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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:21251946 |
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NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions increases expression |
EXP ISO |
dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein] dihydrolipoic acid results in increased expression of AKT1 protein dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein co-treated with Aluminum Hydroxide] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in increased expression of AKT1 protein] |
CTD |
PMID:21251946 PMID:37409350 |
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NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
ISO |
dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with Aluminum Hydroxide co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein co-treated with Aluminum Hydroxide] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]]; dihydrolipoic acid promotes the reaction [Aluminum Hydroxide inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]] |
CTD |
PMID:37409350 |
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NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
dihydrolipoic acid results in increased activity of CASP3 protein 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased activity of CASP3 protein] |
CTD |
PMID:21462292 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
increases activity multiple interactions |
ISO |
dihydrolipoic acid results in increased activity of CASP9 protein 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased activity of CASP9 protein] |
CTD |
PMID:21462292 |
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Ensembl chr 5:154,109,046...154,126,626
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [dihydrolipoic acid results in increased expression of CDKN1A mRNA] |
CTD |
PMID:21462292 |
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G |
Ctnnb1 |
catenin beta 1 |
multiple interactions decreases expression |
ISO |
dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with Aluminum Hydroxide co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in decreased expression of CTNNB1 protein] dihydrolipoic acid results in decreased expression of CTNNB1 protein |
CTD |
PMID:37409350 |
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NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
ISO |
[dihydrolipoic acid co-treated with toxoflavin] results in decreased activity of ERN1 protein |
CTD |
PMID:35840659 |
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NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases expression multiple interactions |
ISO |
dihydrolipoic acid results in increased expression of GSK3B protein dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in increased expression of GSK3B protein] |
CTD |
PMID:37409350 |
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NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
EXP |
[dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; dihydrolipoic acid results in increased expression of and results in increased activity of GSTP1 protein dihydrolipoic acid results in increased expression of GSTP1 mRNA |
CTD |
PMID:20237067 |
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NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases activity multiple interactions increases expression |
EXP |
dihydrolipoic acid results in increased activity of JUN protein [dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer] dihydrolipoic acid results in increased expression of JUN protein |
CTD |
PMID:20237067 |
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NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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G |
Map2 |
microtubule-associated protein 2 |
multiple interactions |
ISO |
dihydrolipoic acid inhibits the reaction [NGF protein results in increased expression of MAP2 protein] |
CTD |
PMID:21462292 |
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NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809
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G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
decreases phosphorylation |
EXP |
Dihydrolipoic acid decreases phosphorylation of Map3k7 protein in subarachnoid hemorrhage left cerebral hemisphere |
RGD |
PMID:29273596 |
RGD:155804269 |
NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:21251946 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21251946 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapt |
microtubule-associated protein tau |
multiple interactions decreases expression |
ISO |
dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]; dihydrolipoic acid promotes the reaction [Aluminum Hydroxide inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]] dihydrolipoic acid results in decreased expression of MAPT protein |
CTD |
PMID:37409350 |
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NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases activity increases expression |
EXP |
[dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer] dihydrolipoic acid results in increased activity of NFE2L2 protein dihydrolipoic acid results in increased expression of NFE2L2 protein |
CTD |
PMID:20237067 |
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NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G |
Ngf |
nerve growth factor |
multiple interactions |
ISO |
dihydrolipoic acid inhibits the reaction [NGF protein results in increased expression of MAP2 protein] |
CTD |
PMID:21462292 |
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NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
dihydrolipoic acid inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein] |
CTD |
PMID:18838692 |
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity |
ISO |
dihydrolipoic acid results in increased activity of NQO1 protein |
CTD |
PMID:18838692 |
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NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions decreases activity |
EXP |
dihydrolipoic acid affects the reaction [PDGFB protein results in increased abundance of Reactive Oxygen Species]; dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein] dihydrolipoic acid results in decreased activity of PDGFB protein |
CTD |
PMID:21251946 |
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NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
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G |
Ppp1ca |
protein phosphatase 1 catalytic subunit alpha |
multiple interactions |
ISO |
dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]] |
CTD |
PMID:37409350 |
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NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:201,485,085...201,497,327
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions |
EXP |
dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:21251946 |
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NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
dihydrolipoic acid affects the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21251946 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased expression of TRP53 mRNA]; Acetylcysteine inhibits the reaction [dihydrolipoic acid results in increased expression of TRP53 mRNA] |
CTD |
PMID:21462292 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G |
Wnt5a |
Wnt family member 5A |
multiple interactions increases expression |
ISO |
dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in decreased expression of WNT5A protein] dihydrolipoic acid results in increased expression of WNT5A protein |
CTD |
PMID:37409350 |
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NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234
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