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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:21251946 |
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NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
EXP |
dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:21251946 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
dihydrolipoic acid results in increased activity of CASP3 protein 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased activity of CASP3 protein] |
CTD |
PMID:21462292 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
increases activity multiple interactions |
ISO |
dihydrolipoic acid results in increased activity of CASP9 protein 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased activity of CASP9 protein] |
CTD |
PMID:21462292 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
multiple interactions increases expression |
ISO |
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [dihydrolipoic acid results in increased expression of CDKN1A mRNA] |
CTD |
PMID:21462292 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions increases expression |
EXP |
[dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; dihydrolipoic acid results in increased expression of and results in increased activity of GSTP1 protein dihydrolipoic acid results in increased expression of GSTP1 mRNA |
CTD |
PMID:20237067 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions increases expression increases activity |
EXP |
[dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer] dihydrolipoic acid results in increased expression of JUN protein dihydrolipoic acid results in increased activity of JUN protein |
CTD |
PMID:20237067 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Map2 |
microtubule-associated protein 2 |
multiple interactions |
ISO |
dihydrolipoic acid inhibits the reaction [NGF protein results in increased expression of MAP2 protein] |
CTD |
PMID:21462292 |
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NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
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G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
decreases phosphorylation |
EXP |
Dihydrolipoic acid decreases phosphorylation of Map3k7 protein in subarachnoid hemorrhage left cerebral hemisphere |
RGD |
PMID:29273596 |
RGD:155804269 |
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:21251946 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21251946 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions increases activity increases expression |
EXP |
[dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer] dihydrolipoic acid results in increased activity of NFE2L2 protein dihydrolipoic acid results in increased expression of NFE2L2 protein |
CTD |
PMID:20237067 |
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Ngf |
nerve growth factor |
multiple interactions |
ISO |
dihydrolipoic acid inhibits the reaction [NGF protein results in increased expression of MAP2 protein] |
CTD |
PMID:21462292 |
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NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
dihydrolipoic acid inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein] |
CTD |
PMID:18838692 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
increases activity |
ISO |
dihydrolipoic acid results in increased activity of NQO1 protein |
CTD |
PMID:18838692 |
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Pdgfb |
platelet derived growth factor subunit B |
multiple interactions decreases activity |
EXP |
dihydrolipoic acid affects the reaction [PDGFB protein results in increased abundance of Reactive Oxygen Species]; dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein] dihydrolipoic acid results in decreased activity of PDGFB protein |
CTD |
PMID:21251946 |
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NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions |
EXP |
dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein] |
CTD |
PMID:21251946 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
EXP |
dihydrolipoic acid affects the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:21251946 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased expression of TRP53 mRNA]; Acetylcysteine inhibits the reaction [dihydrolipoic acid results in increased expression of TRP53 mRNA] |
CTD |
PMID:21462292 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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