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ONTOLOGY REPORT - ANNOTATIONS


Term:floxuridine
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Accession:CHEBI:60761 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Synonyms:related_synonym: 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil;   1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil;   1beta-D-2'-Deoxyribofuranosyl-5-flurouracil;   2'-Deoxy-5-fluorouridine;   5-Fluoro-2-desoxyuridine;   5-Fluorodeoxyuridine;   5-Fluorouracil 2'-deoxyriboside;   5-Fluorouracil deoxyriboside;   5-fluoro-2'-deoxyuridine;   5FDU;   Deoxyfluorouridine;   FdU;   Floxuridin;   Fluorodeoxyuridine;   Fluoruridine Deoxyribose;   Formula=C9H11FN2O5;   InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1;   InChIKey=ODKNJVUHOIMIIZ-RRKCRQDMSA-N;   SMILES=OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O;   beta-5-Fluoro-2'-deoxyuridine;   floxiridina;   floxuridinum
 xref: CAS:50-91-9;   DrugBank:DB00322;   Drug_Central:1184;   HMDB:HMDB0014467;   KEGG:C11736;   KEGG:D04197;   LINCS:LSM-5588
 xref_mesh: MESH:D005467
 xref: PMID:12520460;   PMID:19744858;   PMID:19917528;   PMID:20218622;   PMID:20363130;   PMID:20391188;   PMID:28166217;   PMID:29438107;   PMID:3950402;   Reaxys:90221;   Wikipedia:Floxuridine


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floxuridine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Atr ATR serine/threonine kinase JBrowse link 8 103,673,578 103,770,886 RGD:6480464
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:6480464
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:6480464
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:6480464
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:6480464
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:6480464
G Tk1 thymidine kinase 1 JBrowse link 10 106,817,556 106,828,888 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464
G Ung uracil-DNA glycosylase JBrowse link 12 48,246,593 48,255,547 RGD:6480464
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:6480464
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      biological role 19737
        biochemical role 19232
          antimetabolite 8497
            floxuridine 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19158
                              organochalcogen compound 18859
                                organooxygen compound 18776
                                  carbohydrates and carbohydrate derivatives 12164
                                    carbohydrate 12164
                                      carbohydrate derivative 11789
                                        glycosyl compound 10825
                                          N-glycosyl compound 5325
                                            nucleoside 5188
                                              deoxyribonucleoside 2716
                                                2'-deoxyribonucleoside 2198
                                                  pyrimidine 2'-deoxyribonucleoside 337
                                                    floxuridine 16
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