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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Isradipine
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Accession:CHEBI:6073 term browser browse the term
Synonyms:related_synonym: DynaCirc (TN);   Formula=C19H21N3O5;   InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3;   InChIKey=HMJIYCCIJYRONP-UHFFFAOYSA-N;   SMILES=CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC;   dynacrine;   isradipin;   isrodipine
 alt_id: CHEBI:91953
 xref: CAS:75695-93-1;   Drug_Central:1511;   HMDB:HMDB0014415;   KEGG:D00349;   LINCS:LSM-1897
 xref_mesh: MESH:D017275


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Isradipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Isradipine results in decreased activity of ABCB11 protein
Isradipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Isradipine results in increased activity of AHR protein CTD PMID:27732883 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]; omega-conotoxin-MVIIC promotes the reaction [Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:11179973 NCBI chr13:71,899,445...72,534,992
Ensembl chr13:71,906,702...72,367,980
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F multiple interactions ISO Isradipine inhibits the reaction [CACNA1F protein results in increased transport of Barium] CTD PMID:14744918 NCBI chr  X:15,712,709...15,741,135
Ensembl chr  X:15,712,713...15,741,103
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Isradipine results in increased expression of CYP1A1 mRNA CTD PMID:27732883 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Isradipine results in increased expression of CYP1A2 mRNA CTD PMID:27732883 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Isradipine results in increased expression of CYP2B6 mRNA; Isradipine results in increased expression of CYP2B6 protein CTD PMID:27732883 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
affects metabolic processing
multiple interactions
ISO Isradipine results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of Isradipine
Isradipine results in increased expression of and results in decreased activity of CYP3A4 protein
CTD PMID:15286053 PMID:27732883 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Fgf2 fibroblast growth factor 2 increases secretion ISO Isradipine results in increased secretion of FGF2 protein CTD PMID:15257873 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,466,544...5,696,540
Ensembl chr 5:5,616,483...5,694,598
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Isradipine results in increased activity of NR1I2 protein CTD PMID:27732883 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Penk proenkephalin multiple interactions EXP Isradipine inhibits the reaction [Oxidopamine results in increased expression of PENK mRNA] CTD PMID:18947822 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Ren renin increases activity ISO Isradipine results in increased activity of REN protein CTD PMID:2550243 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Isradipine promotes the reaction [Cyclic AMP results in increased expression of STAR protein] CTD PMID:19822634 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        fuel 10826
          methanol 3079
            methyl ester 3068
              Isradipine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      chalcogen 19464
                        oxygen atom 19425
                          oxygen molecular entity 19425
                            hydroxides 19147
                              organic hydroxy compound 18696
                                alcohol 15040
                                  aliphatic alcohol 11155
                                    alkyl alcohol 11107
                                      methanol 3079
                                        methyl ester 3068
                                          Isradipine 15
paths to the root