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ONTOLOGY REPORT - ANNOTATIONS


Term:floxuridine
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Accession:CHEBI:60761 term browser browse the term
Definition:A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Synonyms:related_synonym: 1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil;   1-beta-D-2'-Deoxyribofuranosyl-5-flurouracil;   1beta-D-2'-Deoxyribofuranosyl-5-flurouracil;   2'-Deoxy-5-fluorouridine;   5-Fluoro-2-desoxyuridine;   5-Fluorodeoxyuridine;   5-Fluorouracil 2'-deoxyriboside;   5-Fluorouracil deoxyriboside;   5-fluoro-2'-deoxyuridine;   5FDU;   Deoxyfluorouridine;   FdU;   Floxuridin;   Fluorodeoxyuridine;   Fluoruridine Deoxyribose;   Formula=C9H11FN2O5;   InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1;   InChIKey=ODKNJVUHOIMIIZ-RRKCRQDMSA-N;   SMILES=OC[C@H]1O[C@H](C[C@@H]1O)n1cc(F)c(=O)[nH]c1=O;   beta-5-Fluoro-2'-deoxyuridine;   floxiridina;   floxuridinum
 xref: CAS:50-91-9 "ChemIDplus";   CAS:50-91-9 "KEGG COMPOUND";   CAS:50-91-9 "KEGG DRUG";   CAS:50-91-9 "NIST Chemistry WebBook";   DrugBank:DB00322;   Drug_Central:1184 "DrugCentral";   HMDB:HMDB0014467;   KEGG:C11736;   KEGG:D04197;   LINCS:LSM-5588
 xref_mesh: MESH:D005467
 xref: PMID:12520460 "Europe PMC";   PMID:19744858 "Europe PMC";   PMID:19917528 "Europe PMC";   PMID:20218622 "Europe PMC";   PMID:20363130 "Europe PMC";   PMID:20391188 "Europe PMC";   PMID:28166217 "Europe PMC";   PMID:29438107 "Europe PMC";   PMID:3950402 "Europe PMC";   Reaxys:90221 "Reaxys";   Wikipedia:Floxuridine


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floxuridine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Atr ATR serine/threonine kinase JBrowse link 8 103,673,578 103,770,886 RGD:6480464
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:6480464
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:6480464
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:6480464
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:6480464
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:6480464
G Mthfr methylenetetrahydrofolate reductase JBrowse link 5 164,844,642 164,864,360 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Timp3 TIMP metallopeptidase inhibitor 3 JBrowse link 7 23,543,125 23,594,170 RGD:6480464
G Tk1 thymidine kinase 1 JBrowse link 10 106,817,556 106,828,888 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tyms thymidylate synthetase JBrowse link 9 121,918,875 121,931,564 RGD:6480464
G Ung uracil-DNA glycosylase JBrowse link 12 48,246,593 48,255,547 RGD:6480464
G Xrcc1 X-ray repair cross complementing 1 JBrowse link 1 81,412,635 81,441,680 RGD:6480464
G Xrcc4 X-ray repair cross complementing 4 JBrowse link 2 18,674,496 18,927,463 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19614
    role 19557
      biological role 19550
        biochemical role 19057
          antimetabolite 8471
            floxuridine 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    p-block element atom 19489
                      carbon group element atom 19362
                        carbon atom 19354
                          organic molecular entity 19354
                            heteroorganic entity 18925
                              organochalcogen compound 18674
                                organooxygen compound 18582
                                  carbohydrates and carbohydrate derivatives 11697
                                    carbohydrate 11697
                                      carbohydrate derivative 11309
                                        glycosyl compound 10289
                                          N-glycosyl compound 4202
                                            nucleoside 4024
                                              deoxyribonucleoside 981
                                                2'-deoxyribonucleoside 309
                                                  pyrimidine 2'-deoxyribonucleoside 294
                                                    floxuridine 16
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.