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Accession:CHEBI:60782 term browser browse the term
Definition:An organofluorine compound that is racemic prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of its isopropyl ester prodrug, travoprost, are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. The isopropyl ester group of travoprost is hydrolysed to the biologically active free acid by esterases in the cornea.
Synonyms:exact_synonym: rac-(5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-en-1-yl}cyclopentyl]hept-5-enoic acid
 related_synonym: EINECS 255-029-3;   Formula=C23H29F3O6;   ICI 81,008;   InChI=1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1;   InChIKey=WWSWYXNVCBLWNZ-QIZQQNKQSA-N;   SMILES=O[C@@H](COc1cccc(c1)C(F)(F)F)\\C=C\\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O;   fluprostenolum;   travoprost acid;   travoprost free acid
 xref: CAS:40666-16-8 "ChemIDplus"
 xref_mesh: MESH:C006326
 xref: PMID:11832489 "Europe PMC";   PMID:11929662 "Europe PMC";   PMID:550147 "Europe PMC";   PMID:6090118 "Europe PMC";   PMID:6911921 "Europe PMC";   PMID:6916556 "Europe PMC";   PMID:941381 "Europe PMC";   PMID:951924 "Europe PMC";   Reaxys:8368795 "Reaxys"

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fluprostenol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fabp4 fatty acid binding protein 4 JBrowse link 2 93,792,666 93,797,267 RGD:6480464
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          agonist 18015
            prostaglandin receptor agonist 3
              fluprostenol 3
                travoprost 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          fatty acid 15814
                                            fatty acid derivative 1008
                                              icosanoid 450
                                                prostanoid 393
                                                  prostaglandin 388
                                                    prostaglandins F 97
                                                      prostaglandins Falpha 96
                                                        fluprostenol 3
                                                          travoprost 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.