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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:NMDA receptor antagonist
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Accession:CHEBI:60643 term browser browse the term
Definition:Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
Synonyms:related_synonym: N-methyl-D-aspartate receptor antagonist;   N-methyl-D-aspartate receptor antagonists;   NMDA receptor antagonists;   NMDAR antagonist;   NMDAR antagonists
 alt_id: CHEBI:60797


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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        pharmacological role 18825
          antagonist 16213
            excitatory amino acid antagonist 10112
              NMDA receptor antagonist 8632
                (1R,2S)-nortilidine + 0
                (R)-ketamine 0
                (R,R)-tramadol + 25
                (R,R)-tramadol hydrochloride + 0
                (S,S)-tramadol + 25
                (S,S)-tramadol hydrochloride + 0
                2-amino-5-phosphonopentanoic acid 1
                7-chlorokynurenic acid 1
                CGP 78608 0
                CGP 78608 hydrochloride 0
                amantadine 10
                amantadine hydrochloride 0
                amantadine sulfate 0
                dextromethorphan + 39
                dinitrogen oxide 8
                esketamine + 0
                esketamine hydrochloride 0
                ethanol + 8134
                ginsenoside Rb3 0
                isoliquiritigenin + 73
                ketamine + 820
                ketamine hydrochloride + 0
                kynurenic acid + 12
                memantine 17
                memantine hydrochloride 0
                noribogaine 0
                orphenadrine + 418
                orphenadrine citrate 0
                orphenadrine hydrochloride 0
                pentamidine 31
                phencyclidine 89
                rolicyclidine 0
                tenocyclidine 0
                tramadol 25
                tramadol hydrochloride 0
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