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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isonicotinic acid
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Accession:CHEBI:6032 term browser browse the term
Definition:A pyridinemonocarboxylic acid in which the carboxy group is at position 4 of the pyridine ring.
Synonyms:related_synonym: 4-carboxypyridine;   4-pyridinecarboxylic acid;   Formula=C6H5NO2;   InChI=1S/C6H5NO2/c8-6(9)5-1-3-7-4-2-5/h1-4H,(H,8,9);   InChIKey=TWBYWOBDOCUKOW-UHFFFAOYSA-N;   SMILES=OC(=O)c1ccncc1;   gamma-picolinic acid;   gamma-pyridinecarboxylic acid;   p-pyridinecarboxylic acid;   pyridine-4-carboxylic acid
 xref: Beilstein:109599;   CAS:55-22-1;   Gmelin:68876;   HMDB:HMDB0060665;   KEGG:C07446;   PMID:13115353;   PMID:22537922;   PMID:23832340;   PMID:23929452;   Reaxys:109599;   Wikipedia:Isonicotinic_Acid
 cyclic_relationship: is_conjugate_acid_of CHEBI:38186


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4-pyridoxic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pyridoxic Acid CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546 		JBrowse link
isoniazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Isoniazid results in increased expression of A2M mRNA CTD PMID:12883083 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases expression		 EXP
ISO		 [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCB11 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCB11 mRNA]
Isoniazid results in decreased expression of ABCB11 protein
[Rifampin co-treated with Isoniazid] results in decreased expression of ABCB11 protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCB11 protein		 CTD PMID:25331106 PMID:25886055 PMID:32673658 PMID:35835356 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP Isoniazid results in increased expression of ABCC1 mRNA CTD PMID:11752103 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
decreases expression		 EXP [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of ABCC2 protein; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCC2 mRNA
Isoniazid results in decreased expression of ABCC2 mRNA		 CTD PMID:25331106 PMID:32673658 PMID:35835356 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
decreases expression		 EXP [Lipopolysaccharides co-treated with Isoniazid] results in increased expression of ABCC3 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of ABCC3 mRNA] CTD PMID:25331106 PMID:32673658 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases expression EXP Isoniazid results in decreased expression of ABCC4 mRNA CTD PMID:32673658 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283 		JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 decreases expression EXP Isoniazid results in decreased expression of ABCC6 mRNA CTD PMID:16260000 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Isoniazid results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of ACSL4 protein CTD PMID:36878459 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Afp alpha-fetoprotein decreases expression ISO Isoniazid results in decreased expression of AFP mRNA CTD PMID:30008028 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Agpat3 1-acylglycerol-3-phosphate O-acyltransferase 3 increases expression
multiple interactions		 EXP Isoniazid results in increased expression of AGPAT3 mRNA
[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in increased expression of AGPAT3 mRNA]		 CTD PMID:28619387 NCBI chr20:10,330,960...10,415,358
Ensembl chr20:10,384,507...10,415,358 		JBrowse link
G Akr1b10 aldo-keto reductase family 1 member B10 increases expression ISO Isoniazid results in increased expression of AKR1B10 mRNA CTD PMID:28444390 NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852 		JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO Isoniazid results in increased expression of ALAS1 protein CTD PMID:27438535 PMID:30517741 NCBI chr 8:106,876,514...106,889,917
Ensembl chr 8:106,876,514...106,889,917 		JBrowse link
G Alb albumin affects binding ISO Isoniazid binds to ALB protein CTD PMID:25489718 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases activity
multiple interactions		 ISO Isoniazid results in increased activity of ALPL protein
[Rifampin co-treated with Isoniazid] results in increased activity of ALPL protein		 CTD PMID:25886055 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Apoa4 apolipoprotein A4 affects response to substance ISO APOA4 affects the susceptibility to Isoniazid CTD PMID:24848797 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apoa5 apolipoprotein A5 multiple interactions
decreases expression		 EXP [Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of APOA5 mRNA]
Isoniazid results in decreased expression of APOA5 mRNA		 CTD PMID:28619387 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816 		JBrowse link
G App amyloid beta precursor protein increases expression ISO Isoniazid results in increased expression of APP mRNA CTD PMID:30008028 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Asl argininosuccinate lyase increases activity
multiple interactions		 EXP Isoniazid results in increased activity of ASL protein
[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein; Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased activity of ASL protein]		 CTD PMID:28619387 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662 		JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 increases expression ISO Isoniazid results in increased expression of ATP1B1 mRNA CTD PMID:30008028 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects expression ISO Isoniazid affects the expression of ATP5F1B mRNA CTD PMID:24848797 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273 		JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 affects expression ISO Isoniazid affects the expression of ATP5MC1 mRNA CTD PMID:24848797 NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124 		JBrowse link
G Atp5mc3 ATP synthase membrane subunit c locus 3 affects expression ISO Isoniazid affects the expression of ATP5MC3 mRNA CTD PMID:24848797 NCBI chr 3:58,810,535...58,813,185
Ensembl chr 3:58,810,535...58,814,279 		JBrowse link
G Atp5pb ATP synthase peripheral stalk-membrane subunit b affects expression ISO Isoniazid affects the expression of ATP5PB mRNA CTD PMID:24848797 NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418 		JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 affects expression ISO Isoniazid affects the expression of ATP5PF mRNA CTD PMID:24848797 NCBI chr11:23,881,594...23,889,581
Ensembl chr11:23,881,592...23,889,119 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
affects expression		 ISO
EXP		 [Isoniazid co-treated with Rifampin] results in increased expression of BAX protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased expression of BAX protein]
Isoniazid results in increased expression of BAX protein
Quercetin inhibits the reaction [Isoniazid results in increased expression of BAX protein]
chrysin inhibits the reaction [Isoniazid results in increased expression of BAX protein]
Isoniazid results in increased expression of BAX mRNA
Isoniazid affects the expression of BAX protein		 CTD PMID:20433247 PMID:21419764 PMID:31332904 PMID:33121995 PMID:33771660 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 increases expression ISO Isoniazid results in increased expression of BBOX1 mRNA CTD PMID:30008028 NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in decreased expression of BCL2 protein]
Quercetin inhibits the reaction [Isoniazid results in decreased expression of BCL2 protein]
Isoniazid results in decreased expression of BCL2 mRNA		 CTD PMID:20433247 PMID:21419764 PMID:31332904 PMID:33771660 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage		 ISO
EXP		 [Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]; Ursodeoxycholic Acid inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein]
Isoniazid results in increased activity of CASP3 protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CASP3
Isoniazid results in increased expression of CASP3 mRNA
Isoniazid results in increased cleavage of CASP3 protein
acadesine promotes the reaction [Isoniazid results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [Isoniazid results in increased cleavage of CASP3 protein]		 CTD PMID:20433247 PMID:21419764 PMID:23764483 PMID:28556920 PMID:31332904 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
multiple interactions		 ISO Isoniazid results in increased cleavage of CASP9 protein
Isoniazid results in increased activity of CASP9 protein
Quercetin inhibits the reaction [Isoniazid results in increased cleavage of CASP9 protein]		 CTD PMID:20433247 PMID:31332904 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Casr calcium-sensing receptor affects expression EXP Isoniazid affects the expression of CASR mRNA CTD PMID:20623750 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 EXP
ISO		 Isoniazid results in decreased activity of CAT protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CAT protein; chrysin inhibits the reaction [Isoniazid results in decreased activity of CAT protein]		 CTD PMID:20433247 PMID:33121995 PMID:33771660 PMID:36878459 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression EXP Isoniazid results in decreased expression of CCR2 mRNA CTD PMID:20623750 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO Isoniazid results in decreased expression of CEBPA mRNA; Isoniazid results in decreased expression of CEBPA protein CTD PMID:24128855 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Isoniazid results in decreased expression of CEBPB protein CTD PMID:24128855 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO Isoniazid results in decreased expression of CEBPD mRNA; Isoniazid results in decreased expression of CEBPD protein CTD PMID:24128855 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829 		JBrowse link
G Chpt1 choline phosphotransferase 1 affects response to substance ISO CHPT1 affects the susceptibility to Isoniazid CTD PMID:24848797 NCBI chr 7:22,866,455...22,915,111
Ensembl chr 7:22,863,027...22,915,103 		JBrowse link
G Cldn2 claudin 2 increases expression ISO Isoniazid results in increased expression of CLDN2 mRNA CTD PMID:30008028 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838 		JBrowse link
G Cox11 cytochrome c oxidase copper chaperone COX11 affects expression ISO Isoniazid affects the expression of COX11 mRNA CTD PMID:24848797 NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322 		JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 affects expression ISO Isoniazid affects the expression of COX17 mRNA CTD PMID:24848797 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cox5b cytochrome c oxidase subunit 5B affects expression ISO Isoniazid affects the expression of COX5B mRNA CTD PMID:24848797 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052 		JBrowse link
G Cox6a1 cytochrome c oxidase subunit 6A1 affects expression ISO Isoniazid affects the expression of COX6A1 mRNA CTD PMID:24848797 NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041 		JBrowse link
G Cox6b1 cytochrome c oxidase subunit 6B1 affects expression ISO Isoniazid affects the expression of COX6B1 mRNA CTD PMID:24848797 NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001
Ensembl chr 2:85,875,109...85,884,001 		JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 affects expression ISO Isoniazid affects the expression of COX7A2 mRNA CTD PMID:24848797 NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633
Ensembl chr 8:51,301,168...51,301,633 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A affects expression ISO Isoniazid affects the expression of CPT1A mRNA CTD PMID:24848797 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 increases secretion ISO Isoniazid results in increased secretion of CXCL10 protein CTD PMID:28444390 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions
decreases expression		 EXP [Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of CYB5A mRNA]
Isoniazid results in decreased expression of CYB5A mRNA		 CTD PMID:28619387 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression EXP Isoniazid results in increased expression of CYP27A1 mRNA CTD PMID:32673658 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity
multiple interactions		 ISO Isoniazid results in decreased activity of CYP2C8 protein
torsemide inhibits the reaction [Isoniazid results in decreased activity of CYP2C8 protein]		 CTD PMID:15304522
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects response to substance
increases response to substance
multiple interactions
increases activity
increases expression
increases metabolic processing		 ISO
EXP		 CYP2E1 gene polymorphism affects the susceptibility to Isoniazid; CYP2E1 gene SNP affects the susceptibility to Isoniazid
CYP2E1 protein results in increased susceptibility to Isoniazid
GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid]
Isoniazid results in increased activity of CYP2E1 protein
Berberine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 mRNA]
Isoniazid results in increased expression of CYP2E1; Isoniazid results in increased expression of CYP2E1 mRNA; Isoniazid results in increased expression of CYP2E1 protein
2-(allylthio)pyrazine inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein; [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA; [Isoniazid results in increased activity of CYP2E1 protein] which results in increased metabolism of 4-dichlorobenzene; [Isoniazid results in increased expression of CYP2E1] which results in increased metabolism of Acetaminophen; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Isoniazid inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Isoniazid results in increased expression of and results in increased activity of CYP2E1 protein; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA]; Rifampin inhibits the reaction [Isoniazid results in increased expression of CYP2E1 protein]; Thiram inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]; Tiopronin inhibits the reaction [Isoniazid results in increased activity of CYP2E1 protein]
CYP2E1 protein results in increased metabolism of Isoniazid		 CTD PMID:3113478 PMID:7710944 PMID:8074729 PMID:9051121 PMID:9065729 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
increases response to substance		 EXP
ISO		 [Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]; [SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid; Methionine inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA]
Isoniazid results in decreased activity of CYP3A4 protein
CYP3A4 protein results in increased susceptibility to Isoniazid		 CTD PMID:15005856 PMID:15304522 PMID:19501153 PMID:21540358 PMID:27919644 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
increases activity
multiple interactions		 EXP Isoniazid results in increased expression of CYP3A23-3A1 mRNA
Isoniazid results in increased activity of CYP3A23-3A1 protein
diphenyleneiodonium inhibits the reaction [Isoniazid results in increased activity of CYP3A23-3A1 protein]		 CTD PMID:12883083 PMID:26880746 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
increases expression		 EXP
ISO		 [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of CYP7A1 protein; [Lipopolysaccharides co-treated with Isoniazid] results in increased expression of CYP7A1 mRNA; obeticholic acid inhibits the reaction [Isoniazid results in increased expression of CYP7A1 mRNA]
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of CYP7A1 protein; [Isoniazid co-treated with Vitamin B 6] results in increased expression of CYP7A1 mRNA		 CTD PMID:25331106 PMID:32673658 PMID:35835356 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
decreases expression		 EXP
ISO		 Isoniazid results in increased expression of DDIT3 mRNA
Isoniazid results in decreased expression of DDIT3 mRNA		 CTD PMID:12883083 PMID:30008028 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Isoniazid results in increased expression of DEPP1 mRNA CTD PMID:17175557 NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542 		JBrowse link
G Epx eosinophil peroxidase increases oxidation
multiple interactions		 ISO EPX protein results in increased oxidation of Isoniazid
[EPX protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of isonicotinyl-NAD		 CTD PMID:30922765 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952 		JBrowse link
G Fech ferrochelatase decreases expression ISO Isoniazid results in decreased expression of FECH protein CTD PMID:27438535 PMID:30517741 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity ISO Isoniazid results in decreased activity of G6PD protein CTD PMID:20433247 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression EXP Isoniazid results in decreased expression of GADD45A mRNA CTD PMID:20623750 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression EXP Isoniazid results in increased expression of GAPDH mRNA CTD PMID:12883083 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
decreases expression		 ISO
EXP		 Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GCLC mRNA]
Isoniazid results in increased expression of GCLC mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of GCLC mRNA]
Isoniazid results in decreased expression of GCLC mRNA		 CTD PMID:24128855 PMID:33121995 PMID:33771660 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression
increases expression
multiple interactions		 ISO
EXP		 Isoniazid results in decreased expression of GCLM mRNA
Isoniazid results in increased expression of GCLM mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of GCLM mRNA]		 CTD PMID:30008028 PMID:33121995 PMID:33771660 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 EXP chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP mRNA]; chrysin inhibits the reaction [Isoniazid results in increased expression of GFAP protein]
Isoniazid results in increased expression of GFAP mRNA; Isoniazid results in increased expression of GFAP protein		 CTD PMID:33121995 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GGT1 protein CTD PMID:25331106 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions
increases activity		 ISO [Rifampin co-treated with Isoniazid] results in increased activity of GOT1 protein
Isoniazid results in increased activity of GOT1 protein		 CTD PMID:25886055 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity
multiple interactions
increases expression		 EXP
ISO		 Isoniazid results in increased activity of GPT protein
[Rifampin co-treated with Isoniazid] results in increased activity of GPT protein
Quercetin inhibits the reaction [Isoniazid results in increased expression of GPT protein]
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPT protein; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein; [Lipopolysaccharides co-treated with Isoniazid] results in increased activity of GPT protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein]; Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]; Silybin inhibits the reaction [Isoniazid promotes the reaction [Zidovudine results in increased activity of GPT protein]]		 CTD PMID:25331106 PMID:25886055 PMID:28619387 PMID:31332904 PMID:35835356 More... NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein] CTD PMID:36878459 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP Isoniazid results in increased expression of GSTA2 mRNA CTD PMID:12883083 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions
decreases response to substance		 ISO GSTM1 protein inhibits the reaction [CYP2E1 protein results in increased susceptibility to Isoniazid]
GSTM1 protein results in decreased susceptibility to Isoniazid		 CTD PMID:28762043 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Isoniazid results in decreased expression of GSTP1 mRNA CTD PMID:20623750 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Gstt1 glutathione S-transferase theta 1 multiple interactions ISO GSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]; GSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide] CTD PMID:18397238 PMID:20485159 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 affects expression EXP Isoniazid affects the expression of HAVCR1 mRNA CTD PMID:20623750 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hgf hepatocyte growth factor multiple interactions ISO HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased abundance of Reactive Oxygen Species]; HGF protein inhibits the reaction [[Isoniazid co-treated with Rifampin] results in increased activity of CASP3 protein] CTD PMID:23764483 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of HIF1A protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of GPX4 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein]; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of GPT protein] CTD PMID:36878459 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of HMOX1 mRNA]
Isoniazid results in increased expression of HMOX1 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of HMOX1 mRNA]
Isoniazid results in decreased expression of HMOX1 mRNA		 CTD PMID:24128855 PMID:33121995 PMID:33771660 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hmox2 heme oxygenase 2 increases expression EXP Isoniazid results in increased expression of HMOX2 mRNA CTD PMID:12883083 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 increases expression EXP Isoniazid results in increased expression of HPRT1 mRNA CTD PMID:12883083 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154 		JBrowse link
G Ifng interferon gamma increases secretion ISO Isoniazid results in increased secretion of IFNG protein CTD PMID:28444390 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il10 interleukin 10 increases secretion ISO Isoniazid results in increased secretion of IL10 protein CTD PMID:28444390 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12a interleukin 12A increases secretion ISO Isoniazid results in increased secretion of IL12A protein CTD PMID:28444390 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B increases secretion ISO Isoniazid results in increased secretion of IL12B protein CTD PMID:28444390 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il17a interleukin 17A increases secretion ISO Isoniazid results in increased secretion of IL17A protein CTD PMID:28444390 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il1a interleukin 1 alpha increases secretion
increases expression		 ISO Isoniazid results in increased secretion of IL1A protein
Isoniazid results in increased expression of IL1A mRNA		 CTD PMID:28444390 PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases secretion
multiple interactions
increases expression		 ISO
EXP		 Isoniazid results in increased secretion of IL1B protein
chrysin inhibits the reaction [Isoniazid results in increased expression of IL1B mRNA]		 CTD PMID:28444390 PMID:32816093 PMID:33121995 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Isoniazid co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA CTD PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il24 interleukin 24 increases expression ISO Isoniazid results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487 		JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
increases secretion		 ISO
EXP		 Isoniazid results in increased expression of IL6 protein
Isoniazid results in increased expression of IL6 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of IL6 mRNA]
Isoniazid results in increased secretion of IL6 protein		 CTD PMID:19575532 PMID:28444390 PMID:33121995 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Isoniazid results in increased expression of INHBE mRNA CTD PMID:17175557 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172 		JBrowse link
G Izumo1r IZUMO1 receptor, JUNO decreases expression ISO Isoniazid results in decreased expression of IZUMO1R protein CTD PMID:33771660 NCBI chr 8:11,744,384...11,748,131
Ensembl chr 8:11,725,863...11,748,465 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression ISO Isoniazid results in decreased expression of KEAP1 mRNA CTD PMID:33771660 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 affects response to substance ISO LAMP1 affects the susceptibility to Isoniazid CTD PMID:24848797 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Isoniazid results in increased expression of LCN2 mRNA CTD PMID:20623750 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095 		JBrowse link
G Map2 microtubule-associated protein 2 affects expression ISO Isoniazid affects the expression of MAP2 mRNA CTD PMID:22131109 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO Isoniazid results in decreased phosphorylation of MAPK1 protein
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK1 protein]]; Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:31332904 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK3 protein]]; Quercetin inhibits the reaction [Isoniazid results in decreased phosphorylation of MAPK3 protein] CTD PMID:31332904 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 increases expression ISO Isoniazid results in increased expression of MGST1 mRNA CTD PMID:33771660 NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892 		JBrowse link
G Mir106b microRNA 106b decreases expression EXP Isoniazide decreased expression of miR106b miRNA in the liver RGD PMID:29554950 RGD:15042854 NCBI chr12:17,043,344...17,043,425
Ensembl chr12:17,043,344...17,043,425 		JBrowse link
G Mpo myeloperoxidase multiple interactions
increases oxidation		 ISO [[MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of Free Radicals] which results in increased chemical synthesis of isonicotinyl-NAD; [MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of Free Radicals; [MPO protein results in increased oxidation of Isoniazid] which results in increased chemical synthesis of isonicotinyl-NAD CTD PMID:26867495 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III increases expression EXP Isoniazid results in increased expression of COX3 mRNA CTD PMID:12883083 NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382 		JBrowse link
G Muc1 mucin 1, cell surface associated increases expression ISO Isoniazid results in increased expression of MUC1 mRNA CTD PMID:30008028 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Nat2 N-acetyltransferase 2 increases acetylation
affects acetylation
multiple interactions
decreases expression
decreases acetylation
increases metabolic processing
affects metabolic processing
affects response to substance		 ISO
EXP		 NAT2 protein polymorphism results in increased acetylation of Isoniazid; NAT2 protein results in increased acetylation of Isoniazid
NAT2 protein polymorphism affects the acetylation of Isoniazid
[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of NAT2 mRNA]
Isoniazid results in decreased expression of NAT2 mRNA
[NAT2 gene polymorphism results in decreased acetylation of Isoniazid] which results in decreased abundance of acetylisoniazid; [NAT2 gene polymorphism results in decreased metabolism of Isoniazid] which results in increased abundance of hydrazine
NAT2 protein results in increased metabolism of Isoniazid
NAT2 protein affects the metabolism of Isoniazid; NAT2 protein polymorphism affects the metabolism of Isoniazid
NAT2 gene polymorphism affects the susceptibility to Isoniazid; NAT2 gene SNP affects the susceptibility to Isoniazid		 CTD PMID:11379777 PMID:11915035 PMID:15546075 PMID:15565348 PMID:15618686 More... NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Ncr3lg1 natural killer cell cytotoxicity receptor 3 ligand 1 increases expression ISO Isoniazid results in increased expression of NCR3LG1 mRNA; Isoniazid results in increased expression of NCR3LG1 protein CTD PMID:32060585 NCBI chr 1:96,565,664...96,581,825
Ensembl chr 1:96,574,455...96,580,466 		JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 affects expression ISO Isoniazid affects the expression of NDUFA1 mRNA CTD PMID:24848797 NCBI chr  X:116,424,223...116,427,875
Ensembl chr  X:116,424,223...116,428,633 		JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 affects expression ISO Isoniazid affects the expression of NDUFA10 mRNA CTD PMID:24848797 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560 		JBrowse link
G Ndufa12 NADH:ubiquinone oxidoreductase subunit A12 affects expression ISO Isoniazid affects the expression of NDUFA12 mRNA CTD PMID:24848797 NCBI chr 7:28,771,330...28,798,316
Ensembl chr 7:28,771,330...28,798,315 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 affects expression ISO Isoniazid affects the expression of NDUFA13 mRNA CTD PMID:24848797 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726 		JBrowse link
G Ndufa4 Ndufa4, mitochondrial complex associated affects expression ISO Isoniazid affects the expression of NDUFA4 mRNA CTD PMID:24848797 NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920 		JBrowse link
G Ndufa5 NADH:ubiquinone oxidoreductase subunit A5 affects expression ISO Isoniazid affects the expression of NDUFA5 mRNA CTD PMID:24848797 NCBI chr 4:52,997,327...53,005,685
Ensembl chr 4:52,995,546...53,005,598 		JBrowse link
G Ndufa8 NADH:ubiquinone oxidoreductase subunit A8 affects expression ISO Isoniazid affects the expression of NDUFA8 mRNA CTD PMID:24848797 NCBI chr 3:19,386,062...19,402,090
Ensembl chr 3:19,386,065...19,402,071 		JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 affects expression ISO Isoniazid affects the expression of NDUFA9 mRNA CTD PMID:24848797 NCBI chr 4:159,659,242...159,688,034
Ensembl chr 4:159,659,242...159,688,018 		JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 affects expression ISO Isoniazid affects the expression of NDUFAB1 mRNA CTD PMID:24848797 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099 		JBrowse link
G Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 affects expression ISO Isoniazid affects the expression of NDUFB10 mRNA CTD PMID:24848797 NCBI chr10:13,749,273...13,751,434
Ensembl chr10:13,749,275...13,751,442 		JBrowse link
G Ndufb2 NADH:ubiquinone oxidoreductase subunit B2 affects expression ISO Isoniazid affects the expression of NDUFB2 mRNA CTD PMID:24848797 NCBI chr 4:68,367,526...68,374,609
Ensembl chr15:46,536,062...46,536,851
Ensembl chr 4:46,536,062...46,536,851 		JBrowse link
G Ndufb3 NADH:ubiquinone oxidoreductase subunit B3 affects expression ISO Isoniazid affects the expression of NDUFB3 mRNA CTD PMID:24848797 NCBI chr 9:60,129,240...60,139,452
Ensembl chr 9:60,129,154...60,139,446 		JBrowse link
G Ndufb5 NADH:ubiquinone oxidoreductase subunit B5 affects expression ISO Isoniazid affects the expression of NDUFB5 mRNA CTD PMID:24848797 NCBI chr 2:115,519,248...115,533,589
Ensembl chr 2:115,519,154...115,533,589 		JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 affects expression ISO Isoniazid affects the expression of NDUFB6 mRNA CTD PMID:24848797 NCBI chr 5:55,400,543...55,410,110
Ensembl chr 5:55,400,543...55,410,181 		JBrowse link
G Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 affects expression ISO Isoniazid affects the expression of NDUFB7 mRNA CTD PMID:24848797 NCBI chr19:24,568,241...24,572,579
Ensembl chr19:24,568,241...24,572,579 		JBrowse link
G Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 affects expression ISO Isoniazid affects the expression of NDUFS1 mRNA CTD PMID:24848797 NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893 		JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 affects expression ISO Isoniazid affects the expression of NDUFS2 mRNA CTD PMID:24848797 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420 		JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 affects expression ISO Isoniazid affects the expression of NDUFS3 mRNA CTD PMID:24848797 NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 affects expression ISO Isoniazid affects the expression of NDUFS4 mRNA CTD PMID:24848797 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846 		JBrowse link
G Ndufs8 NADH:ubiquinone oxidoreductase core subunit S8 affects expression ISO Isoniazid affects the expression of NDUFS8 mRNA CTD PMID:24848797 NCBI chr 1:201,140,585...201,144,573
Ensembl chr 1:201,140,585...201,144,511 		JBrowse link
G Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 affects expression ISO Isoniazid affects the expression of NDUFV1 mRNA CTD PMID:24848797 NCBI chr 1:201,300,365...201,305,461
Ensembl chr 1:201,299,985...201,305,466 		JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 affects expression ISO Isoniazid affects the expression of NDUFV2 mRNA CTD PMID:24848797 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity
increases expression
multiple interactions		 ISO
EXP		 Isoniazid results in increased activity of NFE2L2 protein
Isoniazid results in increased expression of NFE2L2 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of NFE2L2 mRNA]		 CTD PMID:30203046 PMID:33121995 PMID:33771660 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 EXP Isoniazid results in increased expression of NFKB1 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of NFKB1 mRNA]		 CTD PMID:33121995 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 Isoniazid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of NQO1 mRNA]
Isoniazid results in increased expression of NQO1 mRNA
chrysin inhibits the reaction [Isoniazid results in increased expression of NQO1 mRNA]
Isoniazid results in decreased expression of NQO1 mRNA		 CTD PMID:24128855 PMID:28444390 PMID:33121995 PMID:33771660 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression
multiple interactions		 EXP
ISO		 Isoniazid results in decreased expression of NR0B2 mRNA
[Isoniazid co-treated with Vitamin B 6] results in decreased expression of NR0B2 mRNA
obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR0B2 mRNA]		 CTD PMID:32673658 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions
decreases expression		 EXP
ISO		 [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of NR1H4 mRNA; [Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of NR1H4 protein; obeticholic acid inhibits the reaction [Isoniazid results in decreased expression of NR1H4 mRNA]
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4; [Isoniazid co-treated with Vitamin B 6] results in decreased expression of NR1H4 mRNA
isoniazide decreases expression of nr1h4 protein in rat liver		 CTD
RGD		 PMID:25331106 PMID:32673658 PMID:35835356 PMID:30068870 RGD:15042870 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Isoniazid results in increased activity of NR1I3 protein CTD PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Nrf1 nuclear respiratory factor 1 multiple interactions
decreases expression		 ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of NRF1 protein] CTD PMID:28556920 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Isoniazid results in increased expression of NUPR1 mRNA CTD PMID:17175557 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Ogdh oxoglutarate dehydrogenase affects expression ISO Isoniazid affects the expression of OGDH mRNA CTD PMID:24848797 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479 		JBrowse link
G Park7 Parkinsonism associated deglycase affects expression ISO Isoniazid affects the expression of PARK7 mRNA CTD PMID:24848797 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970 		JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Isoniazid results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044 		JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 increases expression ISO Isoniazid results in increased expression of PLOD2 mRNA CTD PMID:15997088 NCBI chr 8:93,084,548...93,167,255
Ensembl chr 8:93,084,513...93,167,255 		JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions
decreases expression		 EXP [Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA; silybin inhibits the reaction [[Zidovudine co-treated with Isoniazid] results in decreased expression of POR mRNA]
Isoniazid results in decreased expression of POR mRNA		 CTD PMID:28619387 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
multiple interactions		 ISO Isoniazid results in increased activity of PPARA protein
[Isoniazid co-treated with Rifampin] results in decreased expression of PPARA protein		 CTD PMID:30203046 PMID:36347327 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions		 ISO Isoniazid results in decreased expression of PPARG mRNA
[Isoniazid co-treated with Rifampin] results in decreased expression of PPARG protein
Isoniazid results in decreased expression of PPARG mRNA; Isoniazid results in decreased expression of PPARG protein		 CTD PMID:24128855 PMID:36347327 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression
multiple interactions		 ISO Isoniazid results in decreased expression of PPARGC1A protein
acadesine inhibits the reaction [Isoniazid results in decreased expression of PPARGC1A protein]		 CTD PMID:28556920 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656 		JBrowse link
G Psen1 presenilin 1 affects expression ISO Isoniazid affects the expression of PSEN1 mRNA CTD PMID:24848797 NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Isoniazid results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A affects expression ISO Isoniazid affects the expression of SDHA mRNA CTD PMID:24848797 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B affects expression ISO Isoniazid affects the expression of SDHB mRNA CTD PMID:24848797 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293 		JBrowse link
G Sdhd succinate dehydrogenase complex subunit D affects expression ISO Isoniazid affects the expression of SDHD mRNA CTD PMID:24848797 NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238 		JBrowse link
G Sfn stratifin decreases expression ISO Isoniazid results in decreased expression of SFN mRNA CTD PMID:30008028 NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO acadesine inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein]; Quercetin inhibits the reaction [Isoniazid results in decreased expression of SIRT1 protein] CTD PMID:28556920 PMID:31332904 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
multiple interactions		 EXP
ISO		 Isoniazid results in decreased expression of SLC10A1 mRNA
Isoniazid results in decreased expression of SLC10A1 protein
[Rifampin co-treated with Isoniazid] results in decreased expression of SLC10A1 protein
[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in increased expression of SLC10A1
obeticholic acid promotes the reaction [Isoniazid results in decreased expression of SLC10A1 mRNA]		 CTD PMID:25886055 PMID:32673658 PMID:35835356 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 affects expression EXP Isoniazid affects the expression of SLC11A1 mRNA CTD PMID:20623750 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions EXP [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 mRNA; [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein; HIF1A protein affects the reaction [[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] results in decreased expression of SLC7A11 protein] CTD PMID:36878459 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slc7a5 solute carrier family 7 member 5 decreases expression ISO Isoniazid results in decreased expression of SLC7A5 mRNA CTD PMID:30008028 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases expression EXP Isoniazid results in decreased expression of SLCO1B1 mRNA CTD PMID:32673658 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Isoniazid results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453 		JBrowse link
G Sod1 superoxide dismutase 1 increases expression ISO Isoniazid results in increased expression of SOD1 mRNA CTD PMID:33771660 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
affects expression		 EXP
ISO		 [SOD2 co-treated with CYP3A4] affects the susceptibility to Isoniazid
Isoniazid affects the expression of SOD2 mRNA		 CTD PMID:19501153 PMID:24848797 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Spp1 secreted phosphoprotein 1 affects expression
decreases expression		 EXP
ISO		 Isoniazid affects the expression of SPP1 mRNA
Isoniazid results in decreased expression of SPP1 mRNA		 CTD PMID:20623750 PMID:30008028 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Isoniazid results in increased expression of SRXN1 mRNA CTD PMID:28444390 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448 		JBrowse link
G Surf1 SURF1, cytochrome c oxidase assembly factor affects expression ISO Isoniazid affects the expression of SURF1 mRNA CTD PMID:24848797 NCBI chr 3:10,241,793...10,244,686
Ensembl chr 3:10,241,837...10,263,315 		JBrowse link
G Tf transferrin increases expression EXP Isoniazid results in increased expression of TF mRNA CTD PMID:12883083 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
increases secretion		 EXP
ISO		 Isoniazid results in increased expression of TNF protein
[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein; chrysin inhibits the reaction [Isoniazid results in increased expression of TNF protein]; Isoniazid promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Silybin inhibits the reaction [[Isoniazid co-treated with Zidovudine] results in increased expression of TNF protein]
Isoniazid results in increased secretion of TNF protein		 CTD PMID:25331106 PMID:28444390 PMID:28619387 PMID:33121995 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tpo thyroid peroxidase decreases activity EXP Isoniazid results in decreased activity of TPO protein CTD PMID:26884060 NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199 		JBrowse link
G Trak1 trafficking kinesin protein 1 affects expression ISO Isoniazid affects the expression of TRAK1 mRNA CTD PMID:24848797 NCBI chr 8:120,984,445...121,139,357
Ensembl chr 8:120,984,431...121,139,367 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO Isoniazid results in increased expression of TRIB3 mRNA CTD PMID:30008028 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497 		JBrowse link
G Txn2 thioredoxin 2 affects expression ISO Isoniazid affects the expression of TXN2 mRNA CTD PMID:24848797 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Isoniazid results in increased expression of TXNRD1 mRNA CTD PMID:28444390 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863 		JBrowse link
G Txnrd2 thioredoxin reductase 2 affects expression ISO Isoniazid affects the expression of TXNRD2 mRNA CTD PMID:24848797 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156 		JBrowse link
G Uqcrb ubiquinol-cytochrome c reductase binding protein affects expression ISO Isoniazid affects the expression of UQCRB mRNA CTD PMID:24848797 NCBI chr 7:63,814,784...63,820,150
Ensembl chr 7:63,814,797...63,820,150 		JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 affects expression ISO Isoniazid affects the expression of UQCRC2 mRNA CTD PMID:24848797 NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453 		JBrowse link
isonicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bglap bone gamma-carboxyglutamate protein increases expression EXP
ISO		 isonicotinamide results in increased expression of BGLAP mRNA CTD PMID:16813520 PMID:21745208 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Fabp4 fatty acid binding protein 4 decreases expression
increases expression		 ISO isonicotinamide results in decreased expression of FABP4 mRNA
isonicotinamide results in increased expression of FABP4 mRNA		 CTD PMID:16813520 NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO isonicotinamide results in decreased expression of PPARG mRNA CTD PMID:16813520 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression ISO isonicotinamide results in increased expression of RUNX2 mRNA CTD PMID:21745208 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sirt1 sirtuin 1 increases activity
increases expression		 ISO isonicotinamide results in increased activity of SIRT1 protein
isonicotinamide results in increased expression of SIRT1 mRNA		 CTD PMID:21745208 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sp7 Sp7 transcription factor increases expression ISO isonicotinamide results in increased expression of SP7 mRNA CTD PMID:21745208 NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO isonicotinamide results in increased expression of SPP1 mRNA CTD PMID:21745208 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162 		JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B increases expression ISO isonicotinamide results in increased expression of TNFRSF11B mRNA CTD PMID:16813520 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538 		JBrowse link
N'-acetylisoniazid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase increases oxidation ISO MPO protein results in increased oxidation of (N)1-acetylisoniazid CTD PMID:26867495 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      biological role 19805
        biochemical role 19515
          metabolite 19502
            eukaryotic metabolite 19319
              algal metabolite 15575
                isonicotinic acid 174
                  2-[4-(\{2-[(2S,5R)-2-(aminomethyl)-5-ethynylpyrrolidin-1-yl]-2-oxoethyl\}amino)-4-methylpiperidin-1-yl]isonicotinic acid 0
                  2-ethylisonicotinic acid 0
                  4-pyridoxic acid + 1
                  isoniazide + 168
                  isonicotinamide + 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            heteroorganic entity 19477
                              organochalcogen compound 19240
                                organooxygen compound 19155
                                  carbon oxoacid 18613
                                    carboxylic acid 18610
                                      monocarboxylic acid 17966
                                        pyridinemonocarboxylic acid 417
                                          isonicotinic acid 174
                                            2-[4-(\{2-[(2S,5R)-2-(aminomethyl)-5-ethynylpyrrolidin-1-yl]-2-oxoethyl\}amino)-4-methylpiperidin-1-yl]isonicotinic acid 0
                                            2-ethylisonicotinic acid 0
                                            4-pyridoxic acid + 1
                                            isoniazide + 168
                                            isonicotinamide + 8
paths to the root