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ONTOLOGY REPORT - ANNOTATIONS


Term:ivermectin
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Accession:CHEBI:6078 term browser browse the term
Definition:A mixture consisting of >= 90% 22,23-dihydroavermectin B1a (R = Me) and <= 10% 22,23-dihydroavermectin B1b (R = H). A semi-synthetic derivative of abamectin, it is used as a broad-spectrum antiparasite medication, particularly against worms (except tapeworms), although it is also effective against most mites and some lice.
Synonyms:related_synonym: Formula=C47H71O14R;   Ivermax;   Ivomec;   Mectizan;   Noromectin;   Privermectin;   SMILES=[H][C@@]12C\\C=C(C)\\[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)\\C=C\\C=C3/CO[C@]4([H])[C@H](O)C(C)=C[C@@]([H])(C(=O)O[C@@H](C1)C[C@]1(CC[C@H](C)[C@]([H])(O1)[C@@H](C)C[*])O2)[C@]34O;   Sklice;   Stromectol;   Vetrimec;   Zimecterin;   ivermectine;   ivermectino;   ivermectinum
 xref: CAS:70288-86-7 "ChemIDplus";   CAS:70288-86-7 "KEGG COMPOUND";   DrugBank:DB00602;   HMDB:HMDB0014740;   KEGG:D00804
 xref_mesh: MESH:D007559
 xref: PMID:15078277 "Europe PMC";   PMID:18718154 "Europe PMC";   PMID:21824728 "Europe PMC";   PMID:21831526 "Europe PMC";   PMID:22039784 "Europe PMC";   PMID:22039801 "Europe PMC";   PMID:22047763 "Europe PMC";   Patent:US4199569;   Wikipedia:Ivermectin


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ivermectin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A JBrowse link 5 8,567,091 8,748,575 RGD:6480464
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B JBrowse link 5 8,798,147 8,866,314 RGD:6480464
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 JBrowse link 16 14,361,453 14,474,878 RGD:6480464
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 JBrowse link 19 43,782,308 43,838,332 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) JBrowse link 6 58,584,491 58,692,451 RGD:6480464
G Acaca acetyl-Coenzyme A carboxylase alpha JBrowse link 11 84,129,635 84,401,651 RGD:6480464
G Adcy7 adenylate cyclase 7 JBrowse link 8 88,272,190 88,329,965 RGD:6480464
G Adm adrenomedullin JBrowse link 7 110,627,657 110,629,820 RGD:6480464
G Aldh1l2 aldehyde dehydrogenase 1 family, member L2 JBrowse link 10 83,487,447 83,534,146 RGD:6480464
G Angptl6 angiopoietin-like 6 JBrowse link 9 20,873,808 20,879,822 RGD:6480464
G Arl4c ADP-ribosylation factor-like 4C JBrowse link 1 88,698,225 88,702,191 RGD:6480464
G Atf4 activating transcription factor 4 JBrowse link 15 80,255,184 80,257,545 RGD:6480464
G Atf5 activating transcription factor 5 JBrowse link 7 44,812,256 44,816,658 RGD:6480464
G Atf6 activating transcription factor 6 JBrowse link 1 170,704,457 170,868,585 RGD:6480464
G Bag3 BCL2-associated athanogene 3 JBrowse link 7 128,523,583 128,546,981 RGD:6480464
G Bax BCL2-associated X protein JBrowse link 7 45,461,695 45,466,903 RGD:6480464
G Bbc3 BCL2 binding component 3 JBrowse link 7 16,308,398 16,318,334 RGD:6480464
G Bnip3 BCL2/adenovirus E1B interacting protein 3 JBrowse link 7 138,890,836 138,909,506 RGD:6480464
G Camp cathelicidin antimicrobial peptide JBrowse link 9 109,847,377 109,849,456 RGD:6480464
G Cat catalase JBrowse link 2 103,453,904 103,485,153 RGD:6480464
G Ccl3 chemokine (C-C motif) ligand 3 JBrowse link 11 83,647,843 83,649,378 RGD:6480464
G Ccr7 chemokine (C-C motif) receptor 7 JBrowse link 11 99,144,199 99,155,077 RGD:6480464
G Cct3 chaperonin containing Tcp1, subunit 3 (gamma) JBrowse link 3 88,297,135 88,321,766 RGD:6480464
G Cd36 CD36 molecule JBrowse link 5 17,781,690 17,888,959 RGD:6480464
G Cdh1 cadherin 1 JBrowse link 8 106,603,350 106,670,247 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) JBrowse link 17 29,090,979 29,100,722 RGD:6480464
G Cdkn1b cyclin-dependent kinase inhibitor 1B JBrowse link 6 134,920,401 134,925,525 RGD:6480464
G Cebpa CCAAT/enhancer binding protein (C/EBP), alpha JBrowse link 7 35,119,293 35,121,928 RGD:6480464
G Cox6a2 cytochrome c oxidase subunit 6A2 JBrowse link 7 128,205,435 128,206,366 RGD:6480464
G Cpt1a carnitine palmitoyltransferase 1a, liver JBrowse link 19 3,322,326 3,385,735 RGD:6480464
G Crp C-reactive protein, pentraxin-related JBrowse link 1 172,698,056 172,699,966 RGD:6480464
G Ctsl cathepsin L JBrowse link 13 64,361,890 64,370,772 RGD:6480464
G Cxcl15 chemokine (C-X-C motif) ligand 15 JBrowse link 5 90,794,534 90,803,067 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 9 57,687,928 57,703,824 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 9 57,676,937 57,683,655 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 17 79,706,940 79,715,061 RGD:6480464
G Cyp2a4 cytochrome P450, family 2, subfamily a, polypeptide 4 JBrowse link 7 26,307,192 26,315,088 RGD:6480464
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 JBrowse link 7 25,897,658 25,926,624 RGD:6480464
G Cyp2c29 cytochrome P450, family 2, subfamily c, polypeptide 29 JBrowse link 19 39,287,044 39,330,713 RGD:6480464
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 JBrowse link 19 39,061,006 39,093,948 RGD:6480464
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 JBrowse link 19 39,113,898 39,186,756 RGD:6480464
G Cyp2d22 cytochrome P450, family 2, subfamily d, polypeptide 22 JBrowse link 15 82,370,527 82,380,260 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 7 140,763,819 140,774,990 RGD:6480464
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 JBrowse link 5 145,854,607 145,879,854 RGD:6480464
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 10 127,290,793 127,296,291 RGD:6480464
G Dnajb1 DnaJ heat shock protein family (Hsp40) member B1 JBrowse link 8 83,608,175 83,612,653 RGD:6480464
G Dpysl2 dihydropyrimidinase-like 2 JBrowse link 14 66,802,864 66,911,156 RGD:6480464
G Edem1 ER degradation enhancer, mannosidase alpha-like 1 JBrowse link 6 108,824,045 108,859,356 RGD:6480464
G Edn1 endothelin 1 JBrowse link 13 42,301,476 42,307,990 RGD:6480464
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 12 54,178,981 54,203,874 RGD:6480464
G Esr1 estrogen receptor 1 (alpha) JBrowse link 10 4,611,989 5,005,633 RGD:6480464
G Fabp4 fatty acid binding protein 4, adipocyte JBrowse link 3 10,204,342 10,208,616 RGD:6480464
G Fasn fatty acid synthase JBrowse link 11 120,805,958 120,825,166 RGD:6480464
G Gdf15 growth differentiation factor 15 JBrowse link 8 70,629,393 70,632,470 RGD:6480464
G Gem GTP binding protein (gene overexpressed in skeletal muscle) JBrowse link 4 11,704,447 11,714,993 RGD:6480464
G Glra1 glycine receptor, alpha 1 subunit JBrowse link 11 55,514,239 55,608,198 RGD:6480464
G Glra3 glycine receptor, alpha 3 subunit JBrowse link 8 55,940,418 56,130,070 RGD:6480464
G Glrb glycine receptor, beta subunit JBrowse link 3 80,843,598 80,913,660 RGD:6480464
G Gpr183 G protein-coupled receptor 183 JBrowse link 14 121,952,331 121,965,193 RGD:6480464
G Hsp90aa1 heat shock protein 90, alpha (cytosolic), class A member 1 JBrowse link 12 110,691,036 110,696,395 RGD:6480464
G Hsp90ab1 heat shock protein 90 alpha (cytosolic), class B member 1 JBrowse link 17 45,567,778 45,573,261 RGD:6480464
G Hspa1a heat shock protein 1A JBrowse link 17 34,969,359 34,972,156 RGD:6480464
G Hspa4 heat shock protein 4 JBrowse link 11 53,259,814 53,300,479 RGD:6480464
G Hspa5 heat shock protein 5 JBrowse link 2 34,772,090 34,776,529 RGD:6480464
G Hspa8 heat shock protein 8 JBrowse link 9 40,801,276 40,805,202 RGD:6480464
G Hspa9 heat shock protein 9 JBrowse link 18 34,937,414 34,954,351 RGD:6480464
G Hspd1 heat shock protein 1 (chaperonin) JBrowse link 1 55,077,833 55,088,243 RGD:6480464
G Hspe1 heat shock protein 1 (chaperonin 10) JBrowse link 1 55,088,148 55,091,317 RGD:6480464
G Hsph1 heat shock 105kDa/110kDa protein 1 JBrowse link 5 149,616,843 149,636,498 RGD:6480464
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 11 7,206,086 7,215,498 RGD:6480464
G Il10 interleukin 10 JBrowse link 1 131,019,845 131,024,970 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 2 129,299,609 129,310,186 RGD:6480464
G Il1r1 interleukin 1 receptor, type I JBrowse link 1 40,222,480 40,316,201 RGD:6480464
G Ins1 insulin I JBrowse link 19 52,264,297 52,265,015 RGD:6480464
G Lonp1 lon peptidase 1, mitochondrial JBrowse link 17 56,614,297 56,626,903 RGD:6480464
G Map3k8 mitogen-activated protein kinase kinase kinase 8 JBrowse link 18 4,331,325 4,352,953 RGD:6480464
G Mapk1 mitogen-activated protein kinase 1 JBrowse link 16 16,983,382 17,047,453 RGD:6480464
G Mapk3 mitogen-activated protein kinase 3 JBrowse link 7 126,759,626 126,765,816 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 14 33,377,898 33,447,353 RGD:6480464
G Mxd1 MAX dimerization protein 1 JBrowse link 6 86,647,044 86,669,234 RGD:6480464
G Nanog Nanog homeobox JBrowse link 6 122,707,489 122,714,633 RGD:6480464
G Ncoa2 nuclear receptor coactivator 2 JBrowse link 1 13,139,105 13,374,227 RGD:6480464
G Ndrg1 N-myc downstream regulated gene 1 JBrowse link 15 66,929,318 66,969,641 RGD:6480464
G Nos2 nitric oxide synthase 2, inducible JBrowse link 11 78,920,787 78,960,226 RGD:6480464
G Nppb natriuretic peptide type B JBrowse link 4 147,985,786 147,987,205 RGD:6480464
G Nqo1 NAD(P)H dehydrogenase, quinone 1 JBrowse link 8 107,388,225 107,403,205 RGD:6480464
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 10 89,454,234 89,533,645 RGD:6480464
G Nupr1 nuclear protein transcription regulator 1 JBrowse link 7 126,623,246 126,625,470 RGD:6480464
G P2rx4 purinergic receptor P2X, ligand-gated ion channel 4 JBrowse link 5 122,707,518 122,729,739 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase family, member 1 JBrowse link 1 180,568,891 180,600,999 RGD:6480464
G Pfkl phosphofructokinase, liver, B-type JBrowse link 10 77,986,947 78,009,807 RGD:6480464
G Pou5f1 POU domain, class 5, transcription factor 1 JBrowse link 17 35,506,032 35,510,777 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 15 85,734,910 85,806,851 RGD:6480464
G Pparg peroxisome proliferator activated receptor gamma JBrowse link 6 115,360,879 115,490,404 RGD:6480464
G Ppid peptidylprolyl isomerase D (cyclophilin D) JBrowse link 3 79,591,337 79,603,810 RGD:6480464
G Ppif peptidylprolyl isomerase F (cyclophilin F) JBrowse link 14 25,693,574 25,700,468 RGD:6480464
G Ptges3 prostaglandin E synthase 3 JBrowse link 10 128,058,982 128,077,254 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 1 150,100,031 150,108,234 RGD:6480464
G Rpp14 ribonuclease P 14 subunit JBrowse link 14 8,080,313 8,091,846 RGD:6480464
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 JBrowse link 5 137,061,504 137,072,272 RGD:6480464
G Sin3a transcriptional regulator, SIN3A (yeast) JBrowse link 9 57,071,991 57,128,368 RGD:6480464
G Skap2 src family associated phosphoprotein 2 JBrowse link 6 51,859,165 52,012,549 RGD:6480464
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 JBrowse link 4 119,108,745 119,137,330 RGD:6480464
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 JBrowse link 11 69,942,286 69,948,216 RGD:6480464
G Sox2 SRY (sex determining region Y)-box 2 JBrowse link 3 34,649,995 34,652,461 RGD:6480464
G Sphk1 sphingosine kinase 1 JBrowse link 11 116,530,836 116,536,675 RGD:6480464
G St13 suppression of tumorigenicity 13 JBrowse link 15 81,365,044 81,399,694 RGD:6480464
G Tcp1 t-complex protein 1 JBrowse link 17 12,916,329 12,925,067 RGD:6480464
G Tfrc transferrin receptor JBrowse link 16 32,608,896 32,632,794 RGD:6480464
G Tgif1 TGFB-induced factor homeobox 1 JBrowse link 17 70,844,205 70,853,532 RGD:6480464
G Tlr2 toll-like receptor 2 JBrowse link 3 83,836,272 83,841,824 RGD:6480464
G Tlr4 toll-like receptor 4 JBrowse link 4 66,827,551 66,846,581 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 17 35,199,367 35,202,007 RGD:6480464
G Trib3 tribbles pseudokinase 3 JBrowse link 2 152,337,425 152,344,060 RGD:6480464
G Trp53 transformation related protein 53 JBrowse link 11 69,580,348 69,591,873 RGD:6480464
G Tsc22d1 TSC22 domain family, member 1 JBrowse link 14 76,414,961 76,507,765 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21263
    chemical entity 21261
      chemical substance 11558
        mixture 10844
          ivermectin 116
Path 2
Term Annotations click to browse term
  CHEBI ontology 21263
    subatomic particle 21259
      composite particle 21259
        hadron 21259
          baryon 21259
            nucleon 21259
              atomic nucleus 21259
                atom 21259
                  main group element atom 21127
                    p-block element atom 21127
                      carbon group element atom 20900
                        carbon atom 20790
                          organic molecular entity 20790
                            organic group 19182
                              organic divalent group 19172
                                organodiyl group 19172
                                  carbonyl group 19144
                                    carbonyl compound 19144
                                      carboxylic ester 14282
                                        lactone 5943
                                          macrocyclic lactone 1572
                                            macrolide 1512
                                              avermectin 122
                                                avermectin B1a 121
                                                  22,23-dihydroavermectin B1a 116
                                                    ivermectin 116
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.