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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:itraconazole
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Accession:CHEBI:6076 term browser browse the term
Definition:An N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis.
Synonyms:exact_synonym: 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
 related_synonym: Formula=C35H38Cl2N8O4;   InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1;   InChIKey=VHVPQPYKVGDNFY-ZPGVKDDISA-N;   Itrizole (TN);   Oriconazole;   SMILES=CCC(C)n1ncn(-c2ccc(cc2)N2CCN(CC2)c2ccc(OC[C@H]3CO[C@@](Cn4cncn4)(O3)c3ccc(Cl)cc3Cl)cc2)c1=O;   Sporanox (TN)
 xref: CAS:84625-61-6;   DrugBank:DB01167;   KEGG:D00350
 xref_mesh: MESH:D017964
 xref: PMID:11219548;   PMID:11403818;   PMID:11422002;   PMID:15521894;   PMID:19025521;   PMID:20400651;   PMID:25326091;   Patent:EP6711;   Patent:US4267179;   VSDB:1853;   Wikipedia:Itraconazole



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itraconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Itraconazole results in decreased activity of ABCB11 protein CTD PMID:20829430 PMID:23956101 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects activity
decreases activity
multiple interactions
affects transport
ISO Itraconazole affects the activity of ABCB1 protein
Itraconazole results in decreased activity of ABCB1 protein
Itraconazole inhibits the reaction [ABCB1 protein affects the transport of Digoxin]; Itraconazole promotes the reaction [ABCB1 gene SNP affects the susceptibility to fexofenadine]
ABCB1 protein affects the transport of Itraconazole
CTD PMID:15905803 PMID:15964336 PMID:15969931 PMID:16084853 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acvr1c activin A receptor type 1C increases expression ISO Itraconazole results in increased expression of ACVR1C mRNA CTD PMID:31099283 NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:42,822,610...42,892,327
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein] CTD PMID:17923278 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Amdhd1 amidohydrolase domain containing 1 decreases expression ISO Itraconazole results in decreased expression of AMDHD1 mRNA CTD PMID:31099283 NCBI chr 7:28,043,923...28,059,156
Ensembl chr 7:28,043,716...28,059,156
JBrowse link
G Ar androgen receptor multiple interactions ISO Itraconazole binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bicc1 BicC family RNA binding protein 1 decreases expression ISO Itraconazole results in decreased expression of BICC1 mRNA CTD PMID:31099283 NCBI chr20:17,449,639...17,686,775
Ensembl chr20:17,449,560...17,686,776
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cpn2 carboxypeptidase N subunit 2 decreases expression ISO Itraconazole results in decreased expression of CPN2 mRNA CTD PMID:31099283 NCBI chr11:70,486,054...70,495,937
Ensembl chr11:70,486,057...70,496,472
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; Itraconazole inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression ISO Itraconazole results in increased expression of CXCL1 mRNA CTD PMID:31099283 NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO Itraconazole binds to and results in decreased activity of CYP11B1 protein CTD PMID:31982514 NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 multiple interactions ISO Itraconazole binds to and results in decreased activity of CYP11B2 protein CTD PMID:31982514 NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
decreases activity
ISO Dactinomycin inhibits the reaction [Itraconazole results in increased expression of CYP1A1 mRNA]; Itraconazole results in increased expression of and results in increased activity of CYP1A1 protein
Itraconazole results in increased expression of CYP1A1 mRNA; Itraconazole results in increased expression of CYP1A1 protein
Itraconazole results in decreased activity of CYP1A1 protein
CTD PMID:17283379 PMID:28390928 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp24a1 cytochrome P450, family 24, subfamily a, polypeptide 1 decreases activity ISO
EXP
Itraconazole results in decreased activity of CYP24A1 protein CTD PMID:15328084 NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases hydroxylation
affects activity
decreases activity
affects metabolic processing
increases metabolic processing
decreases expression
ISO Itraconazole binds to and results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased hydroxylation of Itraconazole
Itraconazole affects the activity of CYP3A4 protein
Itraconazole results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Itraconazole
CYP3A4 protein results in increased metabolism of Itraconazole
Itraconazole results in decreased expression of CYP3A4 mRNA; Itraconazole results in decreased expression of CYP3A4 protein
CTD PMID:15328084 PMID:15383492 PMID:15447735 PMID:15684493 PMID:15784650 More... NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp51 cytochrome P450, family 51 decreases activity
decreases response to substance
multiple interactions
ISO Itraconazole results in decreased activity of CYP51A1 protein
CYP51A1 gene results in decreased susceptibility to Itraconazole
CYP51A1 gene inhibits the reaction [Itraconazole results in decreased chemical synthesis of Ergosterol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of 14-methylergosta-8,24(28)-dien-3,6-diol]; CYP51A1 gene inhibits the reaction [Itraconazole results in decreased metabolism of and results in increased abundance of Lanosterol]
CTD PMID:16989930 PMID:18694951 NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410
JBrowse link
G Dclre1c DNA cross-link repair 1C increases expression ISO Itraconazole results in increased expression of DCLRE1C mRNA CTD PMID:31099283 NCBI chr17:79,684,988...79,718,399
Ensembl chr17:74,776,935...74,809,186
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Itraconazole results in increased expression of DDIT3 mRNA CTD PMID:31099283 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dtna dystrobrevin, alpha decreases expression ISO Itraconazole results in decreased expression of DTNA mRNA CTD PMID:31099283 NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 decreases expression ISO Itraconazole results in decreased expression of ENPP3 mRNA CTD PMID:31099283 NCBI chr 1:22,382,717...22,454,324
Ensembl chr 1:20,563,697...20,635,041
JBrowse link
G Esco2 establishment of sister chromatid cohesion N-acetyltransferase 2 decreases expression ISO Itraconazole results in decreased expression of ESCO2 mRNA CTD PMID:31099283 NCBI chr15:44,210,124...44,230,785
Ensembl chr15:40,034,568...40,055,306
Ensembl chr15:40,034,568...40,055,306
JBrowse link
G Esrra estrogen related receptor, alpha decreases expression ISO Itraconazole results in decreased expression of ESRRA mRNA CTD PMID:31099283 NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO Itraconazole results in increased expression of FABP5 mRNA CTD PMID:31099283 NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Itraconazole results in increased expression of FOSL1 mRNA CTD PMID:31099283 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Gfpt1 glutamine fructose-6-phosphate transaminase 1 decreases expression ISO Itraconazole results in decreased expression of GFPT1 mRNA CTD PMID:31099283 NCBI chr 4:121,054,023...121,103,799
Ensembl chr 4:119,496,714...119,546,471
JBrowse link
G Gjb1 gap junction protein, beta 1 decreases expression ISO Itraconazole results in decreased expression of GJB1 mRNA CTD PMID:31099283 NCBI chr  X:70,541,845...70,549,776
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO
EXP
Itraconazole analog results in decreased expression of GLI1 mRNA; Itraconazole results in decreased expression of GLI1 mRNA CTD PMID:21936514 PMID:33905526 NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Itraconazole results in increased expression of GOT1 protein CTD PMID:31099283 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpr6 G protein-coupled receptor 6 decreases expression ISO Itraconazole results in decreased expression of GPR6 mRNA CTD PMID:31099283 NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Itraconazole results in increased expression of GPT protein CTD PMID:31099283 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Itraconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gulp1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO Itraconazole results in decreased expression of GULP1 mRNA CTD PMID:31099283 NCBI chr 9:54,114,823...54,391,058
Ensembl chr 9:46,622,669...46,899,005
JBrowse link
G Hmga2 high mobility group AT-hook 2 increases expression ISO Itraconazole results in increased expression of HMGA2 mRNA CTD PMID:31099283 NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:55,880,112...55,994,784
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Itraconazole results in increased expression of HMGCS1 mRNA CTD PMID:31099283 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Itraconazole results in decreased expression of HMGCS2 mRNA CTD PMID:31099283 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:185,875,616...185,902,130
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Itraconazole results in decreased activity of HSD11B2 protein CTD PMID:28131847 PMID:29385285 PMID:33387577 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Ihh Indian hedgehog signaling molecule decreases expression EXP Itraconazole results in decreased expression of IHH mRNA CTD PMID:33905526 NCBI chr 9:83,952,986...83,959,203
Ensembl chr 9:76,504,315...76,510,532
JBrowse link
G Il12b interleukin 12B increases expression ISO Itraconazole results in increased expression of IL12B mRNA CTD PMID:31099283 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
decreases secretion
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL4 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL4 protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:11886533 PMID:15284827 PMID:23688403 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases secretion
decreases expression
ISO 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; 1-Methyl-3-isobutylxanthine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Bucladesine inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Bucladesine inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein]; Colforsin inhibits the reaction [Itraconazole results in decreased expression of IL5 mRNA]; Colforsin inhibits the reaction [Itraconazole results in decreased secretion of IL5 protein] CTD PMID:11886533 PMID:15284827 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Madcam1 mucosal vascular addressin cell adhesion molecule 1 multiple interactions ISO Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr 7:10,686,920...10,690,322
Ensembl chr 7:10,036,301...10,039,703
JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 increases expression ISO Itraconazole results in increased expression of MBD1 mRNA CTD PMID:31099283 NCBI chr18:70,145,093...70,159,744
Ensembl chr18:67,869,992...67,886,554
JBrowse link
G Myt1 myelin transcription factor 1 increases expression ISO Itraconazole results in increased expression of MYT1 mRNA CTD PMID:31099283 NCBI chr 3:189,263,569...189,327,844
Ensembl chr 3:168,886,089...168,950,341
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]] CTD PMID:17998298 NCBI chr 6:32,952,090...33,229,829
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO AHR promotes the reaction [Itraconazole results in increased expression of NQO1 mRNA]; AHR promotes the reaction [Itraconazole results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [Itraconazole results in increased expression of NQO1 mRNA]
Itraconazole results in increased expression of NQO1 mRNA; Itraconazole results in increased expression of NQO1 protein
CTD PMID:17923278 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases expression
ISO Itraconazole promotes the reaction [Rifampin promotes the reaction [NR1I2 protein binds to NCOA1 protein]]; Itraconazole promotes the reaction [Rifampin results in increased expression of NR1I2 mRNA]
Itraconazole results in increased expression of NR1I2 mRNA
CTD PMID:17998298 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Oaz3 ornithine decarboxylase antizyme 3 decreases expression ISO Itraconazole results in decreased expression of OAZ3 mRNA CTD PMID:31099283 NCBI chr 2:184,762,242...184,765,176
Ensembl chr 2:182,073,215...182,082,399
JBrowse link
G Pnma2 PNMA family member 2 increases expression ISO Itraconazole results in increased expression of PNMA2 mRNA CTD PMID:31099283 NCBI chr15:41,111,942...41,119,649
Ensembl chr15:41,112,009...41,121,427
JBrowse link
G Ptch1 patched 1 decreases expression EXP Itraconazole results in decreased expression of PTCH1 mRNA CTD PMID:33905526 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333
JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO Itraconazole results in decreased expression of RAPGEF4 mRNA CTD PMID:31099283 NCBI chr 3:77,217,024...77,509,933
Ensembl chr 3:56,809,270...57,102,316
JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression ISO Itraconazole results in decreased expression of RGS16 mRNA CTD PMID:31099283 NCBI chr13:68,421,480...68,443,312
Ensembl chr13:65,887,530...65,892,857
JBrowse link
G Rpp25 ribonuclease P and MRP subunit p25 increases expression ISO Itraconazole results in increased expression of RPP25 mRNA CTD PMID:31099283 NCBI chr 8:66,803,262...66,804,642
Ensembl chr 8:57,907,352...57,908,732
JBrowse link
G Sema3e semaphorin 3E increases expression ISO Itraconazole results in increased expression of SEMA3E mRNA CTD PMID:31099283 NCBI chr 4:21,252,686...21,510,449
Ensembl chr 4:20,299,718...20,555,229
JBrowse link
G Slc25a36 solute carrier family 25 member 36 increases expression ISO Itraconazole results in increased expression of SLC25A36 mRNA CTD PMID:31099283 NCBI chr 8:106,539,355...106,573,240
Ensembl chr 8:97,662,127...97,693,703
JBrowse link
G Smo smoothened, frizzled class receptor decreases expression EXP Itraconazole results in decreased expression of SMO mRNA CTD PMID:33905526 NCBI chr 4:59,311,084...59,341,280
Ensembl chr 4:58,343,529...58,373,829
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Itraconazole inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:24471457 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stx8 syntaxin 8 increases expression ISO Itraconazole results in increased expression of STX8 mRNA CTD PMID:31099283 NCBI chr10:53,154,572...53,393,912
Ensembl chr10:52,654,990...52,894,993
JBrowse link
G Sycp3 synaptonemal complex protein 3 increases expression ISO Itraconazole results in increased expression of SYCP3 mRNA CTD PMID:31099283 NCBI chr 7:24,761,476...24,775,933
Ensembl chr 7:22,874,055...22,888,511
JBrowse link
G Tbc1d9 TBC1 domain family member 9 increases expression ISO Itraconazole results in increased expression of TBC1D9 mRNA CTD PMID:31099283 NCBI chr19:41,746,732...41,855,924
Ensembl chr19:24,842,205...24,943,129
JBrowse link
G Tmem138 transmembrane protein 138 decreases expression ISO Itraconazole results in decreased expression of TMEM138 mRNA CTD PMID:31099283 NCBI chr 1:207,219,113...207,226,159 JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression ISO Itraconazole results in decreased expression of TMSB4X mRNA CTD PMID:31099283 NCBI chr  X:30,761,611...30,763,612
Ensembl chr  X:27,128,610...27,146,667
Ensembl chr10:27,128,610...27,146,667
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Itraconazole inhibits the reaction [TNF protein results in increased expression of MADCAM1 protein] CTD PMID:12388057 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Tspan8 tetraspanin 8 decreases expression ISO Itraconazole results in decreased expression of TSPAN8 mRNA CTD PMID:31099283 NCBI chr 7:51,444,946...51,479,360
Ensembl chr 7:51,445,074...51,479,356
JBrowse link
G Zfp451 zinc finger protein 451 increases expression ISO Itraconazole results in increased expression of ZFP451 mRNA CTD PMID:31099283 NCBI chr 9:43,481,395...43,546,103
Ensembl chr 9:35,985,443...36,040,652
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    role 19870
      biological role 19868
        inhibitor 18958
          enzyme inhibitor 18775
            pathway inhibitor 11769
              Hedgehog signaling pathway inhibitor 91
                itraconazole 67
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            organic molecule 19725
                              organic cyclic compound 19517
                                organic heterocyclic compound 18894
                                  heteroarene 17179
                                    monocyclic heteroarene 15026
                                      azole 14526
                                        triazoles 8446
                                          triazole antifungal agent 5763
                                            triazole antifungal drug 113
                                              itraconazole 67
paths to the root