid 51
                                            ethylenediaminetriacetic acid 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.