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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Isradipine
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Accession:CHEBI:6073 term browser browse the term
Synonyms:related_synonym: DynaCirc (TN);   Formula=C19H21N3O5;   InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3;   InChIKey=HMJIYCCIJYRONP-UHFFFAOYSA-N;   SMILES=CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC;   dynacrine;   isradipin;   isrodipine
 alt_id: CHEBI:91953
 xref: CAS:75695-93-1;   Drug_Central:1511;   HMDB:HMDB0014415;   KEGG:D00349;   LINCS:LSM-1897
 xref_mesh: MESH:D017275



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Isradipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity
multiple interactions
ISO Isradipine results in decreased activity of ABCB11 protein
Isradipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
CTD PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Isradipine results in increased activity of AHR protein CTD PMID:27732883 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E multiple interactions EXP Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]; omega-conotoxin-MVIIC promotes the reaction [Isradipine inhibits the reaction [CACNA1E protein results in increased transport of Barium]] CTD PMID:11179973 NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450
JBrowse link
G Cacna1f calcium voltage-gated channel subunit alpha1 F multiple interactions ISO Isradipine inhibits the reaction [CACNA1F protein results in increased transport of Barium] CTD PMID:14744918 NCBI chr  X:14,868,096...14,896,413
Ensembl chr  X:14,868,024...14,896,413
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Isradipine results in increased expression of CYP1A1 mRNA CTD PMID:27732883 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO Isradipine results in increased expression of CYP1A2 mRNA CTD PMID:27732883 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO Isradipine results in increased expression of CYP2B6 mRNA; Isradipine results in increased expression of CYP2B6 protein CTD PMID:27732883 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
affects metabolic processing
ISO Isradipine results in increased expression of CYP3A4 mRNA
Isradipine results in increased expression of and results in decreased activity of CYP3A4 protein
CYP3A4 protein affects the metabolism of Isradipine
CTD PMID:15286053 PMID:27732883 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Fgf2 fibroblast growth factor 2 increases secretion ISO Isradipine results in increased secretion of FGF2 protein CTD PMID:15257873 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Ncoa2 nuclear receptor coactivator 2 multiple interactions ISO Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Isradipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]] CTD PMID:27773686 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Isradipine results in increased activity of NR1I2 protein CTD PMID:27732883 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Penk proenkephalin multiple interactions EXP Isradipine inhibits the reaction [Oxidopamine results in increased expression of PENK mRNA] CTD PMID:18947822 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Ren renin increases activity ISO Isradipine results in increased activity of REN protein CTD PMID:2550243 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Isradipine promotes the reaction [Cyclic AMP results in increased expression of STAR protein] CTD PMID:19822634 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        fuel 11112
          methanol 3865
            methyl ester 3836
              Isradipine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      chalcogen 19450
                        oxygen atom 19423
                          oxygen molecular entity 19423
                            hydroxides 19158
                              organic hydroxy compound 18656
                                alcohol 15085
                                  aliphatic alcohol 11331
                                    alkyl alcohol 11288
                                      methanol 3865
                                        methyl ester 3836
                                          Isradipine 15
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