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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:opioid receptor antagonist
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Accession:CHEBI:60605 term browser browse the term
Definition:An agent that binds to but does not activate an opioid receptor thereby blocking the actions of endogenous or exogenous opioid receptor agonists.
Synonyms:related_synonym: opiate antagonist;   opiate antagonists;   opioid antagonist;   opioid antagonists;   opioid receptor antagonists
 xref: Wikipedia:Opioid_antagonist



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buprenorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor decreases expression EXP Buprenorphine results in decreased expression of BDNF protein CTD PMID:24321744 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Buprenorphine results in decreased activity of CAT protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein
CTD PMID:25683329 PMID:32113805 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of CREB1 protein CTD PMID:24321744 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing ISO CYP2C8 protein affects the metabolism of Buprenorphine CTD PMID:16010532
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
ISO CYP2D6 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP2D6 protein
CTD PMID:12756210 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
decreases alkylation
increases metabolic processing
decreases activity
ISO CYP3A4 protein affects the metabolism of Buprenorphine
CYP3A4 protein results in decreased alkylation of Buprenorphine
CYP3A4 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP3A4 protein
CTD PMID:12756210 PMID:15966752 PMID:16010532 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Buprenorphine results in increased activity of GPT protein CTD PMID:25683329 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Il2 interleukin 2 decreases expression ISO Buprenorphine results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 increases expression ISO Buprenorphine results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of NTRK2 protein CTD PMID:24321744 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRD1 protein
Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]
CTD PMID:7562497 PMID:21866885 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]
CTD PMID:7562497 PMID:21866885 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO Buprenorphine binds to and results in increased activity of OPRL1 protein CTD PMID:10998549 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
Buprenorphine binds to and affects the activity of OPRM1 protein; Buprenorphine binds to and results in increased activity of OPRM1 protein; Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]
Buprenorphine binds to OPRM1 protein
CTD PMID:7562497 PMID:16010532 PMID:21866885 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases activity EXP Buprenorphine results in decreased activity of PRKACA protein CTD PMID:24321744 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Buprenorphine CTD PMID:12756209 NCBI chr 9:88,801,344...88,808,465 JBrowse link
eluxadoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to eluxadoline CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
nalbuphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin increases expression ISO Nalbuphine results in increased expression of PRL protein CTD PMID:17391744 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nalbuphine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
naloxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
EXP Naloxone results in increased expression of ABCB1 mRNA
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA
CTD PMID:17522070 PMID:26554626 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Naloxone results in increased expression of ABCC3 mRNA CTD PMID:17522070 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acly ATP citrate lyase decreases expression EXP Naloxone results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Naloxone inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein] CTD PMID:17989109 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions EXP Naloxone promotes the reaction [AGT protein results in increased expression of CRH protein]; Naloxone promotes the reaction [AGT protein results in increased expression of FOS protein]; Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:33872574 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form] CTD PMID:20600172 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP Naloxone results in decreased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Avp arginine vasopressin decreases secretion ISO Naloxone results in decreased secretion of AVP protein CTD PMID:6850280 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]] CTD PMID:12927789 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]
Naloxone results in increased expression of BCL2 protein
CTD PMID:12927789 PMID:16004788 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity
multiple interactions
EXP Naloxone affects the activity of CALCA protein
Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]
CTD PMID:7906887 PMID:10075105 PMID:27030709 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form] CTD PMID:20600172 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase increases expression EXP Naloxone results in increased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cck cholecystokinin multiple interactions EXP Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine] CTD PMID:3561887 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:17084265 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
affects binding
ISO CES1 protein binds to and results in increased metabolism of Naloxone
Naloxone binds to CES1 protein
CTD PMID:12679808 PMID:12773168 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Crh corticotropin releasing hormone decreases expression
multiple interactions
EXP Naloxone results in decreased expression of CRH mRNA
Naloxone promotes the reaction [AGT protein results in increased expression of CRH protein]
CTD PMID:12431775 PMID:33872574 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions
increases response to substance
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Naloxone
CRHR1 gene mutant form results in increased susceptibility to Naloxone
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25582704 PMID:28434951 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
G Ctsl cathepsin L increases expression EXP Naloxone results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of DDB2] CTD PMID:19397953 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO [3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP] CTD PMID:15542745 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Naloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein] CTD PMID:26377394 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Naloxone results in decreased expression of FASN mRNA CTD PMID:17522070 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein] CTD PMID:20564181 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
[Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; Naloxone promotes the reaction [AGT protein results in increased expression of FOS protein]; Pentobarbital promotes the reaction [Naloxone results in increased expression of FOS protein]; SL 327 inhibits the reaction [Naloxone results in increased expression of FOS protein]
CTD PMID:9041360 PMID:15196794 PMID:16935424 PMID:17549049 PMID:22590628 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Naloxone results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form] CTD PMID:20600172 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Naloxone results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA] CTD PMID:15497504
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Naloxone results in increased expression of HSPA5 protein CTD PMID:26377394 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form] CTD PMID:10070497 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases response to substance ISO Naloxone results in increased susceptibility to IL1B protein CTD PMID:19458216 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases response to substance
ISO Freund's Adjuvant inhibits the reaction [Naloxone results in decreased susceptibility to IL2 protein] CTD PMID:12421473 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:17084265 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klf7 Kruppel like factor 7 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA] CTD PMID:14644156 NCBI chr 9:65,437,535...65,484,720
Ensembl chr 9:65,437,167...65,526,261
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Naloxone results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
JBrowse link
G Lgals3 galectin 3 increases expression EXP Naloxone results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
affects expression
multiple interactions
ISO
EXP
Naloxone results in increased expression of LHB protein
Naloxone affects the expression of LHB protein
Naloxone affects the expression of and affects the secretion of LHB protein
CTD PMID:1794335 PMID:2745936 PMID:2880862 PMID:7629406 PMID:15905218 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Naloxone results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G LOC367746 similar to Spindlin-like protein 2 (SPIN-2) decreases expression EXP Naloxone results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:17,190,371...17,192,351
Ensembl chr  X:17,180,474...17,192,351
JBrowse link
G Ltf lactotransferrin decreases activity EXP Naloxone results in decreased activity of LTF protein CTD PMID:14563657 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Naloxone results in increased phosphorylation of and results in increased activity of MAPK1 protein
Naloxone results in increased phosphorylation of MAPK1 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:17549049 PMID:21483469 PMID:24398105 PMID:33872574 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Naloxone results in increased phosphorylation of and results in increased activity of MAPK3 protein
Naloxone results in increased phosphorylation of MAPK3 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:17549049 PMID:21483469 PMID:24398105 PMID:33872574 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mir16 microRNA 16 increases expression EXP Naloxone results in increased expression of MIR16 mRNA CTD PMID:17522070 NCBI chr 2:153,245,349...153,245,443
Ensembl chr 2:153,245,349...153,245,443
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Naloxone results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:155,076,270...155,130,051
Ensembl chr 4:155,076,312...155,130,051
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Naloxone results in increased expression of MYC mRNA CTD PMID:17522070 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein] CTD PMID:20519536 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Naloxone results in decreased expression of NPPA protein CTD PMID:11311734 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Naloxone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Naloxone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]
Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
Naloxone binds to OPRM1 protein
[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to N(6)-cyclopentyladenosine; Cannabidiol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Dronabinol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Naloxone binds to and results in decreased activity of OPRM1 protein; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]
CTD PMID:1528399 PMID:1654493 PMID:7562497 PMID:8383026 PMID:8987795 More... NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Naloxone results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Naloxone results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases expression
ISO
EXP
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone; Naloxone binds to and results in increased activity of POMC protein alternative form
Naloxone results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
Naloxone results in increased expression of POMC protein alternative form
CTD PMID:2255747 PMID:2846107 PMID:3157294 PMID:6089027 PMID:24398105 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Prl prolactin affects expression
decreases expression
ISO
EXP
Naloxone affects the expression of PRL protein
Naloxone results in decreased expression of PRL protein
CTD PMID:1794335 PMID:7629406 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptma prothymosin alpha decreases expression EXP Naloxone results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333
JBrowse link
G Ren renin increases activity ISO Naloxone results in increased activity of REN protein CTD PMID:3157294 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Sell selectin L multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form] CTD PMID:10070497 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]] CTD PMID:11723065 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Naloxone inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Naloxone inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein] CTD PMID:22825003 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Naloxone results in decreased expression of SREBF1 mRNA CTD PMID:17522070 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein] CTD PMID:11976266 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases phosphorylation
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25308750 PMID:25582704 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Naloxone results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Naloxone results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Naloxone affects the reaction [Methadone binds to TLR4 protein]; Naloxone affects the reaction [Morphine binds to TLR4 protein] CTD PMID:20178837 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Naloxone results in decreased expression of TNF protein
CTD PMID:16004788 PMID:17084265 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Naloxone results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]; Naloxone inhibits the reaction [Morphine results in increased expression of TP53]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein]
Naloxone results in decreased expression of TP53 mRNA
CTD PMID:12927789 PMID:17522070 PMID:19397953 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Naloxone results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects metabolic processing
increases glucuronidation
ISO UGT2B7 protein affects the metabolism of Naloxone
UGT2B7 protein results in increased glucuronidation of Naloxone
CTD PMID:15286053 PMID:28762043 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
naltrexone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein] CTD PMID:27323860 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion
EXP Naltrexone affects the reaction [Dynorphins results in decreased secretion of CRH protein]; Naltrexone inhibits the reaction [beta-Endorphin results in decreased secretion of CRH protein]
Naltrexone results in increased secretion of CRH protein
CTD PMID:3031743 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein] CTD PMID:27323860 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Drd2 dopamine receptor D2 affects response to substance ISO DRD2 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO Naltrexone promotes the reaction [Ethanol results in increased expression of EGR1 mRNA]
Naltrexone results in increased expression of EGR1 mRNA
CTD PMID:18427989 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:27323860 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein] CTD PMID:27323860 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases secretion
increases expression
ISO Naltrexone results in increased secretion of FSHB protein
Naltrexone results in increased expression of FSHB protein
CTD PMID:6323369 PMID:7745028 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 affects response to substance ISO GABRA6 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance ISO GABRB2 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA] CTD PMID:27323860 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
increases secretion
ISO Naltrexone results in increased expression of LHB protein
Naltrexone results in increased secretion of LHB protein
CTD PMID:6323369 PMID:7745028 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity ISO Naltrexone results in decreased activity of NOS2 protein CTD PMID:15694688 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ogfr opioid growth factor receptor increases expression ISO Naltrexone results in increased expression of OGFR CTD PMID:21685240 NCBI chr 3:167,703,173...167,709,459
Ensembl chr 3:167,702,695...167,709,473
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Naltrexone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Naltrexone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
affects response to substance
ISO
EXP
[[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP
Naltrexone binds to OPRM1 protein
OPRM1 affects the susceptibility to Naltrexone
CTD PMID:7562497 PMID:11413242 PMID:18250251 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects response to substance
ISO Naltrexone inhibits the reaction [Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]]
SLC6A3 gene polymorphism affects the susceptibility to Naltrexone
CTD PMID:9765353 PMID:18552399 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Naltrexone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:15917999 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      biological role 19763
        pharmacological role 18850
          antagonist 16338
            opioid receptor antagonist 102
              delta-opioid receptor antagonist + 18
              kappa-opioid receptor antagonist + 18
              mu-opioid receptor antagonist + 91
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19763
      application 19477
        pharmaceutical 19327
          drug 19327
            neurotransmitter agent 16461
              opioid agent 680
                opioid receptor antagonist 102
                  delta-opioid receptor antagonist + 18
                  kappa-opioid receptor antagonist + 18
                  mu-opioid receptor antagonist + 91
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