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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fluprostenol
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Accession:CHEBI:60782 term browser browse the term
Definition:An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea.
Synonyms:exact_synonym: rac-(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoic acid
 related_synonym: EINECS 255-029-3;   Formula=C23H29F3O6;   ICI 81,008;   InChI=1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1;   InChIKey=WWSWYXNVCBLWNZ-QIZQQNKQSA-N;   SMILES=O[C@@H](COc1cccc(c1)C(F)(F)F)\\C=C\\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O;   fluprostenolum;   travoprost acid;   travoprost free acid
 xref: CAS:40666-16-8
 xref_mesh: MESH:C006326
 xref: PMID:11832489;   PMID:11929662;   PMID:550147;   PMID:6090118;   PMID:6911921;   PMID:6916556;   PMID:941381;   PMID:951924;   Reaxys:8368795



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fluprostenol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp4 fatty acid binding protein 4 multiple interactions ISO fluprostenol inhibits the reaction [Niacin results in increased expression of FABP4 mRNA] CTD PMID:21236357 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression EXP fluprostenol results in decreased expression of FGFR2 mRNA CTD PMID:15654655 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]] CTD PMID:33486071 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]] CTD PMID:33486071 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK1 protein]
fluprostenol results in increased phosphorylation of MAPK1 protein
CTD PMID:33486071 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO fluprostenol promotes the reaction [Oxidopamine results in increased phosphorylation of MAPK3 protein]
fluprostenol results in increased phosphorylation of MAPK3 protein
CTD PMID:33486071 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO AL 8810 inhibits the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]] CTD PMID:33486071 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO fluprostenol inhibits the reaction [Niacin results in increased expression of PPARG mRNA] CTD PMID:21236357 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgfr prostaglandin F receptor multiple interactions ISO PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of GCLM mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of HMOX1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of NQO1 mRNA]]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]] CTD PMID:33486071 NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]; PTGFR protein affects the reaction [fluprostenol promotes the reaction [Oxidopamine results in increased expression of TXNRD1 mRNA]] CTD PMID:33486071 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        pharmacological role 19054
          agonist 18597
            prostaglandin receptor agonist 19
              fluprostenol 10
                travoprost 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      monocarboxylic acid 17966
                                        fatty acid 16685
                                          fatty acid derivative 8930
                                            icosanoid 468
                                              prostanoid 404
                                                prostaglandin 397
                                                  prostaglandins F 102
                                                    prostaglandins Falpha 101
                                                      fluprostenol 10
                                                        travoprost 0
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