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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:purine deoxyribonucleoside
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Accession:CHEBI:60173 term browser browse the term
Definition:A deoxyribonucleoside containing a purine base.
Synonyms:related_synonym: purine deoxyribonucleosides


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2',3'-dideoxyadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions EXP Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid affects the localization of ABCC2 protein]; Dideoxyadenosine inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein] CTD PMID:25813982 PMID:31300867 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Egf epidermal growth factor multiple interactions EXP Dideoxyadenosine inhibits the reaction [[EGF protein co-treated with 1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone] results in decreased activity of ABCC2 protein] CTD PMID:25813982 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
2'-deoxyadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO 2'-deoxyadenosine results in decreased expression of CDKN1A mRNA CTD PMID:24211769 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Polb DNA polymerase beta multiple interactions ISO [diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLB protein CTD PMID:26098310 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
JBrowse link
G Poli DNA polymerase iota multiple interactions ISO [diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein; POLN protein inhibits the reaction [[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein] CTD PMID:26098310 NCBI chr18:64,116,774...64,134,373
Ensembl chr18:64,116,774...64,163,418
JBrowse link
G Polk DNA polymerase kappa multiple interactions ISO [diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLK protein CTD PMID:26098310 NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313
JBrowse link
G Poln DNA polymerase nu multiple interactions ISO [diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLN protein; POLN protein inhibits the reaction [[diepoxybutane binds to 2'-deoxyadenosine] which results in decreased activity of POLI protein] CTD PMID:26098310 NCBI chr14:76,579,983...76,752,460 JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions ISO 2'-deoxyadenosine inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO 2'-deoxyadenosine inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine] CTD PMID:11085929 NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171
JBrowse link
2'-deoxyguanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein; Deoxycytidine inhibits the reaction [[9-deaza-9-(3-thienylmethyl)guanine co-treated with Deoxyguanosine] results in increased activity of CASP3 protein] CTD PMID:9297556 PMID:9403342 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO CYP1A1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO CYP1B1 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO CYP3A4 protein promotes the reaction [Aflatoxin B1 binds to Deoxyguanosine]; CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] CTD PMID:21907773 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases activity ISO Deoxyguanosine analog results in decreased activity of MGMT protein CTD PMID:17880193 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
8,5'-cyclo-2'-deoxyadenosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Neil1 nei-like DNA glycosylase 1 affects metabolic processing ISO NEIL1 protein affects the metabolism of 8,5'-cyclo-2'-deoxyadenosine CTD PMID:20067321 NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258
JBrowse link
cladribine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of BCL2 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of BCL2 protein; BCL2 affects the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP9 protein]; BCL2 inhibits the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP3 protein]; BCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]
Cladribine results in decreased expression of BCL2 protein
CTD PMID:15516989 PMID:15582267 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of BIRC3 protein] CTD PMID:12948851 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO BCL2 inhibits the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP3 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP3 protein]; Cladribine results in increased cleavage of and results in increased activity of CASP3 protein
Cladribine results in increased activity of CASP3 protein
CTD PMID:11672427 PMID:12948851 PMID:15516989 PMID:21679466 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 multiple interactions
increases activity
ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP6 protein]
Cladribine results in increased activity of CASP6 protein
CTD PMID:11672427 PMID:12948851 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP7 protein]
Cladribine results in increased activity of CASP7 protein
CTD PMID:12948851 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions
increases activity
increases cleavage
ISO [Valproic Acid co-treated with Cladribine] results in increased cleavage of CASP8 protein; BCL2 inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Cladribine results in increased cleavage of CASP8 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP8 protein]
Cladribine results in increased activity of CASP8 protein
CTD PMID:11672427 PMID:12948851 PMID:15516989 PMID:19006566 PMID:21679466 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO BCL2 affects the reaction [Cladribine results in increased cleavage of and results in increased activity of CASP9 protein]; Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased activity of CASP9 protein]; Cladribine results in increased cleavage of and results in increased activity of CASP9 protein
Cladribine results in increased activity of CASP9 protein
CTD PMID:11672427 PMID:12948851 PMID:15516989 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
ISO Cladribine results in increased expression of CDKN1A mRNA
Cladribine promotes the reaction [resveratrol results in increased expression of CDKN1A mRNA]; resveratrol promotes the reaction [Cladribine results in increased expression of CDKN1A mRNA]
CTD PMID:21801466 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Daxx death-domain associated protein multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of DAXX protein] CTD PMID:12948851 NCBI chr20:4,970,090...4,976,145
Ensembl chr20:4,970,092...4,975,843
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in increased localization of DIABLO protein] CTD PMID:12948851 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases expression
ISO Cholecalciferol promotes the reaction [Cladribine results in decreased expression of DNMT1 mRNA]; Cladribine promotes the reaction [Cholecalciferol results in decreased expression of DNMT1 mRNA] CTD PMID:21801466 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Il4 interleukin 4 increases expression ISO Cladribine results in increased expression of IL4 mRNA CTD PMID:9751108 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Kmt2a lysine methyltransferase 2A increases response to substance ISO KMT2A gene mutant form results in increased susceptibility to Cladribine CTD PMID:14712291 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Lmnb1 lamin B1 multiple interactions
increases cleavage
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of LMNB1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of LMNB1 protein
Cladribine results in increased cleavage of LMNB1 protein
CTD PMID:15582267 NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502
JBrowse link
G Nt5c1a 5'-nucleotidase, cytosolic IA decreases response to substance
multiple interactions
ISO NT5C1A protein results in decreased susceptibility to Cladribine
NT5C1A protein results in decreased susceptibility to [Fluorouracil co-treated with Cladribine]
CTD PMID:16362297 NCBI chr 5:135,473,107...135,494,400
Ensembl chr 5:135,473,231...135,499,338
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO [Cladribine co-treated with Cyclophosphamide co-treated with Mitoxantrone] results in decreased expression of PARP1 protein; [Cladribine co-treated with Cyclophosphamide] results in decreased expression of PARP1 protein
Cladribine results in increased cleavage of PARP1 protein
CTD PMID:15582267 PMID:21679466 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pawr pro-apoptotic WT1 regulator multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of PAWR protein] CTD PMID:12948851 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
decreases methylation
increases expression
ISO Cholecalciferol promotes the reaction [Cladribine results in increased expression of PTEN mRNA]; Cholecalciferol promotes the reaction [Cladribine results in increased methylation of PTEN promoter]; Cladribine promotes the reaction [Cholecalciferol results in decreased methylation of PTEN promoter]; Cladribine promotes the reaction [Cholecalciferol results in increased expression of PTEN mRNA]; resveratrol promotes the reaction [Cladribine results in decreased methylation of PTEN promoter] CTD PMID:21801466 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation ISO Cladribine results in increased phosphorylation of STAT3 protein CTD PMID:21679466 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Cladribine results in increased expression of TNF protein CTD PMID:10540334 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Xiap X-linked inhibitor of apoptosis multiple interactions ISO Cladribine promotes the reaction [Bendamustine Hydrochloride results in decreased expression of XIAP protein] CTD PMID:12948851 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
didanosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Didanosine binds to ALB protein CTD PMID:15814459 PMID:16336266 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Hfe homeostatic iron regulator multiple interactions ISO HFE gene SNP affects the susceptibility to [Didanosine co-treated with Stavudine] CTD PMID:16847405 NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502
JBrowse link
G Il24 interleukin 24 decreases expression ISO Didanosine results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II decreases expression
multiple interactions
ISO Didanosine results in decreased expression of COX2 mRNA
tenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA]
CTD PMID:16940060 Ensembl chr MT:7,006...7,689 JBrowse link
G Slc29a3 solute carrier family 29 member 3 affects transport ISO SLC29A3 protein affects the transport of Didanosine CTD PMID:19164483 NCBI chr20:28,645,265...28,685,388
Ensembl chr20:28,647,391...28,685,388
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor increases expression ISO Didanosine results in increased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    chemical entity 19812
      atom 19811
        nonmetal atom 19698
          nitrogen atom 18761
            nitrogen molecular entity 18761
              nucleobase-containing molecular entity 5376
                nucleoside 5376
                  deoxyribonucleoside 2735
                    purine deoxyribonucleoside 41
                      purine 2',3'-dideoxyribonucleoside + 8
                      purine 2'-deoxyribonucleoside + 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            heteroorganic entity 19283
                              organochalcogen compound 19054
                                organooxygen compound 19004
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11945
                                        glycosyl compound 10978
                                          N-glycosyl compound 5515
                                            nucleoside 5376
                                              deoxyribonucleoside 2735
                                                purine deoxyribonucleoside 41
                                                  purine 2',3'-dideoxyribonucleoside + 8
                                                  purine 2'-deoxyribonucleoside + 33
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