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Pathways

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:opioid agent
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Accession:CHEBI:60598 term browser browse the term
Definition:Any agent that acts on an opioid receptor or affects the life cycle of an opioid transmitter.
Synonyms:related_synonym: opioid agents



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(R,R)-tramadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases expression EXP Tramadol results in increased expression of ADRA1A protein CTD PMID:15464068 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein] CTD PMID:31618080 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Tramadol results in increased expression of BAX protein CTD PMID:25550769 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Tramadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
G Casp3 caspase 3 affects activity
multiple interactions
increases expression
decreases activity
ISO
EXP
Tramadol affects the activity of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein
CTD PMID:27317026 PMID:28499616 PMID:31618080 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
CTD PMID:25550769 PMID:31618080 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ckb creatine kinase B decreases expression
multiple interactions
ISO
EXP
Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
CTD PMID:27317026 PMID:33645892 NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein] CTD PMID:33645892 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Tramadol results in decreased activity of CYP17A1 protein CTD PMID:29100959 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
affects methylation
multiple interactions
decreases methylation
affects response to substance
decreases response to substance
increases response to substance
increases metabolic processing
ISO CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CTD PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More... NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Des desmin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of DES protein] CTD PMID:33645892 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Tramadol results in increased expression of DRD2 protein CTD PMID:15464068 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Tramadol results in increased expression of DRD3 protein CTD PMID:15464068 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein] CTD PMID:33645892 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein] CTD PMID:31618080 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
increases expression
EXP Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]
CTD PMID:28689766 PMID:31618080 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A increases activity
increases expression
multiple interactions
EXP Tramadol results in increased activity of HTR2A protein
Tramadol results in increased expression of HTR2A mRNA
Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
CTD PMID:18417104 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
JBrowse link
G Ifng interferon gamma multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein] CTD PMID:33645892 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Tramadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Tramadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Tramadol binds to OPRK1 protein
[Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding
multiple interactions
EXP Tramadol binds to OPRM1 protein
[Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO Tramadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:58,486,699...58,553,533
Ensembl chr  X:62,480,535...62,547,371
JBrowse link
G Pdyn prodynorphin decreases expression EXP Tramadol results in decreased expression of PDYN mRNA CTD PMID:17401159 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA CTD PMID:31276069 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA CTD PMID:31276069 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:11723065 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
CTD PMID:25550769 PMID:31618080 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA
CTD PMID:25550769 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
EXP Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein] CTD PMID:33645892 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP [Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein] CTD PMID:17377112 PMID:31618080 PMID:33645892 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions
increases expression
EXP Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein] CTD PMID:33645892 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253
JBrowse link
G Vim vimentin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein] CTD PMID:33645892 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
6-acetylmorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase increases chemical synthesis
multiple interactions
increases degradation
ISO ACHE protein results in increased chemical synthesis of 6-O-monoacetylmorphine
[ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine; [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine
CTD PMID:30080993 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases chemical synthesis
increases degradation
ISO [BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine; [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine
BCHE protein results in increased chemical synthesis of 6-O-monoacetylmorphine
CTD PMID:30080993 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
G Ces1d carboxylesterase 1D affects binding
multiple interactions
increases chemical synthesis
ISO 6-O-monoacetylmorphine binds to CES1 protein
Cocaine inhibits the reaction [CES1 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]
CTD PMID:8930175 PMID:9311626 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis
multiple interactions
increases chemical synthesis
ISO CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine
Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of 6-O-monoacetylmorphine]; Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of 6-O-monoacetylmorphine]
CTD PMID:8930175 PMID:9169443 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
alfentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyb5a cytochrome b5 type A multiple interactions ISO CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]; CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344 NCBI chr18:80,487,923...80,520,544
Ensembl chr18:14,453,966...14,455,094
Ensembl chr18:14,453,966...14,455,094
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions
ISO CYP3A4 protein affects the metabolism of Alfentanil
CYB5A protein promotes the reaction [CYP3A4 protein affects the metabolism of Alfentanil]
CTD PMID:15557344 PMID:15731592 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
affects metabolic processing
ISO CYB5A protein promotes the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Ketoconazole inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil]; Troleandomycin inhibits the reaction [CYP3A5 protein affects the metabolism of Alfentanil] CTD PMID:15557344 PMID:15731592 PMID:17554244 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Alfentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
JBrowse link
buprenorphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor decreases expression EXP Buprenorphine results in decreased expression of BDNF protein CTD PMID:24321744 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP
ISO
Buprenorphine results in decreased activity of CAT protein
[2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Buprenorphine] results in increased activity of CAT protein
CTD PMID:25683329 PMID:32113805 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of CREB1 protein CTD PMID:24321744 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing ISO CYP2C8 protein affects the metabolism of Buprenorphine CTD PMID:16010532
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
ISO CYP2D6 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP2D6 protein
CTD PMID:12756210 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
decreases alkylation
increases metabolic processing
decreases activity
ISO CYP3A4 protein affects the metabolism of Buprenorphine
CYP3A4 protein results in decreased alkylation of Buprenorphine
CYP3A4 protein results in increased metabolism of Buprenorphine
Buprenorphine results in decreased activity of CYP3A4 protein
CTD PMID:12756210 PMID:15966752 PMID:16010532 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Buprenorphine results in increased activity of GPT protein CTD PMID:25683329 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Il2 interleukin 2 decreases expression ISO Buprenorphine results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il4 interleukin 4 increases expression ISO Buprenorphine results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Buprenorphine results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 decreases phosphorylation EXP Buprenorphine results in decreased phosphorylation of NTRK2 protein CTD PMID:24321744 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRD1 protein
Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]
CTD PMID:7562497 PMID:21866885 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP
ISO
Buprenorphine binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]
CTD PMID:7562497 PMID:21866885 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO Buprenorphine binds to and results in increased activity of OPRL1 protein CTD PMID:10998549 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:189,212,175...189,217,426
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
Buprenorphine binds to and affects the activity of OPRM1 protein; Buprenorphine binds to and results in increased activity of OPRM1 protein; Buprenorphine inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]
Buprenorphine binds to OPRM1 protein
CTD PMID:7562497 PMID:16010532 PMID:21866885 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha decreases activity EXP Buprenorphine results in decreased activity of PRKACA protein CTD PMID:24321744 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Buprenorphine CTD PMID:12756209 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
butorphanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects activity EXP Butorphanol affects the activity of OPRD1 protein CTD PMID:17909753 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity EXP Butorphanol affects the activity of OPRK1 protein CTD PMID:17909753 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 affects activity
increases activity
ISO
EXP
Butorphanol affects the activity of OPRM1 protein
Butorphanol results in increased activity of OPRM1 protein
CTD PMID:17909753 PMID:32734307 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Prkcd protein kinase C, delta affects localization ISO Butorphanol affects the localization of PRKCD protein CTD PMID:29669290 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839
JBrowse link
carfentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing ISO CYP2C8 protein results in increased metabolism of carfentanil CTD PMID:33652071
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of carfentanil CTD PMID:33652071 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO CYP3A5 protein results in increased metabolism of carfentanil CTD PMID:33652071 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO Capsaicin inhibits the reaction [carfentanil binds to OPRM1 protein]; Cocaine affects the reaction [carfentanil binds to OPRM1 protein] CTD PMID:12406535 PMID:15953495 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
codeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO Codeine results in increased secretion of CCL2 protein CTD PMID:17441793 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Codeine affects the secretion of and affects the expression of CCL5 protein CTD PMID:17441793 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Codeine analog CTD PMID:25445008 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
multiple interactions
increases metabolic processing
affects response to substance
decreases methylation
ISO CYP2D6 protein affects the metabolism of Codeine; CYP2D6 protein polymorphism affects the metabolism of Codeine
[CYP2D6 gene mutant form results in increased activity of CYP2D6 protein] which results in increased susceptibility to Codeine; [CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
[CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CYP2D6 protein polymorphism affects the susceptibility to Codeine
CYP2D6 protein results in decreased methylation of Codeine
CYP2D6 gene polymorphism results in increased metabolism of Codeine; CYP2D6 protein results in increased metabolism of Codeine
CTD PMID:9696456 PMID:10911933 PMID:11823760 PMID:15286053 PMID:15625333 More... NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
ISO CYP3A4 protein affects the metabolism of Codeine
CYP3A4 protein results in increased metabolism of Codeine
[CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine
CTD PMID:15286053 PMID:16595712 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Codeine results in decreased activity of KCNH2 protein CTD PMID:19034038 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Codeine binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Codeine binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Codeine binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
codeinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO 6-codeinone results in increased expression of BAX protein CTD PMID:12894543 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 6-codeinone results in decreased expression of BCL2 protein CTD PMID:12894543 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
ISO 6-codeinone results in increased activity of CASP3 protein
6-codeinone results in increased cleavage of CASP3 protein
CTD PMID:12606908 PMID:12894543 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp9 caspase 9 increases activity ISO 6-codeinone results in increased activity of CASP9 protein CTD PMID:12894543 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cycs cytochrome c, somatic affects localization ISO 6-codeinone affects the localization of CYCS protein CTD PMID:12894543 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816
JBrowse link
DADLE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator multiple interactions ISO Enkephalin, Leucine-2-Alanine promotes the reaction [Isoproterenol results in increased activity of CFTR protein] CTD PMID:15151902 NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:47,526,735...47,694,643
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions ISO Endocannabinoids inhibits the reaction [Enkephalin, Leucine-2-Alanine binds to and results in increased activity of OPRD1 protein]; Enkephalin, Leucine-2-Alanine binds to and results in increased activity of OPRD1 protein CTD PMID:30102254 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]; Naltrexone inhibits the reaction [Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]] CTD PMID:9765353 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
JBrowse link
dextropropoxyphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567
JBrowse link
G Ces1d carboxylesterase 1D affects binding ISO Dextropropoxyphene binds to CES1 protein CTD PMID:10381793 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449
JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Dextropropoxyphene binds to CES2 protein CTD PMID:10381793 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dextropropoxyphene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
DPDPE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 affects export EXP ABCC2 protein affects the export of Enkephalin, D-Penicillamine (2,5)- CTD PMID:15528320 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Enkephalin, D-Penicillamine (2,5)- CTD PMID:11880531 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:169,183,194...169,193,745
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases secretion ISO HNF4A protein results in increased secretion of Enkephalin, D-Penicillamine (2,5)- CTD PMID:27160211 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:172,606,220...172,667,758
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding
increases expression
EXP
ISO
[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum; [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine; naltrindole inhibits the reaction [[Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in increased susceptibility to Cocaine]
7-hydroxymitragynine affects the reaction [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein]; Buprenorphine inhibits the reaction [Enkephalin, D-Penicillamine (2,5)- analog binds to OPRD1 protein]; Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein
Enkephalin, D-Penicillamine (2,5)- binds to OPRD1 protein
Enkephalin, D-Penicillamine (2,5)- results in increased expression of OPRD1 mRNA
CTD PMID:7477890 PMID:7562497 PMID:9302088 PMID:19279569 PMID:21866885 More... NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Enkephalin, D-Penicillamine (2,5)- binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Enkephalin, D-Penicillamine (2,5)- binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 affects uptake EXP SLCO1A1 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)- CTD PMID:15528320 NCBI chr 4:174,877,045...174,950,900
Ensembl chr 4:176,607,687...176,681,992
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects transport
affects uptake
ISO
EXP
SLCO1A4 protein affects the transport of Enkephalin, D-Penicillamine (2,5)-
SLCO1A4 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)-
CTD PMID:15528320 PMID:19833843 NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:176,441,104...176,495,816
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects uptake EXP SLCO1B2 protein affects the uptake of Enkephalin, D-Penicillamine (2,5)- CTD PMID:15528320 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083
JBrowse link
eluxadoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to eluxadoline CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
etonitazene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions EXP [etonitazene analog binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; [etonitazene binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein CTD PMID:35449307 PMID:35477798 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP etonitazene analog binds to OPRD1 protein CTD PMID:35477798 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP etonitazene analog binds to OPRK1 protein CTD PMID:35477798 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 increases phosphorylation
multiple interactions
ISO
EXP
etonitazene results in increased phosphorylation of OPRM1 protein
[etonitazene analog binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; [etonitazene binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; etonitazene analog binds to and results in increased activity of OPRM1 protein; etonitazene binds to and results in increased activity of OPRM1 protein
CTD PMID:21957251 PMID:35449307 PMID:35477798 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
fentanyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
increases response to substance
ISO
EXP
ABCB1 protein results in increased transport of Fentanyl
tariquidar inhibits the reaction [ABCB1 protein results in increased transport of Fentanyl]
ABCB1 protein results in increased susceptibility to Fentanyl
CTD PMID:29669042 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Acan aggrecan decreases expression EXP Fentanyl results in decreased expression of ACAN mRNA CTD PMID:36032789 NCBI chr 1:142,390,951...142,453,779
Ensembl chr 1:142,390,951...142,453,779
JBrowse link
G Adamts14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 decreases expression EXP Fentanyl results in decreased expression of ADAMTS14 mRNA CTD PMID:36032789 NCBI chr20:29,143,029...29,219,846
Ensembl chr20:29,685,876...29,762,682
JBrowse link
G Adamtsl3 ADAMTS-like 3 affects expression EXP Fentanyl affects the expression of ADAMTSL3 mRNA CTD PMID:36032789 NCBI chr 1:145,698,004...146,006,195
Ensembl chr 1:145,698,004...146,006,195
JBrowse link
G Akap5 A-kinase anchoring protein 5 increases expression EXP Fentanyl results in increased expression of AKAP5 mRNA CTD PMID:36032789 NCBI chr 6:100,787,169...100,796,712
Ensembl chr 6:100,790,148...100,796,620
JBrowse link
G Apln apelin decreases expression EXP Fentanyl results in decreased expression of APLN mRNA CTD PMID:36032789 NCBI chr  X:127,180,801...127,213,567
Ensembl chr  X:132,081,759...132,091,246
JBrowse link
G Arrb2 arrestin, beta 2 affects localization
multiple interactions
ISO
EXP
Fentanyl affects the localization of ARRB2 protein
[Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein
CTD PMID:27030709 PMID:35477798 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487
JBrowse link
G Bdnf brain-derived neurotrophic factor affects expression EXP Fentanyl affects the expression of BDNF mRNA CTD PMID:36032789 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Bgn biglycan affects expression EXP Fentanyl affects the expression of BGN mRNA CTD PMID:36032789 NCBI chr  X:156,348,633...156,360,797
Ensembl chr  X:156,348,615...156,360,799
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases expression EXP Fentanyl results in increased expression of BIRC3 mRNA CTD PMID:36032789 NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:13,285,703...13,298,590
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 increases expression EXP Fentanyl results in increased expression of BST2 mRNA CTD PMID:36032789 NCBI chr16:18,250,593...18,254,967
Ensembl chr16:18,251,847...18,254,967
JBrowse link
G C3 complement C3 increases expression EXP Fentanyl results in increased expression of C3 mRNA CTD PMID:36032789 NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,174,412...2,201,339
JBrowse link
G Cacna1e calcium voltage-gated channel subunit alpha1 E affects expression EXP Fentanyl affects the expression of CACNA1E mRNA CTD PMID:36032789 NCBI chr13:69,125,048...69,613,795
Ensembl chr13:69,132,305...69,612,983
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]] CTD PMID:27030709 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
JBrowse link
G Cckbr cholecystokinin B receptor decreases expression EXP Fentanyl results in decreased expression of CCKBR mRNA CTD PMID:36032789 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:169,183,194...169,193,745
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression EXP Fentanyl results in increased expression of CCL2 mRNA CTD PMID:36032789 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression EXP Fentanyl results in increased expression of CCL20 mRNA CTD PMID:36032789 NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:91,836,946...91,839,736
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression EXP Fentanyl results in increased expression of CCL7 mRNA CTD PMID:36032789 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947
JBrowse link
G Cfb complement factor B increases expression EXP Fentanyl results in increased expression of CFB mRNA CTD PMID:36032789 NCBI chr20:3,975,271...3,981,138
Ensembl chr20:3,955,776...3,981,740
JBrowse link
G Chi3l1 chitinase 3 like 1 increases expression EXP Fentanyl results in increased expression of CHI3L1 mRNA CTD PMID:36032789 NCBI chr13:48,193,839...48,201,822
Ensembl chr13:48,193,800...48,201,825
JBrowse link
G Clstn2 calsyntenin 2 affects expression EXP Fentanyl affects the expression of CLSTN2 mRNA CTD PMID:36032789 NCBI chr 8:98,020,406...98,637,232
Ensembl chr 8:106,899,894...107,040,053
JBrowse link
G Cntf ciliary neurotrophic factor increases expression EXP Fentanyl results in increased expression of CNTF mRNA CTD PMID:36032789 NCBI chr 1:219,312,512...219,314,535
Ensembl chr 1:219,312,512...219,314,488
JBrowse link
G Col15a1 collagen type XV alpha 1 chain increases expression EXP Fentanyl results in increased expression of COL15A1 mRNA CTD PMID:36032789 NCBI chr 5:66,297,546...66,403,172
Ensembl chr 5:66,297,461...66,403,170
JBrowse link
G Col26a1 collagen type XXVI alpha 1 chain increases expression EXP Fentanyl results in increased expression of COL26A1 mRNA CTD PMID:36032789 NCBI chr12:19,792,693...19,938,556
Ensembl chr12:25,429,387...25,575,206
JBrowse link
G Col3a1 collagen type III alpha 1 chain affects expression EXP Fentanyl affects the expression of COL3A1 mRNA CTD PMID:36032789 NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:54,866,632...54,903,232
JBrowse link
G Crh corticotropin releasing hormone affects expression
increases expression
EXP Fentanyl affects the expression of CRH mRNA
Fentanyl results in increased expression of CRH mRNA
CTD PMID:18819432 PMID:36032789 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Crlf1 cytokine receptor-like factor 1 affects expression EXP Fentanyl affects the expression of CRLF1 mRNA CTD PMID:36032789 NCBI chr16:18,924,722...18,936,049
Ensembl chr16:18,957,956...18,969,970
JBrowse link
G Csf1 colony stimulating factor 1 increases expression EXP Fentanyl results in increased expression of CSF1 mRNA CTD PMID:36032789 NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:198,065,405...198,084,468
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Fentanyl results in increased expression of CXCL1 mRNA CTD PMID:36032789 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases expression EXP Fentanyl results in increased expression of CXCL10 mRNA CTD PMID:36032789 NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,989,018...15,991,261
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression EXP Fentanyl results in increased expression of CXCL11 mRNA CTD PMID:36032789 NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,973,720...15,976,567
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression EXP Fentanyl results in increased expression of CXCL12 mRNA CTD PMID:36032789 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:152,060,780...152,073,627
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 increases expression EXP Fentanyl results in increased expression of CXCL13 mRNA CTD PMID:36032789 NCBI chr14:13,912,858...13,917,920
Ensembl chr14:13,912,858...13,917,920
JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 increases expression EXP Fentanyl results in increased expression of CXCL16 mRNA CTD PMID:36032789 NCBI chr10:55,665,355...55,669,950
Ensembl chr10:55,664,742...55,670,226
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Fentanyl results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Fentanyl CTD PMID:11811955 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Dcn decorin increases expression EXP Fentanyl results in increased expression of DCN mRNA CTD PMID:36032789 NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:34,163,011...34,218,926
JBrowse link
G Ednrb endothelin receptor type B decreases expression EXP Fentanyl results in decreased expression of EDNRB mRNA CTD PMID:36032789 NCBI chr15:87,055,490...87,086,765
Ensembl chr15:87,057,691...87,086,765
JBrowse link
G Fbln5 fibulin 5 decreases expression EXP Fentanyl results in decreased expression of FBLN5 mRNA CTD PMID:36032789 NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:126,664,100...126,746,296
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases expression EXP Fentanyl results in increased expression of FGR mRNA CTD PMID:36032789 NCBI chr 5:150,473,767...150,503,524
Ensembl chr 5:150,473,792...150,503,169
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Fentanyl results in increased expression of FOS protein CTD PMID:7970238 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Gast gastrin multiple interactions EXP [fluanisone co-treated with Fentanyl co-treated with Midazolam] inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,765,216...85,767,880
JBrowse link
G Gbp2 guanylate binding protein 2 increases expression EXP Fentanyl results in increased expression of GBP2 mRNA CTD PMID:36032789 NCBI chr 2:234,005,727...234,021,812
Ensembl chr 2:234,008,590...234,021,810
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist decreases expression EXP Fentanyl results in decreased expression of GREM1 mRNA CTD PMID:36032789 NCBI chr 3:120,966,639...120,978,319
Ensembl chr 3:120,966,623...120,979,089
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A affects expression EXP Fentanyl affects the expression of GRIN2A mRNA CTD PMID:36032789 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B affects expression EXP Fentanyl affects the expression of GRIN2B mRNA CTD PMID:36032789 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
JBrowse link
G Grm1 glutamate metabotropic receptor 1 affects expression EXP Fentanyl affects the expression of GRM1 mRNA CTD PMID:36032789 NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443
JBrowse link
G Grm3 glutamate metabotropic receptor 3 affects expression EXP Fentanyl affects the expression of GRM3 mRNA CTD PMID:36032789 NCBI chr 4:25,319,218...25,600,721
Ensembl chr 4:25,319,942...25,564,764
JBrowse link
G Has1 hyaluronan synthase 1 decreases expression EXP Fentanyl results in decreased expression of HAS1 mRNA CTD PMID:36032789 NCBI chr 1:67,366,460...67,378,686
Ensembl chr 1:67,366,460...67,378,444
JBrowse link
G Hcrtr1 hypocretin receptor 1 decreases expression EXP Fentanyl results in decreased expression of HCRTR1 mRNA CTD PMID:36032789 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:147,760,145...147,770,850
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A affects expression EXP Fentanyl affects the expression of HTR2A mRNA CTD PMID:36032789 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 increases expression EXP Fentanyl results in increased expression of IFIT3 mRNA CTD PMID:36032789 NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Fentanyl results in increased expression of IL1A mRNA CTD PMID:36032789 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il2 interleukin 2 decreases expression ISO Fentanyl results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il4 interleukin 4 increases expression ISO Fentanyl results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il7 interleukin 7 increases expression EXP Fentanyl results in increased expression of IL7 mRNA CTD PMID:36032789 NCBI chr 2:96,142,523...96,186,282
Ensembl chr 2:96,142,092...96,187,389
JBrowse link
G Irf7 interferon regulatory factor 7 increases expression EXP Fentanyl results in increased expression of IRF7 mRNA CTD PMID:36032789 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression EXP Fentanyl results in increased expression of ISG15 mRNA CTD PMID:36032789 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656
JBrowse link
G Itga11 integrin subunit alpha 11 increases expression EXP Fentanyl results in increased expression of ITGA11 mRNA CTD PMID:36032789 NCBI chr 8:72,041,432...72,150,137
Ensembl chr 8:72,016,652...72,150,137
JBrowse link
G Itgal integrin subunit alpha L increases expression EXP Fentanyl results in increased expression of ITGAL mRNA CTD PMID:36032789 NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:191,348,542...191,386,225
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fentanyl results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression EXP Fentanyl results in decreased expression of LAMB3 mRNA CTD PMID:36032789 NCBI chr13:107,362,514...107,404,081
Ensembl chr13:107,322,526...107,404,081
JBrowse link
G Lamc2 laminin subunit gamma 2 affects expression EXP Fentanyl affects the expression of LAMC2 mRNA CTD PMID:36032789 NCBI chr13:67,835,199...67,894,694
Ensembl chr13:67,835,199...67,895,102
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Fentanyl results in increased expression of LCN2 mRNA CTD PMID:36032789 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842
JBrowse link
G Lox lysyl oxidase decreases expression EXP Fentanyl results in decreased expression of LOX mRNA CTD PMID:36032789 NCBI chr18:48,162,889...48,175,640
Ensembl chr18:48,165,688...48,239,810
JBrowse link
G Loxl1 lysyl oxidase-like 1 increases expression EXP Fentanyl results in increased expression of LOXL1 mRNA CTD PMID:36032789 NCBI chr 8:67,587,636...67,612,224
Ensembl chr 8:67,587,636...67,612,224
JBrowse link
G Loxl2 lysyl oxidase-like 2 decreases expression EXP Fentanyl results in decreased expression of LOXL2 mRNA CTD PMID:36032789 NCBI chr15:44,683,449...44,773,067
Ensembl chr15:51,069,997...51,182,842
JBrowse link
G Ltb lymphotoxin beta increases expression EXP Fentanyl results in increased expression of LTB mRNA CTD PMID:36032789 NCBI chr20:3,632,209...3,634,054
Ensembl chr20:3,632,210...3,634,054
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fentanyl results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor decreases expression EXP Fentanyl results in decreased expression of MAS1 mRNA CTD PMID:36032789 NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:50,425,257...50,500,561
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP Fentanyl results in increased expression of MMP2 mRNA CTD PMID:36032789 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression EXP Fentanyl results in decreased expression of MMP9 mRNA CTD PMID:36032789 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mx1 MX dynamin like GTPase 1 increases expression EXP Fentanyl results in increased expression of MX1 mRNA CTD PMID:36032789 NCBI chr11:50,269,056...50,294,699
Ensembl chr11:50,269,057...50,292,904
JBrowse link
G Mx2 MX dynamin like GTPase 2 increases expression EXP Fentanyl results in increased expression of MX2 mRNA CTD PMID:36032789 NCBI chr11:50,375,101...50,399,373
Ensembl chr11:50,375,191...50,402,478
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO
EXP
Fentanyl results in increased expression of NFKBIA protein
Fentanyl results in increased expression of NFKBIA mRNA
CTD PMID:22258905 PMID:36032789 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nid2 nidogen 2 decreases expression EXP Fentanyl results in decreased expression of NID2 mRNA CTD PMID:36032789 NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,506,756...4,562,949
JBrowse link
G Nppc natriuretic peptide C affects expression EXP Fentanyl affects the expression of NPPC mRNA CTD PMID:36032789 NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:94,767,986...94,772,186
JBrowse link
G Nts neurotensin decreases expression EXP Fentanyl results in decreased expression of NTS mRNA CTD PMID:36032789 NCBI chr 7:39,451,484...39,460,888
Ensembl chr 7:39,451,073...39,460,961
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like increases expression EXP Fentanyl results in increased expression of OASL mRNA CTD PMID:36032789 NCBI chr12:47,343,551...47,356,509
Ensembl chr12:47,343,551...47,356,483
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Fentanyl binds to OPRD1 protein CTD PMID:35477798 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Fentanyl binds to OPRK1 protein CTD PMID:35477798 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 increases phosphorylation
multiple interactions
ISO
EXP
Fentanyl results in increased phosphorylation of OPRM1 protein
[Fentanyl binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Fentanyl binds to and results in increased activity of OPRM1 protein
CTD PMID:17240843 PMID:21957251 PMID:23300227 PMID:35477798 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 decreases expression EXP Fentanyl results in decreased expression of P4HA2 mRNA CTD PMID:36032789 NCBI chr10:38,243,136...38,271,983
Ensembl chr10:38,743,894...38,772,993
JBrowse link
G Pdyn prodynorphin increases expression EXP Fentanyl results in increased expression of PDYN protein CTD PMID:19200067 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503
JBrowse link
G Pf4 platelet factor 4 increases expression EXP Fentanyl results in increased expression of PF4 mRNA CTD PMID:36032789 NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,582,477...17,583,392
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Fentanyl results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435
JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions
ISO Fentanyl results in decreased expression of POMC protein alternative form
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form
CTD PMID:20084599 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
G Prlhr prolactin releasing hormone receptor decreases expression EXP Fentanyl results in decreased expression of PRLHR mRNA CTD PMID:36032789 NCBI chr 1:259,606,704...259,608,391
Ensembl chr 1:269,585,611...269,594,909
JBrowse link
G Psmb9 proteasome 20S subunit beta 9 increases expression EXP Fentanyl results in increased expression of PSMB9 mRNA CTD PMID:36032789 NCBI chr20:4,668,952...4,674,421
Ensembl chr20:4,668,739...4,674,421
JBrowse link
G Pthlh parathyroid hormone-like hormone affects expression EXP Fentanyl affects the expression of PTHLH mRNA CTD PMID:36032789 NCBI chr 4:181,919,400...181,930,454
Ensembl chr 4:181,919,400...181,930,454
JBrowse link
G Ptx3 pentraxin 3 increases expression EXP Fentanyl results in increased expression of PTX3 mRNA CTD PMID:36032789 NCBI chr 2:152,797,563...152,803,372
Ensembl chr 2:152,781,955...152,803,372
JBrowse link
G Reln reelin increases expression EXP Fentanyl results in increased expression of RELN mRNA CTD PMID:36032789 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162
JBrowse link
G Ren renin multiple interactions ISO [Fentanyl co-treated with Isoflurane] results in decreased expression of REN protein CTD PMID:3284271 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression EXP Fentanyl results in increased expression of S100A8 mRNA CTD PMID:36032789 NCBI chr 2:178,464,095...178,465,223
Ensembl chr 2:178,464,702...178,465,221
JBrowse link
G Scg2 secretogranin II affects expression EXP Fentanyl affects the expression of SCG2 mRNA CTD PMID:36032789 NCBI chr 9:88,251,531...88,257,208
Ensembl chr 9:88,251,354...88,269,598
JBrowse link
G Sema3a semaphorin 3A decreases expression EXP Fentanyl results in decreased expression of SEMA3A mRNA CTD PMID:36032789 NCBI chr 4:22,239,418...22,709,907
Ensembl chr 4:22,245,322...22,535,774
JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression EXP Fentanyl results in increased expression of SLC11A1 mRNA CTD PMID:36032789 NCBI chr 9:83,406,327...83,417,252
Ensembl chr 9:83,406,427...83,417,238
JBrowse link
G Slc8a2 solute carrier family 8 member A2 affects expression EXP Fentanyl affects the expression of SLC8A2 mRNA CTD PMID:36032789 NCBI chr 1:85,944,752...85,982,900
Ensembl chr 1:85,947,204...85,981,889
JBrowse link
G Sod2 superoxide dismutase 2 increases expression EXP Fentanyl results in increased expression of SOD2 mRNA CTD PMID:36032789 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 decreases expression EXP Fentanyl results in decreased expression of SORCS3 mRNA CTD PMID:36032789 NCBI chr 1:247,099,178...247,734,027
Ensembl chr 1:257,040,473...257,675,259
JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression EXP Fentanyl affects the expression of SPP1 mRNA CTD PMID:36032789 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
JBrowse link
G Tlr2 toll-like receptor 2 increases expression EXP Fentanyl results in increased expression of TLR2 mRNA CTD PMID:36032789 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
JBrowse link
G Tnfrsf9 TNF receptor superfamily member 9 increases expression EXP Fentanyl results in increased expression of TNFRSF9 mRNA CTD PMID:36032789 NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:166,664,494...166,690,831
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP Fentanyl results in increased expression of VCAM1 mRNA CTD PMID:36032789 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression EXP Fentanyl results in decreased expression of VEGFA mRNA CTD PMID:36032789 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vgf VGF nerve growth factor inducible affects expression EXP Fentanyl affects the expression of VGF mRNA CTD PMID:36032789 NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703
JBrowse link
G Wnt10a Wnt family member 10A affects expression EXP Fentanyl affects the expression of WNT10A mRNA CTD PMID:36032789 NCBI chr 9:83,798,594...83,811,060
Ensembl chr 9:83,798,594...83,811,067
JBrowse link
heroin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases metabolic processing
ISO [ACHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Actn2 actinin alpha 2 decreases expression ISO Heroin results in decreased expression of ACTN2 mRNA CTD PMID:16710320 NCBI chr17:62,835,055...62,902,331
Ensembl chr17:62,812,988...62,903,552
JBrowse link
G Amph amphiphysin decreases expression ISO Heroin results in decreased expression of AMPH mRNA CTD PMID:16710320 NCBI chr17:45,739,385...45,982,905
Ensembl chr17:50,435,018...50,678,501
JBrowse link
G App amyloid beta precursor protein decreases expression ISO Heroin results in decreased expression of APP mRNA CTD PMID:16710320 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases metabolic processing
ISO [BCHE protein results in increased metabolism of Heroin] which results in increased chemical synthesis of 6-O-monoacetylmorphine CTD PMID:30080993 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression
multiple interactions
ISO
EXP
Heroin results in decreased expression of BDNF protein
Heroin results in decreased expression of BDNF mRNA
Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
CTD PMID:17715210 PMID:25643298 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Bloc1s6 biogenesis of lysosomal organelles complex 1 subunit 6 decreases expression ISO Heroin results in decreased expression of BLOC1S6 mRNA CTD PMID:16710320 NCBI chr 3:109,816,397...109,826,528
Ensembl chr 3:130,268,442...130,281,360
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [Heroin co-treated with Cocaine] results in increased activity of CASP3 protein; Heroin promotes the reaction [Cocaine results in increased activity of CASP3 protein] CTD PMID:20600547 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Ces1d carboxylesterase 1D decreases acetylation
increases hydrolysis
multiple interactions
affects binding
ISO CES1 protein results in decreased acetylation of Heroin
CES1 protein results in increased hydrolysis of Heroin
Cocaine inhibits the reaction [CES1 protein results in increased hydrolysis of Heroin]
Heroin binds to CES1 protein
CTD PMID:8930175 PMID:9311626 PMID:12679808 PMID:12773168 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
ISO Cocaine inhibits the reaction [CES2 protein results in increased hydrolysis of Heroin] CTD PMID:8930175 PMID:9169443 PMID:25445008 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Churc1 churchill domain containing 1 decreases expression ISO Heroin results in decreased expression of CHURC1 mRNA CTD PMID:16710320 NCBI chr 6:101,203,778...101,218,364
Ensembl chr 6:101,203,841...101,237,748
JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression
multiple interactions
EXP Heroin results in increased expression of CNR1 mRNA; Heroin results in increased expression of CNR1 protein
Cannabidiol inhibits the reaction [Heroin results in increased expression of CNR1 mRNA]; Cannabidiol inhibits the reaction [Heroin results in increased expression of CNR1 protein]
CTD PMID:19940171 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP Heroin inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]
heroin increases phosphorylation of Creb1 protein in brain
CTD
RGD
PMID:25643298 PMID:21362452 RGD:401901181 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Heroin results in decreased activity of CYP1A2 protein CTD PMID:35914676 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Heroin results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases activity ISO Heroin results in increased activity of CYP2D6 protein CTD PMID:35914676 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Deaf1 DEAF1 transcription factor decreases expression ISO Heroin results in decreased expression of DEAF1 mRNA CTD PMID:16710320 NCBI chr 1:196,401,857...196,435,541
Ensembl chr 1:205,831,336...205,865,106
JBrowse link
G Dnph1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression ISO Heroin results in decreased expression of DNPH1 mRNA CTD PMID:16710320 NCBI chr 9:21,978,894...21,981,631
Ensembl chr 9:21,978,894...21,981,631
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO Heroin results in decreased expression of DRD2 protein CTD PMID:11126397 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A decreases expression ISO Heroin results in decreased expression of EIF5A mRNA CTD PMID:16710320 NCBI chr10:55,138,821...55,143,272
Ensembl chr10:55,138,823...55,143,330
JBrowse link
G Enho energy homeostasis associated decreases expression ISO Heroin results in decreased expression of ENHO mRNA CTD PMID:16710320 NCBI chr 5:56,800,980...56,802,777
Ensembl chr 5:61,596,860...61,598,657
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Heroin results in increased expression of FAS mRNA CTD PMID:16710320 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Heroin results in increased expression of FOS mRNA; Heroin results in increased expression of FOS protein
Dronabinol affects the reaction [Heroin results in increased expression of FOS protein]
CTD PMID:16137723 PMID:19169671 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP heroin decreases expression of Fosb protein in brain RGD PMID:21362452 RGD:401901181 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression ISO Heroin results in increased expression of GPT protein CTD PMID:36502556 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Grm5 glutamate metabotropic receptor 5 multiple interactions
decreases expression
EXP Cannabidiol inhibits the reaction [Heroin results in decreased expression of GRM5 mRNA]; Cannabidiol inhibits the reaction [Heroin results in decreased expression of GRM5 protein]
Heroin results in decreased expression of GRM5 mRNA; Heroin results in decreased expression of GRM5 protein
CTD PMID:19940171 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IFNG protein CTD PMID:16766138 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL10 protein CTD PMID:16766138 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL2 protein CTD PMID:16766138 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il4 interleukin 4 multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of IL4 protein CTD PMID:16766138 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Itgb1bp1 integrin subunit beta 1 binding protein 1 increases expression ISO Heroin results in increased expression of ITGB1BP1 mRNA CTD PMID:16710320 NCBI chr 6:46,549,994...46,564,735
Ensembl chr 6:46,549,999...46,564,398
JBrowse link
G Ngf nerve growth factor decreases expression ISO Heroin results in decreased expression of NGF protein CTD PMID:17715210 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:192,589,582...192,643,834
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP Heroin results in decreased expression of NR4A2 mRNA CTD PMID:25643298 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Heroin results in increased expression of NTRK2 mRNA CTD PMID:16710320 NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,564,570...5,874,628
JBrowse link
G Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 decreases expression ISO Heroin results in decreased expression of NUCKS1 mRNA CTD PMID:16710320 NCBI chr13:45,897,275...45,926,491
Ensembl chr13:45,897,248...45,923,101
JBrowse link
G Pde4dip phosphodiesterase 4D interacting protein increases expression ISO Heroin results in increased expression of PDE4DIP mRNA CTD PMID:16710320 NCBI chr 2:187,982,002...188,178,937
Ensembl chr 2:187,981,878...188,178,869
JBrowse link
G Pdyn prodynorphin decreases expression
increases expression
ISO
EXP
Heroin results in decreased expression of PDYN mRNA
Heroin results in increased expression of PDYN mRNA
CTD PMID:16710320 PMID:19100723 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression ISO Heroin results in decreased expression of PMEPA1 mRNA CTD PMID:16710320 NCBI chr 3:182,430,193...182,478,649
Ensembl chr 3:182,430,193...182,478,649
JBrowse link
G Prepl prolyl endopeptidase-like decreases expression ISO Heroin results in decreased expression of PREPL mRNA CTD PMID:16710320 NCBI chr 6:15,333,107...15,362,825
Ensembl chr 6:15,333,077...15,363,231
JBrowse link
G Septin4 septin 4 increases expression ISO Heroin results in increased expression of SEPTIN4 mRNA CTD PMID:16710320 NCBI chr10:72,863,969...72,888,018
Ensembl chr10:72,864,014...72,888,019
JBrowse link
G Slc25a23 solute carrier family 25 member 23 decreases expression ISO Heroin results in decreased expression of SLC25A23 mRNA CTD PMID:16710320 NCBI chr 9:1,969,633...1,985,365
Ensembl chr 9:1,969,357...1,985,365
JBrowse link
G Slc25a37 solute carrier family 25 member 37 increases expression ISO Heroin results in increased expression of SLC25A37 mRNA CTD PMID:16710320 NCBI chr15:44,534,280...44,576,697
Ensembl chr15:50,946,236...50,986,808
JBrowse link
G Snap25 synaptosome associated protein 25 decreases expression ISO Heroin results in decreased expression of SNAP25 mRNA CTD PMID:16710320 NCBI chr 3:144,494,579...144,576,449
Ensembl chr 3:144,494,595...144,576,448
JBrowse link
G Stxbp1 syntaxin binding protein 1 decreases expression ISO Heroin results in decreased expression of STXBP1 mRNA CTD PMID:16710320 NCBI chr 3:36,474,428...36,536,120
Ensembl chr 3:36,474,428...36,536,058
JBrowse link
G Stxbp6 syntaxin binding protein 6 decreases expression ISO Heroin results in decreased expression of STXBP6 mRNA CTD PMID:16710320 NCBI chr 6:61,920,756...62,157,405
Ensembl chr 6:67,650,556...67,884,725
JBrowse link
G Sv2a synaptic vesicle glycoprotein 2a decreases expression ISO Heroin results in decreased expression of SV2A mRNA CTD PMID:16710320 NCBI chr 2:183,741,489...183,757,290
Ensembl chr 2:186,430,345...186,448,065
JBrowse link
G Syngr3 synaptogyrin 3 decreases expression ISO Heroin results in decreased expression of SYNGR3 mRNA CTD PMID:16710320 NCBI chr10:13,710,553...13,715,309
Ensembl chr10:14,215,088...14,220,179
JBrowse link
G Syt1 synaptotagmin 1 decreases expression ISO Heroin results in decreased expression of SYT1 mRNA CTD PMID:16710320 NCBI chr 7:45,699,649...46,244,460
Ensembl chr 7:45,702,228...46,244,213
JBrowse link
G Tfrc transferrin receptor increases expression ISO Heroin results in increased expression of TFRC mRNA CTD PMID:16710320 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [Cocaine co-treated with Heroin] results in increased expression of TNF protein CTD PMID:16766138 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO Heroin results in decreased expression of UGCG mRNA CTD PMID:16710320 NCBI chr 5:78,828,006...78,860,725
Ensembl chr 5:78,828,006...78,860,417
JBrowse link
G Vti1b vesicle transport through interaction with t-SNAREs 1B decreases expression ISO Heroin results in decreased expression of VTI1B mRNA CTD PMID:16710320 NCBI chr 6:97,957,700...97,976,491
Ensembl chr 6:103,694,345...103,709,295
JBrowse link
hydrocodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprd1 opioid receptor, delta 1 affects binding EXP Hydrocodone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Hydrocodone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Hydrocodone binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
hydrocodone bitartrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 decreases expression
multiple interactions
EXP hydrocodone bitartrate decreases expression of Slc7a11 protein in nucleus accumbens and hippocampus
Ceftriaxone inhibits the reaction [hydrocodone bitartrate decreases expression of Slc7a11 protein in nucleus accumbens and hippocampus]
RGD PMID:29604365 PMID:29604365 RGD:598148157, RGD:598148157 NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:136,532,246...136,695,695
JBrowse link
hydromorphone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrb2 arrestin, beta 2 multiple interactions EXP [Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein CTD PMID:35449307 NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Hydromorphone affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity
multiple interactions
ISO
EXP
Hydromorphone results in increased activity of OPRM1 protein
[Hydromorphone binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; Hydromorphone binds to and results in increased activity of OPRM1 protein
CTD PMID:32734307 PMID:35449307 PMID:35477798 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
isotonitazene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Oprm1 opioid receptor, mu 1 increases activity ISO isotonitazene results in increased activity of OPRM1 protein CTD PMID:32734307 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
Leu-enkephalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpp3 dipeptidylpeptidase 3 increases cleavage
multiple interactions
ISO DPP3 protein results in increased cleavage of Enkephalin, Leucine
spinorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]; tynorphin inhibits the reaction [DPP3 protein results in increased cleavage of Enkephalin, Leucine]
CTD PMID:10873616 NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:211,634,068...211,658,310
JBrowse link
G Oprd1 opioid receptor, delta 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRD1 protein CTD PMID:26476280 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO Enkephalin, Leucine results in increased activity of OPRM1 protein CTD PMID:26476280 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression ISO Loperamide results in decreased expression of ABCB11 mRNA CTD PMID:35926757 NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:74,424,979...74,520,581
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects binding
decreases expression
multiple interactions
increases transport
affects response to substance
ISO Loperamide binds to ABCB1 protein
Loperamide results in decreased expression of ABCB1 mRNA
Loperamide inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]
ABCB1 protein results in increased transport of Loperamide
ABCB1A protein affects the susceptibility to Loperamide
CTD PMID:15502009 PMID:23976943 PMID:34719826 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Loperamide CTD PMID:15502009 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Loperamide results in decreased expression of ABCC2 mRNA CTD PMID:35926757 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression ISO Loperamide results in decreased expression of ABCG5 mRNA CTD PMID:35926757 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376
JBrowse link
G Ano1 anoctamin 1 decreases expression
multiple interactions
ISO Loperamide results in decreased expression of ANO1 mRNA; Loperamide results in decreased expression of ANO1 protein
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of ANO1 protein]
CTD PMID:37375548 NCBI chr 1:209,180,755...209,329,413
Ensembl chr 1:209,180,755...209,329,550
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of BCL2 mRNA]
Loperamide results in decreased expression of BCL2 mRNA
CTD PMID:34719826 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Cat catalase decreases expression EXP Loperamide results in decreased expression of CAT protein CTD PMID:30597669 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Loperamide results in increased expression of CDKN1A mRNA
Loperamide promotes the reaction [Doxorubicin results in increased expression of CDKN1A mRNA]
CTD PMID:34719826 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Ces2h carboxylesterase 2H decreases activity
multiple interactions
ISO Loperamide results in decreased activity of CES2 protein
[Loperamide results in decreased activity of CES2 protein] which results in increased susceptibility to Bisphenol A-Glycidyl Methacrylate
CTD PMID:15687373 PMID:21951919 PMID:28647665 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Ch25h cholesterol 25-hydroxylase increases expression ISO Loperamide results in increased expression of CH25H mRNA CTD PMID:35926757 NCBI chr 1:241,428,048...241,429,366
Ensembl chr 1:241,331,619...241,431,190
JBrowse link
G Ckb creatine kinase B multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Loperamide results in increased secretion of [CKM protein binds to CKB protein] CTD PMID:30597669 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO Loperamide results in increased expression of CYP7A1 mRNA CTD PMID:35926757 NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:24,174,505...24,184,202
JBrowse link
G Fabp6 fatty acid binding protein 6 increases expression ISO Loperamide results in increased expression of FABP6 mRNA CTD PMID:35926757 NCBI chr10:28,565,054...28,569,727
Ensembl chr10:28,565,054...28,573,058
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression ISO Loperamide results in increased expression of FDPS mRNA CTD PMID:35926757 NCBI chr 2:176,795,192...176,804,816
Ensembl chr 2:176,795,192...176,807,136
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases secretion EXP Loperamide results in increased secretion of GOT1 protein CTD PMID:30597669 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Loperamide results in increased expression of HMGCR mRNA CTD PMID:35926757 NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:29,720,553...29,754,533
JBrowse link
G Htr4 5-hydroxytryptamine receptor 4 multiple interactions
decreases expression
ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of HTR4 mRNA] CTD PMID:37375548 NCBI chr18:55,765,981...55,949,921
Ensembl chr18:58,036,277...58,219,622
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Loperamide results in increased expression of IDI1 mRNA CTD PMID:35926757 NCBI chr17:66,539,761...66,547,524
Ensembl chr17:66,539,763...66,547,524
JBrowse link
G Il2 interleukin 2 decreases expression ISO Loperamide results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il4 interleukin 4 increases expression ISO Loperamide results in increased expression of IL4 mRNA CTD PMID:23965172 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Lss lanosterol synthase increases expression ISO Loperamide results in increased expression of LSS mRNA CTD PMID:35926757 NCBI chr20:12,090,641...12,118,230
Ensembl chr20:12,073,543...12,118,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Loperamide results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 decreases expression
multiple interactions
ISO Loperamide results in decreased expression of MAPK8 mRNA
Loperamide promotes the reaction [Doxorubicin results in decreased expression of MAPK8 mRNA]
CTD PMID:34719826 NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression
ISO Loperamide promotes the reaction [Doxorubicin results in decreased expression of MTOR mRNA]
Loperamide results in decreased expression of MTOR mRNA
CTD PMID:34719826 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:164,167,928...164,277,435
JBrowse link
G Mvk mevalonate kinase increases expression ISO Loperamide results in increased expression of MVK mRNA CTD PMID:35926757 NCBI chr12:47,802,002...47,819,503
Ensembl chr12:47,802,002...47,819,503
JBrowse link
G Mylk myosin light chain kinase decreases expression
multiple interactions
ISO Loperamide results in decreased expression of MYLK mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of MYLK mRNA]
CTD PMID:37375548 NCBI chr11:79,288,243...79,535,450
Ensembl chr11:79,288,243...79,535,659
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Loperamide results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of NOS1 protein]; mosapride inhibits the reaction [Loperamide results in decreased expression of NOS1 protein] CTD PMID:37375548 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO [Loperamide co-treated with Rifampin] results in increased activity of NR1I2 protein CTD PMID:20869355 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO [Loperamide co-treated with PK 11195] results in decreased activity of NR1I3 protein alternative form; Loperamide binds to and results in decreased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
JBrowse link
G Oprd1 opioid receptor, delta 1 affects response to substance ISO OPRD1 protein affects the susceptibility to Loperamide CTD PMID:25261794 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Loperamide results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435
JBrowse link
G Ryr3 ryanodine receptor 3 decreases expression
multiple interactions
ISO Loperamide results in decreased expression of RYR3 mRNA
Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]; mosapride inhibits the reaction [Loperamide results in decreased expression of RYR3 mRNA]
CTD PMID:37375548 NCBI chr 3:119,886,129...120,433,465
Ensembl chr 3:119,885,878...120,433,677
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Loperamide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
G Slc51a solute carrier family 51 member A increases expression ISO Loperamide results in increased expression of SLC51A mRNA CTD PMID:35926757 NCBI chr11:81,804,141...81,818,539
Ensembl chr11:81,803,972...81,818,539
JBrowse link
G Sqle squalene epoxidase increases expression ISO Loperamide results in increased expression of SQLE mRNA CTD PMID:35926757 NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:92,757,409...92,773,050
JBrowse link
G Tnni3 troponin I3, cardiac type increases secretion EXP Loperamide results in increased secretion of TNNI3 protein CTD PMID:30597669 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253
JBrowse link
G Trpm7 transient receptor potential cation channel, subfamily M, member 7 multiple interactions
decreases expression
ISO Foeniculum vulgare fruit inhibits the reaction [Loperamide results in decreased expression of TRPM7 protein] CTD PMID:37375548 NCBI chr 3:134,499,617...134,588,113
Ensembl chr 3:134,499,617...134,588,113
JBrowse link
methadone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
affects activity
ISO Methadone results in increased expression of ABCB1 protein
Methadone affects the activity of ABCB1 protein
CTD PMID:19840843 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects activity
increases expression
EXP Methadone affects the activity of ABCB1B protein
Methadone results in increased expression of ABCB1B protein
CTD PMID:19840843 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:26,106,903...26,279,567
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO Methadone affects the localization of BAX protein CTD PMID:20691259 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Methadone results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Methadone results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CX3CL1 protein CTD PMID:20178837 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Methadone results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Methadone affects the localization of CYCS protein CTD PMID:20691259 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions
affects metabolic processing
ISO Aminoglutethimide inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone]; formestane inhibits the reaction [CYP19A1 protein affects the metabolism of Methadone] CTD PMID:15242824 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:63,449,148...63,476,917
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
decreases activity
ISO CYP2D22 protein results in increased metabolism of Methadone
Methadone results in decreased activity of CYP2D6 protein
CTD PMID:16595712 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
ISO CYP3A4 protein affects the metabolism of Methadone
CYP3A4 protein results in increased metabolism of Methadone
CTD PMID:15986265 PMID:16595712 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA] CTD PMID:18990547 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Hcrt hypocretin neuropeptide precursor multiple interactions EXP Methadone affects the reaction [Cocaine affects the expression of HCRT mRNA] CTD PMID:18990547 NCBI chr10:86,190,289...86,191,524
Ensembl chr10:86,189,775...86,191,524
JBrowse link
G Il10 interleukin 10 increases secretion EXP Methadone results in increased secretion of IL10 protein CTD PMID:20178837 NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
JBrowse link
G Il1a interleukin 1 alpha increases expression EXP Methadone results in increased expression of IL1A protein CTD PMID:20178837 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta increases secretion
increases expression
EXP Methadone results in increased secretion of IL1B protein
Methadone results in increased expression of IL1B protein
CTD PMID:20178837 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il2 interleukin 2 decreases expression ISO Methadone results in decreased expression of IL2 mRNA CTD PMID:23965172 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il4 interleukin 4 increases expression
multiple interactions
ISO Methadone results in increased expression of IL4 mRNA; Methadone results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Methadone results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Methadone results in increased expression of IL4 mRNA]
CTD PMID:23965172 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il6 interleukin 6 increases expression
increases secretion
EXP Methadone results in increased expression of IL6 mRNA; Methadone results in increased expression of IL6 protein
Methadone results in increased secretion of IL6 protein
CTD PMID:20178837 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ins2 insulin 2 decreases response to substance ISO Methadone results in decreased susceptibility to INS protein CTD PMID:2554359 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Chlorobutanol promotes the reaction [Methadone results in decreased activity of KCNH2 protein] CTD PMID:14527710 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
G Lep leptin increases expression ISO Methadone results in increased expression of LEP protein CTD PMID:15717844 NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK1 protein CTD PMID:23965172 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Methadone results in increased phosphorylation of MAPK3 protein CTD PMID:23965172 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Nfkbia NFKB inhibitor alpha increases expression ISO Methadone results in increased expression of NFKBIA protein CTD PMID:22258905 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Methadone binds to OPRD1 protein
[Methadone binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP Methadone binds to OPRK1 protein
[Methadone binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRK1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Methadone binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Methadone binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Pld2 phospholipase D2 increases activity ISO Methadone results in increased activity of PLD2 protein CTD PMID:23965172 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,754,988...55,771,435
JBrowse link
G Prl prolactin affects secretion
increases secretion
increases expression
ISO Methadone affects the secretion of PRL protein
Methadone results in increased secretion of PRL protein
Methadone results in increased expression of PRL protein
CTD PMID:2554359 PMID:16675813 PMID:21094671 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Tlr4 toll-like receptor 4 affects binding
increases expression
affects response to substance
multiple interactions
ISO
EXP
Methadone binds to TLR4 protein
Methadone results in increased expression of TLR4 mRNA; Methadone results in increased expression of TLR4 protein
Methadone affects the susceptibility to TLR4 protein
Naloxone affects the reaction [Methadone binds to TLR4 protein]
CTD PMID:20178837 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor increases secretion
increases expression
EXP Methadone results in increased secretion of TNF protein
Methadone results in increased expression of TNF protein
CTD PMID:20178837 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
morphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects metabolic processing
multiple interactions
ISO
EXP
ABCB1 affects the metabolism of Morphine
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA
CTD PMID:23748253 PMID:26554626 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Abtb3 ankyrin repeat and BTB domain containing 3 decreases expression ISO Morphine results in decreased expression of ABTB3 mRNA CTD PMID:21955143 NCBI chr 7:19,922,883...20,199,740
Ensembl chr 7:19,923,814...20,198,110
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression
multiple interactions
EXP Morphine results in decreased expression of ACAT1 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of ACAT1 protein]
CTD PMID:23056601 NCBI chr 8:62,876,003...62,905,080
Ensembl chr 8:62,876,003...62,905,042
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases chemical synthesis
ISO [ACHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
ACHE protein results in increased chemical synthesis of Morphine
CTD PMID:30080993 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410
JBrowse link
G Adcy1 adenylate cyclase 1 multiple interactions ISO [ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine CTD PMID:16914643 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:86,124,850...86,261,075
JBrowse link
G Adcy6 adenylate cyclase 6 affects expression EXP Morphine affects the expression of ADCY6 mRNA CTD PMID:15829634 NCBI chr 7:131,621,860...131,642,923
Ensembl chr 7:131,621,860...131,642,770
JBrowse link
G Adcy8 adenylate cyclase 8 affects response to substance
affects expression
multiple interactions
ISO
EXP
ADCY8 protein affects the susceptibility to Morphine
Morphine affects the expression of ADCY8 mRNA
[ADCY8 protein co-treated with ADCY1 protein] affects the susceptibility to Morphine
CTD PMID:15829634 PMID:16914643 NCBI chr 7:98,306,434...98,555,687
Ensembl chr 7:98,306,464...98,555,038
JBrowse link
G Adgra1 adhesion G protein-coupled receptor A1 decreases expression ISO Morphine results in decreased expression of ADGRA1 mRNA CTD PMID:21955143 NCBI chr 1:194,629,744...194,673,254
Ensembl chr 1:204,059,367...204,102,869
JBrowse link
G Adora1 adenosine A1 receptor affects response to substance
increases expression
multiple interactions
ISO
EXP
ADORA1 protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA1 mRNA; Morphine results in increased expression of ADORA1 protein
[lead acetate co-treated with Morphine] results in increased expression of ADORA1 mRNA; [lead acetate co-treated with Morphine] results in increased expression of ADORA1 protein
CTD PMID:9407998 PMID:26478469 NCBI chr13:48,210,922...48,247,826
Ensembl chr13:48,213,273...48,247,190
JBrowse link
G Adora2a adenosine A2a receptor affects response to substance
increases expression
ISO ADORA2A protein affects the susceptibility to Morphine
Morphine results in increased expression of ADORA2A mRNA
CTD PMID:14756803 PMID:21955143 NCBI chr20:13,315,270...13,332,802
Ensembl chr20:13,315,270...13,332,802
JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression EXP morphine increases expression of Adra2a mRNA in cerebral cortex RGD PMID:9105684 RGD:401976538 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871
JBrowse link
G Agrp agouti related neuropeptide increases expression ISO Morphine results in increased expression of AGRP mRNA CTD PMID:20144693 NCBI chr19:33,447,992...33,481,602
Ensembl chr19:50,357,905...50,358,698
JBrowse link
G Aif1 allograft inflammatory factor 1 multiple interactions
increases expression
EXP
ISO
[lead acetate co-treated with Morphine] results in increased expression of AIF1 mRNA
corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of AIF1 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]
CTD PMID:26478469 PMID:37394652 NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,652,243...3,657,339
JBrowse link
G Ak5 adenylate kinase 5 decreases expression ISO Morphine results in decreased expression of AK5 mRNA CTD PMID:21955143 NCBI chr 2:244,057,240...244,241,372
Ensembl chr 2:244,057,240...244,241,366
JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B1 decreases expression EXP Morphine results in decreased expression of AKR1B1 protein CTD PMID:23056601 NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:63,899,222...63,913,315
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
decreases expression
ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]
Morphine results in increased expression of AKT1 protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form]
CTD PMID:19239323 PMID:20600172 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Alb albumin multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of ALB protein] CTD PMID:23056601 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
JBrowse link
G Ano3 anoctamin 3 increases expression ISO Morphine results in increased expression of ANO3 mRNA CTD PMID:21955143 NCBI chr 3:97,235,671...97,550,090
Ensembl chr 3:117,692,103...118,004,675
JBrowse link
G Anxa6 annexin A6 decreases expression EXP Morphine results in decreased expression of ANXA6 protein CTD PMID:23056601 NCBI chr10:39,602,106...39,657,183
Ensembl chr10:39,602,106...39,657,359
JBrowse link
G Apoa1 apolipoprotein A1 increases expression EXP Morphine results in increased expression of APOA1 protein CTD PMID:23056601 NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:55,423,825...55,425,729
JBrowse link
G Apob apolipoprotein B increases expression ISO Morphine results in increased expression of APOB protein CTD PMID:18980684 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814
JBrowse link
G Apoe apolipoprotein E increases expression
multiple interactions
EXP Morphine results in increased expression of APOE protein
Morphine deficiency affects the reaction [Morphine results in increased expression of APOE protein]
CTD PMID:23056601 NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:88,481,385...88,485,855
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO Morphine results in increased expression of AQP1 mRNA CTD PMID:21178816 NCBI chr 4:85,812,784...85,824,964
Ensembl chr 4:85,812,784...85,830,504
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression EXP Morphine results in increased expression of AQP3 mRNA; Morphine results in increased expression of AQP3 protein CTD PMID:25766885 NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:61,035,166...61,040,685
JBrowse link
G Aqp4 aquaporin 4 decreases expression
decreases expression
ISO
EXP
Morphine results in decreased expression of AQP4 mRNA
morphine decreases expression of AQP4 protein in cultured astrocytes
CTD
RGD
PMID:21955143 PMID:28341892 RGD:597978120 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP
IEP
morphine increases expression in Arc protein in nucleus accumbens
morphine increases expression of Arc mRNA in prefrontal cortex
morphine co-treated with naloxone increases expression of Arc protein in brain
Morphine increases expression of Arc protein in shell of nucleus accumbens
RGD PMID:21549764 PMID:30550948 PMID:19262551 PMID:25746394 RGD:401851922, RGD:401959617, RGD:401938601, RGD:11087075 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220
JBrowse link
G Arl4d ARF like GTPase 4D increases expression ISO Morphine results in increased expression of ARL4D mRNA CTD PMID:20144693 NCBI chr10:87,092,276...87,103,079
Ensembl chr10:87,077,523...87,106,199
JBrowse link
G Arl6ip5 ARF like GTPase 6 interacting protein 5 multiple interactions
increases expression
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine results in increased expression of ARL6IP5 protein
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
CTD PMID:21600884 NCBI chr 4:129,810,650...129,838,628
Ensembl chr 4:131,367,289...131,400,130
JBrowse link
G Arpp21 cAMP regulated phosphoprotein 21 increases expression
decreases expression
ISO Morphine results in increased expression of ARPP21 mRNA
Morphine deficiency results in decreased expression of ARPP21 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 8:112,034,636...112,199,273
Ensembl chr 8:120,912,970...121,031,357
JBrowse link
G Arrb2 arrestin, beta 2 affects response to substance
multiple interactions
ISO
EXP
ARRB2 gene SNP affects the susceptibility to Morphine
[Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein
ARRB2 protein affects the susceptibility to Morphine
[gp120 protein, Human immunodeficiency virus 1 co-treated with Morphine] results in decreased expression of ARRB2 mRNA; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of AKT1 protein modified form]; ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
CTD PMID:16103897 PMID:19239323 PMID:19477204 PMID:23300227 PMID:24063433 More... NCBI chr10:55,645,539...55,653,485
Ensembl chr10:55,645,357...55,653,487
JBrowse link
G Art3 ADP-ribosyltransferase 3 multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of ART3 protein] CTD PMID:23056601 NCBI chr14:15,921,540...16,003,764
Ensembl chr14:15,921,395...15,949,806
JBrowse link
G Asic4 acid sensing ion channel subunit family member 4 increases expression ISO Morphine results in increased expression of ASIC4 mRNA CTD PMID:21178816 NCBI chr 9:84,389,610...84,411,545
Ensembl chr 9:84,390,104...84,411,538
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases expression
ISO corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]] CTD PMID:37394652 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase decreases expression EXP Morphine results in decreased expression of ATIC protein CTD PMID:23056601 NCBI chr 9:80,614,311...80,634,360
Ensembl chr 9:80,614,283...80,635,756
JBrowse link
G Atrx ATRX, chromatin remodeler increases expression ISO Morphine results in increased expression of ATRX mRNA CTD PMID:21955143 NCBI chr  X:74,916,548...75,062,880
Ensembl chr  X:74,916,548...75,062,880
JBrowse link
G Avp arginine vasopressin increases expression ISO Morphine increases expression of Avp mRNA in the dorsal striatum RGD PMID:29772497 RGD:408418735 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO Morphine results in decreased expression of AVPR1A mRNA CTD PMID:21178816 NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:59,999,738...60,003,837
JBrowse link
G Bag3 BAG cochaperone 3 increases expression EXP Morphine results in increased expression of BAG3 protein CTD PMID:23056601 NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:192,475,828...192,557,280
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO Morphine results in increased expression of BAK1 protein CTD PMID:19070643 NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,102,335...5,110,974
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
decreases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]; Morphine inhibits the reaction [Doxorubicin results in increased expression of BAX protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
Morphine results in increased expression of BAX mRNA; Morphine results in increased expression of BAX protein
Morphine results in decreased expression of BAX mRNA
epigallocatechin gallate inhibits the reaction [Morphine results in increased expression of BAX protein]; Lithium inhibits the reaction [Morphine results in increased expression of BAX mRNA]
TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein]
CTD PMID:10534122 PMID:10809959 PMID:12196588 PMID:12702572 PMID:12927789 More... NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Morphine results in increased expression of BBC3 mRNA CTD PMID:19397953 NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:86,141,603...86,150,666
JBrowse link
G Bcas1 brain enriched myelin associated protein 1 decreases expression ISO Morphine results in decreased expression of BCAS1 mRNA CTD PMID:21955143 NCBI chr 3:159,136,077...159,219,072
Ensembl chr 3:179,551,704...179,637,743
JBrowse link
G Bche butyrylcholinesterase increases chemical synthesis
multiple interactions
ISO BCHE protein results in increased chemical synthesis of Morphine
[BCHE protein results in increased degradation of 6-O-monoacetylmorphine] which results in increased chemical synthesis of Morphine
CTD PMID:30080993 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
G Bcl11b BCL11 transcription factor B increases expression
decreases expression
ISO Morphine results in increased expression of BCL11B mRNA
Morphine deficiency results in decreased expression of BCL11B mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 6:132,598,968...132,692,123
Ensembl chr 6:132,598,968...132,691,301
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]; Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]; Morphine inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]; PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]
Morphine results in decreased expression of BCL2 mRNA; Morphine results in decreased expression of BCL2 protein
epigallocatechin gallate inhibits the reaction [Morphine results in decreased expression of BCL2 protein]; Lithium inhibits the reaction [Morphine results in decreased expression of BCL2 mRNA]
CTD PMID:10534122 PMID:12196588 PMID:12927789 PMID:17542780 PMID:18976035 More... NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression EXP Morphine results in decreased expression of BCL2L1 mRNA CTD PMID:15183518 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907
JBrowse link
G Bcl2l11 Bcl2-like 11 increases expression ISO Morphine results in increased expression of BCL2L11 protein CTD PMID:19292871 NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:135,817,562...135,960,695
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression
increases expression
decreases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of BDNF mRNA; Morphine results in increased expression of BDNF protein
Morphine increases expression of Bdnf mRNA in ventral tegmental area
Morphine results in decreased expression of BDNF mRNA; Morphine results in decreased expression of BDNF mRNA alternative form
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]; Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]; Morphine promotes the reaction [ING2 protein binds to BDNF promoter]; Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]; Morphine promotes the reaction [SIN3A protein binds to BDNF promoter]; Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]
AM 251 inhibits the reaction [Morphine results in increased expression of BDNF protein]; BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]; Curcumin inhibits the reaction [Morphine results in increased expression of BDNF mRNA]
CTD
RGD
PMID:19033880 PMID:25643298 PMID:27461790 PMID:30550948 RGD:401959617 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression
ISO Morphine inhibits the reaction [BECN1 protein binds to BCL2 protein]
Morphine results in increased expression of BECN1 protein
CTD PMID:20190558 NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
JBrowse link
G Bex4 brain expressed, X-linked 4 increases expression ISO Morphine results in increased expression of BEX4 mRNA CTD PMID:21178816 NCBI chr  X:103,923,609...103,925,041
Ensembl chr  X:103,923,338...103,925,496
JBrowse link
G Bok BCL2 family apoptosis regulator BOK decreases expression ISO Morphine results in decreased expression of BOK mRNA CTD PMID:21955143 NCBI chr 9:101,670,729...101,681,834
Ensembl chr 9:101,670,625...101,681,833
JBrowse link
G C1ql3 complement C1q like 3 increases expression ISO Morphine results in increased expression of C1QL3 mRNA CTD PMID:21178816 NCBI chr17:76,119,344...76,129,170
Ensembl chr17:81,028,418...81,038,244
JBrowse link
G Calb1 calbindin 1 increases expression ISO Morphine results in increased expression of CALB1 mRNA CTD PMID:21178816 NCBI chr 5:34,172,612...34,199,555
Ensembl chr 5:34,172,664...34,200,160
JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression
multiple interactions
EXP
ISO
Morphine results in increased expression of CALCA mRNA; Morphine results in increased expression of CALCA protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]
GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]
CTD PMID:16935424 PMID:20359526 PMID:20568289 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha affects response to substance
increases expression
ISO CAMK2A protein affects the susceptibility to Morphine
Morphine results in increased expression of CAMK2A mRNA
CTD PMID:20053885 PMID:21955143 NCBI chr18:56,648,779...56,711,505
Ensembl chr18:56,649,025...56,711,504
JBrowse link
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 decreases expression ISO Morphine results in decreased expression of CAP1 mRNA CTD PMID:21955143 NCBI chr 5:140,427,265...140,507,678
Ensembl chr 5:140,427,269...140,453,470
JBrowse link
G Car2 carbonic anhydrase 2 increases expression ISO Morphine results in increased expression of CAR2 mRNA CTD PMID:20144693 NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:88,462,872...88,478,064
JBrowse link
G Carhsp1 calcium regulated heat stable protein 1 increases expression ISO Morphine results in increased expression of CARHSP1 mRNA CTD PMID:21178816 NCBI chr10:6,946,036...6,960,556
Ensembl chr10:7,452,978...7,467,770
JBrowse link
G Cartpt CART prepropeptide increases expression ISO Morphine results in increased expression of CARTPT mRNA CTD PMID:20144693 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712
JBrowse link
G Casp1 caspase 1 decreases expression EXP Morphine results in decreased expression of CASP1 mRNA CTD PMID:15183518 NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:10,746,333...10,882,275
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases activity
increases expression
ISO
EXP
[[Morphine results in increased expression of BAX protein] co-treated with [Morphine results in decreased expression of BCL2 protein]] results in increased activity of CASP3 protein; Morphine inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Morphine results in increased activity of and results in increased cleavage of CASP3 protein; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]
Morphine results in increased cleavage of CASP3 protein
Morphine results in increased expression of CASP3 protein
epigallocatechin gallate inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased activity of CASP3 protein]
corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Minocycline inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form]; SB 203580 inhibits the reaction [Morphine results in increased activity of CASP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]
Morphine results in increased expression of CASP3 protein; Morphine results in increased expression of CASP3 protein alternative form
CTD PMID:10534122 PMID:11590188 PMID:12196588 PMID:16102899 PMID:17542780 More... NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
decreases expression
ISO ARRB2 protein inhibits the reaction [Morphine results in decreased expression of CASP8 protein alternative form]
Morphine results in increased activity of CASP8 protein
CTD PMID:11590188 PMID:19070643 PMID:19239323 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
ISO
EXP
Morphine results in increased activity of CASP9 protein
Morphine results in increased expression of CASP9 mRNA
CTD PMID:15183518 PMID:19292871 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [Morphine results in increased abundance of Hydrogen Peroxide] CTD PMID:14871405 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cbln1 cerebellin 1 precursor decreases expression ISO Morphine results in decreased expression of CBLN1 mRNA CTD PMID:21955143 NCBI chr19:19,608,763...19,612,572
Ensembl chr19:35,781,952...35,785,960
JBrowse link
G Ccdc136 coiled-coil domain containing 136 decreases expression ISO Morphine results in decreased expression of CCDC136 mRNA CTD PMID:21955143 NCBI chr 4:58,963,196...58,992,962
Ensembl chr 4:58,962,908...58,992,975
JBrowse link
G Cck cholecystokinin decreases expression ISO Morphine results in decreased expression of CCK mRNA CTD PMID:21955143 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686
JBrowse link
G Cckbr cholecystokinin B receptor affects response to substance ISO CCKBR protein affects the susceptibility to Morphine CTD PMID:11403953 PMID:11880531 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:169,183,194...169,193,745
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion EXP Morphine results in increased secretion of CCL2 protein CTD PMID:20178837 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases secretion EXP Morphine results in increased secretion of CCL3 protein CTD PMID:20178837 NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,948,889...68,950,439
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO beta-funaltrexamine inhibits the reaction [Morphine results in decreased expression of CCL5 protein]; Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Cd38 CD38 molecule affects response to substance ISO CD38 affects the susceptibility to Morphine CTD PMID:20551293 NCBI chr14:71,384,532...71,424,794
Ensembl chr14:71,384,532...71,424,505
JBrowse link
G Cd79b CD79b molecule increases expression ISO Morphine results in increased expression of CD79B mRNA CTD PMID:20144693 NCBI chr10:91,739,134...91,742,312
Ensembl chr10:91,739,137...91,742,405
JBrowse link
G Cd9 CD9 molecule increases expression EXP Morphine results in increased expression of CD9 protein CTD PMID:23056601 NCBI chr 4:159,942,553...159,975,463
Ensembl chr 4:159,942,560...159,975,444
JBrowse link
G Cdh22 cadherin 22 increases expression ISO Morphine results in increased expression of CDH22 mRNA CTD PMID:21178816 NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:174,264,869...174,390,142
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein CTD PMID:12702572 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Cep83 centrosomal protein 83 increases expression ISO Morphine results in increased expression of CEP83 mRNA CTD PMID:20144693 NCBI chr 7:29,280,358...29,389,574
Ensembl chr 7:31,167,216...31,276,716
JBrowse link
G Ces2h carboxylesterase 2H increases chemical synthesis
multiple interactions
ISO CES2 protein results in increased chemical synthesis of Morphine
Cocaine inhibits the reaction [CES2 protein results in increased chemical synthesis of Morphine]
CTD PMID:8930175 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 affects response to substance ISO CHRM5 protein affects the susceptibility to Morphine CTD PMID:12154229 NCBI chr 3:119,739,229...119,791,630
Ensembl chr 3:119,735,975...119,792,166
JBrowse link
G Cirbp cold inducible RNA binding protein increases expression ISO Morphine results in increased expression of CIRBP mRNA CTD PMID:21955143 NCBI chr 7:10,184,515...10,189,623 JBrowse link
G Cldn2 claudin 2 increases expression ISO Morphine results in increased expression of CLDN2 mRNA CTD PMID:21178816 NCBI chr  X:108,248,383...108,258,847
Ensembl chr  X:108,237,676...108,262,377
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Morphine results in decreased expression of CMBL protein CTD PMID:23056601 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:84,242,512...84,301,880
JBrowse link
G Cmtm5 CKLF-like MARVEL transmembrane domain containing 5 increases expression ISO Morphine results in increased expression of CMTM5 mRNA CTD PMID:21955143 NCBI chr15:28,412,624...28,415,304
Ensembl chr15:32,382,608...32,385,271
JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of CNBP protein] CTD PMID:23056601 NCBI chr 4:121,860,102...121,868,976
Ensembl chr 4:121,860,105...121,869,010
JBrowse link
G Cnr1 cannabinoid receptor 1 multiple interactions
decreases expression
increases expression
EXP
ISO
[Morphine results in increased expression of CNR1 mRNA] which results in increased susceptibility to Dronabinol; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
Morphine deficiency results in decreased expression of CNR1 mRNA
CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]
CTD PMID:9351646 PMID:21955143 PMID:22258905 PMID:27126842 NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:53,204,260...53,239,252
JBrowse link
G Comt catechol-O-methyltransferase affects response to substance
multiple interactions
ISO COMT protein affects the susceptibility to Morphine
[COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine
CTD PMID:18834357 PMID:21127283 NCBI chr11:96,072,371...96,091,956
Ensembl chr11:96,072,489...96,092,533
JBrowse link
G Coq9 coenzyme Q9 decreases expression EXP Morphine results in decreased expression of COQ9 protein CTD PMID:23056601 NCBI chr19:10,172,943...10,185,960
Ensembl chr19:10,172,949...10,185,937
JBrowse link
G Cpe carboxypeptidase E increases expression ISO Morphine results in increased expression of CPE mRNA CTD PMID:20144693 NCBI chr16:29,796,707...29,908,647
Ensembl chr16:29,796,689...29,909,524
JBrowse link
G Creb1 cAMP responsive element binding protein 1 decreases expression
decreases phosphorylation
increases phosphorylation
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of CREB1 mRNA
morphine decreases phosphorylation of Creb1 protein in prefrontal cortex
morphine increases phosphorylation of Creb protein in Cortical cell
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of CREB1 protein]; suvorexant inhibits the reaction [Morphine results in increased expression of CREB1 protein]
Morphine inhibits the reaction [CREB1 protein modified form binds to BDNF promoter]; Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine promotes the reaction [CREB1 protein binds to BDNF promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]
Morphine results in decreased phosphorylation of CREB1 protein
CTD
RGD
PMID:14750654 PMID:15183518 PMID:16598705 PMID:23292329 PMID:25643298 More... RGD:401901600, RGD:401901284 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Crem cAMP responsive element modulator increases expression ISO Morphine results in increased expression of CREM mRNA CTD PMID:22454534 NCBI chr17:58,932,011...59,001,160
Ensembl chr17:58,934,147...59,001,160
JBrowse link
G Crh corticotropin releasing hormone increases expression ISO Morphine deficiency results in increased expression of CRH mRNA; Morphine results in increased expression of CRH mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Morphine deficiency
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25582704 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466
JBrowse link
G Crp C-reactive protein increases expression ISO Morphine results in increased expression of CRP protein CTD PMID:18980684 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514
JBrowse link
G Cryab crystallin, alpha B decreases expression
increases expression
ISO
EXP
Morphine results in decreased expression of CRYAB mRNA
Morphine results in increased expression of CRYAB protein
CTD PMID:21955143 PMID:23056601 NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:59,989,814...59,995,528
JBrowse link
G Csdc2 cold shock domain containing C2 decreases expression ISO Morphine results in decreased expression of CSDC2 mRNA CTD PMID:21955143 NCBI chr 7:113,451,998...113,466,464
Ensembl chr 7:115,332,128...115,346,596
JBrowse link
G Cstb cystatin B decreases expression EXP Morphine results in decreased expression of CSTB protein CTD PMID:23056601 NCBI chr20:10,245,462...10,247,505
Ensembl chr20:10,245,158...10,247,199
JBrowse link
G Ctnnal1 catenin alpha-like 1 increases expression ISO Morphine results in increased expression of CTNNAL1 mRNA CTD PMID:21178816 NCBI chr 5:76,309,546...76,375,869
Ensembl chr 5:76,309,546...76,364,637
JBrowse link
G Ctsb cathepsin B increases expression EXP Morphine results in increased expression of CTSB mRNA CTD PMID:9429908 NCBI chr15:41,565,607...41,586,479
Ensembl chr15:41,565,611...41,586,478
JBrowse link
G Cux2 cut-like homeobox 2 increases expression ISO Morphine results in increased expression of CUX2 mRNA CTD PMID:21178816 NCBI chr12:40,168,402...40,368,303
Ensembl chr12:40,149,292...40,366,528
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 affects response to substance
increases secretion
EXP CX3CL1 protein affects the susceptibility to Morphine
Morphine results in increased secretion of CX3CL1 protein
CTD PMID:15317861 PMID:20178837 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases secretion EXP Morphine results in increased secretion of CXCL1 protein CTD PMID:20178837 NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,477,549...17,479,811
JBrowse link
G Cxxc1 CXXC finger protein 1 affects expression ISO Morphine affects the expression of CXXC1 mRNA CTD PMID:33891991 NCBI chr18:70,088,407...70,093,786
Ensembl chr18:70,088,460...70,093,778
JBrowse link
G Cybb cytochrome b-245 beta chain increases expression
multiple interactions
ISO Morphine results in increased expression of CYBB protein
Saquinavir inhibits the reaction [Morphine results in increased expression of CYBB protein]
CTD PMID:14871405 NCBI chr  X:16,030,596...16,065,065
Ensembl chr  X:16,030,596...16,065,065
JBrowse link
G Cycs cytochrome c, somatic increases secretion
decreases secretion
multiple interactions
ISO
EXP
Morphine results in increased secretion of CYCS protein
Morphine results in decreased secretion of CYCS protein
Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein]
CTD PMID:15345483 PMID:17542780 PMID:19292871 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Morphine results in decreased activity of CYP1A2 protein CTD PMID:35914676 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Morphine results in increased expression of CYP27A1 mRNA CTD PMID:20144693 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases activity ISO Morphine results in increased activity of CYP2B6 protein CTD PMID:35914676 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects chemical synthesis
increases activity
multiple interactions
ISO CYP2D6 protein affects the chemical synthesis of Morphine
Morphine results in increased activity of CYP2D6 protein
[CYP2D6 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of Morphine
CTD PMID:15625333 PMID:16595712 PMID:21241245 PMID:35914676 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Dbi diazepam binding inhibitor increases expression EXP morphine increases expression of Dbi mRNA in brain RGD PMID:15950760 RGD:408361840 NCBI chr13:33,794,231...33,802,632
Ensembl chr13:33,759,845...33,821,450
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DCXR protein] CTD PMID:23056601 NCBI chr10:106,504,730...106,506,619 JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein]]; Morphine deficiency affects the reaction [Morphine results in increased expression of DDAH2 protein] CTD PMID:23056601 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,766,120...3,769,183
JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression
multiple interactions
ISO Morphine results in increased expression of DDB2 mRNA
Naloxone inhibits the reaction [Morphine results in increased expression of DDB2]
CTD PMID:19397953 NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:97,640,579...97,664,066
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]] CTD PMID:37394652 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase decreases expression ISO Morphine results in decreased expression of DHCR24 mRNA CTD PMID:21955143 NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:126,573,338...126,599,936
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B increases expression ISO Morphine results in increased expression of DHRS7B mRNA CTD PMID:21178816 NCBI chr10:45,504,344...45,537,094
Ensembl chr10:46,003,845...46,036,499
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 decreases expression
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of DLG4 mRNA; Morphine results in decreased expression of DLG4 protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]
Morphine results in increased expression of DLG4 mRNA
CTD PMID:15183518 PMID:16598705 PMID:21955143 PMID:22713680 NCBI chr10:55,239,397...55,267,780
Ensembl chr10:55,236,869...55,265,839
JBrowse link
G Dlx5 distal-less homeobox 5 increases expression ISO Morphine results in increased expression of DLX5 mRNA CTD PMID:21178816 NCBI chr 4:34,999,139...35,003,504
Ensembl chr 4:35,965,579...35,969,845
JBrowse link
G Dnah3 dynein, axonemal, heavy chain 3 decreases expression ISO Morphine results in decreased expression of DNAH3 mRNA CTD PMID:21178816 NCBI chr 1:174,305,929...174,479,490
Ensembl chr 1:183,738,013...183,910,432
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO Morphine results in increased expression of DNMT1 mRNA CTD PMID:33891991 NCBI chr 8:27,716,797...27,763,405
Ensembl chr 8:27,716,797...27,763,119
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha affects expression ISO Morphine affects the expression of DNMT3A mRNA CTD PMID:33891991 NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:32,512,070...32,614,970
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta affects expression ISO Morphine affects the expression of DNMT3B mRNA CTD PMID:33891991 NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:162,604,037...162,629,313
JBrowse link
G Dock10 dedicator of cytokinesis 10 increases expression ISO Morphine results in increased expression of DOCK10 mRNA CTD PMID:21178816 NCBI chr 9:81,843,599...82,101,540
Ensembl chr 9:89,291,800...89,549,973
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of DPYSL2 protein] CTD PMID:23056601 NCBI chr15:45,181,041...45,287,065
Ensembl chr15:45,181,041...45,287,065
JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 multiple interactions
decreases expression
EXP Morphine deficiency promotes the reaction [Morphine results in decreased expression of DPYSL3 protein] CTD PMID:23056601 NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,625,357...35,731,152
JBrowse link
G Drd1 dopamine receptor D1 increases expression
decreases expression
ISO Morphine results in increased expression of DRD1 mRNA
Morphine deficiency results in decreased expression of DRD1 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166
JBrowse link
G Drd2 dopamine receptor D2 decreases expression
multiple interactions
affects response to substance
increases expression
EXP
ISO
Morphine results in decreased expression of DRD2 mRNA
Morphine deficiency results in decreased expression of DRD2 mRNA
[lead acetate co-treated with Morphine] results in increased expression of DRD2 mRNA; [lead acetate co-treated with Morphine] results in increased expression of DRD2 protein
DRD2 protein affects the susceptibility to Morphine
Morphine results in increased expression of DRD2 mRNA
CTD PMID:2571179 PMID:15183518 PMID:17063042 PMID:23702354 PMID:27126842 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Drd4 dopamine receptor D4 increases expression EXP Morphine results in increased expression of DRD4 mRNA CTD PMID:15183518 NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:205,826,049...205,830,458
JBrowse link
G Dscaml1 DS cell adhesion molecule-like 1 increases expression ISO Morphine results in increased expression of DSCAML1 mRNA CTD PMID:20144693 NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:54,636,932...54,954,040
JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression ISO Morphine deficiency results in increased expression of DUSP6 mRNA; Morphine results in increased expression of DUSP6 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:35,977,921...35,983,833
JBrowse link
G Dync1h1 dynein cytoplasmic 1 heavy chain 1 decreases expression ISO Morphine results in decreased expression of DYNC1H1 mRNA CTD PMID:21178816 NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:135,430,750...135,502,116
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP Morphine results in decreased expression of ECH1 protein CTD PMID:23056601 NCBI chr 1:93,241,076...93,248,314
Ensembl chr 1:93,241,734...93,248,440
JBrowse link
G Eed embryonic ectoderm development increases expression ISO Morphine results in increased expression of EED mRNA CTD PMID:33891991 NCBI chr 1:153,280,419...153,307,537
Ensembl chr 1:153,280,422...153,307,500
JBrowse link
G Efhd1 EF-hand domain family, member D1 decreases expression ISO Morphine results in decreased expression of EFHD1 mRNA CTD PMID:21955143 NCBI chr 9:95,386,155...95,432,800
Ensembl chr 9:95,386,169...95,432,798
JBrowse link
G Egr1 early growth response 1 increases expression
increases expression
ISO
EXP
Morphine deficiency results in increased expression of EGR1 mRNA; Morphine results in increased expression of EGR1 mRNA
Morphine increases expression of Egr1 mRNA in ventral tegmental area and prefrontal cortex
CTD
RGD
PMID:21955143 PMID:27126842 PMID:30550948 RGD:401959617 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
JBrowse link
G Egr2 early growth response 2 increases expression ISO Morphine results in increased expression of EGR2 mRNA CTD PMID:22454534 NCBI chr20:21,050,149...21,055,201
Ensembl chr20:21,050,149...21,057,748
JBrowse link
G Egr3 early growth response 3 increases expression ISO Morphine results in increased expression of EGR3 mRNA CTD PMID:21955143 NCBI chr15:51,560,482...51,565,778
Ensembl chr15:51,560,344...51,565,712
JBrowse link
G Egr4 early growth response 4 multiple interactions
increases expression
affects response to substance
ISO
EXP
2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA]; [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
EGR4 protein affects the susceptibility to Morphine
CTD PMID:22454534 NCBI chr 4:119,605,358...119,607,817
Ensembl chr 4:119,605,357...119,608,368
JBrowse link
G Ehd1 EH-domain containing 1 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of EHD1 protein] CTD PMID:23056601 NCBI chr 1:213,009,113...213,031,488
Ensembl chr 1:213,008,049...213,031,485
JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 affects expression ISO Morphine affects the expression of EHMT1 mRNA CTD PMID:33891991 NCBI chr 3:27,978,888...28,127,178
Ensembl chr 3:27,978,888...28,127,349
JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 affects expression ISO Morphine affects the expression of EHMT2 mRNA CTD PMID:33891991 NCBI chr20:3,924,263...3,941,238
Ensembl chr20:3,924,263...3,941,384
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation
ISO corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]] CTD PMID:37394652 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Eif5a eukaryotic translation initiation factor 5A increases expression ISO Morphine results in increased expression of EIF5A mRNA CTD PMID:19397953 NCBI chr10:55,138,821...55,143,272
Ensembl chr10:55,138,823...55,143,330
JBrowse link
G Elk1 ETS transcription factor ELK1 affects response to substance
increases activity
multiple interactions
ISO ELK1 protein affects the susceptibility to Morphine
Morphine results in increased activity of ELK1 protein
[Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA
CTD PMID:22454534 NCBI chr  X:3,692,367...3,709,252
Ensembl chr  X:3,693,293...3,709,249
JBrowse link
G Eml2 EMAP like 2 increases expression EXP Morphine results in increased expression of EML2 protein CTD PMID:23056601 NCBI chr 1:78,827,595...78,859,342
Ensembl chr 1:87,955,606...87,987,366
JBrowse link
G Enpp3 ectonucleotide pyrophosphatase/phosphodiesterase 3 increases expression EXP Morphine results in increased expression of ENPP3 protein CTD PMID:23056601 NCBI chr 1:22,382,717...22,454,324
Ensembl chr 1:22,382,964...22,454,314
JBrowse link
G Ephx2 epoxide hydrolase 2 increases expression ISO Morphine results in increased expression of EPHX2 mRNA CTD PMID:21178816 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160
JBrowse link
G Erp44 endoplasmic reticulum protein 44 increases expression ISO Morphine results in increased expression of ERP44 mRNA CTD PMID:21178816 NCBI chr 5:62,516,550...62,610,762
Ensembl chr 5:67,312,098...67,406,444
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions
affects expression
EXP
ISO
Morphine promotes the reaction [EZH2 protein binds to BDNF promoter]
Morphine affects the expression of EZH2 mRNA
CTD PMID:25643298 PMID:33891991 NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:77,624,223...77,687,183
JBrowse link
G F2 coagulation factor II, thrombin increases expression
multiple interactions
EXP Morphine results in increased expression of F2 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of F2 protein]
CTD PMID:23056601 NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:98,051,960...98,065,246
JBrowse link
G F7 coagulation factor VII increases expression ISO Morphine results in increased expression of F7 protein CTD PMID:18980684 NCBI chr16:83,191,896...83,202,775
Ensembl chr16:83,191,914...83,202,738
JBrowse link
G Fam107a family with sequence similarity 107, member A increases expression ISO Morphine results in increased expression of FAM107A mRNA CTD PMID:21955143 NCBI chr15:19,038,726...19,060,644
Ensembl chr15:19,038,616...19,065,219
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
[Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein
Morphine results in increased expression of FAS mRNA
CTD PMID:12702572 PMID:16210602 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:241,205,935...241,246,104
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of FASL mRNA
CTD PMID:16210602 NCBI chr13:76,680,885...76,706,042
Ensembl chr13:76,688,243...76,695,503
JBrowse link
G Fblim1 filamin binding LIM protein 1 increases expression
multiple interactions
EXP Morphine results in increased expression of FBLIM1 protein
Morphine deficiency affects the reaction [Morphine results in increased expression of FBLIM1 protein]
CTD PMID:23056601 NCBI chr 5:159,167,004...159,198,578
Ensembl chr 5:159,167,004...159,196,853
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO Morphine results in decreased expression of FBN1 mRNA CTD PMID:21178816 NCBI chr 3:133,007,693...133,204,277
Ensembl chr 3:133,008,361...133,204,283
JBrowse link
G Fga fibrinogen alpha chain affects secretion EXP Morphine affects the secretion of FGA protein modified form CTD PMID:24855564 NCBI chr 2:170,672,169...170,679,572
Ensembl chr 2:170,672,012...170,679,577
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases secretion
multiple interactions
ISO Morphine results in decreased secretion of FGF2 protein
Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
CTD PMID:20564181 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression EXP Morphine results in increased expression of FGFR1 mRNA CTD PMID:15183518 NCBI chr16:73,194,631...73,249,855
Ensembl chr16:73,194,631...73,249,855
JBrowse link
G Fh fumarate hydratase increases expression EXP Morphine results in increased expression of FH protein CTD PMID:23056601 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627
JBrowse link
G Fhl2 four and a half LIM domains 2 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of FHL2 protein] CTD PMID:23056601 NCBI chr 9:52,881,091...52,954,540
Ensembl chr 9:52,880,998...52,923,326
JBrowse link
G Fn1 fibronectin 1 increases expression ISO Morphine results in increased expression of FN1 mRNA CTD PMID:20144693 NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:80,645,507...80,714,137
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
affects expression
increases expression
ISO
EXP
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased expression of FOS protein; [Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]; Plant Extracts inhibits the reaction [Morphine results in increased expression of FOS protein]
Morphine deficiency affects the expression of FOS protein
Morphine results in increased expression of FOS mRNA; Morphine results in increased expression of FOS protein
Morphine affects the expression of FOS mRNA
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Morphine results in increased expression of FOS protein]; [Morphine co-treated with Cocaine] affects the expression of FOS; [Morphine co-treated with N-Methyl-3,4-methylenedioxyamphetamine] affects the expression of FOS; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; [SCH772984 co-treated with bilobalide] inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; Genistein inhibits the reaction [Morphine results in increased expression of FOS protein]; Morphine affects the reaction [Formaldehyde results in increased expression of FOS protein]; N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide inhibits the reaction [Morphine results in increased expression of FOS protein]; Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]; SCH772984 inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased expression of FOS protein]]; U 0126 inhibits the reaction [Morphine results in increased expression of FOS protein]
CTD PMID:10521585 PMID:10814832 PMID:12821175 PMID:12934646 PMID:15183518 More... NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP
ISO
Agmatine inhibits the reaction [Morphine results in increased expression of FOSB protein]
morphine increases expression of Fosb protein in nucleus accumbens and caudate-putamen
morphine increases expression of FosB mRNA in striatum
morphine increases expression of Fosb protein in the Brainstem
morphine increases expression of Fosb protein in brain
Morphine results in increased expression of FOSB mRNA
Morphine results in increased expression of FOSB mRNA; Morphine results in increased expression of FOSB protein; Morphine results in increased expression of FOSB protein alternative form; Morphine results in increased expression of FOSB protein modified form
CTD
RGD
PMID:15899480 PMID:18293355 PMID:22454534 PMID:23185589 PMID:19324071 More... RGD:401901600, RGD:401901284, RGD:401851072, RGD:401900159, RGD:401851068 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477
JBrowse link
G Foxp1 forkhead box P1 increases expression
decreases expression
ISO Morphine results in increased expression of FOXP1 mRNA
Morphine deficiency results in decreased expression of FOXP1 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:133,122,055...133,500,272
JBrowse link
G Fxyd7 FXYD domain-containing ion transport regulator 7 decreases expression ISO Morphine results in decreased expression of FXYD7 mRNA CTD PMID:21955143 NCBI chr 1:86,277,678...86,286,954
Ensembl chr 1:95,405,225...95,414,345
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression
increases expression
EXP Morphine results in decreased expression of GABRA1 mRNA
Morphine results in increased expression of GABRA1 mRNA
CTD PMID:15183518 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:27,096,740...27,152,442
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression ISO Morphine results in increased expression of GABRA4 mRNA CTD PMID:21178816 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,944,388...37,021,648
JBrowse link
G Gabrd gamma-aminobutyric acid type A receptor subunit delta increases expression EXP Morphine results in increased expression of GABRD mRNA CTD PMID:15183518 NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:171,240,789...171,253,094
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 increases expression ISO Morphine results in increased expression of GABRG2 mRNA CTD PMID:21955143 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,876,926...26,965,523
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Morphine results in increased expression of GAD1 mRNA CTD PMID:15673448 PMID:18312583 NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:75,777,534...75,818,759
JBrowse link
G Gad2 glutamate decarboxylase 2 increases expression ISO Morphine results in increased expression of GAD2 mRNA CTD PMID:21178816 NCBI chr17:89,671,718...89,734,246
Ensembl chr17:89,671,716...89,941,089
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression
decreases expression
ISO Morphine results in increased expression of GAL mRNA
Morphine results in decreased expression of GAL mRNA
CTD PMID:21178816 PMID:21955143 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:210,079,702...210,084,229
JBrowse link
G Galr1 galanin receptor 1 increases expression ISO morphine co-treated with naltrexone increases expression of Galr1 in locus ceruleus RGD PMID:10882839 RGD:407984714 NCBI chr18:75,772,021...75,787,577
Ensembl chr18:78,046,805...78,062,359
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase decreases expression EXP Morphine results in decreased expression of GAPDH protein CTD PMID:23056601 NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:159,648,592...159,653,377
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 increases expression
decreases expression
ISO Morphine results in increased expression of GCNT2 mRNA
Morphine deficiency results in decreased expression of GCNT2 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr17:24,002,592...24,107,339
Ensembl chr17:24,002,597...24,106,989
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
multiple interactions
ISO
EXP
Morphine results in decreased expression of GFAP mRNA
[lead acetate co-treated with Morphine] results in increased expression of GFAP mRNA
CTD PMID:21955143 PMID:26478469 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 decreases expression EXP Morphine results in decreased expression of GFM1 protein CTD PMID:23056601 NCBI chr 2:154,010,601...154,055,523
Ensembl chr 2:154,010,614...154,065,805
JBrowse link
G Gh1 growth hormone 1 decreases expression
increases secretion
ISO
EXP
Morphine results in decreased expression of GH mRNA
Morphine results in increased secretion of GH1 protein
CTD PMID:7201058 PMID:21178816 NCBI chr10:91,727,883...91,729,860
Ensembl chr10:91,727,884...91,729,859
JBrowse link
G Gjc2 gap junction protein, gamma 2 decreases expression ISO Morphine results in decreased expression of GJC2 mRNA CTD PMID:21955143 NCBI chr10:44,462,203...44,470,924
Ensembl chr10:44,462,054...44,470,340
JBrowse link
G Glra2 glycine receptor, alpha 2 increases expression ISO Morphine results in increased expression of GLRA2 mRNA CTD PMID:21178816 NCBI chr  X:29,020,377...29,241,666
Ensembl chr  X:32,652,187...32,873,277
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression
multiple interactions
increases expression
EXP
ISO
Morphine results in decreased expression of GNAI2 mRNA
Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]
Morphine results in increased expression of GNAI2 mRNA
CTD PMID:15183518 PMID:18652891 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622
JBrowse link
G Gnas GNAS complex locus increases expression EXP Morphine results in increased expression of GNAS mRNA; Morphine results in increased expression of GNAS protein CTD PMID:17893922 NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:183,503,243...183,554,536
JBrowse link
G Gnaz G protein subunit alpha z multiple interactions ISO Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,020...13,669,287
JBrowse link
G Gng11 G protein subunit gamma 11 decreases expression ISO Morphine results in decreased expression of GNG11 mRNA CTD PMID:21955143 NCBI chr 4:32,977,681...32,983,121
Ensembl chr 4:32,977,664...32,984,438
JBrowse link
G Gng2 G protein subunit gamma 2 increases expression EXP Morphine results in increased expression of GNG2 mRNA CTD PMID:15183518 NCBI chr15:4,316,038...4,416,918
Ensembl chr15:4,365,135...4,466,059
JBrowse link
G Gpr6 G protein-coupled receptor 6 decreases expression ISO Morphine results in decreased expression of GPR6 mRNA CTD PMID:21955143 NCBI chr20:44,489,853...44,492,624
Ensembl chr20:46,072,453...46,075,875
JBrowse link
G Gpr88 G-protein coupled receptor 88 increases expression
decreases expression
ISO Morphine results in increased expression of GPR88 mRNA
Morphine deficiency results in decreased expression of GPR88 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 2:206,876,373...206,885,034
Ensembl chr 2:206,868,585...206,884,945
JBrowse link
G Gprc5b G protein-coupled receptor, class C, group 5, member B decreases expression ISO Morphine results in decreased expression of GPRC5B mRNA CTD PMID:21955143 NCBI chr 1:182,748,247...182,772,711
Ensembl chr 1:182,748,247...182,772,757
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 affects response to substance
increases localization
increases expression
decreases phosphorylation
affects expression
increases phosphorylation
multiple interactions
decreases expression
ISO
EXP
GRIA1 protein affects the susceptibility to Morphine
Morphine increases localization of Gria1 protein on shell of nucleus accumbens cell surface
Morphine increases expression of Gria protein in the nucleus accumbens
Morphine increases localization of Gria1 protein on nucleus accumbens cell surface
Morphine decreases phosphorylation of Gria1 protein in the caudate-putamen, nucleus accumbens
Morphine alters expression of Gria1 protein in prefrontal cortex membrane
Morphine withdrawal increases phosphorylation of Gria1 protein in hippocampal formation postsynaptic density
Morphine increases expression of Gria1 protein in the striatum
Morphine increases expression of Gria1 protein in the central amygdaloid nucleus
Morphine promotes the reaction [CREB1 protein modified form binds to GRIA1 promoter]
Morphine results in increased expression of GRIA1 mRNA
Morphine results in decreased expression of GRIA1 mRNA; Morphine results in decreased expression of GRIA1 protein
Morphine results in decreased phosphorylation of GRIA1 protein
CTD
RGD
PMID:11404432 PMID:15183518 PMID:15287884 PMID:23711322 PMID:25643298 More... RGD:11087075, RGD:405818276, RGD:405650668, RGD:405650198, RGD:405649863, RGD:405101691, RGD:405100728, RGD:405100238 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 decreases expression EXP Morphine results in decreased expression of GRIA2 protein CTD PMID:23711322 NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:168,247,496...168,367,616
JBrowse link
G Gria3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP Morphine results in decreased expression of GRIA3 mRNA CTD PMID:15183518 NCBI chr  X:125,103,975...125,369,690
Ensembl chr  X:125,103,782...125,369,679
JBrowse link
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 decreases expression EXP Morphine results in decreased expression of GRIA4 mRNA CTD PMID:15183518 NCBI chr 8:1,562,118...2,035,035
Ensembl chr 8:9,847,052...10,319,881
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 multiple interactions
affects response to substance
ISO GRIK1 protein affects the reaction [Morphine results in increased expression of CALCA protein]; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
GRIK1 protein affects the susceptibility to Morphine
CTD PMID:20359526 NCBI chr11:40,655,974...41,056,966
Ensembl chr11:40,655,975...41,056,517
JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions
increases expression
increases phosphorylation
decreases phosphorylation
affects phosphorylation
ISO
EXP
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]
morphine increases expression of Nr1 protein in cortical neurons
morphine increases phosphorylation of Nr1 protein in frontal cortex and cortical neurons
Morphine results in increased expression of GRIN1 protein
Agmatine inhibits the reaction [Morphine results in increased expression of GRIN1 protein]; Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN1 protein]
Morphine results in decreased phosphorylation of GRIN1 protein
Morphine affects the phosphorylation of GRIN1 protein
CTD
RGD
PMID:15287884 PMID:17996026 PMID:20519536 PMID:20950603 PMID:22713680 More... RGD:401901284, RGD:401901284 NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:28,501,836...28,528,754
JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression
affects response to substance
ISO Morphine results in increased expression of GRIN2A protein
GRIN2A protein affects the susceptibility to Morphine
CTD PMID:12878694 PMID:33609567 NCBI chr10:6,136,458...6,560,003
Ensembl chr10:6,138,037...6,551,378
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases expression
increases phosphorylation
ISO
EXP
MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]
Morphine results in increased expression of GRIN2B protein
Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of [GRIN1 protein binds to GRIN2B protein binds to DLG4 protein]]; resveratrol inhibits the reaction [Morphine results in increased expression of GRIN2B protein]
CTD PMID:20519536 PMID:22713680 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
JBrowse link
G Grin2c glutamate ionotropic receptor NMDA type subunit 2C increases expression EXP Morphine results in increased expression of GRIN2C mRNA CTD PMID:15183518 NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,987,513...101,005,409
JBrowse link
G Grk5 G protein-coupled receptor kinase 5 increases expression EXP Morphine results in increased expression of GRK5 mRNA CTD PMID:15183518 NCBI chr 1:270,014,314...270,208,294
Ensembl chr 1:270,014,282...270,204,928
JBrowse link
G Grm1 glutamate metabotropic receptor 1 increases expression EXP Morphine results in increased expression of GRM1 mRNA CTD PMID:15183518 NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:6,878,545...7,273,443
JBrowse link
G Grm5 glutamate metabotropic receptor 5 increases expression
decreases expression
ISO Morphine results in increased expression of GRM5 mRNA
Morphine deficiency results in decreased expression of GRM5 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 1:150,722,711...151,297,585
Ensembl chr 1:150,733,678...151,296,649
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions
ISO Morphine results in increased expression of GSK3B protein modified form
Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form]
CTD PMID:20600172 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Hcrtr1 hypocretin receptor 1 increases expression EXP Morphine results in increased expression of HCRTR1 mRNA; Morphine results in increased expression of HCRTR1 protein CTD PMID:32319158 NCBI chr 5:142,477,214...142,486,674
Ensembl chr 5:147,760,145...147,770,850
JBrowse link
G Hdac5 histone deacetylase 5 increases expression EXP Morphine results in increased expression of HDAC5 protein CTD PMID:35461814 NCBI chr10:87,653,139...87,688,078
Ensembl chr10:87,652,656...87,694,244
JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 multiple interactions
increases response to substance
ISO HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
HINT1 gene mutant form results in increased susceptibility to Morphine
CTD PMID:18652891 PMID:21235400 NCBI chr10:39,490,225...39,493,970
Ensembl chr 4:93,430,926...93,431,642
Ensembl chr10:93,430,926...93,431,642
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 decreases expression ISO Morphine results in decreased expression of HMGCS1 mRNA CTD PMID:21955143 NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:53,382,643...53,399,802
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 increases expression ISO Morphine results in increased expression of HMGCS2 mRNA CTD PMID:20144693 NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:188,547,767...188,592,242
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Morphine results in increased expression of HMOX1 protein CTD PMID:14871405 NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
JBrowse link
G Hmox2 heme oxygenase 2 decreases activity
increases activity
EXP Morphine results in decreased activity of HMOX2 protein
Morphine results in increased activity of HMOX2 protein
CTD PMID:12812915 NCBI chr10:11,303,512...11,337,640
Ensembl chr10:11,303,512...11,318,800
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like increases expression ISO Morphine results in increased expression of HNRNPDL mRNA CTD PMID:20144693 NCBI chr14:9,861,716...9,867,945
Ensembl chr14:9,861,716...9,867,945
JBrowse link
G Hnrnpl heterogeneous nuclear ribonucleoprotein L increases expression ISO Morphine deficiency results in increased expression of HNRNPL mRNA; Morphine results in increased expression of HNRNPL mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 1:93,226,373...93,239,084
Ensembl chr 1:93,235,729...93,239,061
JBrowse link
G Homer1 homer scaffold protein 1 increases expression ISO Morphine results in increased expression of HOMER1 mRNA CTD PMID:21955143 NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657
JBrowse link
G Hp haptoglobin decreases expression EXP Morphine results in decreased expression of HP protein CTD PMID:23056601 NCBI chr19:54,449,151...54,453,701
Ensembl chr19:54,446,217...54,467,518
JBrowse link
G Hpca hippocalcin increases expression
decreases expression
ISO Morphine results in increased expression of HPCA mRNA
Morphine deficiency results in decreased expression of HPCA mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:146,739,978...146,749,983
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases response to substance
ISO Chlorpheniramine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine] CTD PMID:12128009 PMID:14569158 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:149,120,039...149,208,248
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases response to substance
ISO [zolantidine binds to and results in decreased activity of HRH2 protein] which results in increased susceptibility to Morphine; Chlorpheniramine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]
HRH2 protein results in decreased susceptibility to Morphine; HRH2 results in decreased susceptibility to Morphine
CTD PMID:14569158 PMID:16806305 NCBI chr17:10,371,083...10,412,979
Ensembl chr17:10,371,083...10,391,041
JBrowse link
G Hs6st2 heparan sulfate 6-O-sulfotransferase 2 increases expression ISO Morphine results in increased expression of HS6ST2 mRNA CTD PMID:21178816 NCBI chr  X:130,966,547...131,261,629
Ensembl chr  X:135,888,472...136,182,353
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Morphine results in decreased expression of HSD11B1 mRNA CTD PMID:21955143 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP Morphine results in increased expression of HSP90AB1 mRNA CTD PMID:15497504 NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:22,931,070...22,935,926
JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 decreases expression EXP Morphine results in decreased expression of HSP90B1 protein CTD PMID:23056601 NCBI chr 7:22,997,962...23,012,293
Ensembl chr 7:22,997,962...23,012,293
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions
increases expression
EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA]
Morphine results in increased expression of HSPA1A mRNA; Morphine results in increased expression of HSPA1A protein
CTD PMID:15497504 PMID:23056601 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Morphine results in increased expression of HSPA5 protein
corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]
CTD PMID:37394652 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression EXP Morphine results in increased expression of HSPA8 mRNA CTD PMID:15497504 NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:50,080,199...50,084,372
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression EXP Morphine results in increased expression of HSPB1 mRNA; Morphine results in increased expression of HSPB1 protein CTD PMID:15497504 PMID:23056601 NCBI chr12:26,430,640...26,432,301
Ensembl chr12:26,430,640...26,432,301
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Morphine results in increased expression of HSPE1 protein CTD PMID:23056601 NCBI chr 9:64,084,327...64,087,415
Ensembl chr 9:64,085,068...64,087,502
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions
decreases expression
EXP 4-(2'-methoxyphenyl)-1-(2'-(N-(2''-pyridinyl)-4-iodobenzamido)ethyl)piperazine inhibits the reaction [[8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine]; [8-Hydroxy-2-(di-n-propylamino)tetralin binds to and results in increased activity of HTR1A protein] which results in decreased susceptibility to Morphine
Morphine decreases expression of Htr1a mRNA in the dorsal raphe nucleus
CTD
RGD
PMID:10640309 PMID:24055683 RGD:405866344 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A increases expression ISO Morphine results in increased expression of HTR3A mRNA CTD PMID:21178816 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
EXP Morphine results in decreased expression of ICAM1 protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form]
CTD PMID:10070497 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Idh3b isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit beta decreases expression
multiple interactions
EXP Morphine results in decreased expression of IDH3B protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of IDH3B protein]
CTD PMID:23056601 NCBI chr 3:117,481,845...117,486,909
Ensembl chr 3:137,934,697...137,940,107
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO Morphine results in decreased expression of IFNG
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]
CTD PMID:11590188 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Igsf1 immunoglobulin superfamily, member 1 decreases expression ISO Morphine results in decreased expression of IGSF1 mRNA CTD PMID:21955143 NCBI chr  X:133,947,717...133,963,154
Ensembl chr  X:133,947,429...133,962,962
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Morphine affects the expression of [IL12A protein binds to IL12B protein] CTD PMID:16299287 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:155,275,625...155,282,997
JBrowse link
G Il12b interleukin 12B multiple interactions
affects expression
ISO Morphine affects the expression of [IL12A protein binds to IL12B protein]
Morphine affects the expression of IL12B protein
CTD PMID:16299287 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194
JBrowse link
G Il13 interleukin 13 increases expression ISO Morphine results in increased expression of IL13 protein CTD PMID:16210602 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
JBrowse link
G Il1a interleukin 1 alpha multiple interactions
decreases expression
ISO Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]; Dexamethasone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Dexamethasone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]]; Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]; Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
increases secretion
EXP
ISO
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL1B protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL1B mRNA]
corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL1B protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]
Morphine results in increased expression of IL1B mRNA; Morphine results in increased expression of IL1B protein
Morphine results in increased secretion of IL1B protein
CTD PMID:12427855 PMID:20178837 PMID:21081778 PMID:22713680 PMID:24756886 More... NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il1rn interleukin 1 receptor antagonist affects response to substance ISO IL1RN protein affects the susceptibility to Morphine CTD PMID:15317861 NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:27,509,798...27,525,732
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
ISO Morphine results in decreased expression of IL2
Morphine results in decreased expression of IL2 mRNA
OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]
CTD PMID:11590188 PMID:23965172 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il4 interleukin 4 multiple interactions
increases expression
ISO [FAS protein binds to FASL protein] affects the reaction [Morphine results in increased expression of IL4 protein]
Morphine results in increased expression of IL4 mRNA; Morphine results in increased expression of IL4 protein
CTAP octapeptide inhibits the reaction [Morphine results in increased expression of IL4 mRNA]; SB 203580 inhibits the reaction [Morphine results in increased expression of IL4 mRNA]
CTD PMID:16210602 PMID:23965172 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
increases expression
ISO
EXP
Morphine results in increased secretion of IL6 protein
corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of IL6 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]
Morphine results in increased expression of IL6 mRNA; Morphine results in increased expression of IL6 protein
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of IL6 protein]; resveratrol inhibits the reaction [Morphine results in increased expression of IL6 mRNA]
CTD PMID:12427855 PMID:15317861 PMID:20564181 PMID:21081778 PMID:22713680 More... NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Ing2 inhibitor of growth family, member 2 multiple interactions EXP Morphine promotes the reaction [ING2 protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr16:51,305,311...51,316,177
Ensembl chr16:51,307,466...51,316,177
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Morphine results in increased expression of ITGAM mRNA CTD PMID:37981055 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Acetylcysteine inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein]; Morphine results in increased phosphorylation of and results in increased activity of JUN protein; pyrazolanthrone inhibits the reaction [Morphine results in increased phosphorylation of and results in increased activity of JUN protein] CTD PMID:19292871 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Morphine results in increased expression of JUNB mRNA CTD PMID:21955143 NCBI chr19:40,081,126...40,082,910
Ensembl chr19:40,073,541...40,085,218
JBrowse link
G Klf7 KLF transcription factor 7 increases expression
multiple interactions
ISO Morphine results in increased expression of KLF7 mRNA; Morphine results in increased expression of KLF7 protein
Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA]
CTD PMID:14644156 NCBI chr 9:72,927,485...73,020,167
Ensembl chr 9:72,933,136...73,020,056
JBrowse link
G Klrk1 killer cell lectin like receptor K1 decreases expression ISO Morphine results in decreased expression of KLRK1 mRNA CTD PMID:20144693 NCBI chr 4:164,767,377...164,778,453
Ensembl chr 4:164,767,946...164,778,382
JBrowse link
G Kmt2a lysine methyltransferase 2A multiple interactions
affects expression
EXP
ISO
Morphine promotes the reaction [KMT2A protein binds to BDNF promoter]
Morphine affects the expression of KMT2A mRNA
CTD PMID:25643298 PMID:33891991 NCBI chr 8:54,013,547...54,089,219
Ensembl chr 8:54,013,547...54,089,317
JBrowse link
G Krt1 keratin 1 decreases expression EXP Morphine results in decreased expression of KRT1 protein CTD PMID:23056601 NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:134,855,313...134,860,537
JBrowse link
G Krt10 keratin 10 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of KRT10 protein] CTD PMID:23056601 NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,834,840...84,839,160
JBrowse link
G Krt2 keratin 2 decreases expression
multiple interactions
EXP Morphine results in decreased expression of KRT2 protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT2 protein]
CTD PMID:23056601 NCBI chr 7:132,940,879...132,948,031
Ensembl chr 7:134,819,584...134,827,011
JBrowse link
G Krt33a keratin 33A multiple interactions
increases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein]]; Morphine deficiency promotes the reaction [Morphine results in increased expression of KRT33A protein] CTD PMID:23056601 NCBI chr10:84,942,584...84,947,544
Ensembl chr10:85,442,988...85,447,947
JBrowse link
G Krt42 keratin 42 decreases expression EXP Morphine results in decreased expression of KRT42 protein CTD PMID:23056601 NCBI chr10:85,185,186...85,246,520
Ensembl chr10:85,685,564...85,692,988
JBrowse link
G Krt5 keratin 5 decreases expression EXP Morphine results in decreased expression of KRT5 protein CTD PMID:23056601 NCBI chr 7:134,724,840...134,730,569
Ensembl chr 7:134,724,840...134,730,569
JBrowse link
G Krt8 keratin 8 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein]]; Morphine deficiency affects the reaction [Morphine results in decreased expression of KRT8 protein] CTD PMID:23056601 NCBI chr 7:135,002,886...135,010,339
Ensembl chr 7:135,002,894...135,010,403
JBrowse link
G Lcn2 lipocalin 2 increases expression ISO Morphine results in increased expression of LCN2 mRNA CTD PMID:20144693 NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:36,078,436...36,081,842
JBrowse link
G Lepr leptin receptor increases expression ISO Morphine results in increased expression of LEPR mRNA CTD PMID:20144693 NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:121,474,099...121,591,215
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Morphine results in decreased expression of LHB protein CTD PMID:7022252 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
JBrowse link
G Lin7c lin-7 homolog C, crumbs cell polarity complex component decreases expression ISO Morphine results in decreased expression of LIN7C mRNA CTD PMID:21955143 NCBI chr 3:116,859,425...116,872,363
Ensembl chr 3:116,860,282...116,872,363
JBrowse link
G Litaf lipopolysaccharide-induced TNF factor decreases expression ISO Morphine results in decreased expression of LITAF mRNA CTD PMID:21955143 NCBI chr10:5,163,258...5,199,930
Ensembl chr10:5,163,242...5,199,930
JBrowse link
G Lmo7 LIM domain 7 increases expression ISO Morphine results in increased expression of LMO7 mRNA CTD PMID:21955143 NCBI chr15:84,981,689...85,184,554
Ensembl chr15:84,981,735...85,184,551
JBrowse link
G Lmx1b LIM homeobox transcription factor 1 beta increases expression ISO Morphine results in increased expression of LMX1B mRNA CTD PMID:19397953 NCBI chr 3:16,862,195...16,940,899
Ensembl chr 3:37,259,855...37,338,557
JBrowse link
G Lpl lipoprotein lipase increases expression ISO Morphine results in increased expression of LPL mRNA CTD PMID:21955143 NCBI chr16:25,596,205...25,621,928
Ensembl chr16:25,596,211...25,622,107
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Morphine results in decreased expression of LRP1 mRNA CTD PMID:21178816 NCBI chr 7:65,265,639...65,346,196
Ensembl chr 7:65,265,639...65,346,196
JBrowse link
G Lrpprc leucine-rich pentatricopeptide repeat containing increases expression ISO Morphine results in increased expression of LRPPRC mRNA CTD PMID:20144693 NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:15,612,655...15,695,116
JBrowse link
G Map2 microtubule-associated protein 2 decreases expression EXP Morphine results in decreased expression of MAP2 mRNA CTD PMID:15183518 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:75,288,262...75,428,459
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
increases phosphorylation
multiple interactions
ISO
EXP
Morphine results in increased expression of MAPK1 protein modified form
Morphine results in increased phosphorylation of MAPK1 protein
[Morphine co-treated with Dehydroepiandrosterone Sulfate] results in decreased phosphorylation of MAPK1 protein; AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
Morphine deficiency results in increased phosphorylation of MAPK1 protein; Morphine results in increased phosphorylation of MAPK1 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK1 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]
CTD PMID:15196791 PMID:20359526 PMID:20519536 PMID:21235400 PMID:21483469 More... NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk14 mitogen activated protein kinase 14 increases expression EXP Morphine results in increased expression of MAPK14 protein CTD PMID:23056601 NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,751,357...6,812,294
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein; Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
AM 251 inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; suvorexant inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine deficiency results in increased phosphorylation of MAPK3 protein; Morphine results in increased phosphorylation of MAPK3 protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of MAPK3 protein]; ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; bilobalide inhibits the reaction [Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]]; Oxaliplatin promotes the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
CTD PMID:20519536 PMID:21235400 PMID:21483469 PMID:21600884 PMID:23965172 More... NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mapt microtubule-associated protein tau increases expression EXP Morphine results in increased expression of MAPT mRNA CTD PMID:15183518 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression EXP Morphine results in decreased expression of MARCKS protein CTD PMID:23056601 NCBI chr20:42,240,185...42,245,882
Ensembl chr20:42,240,185...42,245,882
JBrowse link
G Mavs mitochondrial antiviral signaling protein increases expression EXP Morphine results in increased expression of MAVS protein CTD PMID:23056601 NCBI chr 3:138,904,673...138,919,129
Ensembl chr 3:138,904,771...138,919,126
JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 affects expression ISO Morphine affects the expression of MBD1 mRNA CTD PMID:33891991 NCBI chr18:70,145,093...70,159,744
Ensembl chr18:70,145,114...70,159,703
JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 decreases expression ISO Morphine results in decreased expression of MBD3 mRNA CTD PMID:33891991 NCBI chr 7:9,961,053...9,970,845
Ensembl chr 7:9,963,797...9,970,265
JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase affects expression ISO Morphine affects the expression of MBD4 mRNA CTD PMID:33891991 NCBI chr 4:150,565,646...150,577,433
Ensembl chr 4:150,565,655...150,577,578
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Morphine results in increased expression of MCL1 mRNA CTD PMID:20144693 NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:185,908,168...185,938,782
JBrowse link
G Mctp1 multiple C2 and transmembrane domain containing 1 increases expression ISO Morphine results in increased expression of MCTP1 mRNA CTD PMID:21955143 NCBI chr 2:7,798,968...8,493,596
Ensembl chr 2:7,803,382...8,493,596
JBrowse link
G Me3 malic enzyme 3 increases expression ISO Morphine results in increased expression of ME3 mRNA CTD PMID:21178816 NCBI chr 1:143,534,024...143,735,551
Ensembl chr 1:152,946,628...153,148,026
JBrowse link
G Mir107 microRNA 107 decreases expression ISO Morphine results in decreased expression of MIR107 CTD PMID:20564181 NCBI chr 1:241,750,418...241,750,504 JBrowse link
G Mir132 microRNA 132 increases expression ISO Morphine results in increased expression of MIR132 CTD PMID:20564181 NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,522,033...60,522,133
JBrowse link
G Mir146a microRNA 146a increases expression ISO Morphine results in increased expression of MIR146A CTD PMID:20564181 NCBI chr10:28,349,996...28,350,090 JBrowse link
G Mir150 microRNA 150 increases expression ISO Morphine results in increased expression of MIR150 CTD PMID:20564181 NCBI chr 1:104,741,487...104,741,571
Ensembl chr 1:104,741,487...104,741,571
JBrowse link
G Mir155 microRNA 155 increases expression ISO Morphine results in increased expression of MIR155 CTD PMID:20564181 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:37,261,114...37,261,178
JBrowse link
G Mir15b microRNA 15b increases expression ISO Morphine results in increased expression of MIR15B CTD PMID:20564181 NCBI chr 2:155,555,178...155,555,275
Ensembl chr 2:155,555,178...155,555,275
JBrowse link
G Mir191 microRNA 191 decreases expression ISO Morphine results in decreased expression of MIR191 CTD PMID:20564181 NCBI chr 8:118,142,627...118,142,717 JBrowse link
G Mir21 microRNA 21 decreases expression ISO Morphine results in decreased expression of MIR21 CTD PMID:20564181 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mir221 microRNA 221 increases expression ISO Morphine results in increased expression of MIR221 CTD PMID:20564181 NCBI chr  X:6,023,182...6,023,290
Ensembl chr  X:6,023,182...6,023,290
JBrowse link
G Mir23a microRNA 23a increases expression ISO Morphine results in increased expression of MIR23A CTD PMID:20564181 NCBI chr19:23,954,997...23,955,071 JBrowse link
G Mir23b microRNA 23b increases expression ISO Morphine results in increased expression of MIR23B CTD PMID:20564181 NCBI chr17:1,819,386...1,819,482 JBrowse link
G Mir26a1 microRNA 26a-1 decreases expression ISO Morphine results in decreased expression of MIR26A1 CTD PMID:20564181 NCBI chr 8:127,633,048...127,633,137
Ensembl chr 8:127,633,048...127,633,137
JBrowse link
G Mir26b microRNA 26b decreases expression ISO Morphine results in decreased expression of MIR26B CTD PMID:20564181 NCBI chr 9:83,425,709...83,425,793
Ensembl chr 9:83,425,709...83,425,793
JBrowse link
G Mir320a microRNA 320a decreases expression ISO Morphine results in decreased expression of MIR320A CTD PMID:20564181 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:51,926,088...51,926,169
JBrowse link
G Mir423 microRNA 423 decreases expression ISO Morphine results in decreased expression of MIR423 CTD PMID:20564181 NCBI chr10:61,914,142...61,914,220 JBrowse link
G Mir99b microRNA 99b decreases expression ISO Morphine results in decreased expression of MIR99B CTD PMID:20564181 NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:67,350,060...67,350,139
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions
increases activity
EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein]; phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases activity
ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of GRIN2B protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; MMP9 protein affects the reaction [Morphine results in increased phosphorylation of MAPK3 protein]
Morphine results in increased activity of MMP9 protein
CTD PMID:20519536 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mpeg1 macrophage expressed 1 increases expression ISO Morphine results in increased expression of MPEG1 mRNA CTD PMID:21178816 NCBI chr 1:218,876,848...218,881,364
Ensembl chr 1:218,876,069...218,908,715
JBrowse link
G Myo19 myosin XIX decreases expression ISO Morphine results in decreased expression of MYO19 mRNA CTD PMID:21178816 NCBI chr10:70,250,500...70,279,867
Ensembl chr10:70,250,022...70,279,858
JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 increases expression EXP Morphine results in increased expression of NAIP mRNA CTD PMID:15183518 NCBI chr 2:33,241,520...33,293,184
Ensembl chr 2:33,241,521...33,276,859
JBrowse link
G Nav1 neuron navigator 1 decreases expression ISO Morphine results in decreased expression of NAV1 mRNA CTD PMID:21178816 NCBI chr13:49,418,755...49,671,117
Ensembl chr13:49,418,755...49,671,004
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression EXP Morphine results in decreased expression of NCAM1 protein modified form CTD PMID:15673448 NCBI chr 8:58,762,088...59,062,131
Ensembl chr 8:58,762,116...59,061,971
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 affects expression ISO Morphine affects the expression of NDUFAB1 mRNA CTD PMID:20144693 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:186,057,113...186,089,373
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 increases expression EXP Morphine results in increased expression of NDUFV2 protein CTD PMID:23056601 NCBI chr 9:113,137,305...113,157,571
Ensembl chr 9:113,137,306...113,157,520
JBrowse link
G Nefh neurofilament heavy chain increases expression EXP Morphine results in increased expression of NEFH mRNA CTD PMID:15183518 NCBI chr14:84,044,428...84,054,413
Ensembl chr14:84,044,023...84,054,417
JBrowse link
G Nes nestin decreases expression ISO Morphine results in decreased expression of NES mRNA CTD PMID:26877219 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression EXP Morphine results in increased expression of NFKB1 mRNA CTD PMID:15183518 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088
JBrowse link
G Nfkbia NFKB inhibitor alpha increases phosphorylation
affects response to substance
increases expression
increases degradation
multiple interactions
ISO
EXP
Morphine results in increased phosphorylation of NFKBIA protein
NFKBIA protein affects the susceptibility to Morphine
Morphine results in increased expression of NFKBIA protein
Morphine results in increased degradation of NFKBIA protein
Morphine results in increased expression of NFKBIA mRNA; Morphine results in increased expression of NFKBIA protein
Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Cycloheximide inhibits the reaction [Morphine results in increased expression of NFKBIA mRNA]; Morphine inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
CTD PMID:17542780 PMID:19070643 PMID:22258905 PMID:24068670 NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
JBrowse link
G Ninj1 ninjurin 1 increases expression ISO Morphine results in increased expression of NINJ1 mRNA CTD PMID:19397953 NCBI chr17:15,659,208...15,668,115
Ensembl chr17:15,659,200...15,668,063
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
ISO corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of NLRP3 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]] CTD PMID:37394652 NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,828,014...44,853,394
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases expression
increases expression
ISO
EXP
[7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]
Morphine results in decreased expression of NOS1 protein
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]
CTD PMID:16598705 PMID:20519536 PMID:20568289 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
affects response to substance
ISO Morphine results in increased expression of NOS2 mRNA; Morphine results in increased expression of NOS2 protein
corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]
NOS2 protein affects the susceptibility to Morphine
CTD PMID:11590188 PMID:15220775 PMID:16325209 PMID:19751225 PMID:24756886 More... NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Npy neuropeptide Y increases expression ISO Morphine results in increased expression of NPY mRNA CTD PMID:20144693 PMID:21178816 NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:80,212,111...80,219,310
JBrowse link
G Npy1r neuropeptide Y receptor Y1 decreases expression ISO Morphine results in decreased expression of NPY1R mRNA CTD PMID:20144693 NCBI chr16:27,804,416...27,814,070
Ensembl chr16:27,804,416...27,813,387
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions EXP [Mifepristone binds to and results in decreased activity of NR3C1 protein] which results in decreased susceptibility to Morphine CTD PMID:15014116 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Morphine results in increased expression of NR4A1 mRNA CTD PMID:21955143 NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:134,247,192...134,268,041
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions
decreases expression
affects response to substance
ISO
EXP
BDNF protein inhibits the reaction [NR4A2 protein affects the susceptibility to Morphine]
Morphine results in decreased expression of NR4A2 mRNA
Morphine inhibits the reaction [CREB1 protein modified form binds to NR4A2 promoter]; Morphine inhibits the reaction [NR4A2 protein binds to BDNF promoter]
CTD PMID:25643298 NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:62,098,743...62,106,769
JBrowse link
G Nrcam neuronal cell adhesion molecule increases expression EXP Morphine results in increased expression of NRCAM mRNA; Morphine results in increased expression of NRCAM mRNA alternative form CTD PMID:16123759 NCBI chr 6:67,129,723...67,425,510
Ensembl chr 6:67,129,801...67,430,539
JBrowse link
G Nrn1 neuritin 1 decreases expression ISO Morphine results in decreased expression of NRN1 mRNA CTD PMID:21955143 NCBI chr17:28,129,969...28,138,898
Ensembl chr17:28,334,616...28,344,354
JBrowse link
G Nrxn3 neurexin 3 increases expression ISO Morphine results in increased expression of NRXN3 mRNA CTD PMID:21955143 NCBI chr 6:113,372,667...115,004,073
Ensembl chr 6:113,443,524...115,002,540
JBrowse link
G Ntng1 netrin G1 decreases expression ISO Morphine results in decreased expression of NTNG1 mRNA CTD PMID:21955143 NCBI chr 2:197,462,785...197,827,681
Ensembl chr 2:200,151,979...200,515,031
JBrowse link
G Ntsr1 neurotensin receptor 1 affects response to substance ISO NTSR1 protein affects the susceptibility to Morphine CTD PMID:20727387 NCBI chr 3:167,606,215...167,656,371
Ensembl chr 3:187,983,778...188,033,934
JBrowse link
G Opalin oligodendrocytic myelin paranodal and inner loop protein decreases expression ISO Morphine results in decreased expression of OPALIN mRNA CTD PMID:21955143 NCBI chr 1:239,891,137...239,909,388
Ensembl chr 1:249,840,539...249,858,190
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
increases expression
affects binding
ISO
EXP
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK1 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of MAPK3 protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [ARL6IP5 mutant form inhibits the reaction [Morphine results in increased expression of OPRD1 protein]]; Morphine promotes the reaction [ARL6IP5 protein binds to OPRD1 protein]
Morphine binds to OPRD1 protein
CTD PMID:7562497 PMID:21600884 PMID:35477798 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects activity
increases activity
increases expression
affects binding
multiple interactions
ISO
EXP
Morphine affects the activity of OPRK1 protein
Morphine results in increased activity of OPRK1 protein
Morphine results in increased expression of OPRK1 mRNA
Morphine binds to OPRK1 protein
Morphine inhibits the reaction [Zymosan results in decreased expression of OPRK1 mRNA]
CTD PMID:7562497 PMID:15979727 PMID:18385270 PMID:22661197 PMID:26476280 More... NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprl1 opioid related nociceptin receptor 1 multiple interactions ISO [J 113397 binds to and results in decreased activity of OPRL1 protein] which affects the susceptibility to Morphine CTD PMID:11027224 NCBI chr 3:168,831,934...168,839,920
Ensembl chr 3:189,212,175...189,217,426
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
decreases expression
increases phosphorylation
increases activity
affects response to substance
increases expression
affects binding
affects activity
decreases response to substance
ISO
EXP
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; [COMT gene SNP co-treated with OPRM1 gene SNP] affects the susceptibility to Morphine; [OPRM1 protein co-treated with Morphine] results in increased activity of ARRB2 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]; OPRM1 protein affects the reaction [Morphine results in decreased secretion of FGF2 protein]
morphine decreases expression of Oprm1 protein in cultured astrocytes
Morphine results in increased phosphorylation of OPRM1 protein
Morphine results in increased activity of OPRM1 protein
Morphine results in decreased expression of OPRM1 mRNA
OPRM1 affects the susceptibility to Morphine; OPRM1 protein affects the susceptibility to Morphine
[Morphine results in increased activity of OPRM1 protein] which results in increased phosphorylation of GRIN1 protein; [phenylalanyl-cyclo(cysteinyltyrosyl-tryptophyl-ornithyl-threonyl-penicillamine)threoninamide binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Zymosan co-treated with Morphine] results in increased expression of OPRM1 mRNA; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]]; HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein; Morphine promotes the reaction [OPRM1 protein binds to MAPK1 protein]; Morphine promotes the reaction [OPRM1 protein binds to MAPK3 protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IFNG]; OPRM1 gene mutant form inhibits the reaction [Morphine results in decreased expression of IL2]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; valyl-prolyl-aspartyl-prolyl-arginine inhibits the reaction [Morphine results in increased activity of OPRM1 protein]
Morphine results in increased expression of OPRM1 protein
Morphine binds to OPRM1 protein
OPRM1 affects the activity of Morphine
[beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of 3,4-Dihydroxyphenylacetic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] inhibits the reaction [Morphine results in increased abundance of Homovanillic Acid]; [beta-funaltrexamine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; [Morphine binds to and results in increased activity of OPRM1 protein] which results in increased activity of ARRB2 protein; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which affects the susceptibility to Morphine; [naloxonazine binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Morphine; Morphine affects the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to OPRM1 protein]; Morphine binds to and affects the activity of OPRM1 protein; Morphine binds to and results in increased activity of OPRM1 protein
OPRM1 exon SNP results in decreased susceptibility to Morphine
Morphine affects the activity of OPRM1 protein
CTD
RGD
PMID:7562497 PMID:8884884 PMID:9264103 PMID:10803207 PMID:11106302 More... RGD:597978120 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Oxct1 3-oxoacid CoA transferase 1 decreases expression EXP Morphine results in decreased expression of OXCT1 protein CTD PMID:23056601 NCBI chr 2:53,236,370...53,384,715
Ensembl chr 2:54,963,784...55,112,298
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression ISO Morphine results in decreased expression of PATJ mRNA CTD PMID:21955143 NCBI chr 5:113,061,985...113,364,807
Ensembl chr 5:118,177,565...118,480,301
JBrowse link
G Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor increases expression ISO Morphine results in increased expression of PCSK1N mRNA CTD PMID:20144693 NCBI chr  X:17,251,963...17,255,405
Ensembl chr  X:17,251,965...17,257,360
JBrowse link
G Pdcd5 programmed cell death 5 increases expression EXP Morphine results in increased expression of PDCD5 protein CTD PMID:23056601 NCBI chr 1:97,442,755...97,448,084
Ensembl chr 1:97,442,755...97,449,844
JBrowse link
G Pde10a phosphodiesterase 10A decreases expression ISO Morphine deficiency results in decreased expression of PDE10A mRNA; Morphine results in decreased expression of PDE10A mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:54,317,732...54,764,051
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
decreases response to substance
ISO PDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]; PDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]; PDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]
PDGFB protein results in decreased susceptibility to Morphine
CTD PMID:21483469 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:113,420,710...113,438,343
JBrowse link
G Pdhb pyruvate dehydrogenase E1 subunit beta increases expression
multiple interactions
EXP Morphine results in increased expression of PDHB protein
Morphine deficiency affects the reaction [Morphine results in increased expression of PDHB protein]
CTD PMID:23056601 NCBI chr15:16,752,561...16,758,503
Ensembl chr15:19,181,208...19,188,976
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression EXP Morphine results in decreased expression of PDK1 protein CTD PMID:23056601 NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:77,113,473...77,144,145
JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 decreases expression EXP Morphine results in decreased expression of PDK2 protein CTD PMID:23056601 NCBI chr10:80,469,388...80,483,988
Ensembl chr10:80,469,389...80,484,355
JBrowse link
G Pdlim2 PDZ and LIM domain 2 decreases expression ISO Morphine results in decreased expression of PDLIM2 mRNA CTD PMID:21955143 NCBI chr15:51,647,195...51,659,904
Ensembl chr15:51,647,197...51,658,958
JBrowse link
G Pdyn prodynorphin increases expression
decreases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of PDYN protein alternative form
Morphine deficiency results in decreased expression of PDYN mRNA
Morphine results in decreased expression of PDYN mRNA
[Zymosan co-treated with Morphine] results in increased expression of PDYN mRNA; GRIK1 protein affects the reaction [Morphine results in increased expression of PDYN protein alternative form]
CTD PMID:15979727 PMID:17401159 PMID:20359526 PMID:27126842 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503
JBrowse link
G Penk proenkephalin multiple interactions
decreases expression
EXP
ISO
Morphine inhibits the reaction [Formaldehyde results in increased expression of PENK mRNA]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of CALCA protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of NOS1 protein]; PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein]
Morphine deficiency results in decreased expression of PENK mRNA
CTD PMID:7978486 PMID:20568289 PMID:27126842 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705
JBrowse link
G Per1 period circadian regulator 1 affects expression EXP Morphine affects the expression of PER1 mRNA CTD PMID:19383088 NCBI chr10:54,299,002...54,313,804
Ensembl chr10:54,302,641...54,314,211
JBrowse link
G Per2 period circadian regulator 2 affects response to substance
affects expression
ISO
EXP
PER2 protein affects the susceptibility to Morphine
Morphine affects the expression of PER2 mRNA
CTD PMID:19383088 PMID:20434889 NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:99,454,830...99,496,993
JBrowse link
G Perm1 PPARGC1 and ESRR induced regulator, muscle 1 multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine results in increased expression of PERM1 protein] CTD PMID:23056601 NCBI chr 5:172,082,249...172,087,542
Ensembl chr 5:172,082,249...172,087,542
JBrowse link
G Phldb1 pleckstrin homology-like domain, family B, member 1 decreases expression ISO Morphine results in decreased expression of PHLDB1 mRNA CTD PMID:21955143 NCBI chr 8:53,900,338...53,948,325
Ensembl chr 8:53,900,338...53,949,518
JBrowse link
G Piga phosphatidylinositol glycan anchor biosynthesis, class A decreases expression ISO Morphine results in decreased expression of PIGA mRNA CTD PMID:21955143 NCBI chr  X:30,043,033...30,055,861
Ensembl chr  X:33,674,923...33,687,636
JBrowse link
G Pknox1 PBX/knotted 1 homeobox 1 increases expression ISO Morphine results in increased expression of PKNOX1 mRNA CTD PMID:21178816 NCBI chr20:9,662,866...9,705,030
Ensembl chr20:9,664,312...9,706,349
JBrowse link
G Plat plasminogen activator, tissue type affects response to substance ISO PLAT protein affects the susceptibility to Morphine CTD PMID:16619846 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:75,943,064...75,967,696
JBrowse link
G Plcb1 phospholipase C beta 1 affects response to substance ISO PLCB1 protein affects the susceptibility to Morphine CTD PMID:16405873 NCBI chr 3:142,512,765...143,224,042
Ensembl chr 3:142,513,033...143,225,646
JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions
increases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in increased expression of PLCD1 protein] CTD PMID:23056601 NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:127,672,980...127,695,939
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression ISO Morphine results in decreased expression of PLCD4 mRNA CTD PMID:21955143 NCBI chr 9:83,564,616...83,613,742
Ensembl chr 9:83,564,606...83,606,454
JBrowse link
G Plekhg1 pleckstrin homology and RhoGEF domain containing G1 decreases expression ISO Morphine results in decreased expression of PLEKHG1 mRNA CTD PMID:21955143 NCBI chr 1:42,612,023...42,841,727
Ensembl chr 1:42,612,122...42,841,719
JBrowse link
G Plg plasminogen affects response to substance ISO PLG protein affects the susceptibility to Morphine CTD PMID:16619846 NCBI chr 1:50,872,927...50,915,406
Ensembl chr 1:50,872,926...50,917,320
JBrowse link
G Pllp plasmolipin decreases expression ISO Morphine results in decreased expression of PLLP mRNA CTD PMID:21955143 NCBI chr19:10,321,080...10,341,869
Ensembl chr19:10,321,080...10,342,226
JBrowse link
G Pnoc prepronociceptin decreases response to substance
increases expression
ISO
EXP
PNOC protein results in decreased susceptibility to Morphine
morphine increases expression of Pnoc protein in brain
CTD
RGD
PMID:17303110 PMID:10224316 PMID:11498977 RGD:616926596, RGD:616926595 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:43,800,246...43,827,470
JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 increases expression ISO Morphine results in increased expression of PNPLA3 mRNA CTD PMID:20144693 NCBI chr 7:117,173,485...117,194,065
Ensembl chr 7:117,173,516...117,194,594
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases expression
ISO
EXP
[Fentanyl co-treated with Morphine] results in decreased expression of POMC protein alternative form
Morphine deficiency results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
[Zymosan co-treated with Morphine] results in increased expression of POMC mRNA
Morphine results in increased expression of POMC mRNA
CTD PMID:2846107 PMID:15979727 PMID:20084599 PMID:20144693 PMID:24398105 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
G Ppia peptidylprolyl isomerase A increases expression EXP Morphine results in increased expression of PPIA protein CTD PMID:23056601 NCBI chr14:85,491,223...85,496,884
Ensembl chr14:85,492,484...85,497,115
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B affects expression
multiple interactions
increases phosphorylation
EXP
ISO
Morphine affects the expression of PPP1R1B protein modified form
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
ARL6IP5 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]; OPRD1 mutant form inhibits the reaction [Morphine results in increased phosphorylation of PPP1R1B protein]
CTD PMID:15287884 PMID:21600884 NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,844,036...83,853,063
JBrowse link
G Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha increases expression ISO Morphine deficiency results in increased expression of PPP3R1 mRNA; Morphine results in increased expression of PPP3R1 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr14:95,758,333...95,808,015 JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCA protein] CTD PMID:18652891 NCBI chr10:93,388,991...93,787,617
Ensembl chr10:93,388,991...93,787,572
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCB protein] CTD PMID:18652891 NCBI chr 1:186,263,397...186,594,743
Ensembl chr 1:186,263,447...186,594,740
JBrowse link
G Prkcd protein kinase C, delta decreases expression ISO Morphine results in decreased expression of PRKCD mRNA CTD PMID:21955143 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
increases expression
EXP
ISO
PENK protein alternative form inhibits the reaction [Morphine results in increased expression of PRKCG protein]
Dizocilpine Maleate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; HINT1 gene mutant form inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]
Morphine results in increased expression of PRKCG protein modified form
CTD PMID:18652891 PMID:20359526 PMID:20568289 PMID:21235400 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions EXP Morphine inhibits the reaction [Formaldehyde results in increased expression of PRKG1 protein] CTD PMID:12620371 NCBI chr 1:237,818,950...239,052,184
Ensembl chr 1:237,823,053...239,103,005
JBrowse link
G Prl prolactin increases secretion EXP Morphine results in increased secretion of PRL protein CTD PMID:7201058 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Prr18 proline rich 18 decreases expression ISO Morphine results in decreased expression of PRR18 mRNA CTD PMID:21955143 NCBI chr 1:52,400,215...52,403,998
Ensembl chr 1:54,947,351...54,959,997
JBrowse link
G Psma5 proteasome 20S subunit alpha 5 increases expression EXP Morphine results in increased expression of PSMA5 protein CTD PMID:23056601 NCBI chr 2:195,896,369...195,919,733
Ensembl chr 2:198,584,505...198,607,867
JBrowse link
G Psmd2 proteasome 26S subunit ubiquitin receptor, non-ATPase 2 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine results in decreased expression of PSMD2 protein] CTD PMID:23056601 NCBI chr11:80,248,364...80,258,991
Ensembl chr11:93,752,763...93,763,388
JBrowse link
G Ptdss2 phosphatidylserine synthase 2 increases expression ISO Morphine results in increased expression of PTDSS2 mRNA CTD PMID:20144693 NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:205,671,041...205,695,553
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
increases expression
multiple interactions
EXP Morphine results in decreased expression of PTGS1 mRNA
Morphine results in increased expression of PTGS1 mRNA
Minocycline inhibits the reaction [Morphine results in increased expression of PTGS1 mRNA]
CTD PMID:15183518 PMID:18706994 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
ISO
EXP
Morphine results in increased expression of PTGS2 protein
[nimesulide results in decreased activity of PTGS2 protein] which results in increased susceptibility to Morphine
[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha; [Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone; corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; Minocycline inhibits the reaction [Morphine results in increased expression of PTGS2 protein]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; S-methylisothiopseudouronium inhibits the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]
CTD PMID:14511336 PMID:16325209 PMID:37394652 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases phosphorylation EXP morphine decreases phosphorylation of Ptk2 in rat ventral tegmental area neurons RGD PMID:24399412 RGD:401959321 NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:107,015,733...107,172,091
JBrowse link
G Pvalb parvalbumin decreases expression ISO Morphine results in decreased expression of PVALB mRNA CTD PMID:21955143 NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:111,653,111...111,668,446
JBrowse link
G Pycard PYD and CARD domain containing decreases expression
increases expression
multiple interactions
ISO Morphine results in decreased expression of PYCARD mRNA
Morphine results in increased expression of PYCARD protein
corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]; Minocycline inhibits the reaction [Morphine results in increased expression of PYCARD protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]
CTD PMID:20144693 PMID:37394652 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
JBrowse link
G Pyy peptide YY increases expression ISO Morphine results in increased expression of PYY mRNA CTD PMID:20144693 NCBI chr10:87,561,347...87,562,470
Ensembl chr10:87,561,353...87,562,206
JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression ISO Morphine results in increased expression of RAB11B mRNA CTD PMID:21178816 NCBI chr 7:15,223,613...15,236,754
Ensembl chr 7:15,223,534...15,236,756
JBrowse link
G Rab3a RAB3A, member RAS oncogene family affects expression ISO Morphine affects the expression of RAB3A protein CTD PMID:16522322 NCBI chr16:18,718,164...18,722,273
Ensembl chr16:18,718,167...18,721,842
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase affects response to substance
multiple interactions
EXP
ISO
RAF1 protein affects the susceptibility to Morphine
HINT1 affects the reaction [Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]]; Morphine promotes the reaction [OPRM1 protein binds to RAF1 protein]
CTD PMID:18976650 PMID:21235400 NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:150,352,160...150,412,813
JBrowse link
G Ramp3 receptor activity modifying protein 3 decreases expression ISO Morphine results in decreased expression of RAMP3 mRNA CTD PMID:21955143 NCBI chr14:81,527,404...81,544,905
Ensembl chr14:85,755,211...85,758,818
JBrowse link
G Rbbp5 RB binding protein 5, histone lysine methyltransferase complex subunit decreases expression ISO Morphine results in decreased expression of RBBP5 mRNA CTD PMID:33891991 NCBI chr13:46,464,389...46,494,244
Ensembl chr13:46,464,389...46,491,238
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation
ISO
EXP
Morphine inhibits the reaction [Doxorubicin affects the localization of RELA protein]
Colforsin inhibits the reaction [Morphine results in increased phosphorylation of RELA protein]
CTD PMID:17542780 PMID:22258905 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
JBrowse link
G Reln reelin decreases expression ISO Morphine results in decreased expression of RELN mRNA CTD PMID:21178816 NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:13,628,399...14,055,162
JBrowse link
G Rem2 RRAD and GEM like GTPase 2 increases expression ISO Morphine results in increased expression of REM2 mRNA CTD PMID:21955143 NCBI chr15:31,903,972...31,908,451
Ensembl chr15:31,903,965...31,908,445
JBrowse link
G Rgs11 regulator of G-protein signaling 11 decreases expression
multiple interactions
ISO morphine decreases expression of Rgs11 mRNA in cortex
naloxone cotreated with morphine decreases expression of Rgs11 mRNA in brain
RGD PMID:15199376 PMID:15199376 RGD:597830059, RGD:597830059 NCBI chr10:15,222,804...15,231,062
Ensembl chr10:15,727,279...15,735,536
JBrowse link
G Rgs17 regulator of G-protein signaling 17 multiple interactions ISO Morphine promotes the reaction [GNAI2 protein binds to RGS17 protein]; Morphine promotes the reaction [GNAZ protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr 1:44,627,583...44,729,957
Ensembl chr 1:44,632,964...44,729,945
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression
increases expression
EXP Morphine results in decreased expression of RGS4 mRNA
Morphine results in increased expression of RGS4 mRNA
CTD PMID:12270694 NCBI chr13:84,469,593...84,475,884
Ensembl chr13:84,469,593...84,475,884
JBrowse link
G Rgs6 regulator of G-protein signaling 6 increases expression
multiple interactions
decreases expression
ISO Morphine results in increased expression of RGS6 mRNA
naloxone cotreated with morphine decreases expression of Rgs6 mRNA in central gray substance of midbrain and striatum
CTD
RGD
PMID:21178816 PMID:15199376 PMID:15199376 RGD:597830059, RGD:597830059 NCBI chr 6:102,264,451...102,796,311
Ensembl chr 6:107,876,039...108,555,840
JBrowse link
G Rgs7 regulator of G-protein signaling 7 increases expression
multiple interactions
ISO Morphine increases expression of Rgs7 mRNA in brain.
morphine co-treated with naloxone increases expression of Rgs7 mRNA in brain
RGD PMID:15199376 PMID:15199376 RGD:597830059, RGD:597830059 NCBI chr13:86,979,269...87,408,834
Ensembl chr13:89,511,150...89,940,987
JBrowse link
G Ring1 ring finger protein 1 multiple interactions EXP Morphine inhibits the reaction [RING1 protein alternative form binds to BDNF promoter] CTD PMID:25643298 NCBI chr20:4,832,013...4,835,516
Ensembl chr20:4,831,993...4,835,513
JBrowse link
G Rph3a rabphilin 3A decreases expression ISO Morphine results in decreased expression of RPH3A mRNA CTD PMID:21955143 NCBI chr12:35,542,389...35,618,901
Ensembl chr12:41,200,089...41,279,531
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO Morphine results in increased expression of RRM2B mRNA CTD PMID:21178816 NCBI chr 7:70,962,008...70,993,726
Ensembl chr 7:70,965,590...70,993,670
JBrowse link
G S100b S100 calcium binding protein B decreases expression ISO Morphine results in decreased expression of S100B mRNA CTD PMID:21955143 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081
JBrowse link
G Sdc4 syndecan 4 increases expression ISO Morphine deficiency results in increased expression of SDC4 mRNA; Morphine results in increased expression of SDC4 mRNA CTD PMID:21955143 PMID:27126842 NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:173,574,239...173,593,670
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine results in increased expression of SDHA protein] CTD PMID:23056601 NCBI chr 1:30,764,553...30,789,523
Ensembl chr 1:30,764,590...30,790,121
JBrowse link
G Sell selectin L decreases expression
multiple interactions
EXP Morphine results in decreased expression of SELL protein alternative form
Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]; phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form]
CTD PMID:10070497 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600
JBrowse link
G Septin7 septin 7 multiple interactions
decreases expression
EXP Morphine deficiency inhibits the reaction [Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein]]; Morphine deficiency inhibits the reaction [Morphine results in decreased expression of SEPTIN7 protein] CTD PMID:23056601 NCBI chr 8:31,995,597...32,059,069
Ensembl chr 8:31,995,005...32,059,072
JBrowse link
G Septin8 septin 8 decreases expression ISO Morphine results in decreased expression of SEPTIN8 mRNA CTD PMID:21955143 NCBI chr10:38,185,454...38,214,502
Ensembl chr10:38,185,335...38,214,504
JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO Morphine results in decreased expression of SERPINB1A mRNA CTD PMID:21955143 NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,799,415...31,808,166
JBrowse link
G Serpinf1 serpin family F member 1 decreases expression ISO Morphine results in decreased expression of SERPINF1 mRNA CTD PMID:21955143 NCBI chr10:60,748,504...60,760,898
Ensembl chr10:60,748,506...60,760,898
JBrowse link
G Serping1 serpin family G member 1 multiple interactions
decreases expression
EXP Morphine deficiency affects the reaction [Morphine results in decreased expression of SERPING1 protein] CTD PMID:23056601 NCBI chr 3:90,249,410...90,259,299
Ensembl chr 3:90,249,423...90,258,717
JBrowse link
G Sertad4 SERTA domain containing 4 increases expression ISO Morphine results in increased expression of SERTAD4 mRNA CTD PMID:21955143 NCBI chr13:104,360,307...104,371,064
Ensembl chr13:106,889,019...106,900,309
JBrowse link
G Setd1a SET domain containing 1A, histone lysine methyltransferase affects expression ISO Morphine affects the expression of SETD1A mRNA CTD PMID:33891991 NCBI chr 1:191,818,752...191,842,167
Ensembl chr 1:191,818,752...191,842,160
JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase affects expression ISO Morphine affects the expression of SETD1B mRNA CTD PMID:33891991 NCBI chr12:39,056,809...39,082,399
Ensembl chr12:39,058,262...39,082,566
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression ISO Morphine results in increased expression of SGK1 mRNA CTD PMID:21955143 NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:24,799,396...24,807,231
JBrowse link
G Shox2 SHOX homeobox 2 decreases expression ISO Morphine results in decreased expression of SHOX2 mRNA CTD PMID:21955143 NCBI chr 2:153,524,324...153,537,571
Ensembl chr 2:153,527,571...153,537,161
JBrowse link
G Sin3a SIN3 transcription regulator family member A multiple interactions EXP Morphine promotes the reaction [SIN3A protein binds to BDNF promoter] CTD PMID:25643298 NCBI chr 8:66,377,471...66,432,150
Ensembl chr 8:66,381,657...66,434,542
JBrowse link
G Slc17a6 solute carrier family 17 member 6 decreases expression ISO Morphine results in decreased expression of SLC17A6 mRNA CTD PMID:21955143 NCBI chr 1:110,348,447...110,388,499
Ensembl chr 1:110,348,447...110,388,498
JBrowse link
G Slc17a7 solute carrier family 17 member 7 affects expression ISO Morphine affects the expression of SLC17A7 protein CTD PMID:16522322 NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:104,785,955...104,798,049
JBrowse link
G Slc1a2 solute carrier family 1 member 2 decreases expression EXP morphine decreases expression of GLT-1 protein in cultured astrocytes RGD PMID:28341892 RGD:597978120 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249
JBrowse link
G Slc23a2 solute carrier family 23 member 2 decreases expression EXP Morphine results in decreased expression of SLC23A2 mRNA CTD PMID:19418264 NCBI chr 3:139,755,583...139,913,304
Ensembl chr 3:139,755,584...139,847,343
JBrowse link
G Slc25a46 solute carrier family 25, member 46 multiple interactions
decreases expression
EXP Morphine deficiency promotes the reaction [Morphine results in decreased expression of SLC25A46 protein] CTD PMID:23056601 NCBI chr18:23,215,954...23,244,917
Ensembl chr18:23,490,425...23,518,730
JBrowse link
G Slc6a1 solute carrier family 6 member 1 multiple interactions
affects response to substance
ISO [NNC 711 results in decreased activity of SLC6A1 protein] which affects the susceptibility to Morphine
SLC6A1 protein affects the susceptibility to Morphine
CTD PMID:14598306 NCBI chr 4:149,004,447...149,037,840
Ensembl chr 4:149,004,635...149,037,839
JBrowse link
G Slc6a18 solute carrier family 6 member 18 increases expression ISO Morphine results in increased expression of SLC6A18 mRNA CTD PMID:20144693 NCBI chr 1:31,436,577...31,450,478
Ensembl chr 1:31,436,630...31,450,478
JBrowse link
G Slc6a7 solute carrier family 6 member 7 decreases expression ISO Morphine results in decreased expression of SLC6A7 mRNA CTD PMID:21955143 NCBI chr18:56,718,849...56,737,702
Ensembl chr18:56,718,849...56,737,702
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
increases expression
ISO Morphine affects the reaction [SMPD1 protein affects the abundance of Ceramides]; Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein] CTD PMID:22825003 NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614
JBrowse link
G Smpx small muscle protein, X-linked increases expression
multiple interactions
EXP Morphine results in increased expression of SMPX protein
Morphine deficiency affects the reaction [Morphine results in increased expression of SMPX protein]
CTD PMID:23056601 NCBI chr  X:41,049,354...41,107,323
Ensembl chr  X:41,049,356...41,107,137
JBrowse link
G Snca synuclein alpha increases expression EXP Morphine results in increased expression of SNCA mRNA CTD PMID:15183518 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO Morphine results in increased expression of SOD2 protein
Saquinavir inhibits the reaction [Morphine results in increased expression of SOD2 protein]
CTD PMID:14871405 PMID:20564181 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Sowaha sosondowah ankyrin repeat domain family member A increases expression ISO Morphine results in increased expression of SOWAHA mRNA CTD PMID:21955143 NCBI chr10:37,641,823...37,645,390
Ensembl chr10:38,144,782...38,147,171
JBrowse link
G Srf serum response factor increases expression EXP Morphine results in increased expression of SRF mRNA CTD PMID:22454534 NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:21,924,076...21,933,337
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Morphine results in increased expression of SRXN1 mRNA CTD PMID:20144693 NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:161,059,931...161,088,765
JBrowse link
G Sst somatostatin increases expression ISO Morphine results in increased expression of SST mRNA CTD PMID:21178816 NCBI chr11:90,461,546...90,462,823
Ensembl chr11:90,461,546...90,462,823
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 increases expression
decreases expression
ISO Morphine results in increased expression of ST8SIA3 mRNA
Morphine deficiency results in decreased expression of ST8SIA3 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr18:57,754,349...57,760,839
Ensembl chr18:60,024,236...60,032,473
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Morphine results in increased phosphorylation of STAT3 protein CTD PMID:18385270 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
G Stat6 signal transducer and activator of transcription 6 affects response to substance ISO STAT6 gene SNP affects the susceptibility to Morphine CTD PMID:16103897 NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:65,365,306...65,383,795
JBrowse link
G Strip2 striatin interacting protein 2 increases expression
decreases expression
ISO Morphine results in increased expression of STRIP2 mRNA
Morphine deficiency results in decreased expression of STRIP2 mRNA
CTD PMID:21955143 PMID:27126842 NCBI chr 4:58,536,034...58,578,279
Ensembl chr 4:59,503,481...59,545,739
JBrowse link
G Stx12 syntaxin 12 increases expression EXP Morphine results in increased expression of STX12 mRNA CTD PMID:15183518 NCBI chr 5:150,347,554...150,376,426
Ensembl chr 5:150,334,836...150,376,346
JBrowse link
G Stx5 syntaxin 5 increases expression EXP Morphine results in increased expression of STX5A mRNA CTD PMID:15183518 NCBI chr 1:205,637,401...205,653,563
Ensembl chr 1:215,067,317...215,082,683
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha decreases expression EXP Morphine results in decreased expression of SUCLG1 protein CTD PMID:23056601 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:106,866,114...106,895,689
JBrowse link
G Suz12 SUZ12 polycomb repressive complex 2 subunit multiple interactions
increases expression
EXP
ISO
Morphine promotes the reaction [SUZ12 protein binds to BDNF promoter]
Morphine results in increased expression of SUZ12 mRNA
CTD PMID:25643298 PMID:33891991 NCBI chr10:65,464,948...65,510,846
Ensembl chr10:65,464,969...65,510,846
JBrowse link
G Syne1 spectrin repeat containing nuclear envelope protein 1 increases expression ISO Morphine results in increased expression of SYNE1 mRNA CTD PMID:21955143 NCBI chr 1:43,917,640...44,388,802
Ensembl chr 1:43,895,994...44,388,721
JBrowse link
G Syt5 synaptotagmin 5 increases expression ISO Morphine results in increased expression of SYT5 mRNA CTD PMID:21178816 NCBI chr 1:78,320,034...78,327,750
Ensembl chr 1:78,320,034...78,327,746
JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO Morphine results in decreased expression of SYT9 mRNA CTD PMID:21955143 NCBI chr 1:170,687,666...170,868,146
Ensembl chr 1:170,687,606...170,881,375
JBrowse link
G Tac1 tachykinin, precursor 1 increases expression
multiple interactions
ISO
EXP
Morphine deficiency results in increased expression of TAC1 mRNA; Morphine results in increased expression of TAC1 mRNA
Morphine results in increased expression of TAC1 protein
Morphine promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein]
CTD PMID:11976266 PMID:15964684 PMID:21178816 PMID:27126842 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions
decreases expression
increases expression
EXP [SR 140333 binds to and results in decreased activity of TACR1 protein] which results in increased susceptibility to Morphine; substance P-saporin inhibits the reaction [Morphine results in increased expression of TACR1 protein]
Morphine results in decreased expression of TACR1 protein
CTD PMID:14511336 PMID:15964684 PMID:17123731 PMID:19428329 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:116,478,617...116,647,492
JBrowse link
G Tacr2 tachykinin receptor 2 decreases expression EXP Morphine results in decreased expression of TACR2 protein CTD PMID:19428329 NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,751,557...30,766,180
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 decreases expression ISO Morphine results in decreased expression of TET1 mRNA CTD PMID:33891991 NCBI chr20:25,766,806...25,839,598
Ensembl chr20:25,760,057...25,832,730
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 affects expression ISO Morphine affects the expression of TET2 mRNA CTD PMID:33891991 NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:224,662,654...224,746,186
JBrowse link
G Tet3 tet methylcytosine dioxygenase 3 affects expression ISO Morphine affects the expression of TET3 mRNA CTD PMID:33891991 NCBI chr 4:117,425,106...117,525,495
Ensembl chr 4:117,429,857...117,520,486
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Morphine results in increased expression of and results in increased localization of TGFB1 protein; TGFB1 protein affects the reaction [Morphine results in increased expression of and results in increased localization of TGFB1 protein]; TGFB1 protein affects the reaction [Morphine results in increased expression of BAX protein] CTD PMID:10809959 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
JBrowse link
G Th tyrosine hydroxylase increases expression
multiple interactions
decreases expression
increases phosphorylation
EXP
ISO
Morphine results in increased expression of TH protein
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Morphine deficiency results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; Agmatine inhibits the reaction [Morphine results in increased expression of TH protein]; Morphine promotes the reaction [CREB1 protein modified form binds to TH promoter]
Morphine results in decreased expression of TH protein
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:15541421 PMID:24398105 PMID:25308750 PMID:25582704 PMID:25643298 More... NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Tkt transketolase decreases expression EXP Morphine results in decreased expression of TKT protein CTD PMID:23056601 NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,729,991...5,756,431
JBrowse link
G Tlr2 toll-like receptor 2 increases expression
multiple interactions
ISO Morphine results in increased expression of TLR2 mRNA; Morphine results in increased expression of TLR2 protein
corilagin inhibits the reaction [Morphine results in increased expression of TLR2 mRNA]; corilagin inhibits the reaction [Morphine results in increased expression of TLR2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased cleavage of CASP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of AIF1 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of ATF4 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of DDIT3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of HSPA5 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL1B protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of IL6 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NLRP3 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PTGS2 protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of PYCARD protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased phosphorylation of EIF2AK3 protein]]
CTD PMID:37394652 PMID:37981055 NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:171,497,060...171,520,194
JBrowse link
G Tlr4 toll-like receptor 4 affects binding
increases expression
multiple interactions
affects response to substance
ISO
EXP
Morphine binds to TLR4 protein
Morphine results in increased expression of TLR4 protein
dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]]; Resveratrol inhibits the reaction [Morphine results in increased expression of TLR4 protein]
Morphine affects the susceptibility to TLR4 protein
Naloxone affects the reaction [Morphine binds to TLR4 protein]
CTD PMID:20178837 PMID:24756886 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tmcc3 transmembrane and coiled-coil domain family 3 decreases expression ISO Morphine results in decreased expression of TMCC3 mRNA CTD PMID:21955143 NCBI chr 7:28,893,972...29,171,935
Ensembl chr 7:30,897,991...31,058,889
JBrowse link
G Tmem125 transmembrane protein 125 decreases expression ISO Morphine results in decreased expression of TMEM125 mRNA CTD PMID:21955143 NCBI chr 5:132,063,162...132,064,566
Ensembl chr 5:137,345,202...137,351,952
JBrowse link
G Tmem163 transmembrane protein 163 decreases expression ISO Morphine results in decreased expression of TMEM163 mRNA CTD PMID:21955143 NCBI chr13:41,520,595...41,693,938
Ensembl chr13:41,520,359...41,693,938
JBrowse link
G Tmem63a transmembrane protein 63a decreases expression ISO Morphine results in decreased expression of TMEM63A mRNA CTD PMID:21955143 NCBI chr13:95,194,323...95,227,944
Ensembl chr13:95,195,234...95,228,302
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases secretion
EXP
ISO
Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of TNF mRNA]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [Morphine results in increased expression of TNF protein]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]; Resveratrol inhibits the reaction [Morphine results in increased expression of TNF mRNA]
corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of TNF protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of TNF protein]; Resveratrol inhibits the reaction [Morphine results in increased expression of TNF protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of TNF protein]]
Calcium affects the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; CTAP octapeptide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]]; Cycloheximide inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]]; Morphine inhibits the reaction [TNF protein results in increased expression of CNR1 mRNA]; Morphine inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Morphine inhibits the reaction [TNF protein results in increased ubiquitination of and results in increased degradation of NFKBIA protein]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
Morphine results in increased expression of TNF mRNA; Morphine results in increased expression of TNF protein
Morphine results in increased secretion of TNF protein
CTD PMID:12427855 PMID:15317861 PMID:20178837 PMID:21081778 PMID:22258905 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO Morphine results in increased expression of TNFSF10 mRNA CTD PMID:16210602 NCBI chr 2:112,136,550...112,155,903 JBrowse link
G Tomm70 translocase of outer mitochondrial membrane 70 decreases expression ISO Morphine results in decreased expression of TOMM70A mRNA CTD PMID:21955143 NCBI chr11:56,847,837...56,886,302
Ensembl chr11:56,846,334...56,886,320
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BAX protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of CDKN1A protein; [Morphine results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of FAS protein; Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]; Morphine results in increased phosphorylation of and results in increased activity of TP53 protein; Morphine results in increased phosphorylation of and results in increased stability of TP53 protein; Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]; Naloxone inhibits the reaction [Morphine results in increased expression of TP53]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein]
Morphine results in increased expression of TP53 mRNA
CTD PMID:12702572 PMID:12927789 PMID:19397953 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Trdmt1 tRNA aspartic acid methyltransferase 1 affects expression ISO Morphine affects the expression of TRDMT1 mRNA CTD PMID:33891991 NCBI chr17:81,510,740...81,554,036
Ensembl chr17:81,521,200...81,577,639
JBrowse link
G Trh thyrotropin releasing hormone increases expression ISO Morphine results in increased expression of TRH mRNA CTD PMID:21178816 NCBI chr 4:126,299,236...126,301,762
Ensembl chr 4:126,299,236...126,301,762
JBrowse link
G Trhr thyrotropin releasing hormone receptor increases expression ISO Morphine results in increased expression of TRHR mRNA CTD PMID:21178816 NCBI chr 7:75,348,672...75,393,310
Ensembl chr 7:77,233,354...77,277,987
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions
affects activity
increases expression
affects response to substance
ISO
EXP
[N-(7-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl)-3-(2-(piperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)acrylamide binds to and results in decreased activity of TRPV1 protein] which results in decreased susceptibility to Morphine
Morphine affects the activity of TRPV1 protein
Morphine results in increased expression of TRPV1; Morphine results in increased expression of TRPV1 protein
TRPV1 protein affects the susceptibility to Morphine
CTD PMID:18774343 PMID:20719804 PMID:22189556 NCBI chr10:58,349,936...58,375,021
Ensembl chr10:58,340,223...58,375,021
JBrowse link
G Ttll11 tubulin tyrosine ligase like 11 increases expression ISO Morphine results in increased expression of TTLL11 mRNA CTD PMID:21178816 NCBI chr 3:19,109,891...19,335,077
Ensembl chr 3:39,507,723...39,732,708
JBrowse link
G Ttr transthyretin decreases expression
multiple interactions
EXP Morphine results in decreased expression of TTR protein
Morphine deficiency affects the reaction [Morphine results in decreased expression of TTR protein]
CTD PMID:23056601 NCBI chr18:12,216,684...12,225,972
Ensembl chr18:12,216,732...12,225,969
JBrowse link
G Tubb4a tubulin, beta 4A class IVa decreases expression ISO Morphine results in decreased expression of TUBB4A mRNA CTD PMID:21955143 NCBI chr 9:1,917,841...1,925,286
Ensembl chr 9:2,004,840...2,012,286
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO Morphine results in increased expression of UGT1A5 mRNA CTD PMID:21955143 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases glucuronidation ISO UGT1A6 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Morphine CTD PMID:12920162 NCBI chr 9:96,144,786...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects metabolic processing
increases glucuronidation
ISO UGT2B7 affects the metabolism of Morphine; UGT2B7 protein affects the metabolism of Morphine
UGT2B7 protein results in increased glucuronidation of Morphine
CTD PMID:11186130 PMID:12756209 PMID:12920162 PMID:15286053 PMID:15611481 More... NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451
JBrowse link
G Usp15 ubiquitin specific peptidase 15 multiple interactions
increases expression
ISO Calcium affects the reaction [Morphine results in increased expression of USP15 mRNA]; CTAP octapeptide inhibits the reaction [Morphine results in increased expression of USP15 mRNA]; USP15 mutant form inhibits the reaction [Morphine inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]]
Morphine results in increased expression of USP15 mRNA; Morphine results in increased expression of USP15 protein
CTD PMID:24068670 NCBI chr 7:60,643,611...60,805,137
Ensembl chr 7:60,643,613...60,734,099
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Morphine results in increased expression of VEGFA protein CTD PMID:19356684 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
JBrowse link
G Vim vimentin multiple interactions
increases expression
EXP Morphine deficiency affects the reaction [Morphine results in increased expression of VIM protein] CTD PMID:23056601 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon decreases expression EXP Morphine results in decreased expression of YWHAE protein CTD PMID:23056601 NCBI chr10:61,082,934...61,120,618
Ensembl chr10:61,106,716...61,114,291
JBrowse link
G Zfp239 zinc finger protein 239 increases expression ISO Morphine results in increased expression of ZFP239 mRNA CTD PMID:21178816 NCBI chr 4:151,029,431...151,039,283
Ensembl chr 4:152,693,531...152,714,903
JBrowse link
G Zic1 Zic family member 1 increases expression ISO Morphine results in increased expression of ZIC1 mRNA CTD PMID:21955143 NCBI chr 8:91,908,548...91,918,020
Ensembl chr 8:100,787,789...100,792,427
JBrowse link
morphine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cartpt CART prepropeptide decreases expression EXP morphine hydrochloride decreases expression of Cartpt mRNA in hippocampus RGD PMID:32198124 RGD:407571681 NCBI chr 2:32,989,215...32,991,794
Ensembl chr 2:32,989,215...32,999,712
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression EXP Morphine hydrochloride increases expression of Ppargc1a mRNA in hippocampus RGD PMID:32198124 RGD:407571681 NCBI chr14:63,073,505...63,729,215
Ensembl chr14:63,273,189...63,729,213
JBrowse link
morphinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO morphinone results in increased activity of CASP3 protein CTD PMID:17094451 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
N-desmethylclozapine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases chemical synthesis ISO CYP1A1 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases chemical synthesis
increases metabolic processing
ISO [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of norclozapine; Fluvoxamine inhibits the reaction [CYP1A2 protein results in increased chemical synthesis of norclozapine]
CYP1A2 protein results in increased metabolism of norclozapine
CTD PMID:11151749 PMID:12969762 PMID:18809730 NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:66,971,261...66,978,149
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases chemical synthesis ISO CYP1B1 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:21,078,146...21,103,142
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases chemical synthesis ISO CYP2C19 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:247,879,078...247,916,798
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases chemical synthesis ISO CYP2C8 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases chemical synthesis ISO CYP2D6 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases chemical synthesis ISO CYP2J2 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions
ISO CYP3A4 protein results in increased chemical synthesis of norclozapine
Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of norclozapine]
CTD PMID:18809730 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis ISO CYP3A5 protein results in increased chemical synthesis of norclozapine CTD PMID:18809730 NCBI chr12:21,919,955...21,960,160
Ensembl chr12:21,919,940...21,960,154
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases expression ISO
EXP
norclozapine results in decreased expression of HTR2A mRNA
norclozapine results in decreased expression of HTR2A protein
CTD PMID:14751426 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
JBrowse link
nalbuphine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin increases expression ISO Nalbuphine results in increased expression of PRL protein CTD PMID:17391744 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nalbuphine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:50,668,817...50,711,019
JBrowse link
nalbuphine hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prl prolactin affects expression ISO nalbuphine hydrochloride affects expression of PRL in blood serum RGD PMID:17391744 RGD:401960113 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
naloxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
multiple interactions
EXP Naloxone results in increased expression of ABCB1 mRNA
[Morphine co-treated with Naloxone] results in increased expression of ABCB1A mRNA
CTD PMID:17522070 PMID:26554626 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Naloxone results in increased expression of ABCC3 mRNA CTD PMID:17522070 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,793,583...79,839,494
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions EXP [Morphine co-treated with Naloxone] results in increased expression of ABCG2 mRNA CTD PMID:26554626 NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:89,005,969...89,132,493
JBrowse link
G Acly ATP citrate lyase decreases expression EXP Naloxone results in decreased expression of ACLY mRNA CTD PMID:17522070 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Naloxone inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein] CTD PMID:17989109 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions EXP naloxone co-treated with morphine increases expression of Adra2a mRNA in cerebral cortex RGD PMID:9105684 RGD:401976538 NCBI chr 1:263,066,780...263,069,580
Ensembl chr 1:263,065,278...263,069,871
JBrowse link
G Agt angiotensinogen multiple interactions EXP Naloxone promotes the reaction [AGT protein results in increased expression of CRH protein]; Naloxone promotes the reaction [AGT protein results in increased expression of FOS protein]; Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein] CTD PMID:33872574 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:69,421,638...69,446,944
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of AKT1 protein modified form] CTD PMID:20600172 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 decreases expression EXP Naloxone results in decreased expression of APEX1 mRNA CTD PMID:17522070 NCBI chr15:26,618,146...26,620,330
Ensembl chr15:26,618,224...26,620,329
JBrowse link
G Aqp4 aquaporin 4 multiple interactions EXP [naloxone cotreatment with morphine] inhibits the reaction [morphine decreases expression of AQP4 protein in cultured astrocytes] RGD PMID:28341892 RGD:597978120 NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,782,389...6,799,098
JBrowse link
G Arc activity-regulated cytoskeleton-associated protein increases expression EXP naloxene co-treated with morphine increases expression of Arc protein in brain RGD PMID:19262551 RGD:401938601 NCBI chr 7:108,444,959...108,448,413
Ensembl chr 7:108,444,692...108,451,220
JBrowse link
G Avp arginine vasopressin decreases secretion
decreases expression
increases expression
ISO
EXP
Naloxone results in decreased secretion of AVP protein
Naloxone decreases expression of Avp mRNA in the hypothalamus
Naloxone increases expression of Avp mRNA in paraventricular nucleus of hypothalamus
CTD
RGD
PMID:6850280 PMID:23805290 PMID:21677651 RGD:407572522, RGD:408418732 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:138,246,554...138,248,522
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of BAX protein]] CTD PMID:12927789 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in decreased expression of BCL2 protein]]
Naloxone results in increased expression of BCL2 protein
CTD PMID:12927789 PMID:16004788 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
JBrowse link
G Calca calcitonin-related polypeptide alpha affects activity
multiple interactions
EXP Naloxone affects the activity of CALCA protein
Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]; Naloxone inhibits the reaction [Fentanyl inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]]
CTD PMID:7906887 PMID:10075105 PMID:27030709 NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:178,312,638...178,317,529
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased activity of CASP3 protein]; Naloxone inhibits the reaction [Morphine results in increased expression of CASP3 protein alternative form] CTD PMID:20600172 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase increases expression EXP Naloxone results in increased expression of CAT mRNA CTD PMID:17522070 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cck cholecystokinin multiple interactions EXP Naloxone inhibits the reaction [CCK protein results in decreased activity of Apomorphine] CTD PMID:3561887 NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:130,031,013...130,037,686
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein] CTD PMID:17084265 NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,503,077...67,504,875
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased expression of CCL5 protein] CTD PMID:11106302 NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,738,651...68,824,884
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
affects binding
ISO CES1 protein binds to and results in increased metabolism of Naloxone
Naloxone binds to CES1 protein
CTD PMID:12679808 PMID:12773168 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449
JBrowse link
G Crh corticotropin releasing hormone decreases expression
multiple interactions
EXP Naloxone results in decreased expression of CRH mRNA
Naloxone promotes the reaction [AGT protein results in increased expression of CRH protein]
CTD PMID:12431775 PMID:33872574 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Crhr1 corticotropin releasing hormone receptor 1 multiple interactions
increases response to substance
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone affects the abundance of Norepinephrine]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [CP 154526 binds to and results in decreased activity of CRHR1 protein] which results in decreased susceptibility to Naloxone
CRHR1 gene mutant form results in increased susceptibility to Naloxone
CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25582704 PMID:28434951 NCBI chr10:89,540,192...89,583,466
Ensembl chr10:89,540,192...89,583,466
JBrowse link
G Ctsl cathepsin L increases expression EXP Naloxone results in increased expression of CTSL mRNA CTD PMID:17522070 NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113
JBrowse link
G Ddb2 damage specific DNA binding protein 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of DDB2] CTD PMID:19397953 NCBI chr 3:97,640,923...97,667,617
Ensembl chr 3:97,640,579...97,664,066
JBrowse link
G Drd4 dopamine receptor D4 multiple interactions ISO [3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine binds to and results in decreased activity of DRD4 protein] inhibits the reaction [Naloxone results in increased abundance of Cyclic AMP] CTD PMID:15542745 NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:205,826,049...205,830,458
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO Naloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein] CTD PMID:26377394 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
JBrowse link
G Fasn fatty acid synthase decreases expression EXP Naloxone results in decreased expression of FASN mRNA CTD PMID:17522070 NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,570,413...106,588,583
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in decreased secretion of FGF2 protein] CTD PMID:20564181 NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:122,164,454...122,224,493
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
[Morphine co-treated with Dizocilpine Maleate] inhibits the reaction [Naloxone results in increased expression of FOS protein]
1-(2-methylbenzoxazol-6-yl)-3-(1,5)naphthyridin-4-yl urea inhibits the reaction [[Morphine co-treated with Naloxone] results in increased expression of FOS protein]; [Morphine co-treated with Naloxone] results in increased expression of FOS protein; [Naloxone co-treated with Morphine] results in increased expression of FOS protein; Naloxone promotes the reaction [AGT protein results in increased expression of FOS protein]; Pentobarbital promotes the reaction [Naloxone results in increased expression of FOS protein]; SL 327 inhibits the reaction [Naloxone results in increased expression of FOS protein]
CTD PMID:9041360 PMID:15196794 PMID:16935424 PMID:17549049 PMID:22590628 More... NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Naloxene co-treated with morphine increases expression of Fosb protein in the Brainstem RGD PMID:20438612 RGD:401900159 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Naloxone results in increased expression of GADD45A mRNA CTD PMID:17522070 NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:97,484,502...97,486,807
JBrowse link
G Gal galanin and GMAP prepropeptide multiple interactions EXP naloxone inhibits the reaction [ethanol increases expression of Gal mRNA and protein in hypothalamic nuclei] RGD PMID:12818715 RGD:598148182 NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:210,079,702...210,084,229
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine increases localization of Gria1 protein on nucleus accumbens cell surface] RGD PMID:27225765 RGD:405650668 NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,711,080...42,030,309
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of GSK3B protein modified form] CTD PMID:20600172 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 decreases expression EXP Naloxone results in decreased expression of GSTM3 mRNA CTD PMID:17522070 NCBI chr 2:198,219,769...198,222,732
Ensembl chr 2:198,219,647...198,222,731
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of HSPA1A mRNA] CTD PMID:15497504 NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,855,780...3,877,979
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Naloxone results in increased expression of HSPA5 protein CTD PMID:26377394 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form] CTD PMID:10070497 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Naloxone inhibits the reaction [Carrageenan inhibits the reaction [Morphine results in decreased expression of IL1A protein]]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Carrageenan results in decreased expression of IL1A protein]] CTD PMID:12182845 NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:136,979,805...136,998,013
JBrowse link
G Il1b interleukin 1 beta increases response to substance ISO Naloxone results in increased susceptibility to IL1B protein CTD PMID:19458216 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases response to substance
ISO Freund's Adjuvant inhibits the reaction [Naloxone results in decreased susceptibility to IL2 protein] CTD PMID:12421473 NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:121,932,968...121,937,672
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
naloxone inhibits the reaction [methamphetamine increases expression of IL6 mRNA in ventral tegmental area]
CTD
RGD
PMID:17084265 PMID:31282647 RGD:598092520 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Itgam integrin subunit alpha M multiple interactions EXP naloxone inhibits the reaction [methamphetamine increases expression of Itgam mRNA in ventral tegmental area] RGD PMID:31282647 RGD:598092520 NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:192,089,542...192,139,943
JBrowse link
G Klf7 KLF transcription factor 7 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of KLF7 mRNA] CTD PMID:14644156 NCBI chr 9:72,927,485...73,020,167
Ensembl chr 9:72,933,136...73,020,056
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP Naloxone results in increased expression of LBP mRNA CTD PMID:17522070 NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:167,373,924...167,401,518
JBrowse link
G Lgals3 galectin 3 increases expression EXP Naloxone results in increased expression of LGALS3 mRNA CTD PMID:17522070 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
affects expression
multiple interactions
ISO
EXP
Naloxone results in increased expression of LHB protein
Naloxone affects the expression of LHB protein
Naloxone affects the expression of and affects the secretion of LHB protein
CTD PMID:1794335 PMID:2745936 PMID:2880862 PMID:7629406 PMID:15905218 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
JBrowse link
G Lipc lipase C, hepatic type decreases expression EXP Naloxone results in decreased expression of LIPC mRNA CTD PMID:17522070 NCBI chr 8:80,390,470...80,516,463
Ensembl chr 8:80,390,471...80,516,285
JBrowse link
G Ltf lactotransferrin decreases activity EXP Naloxone results in decreased activity of LTF protein CTD PMID:14563657 NCBI chr 8:119,878,344...119,901,189
Ensembl chr 8:119,878,344...119,901,189
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK1 protein]; Naloxone results in increased phosphorylation of and results in increased activity of MAPK1 protein
Naloxone results in increased phosphorylation of MAPK1 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:17549049 PMID:21483469 PMID:24398105 PMID:33872574 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
EXP
ISO
Naloxone promotes the reaction [AGT protein results in increased phosphorylation of MAPK3 protein]; Naloxone results in increased phosphorylation of and results in increased activity of MAPK3 protein
Naloxone results in increased phosphorylation of MAPK3 protein
Naloxone promotes the reaction [Morphine results in increased phosphorylation of and results in increased activity of MAPK3 protein]
CTD PMID:17549049 PMID:21483469 PMID:24398105 PMID:33872574 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Mir16-2 microRNA 16-2 increases expression EXP Naloxone results in increased expression of MIR16-2 mRNA CTD PMID:17522070 NCBI chr 2:155,555,327...155,555,421
Ensembl chr 2:155,555,327...155,555,421
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:149,806,826...149,957,381
Ensembl chr 2:149,872,291...149,953,463
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein]; [Morphine co-treated with Naloxone] results in increased activity of MMP9 protein CTD PMID:20519536 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
JBrowse link
G Mug1 murinoglobulin 1 decreases expression EXP Naloxone results in decreased expression of MUG1 mRNA CTD PMID:17522070 NCBI chr 4:156,748,351...156,802,132 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP Naloxone results in increased expression of MYC mRNA CTD PMID:17522070 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions ISO [7-nitroindazole results in decreased activity of NOS1 protein] inhibits the reaction [[Morphine co-treated with Naloxone] results in increased activity of MMP9 protein] CTD PMID:20519536 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837
JBrowse link
G Nppa natriuretic peptide A decreases expression ISO Naloxone results in decreased expression of NPPA protein CTD PMID:11311734 NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:163,712,184...163,713,493
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Naloxone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Naloxone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
ISO
EXP
[[Naloxone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]; Naloxone inhibits the reaction [Morphine inhibits the reaction [Tretinoin results in increased expression of OPRM1 mRNA]]
[naloxone cotreatment with morphine] inhibits the reaction [morphine decreases expression of Oprm1 protein in cultured astrocytes]
Naloxone inhibits the reaction [Morphine results in increased phosphorylation of OPRM1 protein]
Naloxone binds to OPRM1 protein
[Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Clonidine; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; [Naloxone binds to and results in decreased activity of OPRM1 protein] which results in decreased susceptibility to N(6)-cyclopentyladenosine; Cannabidiol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Dronabinol promotes the reaction [Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]]; Naloxone binds to and results in decreased activity of OPRM1 protein; Naloxone inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- binds to and results in increased activity of OPRM1 protein]
CTD
RGD
PMID:1528399 PMID:1654493 PMID:7562497 PMID:8383026 PMID:8987795 More... RGD:597978120 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Otc ornithine transcarbamylase decreases expression EXP Naloxone results in decreased expression of OTC mRNA CTD PMID:17522070 NCBI chr  X:15,126,358...15,202,473
Ensembl chr  X:15,126,358...15,239,555
JBrowse link
G Pklr pyruvate kinase L/R decreases expression EXP Naloxone results in decreased expression of PKLR mRNA CTD PMID:17522070 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644
JBrowse link
G Pnoc prepronociceptin decreases expression EXP naloxone decreased expression of Pnoc protein in frontal cortex and olfactory tubercle RGD PMID:12093594 RGD:616951833 NCBI chr15:39,624,635...39,652,463
Ensembl chr15:43,800,246...43,827,470
JBrowse link
G Pomc proopiomelanocortin multiple interactions
increases secretion
increases expression
ISO
EXP
[Clonidine results in increased expression of POMC protein] which results in increased susceptibility to Naloxone; Naloxone binds to and results in increased activity of POMC protein alternative form
Naloxone results in increased secretion of POMC protein modified form
[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein; [CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased secretion of POMC protein modified form]; [Morphine co-treated with Naloxone] results in increased secretion of POMC protein; Capsaicin inhibits the reaction [[Clonidine co-treated with Naloxone co-treated with Morphine] results in increased secretion of POMC protein]; Capsaicin inhibits the reaction [[Morphine co-treated with Naloxone] results in increased secretion of POMC protein]
Naloxone results in increased expression of POMC protein alternative form
CTD PMID:2255747 PMID:2846107 PMID:3157294 PMID:6089027 PMID:24398105 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
G Prl prolactin affects expression
decreases expression
ISO
EXP
Naloxone affects the expression of PRL protein
Naloxone results in decreased expression of PRL protein
CTD PMID:1794335 PMID:7629406 NCBI chr17:38,287,355...38,298,234
Ensembl chr17:38,288,162...38,298,217
JBrowse link
G Ptma prothymosin alpha decreases expression EXP Naloxone results in decreased expression of PTMA mRNA CTD PMID:17522070 NCBI chr 9:94,624,194...94,628,276
Ensembl chr 9:94,624,196...94,628,276
JBrowse link
G Ren renin increases activity ISO Naloxone results in increased activity of REN protein CTD PMID:3157294 NCBI chr13:47,348,312...47,359,539
Ensembl chr13:47,348,143...47,359,543
JBrowse link
G Sell selectin L multiple interactions EXP Naloxone inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form] CTD PMID:10070497 NCBI chr13:78,950,100...78,969,604
Ensembl chr13:78,950,015...78,969,600
JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP [naloxone cotreatment with morphine] inhibits the reaction [morphine decreases expression of GLT-1 protein in cultured astrocytes] RGD PMID:28341892 RGD:597978120 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]] CTD PMID:11723065 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Naloxone inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Naloxone inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions ISO Naloxone inhibits the reaction [Morphine results in increased expression of SMPD1 protein] CTD PMID:22825003 NCBI chr 1:169,304,772...169,308,615
Ensembl chr 1:169,304,708...169,308,614
JBrowse link
G Spin2b spindlin family member 2B decreases expression EXP Naloxone results in decreased expression of SPIN2B mRNA CTD PMID:17522070 NCBI chr  X:17,190,573...17,192,351
Ensembl chr  X:19,842,295...19,925,734
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Naloxone results in decreased expression of SREBF1 mRNA CTD PMID:17522070 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Naloxone inhibits the reaction [Morphine results in increased expression of TAC1 protein] CTD PMID:11976266 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546
JBrowse link
G Th tyrosine hydroxylase multiple interactions
increases phosphorylation
EXP
ISO
[CP 154526 binds to and results in decreased activity of CRHR1 protein] inhibits the reaction [Naloxone results in increased phosphorylation of TH protein]; [Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein
[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein; CRHR1 gene mutant form inhibits the reaction [[Morphine co-treated with Naloxone] results in increased phosphorylation of TH protein]
CTD PMID:24398105 PMID:25308750 PMID:25582704 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Thrsp thyroid hormone responsive decreases expression EXP Naloxone results in decreased expression of THRSP mRNA CTD PMID:17522070 NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:161,133,453...161,139,827
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression EXP Naloxone results in increased expression of TIMP1 mRNA CTD PMID:17522070 NCBI chr  X:3,766,509...3,772,578
Ensembl chr  X:3,766,510...3,771,135
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Naloxone affects the reaction [Methadone binds to TLR4 protein]; Naloxone affects the reaction [Morphine binds to TLR4 protein] CTD PMID:20178837 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Naloxone results in decreased expression of TNF protein
CTD PMID:16004788 PMID:17084265 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression EXP Naloxone results in decreased expression of TNFRSF1A mRNA CTD PMID:17522070 NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:159,837,032...159,849,816
JBrowse link
G Tp53 tumor protein p53 multiple interactions
decreases expression
ISO
EXP
Naloxone inhibits the reaction [Morphine inhibits the reaction [Dactinomycin results in increased expression of TP53 protein modified form]]; Naloxone inhibits the reaction [Morphine results in increased expression of TP53]; Naloxone inhibits the reaction [Morphine results in increased phosphorylation of TP53 protein]
Naloxone results in decreased expression of TP53 mRNA
CTD PMID:12927789 PMID:17522070 PMID:19397953 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
JBrowse link
G Txn1 thioredoxin 1 increases expression EXP Naloxone results in increased expression of TXN mRNA CTD PMID:17522070 NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:77,507,321...77,520,307
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects metabolic processing
increases glucuronidation
ISO UGT2B7 protein affects the metabolism of Naloxone
UGT2B7 protein results in increased glucuronidation of Naloxone
CTD PMID:15286053 PMID:28762043 NCBI chr14:21,251,535...21,274,451
Ensembl chr14:21,251,535...21,274,451
JBrowse link
naltrexone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased cleavage of ATF6 protein] CTD PMID:27323860 NCBI chr13:85,460,312...85,639,959
Ensembl chr13:85,462,840...85,640,033
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
increases secretion
EXP Naltrexone affects the reaction [Dynorphins results in decreased secretion of CRH protein]; Naltrexone inhibits the reaction [beta-Endorphin results in decreased secretion of CRH protein]
Naltrexone results in increased secretion of CRH protein
CTD PMID:3031743 NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:104,058,770...104,061,386
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 mRNA]; Naltrexone inhibits the reaction [Methamphetamine results in increased expression of DDIT3 protein] CTD PMID:27323860 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:65,005,501...65,006,509
JBrowse link
G Drd2 dopamine receptor D2 affects response to substance ISO DRD2 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO Naltrexone promotes the reaction [Ethanol results in increased expression of EGR1 mRNA]
Naltrexone results in increased expression of EGR1 mRNA
CTD PMID:18427989 NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,736,838...26,740,843
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of EIF2AK3 protein] CTD PMID:27323860 NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:104,363,833...104,425,268
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased phosphorylation of ERN1 protein] CTD PMID:27323860 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,830,428...91,920,791
JBrowse link
G Fshb follicle stimulating hormone subunit beta increases secretion
increases expression
ISO Naltrexone results in increased secretion of FSHB protein
Naltrexone results in increased expression of FSHB protein
CTD PMID:6323369 PMID:7745028 NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:114,003,262...114,007,072
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 affects response to substance ISO GABRA6 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:27,311,979...27,327,234
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 affects response to substance ISO GABRB2 affects the susceptibility to Naltrexone CTD PMID:19523047 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:27,438,238...27,655,171
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Naltrexone inhibits the reaction [Methamphetamine results in increased expression of HSPA5 mRNA] CTD PMID:27323860 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO [Cannabidiol co-treated with Naltrexone] results in decreased expression of HTR1A mRNA CTD PMID:29859012 NCBI chr 2:38,427,169...38,431,733
Ensembl chr 2:38,427,083...38,540,760
JBrowse link
G Lhb luteinizing hormone subunit beta increases expression
increases secretion
ISO Naltrexone results in increased expression of LHB protein
Naltrexone results in increased secretion of LHB protein
CTD PMID:6323369 PMID:7745028 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:105,037,457...105,038,445
JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity ISO Naltrexone results in decreased activity of NOS2 protein CTD PMID:15694688 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Ogfr opioid growth factor receptor increases expression ISO Naltrexone results in increased expression of OGFR CTD PMID:21685240 NCBI chr 3:188,080,743...188,087,028
Ensembl chr 3:188,080,042...188,087,471
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Naltrexone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Naltrexone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
affects response to substance
ISO
EXP
[[Naltrexone binds to and results in decreased activity of OPRM1 protein] which co-treated with Morphine] results in increased expression of Cyclic AMP
[Cannabidiol co-treated with Naltrexone] results in decreased expression of OPRM1 mRNA
Naltrexone binds to OPRM1 protein
OPRM1 affects the susceptibility to Naltrexone
CTD PMID:7562497 PMID:11413242 PMID:18250251 PMID:29859012 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
affects response to substance
ISO Naltrexone inhibits the reaction [Enkephalin, Leucine-2-Alanine inhibits the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]]
SLC6A3 gene polymorphism affects the susceptibility to Naltrexone
CTD PMID:9765353 PMID:18552399 NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:31,537,990...31,578,962
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO [Cannabidiol co-treated with Naltrexone] results in decreased expression of TH mRNA CTD PMID:29859012 NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:207,500,962...207,557,227
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Naltrexone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:15917999 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
norcodeine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP2D22 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of Codeine] which results in increased chemical synthesis of norcodeine CTD PMID:16595712 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
oxycodone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 increases expression EXP Oxycodone results in increased expression of ABCA8 mRNA CTD PMID:23439660 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:95,416,205...95,490,452
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP Oxycodone results in increased expression of ABCB1A mRNA; Oxycodone results in increased expression of ABCB1A protein CTD PMID:23439660 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:26,312,409...26,397,135
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP Oxycodone results in increased expression of ABCB4 mRNA CTD PMID:23439660 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression EXP Oxycodone results in decreased expression of ABCG1 mRNA CTD PMID:23439660 NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,127,803...9,186,563
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Oxycodone results in increased expression of ABCG5 mRNA CTD PMID:23439660 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376
JBrowse link
G Abhd6 abhydrolase domain containing 6, acylglycerol lipase increases expression EXP Oxycodone results in increased expression of ABHD6 mRNA CTD PMID:23439660 NCBI chr15:16,859,740...16,907,094
Ensembl chr15:19,289,969...19,337,193
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression EXP Oxycodone results in increased expression of ACSM2A mRNA CTD PMID:23439660 NCBI chr 1:183,347,705...183,386,453
Ensembl chr 1:183,347,705...183,386,453
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP Oxycodone results in decreased expression of ACTN1 mRNA CTD PMID:23439660 NCBI chr 6:104,731,485...104,826,312
Ensembl chr 6:104,731,485...104,826,172
JBrowse link
G Adam17 ADAM metallopeptidase domain 17 decreases expression EXP Oxycodone results in decreased expression of ADAM17 mRNA CTD PMID:23439660 NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:46,601,583...46,649,344
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 increases expression EXP Oxycodone results in increased expression of ADAMTS1 mRNA CTD PMID:23439660 NCBI chr11:38,418,565...38,427,384
Ensembl chr11:38,418,101...38,427,390
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 decreases expression EXP Oxycodone results in decreased expression of ADGRE1 mRNA CTD PMID:23439660 NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,329,438...2,484,959
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP Oxycodone results in increased expression of AHR mRNA CTD PMID:23439660 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression EXP Oxycodone results in decreased expression of AKR1C3 mRNA CTD PMID:23439660 NCBI chr17:71,020,884...71,037,779
Ensembl chr17:70,970,900...71,048,438
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases expression EXP
ISO
Oxycodone increases expression of Akt1 mRNA in the hippocampal formation
Oxycodone increases expression of Akt1 mRNA in the hippocampus
RGD PMID:31071414 PMID:25446355 RGD:405866388, RGD:407445976 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
JBrowse link
G Anxa3 annexin A3 decreases expression EXP Oxycodone results in decreased expression of ANXA3 mRNA CTD PMID:23439660 NCBI chr14:13,031,675...13,085,678
Ensembl chr14:13,023,762...13,085,849
JBrowse link
G Arhgdib Rho GDP dissociation inhibitor beta decreases expression EXP Oxycodone results in decreased expression of ARHGDIB mRNA CTD PMID:23439660 NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:171,554,140...171,573,068
JBrowse link
G Asl argininosuccinate lyase increases expression EXP Oxycodone results in increased expression of ASL mRNA CTD PMID:23439660 NCBI chr12:32,295,779...32,313,257
Ensembl chr12:32,295,633...32,317,261
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO
EXP
Oxycodone results in increased expression of ATF4 protein CTD PMID:26377394 NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:113,684,681...113,686,739
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression EXP Oxycodone results in increased expression of ATP1B1 mRNA CTD PMID:23439660 NCBI chr13:79,319,708...79,340,226
Ensembl chr13:79,319,706...79,340,549
JBrowse link
G B4galnt1 beta-1,4-N-acetyl-galactosaminyl transferase 1 increases expression EXP Oxycodone results in increased expression of B4GALNT1 mRNA CTD PMID:23439660 NCBI chr 7:64,873,909...64,881,512
Ensembl chr 7:64,874,022...64,881,516
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression EXP Oxycodone results in decreased expression of BCL2A1 mRNA CTD PMID:23439660 NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:98,596,650...98,604,890
JBrowse link
G Blvra biliverdin reductase A decreases expression EXP Oxycodone results in decreased expression of BLVRA mRNA CTD PMID:23439660 NCBI chr 3:134,793,397...134,819,367
Ensembl chr 3:134,794,203...134,819,785
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP Oxycodone results in decreased expression of CA3 mRNA CTD PMID:23439660 NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:88,491,670...88,500,524
JBrowse link
G Cav2 caveolin 2 decreases expression EXP Oxycodone results in decreased expression of CAV2 mRNA CTD PMID:23439660 NCBI chr 4:46,582,681...46,590,058
Ensembl chr 4:46,582,096...46,591,425
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 decreases expression EXP Oxycodone results in decreased expression of CCL6 mRNA CTD PMID:23439660 NCBI chr10:68,863,994...68,868,928
Ensembl chr10:68,863,995...68,868,877
JBrowse link
G Cd5l Cd5 molecule-like decreases expression EXP Oxycodone results in decreased expression of CD5L mRNA CTD PMID:23439660 NCBI chr 2:175,088,915...175,099,928
Ensembl chr 2:175,088,884...175,099,926
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Oxycodone results in increased expression of CDKN1A mRNA CTD PMID:23439660 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
JBrowse link
G Ces2h carboxylesterase 2H affects expression
increases expression
EXP Oxycodone affects the expression of CES2 mRNA
Oxycodone results in increased expression of CES2 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
G Chd1l chromodomain helicase DNA binding protein 1-like increases expression EXP Oxycodone results in increased expression of CHD1L mRNA CTD PMID:23439660 NCBI chr 2:187,819,869...187,906,359
Ensembl chr 2:187,811,954...187,890,477
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 decreases expression EXP Oxycodone results in decreased expression of CMTM6 mRNA CTD PMID:23439660 NCBI chr 8:123,301,131...123,319,230
Ensembl chr 8:123,300,918...123,319,230
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase decreases expression EXP Oxycodone results in decreased expression of CNP1 mRNA CTD PMID:23439660 NCBI chr10:86,011,504...86,018,063
Ensembl chr10:86,011,495...86,018,063
JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 decreases expression EXP Oxycodone results in decreased expression of COTL1 mRNA CTD PMID:23439660 NCBI chr19:64,780,309...64,814,629
Ensembl chr19:64,780,322...64,814,840
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO Oxycodone inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of CREB1 protein] CTD PMID:39358233 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 decreases expression EXP Oxycodone results in decreased expression of CSRP1 mRNA CTD PMID:23439660 NCBI chr13:49,709,928...49,731,141
Ensembl chr13:49,709,914...49,731,139
JBrowse link
G Ctsc cathepsin C decreases expression EXP Oxycodone results in decreased expression of CTSC mRNA CTD PMID:23439660 NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:151,441,032...151,474,082
JBrowse link
G Ctsl cathepsin L increases expression EXP Oxycodone results in increased expression of CTSL mRNA CTD PMID:23439660 NCBI chr17:770,104...776,266
Ensembl chr17:770,093...777,113
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP Oxycodone results in decreased expression of CYBA mRNA CTD PMID:23439660 NCBI chr19:67,396,143...67,404,214
Ensembl chr19:67,396,143...67,404,214
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 affects expression
increases expression
EXP Oxycodone affects the expression of CYP17A1 mRNA
Oxycodone results in increased expression of CYP17A1 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP27A1 mRNA CTD PMID:23439660 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:83,713,293...83,743,215
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP2A1 mRNA CTD PMID:23439660 NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:91,359,272...91,389,730
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 affects expression
increases expression
EXP Oxycodone affects the expression of CYP2B2 mRNA
Oxycodone results in increased expression of CYP2B2 mRNA; Oxycodone results in increased expression of CYP2B2 protein
CTD PMID:20487198 PMID:23439660 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Oxycodone results in decreased expression of CYP2C11 mRNA CTD PMID:23439660 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:246,174,711...246,211,853
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 affects expression
decreases expression
EXP Oxycodone affects the expression of CYP2C13 mRNA
Oxycodone results in decreased expression of CYP2C13 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:248,706,788...248,787,210
JBrowse link
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 decreases expression EXP Oxycodone results in decreased expression of CYP2C9 mRNA CTD PMID:23439660 NCBI chr 1:247,966,295...248,022,393
Ensembl chr 1:247,966,346...248,022,388
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects response to substance
multiple interactions
ISO CYP2D6 gene polymorphism affects the susceptibility to Oxycodone
[Quinidine results in decreased activity of CYP2D6 protein] which affects the susceptibility to Oxycodone
CTD PMID:20590588 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP2E1 mRNA CTD PMID:23439660 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 increases expression EXP Oxycodone results in increased expression of CYP2J4 mRNA CTD PMID:23439660 NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:116,295,694...116,323,042
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
decreases expression
EXP
ISO
Oxycodone inhibits the reaction [CYP3A2 protein results in increased hydroxylation of Testosterone]
CYP3A4 protein alternative form affects the metabolism of Oxycodone
telithromycin inhibits the reaction [CYP3A4 protein results in decreased methylation of Oxycodone]
Oxycodone results in decreased expression of CYP3A2 mRNA; Oxycodone results in decreased expression of CYP3A2 protein
CTD PMID:19755414 PMID:20487198 PMID:33393779 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:14,321,771...14,343,857
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP3A23-3A1 mRNA; Oxycodone results in increased expression of CYP3A23-3A1 protein CTD PMID:23439660 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:14,368,266...14,398,813
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP4A10 mRNA CTD PMID:23439660 NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:134,360,111...134,374,231
JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 increases expression EXP Oxycodone results in increased expression of CYP4B1 mRNA CTD PMID:23439660 NCBI chr 5:134,375,807...134,413,635
Ensembl chr 5:134,375,807...134,393,116
JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 increases expression EXP Oxycodone results in increased expression of DBT mRNA CTD PMID:23439660 NCBI chr 2:204,481,744...204,510,612
Ensembl chr 2:207,166,652...207,195,525
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression EXP Oxycodone results in increased expression of EHHADH mRNA CTD PMID:23439660 NCBI chr11:92,746,409...92,779,647
Ensembl chr11:92,746,420...92,779,662
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions
increases phosphorylation
ISO
EXP
Naloxone inhibits the reaction [Oxycodone results in increased phosphorylation of EIF2S1 protein] CTD PMID:26377394 NCBI chr 6:103,405,880...103,430,549
Ensembl chr 6:103,405,788...103,431,649
JBrowse link
G Ell2 elongation factor for RNA polymerase II 2 increases expression EXP Oxycodone results in increased expression of ELL2 mRNA CTD PMID:23439660 NCBI chr 2:6,910,446...6,990,654
Ensembl chr 2:6,921,771...7,016,199
JBrowse link
G Ephx2 epoxide hydrolase 2 affects expression EXP Oxycodone affects the expression of EPHX2 mRNA CTD PMID:20487198 NCBI chr15:44,465,447...44,503,157
Ensembl chr15:44,465,448...44,503,160
JBrowse link
G Exosc5 exosome component 5 increases expression EXP Oxycodone results in increased expression of EXOSC5 mRNA CTD PMID:23439660 NCBI chr 1:90,295,495...90,305,047
Ensembl chr 1:90,293,797...90,305,046
JBrowse link
G Fcgr2a Fc gamma receptor 2A decreases expression EXP Oxycodone results in decreased expression of FCGR2A mRNA CTD PMID:23439660 NCBI chr13:85,813,516...85,830,269
Ensembl chr13:85,855,437...85,864,394
Ensembl chr13:85,855,437...85,864,394
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 increases expression EXP Oxycodone results in increased expression of FKBP5 mRNA CTD PMID:23439660 NCBI chr20:6,458,931...6,577,227
Ensembl chr20:6,458,940...6,543,118
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 affects expression
increases expression
EXP Oxycodone affects the expression of FMO1 mRNA
Oxycodone results in increased expression of FMO1 mRNA
CTD PMID:20487198 PMID:23439660 NCBI chr13:77,715,405...77,747,666
Ensembl chr13:77,715,402...77,747,874
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Oxycodone results in increased expression of FOS protein CTD PMID:26377394 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598
JBrowse link
G Foxo1 forkhead box O1 increases expression EXP Oxycodone results in increased expression of FOXO1A mRNA CTD PMID:23439660 NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:138,462,697...138,541,419
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression EXP Oxycodone results in increased expression of GPAM mRNA CTD PMID:23439660 NCBI chr 1:264,111,599...264,176,112
Ensembl chr 1:264,113,813...264,175,911
JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Oxycodone results in increased expression of GPT mRNA CTD PMID:23439660 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 increases expression EXP Oxycodone results in increased expression of GPT2 mRNA CTD PMID:23439660 NCBI chr19:37,700,023...37,734,551
Ensembl chr19:37,691,901...37,733,917
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP Oxycodone results in increased expression of GSTA3 mRNA CTD PMID:23439660 NCBI chr 9:31,154,989...31,180,653
Ensembl chr 9:31,154,989...31,180,654
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP Oxycodone results in increased expression of GSTA5 mRNA; Oxycodone results in increased expression of GSTA5 protein CTD PMID:20487198 NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:87,985,258...87,997,765
JBrowse link
G Hacl1 2-hydroxyacyl-CoA lyase 1 increases expression EXP Oxycodone results in increased expression of HACL1 mRNA CTD PMID:23439660 NCBI chr16:6,831,293...6,869,410
Ensembl chr16:6,833,268...6,869,410
JBrowse link
G Hao2 hydroxyacid oxidase 2 decreases expression EXP Oxycodone results in decreased expression of HAO2 mRNA CTD PMID:23439660 NCBI chr 2:188,888,848...188,921,567
Ensembl chr 2:188,889,212...188,913,133
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases expression EXP Oxycodone results in decreased expression of HCK mRNA CTD PMID:23439660 NCBI chr 3:162,031,833...162,074,933
Ensembl chr 3:162,031,817...162,074,935
JBrowse link
G Hexb hexosaminidase subunit beta increases expression EXP Oxycodone results in increased expression of HEXB mRNA CTD PMID:23439660 NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:30,218,608...30,238,771
JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B increases expression EXP Oxycodone results in increased expression of HNRNPAB mRNA CTD PMID:23439660 NCBI chr10:36,358,004...36,363,898
Ensembl chr10:36,358,006...36,364,307
JBrowse link
G Homer1 homer scaffold protein 1 increases expression EXP Oxycodone results in increased expression of HOMER1 mRNA CTD PMID:23439660 NCBI chr 2:26,279,012...26,388,279
Ensembl chr 2:26,278,105...26,381,657
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression EXP Oxycodone results in decreased expression of HSD11B1 mRNA CTD PMID:23439660 NCBI chr13:107,277,526...107,327,462
Ensembl chr13:107,257,239...107,327,432
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO
EXP
Oxycodone results in increased expression of HSPA5 protein CTD PMID:26377394 NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:38,453,041...38,458,790
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit decreases expression EXP Oxycodone results in decreased expression of IGFALS mRNA CTD PMID:23439660 NCBI chr10:14,397,076...14,408,439
Ensembl chr10:14,403,399...14,407,138
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP Oxycodone results in increased expression of IGFBP1 mRNA CTD PMID:23439660 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344
JBrowse link
G Il18bp interleukin 18 binding protein decreases expression EXP Oxycodone results in decreased expression of IL18BP mRNA CTD PMID:23439660 NCBI chr 1:165,784,916...165,787,990
Ensembl chr 1:165,784,069...165,786,955
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Oxycodone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] CTD PMID:39358233 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Oxycodone inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]] CTD PMID:39358233 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
JBrowse link
G Inhbe inhibin subunit beta E decreases expression EXP Oxycodone results in decreased expression of INHBE mRNA CTD PMID:23439660 NCBI chr 7:65,061,531...65,064,519
Ensembl chr 7:65,061,531...65,064,519
JBrowse link
G Ip6k2 inositol hexakisphosphate kinase 2 increases expression EXP Oxycodone results in increased expression of IP6K2 mRNA CTD PMID:23439660 NCBI chr 8:118,362,154...118,388,668
Ensembl chr 8:118,362,795...118,388,667
JBrowse link
G Itgb2 integrin subunit beta 2 decreases expression EXP Oxycodone results in decreased expression of ITGB2 mRNA CTD PMID:23439660 NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,058,492...11,097,182
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP Oxycodone results in increased expression of ITPR1 mRNA CTD PMID:23439660 NCBI chr 4:142,743,401...143,066,505
Ensembl chr 4:142,743,334...143,066,504
JBrowse link
G Jchain joining chain of multimeric IgA and IgM decreases expression EXP Oxycodone results in decreased expression of JCHAIN mRNA CTD PMID:23439660 NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,822,976...19,838,307
JBrowse link
G Klc4 kinesin light chain 4 increases expression EXP Oxycodone results in increased expression of KLC4 mRNA CTD PMID:23439660 NCBI chr 9:21,834,765...21,848,676
Ensembl chr 9:21,835,092...21,848,675
JBrowse link
G Lcp1 lymphocyte cytosolic protein 1 decreases expression EXP Oxycodone results in decreased expression of LCP1 mRNA CTD PMID:23439660 NCBI chr15:56,846,375...56,954,090
Ensembl chr15:56,847,433...56,954,092
JBrowse link
G Lgals3 galectin 3 decreases expression EXP Oxycodone results in decreased expression of LGALS3 mRNA CTD PMID:23439660 NCBI chr15:23,099,795...23,111,731
Ensembl chr15:23,086,841...23,111,737
JBrowse link
G Lhpp phospholysine phosphohistidine inorganic pyrophosphate phosphatase increases expression EXP Oxycodone results in increased expression of LHPP mRNA CTD PMID:23439660 NCBI chr 1:196,833,516...196,924,687
Ensembl chr 1:196,833,523...196,924,871
JBrowse link
G Lin7a lin-7 homolog A, crumbs cell polarity complex component decreases expression EXP Oxycodone results in decreased expression of LIN7A mRNA CTD PMID:23439660 NCBI chr 7:42,586,704...42,742,609
Ensembl chr 7:44,473,347...44,625,208
JBrowse link
G Ly86 lymphocyte antigen 86 decreases expression EXP Oxycodone results in decreased expression of LY86 mRNA CTD PMID:23439660 NCBI chr17:27,621,313...27,705,336
Ensembl chr17:27,621,313...27,692,743
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP Oxycodone results in increased phosphorylation of MAPK1 protein CTD PMID:26377394 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP Oxycodone results in increased phosphorylation of MAPK3 protein CTD PMID:26377394 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Masp1 MBL associated serine protease 1 decreases expression EXP Oxycodone results in decreased expression of MASP1 mRNA CTD PMID:23439660 NCBI chr11:90,839,081...90,909,922
Ensembl chr11:90,839,061...90,917,470
JBrowse link
G Mir181c microRNA 181c multiple interactions ISO Oxycodone inhibits the reaction [Lipopolysaccharides results in decreased expression of MIR181C protein]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of PDCD4 protein]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:39358233 NCBI chr19:40,888,291...40,888,396
Ensembl chr19:40,888,291...40,888,396
JBrowse link
G Mtmr7 myotubularin related protein 7 increases expression EXP Oxycodone results in increased expression of MTMR7 mRNA CTD PMID:23439660 NCBI chr16:51,641,267...51,732,212
Ensembl chr16:58,344,767...58,436,615
JBrowse link
G Myo1b myosin Ib increases expression EXP Oxycodone results in increased expression of MYO1B mRNA CTD PMID:23439660 NCBI chr 9:57,182,059...57,344,335
Ensembl chr 9:57,181,987...57,344,328
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Oxycodone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] CTD PMID:39358233 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
JBrowse link
G Notch2 notch receptor 2 decreases expression EXP Oxycodone results in decreased expression of NOTCH2 mRNA CTD PMID:23439660 NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:188,299,336...188,432,823
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression EXP Oxycodone results in increased expression of NR1I2 mRNA CTD PMID:23439660 NCBI chr11:75,965,717...76,006,733
Ensembl chr11:75,965,632...76,002,380
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression EXP Oxycodone results in increased expression of NR1I3 mRNA CTD PMID:23439660 NCBI chr13:86,165,327...86,170,362
Ensembl chr13:86,165,349...86,170,370
JBrowse link
G Nrep neuronal regeneration related protein decreases expression EXP Oxycodone results in decreased expression of NREP mRNA CTD PMID:23439660 NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,291,219...25,320,742
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP Oxycodone binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding EXP Oxycodone binds to OPRK1 protein CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP Oxycodone binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Orm1 orosomucoid 1 decreases expression EXP Oxycodone results in decreased expression of ORM1 mRNA CTD PMID:23439660 NCBI chr 5:81,788,509...81,791,661
Ensembl chr 5:81,788,395...81,791,667
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression EXP Oxycodone results in decreased expression of OSGIN1 mRNA CTD PMID:23439660 NCBI chr19:64,380,336...64,409,165
Ensembl chr19:64,401,173...64,409,162
JBrowse link
G Pdcd4 programmed cell death 4 multiple interactions ISO Oxycodone inhibits the reaction [Lipopolysaccharides results in increased expression of PDCD4 protein]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 protein]]]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of PDCD4 protein]] CTD PMID:39358233 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:262,926,656...262,950,189
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP Oxycodone results in decreased expression of PDE4B mRNA CTD PMID:23439660 NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:122,135,174...122,598,267
JBrowse link
G Pdgfra platelet derived growth factor receptor alpha increases expression EXP Oxycodone results in increased expression of PDGFRA protein CTD PMID:26377394 NCBI chr14:33,360,027...33,408,604
Ensembl chr14:33,360,028...33,408,516
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression EXP Oxycodone results in increased expression of PFKFB1 mRNA CTD PMID:23439660 NCBI chr  X:22,936,038...22,989,691
Ensembl chr  X:22,937,494...22,989,704
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases expression EXP Oxycodone results in decreased expression of PIK3C3 mRNA CTD PMID:23439660 NCBI chr18:22,119,677...22,203,546
Ensembl chr18:22,119,792...22,203,539
JBrowse link
G Pla2g4a phospholipase A2 group 4A decreases expression EXP Oxycodone results in decreased expression of PLA2G4A mRNA CTD PMID:23439660 NCBI chr13:64,427,921...64,572,352
Ensembl chr13:64,427,916...64,589,641
JBrowse link
G Pld1 phospholipase D1 decreases expression EXP Oxycodone results in decreased expression of PLD1 mRNA CTD PMID:23439660 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:112,777,951...112,976,245
JBrowse link
G Plscr1 phospholipid scramblase 1 decreases expression EXP Oxycodone results in decreased expression of PLSCR1 mRNA CTD PMID:23439660 NCBI chr 8:101,662,512...101,684,474
Ensembl chr 8:101,664,056...101,684,614
JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 increases expression EXP Oxycodone results in increased expression of PNPLA7 mRNA CTD PMID:23439660 NCBI chr 3:28,180,670...28,259,673
Ensembl chr 3:28,180,751...28,259,672
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression EXP Oxycodone results in increased expression of POR mRNA CTD PMID:23439660 NCBI chr12:26,587,674...26,655,612
Ensembl chr12:26,587,674...26,635,809
JBrowse link
G Prkab1 protein kinase AMP-activated non-catalytic subunit beta 1 decreases expression EXP Oxycodone results in decreased expression of PRKAB1 mRNA CTD PMID:23439660 NCBI chr12:46,248,971...46,259,487
Ensembl chr12:46,249,010...46,259,482
JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha increases phosphorylation EXP Oxycodone results in increased phosphorylation of PRKACA protein CTD PMID:26377394 NCBI chr19:41,059,843...41,083,189
Ensembl chr19:41,059,843...41,086,494
JBrowse link
G Prlr prolactin receptor increases expression EXP Oxycodone results in increased expression of PRLR mRNA CTD PMID:23439660 NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:60,861,658...61,051,882
JBrowse link
G Ptdss2 phosphatidylserine synthase 2 increases expression EXP Oxycodone results in increased expression of PTDSS2 mRNA CTD PMID:23439660 NCBI chr 1:196,241,439...196,267,632
Ensembl chr 1:205,671,041...205,695,553
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression EXP Oxycodone results in increased expression of PTP4A1 mRNA CTD PMID:23439660 NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:40,710,250...40,718,176
JBrowse link
G Pxmp4 peroxisomal membrane protein 4 increases expression EXP Oxycodone results in increased expression of PXMP4 mRNA CTD PMID:23439660 NCBI chr 3:163,553,582...163,570,829
Ensembl chr 3:163,553,599...163,570,829
JBrowse link
G Pycard PYD and CARD domain containing decreases expression EXP Oxycodone results in decreased expression of PYCARD mRNA CTD PMID:23439660 NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:192,032,124...192,033,419
JBrowse link
G Rab30 RAB30, member RAS oncogene family increases expression EXP Oxycodone results in increased expression of RAB30 mRNA CTD PMID:23439660 NCBI chr 1:156,216,137...156,310,778
Ensembl chr 1:156,216,137...156,310,778
JBrowse link
G Rab38 RAB38, member RAS oncogene family decreases expression EXP Oxycodone results in decreased expression of RAB38 mRNA CTD PMID:23439660 NCBI chr 1:151,595,153...151,675,492
Ensembl chr 1:151,595,078...151,675,493
JBrowse link
G Rac2 Rac family small GTPase 2 decreases expression EXP Oxycodone results in decreased expression of RAC2 mRNA CTD PMID:23439660 NCBI chr 7:111,981,825...112,009,201
Ensembl chr 7:111,996,742...112,009,267
JBrowse link
G Rcan1 regulator of calcineurin 1 decreases expression EXP Oxycodone results in decreased expression of RCAN1 mRNA CTD PMID:23439660 NCBI chr11:45,108,123...45,188,065
Ensembl chr11:45,108,124...45,118,236
JBrowse link
G Serpina7 serpin family A member 7 decreases expression EXP Oxycodone results in decreased expression of SERPINA7 mRNA CTD PMID:23439660 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:107,452,044...107,457,681
JBrowse link
G Skap2 src kinase associated phosphoprotein 2 decreases expression EXP Oxycodone results in decreased expression of SKAP2 mRNA CTD PMID:23439660 NCBI chr 4:82,281,221...82,431,664
Ensembl chr 4:82,263,709...82,432,886
JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression EXP Oxycodone results in decreased expression of SLC10A2 mRNA CTD PMID:23439660 NCBI chr16:91,088,089...91,111,025
Ensembl chr16:91,076,423...91,111,025
JBrowse link
G Slc15a3 solute carrier family 15 member 3 decreases expression EXP Oxycodone results in decreased expression of SLC15A3 mRNA CTD PMID:23439660 NCBI chr 1:216,906,836...216,932,046
Ensembl chr 1:216,916,675...216,932,045
JBrowse link
G Slc16a1 solute carrier family 16 member 1 decreases expression EXP Oxycodone results in decreased expression of SLC16A1 mRNA CTD PMID:23439660 NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:194,812,502...194,832,977
JBrowse link
G Slc16a10 solute carrier family 16 member 10 increases expression EXP Oxycodone results in increased expression of SLC16A10 mRNA CTD PMID:23439660 NCBI chr20:45,014,229...45,122,392
Ensembl chr20:45,014,235...45,122,358
JBrowse link
G Slc17a5 solute carrier family 17 member 5 increases expression EXP Oxycodone results in increased expression of SLC17A5 mRNA CTD PMID:23439660 NCBI chr 8:88,274,497...88,309,734
Ensembl chr 8:88,274,721...88,309,664
JBrowse link
G Slc1a2 solute carrier family 1 member 2 increases expression EXP Oxycodone results in increased expression of SLC1A2 mRNA CTD PMID:23439660 NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:109,459,630...109,605,249
JBrowse link
G Slc22a5 solute carrier family 22 member 5 increases expression EXP Oxycodone results in increased expression of SLC22A5 mRNA CTD PMID:23439660 NCBI chr10:38,509,072...38,536,240
Ensembl chr10:38,509,072...38,536,077
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP Oxycodone results in decreased expression of SLC22A8 mRNA CTD PMID:23439660 NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588
JBrowse link
G Slc25a15 solute carrier family 25 member 15 increases expression EXP Oxycodone results in increased expression of SLC25A15 mRNA CTD PMID:23439660 NCBI chr16:76,334,037...76,357,325
Ensembl chr16:76,324,288...76,357,321
JBrowse link
G Slc25a29 solute carrier family 25 member 29 increases expression EXP Oxycodone results in increased expression of SLC25A29 mRNA CTD PMID:23439660 NCBI chr 6:127,742,027...127,752,915
Ensembl chr 6:133,506,331...133,517,827
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP Oxycodone results in decreased expression of SLC25A30 mRNA CTD PMID:23439660 NCBI chr15:51,076,998...51,099,613
Ensembl chr15:57,486,350...57,502,690
JBrowse link
G Slc27a5 solute carrier family 27 member 5 increases expression EXP Oxycodone results in increased expression of SLC27A5 mRNA CTD PMID:23439660 NCBI chr 1:82,688,742...82,699,335
Ensembl chr 1:82,688,750...82,699,358
JBrowse link
G Slc2a2 solute carrier family 2 member 2 increases expression EXP Oxycodone results in increased expression of SLC2A2 mRNA CTD PMID:23439660 NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:113,537,972...113,568,467
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression EXP Oxycodone results in decreased expression of SLC34A2 mRNA CTD PMID:23439660 NCBI chr14:62,123,313...62,153,020
Ensembl chr14:62,123,316...62,143,360
JBrowse link
G Slc35b2 solute carrier family 35 member B2 decreases expression EXP Oxycodone results in decreased expression of SLC35B2 mRNA CTD PMID:23439660 NCBI chr 9:22,936,031...22,940,114
Ensembl chr 9:22,935,887...22,939,793
JBrowse link
G Slc37a4 solute carrier family 37 member 4 increases expression EXP Oxycodone results in increased expression of SLC37A4 mRNA CTD PMID:23439660 NCBI chr 8:53,619,952...53,626,110
Ensembl chr 8:53,620,141...53,626,110
JBrowse link
G Slc38a4 solute carrier family 38, member 4 increases expression EXP Oxycodone results in increased expression of SLC38A4 mRNA CTD PMID:23439660 NCBI chr 7:130,022,039...130,082,169
Ensembl chr 7:130,023,980...130,082,097
JBrowse link
G Slc39a4 solute carrier family 39 member 4 increases expression EXP Oxycodone results in increased expression of SLC39A4 mRNA CTD PMID:23439660 NCBI chr 7:110,214,017...110,218,202
Ensembl chr 7:110,214,017...110,218,202
JBrowse link
G Slc41a2 solute carrier family 41 member 2 decreases expression EXP Oxycodone results in decreased expression of SLC41A2 mRNA CTD PMID:23439660 NCBI chr 7:22,271,298...22,378,764
Ensembl chr 7:22,271,313...22,378,764
JBrowse link
G Slc49a4 solute carrier family 49 member 4 increases expression EXP Oxycodone results in increased expression of SLC49A4 mRNA CTD PMID:23439660 NCBI chr11:78,500,918...78,574,205
Ensembl chr11:78,500,960...78,574,202
JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression EXP Oxycodone results in decreased expression of SLC6A9 mRNA CTD PMID:23439660 NCBI chr 5:136,660,022...136,694,173
Ensembl chr 5:136,659,948...136,694,172
JBrowse link
G Slc7a7 solute carrier family 7 member 7 decreases expression EXP Oxycodone results in decreased expression of SLC7A7 mRNA CTD PMID:23439660 NCBI chr15:31,792,122...31,852,732
Ensembl chr15:31,792,125...31,835,683
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases expression EXP Oxycodone results in increased expression of SLCO1B2 mRNA CTD PMID:23439660 NCBI chr 4:176,282,577...176,355,557
Ensembl chr 4:176,282,584...176,351,083
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression EXP Oxycodone results in decreased expression of SLPI mRNA CTD PMID:23439660 NCBI chr 3:173,501,573...173,503,822
Ensembl chr 3:173,501,573...173,503,822
JBrowse link
G Smarcd2 SWI/SNF related BAF chromatin remodeling complex subunit D2 increases expression EXP Oxycodone results in increased expression of SMARCD2 mRNA CTD PMID:23439660 NCBI chr10:91,693,542...91,702,408
Ensembl chr10:91,693,542...91,702,522
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP Oxycodone results in decreased expression of STAC3 mRNA CTD PMID:23439660 NCBI chr 7:65,227,151...65,235,884
Ensembl chr 7:65,228,352...65,235,878
JBrowse link
G Sulf2 sulfatase 2 increases expression EXP Oxycodone results in increased expression of SULF2 mRNA CTD PMID:23439660 NCBI chr 3:175,241,322...175,323,808
Ensembl chr 3:175,241,322...175,323,651
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression EXP Oxycodone results in decreased expression of SULT1A2 mRNA CTD PMID:23439660 NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:190,702,592...190,706,131
JBrowse link
G Sult2a6 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 6 increases expression EXP Oxycodone results in increased expression of SULT2A6 mRNA CTD PMID:23439660 NCBI chr 1:74,911,097...74,962,239
Ensembl chr 1:84,046,685...84,097,808
JBrowse link
G Sycp3 synaptonemal complex protein 3 increases expression EXP Oxycodone results in increased expression of SYCP3 mRNA CTD PMID:23439660 NCBI chr 7:24,761,476...24,775,933
Ensembl chr 7:24,761,463...24,776,501
JBrowse link
G Tars1 threonyl-tRNA synthetase 1 decreases expression EXP Oxycodone results in decreased expression of TARS1 mRNA CTD PMID:23439660 NCBI chr 2:62,095,978...62,114,802
Ensembl chr 2:62,087,763...62,114,802
JBrowse link
G Thumpd1 THUMP domain containing 1 decreases expression EXP Oxycodone results in decreased expression of THUMPD1 mRNA CTD PMID:23439660 NCBI chr 1:174,078,875...174,084,915
Ensembl chr 1:183,431,657...183,516,282
JBrowse link
G Timm8a1 translocase of inner mitochondrial membrane 8A1 increases expression EXP Oxycodone results in increased expression of TIMM8A mRNA CTD PMID:23439660 NCBI chr  X:102,011,206...102,015,444
Ensembl chr  X:102,011,206...102,015,444
JBrowse link
G Tle1 TLE family member 1, transcriptional corepressor increases expression EXP Oxycodone results in increased expression of TLE1 mRNA CTD PMID:23439660 NCBI chr 5:90,898,182...90,982,118
Ensembl chr 5:90,898,182...90,980,928
JBrowse link
G Tmem19 transmembrane protein 19 decreases expression EXP Oxycodone results in decreased expression of TMEM19 mRNA CTD PMID:23439660 NCBI chr 7:52,844,985...52,871,708
Ensembl chr 7:52,844,985...52,872,012
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Oxycodone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Oxycodone inhibits the reaction [PDCD4 protein inhibits the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]]; Oxycodone promotes the reaction [MIR181C inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:39358233 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tsc22d3 TSC22 domain family, member 3 increases expression EXP Oxycodone results in increased expression of TSC22D3 mRNA CTD PMID:23439660 NCBI chr  X:109,006,410...109,066,389
Ensembl chr  X:109,006,420...109,015,519
JBrowse link
G Tsku tsukushi, small leucine rich proteoglycan increases expression EXP Oxycodone results in increased expression of TSKU mRNA CTD PMID:23439660 NCBI chr 1:162,071,459...162,082,972
Ensembl chr 1:162,064,126...162,089,272
JBrowse link
G Tubb5 tubulin, beta 5 class I decreases expression EXP Oxycodone results in decreased expression of TUBB5 mRNA CTD PMID:23439660 NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,917,539...2,921,726
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Oxycodone results in increased expression of UGT1A1 mRNA CTD PMID:23439660 NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:96,144,786...96,256,264
JBrowse link
G Uox urate oxidase increases expression EXP Oxycodone results in increased expression of UOX mRNA CTD PMID:23439660 NCBI chr 2:235,486,867...235,523,053
Ensembl chr 2:238,083,686...238,183,370
JBrowse link
G Usp12 ubiquitin specific peptidase 12 decreases expression EXP Oxycodone results in decreased expression of USP12 mRNA CTD PMID:23439660 NCBI chr12:13,423,625...13,477,547
Ensembl chr12:13,422,427...13,477,547
JBrowse link
G Ust5r integral membrane transport protein UST5r decreases expression EXP Oxycodone results in decreased expression of UST5R mRNA CTD PMID:23439660 NCBI chr 1:205,210,558...205,286,868
Ensembl chr 1:214,640,172...214,715,861
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein decreases expression EXP Oxycodone results in decreased expression of VASP mRNA CTD PMID:23439660 NCBI chr 1:88,038,026...88,053,783
Ensembl chr 1:88,038,037...88,058,650
JBrowse link
G Vim vimentin decreases expression EXP Oxycodone results in decreased expression of VIM mRNA CTD PMID:23439660 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
G Zfp354a zinc finger protein 354A increases expression EXP Oxycodone results in increased expression of ZNF354A mRNA CTD PMID:23439660 NCBI chr10:35,897,217...35,909,063
Ensembl chr10:35,897,228...35,909,510
JBrowse link
pethidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces1d carboxylesterase 1D affects binding
increases hydrolysis
ISO Meperidine binds to CES1 protein
CES1 protein results in increased hydrolysis of Meperidine
CTD PMID:10381793 NCBI chr19:30,046,494...30,085,039
Ensembl chr19:30,046,449...30,085,449
JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Meperidine binds to CES2 protein CTD PMID:10381793 NCBI chr19:49,884,164...49,898,764
Ensembl chr19:49,884,164...49,898,752
JBrowse link
remifentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form] CTD PMID:34078833 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions
increases phosphorylation
EXP Ketamine inhibits the reaction [remifentanil results in increased phosphorylation of GRIN2B protein] CTD PMID:20042082 NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:170,322,617...170,773,570
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO remifentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
JBrowse link
G Mir205 microRNA 205 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of CASP3 protein modified form]]; [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA]]; [Antagomirs results in decreased expression of MIR205 mRNA] which results in increased susceptibility to Remifentanil; MIR205 mRNA inhibits the reaction [Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of CASP3 protein modified form]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in increased expression of MIR205 mRNA]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MIR205 mRNA] CTD PMID:34078833 NCBI chr13:107,564,535...107,564,642 JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions EXP [Antagomirs results in decreased expression of MIR205 mRNA] promotes the reaction [Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein]]; Remifentanil inhibits the reaction [[Oxygen co-treated with Dithionite] results in decreased expression of PINK1 protein]; Remifentanil inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PINK1 protein] CTD PMID:34078833 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions
affects localization
EXP Lidocaine inhibits the reaction [remifentanil affects the localization of PRKCG protein] CTD PMID:19955894 NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:74,748,272...74,774,814
JBrowse link
SNC-80 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421
JBrowse link
sufentanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr3a 5-hydroxytryptamine receptor 3A affects activity ISO Sufentanil affects the activity of HTR3A protein CTD PMID:18635474 NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Sufentanil results in decreased expression of POMC protein modified form CTD PMID:15714323 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:32,659,346...32,665,173
JBrowse link
tianeptine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP tianeptine results in increased expression of ABCC2 mRNA CTD PMID:27765674 NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:252,614,017...252,673,471
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP tianeptine results in increased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:15,717,936...15,743,376
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP tianeptine results in increased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:15,698,448...15,717,730
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO tianeptine results in decreased expression of ANGPTL3 mRNA CTD PMID:27089845 NCBI chr 5:118,818,494...118,825,531
Ensembl chr 5:118,818,499...118,826,444
JBrowse link
G Cat catalase multiple interactions EXP tianeptine inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:19497431 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Cnr2 cannabinoid receptor 2 increases expression EXP tianeptine results in increased expression of CNR2 protein CTD PMID:28866072 NCBI chr 5:153,408,968...153,435,092
Ensembl chr 5:153,409,147...153,435,961
JBrowse link
G Drd2 dopamine receptor D2 decreases expression EXP tianeptine results in decreased expression of DRD2 mRNA CTD PMID:11981225 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO tianeptine results in increased expression of IGFBP1 mRNA CTD PMID:27089845 NCBI chr14:86,261,277...86,266,344
Ensembl chr14:86,261,277...86,266,344
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP tianeptine inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:19497431 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
JBrowse link
G Oprm1 opioid receptor, mu 1 increases activity ISO tianeptine results in increased activity of OPRM1 protein CTD PMID:32734307 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP tianeptine results in decreased expression of SLC10A1 mRNA CTD PMID:27765674 NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:106,344,319...106,357,944
JBrowse link
G Slc6a4 solute carrier family 6 member 4 multiple interactions ISO tianeptine binds to and results in decreased activity of SLC6A4 protein CTD PMID:16272152 NCBI chr10:62,322,688...62,357,060
Ensembl chr10:62,324,254...62,357,056
JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 decreases expression EXP tianeptine results in decreased expression of SLCO1A1 mRNA CTD PMID:27765674 NCBI chr 4:174,877,045...174,950,900
Ensembl chr 4:176,607,687...176,681,992
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO tianeptine results in increased expression of SREBF1 mRNA CTD PMID:27089845 NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,507,152...45,529,164
JBrowse link
tramadol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1a adrenoceptor alpha 1A increases expression EXP Tramadol results in increased expression of ADRA1A protein CTD PMID:15464068 NCBI chr15:45,005,648...45,111,416
Ensembl chr15:45,005,799...45,102,534
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases expression
EXP Vitamin E inhibits the reaction [Tramadol results in increased expression of ALPL protein] CTD PMID:31618080 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP Tramadol results in increased expression of BAX protein CTD PMID:25550769 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
JBrowse link
G Bche butyrylcholinesterase decreases activity EXP Tramadol results in decreased activity of BCHE protein CTD PMID:28689766 NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:160,606,288...160,699,760
JBrowse link
G Casp3 caspase 3 affects activity
increases expression
multiple interactions
decreases activity
ISO
EXP
Tramadol affects the activity of CASP3 protein
Tramadol results in increased expression of CASP3 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of CASP3 protein]
Tramadol results in decreased activity of CASP3 protein
CTD PMID:27317026 PMID:28499616 PMID:31618080 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
JBrowse link
G Cat catalase decreases expression
multiple interactions
EXP Tramadol results in decreased expression of CAT mRNA; Tramadol results in decreased expression of CAT protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of CAT mRNA]
CTD PMID:25550769 PMID:31618080 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
JBrowse link
G Ckb creatine kinase B decreases expression
multiple interactions
ISO
EXP
Tramadol results in decreased expression of CKB mRNA
Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein]
CTD PMID:27317026 PMID:33645892 NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:136,549,844...136,553,478
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Ethanol promotes the reaction [Tramadol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol promotes the reaction [Ethanol results in increased expression of [CKM protein binds to CKB protein]]; Tramadol results in increased expression of [CKM protein binds to CKB protein] CTD PMID:33645892 NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation EXP tramadol increases phosphorylation of Creb1 protein in Prefrontal Cortex and nucleus accumbens RGD PMID:30632799 RGD:401901180 NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO Tramadol results in decreased activity of CYP17A1 protein CTD PMID:29100959 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:255,476,861...255,482,974
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases response to substance
affects metabolic processing
decreases response to substance
affects response to substance
multiple interactions
decreases methylation
increases metabolic processing
affects methylation
ISO CYP2D6 gene mutant form results in increased susceptibility to Tramadol
CYP2D6 gene mutant form affects the metabolism of Tramadol; CYP2D6 gene polymorphism affects the metabolism of Tramadol
CYP2D6 gene polymorphism results in decreased susceptibility to Tramadol
CYP2D6 affects the susceptibility to Tramadol; CYP2D6 gene polymorphism affects the susceptibility to Tramadol; CYP2D6 protein affects the susceptibility to Tramadol
[CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol] which results in increased chemical synthesis of O-demethyltramadol; CYP2D6 gene polymorphism affects the metabolism of and affects the susceptibility to Tramadol; CYP2D6 protein results in increased metabolism of and results in increased activity of Tramadol
CYP2D6 protein results in decreased methylation of Tramadol
CYP2D6 gene mutant form results in increased metabolism of Tramadol; CYP2D6 protein results in increased metabolism of Tramadol
CYP2D6 protein affects the methylation of Tramadol
CTD PMID:12191703 PMID:12893130 PMID:14624403 PMID:16497087 PMID:16960721 More... NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:115,761,696...115,771,837
JBrowse link
G Des desmin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of DES protein] CTD PMID:33645892 NCBI chr 9:84,299,626...84,307,344
Ensembl chr 9:84,298,447...84,307,347
JBrowse link
G Drd2 dopamine receptor D2 increases expression EXP Tramadol results in increased expression of DRD2 protein CTD PMID:15464068 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Tramadol results in increased expression of DRD3 protein CTD PMID:15464068 NCBI chr11:70,385,586...70,437,793
Ensembl chr11:70,385,586...70,446,760
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Tramadol increases expression of Fosb protein in Prefrontal Cortex and nucleus accumbens RGD PMID:30632799 RGD:401901180 NCBI chr 1:88,082,324...88,089,506
Ensembl chr 1:88,082,127...88,089,477
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of GJA1 protein] CTD PMID:33645892 NCBI chr20:36,302,490...36,315,010
Ensembl chr20:36,302,352...36,319,689
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 increases expression
multiple interactions
EXP Tramadol results in increased expression of GOT1 protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GOT1 protein]
CTD PMID:31618080 NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:252,284,434...252,329,871
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
increases expression
EXP Tramadol results in increased activity of GPT protein
Vitamin E inhibits the reaction [Tramadol results in increased expression of GPT protein]
CTD PMID:28689766 PMID:31618080 NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
increases expression
increases activity
EXP Ketanserin inhibits the reaction [Tramadol results in increased activity of HTR2A protein]
Tramadol results in increased expression of HTR2A mRNA
CTD PMID:18417104 NCBI chr15:56,360,647...56,428,703
Ensembl chr15:56,359,596...56,431,619
JBrowse link
G Ifng interferon gamma multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of IFNG protein] CTD PMID:33645892 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
JBrowse link
G Ldha lactate dehydrogenase A decreases expression ISO Tramadol results in decreased expression of LDHA mRNA CTD PMID:27317026 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:106,502,182...106,517,521
JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression ISO Tramadol results in decreased expression of NDUFS1 mRNA CTD PMID:27317026 NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:72,040,090...72,073,605
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding
multiple interactions
EXP Tramadol binds to OPRD1 protein
[Tramadol binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRD1 protein] which results in decreased uptake of Serotonin
CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding
EXP [Tramadol binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Tramadol binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Tramadol binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Pdk3 pyruvate dehydrogenase kinase 3 increases expression ISO Tramadol results in increased expression of PDK3 mRNA CTD PMID:27317026 NCBI chr  X:58,486,699...58,553,533
Ensembl chr  X:62,480,535...62,547,371
JBrowse link
G Pdyn prodynorphin decreases expression EXP Tramadol results in decreased expression of PDYN mRNA CTD PMID:17401159 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA1 mRNA CTD PMID:31276069 NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:55,967,351...56,003,450
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions EXP [Tiletamine co-treated with Xylazine co-treated with Tramadol] results in increased expression of PRKAA2 mRNA CTD PMID:31276069 NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:125,042,179...125,108,324
JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions EXP Naloxone inhibits the reaction [Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein]]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; Tramadol inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 protein] CTD PMID:11723065 NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Tramadol inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Tramadol inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
multiple interactions
EXP Tramadol results in decreased expression of SOD1 mRNA; Tramadol results in decreased expression of SOD1 protein
Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD1 mRNA]
CTD PMID:25550769 PMID:31618080 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP Tramadol deficiency inhibits the reaction [Tramadol results in increased expression of SOD2 mRNA]
Tramadol results in decreased expression of SOD2 mRNA
CTD PMID:25550769 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions
increases expression
EXP Ethanol promotes the reaction [Tramadol results in increased expression of SPP1 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of SPP1 protein] CTD PMID:33645892 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP [Acetaminophen co-treated with Tramadol] inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Tramadol results in increased expression of TNF protein] CTD PMID:17377112 PMID:31618080 PMID:33645892 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
JBrowse link
G Tnni3 troponin I3, cardiac type increases expression
multiple interactions
EXP Tramadol results in increased expression of TNNI3 protein
Ethanol promotes the reaction [Tramadol results in increased expression of TNNI3 protein]; Tramadol promotes the reaction [Ethanol results in increased expression of TNNI3 protein]
CTD PMID:33645892 NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:78,342,592...78,346,253
JBrowse link
G Vim vimentin multiple interactions EXP Tramadol promotes the reaction [Ethanol results in increased expression of VIM protein] CTD PMID:33645892 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746
JBrowse link
U50488 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grpr gastrin releasing peptide receptor increases phosphorylation
multiple interactions
ISO 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased phosphorylation of GRPR protein
bisindolylmaleimide inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased phosphorylation of GRPR protein]
CTD PMID:29669290 NCBI chr  X:34,630,238...34,670,245
Ensembl chr  X:34,630,229...34,670,245
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
increases activity
affects response to substance
ISO 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein; [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein] which results in increased phosphorylation of STAT3 protein
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer results in increased activity of OPRK1 protein
OPRK1 protein affects the susceptibility to 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein; 7-hydroxymitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]; mitragynine inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein]
CTD PMID:18385270 PMID:27192616 PMID:27231154 PMID:29669290 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Prkcd protein kinase C, delta multiple interactions
affects localization
ISO 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer affects the localization of PRKCD protein] CTD PMID:29669290 NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,775,681...5,805,839
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer binds to and results in increased activity of OPRK1 protein] which results in increased phosphorylation of STAT3 protein CTD PMID:18385270 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
JBrowse link
U69593 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO U 69593 results in increased phosphorylation of MAPK1 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK1 protein]
CTD PMID:16954126 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO U 69593 results in increased phosphorylation of MAPK3 protein
norbinaltorphimine inhibits the reaction [U 69593 results in increased phosphorylation of MAPK3 protein]
CTD PMID:16954126 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
JBrowse link
G Oprd1 opioid receptor, delta 1 affects binding EXP U 69593 binds to OPRD1 protein CTD PMID:7562497 NCBI chr 5:144,306,188...144,340,960
Ensembl chr 5:149,590,244...149,624,999
JBrowse link
G Oprk1 opioid receptor, kappa 1 affects binding
multiple interactions
EXP
ISO
U 69593 binds to OPRK1 protein
Buprenorphine inhibits the reaction [U 69593 binds to OPRK1 protein]; U 69593 binds to and results in increased activity of OPRK1 protein
[U 69593 binds to and results in increased activity of OPRK1 protein] inhibits the reaction [Cocaine affects the abundance of Dopamine]; U 69593 binds to and results in increased activity of OPRK1 protein
CTD PMID:7562497 PMID:11113311 PMID:15456805 PMID:21866885 PMID:21958337 NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:18,657,871...18,675,671
JBrowse link
G Oprm1 opioid receptor, mu 1 affects binding EXP U 69593 binds to OPRM1 protein CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:45,565,371...45,638,756
JBrowse link
G Pdyn prodynorphin multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PDYN mRNA] CTD PMID:11532335 NCBI chr 3:137,354,161...137,366,503
Ensembl chr 3:137,354,161...137,366,503
JBrowse link
G Penk proenkephalin multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of PENK mRNA] CTD PMID:11532335 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:21,981,382...21,986,705
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP U 69593 inhibits the reaction [Dextroamphetamine results in increased expression of TAC1 mRNA] CTD PMID:11532335 NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:36,645,571...36,653,546
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      biological role 20818
        pharmacological role 19911
          neurotransmitter agent 16947
            opioid agent 818
              delta-opioid agent + 65
              kappa-opioid agent + 56
              mu-opioid agent + 812
              opioid receptor agonist + 789
              opioid receptor antagonist + 112
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Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            neurotransmitter agent 16947
              opioid agent 818
                delta-opioid agent + 65
                kappa-opioid agent + 56
                mu-opioid agent + 812
                opioid receptor agonist + 789
                opioid receptor antagonist + 112
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