CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: phenoxy herbicide
Accession: CHEBI:60575
browse the term
Definition: Any member of the class of herbicides whose members contain a phenoxy or substituted phenoxy group.
Synonyms: related_synonym: phenoxy herbicides
xref: Wikipedia:Phenoxy_herbicide
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Abca7
ATP binding cassette subfamily A member 7
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCA7 mRNA
CTD
PMID:18579281
NCBI chr 7:9,691,452...9,711,466
Ensembl chr 7:9,691,449...9,711,425
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Abcb4
ATP binding cassette subfamily B member 4
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA
CTD
PMID:9210621
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc2
ATP binding cassette subfamily C member 2
increases expression multiple interactions
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 protein Alpha-Amanitin inhibits the reaction [2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ABCC2 mRNA]
CTD
PMID:10377250 PMID:16426233
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Acap3
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACAP3 mRNA
CTD
PMID:18579281
NCBI chr 5:166,500,781...166,515,477
Ensembl chr 5:166,500,781...166,515,481
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Acer2
alkaline ceramidase 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ACER2 mRNA
CTD
PMID:18579281
NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
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Adgrb2
adhesion G protein-coupled receptor B2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADGRB2 mRNA
CTD
PMID:18579281
NCBI chr 5:142,299,190...142,362,540
Ensembl chr 5:142,331,329...142,362,540
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Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ADH4 mRNA
CTD
PMID:18579281
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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Alpi
alkaline phosphatase, intestinal
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of ALPI mRNA
CTD
PMID:18579281
NCBI chr 9:87,773,411...87,776,877
Ensembl chr 9:87,773,411...87,776,877
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Ar
androgen receptor
affects binding
EXP
2,4,5-Trichlorophenoxyacetic Acid binds to AR protein
CTD
PMID:14565775
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Arhgap32
Rho GTPase activating protein 32
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARHGAP32 mRNA
CTD
PMID:18579281
NCBI chr 8:30,421,269...30,681,653
Ensembl chr 8:30,421,515...30,678,454
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Arsg
arylsulfatase G
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of ARSG mRNA
CTD
PMID:18579281
NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941
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Basp1
brain abundant, membrane attached signal protein 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of BASP1 mRNA
CTD
PMID:18579281
NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043
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C1qtnf4
C1q and TNF related 4
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of C1QTNF4 mRNA
CTD
PMID:18579281
NCBI chr 3:76,854,368...76,872,991
Ensembl chr 3:76,857,735...76,874,139
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Cacnb3
calcium voltage-gated channel auxiliary subunit beta 3
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CACNB3 mRNA
CTD
PMID:18579281
NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074
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Camk1d
calcium/calmodulin-dependent protein kinase ID
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CAMK1D mRNA
CTD
PMID:18579281
NCBI chr17:72,581,899...72,982,704
Ensembl chr17:72,581,979...72,980,556
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Capn6
calpain 6
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of CAPN6 mRNA
CTD
PMID:18579281
NCBI chr X:107,380,774...107,405,489
Ensembl chr X:107,380,774...107,405,489
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Cdh1
cadherin 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CDH1 mRNA
CTD
PMID:18579281
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cirbp
cold inducible RNA binding protein
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CIRBP mRNA
CTD
PMID:18579281
NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818
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Ckm
creatine kinase, M-type
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CKM mRNA
CTD
PMID:18579281
NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
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Clca4
chloride channel accessory 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of CLCA4A mRNA
CTD
PMID:18579281
NCBI chr 2:233,883,625...233,904,993
Ensembl chr 2:233,883,851...233,903,089
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Col15a1
collagen type XV alpha 1 chain
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of COL15A1 mRNA
CTD
PMID:18579281
NCBI chr 5:61,501,963...61,607,591
Ensembl chr 5:61,501,963...61,607,591
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Cyp7b1
cytochrome P450 family 7 subfamily B member 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of CYP7B1 mRNA
CTD
PMID:18579281
NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
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Ddc
dopa decarboxylase
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of DDC mRNA
CTD
PMID:18579281
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Eepd1
endonuclease/exonuclease/phosphatase family domain containing 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of EEPD1 mRNA
CTD
PMID:18579281
NCBI chr 8:23,957,258...24,064,343
Ensembl chr 8:23,957,255...24,064,340
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Ephx1
epoxide hydrolase 1
increases activity
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased activity of EPHX1 protein
CTD
PMID:3032197
NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
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Ephx2
epoxide hydrolase 2
multiple interactions
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of and results in increased activity of EPHX2 protein
CTD
PMID:3032197
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
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Esr1
estrogen receptor 1
multiple interactions
ISO
2,4,5-Trichlorophenoxyacetic Acid binds to and results in decreased activity of ESR1 protein
CTD
PMID:16626760
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Far1
fatty acyl CoA reductase 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FAR1 mRNA
CTD
PMID:18579281
NCBI chr 1:167,644,622...167,705,868
Ensembl chr 1:167,644,677...167,705,730
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Fkbp5
FKBP prolyl isomerase 5
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FKBP5 mRNA
CTD
PMID:18579281
NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674
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Fmo2
flavin containing dimethylaniline monoxygenase 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of FMO2 mRNA
CTD
PMID:18579281
NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
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G0s2
G0/G1switch 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of G0S2 mRNA
CTD
PMID:18579281
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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Gbf1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBF1 mRNA
CTD
PMID:18579281
NCBI chr 1:245,018,535...245,147,052
Ensembl chr 1:245,018,568...245,147,042
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Gbp6
guanylate binding protein family member 6
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GBP9 mRNA
CTD
PMID:18579281
NCBI chr14:4,730,286...4,756,508
Ensembl chr14:4,730,453...4,839,062
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Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNA
CTD
PMID:10377250 PMID:16426233
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gde1
glycerophosphodiester phosphodiesterase 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GDE1 mRNA
CTD
PMID:18579281
NCBI chr 1:173,016,984...173,032,396
Ensembl chr 1:172,954,394...173,032,429
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Gfra1
GDNF family receptor alpha 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GFRA1 mRNA
CTD
PMID:18579281
NCBI chr 1:257,315,682...257,552,004
Ensembl chr 1:257,321,742...257,551,473
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Git2
GIT ArfGAP 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GIT2 mRNA
CTD
PMID:18579281
NCBI chr12:41,829,717...41,872,621
Ensembl chr12:41,829,730...41,871,097
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Gmppb
GDP-mannose pyrophosphorylase B
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GMPPB mRNA
CTD
PMID:18579281
NCBI chr 8:108,737,429...108,767,286
Ensembl chr 8:108,693,060...108,767,286
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Got1
glutamic-oxaloacetic transaminase 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GOT1 mRNA
CTD
PMID:18579281
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpm6a
glycoprotein m6a
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPM6A mRNA
CTD
PMID:18579281
NCBI chr16:36,641,282...36,973,477
Ensembl chr16:36,641,284...36,973,475
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Gpr12
G protein-coupled receptor 12
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of GPR12 mRNA
CTD
PMID:18579281
NCBI chr12:8,522,709...8,525,875
Ensembl chr12:8,522,953...8,527,973
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Gpr85
G protein-coupled receptor 85
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of GPR85 mRNA
CTD
PMID:18579281
NCBI chr 4:42,100,138...42,109,584
Ensembl chr 4:42,102,941...42,109,566
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Hapln1
hyaluronan and proteoglycan link protein 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HAPLN1 mRNA
CTD
PMID:18579281
NCBI chr 2:20,631,640...20,696,388
Ensembl chr 2:20,631,640...20,693,777
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Hmox1
heme oxygenase 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HMOX1 mRNA
CTD
PMID:18579281
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa8
heat shock protein family A (Hsp70) member 8
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPA8 mRNA
CTD
PMID:18579281
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
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Hspb1
heat shock protein family B (small) member 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPB1 mRNA
CTD
PMID:18579281
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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Hsph1
heat shock protein family H (Hsp110) member 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of HSPH1 mRNA
CTD
PMID:18579281
NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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Ido2
indoleamine 2,3-dioxygenase 2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IDO2 mRNA
CTD
PMID:18579281
NCBI chr16:67,459,158...67,498,052
Ensembl chr16:67,459,190...67,496,324
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Ihh
Indian hedgehog signaling molecule
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IHH mRNA
CTD
PMID:18579281
NCBI chr 9:76,504,315...76,510,532
Ensembl chr 9:76,504,315...76,510,532
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Ikbke
inhibitor of nuclear factor kappa B kinase subunit epsilon
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of IKBKE mRNA
CTD
PMID:18579281
NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
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Il1r1
interleukin 1 receptor type 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of IL1R1 mRNA
CTD
PMID:18579281
NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
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Insc
INSC, spindle orientation adaptor protein
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of INSC mRNA
CTD
PMID:18579281
NCBI chr 1:168,993,032...169,100,438
Ensembl chr 1:168,993,032...169,100,433
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Klf5
KLF transcription factor 5
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of KLF5 mRNA
CTD
PMID:18579281
NCBI chr15:76,060,320...76,079,445
Ensembl chr15:76,064,258...76,079,445
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Limch1
LIM and calponin homology domains 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LIMCH1 mRNA
CTD
PMID:18579281
NCBI chr14:41,112,579...41,425,185
Ensembl chr14:41,114,803...41,425,191
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Lmcd1
LIM and cysteine-rich domains 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LMCD1 mRNA
CTD
PMID:18579281
NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
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Lpar4
lysophosphatidic acid receptor 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPAR4 mRNA
CTD
PMID:18579281
NCBI chr X:72,033,486...72,046,978
Ensembl chr X:72,033,486...72,046,977
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Lpin1
lipin 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of LPIN1 mRNA
CTD
PMID:18579281
NCBI chr 6:39,309,198...39,417,034
Ensembl chr 6:39,312,748...39,417,097
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Lrtm1
leucine-rich repeats and transmembrane domains 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of LRTM1 mRNA
CTD
PMID:18579281
NCBI chr16:4,210,343...4,217,843
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Matk
megakaryocyte-associated tyrosine kinase
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MATK mRNA
CTD
PMID:18579281
NCBI chr 7:8,456,990...8,465,947
Ensembl chr 7:8,456,998...8,462,022
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Mpdz
multiple PDZ domain crumbs cell polarity complex component
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MPDZ mRNA
CTD
PMID:18579281
NCBI chr 5:95,766,112...95,920,531
Ensembl chr 5:95,766,118...95,920,499
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Mt4
metallothionein 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of MT4 mRNA
CTD
PMID:18579281
NCBI chr19:10,863,813...10,865,909
Ensembl chr19:10,863,813...10,865,909
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Mvd
mevalonate diphosphate decarboxylase
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MVD mRNA
CTD
PMID:18579281
NCBI chr19:50,496,366...50,506,389
Ensembl chr19:50,496,367...50,507,971
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Mybph
myosin binding protein H
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of MYBPH mRNA
CTD
PMID:18579281
NCBI chr13:45,653,156...45,660,893
Ensembl chr13:45,653,234...45,660,893
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Ndrg4
NDRG family member 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NDRG4 mRNA
CTD
PMID:18579281
NCBI chr19:9,351,408...9,387,398
Ensembl chr19:9,351,404...9,386,914
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Nip7
nucleolar pre-rRNA processing protein NIP7
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NIP7 mRNA
CTD
PMID:18579281
NCBI chr19:34,962,557...34,964,700
Ensembl chr19:34,962,557...34,964,711
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Nrg4
neuregulin 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of NRG4 mRNA
CTD
PMID:18579281
NCBI chr 8:55,586,253...55,677,829
Ensembl chr 8:55,592,893...55,677,483
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Ogn
osteoglycin
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of OGN mRNA
CTD
PMID:18579281
NCBI chr17:15,032,069...15,052,626
Ensembl chr17:15,032,069...15,052,739
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Or5b99
olfactory receptor family 5 subfamily B member 99
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of OR5B99 mRNA
CTD
PMID:18579281
NCBI chr 1:210,136,841...210,137,767
Ensembl chr 1:210,132,946...210,138,365
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Pfkp
phosphofructokinase, platelet
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PFKP mRNA
CTD
PMID:18579281
NCBI chr17:63,729,743...63,794,021
Ensembl chr17:63,729,780...63,794,018
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Plin4
perilipin 4
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PLIN4 mRNA
CTD
PMID:18579281
NCBI chr 9:929,168...938,062
Ensembl chr 9:929,176...938,056
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Por
cytochrome p450 oxidoreductase
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of POR mRNA
CTD
PMID:18579281
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ppfibp1
PPFIA binding protein 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPFIBP1 mRNA
CTD
PMID:18579281
NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
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Ppp1r3a
protein phosphatase 1, regulatory subunit 3A
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3A mRNA
CTD
PMID:18579281
NCBI chr 4:42,937,353...42,980,195
Ensembl chr 4:42,939,599...42,980,638
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Ppp1r3g
protein phosphatase 1, regulatory subunit 3G
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PPP1R3G mRNA
CTD
PMID:18579281
NCBI chr17:28,874,956...28,878,288
Ensembl chr17:28,876,482...28,877,525
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Prok1
prokineticin 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of PROK1 mRNA
CTD
PMID:18579281
NCBI chr 2:194,853,991...194,859,250
Ensembl chr 2:194,853,991...194,859,250
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Prr9
proline rich 9
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PRR9 mRNA
CTD
PMID:18579281
NCBI chr 2:177,599,483...177,600,849
Ensembl chr 2:177,599,483...177,600,849
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Ptp4a1
protein tyrosine phosphatase 4A1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of PTP4A1 mRNA
CTD
PMID:18579281
NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
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Retreg1
reticulophagy regulator 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RETREG1 mRNA
CTD
PMID:18579281
NCBI chr 2:76,335,609...76,474,817
Ensembl chr 2:76,335,609...76,493,898
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Rprd1a
regulation of nuclear pre-mRNA domain containing 1A
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of RPRD1A mRNA
CTD
PMID:18579281
NCBI chr18:15,791,418...15,839,338
Ensembl chr18:15,791,418...15,839,338
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Selenop
selenoprotein P
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SELENOP mRNA
CTD
PMID:18579281
NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
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Sema3c
semaphorin 3C
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SEMA3C mRNA
CTD
PMID:18579281
NCBI chr 4:17,583,212...17,747,234
Ensembl chr 4:17,583,212...17,746,534
G
Sgk2
serum/glucocorticoid regulated kinase 2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SGK2 mRNA
CTD
PMID:18579281
NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
G
Slc24a2
solute carrier family 24 member 2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC24A2 mRNA
CTD
PMID:18579281
NCBI chr 5:101,499,536...101,739,337
Ensembl chr 5:101,502,278...101,739,337
G
Slc25a32
solute carrier family 25 member 32
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC25A32 mRNA
CTD
PMID:18579281
NCBI chr 7:70,142,958...70,160,726
Ensembl chr 7:70,142,964...70,160,770
G
Slc66a1
solute carrier family 66 member 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SLC66A1 mRNA
CTD
PMID:18579281
NCBI chr 5:151,537,870...151,552,338
Ensembl chr 5:151,542,376...151,552,259
G
Slc6a15
solute carrier family 6 member 15
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of SLC6A15 mRNA
CTD
PMID:18579281
NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239
G
Snx7
sorting nexin 7
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SNX7 mRNA
CTD
PMID:18579281
NCBI chr 2:205,843,164...205,927,737
Ensembl chr 2:205,842,837...205,927,763
G
Spon2
spondin 2
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SPON2 mRNA
CTD
PMID:18579281
NCBI chr14:77,505,695...77,518,001
Ensembl chr14:77,511,901...77,517,996
G
Srebf1
sterol regulatory element binding transcription factor 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SREBF1 mRNA
CTD
PMID:18579281
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
G
Svil
supervillin
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of SVIL mRNA
CTD
PMID:18579281
NCBI chr17:52,648,502...52,844,114
Ensembl chr17:52,648,502...52,793,404
G
Tacc2
transforming, acidic coiled-coil containing protein 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TACC2 mRNA
CTD
PMID:18579281
NCBI chr 1:185,139,223...185,327,881
Ensembl chr 1:185,116,111...185,327,881
G
Tbc1d8
TBC1 domain family, member 8
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TBC1D8 mRNA
CTD
PMID:18579281
NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409
G
Tcea2
transcription elongation factor A2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TCEA2 mRNA
CTD
PMID:18579281
NCBI chr 3:168,796,244...168,804,125
Ensembl chr 3:168,796,331...168,804,116
G
Thra
thyroid hormone receptor alpha
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of THRA mRNA
CTD
PMID:18579281
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
G
Thrb
thyroid hormone receptor beta
affects binding
ISO
2,4,5-Trichlorophenoxyacetic Acid binds to THRB protein
CTD
PMID:27410513
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Tom1l2
target of myb1 like 2 membrane trafficking protein
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TOM1L2 mRNA
CTD
PMID:18579281
NCBI chr10:45,036,034...45,158,168
Ensembl chr10:45,036,035...45,158,032
G
Trib3
tribbles pseudokinase 3
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TRIB3 mRNA
CTD
PMID:18579281
NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
G
Tril
TLR4 interactor with leucine-rich repeats
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of TRIL mRNA
CTD
PMID:18579281
NCBI chr 4:82,922,327...82,927,172
Ensembl chr 4:82,922,328...82,927,172
G
Tsc22d1
TSC22 domain family, member 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of TSC22D1 mRNA
CTD
PMID:18579281
NCBI chr15:51,750,489...51,850,958
Ensembl chr15:51,749,510...51,850,958
G
Ugt2a3
UDP glucuronosyltransferase family 2 member A3
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of UGT2A3 mRNA
CTD
PMID:18579281
NCBI chr14:20,572,825...20,590,295
Ensembl chr14:20,572,808...20,590,729
G
Usp2
ubiquitin specific peptidase 2
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of USP2 mRNA
CTD
PMID:18579281
NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
G
Vamp1
vesicle-associated membrane protein 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of VAMP1 mRNA
CTD
PMID:18579281
NCBI chr 4:158,012,634...158,019,350
Ensembl chr 4:158,012,663...158,019,349
G
Vcam1
vascular cell adhesion molecule 1
decreases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in decreased expression of VCAM1 mRNA
CTD
PMID:18579281
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
G
Veph1
ventricular zone expressed PH domain-containing 1
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of VEPH1 mRNA
CTD
PMID:18579281
NCBI chr 2:150,291,379...150,537,491
Ensembl chr 2:150,296,573...150,537,266
G
Wars2
tryptophanyl tRNA synthetase 2 (mitochondrial)
increases expression
ISO
2,4,5-Trichlorophenoxyacetic Acid results in increased expression of WARS2 mRNA
CTD
PMID:18579281
NCBI chr 2:186,459,744...186,543,581
Ensembl chr 2:186,459,444...186,543,571
G
Clcnka
chloride voltage-gated channel Ka
decreases activity
EXP
2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKA protein
CTD
PMID:15167890
NCBI chr 5:153,691,208...153,706,295
Ensembl chr 5:153,691,209...153,706,148
G
Clcnkb
chloride voltage-gated channel Kb
decreases activity
EXP
2-Methyl-4-chlorophenoxyacetic Acid analog results in decreased activity of CLCNKB protein
CTD
PMID:15167890
NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153
G
Slc1a2
solute carrier family 1 member 2
affects expression
EXP
2-Methyl-4-chlorophenoxyacetic Acid affects the expression of SLC1A2 protein
CTD
PMID:16019039
NCBI chr 3:89,005,129...89,126,498
Ensembl chr 3:89,005,129...89,126,498
G
Tnf
tumor necrosis factor
increases expression
ISO
2-Methyl-4-chlorophenoxyacetic Acid results in increased expression of TNF protein
CTD
PMID:10883730
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Abcb4
ATP binding cassette subfamily B member 4
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of ABCB4 mRNA
CTD
PMID:9210621
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
G
Alb
albumin
affects binding
ISO
2,4-Dichlorophenoxyacetic Acid binds to ALB protein
CTD
PMID:9877224 PMID:11451446
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Apaf1
apoptotic peptidase activating factor 1
multiple interactions decreases expression
ISO
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APAF1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in decreased expression of APAF1 protein 2,4-Dichlorophenoxyacetic Acid results in decreased expression of APAF1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of APAF1 protein
CTD
PMID:33865415
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
G
Ar
androgen receptor
multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [Androgens binds to AR protein]; 2,4-Dichlorophenoxyacetic Acid promotes the reaction [Dihydrotestosterone results in increased localization of and results in increased activity of AR protein]
CTD
PMID:16107550
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Axin2
axin 2
multiple interactions increases expression
ISO
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of AXIN2 mRNA 2,4-Dichlorophenoxyacetic Acid results in increased expression of AXIN2 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of AXIN2 protein
CTD
PMID:34463001
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
G
Becn1
beclin 1
multiple interactions decreases expression
EXP
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of BECN1 protein]
CTD
PMID:34464015
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
G
Casp1
caspase 1
decreases cleavage multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased cleavage of CASP1 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased cleavage of CASP1 protein]
CTD
PMID:34464015
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Ccdc120
coiled-coil domain containing 120
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CCDC120 mRNA
CTD
PMID:15878651
NCBI chr X:14,753,594...14,772,745
Ensembl chr X:14,753,696...14,772,743
G
Ccl11
C-C motif chemokine ligand 11
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL11 protein
CTD
PMID:19467290
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
G
Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL2 protein
CTD
PMID:19467290
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
G
Ccl4
C-C motif chemokine ligand 4
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CCL4 protein
CTD
PMID:19467290
NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
G
Cdk6
cyclin-dependent kinase 6
increases expression multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CDK6 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CDK6 protein [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of CDK6 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of CDK6 protein
CTD
PMID:33865415
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
G
Cldn1
claudin 1
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLDN1 protein
CTD
PMID:28699141
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
G
Clk1
CDC-like kinase 1
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CLK1 mRNA
CTD
PMID:15878651
NCBI chr 9:59,947,774...59,959,002
Ensembl chr 9:59,947,764...59,957,000
G
Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of CNP protein
CTD
PMID:18460445
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
G
Crat
carnitine O-acetyltransferase
increases activity
ISO
2,4-Dichlorophenoxyacetic Acid results in increased activity of CRAT protein
CTD
PMID:1755024
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
G
Creb1
cAMP responsive element binding protein 1
increases expression multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 protein PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA]
CTD
PMID:29633193
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
affects expression
ISO
2,4-Dichlorophenoxyacetic Acid affects the expression of CYP17A1 mRNA
CTD
PMID:26838045
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A1 mRNA
CTD
PMID:10910964
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1A2 mRNA
CTD
PMID:10910964
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of CYP1B1 mRNA
CTD
PMID:10910964
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Dbh
dopamine beta-hydroxylase
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of DBH protein
CTD
PMID:16931444
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
G
Dclre1c
DNA cross-link repair 1C
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of DCLRE1C mRNA
CTD
PMID:15878651
NCBI chr17:74,775,828...74,810,089
Ensembl chr17:74,776,935...74,809,186
G
Ddb2
damage specific DNA binding protein 2
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of DDB2 mRNA
CTD
PMID:15878651
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
G
Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of DDIT3 mRNA
CTD
PMID:34626751
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Ephx1
epoxide hydrolase 1
increases activity
ISO
2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX1 protein
CTD
PMID:3032197
NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
G
Ephx2
epoxide hydrolase 2
increases activity
ISO
2,4-Dichlorophenoxyacetic Acid results in increased activity of EPHX2 protein
CTD
PMID:1755024 PMID:3032197
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
G
Foxo1
forkhead box O1
multiple interactions increases expression
ISO
PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA] 2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 protein
CTD
PMID:29633193
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
G
Fth1
ferritin heavy chain 1
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of FTH1 mRNA
CTD
PMID:15878651
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
G
Ftl1
ferritin light chain 1
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of FTL mRNA
CTD
PMID:15878651
NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725
G
Gfap
glial fibrillary acidic protein
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of GFAP mRNA
CTD
PMID:22954530
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCR
CTD
PMID:26838045
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of HMGCS1
CTD
PMID:26838045
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
G
Ifng
interferon gamma
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IFNG
CTD
PMID:20728597
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il18
interleukin 18
increases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL18 protein]
CTD
PMID:34464015
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
increases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of IL1B protein]
CTD
PMID:34464015
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1rl1
interleukin 1 receptor-like 1
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of IL1RL1 mRNA
CTD
PMID:15878651
NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256
G
Il2
interleukin 2
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2
CTD
PMID:20728597
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il2ra
interleukin 2 receptor subunit alpha
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL2RA
CTD
PMID:20728597
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
G
Il4
interleukin 4
increases expression increases secretion
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL4 protein 2,4-Dichlorophenoxyacetic Acid results in increased secretion of IL4 protein
CTD
PMID:19467290
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il5
interleukin 5
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL5 protein
CTD
PMID:19467290
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
G
Il6
interleukin 6
increases expression
ISO EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of IL6 protein
CTD
PMID:19467290 PMID:34464015
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Itgb1
integrin subunit beta 1
increases expression multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of ITGB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of ITGB1 protein [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of ITGB1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of ITGB1 protein
CTD
PMID:33865415
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Ldha
lactate dehydrogenase A
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of LDHA protein
CTD
PMID:23538319
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
decreases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in decreased expression of MAP1LC3B mRNA]
CTD
PMID:34464015
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
G
Mbp
myelin basic protein
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of MBP protein
CTD
PMID:18460445
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
G
Myc
MYC proto-oncogene, bHLH transcription factor
decreases methylation
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased methylation of MYC promoter
CTD
PMID:11857776
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions increases expression
ISO
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of NFKB1 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of NFKB1 protein 2,4-Dichlorophenoxyacetic Acid results in increased expression of NFKB1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of NFKB1 protein
CTD
PMID:33865415
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
G
Nlrp3
NLR family, pyrin domain containing 3
increases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of NLRP3 protein]
CTD
PMID:34464015
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Ocln
occludin
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of OCLN mRNA
CTD
PMID:28699141
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
G
Oxt
oxytocin/neurophysin I prepropeptide
decreases secretion
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased secretion of OXT protein
CTD
PMID:20122984
NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
G
Pcna
proliferating cell nuclear antigen
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of PCNA mRNA
CTD
PMID:15878651
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Pfkm
phosphofructokinase, muscle
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of PFKM protein
CTD
PMID:23538319
NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192
G
Ppara
peroxisome proliferator activated receptor alpha
increases response to substance
ISO
PPARA protein results in increased susceptibility to 2,4-Dichlorophenoxyacetic Acid
CTD
PMID:26838045
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
G
Ppard
peroxisome proliferator-activated receptor delta
multiple interactions increases expression
ISO
PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of CREB1 mRNA]; PPARB protein affects the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of FOXO1 mRNA] 2,4-Dichlorophenoxyacetic Acid results in increased expression of PPARB mRNA
CTD
PMID:29633193
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
G
Prl
prolactin
decreases secretion
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased secretion of PRL protein
CTD
PMID:20122984
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
G
Ptger3
prostaglandin E receptor 3
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of PTGER3 mRNA
CTD
PMID:15878651
NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
G
Pycard
PYD and CARD domain containing
increases expression multiple interactions
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of PYCARD protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of PYCARD protein]
CTD
PMID:34464015
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
G
Slc16a3
solute carrier family 16 member 3
decreases expression increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC16A3 mRNA 2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC16A3 mRNA
CTD
PMID:23538319
NCBI chr10:106,212,679...106,222,564
Ensembl chr10:106,212,778...106,222,562
G
Slc22a12
solute carrier family 22 member 12
multiple interactions
ISO
Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]
CTD
PMID:15284287
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
G
Slc22a20
solute carrier family 22 member 20
multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate]
CTD
PMID:16478971
NCBI chr 1:203,257,374...203,273,848
Ensembl chr 1:203,257,374...203,273,822
G
Slc22a25
solute carrier family 22, member 25
multiple interactions
ISO
2,4-Dichlorophenoxyacetic Acid inhibits the reaction [SLC22A19 protein results in increased uptake of ochratoxin A]
CTD
PMID:15068970
NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
G
Slc22a6
solute carrier family 22 member 6
increases uptake multiple interactions
EXP ISO
SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of 2,4-Dichlorophenoxyacetic Acid]
CTD
PMID:16857889 PMID:17255469
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
G
Slc2a3
solute carrier family 2 member 3
decreases expression increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of SLC2A3 protein 2,4-Dichlorophenoxyacetic Acid results in increased expression of SLC2A3 mRNA
CTD
PMID:23538319
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
G
Sqstm1
sequestosome 1
multiple interactions increases expression
EXP
lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA]; lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein] 2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of SQSTM1 protein
CTD
PMID:34464015
NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
G
Srxn1
sulfiredoxin 1
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of SRXN1 mRNA
CTD
PMID:34626751
NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
G
Th
tyrosine hydroxylase
increases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of TH protein
CTD
PMID:16931444
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
G
Thrb
thyroid hormone receptor beta
affects binding
ISO
2,4-Dichlorophenoxyacetic Acid binds to THRB protein
CTD
PMID:27410513
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
G
Tjp1
tight junction protein 1
decreases expression
EXP
2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 mRNA; 2,4-Dichlorophenoxyacetic Acid results in decreased expression of TJP1 protein
CTD
PMID:28699141
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
G
Tnf
tumor necrosis factor
increases expression multiple interactions
ISO EXP
2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF 2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein lycium barbarum polysaccharide inhibits the reaction [2,4-Dichlorophenoxyacetic Acid results in increased expression of TNF protein]
CTD
PMID:20728597 PMID:34464015
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
multiple interactions increases expression
ISO
[Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of TRP53 mRNA; [Lipopolysaccharides co-treated with 2,4-Dichlorophenoxyacetic Acid] results in increased expression of TRP53 protein 2,4-Dichlorophenoxyacetic Acid results in increased expression of TRP53 mRNA; 2,4-Dichlorophenoxyacetic Acid results in increased expression of TRP53 protein
CTD
PMID:33865415
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Usp19
ubiquitin specific peptidase 19
increases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in increased expression of USP19 mRNA
CTD
PMID:15878651
NCBI chr 8:109,190,727...109,201,761
Ensembl chr 8:109,190,724...109,201,741
G
Vegfa
vascular endothelial growth factor A
decreases expression
ISO
2,4-Dichlorophenoxyacetic Acid results in decreased expression of VEGFA mRNA
CTD
PMID:15878651
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Lep
leptin
multiple interactions
EXP
[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of LEP protein
CTD
PMID:29321614
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
G
Lepr
leptin receptor
multiple interactions
EXP
[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of LEPR mRNA
CTD
PMID:29321614
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Nmb
neuromedin B
multiple interactions
EXP
[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in decreased expression of NMB mRNA
CTD
PMID:29321614
NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190
G
Nmbr
neuromedin B receptor
multiple interactions
EXP
[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NMBR mRNA
CTD
PMID:29321614
NCBI chr 1:9,115,033...9,146,081
Ensembl chr 1:9,134,889...9,145,462
G
Npy1r
neuropeptide Y receptor Y1
multiple interactions
EXP
[2-amino-3-chloro-1,4-naphthoquinone co-treated with Ziram co-treated with cyromazine co-treated with 2-methyl-4-chlorophenoxy gamma-butyric acid co-treated with pirimicarb co-treated with Thiram] results in increased expression of NPY1R mRNA
CTD
PMID:29321614
NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759
G
Aadac
arylacetamide deacetylase
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of AADAC mRNA
CTD
PMID:16197558
NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
G
Abhd3
abhydrolase domain containing 3, phospholipase
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of ABHD3 mRNA
CTD
PMID:16197558
NCBI chr18:1,723,203...1,778,488
Ensembl chr18:1,720,718...1,803,428
G
Acadm
acyl-CoA dehydrogenase medium chain
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of ACADM mRNA
CTD
PMID:16197558
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
G
Acadvl
acyl-CoA dehydrogenase, very long chain
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of ACADVL mRNA
CTD
PMID:16197558
NCBI chr10:54,732,875...54,738,102
Ensembl chr10:54,732,469...54,738,075
G
Acsl1
acyl-CoA synthetase long-chain family member 1
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of ACSL1 mRNA
CTD
PMID:16197558
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
fenofibric acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]
CTD
PMID:18513333
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
G
Adipor1
adiponectin receptor 1
decreases expression
ISO
fenofibric acid results in decreased expression of ADIPOR1 protein
CTD
PMID:16023994
NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241
G
Akr1b1
aldo-keto reductase family 1 member B1
increases reduction
ISO
AKR1B1 protein results in increased reduction of fenofibric acid
CTD
PMID:27599626
NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157
G
Akr1b10
aldo-keto reductase family 1 member B10
multiple interactions decreases activity
ISO
fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; fenofibric acid inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde] fenofibric acid results in decreased activity of AKR1B10 protein; fenofibric acid results in decreased activity of AKR1B10 protein mutant form
CTD
PMID:18325492 PMID:19028477
NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852
G
Akr1c1
aldo-keto reductase family 1, member C1
increases reduction
ISO
AKR1C1 protein results in increased reduction of fenofibric acid
CTD
PMID:27599626
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
G
Akr1c2
aldo-keto reductase family 1, member C2
increases reduction
ISO
AKR1C2 protein results in increased reduction of fenofibric acid
CTD
PMID:27599626
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
G
Akr1c3
aldo-keto reductase family 1, member C3
increases reduction
ISO
AKR1C3 protein results in increased reduction of fenofibric acid
CTD
PMID:27599626
NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
G
Angptl4
angiopoietin-like 4
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of ANGPTL4 mRNA
CTD
PMID:16197558
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
G
Apoa1
apolipoprotein A1
multiple interactions decreases expression
EXP
[fenofibric acid co-treated with Dexamethasone] results in increased expression of APOA1 mRNA; [fenofibric acid co-treated with Tretinoin] results in increased expression of APOA1 mRNA; fenofibric acid inhibits the reaction [Dexamethasone results in increased expression of APOA1 mRNA]; fenofibric acid inhibits the reaction [Tretinoin results in increased expression of APOA1 mRNA] fenofibric acid results in decreased expression of APOA1 mRNA
CTD
PMID:7556148
NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
G
Apoa2
apolipoprotein A2
decreases expression
EXP
fenofibric acid results in decreased expression of APOA2 mRNA
CTD
PMID:7556148
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
G
Aqp3
aquaporin 3 (Gill blood group)
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of AQP3 mRNA
CTD
PMID:16197558
NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720
G
Ascc1
activating signal cointegrator 1 complex subunit 1
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of ASCC1 mRNA
CTD
PMID:16197558
NCBI chr20:27,941,053...28,031,272
Ensembl chr20:27,941,283...28,031,272
G
Cat
catalase
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of CAT mRNA
CTD
PMID:16197558
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Cbr1
carbonyl reductase 1
increases reduction
ISO
CBR1 protein results in increased reduction of fenofibric acid
CTD
PMID:27599626
NCBI chr11:32,876,563...32,884,234
G
Cebpa
CCAAT/enhancer binding protein alpha
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of CEBPA mRNA
CTD
PMID:16197558
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
G
Col1a1
collagen type I alpha 1 chain
multiple interactions
EXP
fenofibric acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]
CTD
PMID:18513333
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
G
Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of CPT1A mRNA
CTD
PMID:16197558
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
G
Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
increases activity increases expression
ISO
fenofibric acid results in increased activity of CYP2C8 protein fenofibric acid results in increased expression of CYP2C8 mRNA; fenofibric acid results in increased expression of CYP2C8 protein
CTD
PMID:15771232
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases activity increases expression
ISO
fenofibric acid results in increased activity of CYP3A4 protein fenofibric acid results in increased expression of CYP3A4 mRNA
CTD
PMID:15771232
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
G
Fabp1
fatty acid binding protein 1
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of FABP1 mRNA
CTD
PMID:16197558
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
G
Fn1
fibronectin 1
multiple interactions
EXP
fenofibric acid inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]
CTD
PMID:18513333
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
G
Gng12
G protein subunit gamma 12
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of GNG12 mRNA
CTD
PMID:16197558
NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of HADHA mRNA
CTD
PMID:16197558
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of HADHB mRNA
CTD
PMID:16197558
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of HMGCS2 mRNA
CTD
PMID:16197558
NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130
G
Hmox1
heme oxygenase 1
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of HMOX1 mRNA
CTD
PMID:16197558
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Id2
inhibitor of DNA binding 2
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of ID2 mRNA
CTD
PMID:16197558
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
G
Isca1
iron-sulfur cluster assembly 1
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of ISCA1 mRNA
CTD
PMID:16197558
NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955
G
Pck1
phosphoenolpyruvate carboxykinase 1
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of PCK1 mRNA
CTD
PMID:16197558
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
G
Pdzk1
PDZ domain containing 1
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of PDZK1 mRNA
CTD
PMID:16197558
NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514
G
Plin2
perilipin 2
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of PLIN2 mRNA
CTD
PMID:16197558
NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
G
Ppara
peroxisome proliferator activated receptor alpha
affects binding multiple interactions increases expression increases activity
ISO
fenofibric acid binds to PPARA protein [fenofibric acid binds to PPARA protein] which results in increased expression of AADAC mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of ABHD3 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of ACADM mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of ACADVL mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of ACSL1 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of ANGPTL4 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of AQP3 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of ASCC1 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of CAT mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of CEBPA mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of CPT1A mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of FABP1 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of GNG12 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of HADHA mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of HADHB mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of HMGCS2 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of HMOX1 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of ID2 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of ISCA1 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of PCK1 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of PDZK1 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of PLIN2 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of SERPINE1 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of SLC16A1 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of SLC25A20 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of TMEM53 mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of TXNIP mRNA; [fenofibric acid binds to PPARA protein] which results in increased expression of VNN1 mRNA; fenofibric acid results in increased activity of [PPARA protein binds to RXRA protein]; PPARA protein affects the reaction [fenofibric acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]] fenofibric acid results in increased expression of PPARA mRNA fenofibric acid results in increased activity of PPARA protein
CTD
PMID:11779144 PMID:15273253 PMID:16197558 PMID:16680075 PMID:17360982
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
G
Ppard
peroxisome proliferator-activated receptor delta
multiple interactions
ISO
fenofibric acid results in increased activity of [PPARD protein binds to RXRA protein]
CTD
PMID:11779144
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
G
Pparg
peroxisome proliferator-activated receptor gamma
affects binding multiple interactions increases activity
ISO
fenofibric acid binds to PPARG protein fenofibric acid results in increased activity of [PPARG protein alternative form binds to RXRA protein] fenofibric acid results in increased activity of PPARG protein
CTD
PMID:11779144 PMID:15273253
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Rxra
retinoid X receptor alpha
multiple interactions
ISO
fenofibric acid results in increased activity of [PPARA protein binds to RXRA protein]; fenofibric acid results in increased activity of [PPARD protein binds to RXRA protein]; fenofibric acid results in increased activity of [PPARG protein alternative form binds to RXRA protein]
CTD
PMID:11779144
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
G
Serpine1
serpin family E member 1
multiple interactions decreases expression decreases secretion
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of SERPINE1 mRNA fenofibric acid results in decreased expression of SERPINE1 mRNA fenofibric acid results in decreased secretion of SERPINE1 protein
CTD
PMID:10364093 PMID:16197558
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
G
Slc16a1
solute carrier family 16 member 1
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of SLC16A1 mRNA
CTD
PMID:16197558
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
G
Slc25a20
solute carrier family 25 member 20
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of SLC25A20 mRNA
CTD
PMID:16197558
NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
G
Spp1
secreted phosphoprotein 1
multiple interactions
ISO
fenofibric acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]; PPARA protein affects the reaction [fenofibric acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SPP1 mRNA]]
CTD
PMID:17360982
NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
fenofibric acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; fenofibric acid inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; fenofibric acid inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; fenofibric acid inhibits the reaction [TGFB1 protein results in increased expression of TGFB1 mRNA]
CTD
PMID:18513333
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tmem53
transmembrane protein 53
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of TMEM53 mRNA
CTD
PMID:16197558
NCBI chr 5:130,721,780...130,737,692
Ensembl chr 5:130,721,659...130,737,692
G
Txnip
thioredoxin interacting protein
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of TXNIP mRNA
CTD
PMID:16197558
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
ISO
fenofibric acid results in increased expression of UGT1A1 mRNA
CTD
PMID:15771232
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Vnn1
vanin 1
multiple interactions
ISO
[fenofibric acid binds to PPARA protein] which results in increased expression of VNN1 mRNA
CTD
PMID:16197558
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
G
Clcn1
chloride voltage-gated channel 1
decreases activity multiple interactions affects activity
ISO EXP
2-(4-chlorophenoxy)propionic acid analog results in decreased activity of CLCN1 protein 2-(4-chlorophenoxy)propionic acid affects the reaction [Chlorides binds to CLCN1 protein] 2-(4-chlorophenoxy)propionic acid affects the activity of CLCN1 protein 2-(4-chlorophenoxy)propionic acid affects the activity of CLCN1 protein; 2-(4-chlorophenoxy)propionic acid affects the activity of CLCN1 protein mutant form; 2-(4-chlorophenoxy)propionic acid analog affects the activity of CLCN1 protein
CTD
PMID:10217531 PMID:10953042 PMID:11408615 PMID:12130677 PMID:12890704
NCBI chr 4:71,171,949...71,201,483
Ensembl chr 4:71,172,547...71,199,984
G
Clcnka
chloride voltage-gated channel Ka
decreases activity
EXP
2-(4-chlorophenoxy)propionic acid analog results in decreased activity of CLCNKA protein
CTD
PMID:12130677 PMID:14694153
NCBI chr 5:153,691,208...153,706,295
Ensembl chr 5:153,691,209...153,706,148
G
Ache
acetylcholinesterase
multiple interactions
EXP
[dichlorfop-methyl co-treated with difenoconazole] results in decreased activity of ACHE protein
CTD
PMID:25419412
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Alb
albumin
affects binding
ISO
dichlorfop-methyl binds to ALB protein
CTD
PMID:32278049
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
G
Cat
catalase
increases activity
EXP
dichlorfop-methyl results in increased activity of CAT protein
CTD
PMID:11275354
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
dichlorfop-methyl binds to and results in increased activity of PPARA protein
CTD
PMID:17084873
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
G
Gsta3
glutathione S-transferase alpha 3
increases expression
EXP
fenoprop results in increased expression of GSTA3 protein
CTD
PMID:8914623
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
G
Gstm2
glutathione S-transferase mu 2
decreases expression
EXP
fenoprop results in decreased expression of GSTM2 protein
CTD
PMID:8914623
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
Esr1
estrogen receptor 1
increases activity
ISO
fluazifop-butyl results in increased activity of ESR1 protein
CTD
PMID:15064155
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
fluazifop-butyl results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Crat
carnitine O-acetyltransferase
increases activity
ISO
mecoprop results in increased activity of CRAT protein
CTD
PMID:1755024
NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
G
Ephx2
epoxide hydrolase 2
increases activity
ISO
mecoprop results in increased activity of EPHX2 protein
CTD
PMID:1755024
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
G
Ifng
interferon gamma
decreases expression
ISO
mecoprop results in decreased expression of IFNG protein
CTD
PMID:10883730
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Tnf
tumor necrosis factor
decreases expression
ISO
mecoprop results in decreased expression of TNF protein
CTD
PMID:10883730
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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