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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 3.4.* (hydrolases acting on peptide bond) inhibitor
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Accession:CHEBI:60258 term browser browse the term
Definition:A hydrolase inhibitor that interferes with the action of any hydrolase acting on peptide bonds (peptidase), EC 3.4.*.*).
Synonyms:related_synonym: EC 3.4.* (hydrolase acting on peptide bond) inhibitor;   EC 3.4.* (hydrolase acting on peptide bonds) inhibitors;   EC 3.4.* (hydrolases acting on peptide bond) inhibitors;   EC 3.4.* (peptidase) inhibitor;   EC 3.4.* (peptidase) inhibitors;   EC 3.4.* inhibitor;   EC 3.4.* inhibitors;   inhibitor of hydrolases acting on peptide bond (EC 3.4.*);   inhibitors of hydrolases acting on peptide bond (EC 3.4.*);   peptidase inhibitors;   protease inhibitor;   protease inhibitors
 alt_id: CHEBI:76763



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1,10-phenanthroline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANPEP alanyl aminopeptidase, membrane multiple interactions
decreases activity
EXP Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881
JBrowse link
G ENPEP glutamyl aminopeptidase multiple interactions EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
ageladine A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CSNK1A1 casein kinase 1 alpha 1 decreases activity
affects activity
EXP Ageladine A analog results in decreased activity of CSNK1A1 protein
Ageladine A affects the activity of CSNK1A1 protein
CTD PMID:21413800 NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,077...150,662,284
JBrowse link
amastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions EXP amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
amprenavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression EXP amprenavir results in decreased expression of NOS3 mRNA CTD PMID:16123675 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP benazepril results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
JBrowse link
chlorpromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP Chlorpromazine results in decreased activity of DAO protein CTD PMID:18615285 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633
JBrowse link
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases oxidation EXP FMO1 protein results in increased oxidation of Chlorpromazine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
JBrowse link
cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein] CTD PMID:20435919 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
JBrowse link
G CASP8 caspase 8 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein] CTD PMID:20435919 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468
JBrowse link
G FASLG Fas ligand multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein] CTD PMID:20435919 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464
JBrowse link
ebselen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP4A ATPase H+/K+ transporting subunit alpha multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552
JBrowse link
G ATP4B ATPase H+/K+ transporting subunit beta multiple interactions EXP ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein] CTD PMID:7590103 NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116
JBrowse link
embelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions EXP [embelin results in increased uptake of Calcium] which results in increased activity of NOS3 protein CTD PMID:20144727 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Enalapril affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
enalaprilat dihydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases activity EXP Enalaprilat results in decreased activity of AGT protein modified form CTD PMID:7890486 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833
JBrowse link
G KNG1 kininogen 1 increases activity EXP Enalaprilat results in increased activity of KNG1 protein modified form CTD PMID:7890486 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958
JBrowse link
imipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases oxidation EXP FMO1 protein results in increased oxidation of Imipramine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076
JBrowse link
menadione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATF6 activating transcription factor 6 multiple interactions
increases activity
EXP SOD2 inhibits the reaction [Vitamin K 3 results in increased activity of ATF6 protein] CTD PMID:18086661 NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304
JBrowse link
G CAPN2 calpain 2 increases expression
increases cleavage
EXP Vitamin K 3 results in increased expression of CAPN2 protein
Vitamin K 3 results in increased cleavage of CAPN2 protein
CTD PMID:16920763 NCBI chr10:19,758,824...19,820,241
Ensembl chr10:19,758,757...19,820,246
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions
increases expression
EXP PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSP90B1 protein]
Vitamin K 3 results in increased expression of HSP90B1 mRNA; Vitamin K 3 results in increased expression of HSP90B1 protein
CTD PMID:16920763 PMID:18086661 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions
increases expression
EXP PD 150606 inhibits the reaction [Vitamin K 3 results in increased expression of HSPA5 protein]
Vitamin K 3 results in increased expression of HSPA5 mRNA; Vitamin K 3 results in increased expression of HSPA5 protein
CTD PMID:16920763 PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation EXP Vitamin K 3 results in increased phosphorylation of MAPK8 protein CTD PMID:18086661 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874
JBrowse link
G SOD2 superoxide dismutase 2 decreases response to substance
multiple interactions
EXP SOD2 results in decreased susceptibility to Vitamin K 3
SOD2 inhibits the reaction [Vitamin K 3 results in increased activity of ATF6 protein]
CTD PMID:18086661 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560
JBrowse link
G TPO thyroid peroxidase decreases activity EXP Vitamin K 3 results in decreased activity of TPO protein CTD PMID:11815678 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208
JBrowse link
G XBP1 X-box binding protein 1 increases splicing EXP Vitamin K 3 results in increased splicing of XBP1 mRNA CTD PMID:18086661 NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526
JBrowse link
pepstatin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LTA4H leukotriene A4 hydrolase decreases activity EXP pepstatin results in decreased activity of LTA4H protein CTD PMID:21670530 NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515
JBrowse link
G PGA5 pepsinogen 5, group I (pepsinogen A) decreases activity EXP pepstatin analog results in decreased activity of PGA5 protein CTD PMID:1478780 NCBI chr 2:10,244,300...10,252,644
Ensembl chr 2:10,244,187...10,252,680
JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]; Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 protein]; Ritonavir results in decreased expression of and results in decreased activity of NOS3 protein
Ritonavir results in decreased expression of NOS3 mRNA; Ritonavir results in decreased expression of NOS3 protein
CTD PMID:15681703 PMID:16123675 PMID:22037733 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
rosmarinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP Rosmarinic Acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998
JBrowse link
saquinavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression EXP Saquinavir results in decreased expression of NOS3 mRNA CTD PMID:16123675 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of HMGCR mRNA]
Simvastatin results in decreased expression of HMGCR mRNA
CTD PMID:17130282 PMID:19343539 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,224...84,402,957
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions
increases expression
EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of LDLR mRNA]
Simvastatin results in increased expression of LDLR mRNA
CTD PMID:17130282 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,827
JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of NPC1L1 mRNA] CTD PMID:17130282 NCBI chr18:50,726,854...50,757,676
Ensembl chr18:50,726,922...50,757,649
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 decreases expression EXP Simvastatin results in decreased expression of NR4A3 mRNA CTD PMID:16005304 NCBI chr 1:241,569,867...241,611,735
Ensembl chr 1:241,570,010...241,611,727
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Ezetimibe co-treated with Simvastatin] results in increased expression of SREBF1 mRNA CTD PMID:17130282 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of SREBF2 mRNA] CTD PMID:17130282 NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,490...6,784,671
JBrowse link
verapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5059
    role 5022
      biological role 5022
        biochemical role 4942
          enzyme inhibitor 492
            EC 3.* (hydrolase) inhibitor 429
              EC 3.4.* (hydrolases acting on peptide bond) inhibitor 31
                (1S,2R,5S)-5-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-2-(2,4,5-trifluorophenyl)cyclohexanamine 0
                EC 3.4.11.* (aminopeptidase) inhibitor + 1
                EC 3.4.13.* (dipeptidase) inhibitor + 3
                EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor + 0
                EC 3.4.15.* (peptidyl-dipeptidase) inhibitor + 2
                EC 3.4.17* (metallocarboxypeptidase) inhibitor + 0
                EC 3.4.19.* (omega-peptidase) inhibitor + 2
                EC 3.4.21.* (serine endopeptidase) inhibitor + 3
                EC 3.4.22.* (cysteine endopeptidase) inhibitor + 10
                EC 3.4.23.* (aspartic endopeptidase) inhibitor + 2
                EC 3.4.24.* (metalloendopeptidase) inhibitor + 7
                [(R)-1-L-prolylpyrrolidin-2-yl]boronic acid 0
                matrix metalloproteinase inhibitor + 1
                protease inhibitor + 13
paths to the root