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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:opioid agent
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Accession:CHEBI:60598 term browser browse the term
Definition:Any agent that acts on an opioid receptor or affects the life cycle of an opioid transmitter.
Synonyms:related_synonym: opioid agents


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(R,R)-tramadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases expression EXP Tramadol results in increased expression of ADRA1A protein CTD PMID:15464068 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Tramadol results in increased expression of BAX protein CTD PMID:25550769 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Tramadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Casp3 caspase 3 affects activity
decreases activity		 ISO
EXP		 Tramadol affects the activity of CASP3 protein
Tramadol results in decreased activity of CASP3 protein		 CTD PMID:27317026 PMID:28499616 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases expression
multiple interactions		 EXP Tramadol results in decreased expression of CAT mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]		 CTD PMID:25550769 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ckb creatine kinase B decreases expression
multiple interactions		 ISO
EXP		 Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]		 CTD PMID:27317026 PMID:33645892 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein] CTD PMID:33645892 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Tramadol results in decreased activity of CYP17A1 protein CTD PMID:29100959 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing		 ISO CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol		 CTD PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Des desmin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of DES protein] CTD PMID:33645892 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699 		JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Tramadol results in increased expression of DRD2 protein CTD PMID:15464068 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Tramadol results in increased expression of DRD3 protein CTD PMID:15464068 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein] CTD PMID:33645892 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Tramadol results in increased activity of GPT protein CTD PMID:28689766 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases activity
increases expression
multiple interactions		 EXP Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]		 CTD PMID:18417104 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928 		JBrowse link
G Ifng interferon gamma multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein] CTD PMID:33645892 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Tramadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Tramadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions		 EXP Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin		 CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions		 EXP Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin		 CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding
multiple interactions		 EXP Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin		 CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO Tramadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:58,477,471...58,553,932
Ensembl chr  X:58,486,554...58,553,557 		JBrowse link
G Pdyn prodynorphin decreases expression EXP Tramadol results in decreased expression of PDYN mRNA CTD PMID:17401159 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA CTD PMID:31276069 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA CTD PMID:31276069 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:11723065 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions		 EXP Tramadol results in decreased expression of SOD1 mRNA
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]		 CTD PMID:25550769 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression		 EXP Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA		 CTD PMID:25550769 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression		 EXP Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein] CTD PMID:33645892 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP [Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:17377112 PMID:33645892 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions
increases expression		 EXP Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein] CTD PMID:33645892 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Vim vimentin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein] CTD PMID:33645892 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
alfentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions ISO CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]; CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions		 ISO CYP3A4 protein affects the metabolism of Alfentanil
CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]		 CTD PMID:15557344 PMID:15731592 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
affects metabolic processing		 ISO CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344 PMID:15731592 PMID:17554244 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Alfentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
buprenorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor decreases expression EXP Buprenorphine results in decreased expression of BDNF protein CTD PMID:24321744 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP
ISO		 Buprenorphine results in decreased activity of CAT protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein		 CTD PMID:25683329 PMID:32113805 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of CREB1 protein CTD PMID:24321744 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing ISO CYP2C8 protein affects the metabolism of Buprenorphine CTD PMID:16010532
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity		 ISO CYP2D6 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP2D6 protein		 CTD PMID:12756210 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
decreases alkylation
increases metabolic processing
decreases activity		 ISO CYP3A4 protein affects the metabolism of Buprenorphine
CYP3A4 protein results in decreased alkylation of Buprenorphine
CYP3A4 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP3A4 protein		 CTD PMID:12756210 PMID:15966752 PMID:16010532 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Buprenorphine results in increased activity of GPT protein CTD PMID:25683329 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Buprenorphine results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 increases expression ISO Buprenorphine results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of NTRK2 protein CTD PMID:24321744 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions		 EXP
ISO		 Buprenorphine binds to OPRD1 protein
Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]		 CTD PMID:7562497 PMID:21866885 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions		 EXP
ISO		 Buprenorphine binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]		 CTD PMID:7562497 PMID:21866885 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO Buprenorphine binds to and results in increased activity of OPRL1 protein CTD PMID:10998549 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding		 ISO
EXP		 Buprenorphine binds to and affects the activity of OPRM1 protein; Buprenorphine binds to and results in increased activity of OPRM1 protein; Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]
Buprenorphine binds to OPRM1 protein		 CTD PMID:7562497 PMID:16010532 PMID:21866885 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases activity EXP Buprenorphine results in decreased activity of PRKACA protein CTD PMID:24321744 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Buprenorphine CTD PMID:12756209 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
butorphanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects activity EXP Butorphanol affects the activity of OPRD1 protein CTD PMID:17909753 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity EXP Butorphanol affects the activity of OPRK1 protein CTD PMID:17909753 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects activity
increases activity		 ISO
EXP		 Butorphanol affects the activity of OPRM1 protein
Butorphanol results in increased activity of OPRM1 protein		 CTD PMID:17909753 PMID:32734307 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Butorphanol affects the localization of PRKCD protein CTD PMID:29669290 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
carfentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of carfentanil CTD PMID:33652071
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of carfentanil CTD PMID:33652071 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of carfentanil CTD PMID:33652071 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Capsaicin inhibits the reaction [carfentanil binds to OPRM1 protein]; Cocaine affects the reaction [carfentanil binds to OPRM1 protein] CTD PMID:12406535 PMID:15953495 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
codeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Codeine results in increased secretion of CCL2 protein CTD PMID:17441793 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Codeine affects the secretion of and affects the expression of CCL5 protein CTD PMID:17441793 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Codeine analog CTD PMID:25445008 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance
decreases methylation		 ISO CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine
[CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
[CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CYP2D6 protein polymorphism affects the susceptibility to Codeine
CYP2D6 protein results in decreased methylation of Codeine
CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine		 CTD PMID:9696456 PMID:10911933 PMID:11823760 PMID:15286053 PMID:15625333 More... NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions		 ISO CYP3A4 protein affects the metabolism of Codeine
CYP3A4 protein results in increased metabolism of Codeine
[CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine		 CTD PMID:15286053 PMID:16595712 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Codeine results in decreased activity of KCNH2 protein CTD PMID:19034038 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Codeine binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Codeine binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Codeine binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
codeinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 6-codeinone results in increased expression of BAX protein CTD PMID:12894543 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 6-codeinone results in decreased expression of BCL2 protein CTD PMID:12894543 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage		 ISO 6-codeinone results in increased activity of CASP3 protein
6-codeinone results in increased cleavage of CASP3 protein		 CTD PMID:12606908 PMID:12894543 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases activity ISO 6-codeinone results in increased activity of CASP9 protein CTD PMID:12894543 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 6-codeinone affects the localization of CYCS protein CTD PMID:12894543 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
dextropropoxyphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Ces1d carboxylesterase 1D affects binding ISO Dextropropoxyphene binds to CES1 protein CTD PMID:10381793 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Dextropropoxyphene binds to CES2 protein CTD PMID:10381793 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding		 EXP [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding		 EXP [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding		 EXP [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dextropropoxyphene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
DPDPE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects export EXP ABCC2 protein affects the export of Enkephalin, D-Penicillamine (2,5)- CTD PMID:15528320 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Enkephalin, D-Penicillamine (2,5)- CTD PMID:11880531 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases secretion ISO HNF4A protein results in increased secretion of Enkephalin, D-Penicillamine (2,5)- CTD PMID:27160211 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding
increases expression		 EXP
ISO		 [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum; [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]
7-hydroxymitragynine affects the reaction [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein]; Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]; Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein
Enkephalin, D-Penicillamine (2,5)- binds to OPRD1 protein
Enkephalin, D-Penicillamine (2,5)- results in increased expression of OPRD1 mRNA		 CTD PMID:7477890 PMID:7562497 PMID:9302088 PMID:19279569 PMID:21866885 More... NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Enkephalin, D-Penicillamine (2,5)- binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Enkephalin, D-Penicillamine (2,5)- binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects transport
affects uptake		 ISO
EXP		 SLCO1A4 protein affects the transport of Enkephalin, D-Penicillamine (2,5)-
SLCO1A4 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)-		 CTD PMID:15528320 PMID:19833843 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects uptake EXP SLCO1B2 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)- CTD PMID:15528320 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
eluxadoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to eluxadoline CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
fentanyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
increases response to substance		 ISO
EXP		 ABCB1 protein results in increased transport of Fentanyl
tariquidar inhibits the reaction [ABCB1 protein results in increased transport of Fentanyl]
ABCB1 protein results in increased susceptibility to Fentanyl		 CTD PMID:29669042 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Arrb2 arrestin, beta 2 affects localization ISO Fentanyl affects the localization of ARRB2 protein CTD PMID:27030709 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]] CTD PMID:27030709 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Crh corticotropin releasing hormone affects expression EXP Fentanyl affects the expression of CRH mRNA CTD PMID:18819432 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Fentanyl CTD PMID:11811955 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Fentanyl results in increased expression of FOS protein CTD PMID:7970238 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gast gastrin multiple interactions EXP [fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Fentanyl results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 increases expression ISO Fentanyl results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fentanyl results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Fentanyl results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases phosphorylation ISO Fentanyl results in increased phosphorylation of OPRM1 protein CTD PMID:17240843 PMID:21957251 PMID:23300227 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pdyn prodynorphin increases expression EXP Fentanyl results in increased expression of PDYN protein CTD PMID:19200067 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pld2 phospholipase D2 increases activity ISO Fentanyl results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions		 ISO Fentanyl results in decreased expression of POMC protein alternative form
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form		 CTD PMID:20084599 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ren renin multiple interactions ISO [Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein CTD PMID:3284271 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489 		JBrowse link
heroin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases metabolic processing		 ISO [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Actn2 actinin alpha 2 decreases expression ISO Heroin results in decreased expression of ACTN2 mRNA CTD PMID:16710320 NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622 		JBrowse link
G Amph amphiphysin decreases expression ISO Heroin results in decreased expression of AMPH mRNA CTD PMID:16710320 NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315 		JBrowse link
G App amyloid beta precursor protein decreases expression ISO Heroin results in decreased expression of APP mRNA CTD PMID:16710320 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases metabolic processing		 ISO [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions		 ISO
EXP		 Heroin results in decreased expression of BDNF protein
Heroin results in decreased expression of BDNF mRNA
Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]		 CTD PMID:17715210 PMID:25643298 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 decreases expression ISO Heroin results in decreased expression of BLOC1S6 mRNA CTD PMID:16710320 NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:109,816,366...109,828,308 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein] CTD PMID:20600547 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ces1d carboxylesterase 1D decreases acetylation
increases hydrolysis
multiple interactions
affects binding		 ISO CES1 protein results in decreased acetylation of Heroin
CES1 protein results in increased hydrolysis of Heroin
Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
Heroin binds to CES1 protein		 CTD PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis		 ISO Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin] CTD PMID:8930175 PMID:9169443 PMID:25445008 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Heroin results in decreased expression of CHURC1 mRNA CTD PMID:16710320 NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:95,470,683...95,619,586 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter] CTD PMID:25643298 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression ISO Heroin results in decreased expression of DEAF1 mRNA CTD PMID:16710320 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541 		JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Heroin results in decreased expression of DNPH1 mRNA CTD PMID:16710320 NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO Heroin results in decreased expression of DRD2 protein CTD PMID:11126397 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A decreases expression ISO Heroin results in decreased expression of EIF5A mRNA CTD PMID:16710320 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656 		JBrowse link
G Enho energy homeostasis associated decreases expression ISO Heroin results in decreased expression of ENHO mRNA CTD PMID:16710320 NCBI chr 5:56,800,980...56,802,777
Ensembl chr 5:56,800,980...56,802,777 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Heroin results in increased expression of FAS mRNA CTD PMID:16710320 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions		 EXP Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein
Dronabinol affects the reaction [Heroin results in increased expression of FOS protein]		 CTD PMID:16137723 PMID:19169671 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IFNG protein CTD PMID:16766138 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL10 protein CTD PMID:16766138 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL2 protein CTD PMID:16766138 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 increases expression ISO Heroin results in increased expression of ITGB1BP1 mRNA CTD PMID:16710320 NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037 		JBrowse link
G Ngf nerve growth factor decreases expression ISO Heroin results in decreased expression of NGF protein CTD PMID:17715210 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP Heroin results in decreased expression of NR4A2 mRNA CTD PMID:25643298 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Heroin results in increased expression of NTRK2 mRNA CTD PMID:16710320 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136 		JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO Heroin results in decreased expression of NUCKS1 mRNA CTD PMID:16710320 NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229 		JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO Heroin results in increased expression of PDE4DIP mRNA CTD PMID:16710320 NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379 		JBrowse link
G Pdyn prodynorphin decreases expression ISO Heroin results in decreased expression of PDYN mRNA CTD PMID:16710320 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO Heroin results in decreased expression of PMEPA1 mRNA CTD PMID:16710320 NCBI chr 3:162,011,884...162,060,137
Ensembl chr 3:162,012,751...162,060,454 		JBrowse link
G Prepl prolyl endopeptidase-like decreases expression ISO Heroin results in decreased expression of PREPL mRNA CTD PMID:16710320 NCBI chr 6:9,580,367...9,609,957
Ensembl chr 6:9,580,217...9,607,772 		JBrowse link
G Septin4 septin 4 increases expression ISO Heroin results in increased expression of SEPTIN4 mRNA CTD PMID:16710320 NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768 		JBrowse link
G Slc25a23 solute carrier family 25 member 23 decreases expression ISO Heroin results in decreased expression of SLC25A23 mRNA CTD PMID:16710320 NCBI chr 9:1,882,636...1,898,340
Ensembl chr 9:1,882,621...1,898,561 		JBrowse link
G Slc25a37 solute carrier family 25 member 37 increases expression ISO Heroin results in increased expression of SLC25A37 mRNA CTD PMID:16710320 NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199 		JBrowse link
G Snap25 synaptosome associated protein 25 decreases expression ISO Heroin results in decreased expression of SNAP25 mRNA CTD PMID:16710320 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760 		JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO Heroin results in decreased expression of STXBP1 mRNA CTD PMID:16710320 NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369 		JBrowse link
G Stxbp6 syntaxin binding protein 6 decreases expression ISO Heroin results in decreased expression of STXBP6 mRNA CTD PMID:16710320 NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024 		JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a decreases expression ISO Heroin results in decreased expression of SV2A mRNA CTD PMID:16710320 NCBI chr 2:183,741,455...183,757,290
Ensembl chr 2:183,741,547...183,756,927 		JBrowse link
G Syngr3 synaptogyrin 3 decreases expression ISO Heroin results in decreased expression of SYNGR3 mRNA CTD PMID:16710320 NCBI chr10:13,710,553...13,715,312
Ensembl chr10:13,704,998...13,715,669 		JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Heroin results in decreased expression of SYT1 mRNA CTD PMID:16710320 NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Heroin results in increased expression of TFRC mRNA CTD PMID:16710320 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of TNF protein CTD PMID:16766138 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO Heroin results in decreased expression of UGCG mRNA CTD PMID:16710320 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393 		JBrowse link
G Vti1b vesicle transport through interaction with t-SNAREs 1B decreases expression ISO Heroin results in decreased expression of VTI1B mRNA CTD PMID:16710320 NCBI chr 6:97,957,700...97,976,491
Ensembl chr 6:97,961,346...97,976,465 		JBrowse link
hydrocodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects binding EXP Hydrocodone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Hydrocodone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Hydrocodone binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
hydromorphone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Hydromorphone affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Hydromorphone results in increased activity of OPRM1 protein CTD PMID:32734307 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions		 ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]		 CTD PMID:10873616 NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541 		JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
decreases expression
multiple interactions
increases transport
affects response to substance		 ISO Loperamide binds to ABCB1 protein
Loperamide results in decreased expression of ABCB1 mRNA
Loperamide inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]
ABCB1 protein results in increased transport of Loperamide
ABCB1A protein affects the susceptibility to Loperamide		 CTD PMID:15502009 PMID:23976943 PMID:34719826 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loperamide CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]
Loperamide results in decreased expression of BCL2 mRNA		 CTD PMID:34719826 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Cat catalase decreases expression EXP Loperamide results in decreased expression of CAT protein CTD PMID:30597669 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions		 ISO Loperamide results in increased expression of CDKN1A mRNA
Loperamide promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]		 CTD PMID:34719826 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Ces2h carboxylesterase 2H decreases activity
multiple interactions		 ISO Loperamide results in decreased activity of CES2 protein
[Loperamide results in decreased activity of CES2 protein] which results in increased susceptibility to Bisphenol A-Glycidyl Methacrylate		 CTD PMID:15687373 PMID:21951919 PMID:28647665 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Ckb creatine kinase B multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases secretion EXP Loperamide results in increased secretion of GOT1 protein CTD PMID:30597669 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Loperamide results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 increases expression ISO Loperamide results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
multiple interactions		 ISO Loperamide results in decreased expression of MAPK8 mRNA
Loperamide promotes the reaction [Doxorubicin results in decreased expression of MAPK8 mRNA]		 CTD PMID:34719826 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression		 ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of MTOR mRNA]
Loperamide results in decreased expression of MTOR mRNA		 CTD PMID:34719826 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Loperamide results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Loperamide binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to Loperamide CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Pld2 phospholipase D2 increases activity ISO Loperamide results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Loperamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion EXP Loperamide results in increased secretion of TNNI3 protein CTD PMID:30597669 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
methadone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
affects activity		 ISO Methadone results in increased expression of ABCB1 protein
Methadone affects the activity of ABCB1 protein		 CTD PMID:19840843 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects activity
increases expression		 EXP Methadone affects the activity of ABCB1B protein
Methadone results in increased expression of ABCB1B protein		 CTD PMID:19840843 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO Methadone affects the localization of BAX protein CTD PMID:20691259 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Methadone results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Methadone results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CX3CL1 protein CTD PMID:20178837 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Methadone affects the localization of CYCS protein CTD PMID:20691259 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
affects metabolic processing		 ISO Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone] CTD PMID:15242824 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity		 ISO CYP2D22 protein results in increased metabolism of Methadone
Methadone results in decreased activity of CYP2D6 protein		 CTD PMID:16595712 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing		 ISO CYP3A4 protein affects the metabolism of Methadone
CYP3A4 protein results in increased metabolism of Methadone		 CTD PMID:15986265 PMID:16595712 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA] CTD PMID:18990547 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of HCRT mRNA] CTD PMID:18990547 NCBI chr10:85,689,992...85,691,206
Ensembl chr10:85,689,465...85,691,210 		JBrowse link
G Il10 interleukin 10 increases secretion EXP Methadone results in increased secretion of IL10 protein CTD PMID:20178837 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Methadone results in increased expression of IL1A protein CTD PMID:20178837 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression		 EXP Methadone results in increased secretion of IL1B protein
Methadone results in increased expression of IL1B protein		 CTD PMID:20178837 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 decreases expression ISO Methadone results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions		 ISO Methadone results in increased expression of IL4 mRNA; Methadone results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA]		 CTD PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases expression
increases secretion		 EXP Methadone results in increased expression of IL6 mRNA; Methadone results in increased expression of IL6 protein
Methadone results in increased secretion of IL6 protein		 CTD PMID:20178837 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins2 insulin 2 decreases response to substance ISO Methadone results in decreased susceptibility to INS protein CTD PMID:2554359 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO Chlorobutanol promotes the reaction [Methadone results in decreased activity of KCNH2 protein] CTD PMID:14527710 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Lep leptin increases expression ISO Methadone results in increased expression of LEP protein CTD PMID:15717844 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Methadone results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions		 EXP Methadone binds to OPRD1 protein
[Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin		 CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions		 EXP Methadone binds to OPRK1 protein
[Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin		 CTD PMID:7562497 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding		 EXP [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Pld2 phospholipase D2 increases activity ISO Methadone results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Prl prolactin affects secretion
increases secretion
increases expression		 ISO Methadone affects the secretion of PRL protein
Methadone results in increased secretion of PRL protein
Methadone results in increased expression of PRL protein		 CTD PMID:2554359 PMID:16675813 PMID:21094671 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Tlr4 toll-like receptor 4 affects binding
increases expression
affects response to substance
multiple interactions		 ISO
EXP		 Methadone binds to TLR4 protein
Methadone results in increased expression of TLR4 mRNA; Methadone results in increased expression of TLR4 protein
Methadone affects the susceptibility to TLR4 protein
Naloxone affects the reaction [Methadone binds to TLR4 protein]		 CTD PMID:20178837 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression		 EXP Methadone results in increased secretion of TNF protein
Methadone results in increased expression of TNF protein		 CTD PMID:20178837 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
morphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects metabolic processing
multiple interactions		 ISO
EXP		 ABCB1 affects the metabolism of Morphine
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA		 CTD PMID:23748253 PMID:26554626 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 decreases expression ISO Morphine results in decreased expression of ABTB3 mRNA CTD PMID:21955143 NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression
multiple interactions		 EXP Morphine results in decreased expression of ACAT1 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of ACAT1 protein]		 CTD PMID:23056601 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Ache acetylcholinesterase multiple interactions
increases chemical synthesis		 ISO [ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
ACHE protein results in increased chemical synthesis of Morphine		 CTD PMID:30080993 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Adcy1 adenylate cyclase 1 multiple interactions ISO [ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine CTD PMID:16914643 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969 		JBrowse link
G Adcy6 adenylate cyclase 6 affects expression EXP Morphine affects the expression of ADCY6 mRNA CTD PMID:15829634 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754 		JBrowse link
G Adcy8 adenylate cyclase 8 affects response to substance
affects expression
multiple interactions		 ISO
EXP		 ADCY8 protein affects the susceptibility to Morphine
Morphine affects the expression of ADCY8 mRNA
[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine		 CTD PMID:15829634 PMID:16914643 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Morphine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:194,629,744...194,673,254
Ensembl chr 1:194,629,726...194,672,550 		JBrowse link
G Adora1 adenosine A1 receptor affects response to substance
increases expression
multiple interactions		 ISO
EXP		 ADORA1 protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA1 mRNA; Morphine results in increased expression of ADORA1 protein
[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein		 CTD PMID:9407998 PMID:26478469 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801 		JBrowse link
G Adora2a adenosine A2a receptor affects response to substance
increases expression		 ISO ADORA2A protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA2A mRNA		 CTD PMID:14756803 PMID:21955143 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Agrp agouti related neuropeptide increases expression ISO Morphine results in increased expression of AGRP mRNA CTD PMID:20144693 NCBI chr19:33,447,992...33,523,068
Ensembl chr19:33,447,992...33,449,584 		JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions EXP [lead acetate co-treated with Morphine] results in increased expression of AIF1 mRNA CTD PMID:26478469 NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668 		JBrowse link
G Ak5 adenylate kinase 5 decreases expression ISO Morphine results in decreased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 decreases expression EXP Morphine results in decreased expression of AKR1B1 protein CTD PMID:23056601 NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
decreases expression		 ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]
Morphine results in increased expression of AKT1 protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form]		 CTD PMID:19239323 PMID:20600172 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin multiple interactions
decreases expression		 EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of ALB protein] CTD PMID:23056601 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ano3 anoctamin 3 increases expression ISO Morphine results in increased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154 		JBrowse link
G Anxa6 annexin A6 decreases expression EXP Morphine results in decreased expression of ANXA6 protein CTD PMID:23056601 NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433 		JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP Morphine results in increased expression of APOA1 protein CTD PMID:23056601 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apob apolipoprotein B increases expression ISO Morphine results in increased expression of APOB protein CTD PMID:18980684 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Apoe apolipoprotein E increases expression
multiple interactions		 EXP Morphine results in increased expression of APOE protein
Morphine deficiency affects the reaction [Morphine results in increased expression of APOE protein]		 CTD PMID:23056601 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Morphine results in increased expression of AQP1 mRNA CTD PMID:21178816 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Morphine results in increased expression of AQP3 mRNA; Morphine results in increased expression of AQP3 protein CTD PMID:25766885 NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720 		JBrowse link
G Aqp4 aquaporin 4 decreases expression ISO Morphine results in decreased expression of AQP4 mRNA CTD PMID:21955143 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856 		JBrowse link
G Arl4d ADP-ribosylation factor like GTPase 4D increases expression ISO Morphine results in increased expression of ARL4D mRNA CTD PMID:20144693 NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836 		JBrowse link
G Arl6ip5 ADP-ribosylation factor like GTPase 6 interacting protein 5 multiple interactions
increases expression		 ISO
EXP		 ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine results in increased expression of ARL6IP5 protein
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]		 CTD PMID:21600884 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608 		JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression
decreases expression		 ISO Morphine results in increased expression of ARPP21 mRNA
Morphine deficiency results in decreased expression of ARPP21 mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297 		JBrowse link
G Arrb2 arrestin, beta 2 affects response to substance
multiple interactions		 ISO ARRB2 gene SNP affects the susceptibility to Morphine
ARRB2 protein affects the susceptibility to Morphine
[gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]		 CTD PMID:16103897 PMID:19239323 PMID:19477204 PMID:23300227 PMID:24063433 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Art3 ADP-ribosyltransferase 3 multiple interactions
increases expression		 EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein] CTD PMID:23056601 NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407 		JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 increases expression ISO Morphine results in increased expression of ASIC4 mRNA CTD PMID:21178816 NCBI chr 9:76,941,532...76,962,900
Ensembl chr 9:76,941,532...76,962,900 		JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase decreases expression EXP Morphine results in decreased expression of ATIC protein CTD PMID:23056601 NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889 		JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Morphine results in increased expression of ATRX mRNA CTD PMID:21955143 NCBI chr  X:70,850,981...70,997,330
Ensembl chr  X:70,850,981...70,997,330 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO Morphine results in decreased expression of AVPR1A mRNA CTD PMID:21178816 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP Morphine results in increased expression of BAG3 protein CTD PMID:23056601 NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Morphine results in increased expression of BAK1 protein CTD PMID:19070643 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression		 ISO
EXP		 [[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
Morphine results in increased expression of BAX mRNA; Morphine results in increased expression of BAX protein
Morphine results in decreased expression of BAX mRNA
Lithium inhibits the reaction [Morphine results in increased expression of BAX mRNA]
TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein]		 CTD PMID:10534122 PMID:10809959 PMID:12196588 PMID:12702572 PMID:12927789 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Morphine results in increased expression of BBC3 mRNA CTD PMID:19397953 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcas1 brain enriched myelin associated protein 1 decreases expression ISO Morphine results in decreased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:159,136,233...159,211,925
Ensembl chr 3:159,136,083...159,219,106 		JBrowse link
G Bche butyrylcholinesterase increases chemical synthesis
multiple interactions		 ISO BCHE protein results in increased chemical synthesis of Morphine
[BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine		 CTD PMID:30080993 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl11b BCL11 transcription factor B increases expression
decreases expression		 ISO Morphine results in increased expression of BCL11B mRNA
Morphine deficiency results in decreased expression of BCL11B mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO
EXP		 [[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]
Morphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 protein
Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]		 CTD PMID:10534122 PMID:12196588 PMID:12927789 PMID:17542780 PMID:18976035 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Morphine results in decreased expression of BCL2L1 mRNA CTD PMID:15183518 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO Morphine results in increased expression of BCL2L11 protein CTD PMID:19292871 NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
decreases expression
multiple interactions		 ISO
EXP		 Morphine results in increased expression of BDNF mRNA; Morphine results in increased expression of BDNF protein
Morphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative form
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]
AM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein]; BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]		 CTD PMID:19033880 PMID:25643298 PMID:27461790 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]
Morphine results in increased expression of BECN1 protein		 CTD PMID:20190558 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bex4 brain expressed, X-linked 4 increases expression ISO Morphine results in increased expression of BEX4 mRNA CTD PMID:21178816 NCBI chr  X:99,132,076...99,133,413
Ensembl chr  X:99,131,942...99,133,531 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Morphine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G C1ql3 complement C1q like 3 increases expression ISO Morphine results in increased expression of C1QL3 mRNA CTD PMID:21178816 NCBI chr17:76,121,832...76,128,327
Ensembl chr17:76,119,447...76,128,530 		JBrowse link
G Calb1 calbindin 1 increases expression ISO Morphine results in increased expression of CALB1 mRNA CTD PMID:21178816 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression
multiple interactions		 EXP
ISO		 Morphine results in increased expression of CALCA mRNA; Morphine results in increased expression of CALCA protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]
GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]		 CTD PMID:16935424 PMID:20359526 PMID:20568289 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha affects response to substance
increases expression		 ISO CAMK2A protein affects the susceptibility to Morphine
Morphine results in increased expression of CAMK2A mRNA		 CTD PMID:20053885 PMID:21955143 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994 		JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Morphine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769 		JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO Morphine results in increased expression of CAR2 mRNA CTD PMID:20144693 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 increases expression ISO Morphine results in increased expression of CARHSP1 mRNA CTD PMID:21178816 NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019 		JBrowse link
G Cartpt CART prepropeptide increases expression ISO Morphine results in increased expression of CARTPT mRNA CTD PMID:20144693 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713 		JBrowse link
G Casp1 caspase 1 decreases expression EXP Morphine results in decreased expression of CASP1 mRNA CTD PMID:15183518 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression		 ISO
EXP		 [[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Morphine results in increased activity of and results in increased cleavage of CASP3 protein; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Morphine results in increased expression of CASP3 protein
Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form]; SB 203580 inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Morphine results in increased expression of CASP3 protein; Morphine results in increased expression of CASP3 protein alternative form		 CTD PMID:10534122 PMID:11590188 PMID:12196588 PMID:16102899 PMID:17542780 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
decreases expression		 ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
Morphine results in increased activity of CASP8 protein		 CTD PMID:11590188 PMID:19070643 PMID:19239323 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases activity
increases expression		 ISO
EXP		 Morphine results in increased activity of CASP9 protein
Morphine results in increased expression of CASP9 mRNA		 CTD PMID:15183518 PMID:19292871 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Morphine results in increased abundance of Hydrogen Peroxide] CTD PMID:14871405 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cbln1 cerebellin 1 precursor decreases expression ISO Morphine results in decreased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572 		JBrowse link
G Ccdc136 coiled-coil domain containing 136 decreases expression ISO Morphine results in decreased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:57,997,825...58,027,598
Ensembl chr 4:57,997,853...58,027,646 		JBrowse link
G Cck cholecystokinin decreases expression ISO Morphine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Morphine CTD PMID:11403953 PMID:11880531 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Morphine results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Morphine results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression		 ISO beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein]; Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Cd38 CD38 molecule affects response to substance ISO CD38 affects the susceptibility to Morphine CTD PMID:20551293 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986 		JBrowse link
G Cd79b CD79b molecule increases expression ISO Morphine results in increased expression of CD79B mRNA CTD PMID:20144693 NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625 		JBrowse link
G Cd9 CD9 molecule increases expression EXP Morphine results in increased expression of CD9 protein CTD PMID:23056601 NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222 		JBrowse link
G Cdh22 cadherin 22 increases expression ISO Morphine results in increased expression of CDH22 mRNA CTD PMID:21178816 NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein CTD PMID:12702572 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cep83 centrosomal protein 83 increases expression ISO Morphine results in increased expression of CEP83 mRNA CTD PMID:20144693 NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574 		JBrowse link
G Ces2h carboxylesterase 2H increases chemical synthesis
multiple interactions		 ISO CES2 protein results in increased chemical synthesis of Morphine
Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]		 CTD PMID:8930175 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830 		JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects response to substance ISO CHRM5 protein affects the susceptibility to Morphine CTD PMID:12154229 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252 		JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Morphine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818 		JBrowse link
G Cldn2 claudin 2 increases expression ISO Morphine results in increased expression of CLDN2 mRNA CTD PMID:21178816 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Morphine results in decreased expression of CMBL protein CTD PMID:23056601 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009 		JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 increases expression ISO Morphine results in increased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:28,412,624...28,415,304
Ensembl chr15:28,412,624...28,415,287 		JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein multiple interactions
decreases expression		 EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of CNBP protein] CTD PMID:23056601 NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637 		JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases expression
increases expression		 EXP
ISO		 [Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
Morphine deficiency results in decreased expression of CNR1 mRNA
CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]		 CTD PMID:9351646 PMID:21955143 PMID:22258905 PMID:27126842 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Comt catechol-O-methyltransferase affects response to substance
multiple interactions		 ISO COMT protein affects the susceptibility to Morphine
[COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine		 CTD PMID:18834357 PMID:21127283 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642 		JBrowse link
G Coq9 coenzyme Q9 decreases expression EXP Morphine results in decreased expression of COQ9 protein CTD PMID:23056601 NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949 		JBrowse link
G Cpe carboxypeptidase E increases expression ISO Morphine results in increased expression of CPE mRNA CTD PMID:20144693 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
multiple interactions
increases phosphorylation
increases expression
decreases phosphorylation		 EXP
ISO		 Morphine results in decreased expression of CREB1 mRNA
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of CREB1 protein]; suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein]
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]
Morphine results in decreased phosphorylation of CREB1 protein		 CTD PMID:14750654 PMID:15183518 PMID:16598705 PMID:23292329 PMID:25643298 More... NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Morphine results in increased expression of CREM mRNA CTD PMID:22454534 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989 		JBrowse link
G Crh corticotropin releasing hormone increases expression ISO Morphine deficiency results in increased expression of CRH mRNA; Morphine results in increased expression of CRH mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919 		JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions EXP
ISO		 [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]		 CTD PMID:24398105 PMID:25582704 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
G Crp C-reactive protein increases expression ISO Morphine results in increased expression of CRP protein CTD PMID:18980684 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cryab crystallin, alpha B decreases expression
increases expression		 ISO
EXP		 Morphine results in decreased expression of CRYAB mRNA
Morphine results in increased expression of CRYAB protein		 CTD PMID:21955143 PMID:23056601 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157 		JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Morphine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463 		JBrowse link
G Cstb cystatin B decreases expression EXP Morphine results in decreased expression of CSTB protein CTD PMID:23056601 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526 		JBrowse link
G Ctnnal1 catenin alpha-like 1 increases expression ISO Morphine results in increased expression of CTNNAL1 mRNA CTD PMID:21178816 NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431 		JBrowse link
G Ctsb cathepsin B increases expression EXP Morphine results in increased expression of CTSB mRNA CTD PMID:9429908 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Cux2 cut-like homeobox 2 increases expression ISO Morphine results in increased expression of CUX2 mRNA CTD PMID:21178816 NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects response to substance
increases secretion		 EXP CX3CL1 protein affects the susceptibility to Morphine
Morphine results in increased secretion of CX3CL1 protein		 CTD PMID:15317861 PMID:20178837 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833 		JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Morphine results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215 		JBrowse link
G Cxxc1 CXXC finger protein 1 affects expression ISO Morphine affects the expression of CXXC1 mRNA CTD PMID:33891991 NCBI chr18:67,813,185...67,818,556
Ensembl chr18:67,813,206...67,818,551 		JBrowse link
G Cybb cytochrome b-245 beta chain increases expression
multiple interactions		 ISO Morphine results in increased expression of CYBB protein
Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]		 CTD PMID:14871405 NCBI chr  X:13,360,583...13,392,517
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Cycs cytochrome c, somatic increases secretion
decreases secretion
multiple interactions		 ISO
EXP		 Morphine results in increased secretion of CYCS protein
Morphine results in decreased secretion of CYCS protein
Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein]		 CTD PMID:15345483 PMID:17542780 PMID:19292871 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Morphine results in increased expression of CYP27A1 mRNA CTD PMID:20144693 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects chemical synthesis
multiple interactions		 ISO CYP2D6 protein affects the chemical synthesis of Morphine
[CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine		 CTD PMID:15625333 PMID:16595712 PMID:21241245 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
decreases expression		 EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DCXR protein] CTD PMID:23056601 NCBI chr10:106,006,404...106,008,294 JBrowse link
G Ddah2 dimethylarginine dimethylaminohydrolase 2 multiple interactions
increases expression		 EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein] CTD PMID:23056601 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511 		JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression
multiple interactions		 ISO Morphine results in increased expression of DDB2 mRNA
Naloxone inhibits the reaction [Morphine results in increased expression of DDB2]		 CTD PMID:19397953 NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Morphine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:121,344,637...121,368,853
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Dhrs7b dehydrogenase/reductase 7B increases expression ISO Morphine results in increased expression of DHRS7B mRNA CTD PMID:21178816 NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076 		JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Morphine results in decreased expression of DLG4 mRNA; Morphine results in decreased expression of DLG4 protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]
Morphine results in increased expression of DLG4 mRNA		 CTD PMID:15183518 PMID:16598705 PMID:21955143 PMID:22713680 NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153 		JBrowse link
G Dlx5 distal-less homeobox 5 increases expression ISO Morphine results in increased expression of DLX5 mRNA CTD PMID:21178816 NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407 		JBrowse link
G Dnah3 dynein, axonemal, heavy chain 3 decreases expression ISO Morphine results in decreased expression of DNAH3 mRNA CTD PMID:21178816 NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:174,306,644...174,479,474 		JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO Morphine results in increased expression of DNMT1 mRNA CTD PMID:33891991 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha affects expression ISO Morphine affects the expression of DNMT3A mRNA CTD PMID:33891991 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687 		JBrowse link
G Dnmt3b DNA methyltransferase 3 beta affects expression ISO Morphine affects the expression of DNMT3B mRNA CTD PMID:33891991 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124 		JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO Morphine results in increased expression of DOCK10 mRNA CTD PMID:21178816 NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525 		JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions
decreases expression		 EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DPYSL2 protein] CTD PMID:23056601 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829 		JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 multiple interactions
decreases expression		 EXP Morphine deficiency promotes the reaction [Morphine results in decreased expression of DPYSL3 protein] CTD PMID:23056601 NCBI chr18:35,374,429...35,480,462
Ensembl chr18:35,377,181...35,480,157 		JBrowse link
G Drd1 dopamine receptor D1 increases expression
decreases expression		 ISO Morphine results in increased expression of DRD1 mRNA
Morphine deficiency results in decreased expression of DRD1 mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Drd2 dopamine receptor D2 decreases expression
multiple interactions
affects response to substance
increases expression		 EXP
ISO		 Morphine results in decreased expression of DRD2 mRNA
Morphine deficiency results in decreased expression of DRD2 mRNA
[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA; [lead acetate co-treated with Morphine] results in increased expression of DRD2 protein
DRD2 protein affects the susceptibility to Morphine
Morphine results in increased expression of DRD2 mRNA		 CTD PMID:2571179 PMID:15183518 PMID:17063042 PMID:23702354 PMID:27126842 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd4 dopamine receptor D4 increases expression EXP Morphine results in increased expression of DRD4 mRNA CTD PMID:15183518 NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553 		JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases expression ISO Morphine results in increased expression of DSCAML1 mRNA CTD PMID:20144693 NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320 		JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Morphine deficiency results in increased expression of DUSP6 mRNA; Morphine results in increased expression of DUSP6 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185 		JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO Morphine results in decreased expression of DYNC1H1 mRNA CTD PMID:21178816 NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883 		JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Morphine results in decreased expression of ECH1 protein CTD PMID:23056601 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795 		JBrowse link
G Eed embryonic ectoderm development increases expression ISO Morphine results in increased expression of EED mRNA CTD PMID:33891991 NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974 		JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Morphine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Morphine deficiency results in increased expression of EGR1 mRNA; Morphine results in increased expression of EGR1 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Egr2 early growth response 2 increases expression ISO Morphine results in increased expression of EGR2 mRNA CTD PMID:22454534 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562 		JBrowse link
G Egr3 early growth response 3 increases expression ISO Morphine results in increased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627 		JBrowse link
G Egr4 early growth response 4 multiple interactions
increases expression
affects response to substance		 ISO
EXP		 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA]; [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
EGR4 protein affects the susceptibility to Morphine		 CTD PMID:22454534 NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328 		JBrowse link
G Ehd1 EH-domain containing 1 multiple interactions
decreases expression		 EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of EHD1 protein] CTD PMID:23056601 NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212 		JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 affects expression ISO Morphine affects the expression of EHMT1 mRNA CTD PMID:33891991 NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 affects expression ISO Morphine affects the expression of EHMT2 mRNA CTD PMID:33891991 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A increases expression ISO Morphine results in increased expression of EIF5A mRNA CTD PMID:19397953 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656 		JBrowse link
G Elk1 ETS transcription factor ELK1 affects response to substance
increases activity
multiple interactions		 ISO ELK1 protein affects the susceptibility to Morphine
Morphine results in increased activity of ELK1 protein
[Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA		 CTD PMID:22454534 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713 		JBrowse link
G Eml2 EMAP like 2 increases expression EXP Morphine results in increased expression of EML2 protein CTD PMID:23056601 NCBI chr 1:78,827,595...78,859,343
Ensembl chr 1:78,828,080...78,859,341 		JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Morphine results in increased expression of ENPP3 protein CTD PMID:23056601 NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041 		JBrowse link
G Ephx2 epoxide hydrolase 2 increases expression ISO Morphine results in increased expression of EPHX2 mRNA CTD PMID:21178816 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Morphine results in increased expression of ERP44 mRNA CTD PMID:21178816 NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions
affects expression		 EXP
ISO		 Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]
Morphine affects the expression of EZH2 mRNA		 CTD PMID:25643298 PMID:33891991 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G F2 coagulation factor II increases expression
multiple interactions		 EXP Morphine results in increased expression of F2 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of F2 protein]		 CTD PMID:23056601 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G F7 coagulation factor VII increases expression ISO Morphine results in increased expression of F7 protein CTD PMID:18980684 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610 		JBrowse link
G Fam107a family with sequence similarity 107, member A increases expression ISO Morphine results in increased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression		 ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein
Morphine results in increased expression of FAS mRNA		 CTD PMID:12702572 PMID:16210602 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand multiple interactions
increases expression		 ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of FASL mRNA		 CTD PMID:16210602 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fblim1 filamin binding LIM protein 1 increases expression
multiple interactions		 EXP Morphine results in increased expression of FBLIM1 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of FBLIM1 protein]		 CTD PMID:23056601 NCBI chr 5:153,883,946...153,915,524
Ensembl chr 5:153,883,960...153,913,757 		JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO Morphine results in decreased expression of FBN1 mRNA CTD PMID:21178816 NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889 		JBrowse link
G Fga fibrinogen alpha chain affects secretion EXP Morphine affects the secretion of FGA protein modified form CTD PMID:24855564 NCBI chr 2:168,365,364...168,381,533
Ensembl chr 2:168,374,120...168,381,528 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases secretion
multiple interactions		 ISO Morphine results in decreased secretion of FGF2 protein
Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]		 CTD PMID:20564181 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression EXP Morphine results in increased expression of FGFR1 mRNA CTD PMID:15183518 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350 		JBrowse link
G Fh fumarate hydratase increases expression EXP Morphine results in increased expression of FH protein CTD PMID:23056601 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266 		JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions
decreases expression		 EXP Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein] CTD PMID:23056601 NCBI chr 9:45,388,979...45,462,530
Ensembl chr 9:45,388,981...45,431,192 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Morphine results in increased expression of FN1 mRNA CTD PMID:20144693 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression
increases expression		 ISO
EXP		 [Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein; [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Plant Extracts inhibits the reaction [Morphine results in increased expression of FOS protein]
Morphine deficiency affects the expression of FOS protein
Morphine results in increased expression of FOS mRNA; Morphine results in increased expression of FOS protein
Morphine affects the expression of FOS mRNA
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Morphine results in increased expression of FOS protein]; [Morphine co-treated with Cocaine] affects the expression of FOS; [Morphine co-treated with N-Methyl-3,4-methylenedioxyamphetamine] affects the expression of FOS; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; Genistein inhibits the reaction [Morphine results in increased expression of FOS protein]; Morphine affects the reaction [Formaldehyde results in increased expression of FOS protein]; N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide inhibits the reaction [Morphine results in increased expression of FOS protein]; Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; U 0126 inhibits the reaction [Morphine results in increased expression of FOS protein]		 CTD PMID:10521585 PMID:10814832 PMID:12821175 PMID:12934646 PMID:15183518 More... NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 EXP
ISO		 Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]
Morphine results in increased expression of FOSB mRNA
Morphine results in increased expression of FOSB mRNA; Morphine results in increased expression of FOSB protein; Morphine results in increased expression of FOSB protein alternative form; Morphine results in increased expression of FOSB protein modified form		 CTD PMID:15899480 PMID:18293355 PMID:22454534 PMID:23185589 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465 		JBrowse link
G Foxp1 forkhead box P1 increases expression
decreases expression		 ISO Morphine results in increased expression of FOXP1 mRNA
Morphine deficiency results in decreased expression of FOXP1 mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258 		JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Morphine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:86,277,678...86,286,954
Ensembl chr 1:86,277,678...86,286,954 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression
increases expression		 EXP Morphine results in decreased expression of GABRA1 mRNA
Morphine results in increased expression of GABRA1 mRNA		 CTD PMID:15183518 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864 		JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Morphine results in increased expression of GABRA4 mRNA CTD PMID:21178816 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844 		JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Morphine results in increased expression of GABRD mRNA CTD PMID:15183518 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Morphine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346 		JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Morphine results in increased expression of GAD1 mRNA CTD PMID:15673448 PMID:18312583 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Morphine results in increased expression of GAD2 mRNA CTD PMID:21178816 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155 		JBrowse link
G Gal galanin and GMAP prepropeptide increases expression
decreases expression		 ISO Morphine results in increased expression of GAL mRNA
Morphine results in decreased expression of GAL mRNA		 CTD PMID:21178816 PMID:21955143 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Morphine results in decreased expression of GAPDH protein CTD PMID:23056601 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression
decreases expression		 ISO Morphine results in increased expression of GCNT2 mRNA
Morphine deficiency results in decreased expression of GCNT2 mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr17:23,796,859...23,901,625
NCBI chr17:23,866,602...23,868,691
Ensembl chr17:23,796,859...23,901,611 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions		 ISO
EXP		 Morphine results in decreased expression of GFAP mRNA
[lead acetate co-treated with Morphine] results in increased expression of GFAP mRNA		 CTD PMID:21955143 PMID:26478469 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 decreases expression EXP Morphine results in decreased expression of GFM1 protein CTD PMID:23056601 NCBI chr 2:151,700,573...151,745,477
Ensembl chr 2:151,700,564...151,745,471 		JBrowse link
G Gh1 growth hormone 1 decreases expression
increases secretion		 ISO
EXP		 Morphine results in decreased expression of GH mRNA
Morphine results in increased secretion of GH1 protein		 CTD PMID:7201058 PMID:21178816 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078 		JBrowse link
G Gjc2 gap junction protein, gamma 2 decreases expression ISO Morphine results in decreased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467 		JBrowse link
G Glra2 glycine receptor, alpha 2 increases expression ISO Morphine results in increased expression of GLRA2 mRNA CTD PMID:21178816 NCBI chr  X:29,020,377...29,241,666
Ensembl chr  X:29,020,557...29,241,666 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression
multiple interactions
increases expression		 EXP
ISO		 Morphine results in decreased expression of GNAI2 mRNA
Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]
Morphine results in increased expression of GNAI2 mRNA		 CTD PMID:15183518 PMID:18652891 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979 		JBrowse link
G Gnas GNAS complex locus increases expression EXP Morphine results in increased expression of GNAS mRNA; Morphine results in increased expression of GNAS protein CTD PMID:17893922 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262 		JBrowse link
G Gnaz G protein subunit alpha z multiple interactions ISO Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907 		JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Morphine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442 		JBrowse link
G Gng2 G protein subunit gamma 2 increases expression EXP Morphine results in increased expression of GNG2 mRNA CTD PMID:15183518 NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183 		JBrowse link
G Gpr6 G protein-coupled receptor 6 decreases expression ISO Morphine results in decreased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624 		JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression
decreases expression		 ISO Morphine results in increased expression of GPR88 mRNA
Morphine deficiency results in decreased expression of GPR88 mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr 2:204,191,443...204,199,576
Ensembl chr 2:204,191,427...204,199,733 		JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B decreases expression ISO Morphine results in decreased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:173,316,398...173,340,951
Ensembl chr 1:173,316,907...173,340,932 		JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 affects response to substance
multiple interactions
increases expression
decreases expression
decreases phosphorylation		 ISO
EXP		 GRIA1 protein affects the susceptibility to Morphine
Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]
Morphine results in increased expression of GRIA1 mRNA
Morphine results in decreased expression of GRIA1 mRNA; Morphine results in decreased expression of GRIA1 protein
Morphine results in decreased phosphorylation of GRIA1 protein		 CTD PMID:11404432 PMID:15183518 PMID:15287884 PMID:23711322 PMID:25643298 NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283 		JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP Morphine results in decreased expression of GRIA2 protein CTD PMID:23711322 NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510 		JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP Morphine results in decreased expression of GRIA3 mRNA CTD PMID:15183518 NCBI chr  X:120,238,515...120,504,106
Ensembl chr  X:120,238,534...120,504,096 		JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression EXP Morphine results in decreased expression of GRIA4 mRNA CTD PMID:15183518 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions
affects response to substance		 ISO GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
GRIK1 protein affects the susceptibility to Morphine		 CTD PMID:20359526 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
increases expression
decreases phosphorylation
increases phosphorylation
affects phosphorylation		 ISO
EXP		 [Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]
Morphine results in increased expression of GRIN1 protein
Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]; Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein]
Morphine results in decreased phosphorylation of GRIN1 protein
Morphine affects the phosphorylation of GRIN1 protein		 CTD PMID:15287884 PMID:17996026 PMID:20519536 PMID:20950603 PMID:22713680 NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression
affects response to substance		 ISO Morphine results in increased expression of GRIN2A protein
GRIN2A protein affects the susceptibility to Morphine		 CTD PMID:12878694 PMID:33609567 NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases expression
increases phosphorylation		 ISO
EXP		 MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]
Morphine results in increased expression of GRIN2B protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein]		 CTD PMID:20519536 PMID:22713680 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279 		JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C increases expression EXP Morphine results in increased expression of GRIN2C mRNA CTD PMID:15183518 NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427 		JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression EXP Morphine results in increased expression of GRK5 mRNA CTD PMID:15183518 NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701 		JBrowse link
G Grm1 glutamate metabotropic receptor 1 increases expression EXP Morphine results in increased expression of GRM1 mRNA CTD PMID:15183518 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170 		JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression
decreases expression		 ISO Morphine results in increased expression of GRM5 mRNA
Morphine deficiency results in decreased expression of GRM5 mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions		 ISO Morphine results in increased expression of GSK3B protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form]		 CTD PMID:20600172 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hcrtr1 hypocretin receptor 1 increases expression EXP Morphine results in increased expression of HCRTR1 mRNA; Morphine results in increased expression of HCRTR1 protein CTD PMID:32319158 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases response to substance		 ISO HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
HINT1 gene mutant form results in increased susceptibility to Morphine		 CTD PMID:18652891 PMID:21235400 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Morphine results in decreased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100 		JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO Morphine results in increased expression of HMGCS2 mRNA CTD PMID:20144693 NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Morphine results in increased expression of HMOX1 protein CTD PMID:14871405 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 decreases activity
increases activity		 EXP Morphine results in decreased activity of HMOX2 protein
Morphine results in increased activity of HMOX2 protein		 CTD PMID:12812915 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like increases expression ISO Morphine results in increased expression of HNRNPDL mRNA CTD PMID:20144693 NCBI chr14:9,558,079...9,563,654
Ensembl chr14:9,557,425...9,562,506 		JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L increases expression ISO Morphine deficiency results in increased expression of HNRNPL mRNA; Morphine results in increased expression of HNRNPL mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression ISO Morphine results in increased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785 		JBrowse link
G Hp haptoglobin decreases expression EXP Morphine results in decreased expression of HP protein CTD PMID:23056601 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hpca hippocalcin increases expression
decreases expression		 ISO Morphine results in increased expression of HPCA mRNA
Morphine deficiency results in decreased expression of HPCA mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841 		JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases response to substance		 ISO Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine] CTD PMID:12128009 PMID:14569158 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases response to substance		 ISO [zolantidine binds to and results in decreased activity of HRH2 protein] which results in increased susceptibility to Morphine; Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]
HRH2 protein results in decreased susceptibility to Morphine; HRH2 results in decreased susceptibility to Morphine		 CTD PMID:14569158 PMID:16806305 NCBI chr17:10,368,355...10,407,791
Ensembl chr17:10,368,298...10,407,631 		JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Morphine results in increased expression of HS6ST2 mRNA CTD PMID:21178816 NCBI chr  X:130,966,547...131,261,629
Ensembl chr  X:130,968,385...131,261,492 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Morphine results in decreased expression of HSD11B1 mRNA CTD PMID:21955143 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687 		JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP Morphine results in increased expression of HSP90AB1 mRNA CTD PMID:15497504 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression EXP Morphine results in decreased expression of HSP90B1 protein CTD PMID:23056601 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions
increases expression		 EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA]
Morphine results in increased expression of HSPA1A mRNA; Morphine results in increased expression of HSPA1A protein		 CTD PMID:15497504 PMID:23056601 NCBI chr20:3,870,765...3,873,221 JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Morphine results in increased expression of HSPA8 mRNA CTD PMID:15497504 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Morphine results in increased expression of HSPB1 mRNA; Morphine results in increased expression of HSPB1 protein CTD PMID:15497504 PMID:23056601 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Morphine results in increased expression of HSPE1 protein CTD PMID:23056601 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089 		JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions EXP 4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine CTD PMID:10640309 NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442 		JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases expression ISO Morphine results in increased expression of HTR3A mRNA CTD PMID:21178816 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions		 EXP Morphine results in decreased expression of ICAM1 protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]		 CTD PMID:10070497 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression
multiple interactions		 EXP Morphine results in decreased expression of IDH3B protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of IDH3B protein]		 CTD PMID:23056601 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982 		JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions		 ISO Morphine results in decreased expression of IFNG
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]		 CTD PMID:11590188 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Morphine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:129,069,891...129,085,331
Ensembl chr  X:129,069,896...129,085,139 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Morphine affects the expression of [IL12A protein binds to IL12B protein] CTD PMID:16299287 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions
affects expression		 ISO Morphine affects the expression of [IL12A protein binds to IL12B protein]
Morphine affects the expression of IL12B protein		 CTD PMID:16299287 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 increases expression ISO Morphine results in increased expression of IL13 protein CTD PMID:16210602 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression		 ISO Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]; Dexamethasone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Dexamethasone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]; Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion		 EXP
ISO		 Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA]
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]
Morphine results in increased expression of IL1B mRNA; Morphine results in increased expression of IL1B protein
Morphine results in increased secretion of IL1B protein		 CTD PMID:12427855 PMID:20178837 PMID:21081778 PMID:22713680 PMID:24756886 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il1rn interleukin 1 receptor antagonist affects response to substance ISO IL1RN protein affects the susceptibility to Morphine CTD PMID:15317861 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445 		JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions		 ISO Morphine results in decreased expression of IL2
Morphine results in decreased expression of IL2 mRNA
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]		 CTD PMID:11590188 PMID:23965172 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression		 ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of IL4 mRNA; Morphine results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Morphine results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Morphine results in increased expression of IL4 mRNA]		 CTD PMID:16210602 PMID:23965172 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression		 ISO
EXP		 Morphine results in increased secretion of IL6 protein
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]
Morphine results in increased expression of IL6 mRNA; Morphine results in increased expression of IL6 protein
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL6 mRNA]		 CTD PMID:12427855 PMID:15317861 PMID:20564181 PMID:21081778 PMID:22713680 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ing2 inhibitor of growth family, member 2 multiple interactions EXP Morphine promotes the reaction [ING2 protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Morphine results in increased phosphorylation of and results in increased activity of JUN protein; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein] CTD PMID:19292871 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Morphine results in increased expression of JUNB mRNA CTD PMID:21955143 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035 		JBrowse link
G Klf7 KLF transcription factor 7 increases expression
multiple interactions		 ISO Morphine results in increased expression of KLF7 mRNA; Morphine results in increased expression of KLF7 protein
Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA]		 CTD PMID:14644156 NCBI chr 9:65,437,535...65,484,720
NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261 		JBrowse link
G Klrk1 killer cell lectin like receptor K1 decreases expression ISO Morphine results in decreased expression of KLRK1 mRNA CTD PMID:20144693 NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459 		JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions
affects expression		 EXP
ISO		 Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]
Morphine affects the expression of KMT2A mRNA		 CTD PMID:25643298 PMID:33891991 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Krt1 keratin 1 decreases expression EXP Morphine results in decreased expression of KRT1 protein CTD PMID:23056601 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844 		JBrowse link
G Krt10 keratin 10 multiple interactions
decreases expression		 EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of KRT10 protein] CTD PMID:23056601 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701 		JBrowse link
G Krt2 keratin 2 decreases expression
multiple interactions		 EXP Morphine results in decreased expression of KRT2 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT2 protein]		 CTD PMID:23056601 NCBI chr 7:132,941,275...132,947,963
Ensembl chr 7:132,940,862...132,947,963 		JBrowse link
G Krt33a keratin 33A multiple interactions
increases expression		 EXP Morphine deficiency inhibits the reaction [Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]]; Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein] CTD PMID:23056601 NCBI chr10:84,942,991...84,947,478
Ensembl chr10:84,942,573...84,947,478 		JBrowse link
G Krt5 keratin 5 decreases expression EXP Morphine results in decreased expression of KRT5 protein CTD PMID:23056601 NCBI chr 7:132,846,355...132,851,986
Ensembl chr 7:132,846,136...132,851,850 		JBrowse link
G Krt8 keratin 8 multiple interactions
decreases expression		 EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]]; Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein] CTD PMID:23056601 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728 		JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Morphine results in increased expression of LCN2 mRNA CTD PMID:20144693 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Lepr leptin receptor increases expression ISO Morphine results in increased expression of LEPR mRNA CTD PMID:20144693 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Morphine results in decreased expression of LHB protein CTD PMID:7022252 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Morphine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:96,406,825...96,414,137
Ensembl chr 3:96,406,813...96,417,728 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor decreases expression ISO Morphine results in decreased expression of LITAF mRNA CTD PMID:21955143 NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763 		JBrowse link
G Lmo7 LIM domain 7 increases expression ISO Morphine results in increased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:78,567,029...78,769,833
Ensembl chr15:78,567,023...78,769,783 		JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta increases expression ISO Morphine results in increased expression of LMX1B mRNA CTD PMID:19397953 NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899 		JBrowse link
G Lpl lipoprotein lipase increases expression ISO Morphine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249 		JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Morphine results in decreased expression of LRP1 mRNA CTD PMID:21178816 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910 		JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression ISO Morphine results in increased expression of LRPPRC mRNA CTD PMID:20144693 NCBI chr 6:9,859,867...9,942,294
Ensembl chr 6:9,859,867...9,942,293 		JBrowse link
G Map2 microtubule-associated protein 2 decreases expression EXP Morphine results in decreased expression of MAP2 mRNA CTD PMID:15183518 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
increases phosphorylation
multiple interactions		 ISO
EXP		 Morphine results in increased expression of MAPK1 protein modified form
Morphine results in increased phosphorylation of MAPK1 protein
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
Morphine deficiency results in increased phosphorylation of MAPK1 protein; Morphine results in increased phosphorylation of MAPK1 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:15196791 PMID:20359526 PMID:20519536 PMID:21235400 PMID:21483469 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP Morphine results in increased expression of MAPK14 protein CTD PMID:23056601 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine deficiency results in increased phosphorylation of MAPK3 protein; Morphine results in increased phosphorylation of MAPK3 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20519536 PMID:21235400 PMID:21483469 PMID:21600884 PMID:23965172 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapt microtubule-associated protein tau increases expression EXP Morphine results in increased expression of MAPT mRNA CTD PMID:15183518 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression EXP Morphine results in decreased expression of MARCKS protein CTD PMID:23056601 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Mavs mitochondrial antiviral signaling protein increases expression EXP Morphine results in increased expression of MAVS protein CTD PMID:23056601 NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094 		JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 affects expression ISO Morphine affects the expression of MBD1 mRNA CTD PMID:33891991 NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 decreases expression ISO Morphine results in decreased expression of MBD3 mRNA CTD PMID:33891991 NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165 		JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase affects expression ISO Morphine affects the expression of MBD4 mRNA CTD PMID:33891991 NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Morphine results in increased expression of MCL1 mRNA CTD PMID:20144693 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression ISO Morphine results in increased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833 		JBrowse link
G Me3 malic enzyme 3 increases expression ISO Morphine results in increased expression of ME3 mRNA CTD PMID:21178816 NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132 		JBrowse link
G Mir107 microRNA 107 decreases expression ISO Morphine results in decreased expression of MIR107 CTD PMID:20564181 NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853 		JBrowse link
G Mir132 microRNA 132 increases expression ISO Morphine results in increased expression of MIR132 CTD PMID:20564181 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796 		JBrowse link
G Mir146a microRNA 146a increases expression ISO Morphine results in increased expression of MIR146A CTD PMID:20564181 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir150 microRNA 150 increases expression ISO Morphine results in increased expression of MIR150 CTD PMID:20564181 NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108 		JBrowse link
G Mir155 microRNA 155 increases expression ISO Morphine results in increased expression of MIR155 CTD PMID:20564181 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir15b microRNA 15b increases expression ISO Morphine results in increased expression of MIR15B CTD PMID:20564181 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297 		JBrowse link
G Mir191 microRNA 191 decreases expression ISO Morphine results in decreased expression of MIR191 CTD PMID:20564181 NCBI chr 8:109,264,098...109,264,188 JBrowse link
G Mir21 microRNA 21 decreases expression ISO Morphine results in decreased expression of MIR21 CTD PMID:20564181 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir221 microRNA 221 increases expression ISO Morphine results in increased expression of MIR221 CTD PMID:20564181 NCBI chr  X:3,429,465...3,429,573
Ensembl chr  X:3,429,465...3,429,573 		JBrowse link
G Mir23a microRNA 23a increases expression ISO Morphine results in increased expression of MIR23A CTD PMID:20564181 NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071 		JBrowse link
G Mir23b microRNA 23b increases expression ISO Morphine results in increased expression of MIR23B CTD PMID:20564181 NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763 		JBrowse link
G Mir26a microRNA 26a decreases expression ISO Morphine results in decreased expression of MIR26A1 CTD PMID:20564181 NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378 		JBrowse link
G Mir26b microRNA 26b decreases expression ISO Morphine results in decreased expression of MIR26B CTD PMID:20564181 NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680 		JBrowse link
G Mir320a microRNA 320a decreases expression ISO Morphine results in decreased expression of MIR320A CTD PMID:20564181 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mir423 microRNA 423 decreases expression ISO Morphine results in decreased expression of MIR423 CTD PMID:20564181 NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226 		JBrowse link
G Mir99b microRNA 99b decreases expression ISO Morphine results in decreased expression of MIR99B CTD PMID:20564181 NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090 		JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions
increases activity		 EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein]; phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases activity		 ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine results in increased activity of MMP9 protein		 CTD PMID:20519536 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Morphine results in increased expression of MPEG1 mRNA CTD PMID:21178816 NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855 		JBrowse link
G Myo19 myosin XIX decreases expression ISO Morphine results in decreased expression of MYO19 mRNA CTD PMID:21178816 NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression EXP Morphine results in increased expression of NAIP mRNA CTD PMID:15183518 NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542 		JBrowse link
G Nav1 neuron navigator 1 decreases expression ISO Morphine results in decreased expression of NAV1 mRNA CTD PMID:21178816 NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449 		JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression EXP Morphine results in decreased expression of NCAM1 protein modified form CTD PMID:15673448 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014 		JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 affects expression ISO Morphine affects the expression of NDUFAB1 mRNA CTD PMID:20144693 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Morphine results in increased expression of NDUFV2 protein CTD PMID:23056601 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713 		JBrowse link
G Nefh neurofilament heavy chain increases expression EXP Morphine results in increased expression of NEFH mRNA CTD PMID:15183518 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nes nestin decreases expression ISO Morphine results in decreased expression of NES mRNA CTD PMID:26877219 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP Morphine results in increased expression of NFKB1 mRNA CTD PMID:15183518 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
affects response to substance
increases expression
increases degradation
multiple interactions		 ISO
EXP		 Morphine results in increased phosphorylation of NFKBIA protein
NFKBIA protein affects the susceptibility to Morphine
Morphine results in increased expression of NFKBIA protein
Morphine results in increased degradation of NFKBIA protein
Morphine results in increased expression of NFKBIA mRNA; Morphine results in increased expression of NFKBIA protein
Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Cycloheximide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Morphine inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]		 CTD PMID:17542780 PMID:19070643 PMID:22258905 PMID:24068670 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ninj1 ninjurin 1 increases expression ISO Morphine results in increased expression of NINJ1 mRNA CTD PMID:19397953 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
increases expression		 ISO
EXP		 [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]
Morphine results in decreased expression of NOS1 protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]		 CTD PMID:16598705 PMID:20519536 PMID:20568289 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
affects response to substance		 ISO Morphine results in increased expression of NOS2 mRNA; Morphine results in increased expression of NOS2 protein
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]
NOS2 protein affects the susceptibility to Morphine		 CTD PMID:11590188 PMID:15220775 PMID:16325209 PMID:19751225 PMID:24756886 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Npy neuropeptide Y increases expression ISO Morphine results in increased expression of NPY mRNA CTD PMID:20144693 PMID:21178816 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 decreases expression ISO Morphine results in decreased expression of NPY1R mRNA CTD PMID:20144693 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP [Mifepristone binds to and results in decreased activity of NR3C1 protein] which results in decreased susceptibility to Morphine CTD PMID:15014116 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Morphine results in increased expression of NR4A1 mRNA CTD PMID:21955143 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
decreases expression
affects response to substance		 ISO
EXP		 BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]
Morphine results in decreased expression of NR4A2 mRNA
Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]		 CTD PMID:25643298 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877 		JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP Morphine results in increased expression of NRCAM mRNA; Morphine results in increased expression of NRCAM mRNA alternative form CTD PMID:16123759 NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992 		JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Morphine results in decreased expression of NRN1 mRNA CTD PMID:21955143 NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896 		JBrowse link
G Nrxn3 neurexin 3 increases expression ISO Morphine results in increased expression of NRXN3 mRNA CTD PMID:21955143 NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044 		JBrowse link
G Ntng1 netrin G1 decreases expression ISO Morphine results in decreased expression of NTNG1 mRNA CTD PMID:21955143 NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997 		JBrowse link
G Ntsr1 neurotensin receptor 1 affects response to substance ISO NTSR1 protein affects the susceptibility to Morphine CTD PMID:20727387 NCBI chr 3:167,606,215...167,656,377
Ensembl chr 3:167,606,215...167,656,377 		JBrowse link
G Opalin oligodendrocytic myelin paranodal and inner loop protein decreases expression ISO Morphine results in decreased expression of OPALIN mRNA CTD PMID:21955143 NCBI chr 1:239,891,137...239,909,388
Ensembl chr 1:239,891,142...239,908,788 		JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
increases expression
affects binding		 ISO
EXP		 ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine binds to OPRD1 protein		 CTD PMID:7562497 PMID:21600884 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960 		JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity
increases activity
increases expression
affects binding
multiple interactions		 ISO
EXP		 Morphine affects the activity of OPRK1 protein
Morphine results in increased activity of OPRK1 protein
Morphine results in increased expression of OPRK1 mRNA
Morphine binds to OPRK1 protein
Morphine inhibits the reaction [Zymosan results in decreased expression of OPRK1 mRNA]		 CTD PMID:7562497 PMID:15979727 PMID:18385270 PMID:22661197 PMID:26476280 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823 		JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO [J 113397 binds to and results in decreased activity of OPRL1 protein] which affects the susceptibility to Morphine CTD PMID:11027224 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
increases phosphorylation
increases activity
decreases expression
affects response to substance
increases expression
affects binding
affects activity
decreases response to substance		 ISO
EXP		 [[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
Morphine results in increased phosphorylation of OPRM1 protein
Morphine results in increased activity of OPRM1 protein
Morphine results in decreased expression of OPRM1 mRNA
OPRM1 affects the susceptibility to Morphine; OPRM1 protein affects the susceptibility to Morphine
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; [phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNA; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; valyl-prolyl-aspartyl-prolyl-arginine inhibits the reaction [Morphine results in increased activity of OPRM1 protein]
Morphine results in increased expression of OPRM1 protein
Morphine binds to OPRM1 protein
OPRM1 affects the activity of Morphine
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which affects the susceptibility to Morphine; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein
OPRM1 exon SNP results in decreased susceptibility to Morphine
Morphine affects the activity of OPRM1 protein		 CTD PMID:7562497 PMID:8884884 PMID:9264103 PMID:10803207 PMID:11106302 More... NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 decreases expression EXP Morphine results in decreased expression of OXCT1 protein CTD PMID:23056601 NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714 		JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression ISO Morphine results in decreased expression of PATJ mRNA CTD PMID:21955143 NCBI chr 5:113,061,985...113,364,807
Ensembl chr 5:113,062,118...113,364,807 		JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor increases expression ISO Morphine results in increased expression of PCSK1N mRNA CTD PMID:20144693 NCBI chr  X:14,580,036...14,583,478
Ensembl chr  X:14,580,038...14,583,566 		JBrowse link
G Pdcd5 programmed cell death 5 increases expression EXP Morphine results in increased expression of PDCD5 protein CTD PMID:23056601 NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:88,305,869...88,311,200 		JBrowse link
G Pde10a phosphodiesterase 10A decreases expression ISO Morphine deficiency results in decreased expression of PDE10A mRNA; Morphine results in decreased expression of PDE10A mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
decreases response to substance		 ISO PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
PDGFB protein results in decreased susceptibility to Morphine		 CTD PMID:21483469 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta increases expression
multiple interactions		 EXP Morphine results in increased expression of PDHB protein
Morphine deficiency affects the reaction [Morphine results in increased expression of PDHB protein]		 CTD PMID:23056601 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500 		JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression EXP Morphine results in decreased expression of PDK1 protein CTD PMID:23056601 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP Morphine results in decreased expression of PDK2 protein CTD PMID:23056601 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085 		JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO Morphine results in decreased expression of PDLIM2 mRNA CTD PMID:21955143 NCBI chr15:45,235,421...45,250,187
Ensembl chr15:45,237,477...45,249,242 		JBrowse link
G Pdyn prodynorphin increases expression
decreases expression
multiple interactions		 ISO
EXP		 Morphine results in increased expression of PDYN protein alternative form
Morphine deficiency results in decreased expression of PDYN mRNA
Morphine results in decreased expression of PDYN mRNA
[Zymosan co-treated with Morphine] results in increased expression of PDYN mRNA; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]		 CTD PMID:15979727 PMID:17401159 PMID:20359526 PMID:27126842 NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334 		JBrowse link
G Penk proenkephalin multiple interactions
decreases expression		 EXP
ISO		 Morphine inhibits the reaction [Formaldehyde results in increased expression of PENK mRNA]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein]
Morphine deficiency results in decreased expression of PENK mRNA		 CTD PMID:7978486 PMID:20568289 PMID:27126842 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Per1 period circadian regulator 1 affects expression EXP Morphine affects the expression of PER1 mRNA CTD PMID:19383088 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431 		JBrowse link
G Per2 period circadian regulator 2 affects response to substance
affects expression		 ISO
EXP		 PER2 protein affects the susceptibility to Morphine
Morphine affects the expression of PER2 mRNA		 CTD PMID:19383088 PMID:20434889 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459 		JBrowse link
G Perm1 PPARGC1 and ESRR induced regulator, muscle 1 multiple interactions
increases expression		 EXP Morphine deficiency affects the reaction [Morphine results in increased expression of PERM1 protein] CTD PMID:23056601 NCBI chr 5:166,800,030...166,805,323
Ensembl chr 5:166,800,030...166,805,323 		JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 decreases expression ISO Morphine results in decreased expression of PHLDB1 mRNA CTD PMID:21955143 NCBI chr 8:45,003,538...45,051,541
Ensembl chr 8:45,003,538...45,051,522 		JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A decreases expression ISO Morphine results in decreased expression of PIGA mRNA CTD PMID:21955143 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:30,042,343...30,055,804 		JBrowse link
G Pknox1 PBX/knotted 1 homeobox 1 increases expression ISO Morphine results in increased expression of PKNOX1 mRNA CTD PMID:21178816 NCBI chr20:9,662,866...9,705,030
Ensembl chr20:9,662,899...9,703,727 		JBrowse link
G Plat plasminogen activator, tissue type affects response to substance ISO PLAT protein affects the susceptibility to Morphine CTD PMID:16619846 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plcb1 phospholipase C beta 1 affects response to substance ISO PLCB1 protein affects the susceptibility to Morphine CTD PMID:16405873 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869 		JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions
increases expression		 EXP Morphine deficiency inhibits the reaction [Morphine results in increased expression of PLCD1 protein] CTD PMID:23056601 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186 		JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO Morphine results in decreased expression of PLCD4 mRNA CTD PMID:21955143 NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453 		JBrowse link
G Plekhg1 pleckstrin homology and RhoGEF domain containing G1 decreases expression ISO Morphine results in decreased expression of PLEKHG1 mRNA CTD PMID:21955143 NCBI chr 1:40,348,684...40,434,063
Ensembl chr 1:40,311,221...40,434,063 		JBrowse link
G Plg plasminogen affects response to substance ISO PLG protein affects the susceptibility to Morphine CTD PMID:16619846 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786 		JBrowse link
G Pllp plasmolipin decreases expression ISO Morphine results in decreased expression of PLLP mRNA CTD PMID:21955143 NCBI chr19:10,315,104...10,335,892
Ensembl chr19:10,315,104...10,335,892 		JBrowse link
G Pnoc prepronociceptin decreases response to substance ISO PNOC protein results in decreased susceptibility to Morphine CTD PMID:17303110 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867 		JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 increases expression ISO Morphine results in increased expression of PNPLA3 mRNA CTD PMID:20144693 NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077 		JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases expression		 ISO
EXP		 [Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form
Morphine deficiency results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
[Zymosan co-treated with Morphine] results in increased expression of POMC mRNA
Morphine results in increased expression of POMC mRNA		 CTD PMID:2846107 PMID:15979727 PMID:20084599 PMID:20144693 PMID:24398105 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppia peptidylprolyl isomerase A increases expression EXP Morphine results in increased expression of PPIA protein CTD PMID:23056601 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601 		JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B affects expression
multiple interactions
increases phosphorylation		 EXP
ISO		 Morphine affects the expression of PPP1R1B protein modified form
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]		 CTD PMID:15287884 PMID:21600884 NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775 		JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha increases expression ISO Morphine deficiency results in increased expression of PPP3R1 mRNA; Morphine results in increased expression of PPP3R1 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr14:91,556,743...91,606,230
Ensembl chr14:91,604,121...91,606,907 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein] CTD PMID:18652891 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein] CTD PMID:18652891 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536 		JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO Morphine results in decreased expression of PRKCD mRNA CTD PMID:21955143 NCBI chr16:5,769,226...5,807,214
Ensembl chr16:5,769,215...5,799,352 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
increases expression		 EXP
ISO		 PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein]
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]
Morphine results in increased expression of PRKCG protein modified form		 CTD PMID:18652891 PMID:20359526 PMID:20568289 PMID:21235400 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP Morphine inhibits the reaction [Formaldehyde results in increased expression of PRKG1 protein] CTD PMID:12620371 NCBI chr 1:228,409,883...229,638,794
Ensembl chr 1:228,408,947...229,639,080 		JBrowse link
G Prl prolactin increases secretion EXP Morphine results in increased secretion of PRL protein CTD PMID:7201058 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062 		JBrowse link
G Prr18 proline rich 18 decreases expression ISO Morphine results in decreased expression of PRR18 mRNA CTD PMID:21955143 NCBI chr 1:52,400,215...52,404,492
Ensembl chr 1:52,400,215...52,404,309 		JBrowse link
G Psma5 proteasome 20S subunit alpha 5 increases expression EXP Morphine results in increased expression of PSMA5 protein CTD PMID:23056601 NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731 		JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 multiple interactions
decreases expression		 EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of PSMD2 protein] CTD PMID:23056601 NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043 		JBrowse link
G Ptdss2 phosphatidylserine synthase 2 increases expression ISO Morphine results in increased expression of PTDSS2 mRNA CTD PMID:20144693 NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
increases expression
multiple interactions		 EXP Morphine results in decreased expression of PTGS1 mRNA
Morphine results in increased expression of PTGS1 mRNA
Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA]		 CTD PMID:15183518 PMID:18706994 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO
EXP		 Morphine results in increased expression of PTGS2 protein
[nimesulide results in decreased activity of PTGS2 protein] which results in increased susceptibility to Morphine
[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]		 CTD PMID:14511336 PMID:16325209 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pvalb parvalbumin decreases expression ISO Morphine results in decreased expression of PVALB mRNA CTD PMID:21955143 NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561 		JBrowse link
G Pycard PYD and CARD domain containing decreases expression ISO Morphine results in decreased expression of PYCARD mRNA CTD PMID:20144693 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Pyy peptide YY increases expression ISO Morphine results in increased expression of PYY mRNA CTD PMID:20144693 NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815 		JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression ISO Morphine results in increased expression of RAB11B mRNA CTD PMID:21178816 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593 		JBrowse link
G Rab3a RAB3A, member RAS oncogene family affects expression ISO Morphine affects the expression of RAB3A protein CTD PMID:16522322 NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase affects response to substance
multiple interactions		 EXP
ISO		 RAF1 protein affects the susceptibility to Morphine
HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]		 CTD PMID:18976650 PMID:21235400 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Ramp3 receptor activity modifying protein 3 decreases expression ISO Morphine results in decreased expression of RAMP3 mRNA CTD PMID:21955143 NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902 		JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit decreases expression ISO Morphine results in decreased expression of RBBP5 mRNA CTD PMID:33891991 NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 ISO
EXP		 Morphine inhibits the reaction [Doxorubicin affects the localization of RELA protein]
Colforsin inhibits the reaction [Morphine results in increased phosphorylation of RELA protein]		 CTD PMID:17542780 PMID:22258905 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Reln reelin decreases expression ISO Morphine results in decreased expression of RELN mRNA CTD PMID:21178816 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
G Rem2 RRAD and GEM like GTPase 2 increases expression ISO Morphine results in increased expression of REM2 mRNA CTD PMID:21955143 NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429 		JBrowse link
G Rgs17 regulator of G-protein signaling 17 multiple interactions ISO Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]; Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr 1:42,222,248...42,324,625
Ensembl chr 1:42,227,070...42,324,609 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression
increases expression		 EXP Morphine results in decreased expression of RGS4 mRNA
Morphine results in increased expression of RGS4 mRNA		 CTD PMID:12270694 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Rgs6 regulator of G-protein signaling 6 increases expression ISO Morphine results in increased expression of RGS6 mRNA CTD PMID:21178816 NCBI chr 6:102,264,451...102,796,311
Ensembl chr 6:102,264,447...102,824,753 		JBrowse link
G Ring1 ring finger protein 1 multiple interactions EXP Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter] CTD PMID:25643298 NCBI chr20:4,830,120...4,833,623
Ensembl chr20:4,830,053...4,833,620 		JBrowse link
G Rph3a rabphilin 3A decreases expression ISO Morphine results in decreased expression of RPH3A mRNA CTD PMID:21955143 NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Morphine results in increased expression of RRM2B mRNA CTD PMID:21178816 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G S100b S100 calcium binding protein B decreases expression ISO Morphine results in decreased expression of S100B mRNA CTD PMID:21955143 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743 		JBrowse link
G Sdc4 syndecan 4 increases expression ISO Morphine deficiency results in increased expression of SDC4 mRNA; Morphine results in increased expression of SDC4 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions
increases expression		 EXP Morphine deficiency affects the reaction [Morphine results in increased expression of SDHA protein] CTD PMID:23056601 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Sell selectin L decreases expression
multiple interactions		 EXP Morphine results in decreased expression of SELL protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]		 CTD PMID:10070497 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Septin7 septin 7 multiple interactions
decreases expression		 EXP Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein] CTD PMID:23056601 NCBI chr 8:23,719,448...23,783,247
Ensembl chr 8:23,716,030...23,783,243 		JBrowse link
G Septin8 septin 8 decreases expression ISO Morphine results in decreased expression of SEPTIN8 mRNA CTD PMID:21955143 NCBI chr10:37,684,639...37,713,704
Ensembl chr10:37,684,639...37,713,174 		JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO Morphine results in decreased expression of SERPINB1A mRNA CTD PMID:21955143 NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102 		JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO Morphine results in decreased expression of SERPINF1 mRNA CTD PMID:21955143 NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646 		JBrowse link
G Serping1 serpin family G member 1 multiple interactions
decreases expression		 EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of SERPING1 protein] CTD PMID:23056601 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034 		JBrowse link
G Sertad4 SERTA domain containing 4 increases expression ISO Morphine results in increased expression of SERTAD4 mRNA CTD PMID:21955143 NCBI chr13:104,360,307...104,371,064
Ensembl chr13:104,360,307...104,370,546 		JBrowse link
G Setd1a SET domain containing 1A, histone lysine methyltransferase affects expression ISO Morphine affects the expression of SETD1A mRNA CTD PMID:33891991 NCBI chr 1:182,386,197...182,411,695
Ensembl chr 1:182,388,060...182,411,090 		JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase affects expression ISO Morphine affects the expression of SETD1B mRNA CTD PMID:33891991 NCBI chr12:33,395,963...33,421,671
Ensembl chr12:33,396,120...33,426,934 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Morphine results in increased expression of SGK1 mRNA CTD PMID:21955143 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283 		JBrowse link
G Shox2 short stature homeobox 2 decreases expression ISO Morphine results in decreased expression of SHOX2 mRNA CTD PMID:21955143 NCBI chr 2:151,217,049...151,227,180
Ensembl chr 2:151,217,552...151,227,143 		JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions EXP Morphine promotes the reaction [SIN3A protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr 8:57,481,539...57,536,195
Ensembl chr 8:57,481,573...57,536,192 		JBrowse link
G Slc17a6 solute carrier family 17 member 6 decreases expression ISO Morphine results in decreased expression of SLC17A6 mRNA CTD PMID:21955143 NCBI chr 1:101,212,489...101,252,543
Ensembl chr 1:101,212,489...101,252,542 		JBrowse link
G Slc17a7 solute carrier family 17 member 7 affects expression ISO Morphine affects the expression of SLC17A7 protein CTD PMID:16522322 NCBI chr 1:95,649,709...95,661,591
Ensembl chr 1:95,649,745...95,661,588 		JBrowse link
G Slc23a2 solute carrier family 23 member 2 decreases expression EXP Morphine results in decreased expression of SLC23A2 mRNA CTD PMID:19418264 NCBI chr 3:119,302,651...119,395,289
Ensembl chr 3:119,302,666...119,460,343 		JBrowse link
G Slc25a46 solute carrier family 25, member 46 multiple interactions
decreases expression		 EXP Morphine deficiency promotes the reaction [Morphine results in decreased expression of SLC25A46 protein] CTD PMID:23056601 NCBI chr18:23,215,954...23,244,917
Ensembl chr18:23,215,962...23,244,314 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 multiple interactions
affects response to substance		 ISO [NNC 711 results in decreased activity of SLC6A1 protein] which affects the susceptibility to Morphine
SLC6A1 protein affects the susceptibility to Morphine		 CTD PMID:14598306 NCBI chr 4:147,448,961...147,482,295
Ensembl chr 4:147,466,965...147,482,293 		JBrowse link
G Slc6a18 solute carrier family 6 member 18 increases expression ISO Morphine results in increased expression of SLC6A18 mRNA CTD PMID:20144693 NCBI chr 1:29,607,288...29,621,925
Ensembl chr 1:29,608,077...29,621,925 		JBrowse link
G Slc6a7 solute carrier family 6 member 7 decreases expression ISO Morphine results in decreased expression of SLC6A7 mRNA CTD PMID:21955143 NCBI chr18:54,448,464...54,467,319
Ensembl chr18:54,448,464...54,467,319 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
increases expression		 ISO Morphine affects the reaction [SMPD1 protein affects the abundance of Ceramides]; Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein] CTD PMID:22825003 NCBI chr 1:159,892,946...159,896,789
Ensembl chr 1:159,892,859...159,896,794 		JBrowse link
G Smpx small muscle protein, X-linked increases expression
multiple interactions		 EXP Morphine results in increased expression of SMPX protein
Morphine deficiency affects the reaction [Morphine results in increased expression of SMPX protein]		 CTD PMID:23056601 NCBI chr  X:37,233,209...37,292,266
Ensembl chr  X:37,234,294...37,276,708 		JBrowse link
G Snca synuclein alpha increases expression EXP Morphine results in increased expression of SNCA mRNA CTD PMID:15183518 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions		 ISO Morphine results in increased expression of SOD2 protein
Saquinavir inhibits the reaction [Morphine results in increased expression of SOD2 protein]		 CTD PMID:14871405 PMID:20564181 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A increases expression ISO Morphine results in increased expression of SOWAHA mRNA CTD PMID:21955143 NCBI chr10:37,641,828...37,645,700
Ensembl chr10:37,643,444...37,645,102 		JBrowse link
G Srf serum response factor increases expression EXP Morphine results in increased expression of SRF mRNA CTD PMID:22454534 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Morphine results in increased expression of SRXN1 mRNA CTD PMID:20144693 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Sst somatostatin increases expression ISO Morphine results in increased expression of SST mRNA CTD PMID:21178816 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173 		JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 increases expression
decreases expression		 ISO Morphine results in increased expression of ST8SIA3 mRNA
Morphine deficiency results in decreased expression of ST8SIA3 mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr18:57,754,349...57,760,839
Ensembl chr18:57,754,347...57,760,839 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Morphine results in increased phosphorylation of STAT3 protein CTD PMID:18385270 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stat6 signal transducer and activator of transcription 6 affects response to substance ISO STAT6 gene SNP affects the susceptibility to Morphine CTD PMID:16103897 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495 		JBrowse link
G Strip2 striatin interacting protein 2 increases expression
decreases expression		 ISO Morphine results in increased expression of STRIP2 mRNA
Morphine deficiency results in decreased expression of STRIP2 mRNA		 CTD PMID:21955143 PMID:27126842 NCBI chr 4:58,536,034...58,578,279
Ensembl chr 4:58,536,055...58,578,291 		JBrowse link
G Stx12 syntaxin 12 increases expression EXP Morphine results in increased expression of STX12 mRNA CTD PMID:15183518 NCBI chr 5:145,062,978...145,092,423
Ensembl chr 5:145,063,587...145,092,377 		JBrowse link
G Stx5 syntaxin 5 increases expression EXP Morphine results in increased expression of STX5A mRNA CTD PMID:15183518 NCBI chr 1:205,637,401...205,653,563
Ensembl chr 1:205,637,413...205,653,563 		JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha decreases expression EXP Morphine results in decreased expression of SUCLG1 protein CTD PMID:23056601 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600 		JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit multiple interactions
increases expression		 EXP
ISO		 Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]
Morphine results in increased expression of SUZ12 mRNA		 CTD PMID:25643298 PMID:33891991 NCBI chr10:64,967,035...65,012,916
Ensembl chr10:64,966,967...65,012,738 		JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 increases expression ISO Morphine results in increased expression of SYNE1 mRNA CTD PMID:21955143 NCBI chr 1:41,512,146...41,983,382
Ensembl chr 1:41,512,030...41,983,322 		JBrowse link
G Syt5 synaptotagmin 5 increases expression ISO Morphine results in increased expression of SYT5 mRNA CTD PMID:21178816 NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067 		JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO Morphine results in decreased expression of SYT9 mRNA CTD PMID:21955143 NCBI chr 1:161,275,882...161,456,384
Ensembl chr 1:161,275,734...161,455,007 		JBrowse link
G Tac1 tachykinin, precursor 1 increases expression
multiple interactions		 ISO
EXP		 Morphine deficiency results in increased expression of TAC1 mRNA; Morphine results in increased expression of TAC1 mRNA
Morphine results in increased expression of TAC1 protein
Morphine promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein]		 CTD PMID:11976266 PMID:15964684 PMID:21178816 PMID:27126842 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178 		JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions
decreases expression
increases expression		 EXP [SR 140333 binds to and results in decreased activity of TACR1 protein] which results in increased susceptibility to Morphine; substance P-saporin inhibits the reaction [Morphine results in increased expression of TACR1 protein]
Morphine results in decreased expression of TACR1 protein		 CTD PMID:14511336 PMID:15964684 PMID:17123731 PMID:19428329 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733 		JBrowse link
G Tacr2 tachykinin receptor 2 decreases expression EXP Morphine results in decreased expression of TACR2 protein CTD PMID:19428329 NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446 		JBrowse link
G