Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:floxuridine
go back to main search page
Accession:CHEBI:60761 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Synonyms:related_synonym: 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil;   1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil;   1beta-D-2'-Deoxyribofuranosyl-5-flurouracil;   2'-Deoxy-5-fluorouridine;   5-Fluoro-2-desoxyuridine;   5-Fluorodeoxyuridine;   5-Fluorouracil 2'-deoxyriboside;   5-Fluorouracil deoxyriboside;   5-fluoro-2'-deoxyuridine;   5FDU;   Deoxyfluorouridine;   FdU;   Floxuridin;   Fluorodeoxyuridine;   Fluoruridine deoxyribose;   beta-5-Fluoro-2'-deoxyuridine;   floxiridina;   floxuridinum
 xref: CAS:50-91-9;   DrugBank:DB00322;   HMDB:HMDB0014467
 xref_mesh: MESH:D005467
 xref: Reaxys:90221;   drugcentral:1184;   kegg.compound:C11736;   kegg.drug:D04197;   lincs.smallmolecule:LSM-5588;   pubmed:12520460;   pubmed:19744858;   pubmed:19917528;   pubmed:20218622;   pubmed:20363130;   pubmed:20391188;   pubmed:28166217;   pubmed:29438107;   pubmed:3950402;   wikipedia.en:Floxuridine
 chemrof_formula: C9H11FN2O5
 chemrof_inchi: InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
 chemrof_smiles: O=c1nc(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1F
 chemrof_inchikey: ODKNJVUHOIMIIZ-RRKCRQDMSA-N


show annotations for term's descendants           Sort by:
floxuridine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases response to substance
decreases response to substance 		ISO APEX1 protein mutant form results in increased susceptibility to Floxuridine
APEX1 protein results in decreased susceptibility to Floxuridine 		CTD PMID:19470598 PMID:22194930 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329 		JBrowse link
G Atr ATR serine/threonine kinase decreases response to substance ISO ATR protein results in decreased susceptibility to Floxuridine CTD PMID:21613406 PMID:22194930 NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:105,306,305...105,403,718 		JBrowse link
G C1qbp complement C1q binding protein decreases response to substance ISO C1QBP protein results in decreased susceptibility to Floxuridine CTD PMID:25354864 NCBI chr10:56,198,534...56,203,185
Ensembl chr10:56,198,540...56,203,235 		JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO Floxuridine results in increased phosphorylation of and results in increased activity of CHEK1 protein CTD PMID:21613406 PMID:22194930 NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:44,609,417...44,629,359 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases activity 		ISO Floxuridine results in increased phosphorylation of and results in increased activity of CHEK2 protein
Floxuridine results in increased activity of CHEK2 protein 		CTD PMID:21613406 PMID:22194930 NCBI chr12:51,448,838...51,481,159
Ensembl chr12:51,449,140...51,480,667 		JBrowse link
G Mlh1 mutL homolog 1 multiple interactions
decreases response to substance 		ISO olaparib inhibits the reaction [MLH1 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr 8:120,074,871...120,112,109
Ensembl chr 8:120,065,900...120,112,011 		JBrowse link
G Msh2 mutS homolog 2 multiple interactions
decreases response to substance 		ISO olaparib inhibits the reaction [MSH2 protein results in decreased susceptibility to Floxuridine] CTD PMID:22194930 NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:12,567,368...12,626,503 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase affects response to substance ISO MTHFR protein affects the susceptibility to Floxuridine CTD PMID:18202788 NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:163,748,321...163,768,105 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases response to substance ISO PARP1 protein results in decreased susceptibility to Floxuridine CTD PMID:21613406 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567 		JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 affects response to substance
decreases response to substance 		ISO TIMP3 protein affects the susceptibility to Floxuridine
TIMP3 gene modified form results in decreased susceptibility to Floxuridine 		CTD PMID:18202788 NCBI chr 7:19,408,539...19,459,558
Ensembl chr 7:19,409,631...19,459,547 		JBrowse link
G Tk1 thymidine kinase 1 increases expression ISO Floxuridine results in increased expression of TK1 protein CTD PMID:16951200 NCBI chr10:103,533,449...103,544,818
Ensembl chr10:103,533,449...103,556,228 		JBrowse link
G Tp53 tumor protein p53 increases expression
affects activity 		ISO Floxuridine results in increased expression of TP53 protein
Floxuridine affects the activity of TP53 protein 		CTD PMID:19015155 PMID:35435491 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299 		JBrowse link
G Tyms thymidylate synthetase affects response to substance
decreases response to substance
increases response to substance 		ISO TYMS protein affects the susceptibility to Floxuridine
TYMS protein results in decreased susceptibility to Floxuridine
TYMS results in increased susceptibility to Floxuridine 		CTD PMID:2537495 PMID:10482907 PMID:15040806 PMID:17018589 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097 		JBrowse link
G Ung uracil-DNA glycosylase affects expression
affects stability
increases response to substance 		ISO Floxuridine affects the expression of UNG mRNA; Floxuridine affects the expression of UNG protein
Floxuridine affects the stability of UNG protein alternative form
UNG protein results in increased susceptibility to Floxuridine 		CTD PMID:16951200 NCBI chr12:48,145,838...48,154,789
Ensembl chr12:48,145,838...48,155,257 		JBrowse link
G Xrcc1 X-ray repair cross complementing 1 decreases response to substance ISO XRCC1 protein results in decreased susceptibility to Floxuridine CTD PMID:21613406 PMID:22194930 NCBI chr 1:89,268,721...89,296,619
Ensembl chr 1:89,268,644...89,296,613 		JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases response to substance ISO XRCC4 results in decreased susceptibility to Floxuridine CTD PMID:21785230 NCBI chr 2:22,686,506...22,932,929
Ensembl chr 2:22,686,508...22,933,160 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    role 20844
      biological role 20831
        biochemical role 19888
          antimetabolite 10500
            floxuridine 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      carbon group element atom 20712
                        carbon atom 20706
                          organic molecular entity 20706
                            heteroorganic entity 20201
                              organochalcogen compound 19822
                                organooxygen compound 19713
                                  carbohydrates and carbohydrate derivatives 15263
                                    carbohydrate derivative 14522
                                      glycosyl compound 13128
                                        N-glycosyl compound 5000
                                          nucleoside 4662
                                            deoxyribonucleoside 2901
                                              2'-deoxyribonucleoside 2259
                                                pyrimidine 2'-deoxyribonucleoside 364
                                                  floxuridine 16
paths to the root