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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:amphiphile
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Accession:CHEBI:59941 term browser browse the term
Definition:A surfactant molecule possessing both hydrophilic and lipophilic properties.
Synonyms:related_synonym: amphiphiles


show annotations for term's descendants           Sort by:
bupivacaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO Bupivacaine results in increased expression of BAX protein
8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one promotes the reaction [[Glucose co-treated with Bupivacaine] results in increased expression of BAX protein]; [Glucose co-treated with Bupivacaine] results in increased expression of BAX protein		 CTD PMID:31672611 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 ISO Bupivacaine results in decreased expression of BCL2 protein
8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one promotes the reaction [[Glucose co-treated with Bupivacaine] results in decreased expression of BCL2 protein]; [Glucose co-treated with Bupivacaine] results in decreased expression of BCL2 protein; HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of BCL2 protein]		 CTD PMID:31672611 PMID:34793778 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
decreases expression		 EXP MIR497 mRNA affects the reaction [Bupivacaine results in decreased expression of BDNF mRNA]; MIR497 mRNA inhibits the reaction [SNHG12 inhibits the reaction [Bupivacaine results in decreased expression of BDNF mRNA]]; NLRX1 protein affects the reaction [MIR497 mRNA affects the reaction [Bupivacaine results in decreased expression of BDNF mRNA]]; SNHG12 inhibits the reaction [Bupivacaine results in decreased expression of BDNF mRNA] CTD PMID:35410500 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G CASP3 caspase 3 decreases expression
increases activity		 EXP
ISO		 Bupivacaine results in decreased expression of CASP3 protein
Bupivacaine results in increased activity of CASP3 protein		 CTD PMID:16109997 PMID:20194319 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP9 caspase 9 decreases expression EXP Bupivacaine results in decreased expression of CASP9 protein CTD PMID:20194319 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions ISO [Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of CYP3A9 mRNA CTD PMID:22341215 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998 		JBrowse link
G DNM1L dynamin 1 like decreases expression
multiple interactions		 ISO Bupivacaine results in decreased expression of DNM1L protein
HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of DNM1L protein]		 CTD PMID:34793778 NCBI chr12:32,679,301...32,745,650
Ensembl chr12:32,679,200...32,745,650 		JBrowse link
G ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 multiple interactions ISO [Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of ENTPD4 mRNA CTD PMID:22341215 NCBI chr 8:23,429,162...23,457,647
Ensembl chr 8:23,385,783...23,457,695 		JBrowse link
G H2AX H2A.X variant histone increases expression
multiple interactions		 ISO Bupivacaine results in increased expression of H2AX protein
Glucose promotes the reaction [Bupivacaine results in increased expression of H2AX protein]		 CTD PMID:31672611 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,874...119,095,465 		JBrowse link
G HPGDS hematopoietic prostaglandin D synthase increases expression ISO Bupivacaine results in increased expression of HPGDS mRNA; Bupivacaine results in increased expression of HPGDS protein CTD PMID:19359520 NCBI chr 4:94,298,535...94,342,836
Ensembl chr 4:94,298,535...94,342,876 		JBrowse link
G HRH1 histamine receptor H1 affects binding EXP HRH1 protein binds to Bupivacaine CTD PMID:32061592 NCBI chr 3:11,137,238...11,263,557
Ensembl chr 3:11,137,093...11,263,557 		JBrowse link
G HSPA12A heat shock protein family A (Hsp70) member 12A decreases expression
multiple interactions		 ISO Bupivacaine results in decreased expression of HSPA12A protein
HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of BCL2 protein]; HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of DNM1L protein]; HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of MFN1 protein]; HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of PINK1 protein]; HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of PPARGC1A protein]; HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of PRKN protein]; HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of SLC2A1 protein]; HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of SLC2A4 protein]; HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of TOMM20 protein]		 CTD PMID:34793778 NCBI chr10:116,671,192...116,850,747
Ensembl chr10:116,671,192...116,850,251 		JBrowse link
G ITGAM integrin subunit alpha M increases expression
multiple interactions		 ISO Bupivacaine results in increased expression of ITGAM mRNA
4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine inhibits the reaction [Bupivacaine results in increased expression of ITGAM mRNA]		 CTD PMID:19359520 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G KCNE1 potassium voltage-gated channel subfamily E regulatory subunit 1 multiple interactions EXP Bupivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]; KCNE1 protein inhibits the reaction [KCNQ1 protein mutant form results in increased susceptibility to Bupivacaine] CTD PMID:16931984 NCBI chr21:34,446,688...34,512,210
Ensembl chr21:34,446,688...34,512,214 		JBrowse link
G KCNK9 potassium two pore domain channel subfamily K member 9 multiple interactions EXP Bupivacaine inhibits the reaction [KCNK9 protein results in increased transport of Potassium] CTD PMID:11249964 NCBI chr 8:139,600,838...139,703,123
Ensembl chr 8:139,600,838...139,704,109 		JBrowse link
G KCNQ1 potassium voltage-gated channel subfamily Q member 1 multiple interactions
increases response to substance
decreases activity		 EXP Bupivacaine results in decreased activity of [KCNQ1 protein binds to KCNE1 protein]; KCNE1 protein inhibits the reaction [KCNQ1 protein mutant form results in increased susceptibility to Bupivacaine]
Bupivacaine results in decreased activity of KCNQ1 protein		 CTD PMID:16931984 NCBI chr11:2,445,008...2,849,105
Ensembl chr11:2,444,684...2,849,105 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP Glucose promotes the reaction [Bupivacaine results in increased phosphorylation of MAPK1 protein] CTD PMID:34060177 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP Bupivacaine results in increased phosphorylation of MAPK3 protein
Glucose promotes the reaction [Bupivacaine results in increased phosphorylation of MAPK3 protein]		 CTD PMID:34060177 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MFN1 mitofusin 1 decreases expression
multiple interactions		 ISO Bupivacaine results in decreased expression of MFN1 protein
HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of MFN1 protein]		 CTD PMID:34793778 NCBI chr 3:179,347,709...179,394,936
Ensembl chr 3:179,347,709...179,394,936 		JBrowse link
G MIR497 microRNA 497 multiple interactions
increases expression		 EXP MIR497 mRNA affects the reaction [Bupivacaine results in decreased expression of BDNF mRNA]; MIR497 mRNA inhibits the reaction [SNHG12 inhibits the reaction [Bupivacaine results in decreased expression of BDNF mRNA]]; MIR497 mRNA promotes the reaction [Bupivacaine results in decreased expression of NLRX1 mRNA]; NLRX1 protein affects the reaction [MIR497 mRNA affects the reaction [Bupivacaine results in decreased expression of BDNF mRNA]]; SNHG12 inhibits the reaction [Bupivacaine results in increased expression of MIR497 mRNA] CTD PMID:35410500 NCBI chr17:7,017,911...7,018,022
Ensembl chr17:7,017,911...7,018,022 		JBrowse link
G MYF5 myogenic factor 5 decreases expression ISO Bupivacaine results in decreased expression of MYF5 protein CTD PMID:10434046 NCBI chr12:80,716,912...80,719,671
Ensembl chr12:80,716,912...80,719,671 		JBrowse link
G MYOD1 myogenic differentiation 1 decreases expression ISO Bupivacaine results in decreased expression of MYOD1 protein CTD PMID:10434046 NCBI chr11:17,719,571...17,722,136
Ensembl chr11:17,719,571...17,722,136 		JBrowse link
G MYOG myogenin decreases expression ISO Bupivacaine results in decreased expression of MYOG protein CTD PMID:10434046 NCBI chr 1:203,083,129...203,086,012
Ensembl chr 1:203,083,129...203,086,012 		JBrowse link
G NLRX1 NLR family member X1 multiple interactions
decreases expression		 EXP MIR497 mRNA promotes the reaction [Bupivacaine results in decreased expression of NLRX1 mRNA]; NLRX1 protein affects the reaction [MIR497 mRNA affects the reaction [Bupivacaine results in decreased expression of BDNF mRNA]]; SNHG12 inhibits the reaction [Bupivacaine results in decreased expression of NLRX1 mRNA] CTD PMID:35410500 NCBI chr11:119,168,334...119,184,016
Ensembl chr11:119,166,568...119,184,016 		JBrowse link
G PINK1 PTEN induced kinase 1 multiple interactions
decreases expression		 ISO HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of PINK1 protein] CTD PMID:34793778 NCBI chr 1:20,633,458...20,651,511
Ensembl chr 1:20,633,458...20,651,511 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression
multiple interactions
decreases expression		 ISO Bupivacaine results in increased expression of PPARGC1A mRNA
HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of PPARGC1A protein]		 CTD PMID:34793778 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G PRKCB protein kinase C beta multiple interactions ISO [Bupivacaine co-treated with Tetrodotoxin co-treated with Dexamethasone] results in decreased expression of PRKCB mRNA CTD PMID:22341215 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611 		JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase multiple interactions
decreases expression		 ISO HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of PRKN protein] CTD PMID:34793778 NCBI chr 6:161,347,417...162,727,766
Ensembl chr 6:161,347,417...162,727,775 		JBrowse link
G PTGDR prostaglandin D2 receptor affects expression ISO Bupivacaine affects the expression of PTGDR mRNA CTD PMID:19359520 NCBI chr14:52,267,698...52,280,914
Ensembl chr14:52,267,698...52,276,724 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 increases expression EXP Bupivacaine results in increased expression of PTGS1 mRNA CTD PMID:18165598 NCBI chr 9:122,370,533...122,395,703
Ensembl chr 9:122,370,530...122,395,703 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP Bupivacaine results in increased expression of PTGS2 mRNA
[Bupivacaine results in increased expression of PTGS2] which results in increased abundance of Dinoprostone		 CTD PMID:18165598 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G SLC25A29 solute carrier family 25 member 29 multiple interactions
decreases activity		 ISO Emulsions inhibits the reaction [Bupivacaine results in decreased activity of SLC25A29 protein] CTD PMID:35135371 NCBI chr14:100,278,567...100,306,444
Ensembl chr14:100,291,116...100,306,547 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 multiple interactions
decreases expression		 ISO HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of SLC2A1 protein] CTD PMID:34793778 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 decreases expression
multiple interactions		 ISO Bupivacaine results in decreased expression of SLC2A4 protein
HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of SLC2A4 protein]		 CTD PMID:34793778 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G SLC6A2 solute carrier family 6 member 2 multiple interactions ISO Bupivacaine inhibits the reaction [[Desipramine results in decreased activity of SLC6A2 protein] which results in decreased abundance of Norepinephrine] CTD PMID:16725121 NCBI chr16:55,655,988...55,706,192
Ensembl chr16:55,655,988...55,707,645 		JBrowse link
G SNHG12 small nucleolar RNA host gene 12 multiple interactions
decreases expression		 EXP MIR497 mRNA inhibits the reaction [SNHG12 inhibits the reaction [Bupivacaine results in decreased expression of BDNF mRNA]]; SNHG12 inhibits the reaction [Bupivacaine results in decreased expression of BDNF mRNA]; SNHG12 inhibits the reaction [Bupivacaine results in decreased expression of NLRX1 mRNA]; SNHG12 inhibits the reaction [Bupivacaine results in increased expression of MIR497 mRNA]
Bupivacaine results in decreased expression of SNHG12 mRNA		 CTD PMID:35410500 NCBI chr 1:28,578,538...28,582,983
Ensembl chr 1:28,578,538...28,583,132 		JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 decreases expression
multiple interactions		 ISO Bupivacaine results in decreased expression of TOMM20 protein
HSPA12A protein inhibits the reaction [Bupivacaine results in decreased expression of TOMM20 protein]		 CTD PMID:34793778 NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837 		JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 increases activity
multiple interactions		 ISO Bupivacaine results in increased activity of TRPV1 protein
Bupivacaine affects the reaction [Capsaicin results in increased activity of TRPV1 protein]		 CTD PMID:15854744 PMID:18172555 NCBI chr17:3,565,446...3,609,411
Ensembl chr17:3,565,444...3,609,411 		JBrowse link
G XRCC6 X-ray repair cross complementing 6 increases expression
multiple interactions		 ISO Bupivacaine results in increased expression of XRCC6 protein
8-dibenzothiophen-4-yl-2-morpholin-4-yl-chromen-4-one inhibits the reaction [[Glucose co-treated with Bupivacaine] results in increased expression of XRCC6 protein]; [Glucose co-treated with Bupivacaine] results in increased expression of XRCC6 protein; Glucose inhibits the reaction [Bupivacaine results in increased expression of XRCC6 protein]		 CTD PMID:31672611 NCBI chr22:41,621,295...41,664,041
Ensembl chr22:41,621,163...41,664,048 		JBrowse link
levobupivacaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC25A29 solute carrier family 25 member 29 multiple interactions
decreases activity		 ISO Emulsions inhibits the reaction [Levobupivacaine results in decreased activity of SLC25A29 protein] CTD PMID:35135371 NCBI chr14:100,278,567...100,306,444
Ensembl chr14:100,291,116...100,306,547 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25922
    role 25837
      chemical role 24076
        emulsifier 5406
          surfactant 5406
            amphiphile 39
              9',9'-bis\{4-[bis(2-hydroxyethyl)amino]phenyl\}-9,9,9'',9''-tetrahexyl-9H,9'H,9''H-2,2':7',2''-terfluorene 0
              bupivacaine 39
              bupivacaine hydrochloride (anhydrous) + 0
              bupivacaine hydrochloride hydrate 0
              levobupivacaine + 39
              levobupivacaine hydrochloride (anhydrous) + 0
              levobupivacaine hydrochloride hydrate + 0
paths to the root