opioid agent - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	opioid agent	go back to main search page
Accession:	CHEBI:60598	browse the term
Definition:	Any agent that acts on an opioid receptor or affects the life cycle of an opioid transmitter.
Synonyms:	related_synonym:	opioid agents

show annotations for term's descendants Sort by:
Rat (733) Mouse (731) Human (737) Chinchilla (0) Bonobo (0) Dog (3) Squirrel (0) Pig (3) Green Monkey (0) Naked Mole-rat (0) All
Genes (733)

(R,R)-tramadol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1A

increases expression

Tramadol results in increased expression of ADRA1A protein

NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500

G

alkaline phosphatase, biomineralization associated

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein]

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

BCL2 associated X, apoptosis regulator

increases expression

Tramadol results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

decreases activity

Tramadol results in decreased activity of BCHE protein

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

caspase 3

affects activity
multiple interactions
increases expression
decreases activity

Tramadol affects the activity of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein

PMID:27317026 PMID:28499616 PMID:31618080

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

decreases expression
multiple interactions

Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]

PMID:25550769 PMID:31618080

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

creatine kinase B

decreases expression
multiple interactions

Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

PMID:27317026 PMID:33645892

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, M-type

multiple interactions

Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases activity

Tramadol results in decreased activity of CYP17A1 protein

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing

CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol

PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

desmin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of DES protein]

NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699

G

dopamine receptor D2

increases expression

Tramadol results in increased expression of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D3

increases expression

Tramadol results in increased expression of DRD3 protein

NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596

G

gap junction protein, alpha 1

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein]

NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582

G

glutamic-oxaloacetic transaminase 1

multiple interactions
increases expression

Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

increases activity
multiple interactions
increases expression

Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]

PMID:28689766 PMID:31618080

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

5-hydroxytryptamine receptor 2A

increases activity
increases expression
multiple interactions

Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]

NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928

G

interferon gamma

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

lactate dehydrogenase A

decreases expression

Tramadol results in decreased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

NADH:ubiquinone oxidoreductase core subunit S1

decreases expression

Tramadol results in decreased expression of NDUFS1 mRNA

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

opioid receptor, delta 1

affects binding
multiple interactions

Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding
multiple interactions

Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

affects binding
multiple interactions

Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

pyruvate dehydrogenase kinase 3

increases expression

Tramadol results in increased expression of PDK3 mRNA

NCBI chr X:58,486,699...58,553,533
Ensembl chr X:58,486,554...58,553,557

G

prodynorphin

decreases expression

Tramadol results in decreased expression of PDYN mRNA

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

protein kinase AMP-activated catalytic subunit alpha 1

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase AMP-activated catalytic subunit alpha 2

multiple interactions

[Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA

NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543

G

solute carrier family 2 member 4

multiple interactions

Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 47 member 1

multiple interactions

Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637

G

solute carrier family 47 member 2

multiple interactions

Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]

NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904

G

superoxide dismutase 1

decreases expression
multiple interactions

Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]

PMID:25550769 PMID:31618080

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
decreases expression

Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein]

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

tumor necrosis factor

multiple interactions
increases expression

[Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein]

PMID:17377112 PMID:31618080 PMID:33645892

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

troponin I3, cardiac type

multiple interactions
increases expression

Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

vimentin

multiple interactions

Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

alfentanil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome b5 type A

multiple interactions

CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]; CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]

NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing
multiple interactions

CYP3A4 protein affects the metabolism of Alfentanil
CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]

PMID:15557344 PMID:15731592

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
affects metabolic processing

CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]

PMID:15557344 PMID:15731592 PMID:17554244

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

5-hydroxytryptamine receptor 3A

affects activity

Alfentanil affects the activity of HTR3A protein

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

buprenorphine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

brain-derived neurotrophic factor

decreases expression

Buprenorphine results in decreased expression of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

catalase

decreases activity
multiple interactions

Buprenorphine results in decreased activity of CAT protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein

PMID:25683329 PMID:32113805

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cAMP responsive element binding protein 1

decreases phosphorylation

Buprenorphine results in decreased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome P450, family 2, subfamily c, polypeptide 79

affects metabolic processing

CYP2C8 protein affects the metabolism of Buprenorphine

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases metabolic processing
decreases activity

CYP2D6 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing
decreases alkylation
increases metabolic processing
decreases activity

CYP3A4 protein affects the metabolism of Buprenorphine
CYP3A4 protein results in decreased alkylation of Buprenorphine
CYP3A4 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP3A4 protein

PMID:12756210 PMID:15966752 PMID:16010532

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

glutamic--pyruvic transaminase

increases activity

Buprenorphine results in increased activity of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interleukin 2

decreases expression

Buprenorphine results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

increases expression

Buprenorphine results in increased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

mitogen activated protein kinase 1

increases phosphorylation

Buprenorphine results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Buprenorphine results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

neurotrophic receptor tyrosine kinase 2

decreases phosphorylation

Buprenorphine results in decreased phosphorylation of NTRK2 protein

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

opioid receptor, delta 1

affects binding
multiple interactions

Buprenorphine binds to OPRD1 protein
Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]

PMID:7562497 PMID:21866885

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding
multiple interactions

Buprenorphine binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]

PMID:7562497 PMID:21866885

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid related nociceptin receptor 1

multiple interactions

Buprenorphine binds to and results in increased activity of OPRL1 protein

NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920

G

opioid receptor, mu 1

multiple interactions
affects binding

Buprenorphine binds to and affects the activity of OPRM1 protein; Buprenorphine binds to and results in increased activity of OPRM1 protein; Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]
Buprenorphine binds to OPRM1 protein

PMID:7562497 PMID:16010532 PMID:21866885

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

protein kinase cAMP-activated catalytic subunit alpha

decreases activity

Buprenorphine results in decreased activity of PRKACA protein

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

G

UDP glucuronosyltransferase family 1 member A1

increases glucuronidation

UGT1A1 protein results in increased glucuronidation of Buprenorphine

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

butorphanol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

opioid receptor, delta 1

affects activity

Butorphanol affects the activity of OPRD1 protein

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects activity

Butorphanol affects the activity of OPRK1 protein

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

affects activity
increases activity

Butorphanol affects the activity of OPRM1 protein
Butorphanol results in increased activity of OPRM1 protein

PMID:17909753 PMID:32734307

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

protein kinase C, delta

affects localization

Butorphanol affects the localization of PRKCD protein

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

carfentanil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450, family 2, subfamily c, polypeptide 79

increases metabolic processing

CYP2C8 protein results in increased metabolism of carfentanil

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing

CYP3A4 protein results in increased metabolism of carfentanil

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 9

increases metabolic processing

CYP3A5 protein results in increased metabolism of carfentanil

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

opioid receptor, mu 1

multiple interactions

Capsaicin inhibits the reaction [carfentanil binds to OPRM1 protein]; Cocaine affects the reaction [carfentanil binds to OPRM1 protein]

PMID:12406535 PMID:15953495

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

codeine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-C motif chemokine ligand 2

increases secretion

Codeine results in increased secretion of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions

Codeine affects the secretion of and affects the expression of CCL5 protein

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

carboxylesterase 2H

increases hydrolysis

CES2 protein results in increased hydrolysis of Codeine analog

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance
decreases methylation

CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine
[CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
[CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CYP2D6 protein polymorphism affects the susceptibility to Codeine
CYP2D6 protein results in decreased methylation of Codeine
CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine

PMID:9696456 PMID:10911933 PMID:11823760 PMID:15286053 PMID:15625333 More...

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing
increases metabolic processing
multiple interactions

CYP3A4 protein affects the metabolism of Codeine
CYP3A4 protein results in increased metabolism of Codeine
[CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine

PMID:15286053 PMID:16595712

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Codeine results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

opioid receptor, delta 1

affects binding

Codeine binds to OPRD1 protein

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding

Codeine binds to OPRK1 protein

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

affects binding

Codeine binds to OPRM1 protein

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

codeinone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression

6-codeinone results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

6-codeinone results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

increases activity
increases cleavage

6-codeinone results in increased activity of CASP3 protein
6-codeinone results in increased cleavage of CASP3 protein

PMID:12606908 PMID:12894543

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases activity

6-codeinone results in increased activity of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cytochrome c, somatic

affects localization

6-codeinone affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

dextropropoxyphene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

affects response to substance

ABCB1A protein affects the susceptibility to Dextropropoxyphene

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects response to substance

ABCB1B protein affects the susceptibility to Dextropropoxyphene

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

carboxylesterase 1D

affects binding

Dextropropoxyphene binds to CES1 protein

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2H

affects binding

Dextropropoxyphene binds to CES2 protein

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

opioid receptor, delta 1

multiple interactions
affects binding

[Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

multiple interactions
affects binding

[Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

multiple interactions
affects binding

[Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

solute carrier family 22 member 2

multiple interactions

Dextropropoxyphene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

DPDPE

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

affects export

ABCC2 protein affects the export of Enkephalin, D-Penicillamine (2,5)-

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

cholecystokinin B receptor

affects response to substance

CCKBR protein affects the susceptibility to Enkephalin, D-Penicillamine (2,5)-

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

hepatocyte nuclear factor 4, alpha

increases secretion

HNF4A protein results in increased secretion of Enkephalin, D-Penicillamine (2,5)-

NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320

G

opioid receptor, delta 1

multiple interactions
affects binding
increases expression

[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum; [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]
7-hydroxymitragynine affects the reaction [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein]; Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]; Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein
Enkephalin, D-Penicillamine (2,5)- binds to OPRD1 protein
Enkephalin, D-Penicillamine (2,5)- results in increased expression of OPRD1 mRNA

PMID:7477890 PMID:7562497 PMID:9302088 PMID:19279569 PMID:21866885 More...

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding

Enkephalin, D-Penicillamine (2,5)- binds to OPRK1 protein

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

affects binding

Enkephalin, D-Penicillamine (2,5)- binds to OPRM1 protein

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

solute carrier organic anion transporter family, member 1a4

affects transport
affects uptake

SLCO1A4 protein affects the transport of Enkephalin, D-Penicillamine (2,5)-
SLCO1A4 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)-

PMID:15528320 PMID:19833843

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family member 1B2

affects uptake

SLCO1B2 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)-

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

eluxadoline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

opioid receptor, delta 1

affects response to substance

OPRD1 protein affects the susceptibility to eluxadoline

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

fentanyl

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport
multiple interactions
increases response to substance

ABCB1 protein results in increased transport of Fentanyl
tariquidar inhibits the reaction [ABCB1 protein results in increased transport of Fentanyl]
ABCB1 protein results in increased susceptibility to Fentanyl

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

arrestin, beta 2

affects localization
multiple interactions

Fentanyl affects the localization of ARRB2 protein
[Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein

PMID:27030709 PMID:35477798

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

calcitonin-related polypeptide alpha

multiple interactions

Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

corticotropin releasing hormone

affects expression

Fentanyl affects the expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases activity

Fentanyl results in increased activity of CYP2B6 protein

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases metabolic processing

CYP3A4 protein results in increased metabolism of Fentanyl

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Fentanyl results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

gastrin

multiple interactions

[fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine]

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

interleukin 2

decreases expression

Fentanyl results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

increases expression

Fentanyl results in increased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

potassium voltage-gated channel subfamily H member 2

decreases activity

Fentanyl results in decreased activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

mitogen activated protein kinase 1

increases phosphorylation

Fentanyl results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Fentanyl results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NFKB inhibitor alpha

increases expression

Fentanyl results in increased expression of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

opioid receptor, delta 1

affects binding

Fentanyl binds to OPRD1 protein

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding

Fentanyl binds to OPRK1 protein

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

increases phosphorylation
multiple interactions

Fentanyl results in increased phosphorylation of OPRM1 protein
[Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Fentanyl binds to and results in increased activity of OPRM1 protein

PMID:17240843 PMID:21957251 PMID:23300227 PMID:35477798

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

prodynorphin

increases expression

Fentanyl results in increased expression of PDYN protein

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

phospholipase D2

increases activity

Fentanyl results in increased activity of PLD2 protein

NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808

G

proopiomelanocortin

decreases expression
multiple interactions

Fentanyl results in decreased expression of POMC protein alternative form
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

renin

multiple interactions

[Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein

NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489

heroin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
increases metabolic processing

[ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

actinin alpha 2

decreases expression

Heroin results in decreased expression of ACTN2 mRNA

NCBI chr17:58,143,334...58,210,622
Ensembl chr17:58,142,625...58,210,622

G

amphiphysin

decreases expression

Heroin results in decreased expression of AMPH mRNA

NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315

G

amyloid beta precursor protein

decreases expression

Heroin results in decreased expression of APP mRNA

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

butyrylcholinesterase

multiple interactions
increases metabolic processing

[BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

brain-derived neurotrophic factor

decreases expression
multiple interactions

Heroin results in decreased expression of BDNF protein
Heroin results in decreased expression of BDNF mRNA
Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]

PMID:17715210 PMID:25643298

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

biogenesis of lysosomal organelles complex 1 subunit 6

decreases expression

Heroin results in decreased expression of BLOC1S6 mRNA

NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:109,816,366...109,828,308

G

caspase 3

multiple interactions

[Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

carboxylesterase 1D

decreases acetylation
increases hydrolysis
multiple interactions
affects binding

CES1 protein results in decreased acetylation of Heroin
CES1 protein results in increased hydrolysis of Heroin
Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
Heroin binds to CES1 protein

PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2H

multiple interactions
increases hydrolysis

Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin]

PMID:8930175 PMID:9169443 PMID:25445008

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

churchill domain containing 1

decreases expression

Heroin results in decreased expression of CHURC1 mRNA

NCBI chr 6:95,464,488...95,485,208
Ensembl chr 6:95,470,683...95,619,586

G

cAMP responsive element binding protein 1

multiple interactions
increases phosphorylation

Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
heroin increases phosphorylation of Creb1 protein in brain

CTD
RGD

PMID:25643298 PMID:21362452

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

Heroin results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases activity

Heroin results in increased activity of CYP2B6 protein

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases activity

Heroin results in increased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

DEAF1 transcription factor

decreases expression

Heroin results in decreased expression of DEAF1 mRNA

NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:196,401,857...196,435,541

G

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

Heroin results in decreased expression of DNPH1 mRNA

NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022

G

dopamine receptor D2

decreases expression

Heroin results in decreased expression of DRD2 protein

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

eukaryotic translation initiation factor 5A

decreases expression

Heroin results in decreased expression of EIF5A mRNA

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

energy homeostasis associated

decreases expression

Heroin results in decreased expression of ENHO mRNA

NCBI chr 5:56,800,980...56,802,777
Ensembl chr 5:56,800,980...56,802,777

G

Fas cell surface death receptor

increases expression

Heroin results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein
Dronabinol affects the reaction [Heroin results in increased expression of FOS protein]

PMID:16137723 PMID:19169671

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

decreases expression

heroin decreases expression of Fosb protein in brain

RGD

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

glutamic--pyruvic transaminase

increases expression

Heroin results in increased expression of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interferon gamma

multiple interactions

[Cocaine co-treated with Heroin] results in increased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 10

multiple interactions

[Cocaine co-treated with Heroin] results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 2

multiple interactions

[Cocaine co-treated with Heroin] results in increased expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

multiple interactions

[Cocaine co-treated with Heroin] results in increased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

integrin subunit beta 1 binding protein 1

increases expression

Heroin results in increased expression of ITGB1BP1 mRNA

NCBI chr 6:40,820,693...40,836,074
Ensembl chr 6:40,821,339...40,836,037

G

nerve growth factor

decreases expression

Heroin results in decreased expression of NGF protein

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nuclear receptor subfamily 4, group A, member 2

decreases expression

Heroin results in decreased expression of NR4A2 mRNA

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

neurotrophic receptor tyrosine kinase 2

increases expression

Heroin results in increased expression of NTRK2 mRNA

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

G

nuclear casein kinase and cyclin-dependent kinase substrate 1

decreases expression

Heroin results in decreased expression of NUCKS1 mRNA

NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229

G

phosphodiesterase 4D interacting protein

increases expression

Heroin results in increased expression of PDE4DIP mRNA

NCBI chr 2:185,293,236...185,490,100
Ensembl chr 2:185,293,214...185,468,379

G

prodynorphin

decreases expression
increases expression

Heroin results in decreased expression of PDYN mRNA
Heroin results in increased expression of PDYN mRNA

PMID:16710320 PMID:19100723

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

prostate transmembrane protein, androgen induced 1

decreases expression

Heroin results in decreased expression of PMEPA1 mRNA

NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454

G

prolyl endopeptidase-like

decreases expression

Heroin results in decreased expression of PREPL mRNA

NCBI chr 6:9,580,367...9,609,957
Ensembl chr 6:9,580,217...9,607,772

G

septin 4

increases expression

Heroin results in increased expression of SEPTIN4 mRNA

NCBI chr10:72,366,729...72,390,764
Ensembl chr10:72,366,873...72,390,768

G

solute carrier family 25 member 23

decreases expression

Heroin results in decreased expression of SLC25A23 mRNA

NCBI chr 9:1,882,636...1,898,369
Ensembl chr 9:1,882,621...1,898,561

G

solute carrier family 25 member 37

increases expression

Heroin results in increased expression of SLC25A37 mRNA

NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199

G

synaptosome associated protein 25

decreases expression

Heroin results in decreased expression of SNAP25 mRNA

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

syntaxin binding protein 1

decreases expression

Heroin results in decreased expression of STXBP1 mRNA

NCBI chr 3:16,076,725...16,138,431
Ensembl chr 3:16,076,391...16,138,369

G

syntaxin binding protein 6

decreases expression

Heroin results in decreased expression of STXBP6 mRNA

NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:61,920,756...62,158,024

G

synaptic vesicle glycoprotein 2a

decreases expression

Heroin results in decreased expression of SV2A mRNA

NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:183,741,547...183,756,927

G

synaptogyrin 3

decreases expression

Heroin results in decreased expression of SYNGR3 mRNA

NCBI chr10:13,710,553...13,715,309
Ensembl chr10:13,704,998...13,715,669

G

synaptotagmin 1

decreases expression

Heroin results in decreased expression of SYT1 mRNA

NCBI chr 7:43,813,204...44,358,020
Ensembl chr 7:43,815,785...44,357,803

G

transferrin receptor

increases expression

Heroin results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

tumor necrosis factor

multiple interactions

[Cocaine co-treated with Heroin] results in increased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

UDP-glucose ceramide glucosyltransferase

decreases expression

Heroin results in decreased expression of UGCG mRNA

NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393

G

vesicle transport through interaction with t-SNAREs 1B

decreases expression

Heroin results in decreased expression of VTI1B mRNA

NCBI chr 6:97,957,700...97,976,491
Ensembl chr 6:97,961,346...97,976,465

hydrocodone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

opioid receptor, delta 1

affects binding

Hydrocodone binds to OPRD1 protein

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding

Hydrocodone binds to OPRK1 protein

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

affects binding

Hydrocodone binds to OPRM1 protein

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

hydromorphone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arrestin, beta 2

multiple interactions

[Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

5-hydroxytryptamine receptor 3A

affects activity

Hydromorphone affects the activity of HTR3A protein

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

G

opioid receptor, mu 1

increases activity
multiple interactions

Hydromorphone results in increased activity of OPRM1 protein
[Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Hydromorphone binds to and results in increased activity of OPRM1 protein

PMID:32734307 PMID:35449307 PMID:35477798

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

Leu-enkephalin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dipeptidylpeptidase 3

increases cleavage
multiple interactions

DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]

NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541

G

opioid receptor, delta 1

increases activity

Enkephalin, Leucine results in increased activity of OPRD1 protein

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, mu 1

increases activity

Enkephalin, Leucine results in increased activity of OPRM1 protein

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

loperamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

decreases expression

Loperamide results in decreased expression of ABCB11 mRNA

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

affects binding
decreases expression
multiple interactions
increases transport
affects response to substance

Loperamide binds to ABCB1 protein
Loperamide results in decreased expression of ABCB1 mRNA
Loperamide inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]
ABCB1 protein results in increased transport of Loperamide
ABCB1A protein affects the susceptibility to Loperamide

PMID:15502009 PMID:23976943 PMID:34719826

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects response to substance

ABCB1B protein affects the susceptibility to Loperamide

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 2

decreases expression

Loperamide results in decreased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 5

decreases expression

Loperamide results in decreased expression of ABCG5 mRNA

NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563

G

anoctamin 1

decreases expression
multiple interactions

Loperamide results in decreased expression of ANO1 mRNA; Loperamide results in decreased expression of ANO1 protein
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]

NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

Loperamide promotes the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]
Loperamide results in decreased expression of BCL2 mRNA

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

catalase

decreases expression

Loperamide results in decreased expression of CAT protein

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

Loperamide results in increased expression of CDKN1A mRNA
Loperamide promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

carboxylesterase 2H

decreases activity
multiple interactions

Loperamide results in decreased activity of CES2 protein
[Loperamide results in decreased activity of CES2 protein] which results in increased susceptibility to Bisphenol A-Glycidyl Methacrylate

PMID:15687373 PMID:21951919 PMID:28647665

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cholesterol 25-hydroxylase

increases expression

Loperamide results in increased expression of CH25H mRNA

NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195

G

creatine kinase B

multiple interactions

Loperamide results in increased secretion of [CKM protein binds to CKB protein]

NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315

G

creatine kinase, M-type

multiple interactions

Loperamide results in increased secretion of [CKM protein binds to CKB protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

[Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450 family 7 subfamily A member 1

increases expression

Loperamide results in increased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

fatty acid binding protein 6

increases expression

Loperamide results in increased expression of FABP6 mRNA

NCBI chr10:28,063,603...28,068,276
Ensembl chr10:28,063,603...28,068,282

G

farnesyl diphosphate synthase

increases expression

Loperamide results in increased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

glutamic-oxaloacetic transaminase 1

increases secretion

Loperamide results in increased secretion of GOT1 protein

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression

Loperamide results in increased expression of HMGCR mRNA

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

5-hydroxytryptamine receptor 4

multiple interactions
decreases expression

Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA]

NCBI chr18:55,765,981...55,949,921
Ensembl chr18:55,766,725...55,949,321

G

isopentenyl-diphosphate delta isomerase 1

increases expression

Loperamide results in increased expression of IDI1 mRNA

NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357

G

interleukin 2

decreases expression

Loperamide results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

increases expression

Loperamide results in increased expression of IL4 mRNA

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

lanosterol synthase

increases expression

Loperamide results in increased expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

mitogen activated protein kinase 1

increases phosphorylation

Loperamide results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Loperamide results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

decreases expression
multiple interactions

Loperamide results in decreased expression of MAPK8 mRNA
Loperamide promotes the reaction [Doxorubicin results in decreased expression of MAPK8 mRNA]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mechanistic target of rapamycin kinase

multiple interactions
decreases expression

Loperamide promotes the reaction [Doxorubicin results in decreased expression of MTOR mRNA]
Loperamide results in decreased expression of MTOR mRNA

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mevalonate kinase

increases expression

Loperamide results in increased expression of MVK mRNA

NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882

G

myosin light chain kinase

decreases expression
multiple interactions

Loperamide results in decreased expression of MYLK mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

NFKB inhibitor alpha

increases expression

Loperamide results in increased expression of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 1

multiple interactions
decreases expression

Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of NOS1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of NOS1 protein]

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions

[Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

nuclear receptor subfamily 1, group I, member 3

multiple interactions

[Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Loperamide binds to and results in decreased activity of NR1I3 protein alternative form

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

opioid receptor, delta 1

affects response to substance

OPRD1 protein affects the susceptibility to Loperamide

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

phospholipase D2

increases activity

Loperamide results in increased activity of PLD2 protein

NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808

G

ryanodine receptor 3

decreases expression
multiple interactions

Loperamide results in decreased expression of RYR3 mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]

NCBI chr 3:99,431,755...99,979,125
Ensembl chr 3:99,432,505...99,704,961

G

solute carrier family 22 member 2

multiple interactions

Loperamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 51 member A

increases expression

Loperamide results in increased expression of SLC51A mRNA

NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485

G

squalene epoxidase

increases expression

Loperamide results in increased expression of SQLE mRNA

NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618

G

troponin I3, cardiac type

increases secretion

Loperamide results in increased secretion of TNNI3 protein

NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580

G

transient receptor potential cation channel, subfamily M, member 7

multiple interactions
decreases expression

Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of TRPM7 protein]

NCBI chr 3:114,046,258...114,134,799
Ensembl chr 3:114,046,258...114,135,190

methadone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases expression
affects activity

Methadone results in increased expression of ABCB1 protein
Methadone affects the activity of ABCB1 protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP-binding cassette, sub-family B member 1B

affects activity
increases expression

Methadone affects the activity of ABCB1B protein
Methadone results in increased expression of ABCB1B protein

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

BCL2 associated X, apoptosis regulator

affects localization

Methadone affects the localization of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

C-C motif chemokine ligand 2

increases secretion

Methadone results in increased secretion of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

increases secretion

Methadone results in increased secretion of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-X3-C motif chemokine ligand 1

increases secretion

Methadone results in increased secretion of CX3CL1 protein

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 1

increases secretion

Methadone results in increased secretion of CXCL1 protein

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

cytochrome c, somatic

affects localization

Methadone affects the localization of CYCS protein

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
affects metabolic processing

Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 2, subfamily d, polypeptide 4

increases metabolic processing
decreases activity

CYP2D22 protein results in increased metabolism of Methadone
Methadone results in decreased activity of CYP2D6 protein

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 3, subfamily a, polypeptide 2

affects metabolic processing
increases metabolic processing

CYP3A4 protein affects the metabolism of Methadone
CYP3A4 protein results in increased metabolism of Methadone

PMID:15986265 PMID:16595712

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dopamine receptor D2

multiple interactions

Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA]

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

hypocretin neuropeptide precursor

multiple interactions

Methadone affects the reaction [Cocaine affects the expression of HCRT mRNA]

NCBI chr10:85,689,979...85,691,214
Ensembl chr10:85,689,465...85,691,210

G

interleukin 10

increases secretion

Methadone results in increased secretion of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

increases expression

Methadone results in increased expression of IL1A protein

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases secretion
increases expression

Methadone results in increased secretion of IL1B protein
Methadone results in increased expression of IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases expression

Methadone results in decreased expression of IL2 mRNA

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

increases expression
multiple interactions

Methadone results in increased expression of IL4 mRNA; Methadone results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression
increases secretion

Methadone results in increased expression of IL6 mRNA; Methadone results in increased expression of IL6 protein
Methadone results in increased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 2

decreases response to substance

Methadone results in decreased susceptibility to INS protein

NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775

G

potassium voltage-gated channel subfamily H member 2

multiple interactions
decreases activity

Chlorobutanol promotes the reaction [Methadone results in decreased activity of KCNH2 protein]

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

leptin

increases expression

Methadone results in increased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

mitogen activated protein kinase 1

increases phosphorylation

Methadone results in increased phosphorylation of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

increases phosphorylation

Methadone results in increased phosphorylation of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NFKB inhibitor alpha

increases expression

Methadone results in increased expression of NFKBIA protein

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

opioid receptor, delta 1

affects binding
multiple interactions

Methadone binds to OPRD1 protein
[Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects binding
multiple interactions

Methadone binds to OPRK1 protein
[Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid receptor, mu 1

multiple interactions
affects binding

[Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

phospholipase D2

increases activity

Methadone results in increased activity of PLD2 protein

NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808

G

prolactin

affects secretion
increases secretion
increases expression

Methadone affects the secretion of PRL protein
Methadone results in increased secretion of PRL protein
Methadone results in increased expression of PRL protein

PMID:2554359 PMID:16675813 PMID:21094671

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

toll-like receptor 4

affects binding
increases expression
affects response to substance
multiple interactions

Methadone binds to TLR4 protein
Methadone results in increased expression of TLR4 mRNA; Methadone results in increased expression of TLR4 protein
Methadone affects the susceptibility to TLR4 protein
Naloxone affects the reaction [Methadone binds to TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

increases secretion
increases expression

Methadone results in increased secretion of TNF protein
Methadone results in increased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

morphine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

affects metabolic processing
multiple interactions

ABCB1 affects the metabolism of Morphine
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA

PMID:23748253 PMID:26554626

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily G member 2

multiple interactions

[Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

ankyrin repeat and BTB domain containing 3

decreases expression

Morphine results in decreased expression of ABTB3 mRNA

NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834

G

acetyl-CoA acetyltransferase 1

decreases expression
multiple interactions

Morphine results in decreased expression of ACAT1 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of ACAT1 protein]

NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855

G

acetylcholinesterase

multiple interactions
increases chemical synthesis

[ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
ACHE protein results in increased chemical synthesis of Morphine

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

adenylate cyclase 1

multiple interactions

[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine

NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969

G

adenylate cyclase 6

affects expression

Morphine affects the expression of ADCY6 mRNA

NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754

G

adenylate cyclase 8

affects response to substance
affects expression
multiple interactions

ADCY8 protein affects the susceptibility to Morphine
Morphine affects the expression of ADCY8 mRNA
[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine

PMID:15829634 PMID:16914643

NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911

G

adhesion G protein-coupled receptor A1

decreases expression

Morphine results in decreased expression of ADGRA1 mRNA

NCBI chr 1:194,629,744...194,673,254
Ensembl chr 1:194,629,726...194,672,550

G

adenosine A1 receptor

affects response to substance
increases expression
multiple interactions

ADORA1 protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA1 mRNA; Morphine results in increased expression of ADORA1 protein
[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein

PMID:9407998 PMID:26478469

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

adenosine A2a receptor

affects response to substance
increases expression

ADORA2A protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA2A mRNA

PMID:14756803 PMID:21955143

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adrenoceptor alpha 2A

increases expression

morphine increases expression of Adra2a mRNA in cerebral cortex

RGD

NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365

G

agouti related neuropeptide

increases expression

Morphine results in increased expression of AGRP mRNA

NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584

G

allograft inflammatory factor 1

multiple interactions
increases expression

[lead acetate co-treated with Morphine] results in increased expression of AIF1 mRNA
corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of AIF1 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]

PMID:26478469 PMID:37394652

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

adenylate kinase 5

decreases expression

Morphine results in decreased expression of AK5 mRNA

NCBI chr 2:241,397,297...241,581,483
Ensembl chr 2:241,397,297...241,581,458

G

aldo-keto reductase family 1 member B1

decreases expression

Morphine results in decreased expression of AKR1B1 protein

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

G

AKT serine/threonine kinase 1

multiple interactions
increases expression
decreases expression

ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]
Morphine results in increased expression of AKT1 protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form]

PMID:19239323 PMID:20600172

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions
decreases expression

Morphine deficiency inhibits the reaction [Morphine results in decreased expression of ALB protein]

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

anoctamin 3

increases expression

Morphine results in increased expression of ANO3 mRNA

NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:97,238,354...97,550,154

G

annexin A6

decreases expression

Morphine results in decreased expression of ANXA6 protein

NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433

G

apolipoprotein A1

increases expression

Morphine results in increased expression of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein B

increases expression

Morphine results in increased expression of APOB protein

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

apolipoprotein E

increases expression
multiple interactions

Morphine results in increased expression of APOE protein
Morphine deficiency affects the reaction [Morphine results in increased expression of APOE protein]

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

aquaporin 1

increases expression

Morphine results in increased expression of AQP1 mRNA

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 3 (Gill blood group)

increases expression

Morphine results in increased expression of AQP3 mRNA; Morphine results in increased expression of AQP3 protein

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

aquaporin 4

decreases expression

Morphine results in decreased expression of AQP4 mRNA

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

G

activity-regulated cytoskeleton-associated protein

increases expression

morphine increases expression in Arc protein in nucleus accumbens
morphine increases expression of Arc mRNA in prefrontal cortex
morphine co-treated with naloxone increases expression of Arc protein in brain
Morphine increases expression of Arc protein in shell of nucleus accumbens

RGD

PMID:21549764 PMID:30550948 PMID:19262551 PMID:25746394

RGD:401851922, RGD:401959617, RGD:401938601, RGD:11087075

NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378

G

ADP-ribosylation factor like GTPase 4D

increases expression

Morphine results in increased expression of ARL4D mRNA

NCBI chr10:86,592,054...86,602,843
Ensembl chr10:86,595,661...86,602,836

G

ADP-ribosylation factor like GTPase 6 interacting protein 5

multiple interactions
increases expression

ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine results in increased expression of ARL6IP5 protein
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]

NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:129,810,645...129,838,608

G

cAMP regulated phosphoprotein 21

increases expression
decreases expression

Morphine results in increased expression of ARPP21 mRNA
Morphine deficiency results in decreased expression of ARPP21 mRNA

PMID:21955143 PMID:27126842

NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:112,034,642...112,194,297

G

arrestin, beta 2

affects response to substance
multiple interactions

ARRB2 gene SNP affects the susceptibility to Morphine
[Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein
ARRB2 protein affects the susceptibility to Morphine
[gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]

PMID:16103897 PMID:19239323 PMID:19477204 PMID:23300227 PMID:24063433 More...

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

ADP-ribosyltransferase 3

multiple interactions
increases expression

Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]

NCBI chr14:15,637,230...15,719,442
Ensembl chr14:15,637,237...15,665,407

G

acid sensing ion channel subunit family member 4

increases expression

Morphine results in increased expression of ASIC4 mRNA

NCBI chr 9:76,941,532...76,962,900
Ensembl chr 9:76,941,532...76,962,900

G

activating transcription factor 4

multiple interactions
increases expression

corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]]

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

Morphine results in decreased expression of ATIC protein

NCBI chr 9:73,164,846...73,184,897
Ensembl chr 9:73,164,846...73,184,889

G

ATRX, chromatin remodeler

increases expression

Morphine results in increased expression of ATRX mRNA

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

arginine vasopressin receptor 1A

decreases expression

Morphine results in decreased expression of AVPR1A mRNA

NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215

G

BAG cochaperone 3

increases expression

Morphine results in increased expression of BAG3 protein

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

BCL2-antagonist/killer 1

increases expression

Morphine results in increased expression of BAK1 protein

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression
decreases expression

[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
Morphine results in increased expression of BAX mRNA; Morphine results in increased expression of BAX protein
Morphine results in decreased expression of BAX mRNA
Lithium inhibits the reaction [Morphine results in increased expression of BAX mRNA]
TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein]

PMID:10534122 PMID:10809959 PMID:12196588 PMID:12702572 PMID:12927789 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

increases expression

Morphine results in increased expression of BBC3 mRNA

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

brain enriched myelin associated protein 1

decreases expression

Morphine results in decreased expression of BCAS1 mRNA

NCBI chr 3:159,136,077...159,219,072
Ensembl chr 3:159,136,083...159,219,106

G

butyrylcholinesterase

increases chemical synthesis
multiple interactions

BCHE protein results in increased chemical synthesis of Morphine
[BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL11 transcription factor B

increases expression
decreases expression

Morphine results in increased expression of BCL11B mRNA
Morphine deficiency results in decreased expression of BCL11B mRNA

PMID:21955143 PMID:27126842

NCBI chr 6:126,834,531...126,927,720
Ensembl chr 6:126,834,531...126,928,224

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]
Morphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 protein
Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]

PMID:10534122 PMID:12196588 PMID:12927789 PMID:17542780 PMID:18976035 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

decreases expression

Morphine results in decreased expression of BCL2L1 mRNA

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

Bcl2-like 11

increases expression

Morphine results in increased expression of BCL2L11 protein

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

G

brain-derived neurotrophic factor

increases expression
increases expression
decreases expression
multiple interactions

Morphine results in increased expression of BDNF mRNA; Morphine results in increased expression of BDNF protein
Morphine increases expression of Bdnf mRNA in ventral tegmental area
Morphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative form
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]
AM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein]; BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]

CTD
RGD

PMID:19033880 PMID:25643298 PMID:27461790 PMID:30550948

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

beclin 1

multiple interactions
increases expression

Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]
Morphine results in increased expression of BECN1 protein

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

brain expressed, X-linked 4

increases expression

Morphine results in increased expression of BEX4 mRNA

NCBI chr X:99,131,985...99,133,417
Ensembl chr X:99,131,942...99,133,531

G

BCL2 family apoptosis regulator BOK

decreases expression

Morphine results in decreased expression of BOK mRNA

NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476

G

complement C1q like 3

increases expression

Morphine results in increased expression of C1QL3 mRNA

NCBI chr17:76,119,344...76,129,170
Ensembl chr17:76,119,447...76,128,530

G

calbindin 1

increases expression

Morphine results in increased expression of CALB1 mRNA

NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431

G

calcitonin-related polypeptide alpha

increases expression
multiple interactions

Morphine results in increased expression of CALCA mRNA; Morphine results in increased expression of CALCA protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]
GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]

PMID:16935424 PMID:20359526 PMID:20568289

NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105

G

calcium/calmodulin-dependent protein kinase II alpha

affects response to substance
increases expression

CAMK2A protein affects the susceptibility to Morphine
Morphine results in increased expression of CAMK2A mRNA

PMID:20053885 PMID:21955143

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

G

cyclase associated actin cytoskeleton regulatory protein 1

decreases expression

Morphine results in decreased expression of CAP1 mRNA

NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769

G

carbonic anhydrase 2

increases expression

Morphine results in increased expression of CAR2 mRNA

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

calcium regulated heat stable protein 1

increases expression

Morphine results in increased expression of CARHSP1 mRNA

NCBI chr10:6,946,036...6,960,556
Ensembl chr10:6,946,959...7,020,019

G

CART prepropeptide

increases expression

Morphine results in increased expression of CARTPT mRNA

NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713

G

caspase 1

decreases expression

Morphine results in decreased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases cleavage
increases activity
increases expression

[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Morphine results in increased activity of and results in increased cleavage of CASP3 protein; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Morphine results in increased cleavage of CASP3 protein
Morphine results in increased expression of CASP3 protein
Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]
corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form]; SB 203580 inhibits the reaction [Morphine results in increased activity of CASP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]
Morphine results in increased expression of CASP3 protein; Morphine results in increased expression of CASP3 protein alternative form

PMID:10534122 PMID:11590188 PMID:12196588 PMID:16102899 PMID:17542780 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions
increases activity
decreases expression

ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
Morphine results in increased activity of CASP8 protein

PMID:11590188 PMID:19070643 PMID:19239323

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
increases expression

Morphine results in increased activity of CASP9 protein
Morphine results in increased expression of CASP9 mRNA

PMID:15183518 PMID:19292871

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

CAT protein inhibits the reaction [Morphine results in increased abundance of Hydrogen Peroxide]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cerebellin 1 precursor

decreases expression

Morphine results in decreased expression of CBLN1 mRNA

NCBI chr19:19,608,763...19,612,572
Ensembl chr19:19,608,716...19,612,572

G

coiled-coil domain containing 136

decreases expression

Morphine results in decreased expression of CCDC136 mRNA

NCBI chr 4:57,997,825...58,027,598
Ensembl chr 4:57,997,853...58,027,646

G

cholecystokinin

decreases expression

Morphine results in decreased expression of CCK mRNA

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

cholecystokinin B receptor

affects response to substance

CCKBR protein affects the susceptibility to Morphine

PMID:11403953 PMID:11880531

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

C-C motif chemokine ligand 2

increases secretion

Morphine results in increased secretion of CCL2 protein

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

increases secretion

Morphine results in increased secretion of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

multiple interactions
decreases expression

beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein]; Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

CD38 molecule

affects response to substance

CD38 affects the susceptibility to Morphine

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

CD79b molecule

increases expression

Morphine results in increased expression of CD79B mRNA

NCBI chr10:91,239,354...91,242,500
Ensembl chr10:91,239,356...91,242,625

G

CD9 molecule

increases expression

Morphine results in increased expression of CD9 protein

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

G

cadherin 22

increases expression

Morphine results in increased expression of CDH22 mRNA

NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

centrosomal protein 83

increases expression

Morphine results in increased expression of CEP83 mRNA

NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:29,280,419...29,389,574

G

carboxylesterase 2H

increases chemical synthesis
multiple interactions

CES2 protein results in increased chemical synthesis of Morphine
Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]

NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830

G

cholinergic receptor, muscarinic 5

affects response to substance

CHRM5 protein affects the susceptibility to Morphine

NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252

G

cold inducible RNA binding protein

increases expression

Morphine results in increased expression of CIRBP mRNA

NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818

G

claudin 2

increases expression

Morphine results in increased expression of CLDN2 mRNA

NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838

G

carboxymethylenebutenolidase homolog

decreases expression

Morphine results in decreased expression of CMBL protein

NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009

G

CKLF-like MARVEL transmembrane domain containing 5

increases expression

Morphine results in increased expression of CMTM5 mRNA

NCBI chr15:28,412,624...28,415,304
Ensembl chr15:28,412,624...28,415,287

G

CCHC-type zinc finger, nucleic acid binding protein

multiple interactions
decreases expression

Morphine deficiency affects the reaction [Morphine results in decreased expression of CNBP protein]

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

cannabinoid receptor 1

multiple interactions
decreases expression
increases expression

[Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
Morphine deficiency results in decreased expression of CNR1 mRNA
CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]

PMID:9351646 PMID:21955143 PMID:22258905 PMID:27126842

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

catechol-O-methyltransferase

affects response to substance
multiple interactions

COMT protein affects the susceptibility to Morphine
[COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine

PMID:18834357 PMID:21127283

NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642

G

coenzyme Q9

decreases expression

Morphine results in decreased expression of COQ9 protein

NCBI chr19:10,166,948...10,179,976
Ensembl chr19:10,166,951...10,179,949

G

carboxypeptidase E

increases expression

Morphine results in increased expression of CPE mRNA

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

cAMP responsive element binding protein 1

decreases expression
decreases phosphorylation
increases phosphorylation
multiple interactions
increases expression

Morphine results in decreased expression of CREB1 mRNA
morphine decreases phosphorylation of Creb1 protein in prefrontal cortex
morphine increases phosphorylation of Creb protein in Cortical cell
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of CREB1 protein]; suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein]
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]
Morphine results in decreased phosphorylation of CREB1 protein

CTD
RGD

PMID:14750654 PMID:15183518 PMID:16598705 PMID:23292329 PMID:25643298 More...

RGD:401901600, RGD:401901284

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element modulator

increases expression

Morphine results in increased expression of CREM mRNA

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

corticotropin releasing hormone

increases expression

Morphine deficiency results in increased expression of CRH mRNA; Morphine results in increased expression of CRH mRNA

PMID:21955143 PMID:27126842

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

corticotropin releasing hormone receptor 1

multiple interactions

[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]

PMID:24398105 PMID:25582704

NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481

G

C-reactive protein

increases expression

Morphine results in increased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

crystallin, alpha B

decreases expression
increases expression

Morphine results in decreased expression of CRYAB mRNA
Morphine results in increased expression of CRYAB protein

PMID:21955143 PMID:23056601

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

cold shock domain containing C2

decreases expression

Morphine results in decreased expression of CSDC2 mRNA

NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:113,451,998...113,466,463

G

cystatin B

decreases expression

Morphine results in decreased expression of CSTB protein

NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,462...10,247,526

G

catenin alpha-like 1

increases expression

Morphine results in increased expression of CTNNAL1 mRNA

NCBI chr 5:71,514,340...71,569,431
Ensembl chr 5:71,514,340...71,569,431

G

cathepsin B

increases expression

Morphine results in increased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cut-like homeobox 2

increases expression

Morphine results in increased expression of CUX2 mRNA

NCBI chr12:34,507,723...34,707,581
Ensembl chr12:34,520,959...34,705,806

G

C-X3-C motif chemokine ligand 1

affects response to substance
increases secretion

CX3CL1 protein affects the susceptibility to Morphine
Morphine results in increased secretion of CX3CL1 protein

PMID:15317861 PMID:20178837

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 1

increases secretion

Morphine results in increased secretion of CXCL1 protein

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

CXXC finger protein 1

affects expression

Morphine affects the expression of CXXC1 mRNA

NCBI chr18:67,813,185...67,818,556
Ensembl chr18:67,813,206...67,818,551

G

cytochrome b-245 beta chain

increases expression
multiple interactions

Morphine results in increased expression of CYBB protein
Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]

NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586

G

cytochrome c, somatic

increases secretion
decreases secretion
multiple interactions

Morphine results in increased secretion of CYCS protein
Morphine results in decreased secretion of CYCS protein
Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein]

PMID:15345483 PMID:17542780 PMID:19292871

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

Morphine results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 27, subfamily a, polypeptide 1

increases expression

Morphine results in increased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases activity

Morphine results in increased activity of CYP2B6 protein

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, family 2, subfamily d, polypeptide 4

affects chemical synthesis
increases activity
multiple interactions

CYP2D6 protein affects the chemical synthesis of Morphine
Morphine results in increased activity of CYP2D6 protein
[CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine

PMID:15625333 PMID:16595712 PMID:21241245 PMID:35914676

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

dicarbonyl and L-xylulose reductase

multiple interactions
decreases expression

Morphine deficiency affects the reaction [Morphine results in decreased expression of DCXR protein]

NCBI chr10:106,006,404...106,008,293

G

DDAH family member 2, ADMA-independent

multiple interactions
increases expression

Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]

NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511

G

damage specific DNA binding protein 2

increases expression
multiple interactions

Morphine results in increased expression of DDB2 mRNA
Naloxone inhibits the reaction [Morphine results in increased expression of DDB2]

NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

24-dehydrocholesterol reductase

decreases expression

Morphine results in decreased expression of DHCR24 mRNA

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dehydrogenase/reductase 7B

increases expression

Morphine results in increased expression of DHRS7B mRNA

NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076

G

discs large MAGUK scaffold protein 4

decreases expression
multiple interactions
increases expression

Morphine results in decreased expression of DLG4 mRNA; Morphine results in decreased expression of DLG4 protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]
Morphine results in increased expression of DLG4 mRNA

PMID:15183518 PMID:16598705 PMID:21955143 PMID:22713680

NCBI chr10:54,740,700...54,769,097
Ensembl chr10:54,739,470...54,767,153

G

distal-less homeobox 5

increases expression

Morphine results in increased expression of DLX5 mRNA

NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:34,999,139...35,003,407

G

dynein, axonemal, heavy chain 3

decreases expression

Morphine results in decreased expression of DNAH3 mRNA

NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:174,306,644...174,479,474

G

DNA methyltransferase 1

increases expression

Morphine results in increased expression of DNMT1 mRNA

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

DNA methyltransferase 3 alpha

affects expression

Morphine affects the expression of DNMT3A mRNA

NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687

G

DNA methyltransferase 3 beta

affects expression

Morphine affects the expression of DNMT3B mRNA

NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124

G

dedicator of cytokinesis 10

increases expression

Morphine results in increased expression of DOCK10 mRNA

NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:81,843,604...82,101,525

G

dihydropyrimidinase-like 2

multiple interactions
decreases expression

Morphine deficiency affects the reaction [Morphine results in decreased expression of DPYSL2 protein]

NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829

G

dihydropyrimidinase-like 3

multiple interactions
decreases expression

Morphine deficiency promotes the reaction [Morphine results in decreased expression of DPYSL3 protein]

NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157

G

dopamine receptor D1

increases expression
decreases expression

Morphine results in increased expression of DRD1 mRNA
Morphine deficiency results in decreased expression of DRD1 mRNA

PMID:21955143 PMID:27126842

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

decreases expression
multiple interactions
affects response to substance
increases expression

Morphine results in decreased expression of DRD2 mRNA
Morphine deficiency results in decreased expression of DRD2 mRNA
[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA; [lead acetate co-treated with Morphine] results in increased expression of DRD2 protein
DRD2 protein affects the susceptibility to Morphine
Morphine results in increased expression of DRD2 mRNA

PMID:2571179 PMID:15183518 PMID:17063042 PMID:23702354 PMID:27126842

NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875

G

dopamine receptor D4

increases expression

Morphine results in increased expression of DRD4 mRNA

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

G

DS cell adhesion molecule-like 1

increases expression

Morphine results in increased expression of DSCAML1 mRNA

NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320

G

dual specificity phosphatase 6

increases expression

Morphine deficiency results in increased expression of DUSP6 mRNA; Morphine results in increased expression of DUSP6 mRNA

PMID:21955143 PMID:27126842

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

dynein cytoplasmic 1 heavy chain 1

decreases expression

Morphine results in decreased expression of DYNC1H1 mRNA

NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883

G

enoyl-CoA hydratase 1

decreases expression

Morphine results in decreased expression of ECH1 protein

NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795

G

embryonic ectoderm development

increases expression

Morphine results in increased expression of EED mRNA

NCBI chr 1:143,867,875...143,895,008
Ensembl chr 1:143,867,875...143,894,974

G

EF-hand domain family, member D1

decreases expression

Morphine results in decreased expression of EFHD1 mRNA

NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917

G

early growth response 1

increases expression
increases expression

Morphine deficiency results in increased expression of EGR1 mRNA; Morphine results in increased expression of EGR1 mRNA
Morphine increases expression of Egr1 mRNA in ventral tegmental area and prefrontal cortex

CTD
RGD

PMID:21955143 PMID:27126842 PMID:30550948

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

early growth response 2

increases expression

Morphine results in increased expression of EGR2 mRNA

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

early growth response 3

increases expression

Morphine results in increased expression of EGR3 mRNA

NCBI chr15:45,150,335...45,156,052
Ensembl chr15:45,150,567...45,154,627

G

early growth response 4

multiple interactions
increases expression
affects response to substance

2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA]; [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
EGR4 protein affects the susceptibility to Morphine

NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328

G

EH-domain containing 1

multiple interactions
decreases expression

Morphine deficiency inhibits the reaction [Morphine results in decreased expression of EHD1 protein]

NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212

G

euchromatic histone lysine methyltransferase 1

affects expression

Morphine affects the expression of EHMT1 mRNA

NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007

G

euchromatic histone lysine methyltransferase 2

affects expression

Morphine affects the expression of EHMT2 mRNA

NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases phosphorylation

corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]]

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 5A

increases expression

Morphine results in increased expression of EIF5A mRNA

NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656

G

ETS transcription factor ELK1

affects response to substance
increases activity
multiple interactions

ELK1 protein affects the susceptibility to Morphine
Morphine results in increased activity of ELK1 protein
[Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

G

EMAP like 2

increases expression

Morphine results in increased expression of EML2 protein

NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:78,828,080...78,859,341

G

ectonucleotide pyrophosphatase/phosphodiesterase 3

increases expression

Morphine results in increased expression of ENPP3 protein

NCBI chr 1:20,563,700...20,635,044
Ensembl chr 1:20,563,697...20,635,041

G

epoxide hydrolase 2

increases expression

Morphine results in increased expression of EPHX2 mRNA

NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615

G

endoplasmic reticulum protein 44

increases expression

Morphine results in increased expression of ERP44 mRNA

NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:62,516,551...62,610,761

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

multiple interactions
affects expression

Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]
Morphine affects the expression of EZH2 mRNA

PMID:25643298 PMID:33891991

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

coagulation factor II, thrombin

increases expression
multiple interactions

Morphine results in increased expression of F2 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of F2 protein]

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

coagulation factor VII

increases expression

Morphine results in increased expression of F7 protein

NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610

G

family with sequence similarity 107, member A

increases expression

Morphine results in increased expression of FAM107A mRNA

NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396

G

Fas cell surface death receptor

multiple interactions
increases expression

[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein
Morphine results in increased expression of FAS mRNA

PMID:12702572 PMID:16210602

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions
increases expression

[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of FASL mRNA

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

filamin binding LIM protein 1

increases expression
multiple interactions

Morphine results in increased expression of FBLIM1 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of FBLIM1 protein]

NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757

G

fibrillin 1

decreases expression

Morphine results in decreased expression of FBN1 mRNA

NCBI chr 3:112,554,257...112,750,835
Ensembl chr 3:112,554,925...112,750,889

G

fibrinogen alpha chain

affects secretion

Morphine affects the secretion of FGA protein modified form

NCBI chr 2:168,374,120...168,381,523
Ensembl chr 2:168,374,120...168,381,528

G

fibroblast growth factor 2

decreases secretion
multiple interactions

Morphine results in decreased secretion of FGF2 protein
Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fibroblast growth factor receptor 1

increases expression

Morphine results in increased expression of FGFR1 mRNA

NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350

G

fumarate hydratase

increases expression

Morphine results in increased expression of FH protein

NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266

G

four and a half LIM domains 2

multiple interactions
decreases expression

Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]

NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192

G

fibronectin 1

increases expression

Morphine results in increased expression of FN1 mRNA

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
affects expression
increases expression

[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein; [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Plant Extracts inhibits the reaction [Morphine results in increased expression of FOS protein]
Morphine deficiency affects the expression of FOS protein
Morphine results in increased expression of FOS mRNA; Morphine results in increased expression of FOS protein
Morphine affects the expression of FOS mRNA
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Morphine results in increased expression of FOS protein]; [Morphine co-treated with Cocaine] affects the expression of FOS; [Morphine co-treated with N-Methyl-3,4-methylenedioxyamphetamine] affects the expression of FOS; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; Genistein inhibits the reaction [Morphine results in increased expression of FOS protein]; Morphine affects the reaction [Formaldehyde results in increased expression of FOS protein]; N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide inhibits the reaction [Morphine results in increased expression of FOS protein]; Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; U 0126 inhibits the reaction [Morphine results in increased expression of FOS protein]

PMID:10521585 PMID:10814832 PMID:12821175 PMID:12934646 PMID:15183518 More...

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]
morphine increases expression of Fosb protein in nucleus accumbens and caudate-putamen
morphine increases expression of FosB mRNA in striatum
morphine increases expression of Fosb protein in the Brainstem
morphine increases expression of Fosb protein in brain
Morphine results in increased expression of FOSB mRNA
Morphine results in increased expression of FOSB mRNA; Morphine results in increased expression of FOSB protein; Morphine results in increased expression of FOSB protein alternative form; Morphine results in increased expression of FOSB protein modified form

CTD
RGD

PMID:15899480 PMID:18293355 PMID:22454534 PMID:23185589 PMID:19324071 More...

RGD:401901600, RGD:401901284, RGD:401851072, RGD:401900159, RGD:401851068

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

forkhead box P1

increases expression
decreases expression

Morphine results in increased expression of FOXP1 mRNA
Morphine deficiency results in decreased expression of FOXP1 mRNA

PMID:21955143 PMID:27126842

NCBI chr 4:131,559,599...132,155,092
Ensembl chr 4:131,564,756...132,112,258

G

FXYD domain-containing ion transport regulator 7

decreases expression

Morphine results in decreased expression of FXYD7 mRNA

NCBI chr 1:86,277,678...86,286,954
Ensembl chr 1:86,277,678...86,286,954

G

gamma-aminobutyric acid type A receptor subunit alpha 1

decreases expression
increases expression

Morphine results in decreased expression of GABRA1 mRNA
Morphine results in increased expression of GABRA1 mRNA

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit alpha 4

increases expression

Morphine results in increased expression of GABRA4 mRNA

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit delta

increases expression

Morphine results in increased expression of GABRD mRNA

NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411

G

gamma-aminobutyric acid type A receptor subunit gamma 2

increases expression

Morphine results in increased expression of GABRG2 mRNA

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

glutamate decarboxylase 1

increases expression

Morphine results in increased expression of GAD1 mRNA

PMID:15673448 PMID:18312583

NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333

G

glutamate decarboxylase 2

increases expression

Morphine results in increased expression of GAD2 mRNA

NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155

G

galanin and GMAP prepropeptide

increases expression
decreases expression

Morphine results in increased expression of GAL mRNA
Morphine results in decreased expression of GAL mRNA

PMID:21178816 PMID:21955143

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

Morphine results in decreased expression of GAPDH protein

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glucosaminyl (N-acetyl) transferase 2

increases expression
decreases expression

Morphine results in increased expression of GCNT2 mRNA
Morphine deficiency results in decreased expression of GCNT2 mRNA

PMID:21955143 PMID:27126842

NCBI chr17:23,796,859...23,901,625
Ensembl chr17:23,796,859...23,901,611

G

glial fibrillary acidic protein

decreases expression
multiple interactions

Morphine results in decreased expression of GFAP mRNA
[lead acetate co-treated with Morphine] results in increased expression of GFAP mRNA

PMID:21955143 PMID:26478469

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

G elongation factor, mitochondrial 1

decreases expression

Morphine results in decreased expression of GFM1 protein

NCBI chr 2:151,700,573...151,745,477
Ensembl chr 2:151,700,564...151,745,471

G

growth hormone 1

decreases expression
increases secretion

Morphine results in decreased expression of GH mRNA
Morphine results in increased secretion of GH1 protein

PMID:7201058 PMID:21178816

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

gap junction protein, gamma 2

decreases expression

Morphine results in decreased expression of GJC2 mRNA

NCBI chr10:43,962,642...43,971,358
Ensembl chr10:43,962,642...43,970,467

G

glycine receptor, alpha 2

increases expression

Morphine results in increased expression of GLRA2 mRNA

NCBI chr X:29,020,377...29,241,666
Ensembl chr X:29,020,557...29,241,666

G

G protein subunit alpha i2

decreases expression
multiple interactions
increases expression

Morphine results in decreased expression of GNAI2 mRNA
Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]
Morphine results in increased expression of GNAI2 mRNA

PMID:15183518 PMID:18652891

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

GNAS complex locus

increases expression

Morphine results in increased expression of GNAS mRNA; Morphine results in increased expression of GNAS protein

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit alpha z

multiple interactions

Morphine promotes the reaction [GNAZ protein binds to RGS17 protein]

NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907

G

G protein subunit gamma 11

decreases expression

Morphine results in decreased expression of GNG11 mRNA

NCBI chr 4:32,023,003...32,028,443
Ensembl chr 4:32,023,003...32,028,442

G

G protein subunit gamma 2

increases expression

Morphine results in increased expression of GNG2 mRNA

NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,316,059...4,417,183

G

G protein-coupled receptor 6

decreases expression

Morphine results in decreased expression of GPR6 mRNA

NCBI chr20:44,489,853...44,492,624
Ensembl chr20:44,489,853...44,492,624

G

G-protein coupled receptor 88

increases expression
decreases expression

Morphine results in increased expression of GPR88 mRNA
Morphine deficiency results in decreased expression of GPR88 mRNA

PMID:21955143 PMID:27126842

NCBI chr 2:204,191,443...204,199,576
Ensembl chr 2:204,191,427...204,199,733

G

G protein-coupled receptor, class C, group 5, member B

decreases expression

Morphine results in decreased expression of GPRC5B mRNA

NCBI chr 1:173,316,904...173,340,933
Ensembl chr 1:173,316,907...173,340,932

G

glutamate ionotropic receptor AMPA type subunit 1

affects response to substance
increases localization
increases expression
decreases phosphorylation
affects expression
increases phosphorylation
multiple interactions
decreases expression

GRIA1 protein affects the susceptibility to Morphine
Morphine increases localization of Gria1 protein on shell of nucleus accumbens cell surface
Morphine increases expression of Gria protein in the nucleus accumbens
Morphine increases localization of Gria1 protein on nucleus accumbens cell surface
Morphine decreases phosphorylation of Gria1 protein in the caudate-putamen, nucleus accumbens
Morphine alters expression of Gria1 protein in prefrontal cortex membrane
Morphine withdrawal increases phosphorylation of Gria1 protein in hippocampal formation postsynaptic density
Morphine increases expression of Gria1 protein in the striatum
Morphine increases expression of Gria1 protein in the central amygdaloid nucleus
Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]
Morphine results in increased expression of GRIA1 mRNA
Morphine results in decreased expression of GRIA1 mRNA; Morphine results in decreased expression of GRIA1 protein
Morphine results in decreased phosphorylation of GRIA1 protein

CTD
RGD

PMID:11404432 PMID:15183518 PMID:15287884 PMID:23711322 PMID:25643298 More...

RGD:11087075, RGD:405818276, RGD:405650668, RGD:405650198, RGD:405649863, RGD:405101691, RGD:405100728, RGD:405100238

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor AMPA type subunit 2

decreases expression

Morphine results in decreased expression of GRIA2 protein

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

glutamate ionotropic receptor AMPA type subunit 3

decreases expression

Morphine results in decreased expression of GRIA3 mRNA

NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096

G

glutamate ionotropic receptor AMPA type subunit 4

decreases expression

Morphine results in decreased expression of GRIA4 mRNA

NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:1,562,119...2,034,979

G

glutamate ionotropic receptor kainate type subunit 1

multiple interactions
affects response to substance

GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
GRIK1 protein affects the susceptibility to Morphine

NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions
increases expression
increases phosphorylation
decreases phosphorylation
affects phosphorylation

[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]
morphine increases expression of Nr1 protein in cortical neurons
morphine increases phosphorylation of Nr1 protein in frontal cortex and cortical neurons
Morphine results in increased expression of GRIN1 protein
Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]; Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein]
Morphine results in decreased phosphorylation of GRIN1 protein
Morphine affects the phosphorylation of GRIN1 protein

CTD
RGD

PMID:15287884 PMID:17996026 PMID:20519536 PMID:20950603 PMID:22713680 More...

RGD:401901284, RGD:401901284

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

increases expression
affects response to substance

Morphine results in increased expression of GRIN2A protein
GRIN2A protein affects the susceptibility to Morphine

PMID:12878694 PMID:33609567

NCBI chr10:5,629,683...6,053,262
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions
increases expression
increases phosphorylation

MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]
Morphine results in increased expression of GRIN2B protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein]

PMID:20519536 PMID:22713680

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glutamate ionotropic receptor NMDA type subunit 2C

increases expression

Morphine results in increased expression of GRIN2C mRNA

NCBI chr10:100,488,430...100,507,083
Ensembl chr10:100,488,431...100,506,427

G

G protein-coupled receptor kinase 5

increases expression

Morphine results in increased expression of GRK5 mRNA

NCBI chr 1:260,028,269...260,223,699
Ensembl chr 1:260,028,242...260,218,701

G

glutamate metabotropic receptor 1

increases expression

Morphine results in increased expression of GRM1 mRNA

NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170

G

glutamate metabotropic receptor 5

increases expression
decreases expression

Morphine results in increased expression of GRM5 mRNA
Morphine deficiency results in decreased expression of GRM5 mRNA

PMID:21955143 PMID:27126842

NCBI chr 1:141,310,069...141,884,980
Ensembl chr 1:141,312,368...141,882,274

G

glycogen synthase kinase 3 beta

increases expression
multiple interactions

Morphine results in increased expression of GSK3B protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

hypocretin receptor 1

increases expression

Morphine results in increased expression of HCRTR1 mRNA; Morphine results in increased expression of HCRTR1 protein

NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:142,477,214...142,486,674

G

histone deacetylase 5

increases expression

Morphine results in increased expression of HDAC5 protein

NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235

G

histidine triad nucleotide binding protein 1

multiple interactions
increases response to substance

HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
HINT1 gene mutant form results in increased susceptibility to Morphine

PMID:18652891 PMID:21235400

NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568

G

3-hydroxy-3-methylglutaryl-CoA synthase 1

decreases expression

Morphine results in decreased expression of HMGCS1 mRNA

NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

increases expression

Morphine results in increased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heme oxygenase 1

increases expression

Morphine results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heme oxygenase 2

decreases activity
increases activity

Morphine results in decreased activity of HMOX2 protein
Morphine results in increased activity of HMOX2 protein

NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148

G

heterogeneous nuclear ribonucleoprotein D-like

increases expression

Morphine results in increased expression of HNRNPDL mRNA

NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506

G

heterogeneous nuclear ribonucleoprotein L

increases expression

Morphine deficiency results in increased expression of HNRNPL mRNA; Morphine results in increased expression of HNRNPL mRNA

PMID:21955143 PMID:27126842

NCBI chr 1:84,098,558...84,111,568
Ensembl chr 1:84,100,879...84,111,553

G

homer scaffold protein 1

increases expression

Morphine results in increased expression of HOMER1 mRNA

NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785

G

haptoglobin

decreases expression

Morphine results in decreased expression of HP protein

NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523

G

hippocalcin

increases expression
decreases expression

Morphine results in increased expression of HPCA mRNA
Morphine deficiency results in decreased expression of HPCA mRNA

PMID:21955143 PMID:27126842

NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841

G

histamine receptor H 1

multiple interactions
decreases response to substance

Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]

PMID:12128009 PMID:14569158

NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455

G

histamine receptor H 2

multiple interactions
decreases response to substance

[zolantidine binds to and results in decreased activity of HRH2 protein] which results in increased susceptibility to Morphine; Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]
HRH2 protein results in decreased susceptibility to Morphine; HRH2 results in decreased susceptibility to Morphine

PMID:14569158 PMID:16806305

NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631

G

heparan sulfate 6-O-sulfotransferase 2

increases expression

Morphine results in increased expression of HS6ST2 mRNA

NCBI chr X:130,966,547...131,261,629
Ensembl chr X:130,968,385...131,261,492

G

hydroxysteroid 11-beta dehydrogenase 1

decreases expression

Morphine results in decreased expression of HSD11B1 mRNA

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

heat shock protein 90 alpha family class B member 1

increases expression

Morphine results in increased expression of HSP90AB1 mRNA

NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein 90 beta family member 1

decreases expression

Morphine results in decreased expression of HSP90B1 protein

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA]
Morphine results in increased expression of HSPA1A mRNA; Morphine results in increased expression of HSPA1A protein

PMID:15497504 PMID:23056601

NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Morphine results in increased expression of HSPA5 protein
corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family A (Hsp70) member 8

increases expression

Morphine results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family B (small) member 1

increases expression

Morphine results in increased expression of HSPB1 mRNA; Morphine results in increased expression of HSPB1 protein

PMID:15497504 PMID:23056601

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family E (Hsp10) member 1

increases expression

Morphine results in increased expression of HSPE1 protein

NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089

G

5-hydroxytryptamine receptor 1A

multiple interactions
decreases expression

4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine
Morphine decreases expression of Htr1a mRNA in the dorsal raphe nucleus

CTD
RGD

PMID:10640309 PMID:24055683

NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442

G

5-hydroxytryptamine receptor 3A

increases expression

Morphine results in increased expression of HTR3A mRNA

NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389

G

intercellular adhesion molecule 1

decreases expression
multiple interactions

Morphine results in decreased expression of ICAM1 protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta

decreases expression
multiple interactions

Morphine results in decreased expression of IDH3B protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of IDH3B protein]

NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:117,481,845...117,486,982

G

interferon gamma

decreases expression
multiple interactions

Morphine results in decreased expression of IFNG
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

immunoglobulin superfamily, member 1

decreases expression

Morphine results in decreased expression of IGSF1 mRNA

NCBI chr X:129,069,891...129,085,331
Ensembl chr X:129,069,896...129,085,139

G

interleukin 12A

multiple interactions

Morphine affects the expression of [IL12A protein binds to IL12B protein]

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

multiple interactions
affects expression

Morphine affects the expression of [IL12A protein binds to IL12B protein]
Morphine affects the expression of IL12B protein

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 13

increases expression

Morphine results in increased expression of IL13 protein

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 alpha

multiple interactions
decreases expression

Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]; Dexamethasone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Dexamethasone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]; Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases expression
increases secretion

Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA]
corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]
Morphine results in increased expression of IL1B mRNA; Morphine results in increased expression of IL1B protein
Morphine results in increased secretion of IL1B protein

PMID:12427855 PMID:20178837 PMID:21081778 PMID:22713680 PMID:24756886 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

affects response to substance

IL1RN protein affects the susceptibility to Morphine

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2

decreases expression
multiple interactions

Morphine results in decreased expression of IL2
Morphine results in decreased expression of IL2 mRNA
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]

PMID:11590188 PMID:23965172

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

multiple interactions
increases expression

[FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of IL4 mRNA; Morphine results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Morphine results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Morphine results in increased expression of IL4 mRNA]

PMID:16210602 PMID:23965172

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases secretion
multiple interactions
increases expression

Morphine results in increased secretion of IL6 protein
corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]
Morphine results in increased expression of IL6 mRNA; Morphine results in increased expression of IL6 protein
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL6 mRNA]

PMID:12427855 PMID:15317861 PMID:20564181 PMID:21081778 PMID:22713680 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibitor of growth family, member 2

multiple interactions

Morphine promotes the reaction [ING2 protein binds to BDNF promoter]

NCBI chr16:44,573,592...44,584,180
Ensembl chr16:44,575,597...44,583,482

G

integrin subunit alpha M

increases expression

Morphine results in increased expression of ITGAM mRNA

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Morphine results in increased phosphorylation of and results in increased activity of JUN protein; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

JunB proto-oncogene, AP-1 transcription factor subunit

increases expression

Morphine results in increased expression of JUNB mRNA

NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035

G

KLF transcription factor 7

increases expression
multiple interactions

Morphine results in increased expression of KLF7 mRNA; Morphine results in increased expression of KLF7 protein
Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA]

NCBI chr 9:65,433,683...65,526,372
Ensembl chr 9:65,437,167...65,526,261

G

killer cell lectin like receptor K1

decreases expression

Morphine results in decreased expression of KLRK1 mRNA

NCBI chr 4:163,079,887...163,092,434
Ensembl chr 4:163,081,927...163,092,459

G

lysine methyltransferase 2A

multiple interactions
affects expression

Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]
Morphine affects the expression of KMT2A mRNA

PMID:25643298 PMID:33891991

NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181

G

keratin 1

decreases expression

Morphine results in decreased expression of KRT1 protein

NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844

G

keratin 10

multiple interactions
decreases expression

Morphine deficiency inhibits the reaction [Morphine results in decreased expression of KRT10 protein]

NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701

G

keratin 2

decreases expression
multiple interactions

Morphine results in decreased expression of KRT2 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT2 protein]

NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:132,940,862...132,947,963

G

keratin 33A

multiple interactions
increases expression

Morphine deficiency inhibits the reaction [Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]]; Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]

NCBI chr10:84,942,584...84,947,544
Ensembl chr10:84,942,573...84,947,478

G

keratin 5

decreases expression

Morphine results in decreased expression of KRT5 protein

NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850

G

keratin 8

multiple interactions
decreases expression

Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]]; Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]

NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728

G

lipocalin 2

increases expression

Morphine results in increased expression of LCN2 mRNA

NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095

G

leptin receptor

increases expression

Morphine results in increased expression of LEPR mRNA

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

luteinizing hormone subunit beta

decreases expression

Morphine results in decreased expression of LHB protein

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

lin-7 homolog C, crumbs cell polarity complex component

decreases expression

Morphine results in decreased expression of LIN7C mRNA

NCBI chr 3:96,406,800...96,417,779
Ensembl chr 3:96,406,813...96,417,728

G

lipopolysaccharide-induced TNF factor

decreases expression

Morphine results in decreased expression of LITAF mRNA

NCBI chr10:4,656,308...4,692,981
Ensembl chr10:4,625,552...4,692,763

G

LIM domain 7

increases expression

Morphine results in increased expression of LMO7 mRNA

NCBI chr15:78,566,999...78,769,833
Ensembl chr15:78,567,023...78,769,783

G

LIM homeobox transcription factor 1 beta

increases expression

Morphine results in increased expression of LMX1B mRNA

NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:16,862,195...16,940,899

G

lipoprotein lipase

increases expression

Morphine results in increased expression of LPL mRNA

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

LDL receptor related protein 1

decreases expression

Morphine results in decreased expression of LRP1 mRNA

NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910

G

leucine-rich pentatricopeptide repeat containing

increases expression

Morphine results in increased expression of LRPPRC mRNA

NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293

G

microtubule-associated protein 2

decreases expression

Morphine results in decreased expression of MAP2 mRNA

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

increases expression
increases phosphorylation
multiple interactions

Morphine results in increased expression of MAPK1 protein modified form
Morphine results in increased phosphorylation of MAPK1 protein
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
Morphine deficiency results in increased phosphorylation of MAPK1 protein; Morphine results in increased phosphorylation of MAPK1 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]

PMID:15196791 PMID:20359526 PMID:20519536 PMID:21235400 PMID:21483469 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

increases expression

Morphine results in increased expression of MAPK14 protein

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine deficiency results in increased phosphorylation of MAPK3 protein; Morphine results in increased phosphorylation of MAPK3 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]

PMID:20519536 PMID:21235400 PMID:21483469 PMID:21600884 PMID:23965172 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

increases expression

Morphine results in increased expression of MAPT mRNA

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

myristoylated alanine rich protein kinase C substrate

decreases expression

Morphine results in decreased expression of MARCKS protein

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

mitochondrial antiviral signaling protein

increases expression

Morphine results in increased expression of MAVS protein

NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094

G

methyl-CpG binding domain protein 1

affects expression

Morphine affects the expression of MBD1 mRNA

NCBI chr18:67,869,870...67,884,501
Ensembl chr18:67,869,992...67,886,554

G

methyl-CpG binding domain protein 3

decreases expression

Morphine results in decreased expression of MBD3 mRNA

NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165

G

methyl-CpG binding domain 4 DNA glycosylase

affects expression

Morphine affects the expression of MBD4 mRNA

NCBI chr 4:148,893,049...148,904,833
Ensembl chr 4:148,894,280...148,904,982

G

MCL1 apoptosis regulator, BCL2 family member

increases expression

Morphine results in increased expression of MCL1 mRNA

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

multiple C2 and transmembrane domain containing 1

increases expression

Morphine results in increased expression of MCTP1 mRNA

NCBI chr 2:6,071,408...6,761,833
Ensembl chr 2:6,065,808...6,761,833

G

malic enzyme 3

increases expression

Morphine results in increased expression of ME3 mRNA

NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:143,534,139...143,733,132

G

microRNA 107

decreases expression

Morphine results in decreased expression of MIR107

NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853

G

microRNA 132

increases expression

Morphine results in increased expression of MIR132

NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796

G

microRNA 146a

increases expression

Morphine results in increased expression of MIR146A

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

microRNA 150

increases expression

Morphine results in increased expression of MIR150

NCBI chr 1:95,605,024...95,605,108
Ensembl chr 1:95,605,024...95,605,108

G

microRNA 155

increases expression

Morphine results in increased expression of MIR155

NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718

G

microRNA 15b

increases expression

Morphine results in increased expression of MIR15B

NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297

G

microRNA 191

decreases expression

Morphine results in decreased expression of MIR191

NCBI chr 8:109,264,098...109,264,188

G

microRNA 21

decreases expression

Morphine results in decreased expression of MIR21

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

microRNA 221

increases expression

Morphine results in increased expression of MIR221

NCBI chr X:3,429,465...3,429,573
Ensembl chr X:3,429,465...3,429,573

G

microRNA 23a

increases expression

Morphine results in increased expression of MIR23A

NCBI chr19:23,954,997...23,955,071
Ensembl chr19:23,954,997...23,955,071

G

microRNA 23b

increases expression

Morphine results in increased expression of MIR23B

NCBI chr17:1,813,667...1,813,763
Ensembl chr17:1,813,667...1,813,763

G

microRNA 26a

decreases expression

Morphine results in decreased expression of MIR26A1

NCBI chr 8:118,755,289...118,755,378
Ensembl chr 8:118,755,289...118,755,378

G

microRNA 26b

decreases expression

Morphine results in decreased expression of MIR26B

NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680

G

microRNA 320a

decreases expression

Morphine results in decreased expression of MIR320A

NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473

G

microRNA 423

decreases expression

Morphine results in decreased expression of MIR423

NCBI chr10:61,914,142...61,914,220
Ensembl chr10:61,914,133...61,914,226

G

microRNA 99b

decreases expression

Morphine results in decreased expression of MIR99B

NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090

G

membrane metallo-endopeptidase

multiple interactions
increases activity

Naloxone inhibits the reaction [Morphine results in increased activity of MME protein]; phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein]

NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792

G

matrix metallopeptidase 9

multiple interactions
increases activity

[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine results in increased activity of MMP9 protein

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

macrophage expressed 1

increases expression

Morphine results in increased expression of MPEG1 mRNA

NCBI chr 1:209,452,176...209,456,692
Ensembl chr 1:209,452,133...209,458,855

G

myosin XIX

decreases expression

Morphine results in decreased expression of MYO19 mRNA

NCBI chr10:69,753,082...69,782,450
Ensembl chr10:69,753,068...69,782,450

G

NLR family, apoptosis inhibitory protein 6

increases expression

Morphine results in increased expression of NAIP mRNA

NCBI chr 2:31,507,423...31,559,098
Ensembl chr 2:31,507,424...31,570,542

G

neuron navigator 1

decreases expression

Morphine results in decreased expression of NAV1 mRNA

NCBI chr13:46,866,972...47,119,368
Ensembl chr13:46,873,689...47,126,449

G

neural cell adhesion molecule 1

decreases expression

Morphine results in decreased expression of NCAM1 protein modified form

NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014

G

NADH:ubiquinone oxidoreductase subunit AB1

affects expression

Morphine affects the expression of NDUFAB1 mRNA

NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099

G

NADH:ubiquinone oxidoreductase core subunit V2

increases expression

Morphine results in increased expression of NDUFV2 protein

NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713

G

neurofilament heavy chain

increases expression

Morphine results in increased expression of NEFH mRNA

NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351

G

nestin

decreases expression

Morphine results in decreased expression of NES mRNA

NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777

G

nuclear factor kappa B subunit 1

increases expression

Morphine results in increased expression of NFKB1 mRNA

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

increases phosphorylation
affects response to substance
increases expression
increases degradation
multiple interactions

Morphine results in increased phosphorylation of NFKBIA protein
NFKBIA protein affects the susceptibility to Morphine
Morphine results in increased expression of NFKBIA protein
Morphine results in increased degradation of NFKBIA protein
Morphine results in increased expression of NFKBIA mRNA; Morphine results in increased expression of NFKBIA protein
Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Cycloheximide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Morphine inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]

PMID:17542780 PMID:19070643 PMID:22258905 PMID:24068670

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

ninjurin 1

increases expression

Morphine results in increased expression of NINJ1 mRNA

NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704

G

NLR family, pyrin domain containing 3

multiple interactions
increases expression

corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 1

multiple interactions
decreases expression
increases expression

[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]
Morphine results in decreased expression of NOS1 protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]

PMID:16598705 PMID:20519536 PMID:20568289

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

increases expression
multiple interactions
affects response to substance

Morphine results in increased expression of NOS2 mRNA; Morphine results in increased expression of NOS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]
NOS2 protein affects the susceptibility to Morphine

PMID:11590188 PMID:15220775 PMID:16325209 PMID:19751225 PMID:24756886 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuropeptide Y

increases expression

Morphine results in increased expression of NPY mRNA

PMID:20144693 PMID:21178816

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

neuropeptide Y receptor Y1

decreases expression

Morphine results in decreased expression of NPY1R mRNA

NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

[Mifepristone binds to and results in decreased activity of NR3C1 protein] which results in decreased susceptibility to Morphine

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

nuclear receptor subfamily 4, group A, member 1

increases expression

Morphine results in increased expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 2

multiple interactions
decreases expression
affects response to substance

BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]
Morphine results in decreased expression of NR4A2 mRNA
Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

G

neuronal cell adhesion molecule

increases expression

Morphine results in increased expression of NRCAM mRNA; Morphine results in increased expression of NRCAM mRNA alternative form

NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992

G

neuritin 1

decreases expression

Morphine results in decreased expression of NRN1 mRNA

NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,129,977...28,138,896

G

neurexin 3

increases expression

Morphine results in increased expression of NRXN3 mRNA

NCBI chr 6:107,641,760...109,272,849
Ensembl chr 6:107,641,780...109,272,044

G

netrin G1

decreases expression

Morphine results in decreased expression of NTNG1 mRNA

NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:197,463,945...197,826,997

G

neurotensin receptor 1

affects response to substance

NTSR1 protein affects the susceptibility to Morphine

NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:167,606,215...167,656,377

G

oligodendrocytic myelin paranodal and inner loop protein

decreases expression

Morphine results in decreased expression of OPALIN mRNA

NCBI chr 1:239,891,137...239,909,388
Ensembl chr 1:239,891,142...239,908,788

G

opioid receptor, delta 1

multiple interactions
increases expression
affects binding

ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine binds to OPRD1 protein

PMID:7562497 PMID:21600884 PMID:35477798

NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:144,306,188...144,340,960

G

opioid receptor, kappa 1

affects activity
increases activity
increases expression
affects binding
multiple interactions

Morphine affects the activity of OPRK1 protein
Morphine results in increased activity of OPRK1 protein
Morphine results in increased expression of OPRK1 mRNA
Morphine binds to OPRK1 protein
Morphine inhibits the reaction [Zymosan results in decreased expression of OPRK1 mRNA]

PMID:7562497 PMID:15979727 PMID:18385270 PMID:22661197 PMID:26476280 More...

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

opioid related nociceptin receptor 1

multiple interactions

[J 113397 binds to and results in decreased activity of OPRL1 protein] which affects the susceptibility to Morphine

NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:168,834,003...168,839,920

G

opioid receptor, mu 1

multiple interactions
increases phosphorylation
increases activity
decreases expression
affects response to substance
increases expression
affects binding
affects activity
decreases response to substance

[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
Morphine results in increased phosphorylation of OPRM1 protein
Morphine results in increased activity of OPRM1 protein
Morphine results in decreased expression of OPRM1 mRNA
OPRM1 affects the susceptibility to Morphine; OPRM1 protein affects the susceptibility to Morphine
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; [phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNA; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; valyl-prolyl-aspartyl-prolyl-arginine inhibits the reaction [Morphine results in increased activity of OPRM1 protein]
Morphine results in increased expression of OPRM1 protein
Morphine binds to OPRM1 protein
OPRM1 affects the activity of Morphine
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which affects the susceptibility to Morphine; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein
OPRM1 exon SNP results in decreased susceptibility to Morphine
Morphine affects the activity of OPRM1 protein

PMID:7562497 PMID:8884884 PMID:9264103 PMID:10803207 PMID:11106302 More...

NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409

G

3-oxoacid CoA transferase 1

decreases expression

Morphine results in decreased expression of OXCT1 protein

NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:53,236,368...53,384,714

G

PATJ, crumbs cell polarity complex component

decreases expression

Morphine results in decreased expression of PATJ mRNA

NCBI chr 5:113,061,985...113,364,807
Ensembl chr 5:113,062,118...113,364,807

G

proprotein convertase subtilisin/kexin type 1 inhibitor

increases expression

Morphine results in increased expression of PCSK1N mRNA

NCBI chr X:14,580,036...14,583,478
Ensembl chr X:14,580,038...14,583,566

G

programmed cell death 5

increases expression

Morphine results in increased expression of PDCD5 protein

NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:88,305,869...88,311,200

G

phosphodiesterase 10A

decreases expression

Morphine deficiency results in decreased expression of PDE10A mRNA; Morphine results in decreased expression of PDE10A mRNA

PMID:21955143 PMID:27126842

NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563

G

platelet derived growth factor subunit B

multiple interactions
decreases response to substance

PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
PDGFB protein results in decreased susceptibility to Morphine

NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984

G

pyruvate dehydrogenase E1 subunit beta

increases expression
multiple interactions

Morphine results in increased expression of PDHB protein
Morphine deficiency affects the reaction [Morphine results in increased expression of PDHB protein]

NCBI chr15:16,752,561...16,758,503
Ensembl chr15:16,750,980...16,758,500

G

pyruvate dehydrogenase kinase 1

decreases expression

Morphine results in decreased expression of PDK1 protein

NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038

G

pyruvate dehydrogenase kinase 2

decreases expression

Morphine results in decreased expression of PDK2 protein

NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085

G

PDZ and LIM domain 2

decreases expression

Morphine results in decreased expression of PDLIM2 mRNA

NCBI chr15:45,235,421...45,250,187
Ensembl chr15:45,237,477...45,249,242

G

prodynorphin

increases expression
decreases expression
multiple interactions

Morphine results in increased expression of PDYN protein alternative form
Morphine deficiency results in decreased expression of PDYN mRNA
Morphine results in decreased expression of PDYN mRNA
[Zymosan co-treated with Morphine] results in increased expression of PDYN mRNA; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]

PMID:15979727 PMID:17401159 PMID:20359526 PMID:27126842

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

proenkephalin

multiple interactions
decreases expression

Morphine inhibits the reaction [Formaldehyde results in increased expression of PENK mRNA]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein]
Morphine deficiency results in decreased expression of PENK mRNA

PMID:7978486 PMID:20568289 PMID:27126842

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

period circadian regulator 1

affects expression

Morphine affects the expression of PER1 mRNA

NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431

G

period circadian regulator 2

affects response to substance
affects expression

PER2 protein affects the susceptibility to Morphine
Morphine affects the expression of PER2 mRNA

PMID:19383088 PMID:20434889

NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459

G

PPARGC1 and ESRR induced regulator, muscle 1

multiple interactions
increases expression

Morphine deficiency affects the reaction [Morphine results in increased expression of PERM1 protein]

NCBI chr 5:166,800,030...166,805,323
Ensembl chr 5:166,800,030...166,805,323

G

pleckstrin homology-like domain, family B, member 1

decreases expression

Morphine results in decreased expression of PHLDB1 mRNA

NCBI chr 8:45,003,543...45,051,541
Ensembl chr 8:45,003,538...45,051,522

G

phosphatidylinositol glycan anchor biosynthesis, class A

decreases expression

Morphine results in decreased expression of PIGA mRNA

NCBI chr X:30,043,033...30,055,861
Ensembl chr X:30,042,343...30,055,804

G

PBX/knotted 1 homeobox 1

increases expression

Morphine results in increased expression of PKNOX1 mRNA

NCBI chr20:9,662,866...9,705,030
Ensembl chr20:9,662,899...9,703,727

G

plasminogen activator, tissue type

affects response to substance

PLAT protein affects the susceptibility to Morphine

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

phospholipase C beta 1

affects response to substance

PLCB1 protein affects the susceptibility to Morphine

NCBI chr 3:122,059,988...122,772,896
Ensembl chr 3:122,060,031...122,772,869

G

phospholipase C, delta 1

multiple interactions
increases expression

Morphine deficiency inhibits the reaction [Morphine results in increased expression of PLCD1 protein]

NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186

G

phospholipase C, delta 4

decreases expression

Morphine results in decreased expression of PLCD4 mRNA

NCBI chr 9:76,115,523...76,158,602
Ensembl chr 9:76,117,168...76,142,453

G

pleckstrin homology and RhoGEF domain containing G1

decreases expression

Morphine results in decreased expression of PLEKHG1 mRNA

NCBI chr 1:40,348,684...40,434,063
Ensembl chr 1:40,311,221...40,434,063

G

plasminogen

affects response to substance

PLG protein affects the susceptibility to Morphine

NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786

G

plasmolipin

decreases expression

Morphine results in decreased expression of PLLP mRNA

NCBI chr19:10,315,104...10,335,892
Ensembl chr19:10,315,104...10,335,892

G

prepronociceptin

decreases response to substance

PNOC protein results in decreased susceptibility to Morphine

NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867

G

patatin-like phospholipase domain containing 3

increases expression

Morphine results in increased expression of PNPLA3 mRNA

NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077

G

proopiomelanocortin

multiple interactions
increases secretion
increases expression

[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form
Morphine deficiency results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
[Zymosan co-treated with Morphine] results in increased expression of POMC mRNA
Morphine results in increased expression of POMC mRNA

PMID:2846107 PMID:15979727 PMID:20084599 PMID:20144693 PMID:24398105

NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664

G

peptidylprolyl isomerase A

increases expression

Morphine results in increased expression of PPIA protein

NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601

G

protein phosphatase 1, regulatory (inhibitor) subunit 1B

affects expression
multiple interactions
increases phosphorylation

Morphine affects the expression of PPP1R1B protein modified form
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]

PMID:15287884 PMID:21600884

NCBI chr10:83,347,731...83,356,775
Ensembl chr10:83,347,731...83,356,775

G

protein phosphatase 3, regulatory subunit B, alpha

increases expression

Morphine deficiency results in increased expression of PPP3R1 mRNA; Morphine results in increased expression of PPP3R1 mRNA

PMID:21955143 PMID:27126842

NCBI chr14:91,556,743...91,606,391
Ensembl chr14:91,604,121...91,606,907

G

protein kinase C, alpha

multiple interactions

Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

protein kinase C, beta

multiple interactions

HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

protein kinase C, delta

decreases expression

Morphine results in decreased expression of PRKCD mRNA

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

protein kinase C, gamma

multiple interactions
increases expression

PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein]
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]
Morphine results in increased expression of PRKCG protein modified form

PMID:18652891 PMID:20359526 PMID:20568289 PMID:21235400

NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384

G

protein kinase cGMP-dependent 1

multiple interactions

Morphine inhibits the reaction [Formaldehyde results in increased expression of PRKG1 protein]

NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080

G

prolactin

increases secretion

Morphine results in increased secretion of PRL protein

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

proline rich 18

decreases expression

Morphine results in decreased expression of PRR18 mRNA

NCBI chr 1:52,400,215...52,403,998
Ensembl chr 1:52,400,215...52,404,309

G

proteasome 20S subunit alpha 5

increases expression

Morphine results in increased expression of PSMA5 protein

NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:195,896,365...195,919,731

G

proteasome 26S subunit ubiquitin receptor, non-ATPase 2

multiple interactions
decreases expression

Morphine deficiency inhibits the reaction [Morphine results in decreased expression of PSMD2 protein]

NCBI chr11:80,248,364...80,258,991
Ensembl chr11:80,248,364...80,259,043

G

phosphatidylserine synthase 2

increases expression

Morphine results in increased expression of PTDSS2 mRNA

NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:196,241,494...196,267,685

G

prostaglandin-endoperoxide synthase 1

decreases expression
increases expression
multiple interactions

Morphine results in decreased expression of PTGS1 mRNA
Morphine results in increased expression of PTGS1 mRNA
Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA]

PMID:15183518 PMID:18706994

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

Morphine results in increased expression of PTGS2 protein
[nimesulide results in decreased activity of PTGS2 protein] which results in increased susceptibility to Morphine
[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]

PMID:14511336 PMID:16325209 PMID:37394652

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

decreases phosphorylation

morphine decreases phosphorylation of Ptk2 in rat ventral tegmental area neurons

RGD

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

parvalbumin

decreases expression

Morphine results in decreased expression of PVALB mRNA

NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561

G

PYD and CARD domain containing

decreases expression
increases expression
multiple interactions

Morphine results in decreased expression of PYCARD mRNA
Morphine results in increased expression of PYCARD protein
corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]; Minocycline inhibits the reaction [Morphine results in increased expression of PYCARD protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]

PMID:20144693 PMID:37394652

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

peptide YY

increases expression

Morphine results in increased expression of PYY mRNA

NCBI chr10:87,061,155...87,062,278
Ensembl chr10:87,061,161...87,061,815

G

RAB11B, member RAS oncogene family

increases expression

Morphine results in increased expression of RAB11B mRNA

NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593

G

RAB3A, member RAS oncogene family

affects expression

Morphine affects the expression of RAB3A protein

NCBI chr16:18,684,185...18,688,297
Ensembl chr16:18,684,188...18,688,336

G

Raf-1 proto-oncogene, serine/threonine kinase

affects response to substance
multiple interactions

RAF1 protein affects the susceptibility to Morphine
HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]

PMID:18976650 PMID:21235400

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

receptor activity modifying protein 3

decreases expression

Morphine results in decreased expression of RAMP3 mRNA

NCBI chr14:81,527,404...81,544,905
Ensembl chr14:81,527,385...81,544,902

G

RB binding protein 5, histone lysine methyltransferase complex subunit

decreases expression

Morphine results in decreased expression of RBBP5 mRNA

NCBI chr13:43,912,254...43,939,107
Ensembl chr13:43,912,254...43,939,107

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases phosphorylation

Morphine inhibits the reaction [Doxorubicin affects the localization of RELA protein]
Colforsin inhibits the reaction [Morphine results in increased phosphorylation of RELA protein]

PMID:17542780 PMID:22258905

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

reelin

decreases expression

Morphine results in decreased expression of RELN mRNA

NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211

G

RRAD and GEM like GTPase 2

increases expression

Morphine results in increased expression of REM2 mRNA

NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429

G

regulator of G-protein signaling 17

multiple interactions

Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]; Morphine promotes the reaction [GNAZ protein binds to RGS17 protein]

NCBI chr 1:42,222,248...42,324,625
Ensembl chr 1:42,227,070...42,324,609

G

regulator of G-protein signaling 4

decreases expression
increases expression

Morphine results in decreased expression of RGS4 mRNA
Morphine results in increased expression of RGS4 mRNA

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

G

regulator of G-protein signaling 6

increases expression

Morphine results in increased expression of RGS6 mRNA

NCBI chr 6:102,264,451...102,796,311
Ensembl chr 6:102,264,447...102,824,753

G

ring finger protein 1

multiple interactions

Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]

NCBI chr20:4,830,120...4,833,623
Ensembl chr20:4,830,053...4,833,620

G

rabphilin 3A

decreases expression

Morphine results in decreased expression of RPH3A mRNA

NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592

G

ribonucleotide reductase regulatory TP53 inducible subunit M2B

increases expression

Morphine results in increased expression of RRM2B mRNA

NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633

G

S100 calcium binding protein B

decreases expression

Morphine results in decreased expression of S100B mRNA

NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743

G

syndecan 4

increases expression

Morphine deficiency results in increased expression of SDC4 mRNA; Morphine results in increased expression of SDC4 mRNA

PMID:21955143 PMID:27126842

NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions
increases expression

Morphine deficiency affects the reaction [Morphine results in increased expression of SDHA protein]

NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535

G

selectin L

decreases expression
multiple interactions

Morphine results in decreased expression of SELL protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]

NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456

G

septin 7

multiple interactions
decreases expression

Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein]

NCBI chr 8:23,719,448...23,783,247
Ensembl chr 8:23,716,030...23,783,243

G

septin 8

decreases expression

Morphine results in decreased expression of SEPTIN8 mRNA

NCBI chr10:37,684,649...37,713,704
Ensembl chr10:37,684,639...37,713,174

G

serpin family B member 1A

decreases expression

Morphine results in decreased expression of SERPINB1A mRNA

NCBI chr17:31,590,695...31,599,102
Ensembl chr17:31,590,677...31,599,102

G

serpin family F member 1

decreases expression

Morphine results in decreased expression of SERPINF1 mRNA

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

G

serpin family G member 1

multiple interactions
decreases expression

Morphine deficiency affects the reaction [Morphine results in decreased expression of SERPING1 protein]

NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034

G

SERTA domain containing 4

increases expression

Morphine results in increased expression of SERTAD4 mRNA

NCBI chr13:104,360,307...104,371,064
Ensembl chr13:104,360,307...104,370,546

G

SET domain containing 1A, histone lysine methyltransferase

affects expression