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G |
AHR |
aryl hydrocarbon receptor |
multiple interactions |
EXP |
[Chlorodiphenyl (54% Chlorine) binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
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NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
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G |
CYP1A1 |
cytochrome P450 family 1 subfamily A member 1 |
multiple interactions |
EXP |
[Chlorodiphenyl (54% Chlorine) binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein |
CTD |
PMID:24389113 |
|
NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
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G |
ACHE |
acetylcholinesterase |
multiple interactions |
EXP |
[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] |
CTD |
PMID:16915560 |
|
NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
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G |
SCT |
secretin |
multiple interactions |
EXP |
Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] |
CTD |
PMID:3562434 |
|
|
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G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
hexaconazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
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G |
SLC47A2 |
solute carrier family 47 member 2 |
decreases activity |
EXP |
hexaconazole results in decreased activity of SLC47A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
affects abundance increases response to substance multiple interactions |
EXP |
ABCB1 protein affects the abundance of Ivermectin ABCB1 gene mutant form results in increased susceptibility to Ivermectin; ABCB1 mutant form results in increased susceptibility to Ivermectin; ABCB1 protein mutant form results in increased susceptibility to Ivermectin ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA] |
CTD |
PMID:20595473 PMID:22834856 PMID:22924731 PMID:23186803 PMID:25419811 |
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NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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G |
ALB |
albumin |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709
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G |
DAO |
D-amino acid oxidase |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238
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G |
EBF3 |
EBF transcription factor 3 |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022
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G |
GABRQ |
gamma-aminobutyric acid type A receptor subunit theta |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr X:120,607,815...120,630,251
Ensembl chr X:120,607,686...120,628,343
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G |
GLRA1 |
glycine receptor alpha 1 |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376
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G |
KLK6 |
kallikrein related peptidase 6 |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr 1:105,902,147...105,907,585
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G |
MAB21L2 |
mab-21 like 2 |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034
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G |
SLC10A4 |
solute carrier family 10 member 4 |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732
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G |
SLC18A2 |
solute carrier family 18 member A2 |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993
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G |
TTR |
transthyretin |
multiple interactions |
EXP |
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA] |
CTD |
PMID:25419811 |
|
NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
decreases expression multiple interactions decreases activity |
EXP |
Ketoconazole results in decreased expression of ABCB1 mRNA [Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi |
CTD |
PMID:19754906 PMID:22620706 |
|
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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G |
CYP3A12 |
cytochrome P-450 3A12 |
multiple interactions decreases activity |
EXP |
Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam] Ketoconazole results in decreased activity of CYP3A12 protein |
CTD |
PMID:15677349 |
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G |
SOD1 |
superoxide dismutase 1 |
affects response to substance |
EXP |
SOD1 protein affects the susceptibility to Nafenopin |
CTD |
PMID:6333936 |
|
NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
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G |
CAPN1 |
calpain 1 |
increases expression |
EXP |
Ofloxacin results in increased expression of CAPN1 mRNA |
CTD |
PMID:24582689 |
|
NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
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G |
CASP12 |
caspase 12 |
increases expression |
EXP |
Ofloxacin results in increased expression of CASP12 mRNA; Ofloxacin results in increased expression of CASP12 protein |
CTD |
PMID:24582689 |
|
NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
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G |
CASP8 |
caspase 8 |
multiple interactions increases expression |
EXP |
TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA] |
CTD |
PMID:24582689 |
|
NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
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G |
DDIT3 |
DNA damage inducible transcript 3 |
increases expression |
EXP |
Ofloxacin results in increased expression of DDIT3 mRNA |
CTD |
PMID:24582689 |
|
NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
EXP |
Ofloxacin results in increased expression of HSPA5 mRNA |
CTD |
PMID:24582689 |
|
NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
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G |
TNF |
tumor necrosis factor |
increases expression |
EXP |
Ofloxacin results in increased expression of TNF mRNA; Ofloxacin results in increased expression of TNF protein |
CTD |
PMID:24582689 |
|
NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
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G |
TNFRSF1A |
TNF receptor superfamily member 1A |
multiple interactions increases expression |
EXP |
TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA] Ofloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A protein |
CTD |
PMID:24582689 |
|
NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
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G |
TRADD |
TNFRSF1A associated via death domain |
multiple interactions increases expression |
EXP |
TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA] |
CTD |
PMID:24582689 |
|
NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963
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G |
NR1I2 |
nuclear receptor subfamily 1 group I member 2 |
increases activity |
EXP |
Omeprazole results in increased activity of NR1I2 protein |
CTD |
PMID:27732639 |
|
NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
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G |
SLC22A6 |
solute carrier family 22 member 6 |
multiple interactions |
EXP |
[Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican |
CTD |
PMID:36243147 |
|
NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396
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G |
SLC22A2 |
solute carrier family 22 member 2 |
decreases activity |
EXP |
penconazole results in decreased activity of SLC22A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435
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G |
SLC22A5 |
solute carrier family 22 member 5 |
decreases activity |
EXP |
penconazole results in decreased activity of SLC22A5 protein |
CTD |
PMID:36669674 |
|
NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087
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G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
penconazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
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G |
SLC47A2 |
solute carrier family 47 member 2 |
decreases activity |
EXP |
penconazole results in decreased activity of SLC47A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136
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G |
SCT |
secretin |
decreases abundance |
EXP |
SCT protein results in decreased abundance of Lactic Acid |
CTD |
PMID:2418308 |
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G |
ATP2A2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
affects expression multiple interactions |
EXP |
Ranolazine affects the expression of ATP2A2 protein [Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein; [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein |
CTD |
PMID:18820026 |
|
NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388
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G |
EGR1 |
early growth response 1 |
multiple interactions affects expression |
EXP |
[Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein Ranolazine affects the expression of EGR1 protein |
CTD |
PMID:18820026 |
|
NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
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G |
GATA4 |
GATA binding protein 4 |
affects expression multiple interactions |
EXP |
Ranolazine affects the expression of GATA4 protein [Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein; [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein |
CTD |
PMID:18820026 |
|
NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
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G |
NAB1 |
NGFI-A binding protein 1 |
affects expression multiple interactions |
EXP |
Ranolazine affects the expression of NAB1 protein [Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein |
CTD |
PMID:18820026 |
|
NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610
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G |
SLC8A1 |
solute carrier family 8 member A1 |
affects expression multiple interactions |
EXP |
Ranolazine affects the expression of SLC8A1 protein [Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein |
CTD |
PMID:18820026 |
|
NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
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G |
ACHE |
acetylcholinesterase |
decreases activity multiple interactions |
EXP |
Sarin results in decreased activity of ACHE protein [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein] |
CTD |
PMID:16915560 |
|
NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
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G |
BCHE |
butyrylcholinesterase |
decreases activity |
EXP |
Sarin results in decreased activity of BCHE protein |
CTD |
PMID:16915560 |
|
NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
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G |
SLC22A2 |
solute carrier family 22 member 2 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC22A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435
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G |
SLC22A5 |
solute carrier family 22 member 5 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC22A5 protein |
CTD |
PMID:36669674 |
|
NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087
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G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
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G |
SLC47A2 |
solute carrier family 47 member 2 |
decreases activity |
EXP |
tebuconazole results in decreased activity of SLC47A2 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136
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G |
SLC22A5 |
solute carrier family 22 member 5 |
decreases activity |
EXP |
triticonazole results in decreased activity of SLC22A5 protein |
CTD |
PMID:36669674 |
|
NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087
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G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
triticonazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
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G |
HSP90B1 |
heat shock protein 90 beta family member 1 |
increases expression |
EXP |
Tunicamycin results in increased expression of HSP90B1 protein |
CTD |
PMID:17416481 |
|
NCBI chr15:42,456,793...42,474,122
Ensembl chr15:42,456,764...42,579,311
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G |
HSPA5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
EXP |
Tunicamycin results in increased expression of HSPA5 protein |
CTD |
PMID:17416481 |
|
NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
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G |
SLC22A5 |
solute carrier family 22 member 5 |
decreases activity |
EXP |
uniconazole results in decreased activity of SLC22A5 protein |
CTD |
PMID:36669674 |
|
NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087
|
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G |
SLC47A1 |
solute carrier family 47 member 1 |
decreases activity |
EXP |
uniconazole results in decreased activity of SLC47A1 protein |
CTD |
PMID:36669674 |
|
NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946
|
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G |
ABCB1 |
ATP binding cassette subfamily B member 1 |
multiple interactions |
EXP |
[Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin |
CTD |
PMID:20510202 |
|
NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
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G |
CYP2B6 |
cytochrome P450 2B11 |
increases hydroxylation |
EXP |
CYP2B6 protein results in increased hydroxylation of Warfarin |
CTD |
PMID:12637241 |
|
NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
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G |
CYP3A12 |
cytochrome P-450 3A12 |
increases hydroxylation |
EXP |
CYP3A12 protein results in increased hydroxylation of Warfarin |
CTD |
PMID:12637241 |
|
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