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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lysophosphatidylcholine
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Accession:CHEBI:60479 term browser browse the term
Definition:An acylglycerophosphocholine resulting from partial hydrolysis of a phosphatidylcholine, which removes one of the fatty acyl groups. The structure is depicted in the image where R1 = acyl, R2 = H or where R1 = H, R2 = acyl.
Synonyms:related_synonym: Formula=C9H19NO7PR;   SMILES=[C@](CO*)(O*)([H])COP(OCC[N+](C)(C)C)(=O)[O-];   lysophosphatidylcholines;   monoacylglycero-3-phosphocholine
 alt_id: MESH:D008244
 xref_mesh: MESH:D008244

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lysophosphatidylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arntl aryl hydrocarbon receptor nuclear translocator-like affects abundance ISO ARNTL gene mutant form affects the abundance of Lysophosphatidylcholines CTD PMID:27056296 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465 		JBrowse link
G Cav1 caveolin 1 multiple interactions
increases expression		 ISO alpha-Tocopherol inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]; Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]; Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 protein]
Lysophosphatidylcholines results in increased expression of CAV1 mRNA; Lysophosphatidylcholines results in increased expression of CAV1 protein		 CTD PMID:27257344 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO [[Capsaicin results in increased chemical synthesis of Lysophosphatidylcholines] which results in increased secretion of Lysophosphatidylcholines] promotes the reaction [ENPP2 results in increased chemical synthesis of lysophosphatidic acid]; [ENPP2 protein co-treated with Lysophosphatidylcholines] results in increased chemical synthesis of lysophosphatidic acid CTD PMID:19014389 NCBI chr 7:94,479,931...94,563,086
Ensembl chr 7:94,480,396...94,563,001 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 increases hydrolysis ISO ENPP7 protein results in increased hydrolysis of Lysophosphatidylcholines CTD PMID:12885774 NCBI chr10:108,095,131...108,099,483
Ensembl chr10:108,095,131...108,099,483 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases expression ISO Lysophosphatidylcholines results in increased expression of FSCN1 mRNA CTD PMID:22102721 NCBI chr12:13,655,459...13,668,595
Ensembl chr12:13,656,554...13,668,515 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases ubiquitination
multiple interactions		 EXP Lysophosphatidylcholines results in increased ubiquitination of GJA1 protein
Lysophosphatidylcholines affects the localization of and results in increased phosphorylation of GJA1 protein; PRKCE affects the reaction [Lysophosphatidylcholines results in increased phosphorylation of GJA1 protein]		 CTD PMID:23973256 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Lysophosphatidylcholines results in increased expression of HMOX1 mRNA CTD PMID:9808084 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of ICAM1 mRNA
quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]; Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]		 CTD PMID:27257344 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO Lysophosphatidylcholines results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838 		JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO Lysophosphatidylcholines results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO Lysophosphatidylcholines results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK1 protein] CTD PMID:20564508 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK3 protein]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK3 protein] CTD PMID:20564508 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A increases transport ISO MFSD2A results in increased transport of Lysophosphatidylcholines CTD PMID:26005865 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased expression of NOS2 mRNA] CTD PMID:20564508 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in decreased expression of NOS3 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in decreased expression of NOS3 mRNA] CTD PMID:20564508 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Lysophosphatidylcholines CTD PMID:29515023 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428 		JBrowse link
G Pah phenylalanine hydroxylase multiple interactions ISO Lysophosphatidylcholines results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr 7:28,066,639...28,129,772
Ensembl chr 7:28,066,635...28,129,769 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP PRKCE affects the reaction [Lysophosphatidylcholines results in increased phosphorylation of GJA1 protein] CTD PMID:23973256 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
multiple interactions		 EXP Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]		 CTD PMID:20564508 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased expression of PTGS2 mRNA] CTD PMID:20564508 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Lysophosphatidylcholines CTD PMID:30258081 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions ISO Lysophosphatidylcholines promotes the reaction [TRPC5 protein results in increased transport of Calcium]; resveratrol inhibits the reaction [Lysophosphatidylcholines promotes the reaction [TRPC5 protein results in increased transport of Calcium]] CTD PMID:21127073 NCBI chr  X:115,624,670...115,908,248
Ensembl chr  X:115,627,653...115,908,693 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Lysophosphatidylcholines results in increased expression of VCAM1 mRNA CTD PMID:27257344 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
1-O-oleoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:29515023 NCBI chr13:53,750,470...53,870,288
Ensembl chr13:53,750,473...53,870,428 		JBrowse link
G Smad3 SMAD family member 3 decreases abundance ISO SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
1-stearoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr18:70,903,528...70,924,434
Ensembl chr18:70,901,710...70,924,708 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      biological role 19825
        osmolyte 2046
          glycerol 1772
            glycerolipid 263
              glycerophospholipid 200
                glycerophosphocholine 116
                  lysophosphatidylcholine 27
                    1-O-acyl-sn-glycero-3-phosphocholine(1+) + 0
                    1-acylglycerophosphocholine(1+) + 0
                    1-lysophosphatidylcholine + 0
                    2-acylglycerophosphocholine + 0
                    2-lysophosphatidylcholine + 4
                    LysoPC(18:3(6Z,9Z,12Z)) 0
                    LysoPC(18:3(9Z,12Z,15Z)) 0
                    LysoPC(18:4(6Z,9Z,12Z,15Z)) 0
                    LysoPC(20:5(5Z,8Z,11Z,14Z,17Z)) 0
                    LysoPC(22:1(13Z)) 0
                    LysoPC(22:2(13Z,16Z)) 0
                    LysoPC(24:1(15Z)) 0
                    acyl-sn-glycero-3-phosphocholine + 4
                    lysophosphatidylcholine 12:0 0
                    lysophosphatidylcholine 14:0 + 0
                    lysophosphatidylcholine 14:1 + 0
                    lysophosphatidylcholine 14:2 0
                    lysophosphatidylcholine 15:0 + 0
                    lysophosphatidylcholine 15:1 0
                    lysophosphatidylcholine 15:2 0
                    lysophosphatidylcholine 16:0 + 0
                    lysophosphatidylcholine 16:1 + 0
                    lysophosphatidylcholine 16:2 0
                    lysophosphatidylcholine 17:0 + 0
                    lysophosphatidylcholine 17:1 + 0
                    lysophosphatidylcholine 18:0 + 2
                    lysophosphatidylcholine 18:1 + 2
                    lysophosphatidylcholine 18:2 + 0
                    lysophosphatidylcholine 18:3 + 0
                    lysophosphatidylcholine 18:4 + 0
                    lysophosphatidylcholine 19:0 + 0
                    lysophosphatidylcholine 20:0 + 0
                    lysophosphatidylcholine 20:1 + 0
                    lysophosphatidylcholine 20:2 + 0
                    lysophosphatidylcholine 20:3 + 0
                    lysophosphatidylcholine 20:4 + 0
                    lysophosphatidylcholine 20:5 + 0
                    lysophosphatidylcholine 22:0 0
                    lysophosphatidylcholine 22:1 0
                    lysophosphatidylcholine 22:2 0
                    lysophosphatidylcholine 22:4 + 0
                    lysophosphatidylcholine 22:5 + 0
                    lysophosphatidylcholine 22:6 + 0
                    lysophosphatidylcholine 24:0 + 0
                    lysophosphatidylcholine 24:1 0
                    lysophosphatidylcholine 26:0 0
                    lysophosphatidylcholine 26:1 0
                    lysophosphatidylcholine 28:0 0
                    lysophosphatidylcholine 28:1 0
                    lysophosphatidylcholine 6:0 + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      chalcogen 19454
                        oxygen atom 19415
                          oxygen molecular entity 19415
                            hydroxides 19139
                              oxoacid 18273
                                pnictogen oxoacid 10308
                                  phosphorus oxoacid 9228
                                    phosphoric acids 7945
                                      phosphoric acid 7945
                                        phosphoric acid derivative 7624
                                          phosphate 7624
                                            organic phosphate 7623
                                              phospholipid 294
                                                glycerophospholipid 200
                                                  glycerophosphocholine 116
                                                    lysophosphatidylcholine 27
                                                      1-O-acyl-sn-glycero-3-phosphocholine(1+) + 0
                                                      1-acylglycerophosphocholine(1+) + 0
                                                      1-lysophosphatidylcholine + 0
                                                      2-acylglycerophosphocholine + 0
                                                      2-lysophosphatidylcholine + 4
                                                      LysoPC(18:3(6Z,9Z,12Z)) 0
                                                      LysoPC(18:3(9Z,12Z,15Z)) 0
                                                      LysoPC(18:4(6Z,9Z,12Z,15Z)) 0
                                                      LysoPC(20:5(5Z,8Z,11Z,14Z,17Z)) 0
                                                      LysoPC(22:1(13Z)) 0
                                                      LysoPC(22:2(13Z,16Z)) 0
                                                      LysoPC(24:1(15Z)) 0
                                                      acyl-sn-glycero-3-phosphocholine + 4
                                                      lysophosphatidylcholine 12:0 0
                                                      lysophosphatidylcholine 14:0 + 0
                                                      lysophosphatidylcholine 14:1 + 0
                                                      lysophosphatidylcholine 14:2 0
                                                      lysophosphatidylcholine 15:0 + 0
                                                      lysophosphatidylcholine 15:1 0
                                                      lysophosphatidylcholine 15:2 0
                                                      lysophosphatidylcholine 16:0 + 0
                                                      lysophosphatidylcholine 16:1 + 0
                                                      lysophosphatidylcholine 16:2 0
                                                      lysophosphatidylcholine 17:0 + 0
                                                      lysophosphatidylcholine 17:1 + 0
                                                      lysophosphatidylcholine 18:0 + 2
                                                      lysophosphatidylcholine 18:1 + 2
                                                      lysophosphatidylcholine 18:2 + 0
                                                      lysophosphatidylcholine 18:3 + 0
                                                      lysophosphatidylcholine 18:4 + 0
                                                      lysophosphatidylcholine 19:0 + 0
                                                      lysophosphatidylcholine 20:0 + 0
                                                      lysophosphatidylcholine 20:1 + 0
                                                      lysophosphatidylcholine 20:2 + 0
                                                      lysophosphatidylcholine 20:3 + 0
                                                      lysophosphatidylcholine 20:4 + 0
                                                      lysophosphatidylcholine 20:5 + 0
                                                      lysophosphatidylcholine 22:0 0
                                                      lysophosphatidylcholine 22:1 0
                                                      lysophosphatidylcholine 22:2 0
                                                      lysophosphatidylcholine 22:4 + 0
                                                      lysophosphatidylcholine 22:5 + 0
                                                      lysophosphatidylcholine 22:6 + 0
                                                      lysophosphatidylcholine 24:0 + 0
                                                      lysophosphatidylcholine 24:1 0
                                                      lysophosphatidylcholine 26:0 0
                                                      lysophosphatidylcholine 26:1 0
                                                      lysophosphatidylcholine 28:0 0
                                                      lysophosphatidylcholine 28:1 0
                                                      lysophosphatidylcholine 6:0 + 0
paths to the root