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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:beta-carbolines
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Accession:CHEBI:60834 term browser browse the term
Definition:Any pyridoindole containing a beta-carboline skeleton and their hydrogenated derivatives
Synonyms:related_synonym: 9H-pyrido[3,4-b]indoles
 xref: PMID:1967844

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annomontine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression ISO annomontine results in increased expression of AHR mRNA CTD PMID:20449727 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO annomontine results in increased expression of AHRR mRNA CTD PMID:20449727 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO annomontine results in increased expression of CYP1A1 mRNA CTD PMID:20449727 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
beta-carboline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
increases activity		 ISO norharman inhibits the reaction [Lipids metabolite results in increased activity of AHR protein]
norharman results in increased activity of AHR protein		 CTD PMID:27020609 PMID:28336214 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO CYP1A1 protein affects the metabolism of [norharman co-treated with aniline]
norharman results in increased expression of CYP1A1 mRNA; norharman results in increased expression of CYP1A1 protein		 CTD PMID:15279827 PMID:28336214 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO CYP2B6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO CYP2E1 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO CYP3A4 protein affects the metabolism of [norharman co-treated with aniline] CTD PMID:15279827 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO norharman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Maob monoamine oxidase B multiple interactions
decreases activity		 ISO norharman inhibits the reaction [MAOB protein results in increased oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine]
norharman results in decreased activity of MAOB protein		 CTD PMID:21554916 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions		 ISO norharman results in decreased activity of SLC22A1 protein
norharman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions		 ISO norharman results in decreased activity of SLC22A2 protein
norharman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 decreases activity
multiple interactions		 ISO norharman results in decreased activity of SLC22A3 protein
norharman inhibits the reaction [SLC22A3 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256 		JBrowse link
Evodiamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of ABCB1 protein] CTD PMID:15710601 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO evodiamine inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; wortmannin promotes the reaction [evodiamine results in decreased phosphorylation of AKT1 protein]
evodiamine inhibits the reaction [INS1 results in increased phosphorylation of AKT1 protein]		 CTD PMID:15710601 PMID:17884939 PMID:20005289 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases cleavage		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [evodiamine results in increased cleavage of BCL2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2 protein] CTD PMID:15710601 PMID:20005289 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2a1 BCL2-related protein A1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein] CTD PMID:15710601 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein] CTD PMID:15710601 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC2 protein] CTD PMID:15710601 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC3 protein] CTD PMID:15710601 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC5 protein] CTD PMID:15710601 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [evodiamine results in increased activity of and results in increased cleavage of CASP3 protein]; evodiamine results in increased activity of and results in increased cleavage of CASP3 protein CTD PMID:20005289 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15710601 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of CFLAR protein] CTD PMID:15710601 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased activity of CHUK protein] CTD PMID:15710601 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation		 ISO EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PLCG1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of EGFR protein] CTD PMID:19854188 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [evodiamine results in increased expression of FASLG protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [evodiamine results in increased expression of FASLG protein]; wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein] CTD PMID:20005289 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15710601 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased activity of IKBKB protein] CTD PMID:15710601 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO evodiamine inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [IL1B protein results in increased activity of RELA protein] CTD PMID:15710601 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK1 protein] CTD PMID:17884939 PMID:19854188 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO chelerythrine inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of MAPK3 protein] CTD PMID:17884939 PMID:19854188 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases expression		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [evodiamine results in increased expression of MAPK8 protein modified form] CTD PMID:23774672 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [evodiamine results in increased expression of MAPK9 protein modified form] CTD PMID:23774672 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of MMP9 protein] CTD PMID:15710601 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of MYC protein] CTD PMID:15710601 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO evodiamine inhibits the reaction [Hydrogen Peroxide results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [Okadaic Acid results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein] CTD PMID:15710601 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; evodiamine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; evodiamine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein; wortmannin inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:15710601 PMID:20005289 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO evodiamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17109845 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO evodiamine promotes the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:15710601 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions
increases phosphorylation		 ISO EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PLCG1 protein] CTD PMID:19854188 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO evodiamine results in decreased expression of PPARG CTD PMID:17884939 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions
increases phosphorylation		 ISO EGFR mutant form inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein]; RTKI cpd inhibits the reaction [evodiamine results in increased phosphorylation of PRKCA protein] CTD PMID:19854188 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of PTGS2 protein] CTD PMID:15710601 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO evodiamine inhibits the reaction [Hydrogen Peroxide results in increased activity of RELA protein]; evodiamine inhibits the reaction [IL1B protein results in increased activity of RELA protein]; evodiamine inhibits the reaction [Okadaic Acid results in increased activity of RELA protein]; evodiamine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of RELA protein]; evodiamine inhibits the reaction [TNF protein affects the localization of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [TNF protein results in increased activity of RELA protein] CTD PMID:15710601 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO evodiamine inhibits the reaction [TNF protein affects the localization of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased acetylation of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]; evodiamine inhibits the reaction [TNF protein results in increased activity of AKT1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of CHUK protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of IKBKB protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]; evodiamine inhibits the reaction [TNF protein results in increased activity of RELA protein]; evodiamine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of ABCB1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2A1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC3 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of BIRC5 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of CFLAR protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of MYC protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; evodiamine inhibits the reaction [TNF protein results in increased expression of XIAP protein]; evodiamine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; evodiamine promotes the reaction [TNF protein results in increased cleavage of PARP1 protein] CTD PMID:15710601 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO evodiamine inhibits the reaction [TNF protein results in increased expression of XIAP protein] CTD PMID:15710601 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
harmaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability		 ISO [Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with Harmaline] results in decreased expression of CYP1A1 protein]; Harmaline inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Harmaline inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Harmaline results in decreased activity of CYP1A1 protein
Harmaline results in decreased stability of CYP1A1 protein		 CTD PMID:22037238 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Maoa monoamine oxidase A decreases activity EXP
ISO		 Harmaline results in decreased activity of MAOA protein CTD PMID:15178694 PMID:24373881 PMID:28302559 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Harmaline inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Harmaline inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] CTD PMID:12065299 PMID:12107048 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
harmalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity
increases expression		 ISO harmalol results in increased activity of CASP3 protein
harmalol results in increased expression of CASP3 mRNA		 CTD PMID:27590872 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases stability
decreases activity		 ISO [Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Cycloheximide co-treated with harmalol] results in decreased expression of CYP1A1 protein]; harmalol inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; harmalol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
harmalol results in decreased stability of CYP1A1 protein
harmalol results in decreased activity of CYP1A1 protein		 CTD PMID:22037238 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO harmalol results in increased expression of TP53 mRNA; harmalol results in increased expression of TP53 protein CTD PMID:27590872 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
harman term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein] CTD PMID:20732341 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases activity
increases expression		 ISO
EXP		 AHR mutant form inhibits the reaction [harman results in increased activity of CYP1A1 protein]; AHR mutant form inhibits the reaction [harman results in increased expression of CYP1A1 protein]; Dactinomycin inhibits the reaction [harman results in increased expression of CYP1A1 mRNA]; resveratrol inhibits the reaction [harman results in increased activity of CYP1A1 protein]
harman results in increased expression of CYP1A1 mRNA; harman results in increased expression of CYP1A1 protein		 CTD PMID:20732341 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Maoa monoamine oxidase A decreases activity ISO harman results in decreased activity of MAOA protein CTD PMID:28057462 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases activity		 ISO harman inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
harman results in decreased activity of SLC22A1 protein		 CTD PMID:30189235 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 decreases activity
multiple interactions		 ISO harman results in decreased activity of SLC22A2 protein
harman inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]		 CTD PMID:30189235 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO harman results in increased activity of TAAR1 protein
[harman results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475 		JBrowse link
harmine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Harmine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] CTD PMID:22001777 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Axin2 axin 2 multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642 		JBrowse link
G Bcl2l11 BCL2 like 11 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased expression of BCL2L11 protein] CTD PMID:30171258 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192 		JBrowse link
G Ccna1 cyclin A1 increases expression ISO Harmine results in increased expression of CCNA1 mRNA; Harmine results in increased expression of CCNA1 protein CTD PMID:25751815 NCBI chr 2:144,456,689...144,503,570
Ensembl chr 2:144,458,153...144,467,912 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO Harmine results in increased expression of CCNE2 mRNA; Harmine results in increased expression of CCNE2 protein CTD PMID:25751815 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406 		JBrowse link
G Cdc25a cell division cycle 25A increases expression ISO Harmine results in increased expression of CDC25A mRNA CTD PMID:25751815 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519 		JBrowse link
G Cdc25c cell division cycle 25C increases expression ISO Harmine results in increased expression of CDC25C mRNA CTD PMID:25751815 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression ISO Harmine results in increased expression of CDK1 mRNA; Harmine results in increased expression of CDK1 protein CTD PMID:25751815 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases phosphorylation EXP Harmine results in decreased phosphorylation of CDKN1B protein CTD PMID:26953159 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn1c cyclin-dependent kinase inhibitor 1C decreases expression ISO Harmine results in decreased expression of CDKN1C mRNA; Harmine results in decreased expression of CDKN1C protein CTD PMID:25751815 NCBI chr 1:216,661,067...216,663,791
Ensembl chr 1:216,661,080...216,663,721 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases expression ISO Harmine results in decreased expression of CDKN2A mRNA; Harmine results in decreased expression of CDKN2A protein CTD PMID:25751815 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B decreases expression ISO Harmine results in decreased expression of CDKN2B mRNA CTD PMID:25751815 NCBI chr 5:107,834,353...107,857,428
Ensembl chr 5:107,845,951...107,858,104 		JBrowse link
G Chd4 chromodomain helicase DNA binding protein 4 multiple interactions
increases phosphorylation		 ISO AZD 6244 inhibits the reaction [Harmine results in increased phosphorylation of CHD4 protein]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter] CTD PMID:27805061 NCBI chr 4:157,612,531...157,645,660
Ensembl chr 4:157,612,536...157,645,659 		JBrowse link
G Cidea cell death-inducing DFFA-like effector a multiple interactions
increases expression		 ISO Harmine affects the reaction [Dietary Fats affects the expression of CIDEA mRNA]
Harmine results in increased expression of CIDEA protein		 CTD PMID:27805061 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases stability		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Harmine results in decreased stability of CYP1A1 protein]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Harmine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Harmine results in decreased activity of CYP1A1 protein		 CTD PMID:22001777 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Harmine results in increased expression of DIO2 protein CTD PMID:27805061 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A multiple interactions
affects binding
decreases activity		 ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein]
Harmine binds to DYRK1A protein
Harmine results in decreased activity of DYRK1A protein		 CTD PMID:21573099 PMID:25751815 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO Harmine results in increased expression of E2F1 mRNA; Harmine results in increased expression of E2F1 protein CTD PMID:25751815 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721 		JBrowse link
G E2f2 E2F transcription factor 2 increases expression ISO Harmine results in increased expression of E2F2 mRNA; Harmine results in increased expression of E2F2 protein CTD PMID:25751815 NCBI chr 5:154,516,611...154,540,228
Ensembl chr 5:154,522,119...154,540,265 		JBrowse link
G E2f7 E2F transcription factor 7 increases expression ISO Harmine results in increased expression of E2F7 mRNA CTD PMID:25751815 NCBI chr 7:53,275,659...53,318,261
Ensembl chr 7:53,275,676...53,316,481 		JBrowse link
G E2f8 E2F transcription factor 8 increases expression ISO Harmine results in increased expression of E2F8 mRNA CTD PMID:25751815 NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [phenylamil co-treated with Harmine] results in increased expression of FABP4 mRNA CTD PMID:20519739 NCBI chr 2:93,792,666...93,797,267
Ensembl chr 2:93,792,601...93,797,305 		JBrowse link
G Foxm1 forkhead box M1 increases expression ISO Harmine results in increased expression of FOXM1 mRNA; Harmine results in increased expression of FOXM1 protein CTD PMID:25751815 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305 		JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA] CTD PMID:20519739 NCBI chr 6:44,360,077...44,361,908
Ensembl chr 6:44,348,501...44,363,915 		JBrowse link
G Ins2 insulin 2 increases expression ISO Harmine results in increased expression of INS mRNA CTD PMID:25751815 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Lepr leptin receptor multiple interactions ISO Harmine affects the reaction [LEPR protein affects the susceptibility to INS1 protein] CTD PMID:27805061 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Mafa MAF bZIP transcription factor A increases expression ISO Harmine results in increased expression of MAFA mRNA; Harmine results in increased expression of MAFA protein CTD PMID:25751815 NCBI chr 7:116,779,368...116,781,815
Ensembl chr 7:116,780,681...116,781,766 		JBrowse link
G Maoa monoamine oxidase A decreases activity EXP
ISO		 Harmine results in decreased activity of MAOA protein CTD PMID:24373881 PMID:28302559 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Harmine results in increased phosphorylation of MAPK1 protein CTD PMID:27805061 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Harmine results in increased phosphorylation of MAPK3 protein CTD PMID:27805061 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapt microtubule-associated protein tau multiple interactions ISO Harmine inhibits the reaction [DYRK1A protein results in increased phosphorylation of MAPT protein] CTD PMID:21573099 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Harmine results in increased expression of MYC protein CTD PMID:25751815 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240 		JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 affects localization ISO Harmine affects the localization of NFATC1 protein CTD PMID:25751815 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690 		JBrowse link
G Nfatc2 nuclear factor of activated T-cells 2 affects localization ISO Harmine affects the localization of NFATC2 protein CTD PMID:25751815 NCBI chr 3:165,241,750...165,374,644
Ensembl chr 3:165,245,238...165,360,292 		JBrowse link
G Nfatc3 nuclear factor of activated T-cells 3 affects localization ISO Harmine affects the localization of NFATC3 protein CTD PMID:25751815 NCBI chr19:38,039,542...38,114,003
Ensembl chr19:38,039,564...38,114,003 		JBrowse link
G Nfatc4 nuclear factor of activated T-cells 4 affects localization ISO Harmine affects the localization of NFATC4 protein CTD PMID:25751815 NCBI chr15:34,493,163...34,502,238
Ensembl chr15:34,493,138...34,504,326 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Harmine promotes the reaction [Erlotinib Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:30171258 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression ISO Harmine results in increased expression of PDX1 mRNA; Harmine results in increased expression of PDX1 protein CTD PMID:25751815 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO [phenylamil co-treated with Harmine] results in increased expression of PPARG mRNA
Harmine results in increased expression of PPARG protein		 CTD PMID:20519739 PMID:27805061 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression
multiple interactions		 ISO Harmine results in increased expression of PPARGC1A protein
Harmine affects the reaction [Dietary Fats affects the expression of PPARGC1A mRNA]		 CTD PMID:27805061 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Prdm16 PR/SET domain 16 increases expression
multiple interactions		 ISO Harmine results in increased expression of PRDM16 protein
Harmine affects the reaction [Dietary Fats affects the expression of PRDM16 mRNA]		 CTD PMID:27805061 NCBI chr 5:171,662,277...171,711,561
Ensembl chr 5:171,662,277...171,710,316 		JBrowse link
G Ucp1 uncoupling protein 1 increases expression
multiple interactions		 ISO Harmine results in increased expression of UCP1 mRNA; Harmine results in increased expression of UCP1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; AZD 6244 inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]; Harmine affects the reaction [Dietary Fats affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein affects the expression of UCP1 mRNA]; Harmine inhibits the reaction [CHD4 protein binds to UCP1 promoter]; N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholin-4-ylpropyl)-pyrimidine-2,4-diamine inhibits the reaction [Harmine results in increased expression of UCP1 mRNA]		 CTD PMID:27805061 NCBI chr19:24,456,976...24,464,808
Ensembl chr19:24,456,976...24,464,807 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions ISO Harmine inhibits the reaction [WNT3A protein results in decreased expression of ID2 mRNA]; Harmine inhibits the reaction [WNT3A protein results in increased expression of AXIN2 mRNA] CTD PMID:20519739 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035 		JBrowse link
Rutecarpine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases localization
increases expression
multiple interactions
affects binding		 ISO
EXP		 rutecarpine results in increased localization of AHR protein
rutecarpine results in increased expression of AHR mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine results in increased localization of AHR protein]; AHR affects the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; rutecarpine promotes the reaction [AHR protein binds to CYP1A1 promoter]; W 7 inhibits the reaction [rutecarpine results in increased localization of AHR protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine binds to AHR protein]; rutecarpine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; W 7 inhibits the reaction [rutecarpine binds to AHR protein]		 CTD PMID:19853001 PMID:20449727 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ahrr aryl-hydrocarbon receptor repressor increases expression ISO rutecarpine results in increased expression of AHRR mRNA CTD PMID:20449727 NCBI chr 1:31,603,297...31,698,329
Ensembl chr 1:31,603,297...31,698,329 		JBrowse link
G Bmpr1a bone morphogenetic protein receptor type 1A decreases expression ISO rutecarpine results in decreased expression of BMPR1A mRNA CTD PMID:25633564 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512 		JBrowse link
G Bmpr1b bone morphogenetic protein receptor type 1B decreases expression ISO rutecarpine results in decreased expression of BMPR1B mRNA CTD PMID:25633564 NCBI chr 2:247,392,195...247,662,026
Ensembl chr 2:247,403,920...247,446,882 		JBrowse link
G Bmpr2 bone morphogenetic protein receptor type 2 decreases expression ISO rutecarpine results in decreased expression of BMPR2 mRNA CTD PMID:25633564 NCBI chr 9:66,568,074...66,683,019
Ensembl chr 9:66,568,074...66,676,494 		JBrowse link
G Camk1 calcium/calmodulin-dependent protein kinase I increases phosphorylation ISO rutecarpine results in increased phosphorylation of CAMK1 protein CTD PMID:19853001 NCBI chr 4:145,289,300...145,300,146
Ensembl chr 4:145,288,996...145,300,177 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; KN 93 inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]; zinc protoporphyrin inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]] CTD PMID:28025122 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
affects binding
increases expression		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; AHR affects the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; AHR affects the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; capsazepine inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; capsazepine inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]; rutecarpine promotes the reaction [AHR protein binds to CYP1A1 promoter]; rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein; W 7 inhibits the reaction [rutecarpine results in increased activity of and results in increased expression of CYP1A1 protein]; W 7 inhibits the reaction [rutecarpine results in increased expression of CYP1A1 mRNA]
rutecarpine binds to CYP1A1 promoter
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [rutecarpine binds to CYP1A1 promoter]; W 7 inhibits the reaction [rutecarpine binds to CYP1A1 promoter]		 CTD PMID:19853001 PMID:20449727 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases activity		 EXP
ISO		 rutecarpine promotes the reaction [CYP1A2 protein affects the metabolism of Theophylline]
rutecarpine results in increased activity of CYP1A2 protein
rutecarpine analog binds to and results in decreased activity of CYP1A2 protein; rutecarpine binds to and results in decreased activity of CYP1A2 protein		 CTD PMID:12852960 PMID:15720787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO rutecarpine analog binds to and results in decreased activity of CYP1B1 protein CTD PMID:12852960 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Furin furin (paired basic amino acid cleaving enzyme) decreases expression ISO rutecarpine results in decreased expression of FURIN mRNA CTD PMID:25633564 NCBI chr 1:142,185,092...142,198,167
Ensembl chr 1:142,185,094...142,197,182 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein] CTD PMID:28025122 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions
decreases expression		 ISO rutecarpine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA]
rutecarpine results in decreased expression of HAMP mRNA		 CTD PMID:25633564 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960 		JBrowse link
G Hjv hemojuvelin BMP co-receptor decreases expression ISO rutecarpine results in decreased expression of HJV mRNA CTD PMID:25633564 NCBI chr 2:198,655,437...198,659,318
Ensembl chr 2:198,655,437...198,659,317 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of HMOX1 protein] CTD PMID:28025122 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO rutecarpine inhibits the reaction [IL6 protein results in increased expression of HAMP mRNA] CTD PMID:25633564 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO rutecarpine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:17109845 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 protein] CTD PMID:28025122 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    chemical entity 19875
      atom 19873
        nonmetal atom 19751
          nitrogen atom 18640
            nitrogen molecular entity 18640
              organonitrogen compound 18414
                organonitrogen heterocyclic compound 17579
                  pyridoindole 114
                    beta-carbolines 97
                      11-Hydroxycanthin-6-one 0
                      2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 0
                      2-(2-methoxyethyl)-9-methyl-1-oxo-N-(thiophen-2-ylmethyl)-4-pyrido[3,4-b]indolecarboxamide 0
                      2-(2-methoxyethyl)-9-methyl-4-[(4-methyl-1-piperidinyl)-oxomethyl]-1-pyrido[3,4-b]indolone 0
                      2-(2-methoxyethyl)-9-methyl-N-[3-(4-methyl-1-piperidinyl)propyl]-1-oxo-4-pyrido[3,4-b]indolecarboxamide 0
                      2-cyclohexyl-9-methyl-1-oxo-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-4-pyrido[3,4-b]indolecarboxamide 0
                      2-cyclopentyl-4-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-9-methyl-1-pyrido[3,4-b]indolone 0
                      2-methyl-beta-carbolinium-6-ol 0
                      4,21-Dehydrocorynantheine aldehyde 0
                      4-(methoxymethyl)-6-phenylmethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester 0
                      4-[[9-methyl-2-(2-methylpropyl)-1-oxo-4-pyrido[3,4-b]indolyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester 0
                      4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester 0
                      4-methyl-5-propan-2-yloxy-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester 0
                      5,7-difluoro-6-methoxy-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one 0
                      5,8-dichloro-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one 0
                      5-bromo-8-methoxy-1-methyl-beta-carboline 0
                      6-Hydroxytetrahydro-beta-carboline 0
                      6-hydroxymanzamine A 0
                      6-methoxy-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one 0
                      7-fluoro-6-methoxy-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one 0
                      8-hydroxymanzamine A 0
                      9-Methyl-7-bromoeudistomin D 0
                      9H-pyrido[3,4-b]indol-3-ylmethanol 0
                      9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester 0
                      9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester 0
                      9H-pyrido[3,4-b]indole-3-carboxylic acid propyl ester 0
                      Angustine 0
                      Antirhine 0
                      Bleekerine 0
                      Callichiline 0
                      Corynantheal 0
                      Elaeocarpidine 0
                      Eudistomin C 0
                      Eudistomin N 0
                      Evodiamine 34
                      Gambirtannine 0
                      LSM-16248 0
                      LSM-1674 0
                      LSM-2017 0
                      LSM-2392 0
                      LSM-2643 0
                      LSM-2721 0
                      LSM-2986 0
                      LSM-3212 0
                      LSM-3213 0
                      LSM-3277 0
                      LSM-3319 0
                      LSM-3375 0
                      LSM-3388 0
                      LSM-3390 0
                      LSM-3463 0
                      LSM-3515 0
                      LSM-3544 0
                      LSM-3606 0
                      LSM-3794 0
                      LSM-3844 0
                      LSM-3853 0
                      LSM-3888 0
                      LSM-4020 0
                      LSM-4163 0
                      LSM-4208 0
                      LSM-4239 0
                      LSM-4272 0
                      LSM-6260 0
                      LSM-6483 0
                      Methyl nigakinone 0
                      N(2)-methylharmine 0
                      N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide 0
                      N-Butyl-beta-carboline-3-carboxylate 0
                      N-butylharmine 0
                      N-ethylharmine 0
                      N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide 0
                      Nigakinone 0
                      Rutecarpine 18
                      Sempervirine 0
                      Strictosamide 0
                      Trichotomine 0
                      alangimarckine 0
                      annomontine 3
                      beta-carboline + 14
                      beta-carboline alkaloid + 0
                      biriperone 0
                      cordysinin C 0
                      cordysinin D 0
                      cordysinin E 0
                      dihydroalstonine(1+) 0
                      gevotroline 0
                      harmala alkaloid + 52
                      manzamine A + 0
                      metralindole 0
                      nostocarboline 0
                      tetrahydropentoxyline 0
                      trans-Ned 19 0
                      tubulosine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      carbon group element atom 19668
                        carbon atom 19657
                          organic molecular entity 19657
                            organic molecule 19586
                              organic cyclic compound 19395
                                organic heterocyclic compound 18511
                                  organic heteropolycyclic compound 17900
                                    organic heterotricyclic compound 14606
                                      pyridoindole 114
                                        beta-carbolines 97
                                          11-Hydroxycanthin-6-one 0
                                          2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole 0
                                          2-(2-methoxyethyl)-9-methyl-1-oxo-N-(thiophen-2-ylmethyl)-4-pyrido[3,4-b]indolecarboxamide 0
                                          2-(2-methoxyethyl)-9-methyl-4-[(4-methyl-1-piperidinyl)-oxomethyl]-1-pyrido[3,4-b]indolone 0
                                          2-(2-methoxyethyl)-9-methyl-N-[3-(4-methyl-1-piperidinyl)propyl]-1-oxo-4-pyrido[3,4-b]indolecarboxamide 0
                                          2-cyclohexyl-9-methyl-1-oxo-N-[3-(2-oxo-1-pyrrolidinyl)propyl]-4-pyrido[3,4-b]indolecarboxamide 0
                                          2-cyclopentyl-4-[1,4-dioxa-8-azaspiro[4.5]decan-8-yl(oxo)methyl]-9-methyl-1-pyrido[3,4-b]indolone 0
                                          2-methyl-beta-carbolinium-6-ol 0
                                          4,21-Dehydrocorynantheine aldehyde 0
                                          4-(methoxymethyl)-6-phenylmethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester 0
                                          4-[[9-methyl-2-(2-methylpropyl)-1-oxo-4-pyrido[3,4-b]indolyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester 0
                                          4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester 0
                                          4-methyl-5-propan-2-yloxy-9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester 0
                                          5,7-difluoro-6-methoxy-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one 0
                                          5,8-dichloro-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one 0
                                          5-bromo-8-methoxy-1-methyl-beta-carboline 0
                                          6-Hydroxytetrahydro-beta-carboline 0
                                          6-hydroxymanzamine A 0
                                          6-methoxy-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one 0
                                          7-fluoro-6-methoxy-2,3,4,9-tetrahydropyrido[3,4-b]indol-1-one 0
                                          8-hydroxymanzamine A 0
                                          9-Methyl-7-bromoeudistomin D 0
                                          9H-pyrido[3,4-b]indol-3-ylmethanol 0
                                          9H-pyrido[3,4-b]indole-3-carboxylic acid ethyl ester 0
                                          9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester 0
                                          9H-pyrido[3,4-b]indole-3-carboxylic acid propyl ester 0
                                          Angustine 0
                                          Antirhine 0
                                          Bleekerine 0
                                          Callichiline 0
                                          Corynantheal 0
                                          Elaeocarpidine 0
                                          Eudistomin C 0
                                          Eudistomin N 0
                                          Evodiamine 34
                                          Gambirtannine 0
                                          LSM-16248 0
                                          LSM-1674 0
                                          LSM-2017 0
                                          LSM-2392 0
                                          LSM-2643 0
                                          LSM-2721 0
                                          LSM-2986 0
                                          LSM-3212 0
                                          LSM-3213 0
                                          LSM-3277 0
                                          LSM-3319 0
                                          LSM-3375 0
                                          LSM-3388 0
                                          LSM-3390 0
                                          LSM-3463 0
                                          LSM-3515 0
                                          LSM-3544 0
                                          LSM-3606 0
                                          LSM-3794 0
                                          LSM-3844 0
                                          LSM-3853 0
                                          LSM-3888 0
                                          LSM-4020 0
                                          LSM-4163 0
                                          LSM-4208 0
                                          LSM-4239 0
                                          LSM-4272 0
                                          LSM-6260 0
                                          LSM-6483 0
                                          Methyl nigakinone 0
                                          N(2)-methylharmine 0
                                          N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide 0
                                          N-Butyl-beta-carboline-3-carboxylate 0
                                          N-butylharmine 0
                                          N-ethylharmine 0
                                          N-methyl-9H-pyrido[3,4-b]indole-3-carboxamide 0
                                          Nigakinone 0
                                          Rutecarpine 18
                                          Sempervirine 0
                                          Strictosamide 0
                                          Trichotomine 0
                                          alangimarckine 0
                                          annomontine 3
                                          beta-carboline + 14
                                          beta-carboline alkaloid + 0
                                          biriperone 0
                                          cordysinin C 0
                                          cordysinin D 0
                                          cordysinin E 0
                                          dihydroalstonine(1+) 0
                                          gevotroline 0
                                          harmala alkaloid + 52
                                          manzamine A + 0
                                          metralindole 0
                                          nostocarboline 0
                                          tetrahydropentoxyline 0
                                          trans-Ned 19 0
                                          tubulosine 0
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