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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:chemical substance
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Accession:CHEBI:59999 term browser browse the term
Definition:A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types.
Synonyms:related_synonym: Chemische Substanz


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crocidolite asbestos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLAU plasminogen activator, urokinase increases activity
multiple interactions
increases expression
EXP Asbestos, Crocidolite results in increased activity of PLAU protein
[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein; Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]
Asbestos, Crocidolite results in increased expression of PLAU mRNA
CTD PMID:9853007 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
JBrowse link
G PLG plasminogen increases cleavage
multiple interactions
EXP Asbestos, Crocidolite results in increased cleavage of PLG protein
[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein; Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of PLG protein]
CTD PMID:9853007 NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,191...7,110,555
JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 decreases expression EXP Ivermectin results in decreased expression of CCND1 mRNA CTD PMID:31400776 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP Ivermectin results in decreased expression of CCNE1 mRNA CTD PMID:31400776 NCBI chr 6:39,919,541...39,933,224
Ensembl chr 6:39,919,624...39,933,366
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK1 protein] CTD PMID:31400776 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK3 protein] CTD PMID:31400776 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP pyrazolanthrone promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK8 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK8 protein] CTD PMID:31400776 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP pyrazolanthrone promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK9 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK9 protein] CTD PMID:31400776 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP Ivermectin results in decreased expression of PCNA mRNA; Ivermectin results in decreased expression of PCNA protein CTD PMID:31400776 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP Wortmannin promotes the reaction [Ivermectin results in decreased phosphorylation of RPS6 protein] CTD PMID:31400776 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468
JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of RPS6KA1 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of RPS6KA1 protein] CTD PMID:31400776 NCBI chr 6:83,905,124...83,947,189
Ensembl chr 6:83,905,076...83,950,984
JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 3A29 multiple interactions EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121 JBrowse link
malathion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT2 AKT serine/threonine kinase 2 increases expression EXP Malathion results in increased expression of AKT2 mRNA CTD PMID:31535366 NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,789...48,587,919
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Malathion results in increased expression of BAX mRNA CTD PMID:31535366 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP Malathion results in decreased expression of BCL2 mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]
CTD PMID:31535366 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CAT catalase decreases expression
multiple interactions
EXP Malathion results in decreased expression of CAT mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA]
CTD PMID:31535366 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CYP1A1 cytochrome P450 1A1 decreases expression EXP Malathion results in decreased expression of CYP1A1 mRNA CTD PMID:31535366 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G DUOX2 dual oxidase 2 decreases expression EXP Malathion results in decreased expression of DUOX2 mRNA CTD PMID:31535366 NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,477...126,641,419
JBrowse link
G GPX4 glutathione peroxidase 4 increases expression EXP Malathion results in increased expression of GPX4 mRNA CTD PMID:31535366 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886
JBrowse link
G GPX6 glutathione peroxidase 6 increases expression EXP Malathion results in increased expression of GPX6 mRNA CTD PMID:31535366 NCBI chr 7:22,256,013...22,267,992
Ensembl chr 7:22,256,038...22,267,992
JBrowse link
G LOC100625479 cytochrome P450 1B1 decreases expression EXP Malathion results in decreased expression of CYP1B1 mRNA CTD PMID:31535366 NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,206,750
JBrowse link
G MT-CO1 mitochondrially encoded cytochrome c oxidase I affects expression EXP Malathion affects the expression of COX1 mRNA CTD PMID:17454254 NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055
JBrowse link
G MT-CO3 mitochondrially encoded cytochrome c oxidase III affects expression EXP Malathion affects the expression of COX3 mRNA CTD PMID:17454254 NCBI chr MT:9,800...10,583
Ensembl chr MT:9,800...10,583
JBrowse link
G PLIN2 perilipin 2 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein]
Malathion results in decreased expression of PLIN2 mRNA; Malathion results in decreased expression of PLIN2 protein
CTD PMID:31535366 NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,274
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein]
Malathion results in decreased expression of PPARG mRNA; Malathion results in decreased expression of PPARG protein
CTD PMID:31535366 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G SLC34A2 solute carrier family 34 member 2 increases expression EXP Malathion results in increased expression of SLC34A2 mRNA CTD PMID:31535366 NCBI chr 8:19,481,127...19,507,903
Ensembl chr 8:19,481,198...19,509,667
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Malathion results in increased expression of SOD2 mRNA CTD PMID:31535366 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G SORD sorbitol dehydrogenase increases expression EXP Malathion results in increased expression of SORD mRNA CTD PMID:31535366 NCBI chr 1:126,659,198...126,701,084
Ensembl chr 1:126,655,135...126,700,858
JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions
EXP Malathion results in increased expression of TP53 mRNA
Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
CTD PMID:31535366 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
metolachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B22 cytochrome P450 2B22 multiple interactions EXP CYP2B22 protein results in increased metabolism of and results in decreased susceptibility to metolachlor CTD PMID:16315095 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,413
JBrowse link
nicotine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein] CTD PMID:28506824 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G ADCYAP1R1 ADCYAP receptor type I decreases expression EXP Nicotine results in decreased expression of ADCYAP1R1 protein CTD PMID:28506824 NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,402...41,972,301
JBrowse link
G AMH anti-Mullerian hormone decreases expression
decreases secretion
EXP Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein
CTD PMID:32423882 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,405,253...76,418,312
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Nicotine results in decreased expression of BCL2 mRNA CTD PMID:32423882 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein] CTD PMID:28235547 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,191,842...11,207,381
JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein] CTD PMID:28235547 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,778...47,384,303
JBrowse link
G CHRNA7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein] CTD PMID:28235547 NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,698...142,937,788
JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein] CTD PMID:28235547 NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384
JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein] CTD PMID:28235547 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037
JBrowse link
G CYP19A2 cytochrome P450 19A2 decreases expression EXP Nicotine results in decreased expression of CYP19A1 mRNA CTD PMID:32423882 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G FSHR follicle stimulating hormone receptor decreases expression EXP Nicotine results in decreased expression of FSHR mRNA CTD PMID:32423882 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G INHBB inhibin subunit beta B decreases expression
decreases secretion
EXP Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein
CTD PMID:32423882 NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of ITGB1 mRNA CTD PMID:32423882 NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,398...56,173,795
JBrowse link
G LAMB1 laminin subunit beta 1 decreases expression EXP Nicotine results in decreased expression of LAMB1 mRNA CTD PMID:32423882 NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases expression
decreases phosphorylation
EXP Nicotine results in decreased expression of MAPK1 mRNA
Nicotine results in decreased phosphorylation of MAPK1 protein
CTD PMID:32423882 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
decreases expression
EXP Nicotine results in decreased phosphorylation of MAPK3 protein
Nicotine results in decreased expression of MAPK3 mRNA
CTD PMID:32423882 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 decreases expression
decreases phosphorylation
EXP Nicotine results in decreased expression of MAPK8 mRNA
Nicotine results in decreased phosphorylation of MAPK8 protein
CTD PMID:32423882 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression EXP Nicotine results in increased expression of MMP9 mRNA CTD PMID:32423882 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
G OCLN occludin decreases expression EXP Nicotine results in decreased expression of OCLN mRNA CTD PMID:32423882 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,498...47,654,033
JBrowse link
G RPP38 ribonuclease P/MRP subunit p38 decreases expression EXP Nicotine results in decreased expression of RPP38 mRNA CTD PMID:32423882 NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,195...46,725,920
JBrowse link
sarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity
multiple interactions
EXP Sarin results in decreased activity of ACHE protein
asoxime chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Sarin results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Sarin results in decreased activity of ACHE protein]
CTD PMID:16021679, PMID:19428926, PMID:20156534, PMID:20888357, PMID:22230262, PMID:22343375 NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,324...8,739,149
JBrowse link
serpentine asbestos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ICAM1 intercellular adhesion molecule 1 increases expression EXP Asbestos, Serpentine results in increased expression of ICAM1 mRNA CTD PMID:8685910 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205
JBrowse link
G PLAU plasminogen activator, urokinase multiple interactions
increases expression
increases activity
EXP [Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]
Asbestos, Serpentine results in increased expression of PLAU mRNA
CTD PMID:9853007 NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
JBrowse link
G PLAUR plasminogen activator, urokinase receptor increases expression EXP Asbestos, Serpentine results in increased expression of PLAUR protein CTD PMID:9853007 NCBI chr 6:50,489,773...50,505,453
Ensembl chr 6:50,489,777...50,505,418
JBrowse link
G PLG plasminogen increases cleavage
multiple interactions
EXP Asbestos, Serpentine results in increased cleavage of PLG protein
[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Serpentine results in increased cleavage of PLG protein]
CTD PMID:9853007 NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,191...7,110,555
JBrowse link
tunicamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Tunicamycin results in increased expression of HSP90B1 protein CTD PMID:15049342, PMID:17416481 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 decreases response to substance
increases expression
EXP HSPA5 results in decreased susceptibility to Tunicamycin
Tunicamycin results in increased expression of HSPA5 protein
CTD PMID:15049342, PMID:16920763, PMID:17416481, PMID:17464326, PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
verapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
warfarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BMP2 bone morphogenetic protein 2 multiple interactions EXP [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 mRNA; [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 protein; SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 mRNA] CTD PMID:29358327 NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,215
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of CDKN1A protein CTD PMID:29358327 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761
JBrowse link
G EP300 E1A binding protein p300 multiple interactions EXP [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of EP300 protein CTD PMID:29358327 NCBI chr 5:7,311,165...7,394,515
Ensembl chr 5:7,311,171...7,393,760
JBrowse link
G RUNX2 RUNX family transcription factor 2 multiple interactions EXP [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 mRNA; [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 protein; SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 mRNA]; SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 protein] CTD PMID:29358327 NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,513...40,459,686
JBrowse link
G SNAI2 snail family transcriptional repressor 2 multiple interactions EXP [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of SNAI2 protein; SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 mRNA]; SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 mRNA]; SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 protein]; SNAI2 protein promotes the reaction [TP53 protein results in increased susceptibility to Warfarin]; Warfarin promotes the reaction [TP53 protein binds to SNAI2 promoter] CTD PMID:29358327 NCBI chr 4:79,264,880...79,268,475
Ensembl chr 4:79,264,878...79,268,475
JBrowse link
G TP53 tumor protein p53 increases response to substance
increases expression
multiple interactions
EXP TP53 protein results in increased susceptibility to Warfarin
Warfarin results in increased expression of TP53 mRNA
[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 mRNA; [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 protein; [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of CDKN1A protein; [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of EP300 protein; [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 mRNA; [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 protein; [TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of SNAI2 protein; SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of BMP2 mRNA]; SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 mRNA]; SNAI2 protein promotes the reaction [[TP53 protein results in increased susceptibility to Warfarin] which results in increased expression of RUNX2 protein]; SNAI2 protein promotes the reaction [TP53 protein results in increased susceptibility to Warfarin]; Warfarin promotes the reaction [TP53 protein binds to SNAI2 promoter]; Warfarin results in increased expression of and results in decreased acetylation of TP53 protein
CTD PMID:29358327 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link

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  CHEBI ontology 880
    chemical entity 880
      chemical substance 57
        biogenic substance + 0
        mineral + 4
        mixture + 53
        pure substance 0
        wax + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.