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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thio-fatty acid
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Accession:CHEBI:59913 term browser browse the term
Definition:Any fatty acid having at least one SH substituent.
Synonyms:related_synonym: mercapto-fatty acid;   mercapto-fatty acids;   sulfanyl fatty acid;   sulfanyl fatty acids;   thio-fatty acids
 cyclic_relationship: is_conjugate_acid_of CHEBI:59914



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dihydrolipoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] CTD PMID:21251946 NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases expression
EXP
ISO
dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]
dihydrolipoic acid results in increased expression of AKT1 protein
dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein co-treated with Aluminum Hydroxide] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in increased expression of AKT1 protein]
CTD PMID:21251946 PMID:37409350 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with Aluminum Hydroxide co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein co-treated with Aluminum Hydroxide] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of AKT1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]]; dihydrolipoic acid promotes the reaction [Aluminum Hydroxide inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]] CTD PMID:37409350 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
ISO dihydrolipoic acid results in increased activity of CASP3 protein
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased activity of CASP3 protein]
CTD PMID:21462292 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity
multiple interactions
ISO dihydrolipoic acid results in increased activity of CASP9 protein
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased activity of CASP9 protein]
CTD PMID:21462292 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased expression of CDKN1A mRNA]; Acetylcysteine inhibits the reaction [dihydrolipoic acid results in increased expression of CDKN1A mRNA] CTD PMID:21462292 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with Aluminum Hydroxide co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of CTNNB1 protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in decreased expression of CTNNB1 protein]
dihydrolipoic acid results in decreased expression of CTNNB1 protein
CTD PMID:37409350 NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO [dihydrolipoic acid co-treated with toxoflavin] results in decreased activity of ERN1 protein CTD PMID:35840659 NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression
multiple interactions
ISO dihydrolipoic acid results in increased expression of GSK3B protein
dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of GSK3B protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in increased expression of GSK3B protein]
CTD PMID:37409350 NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP [dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]; dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; dihydrolipoic acid results in increased expression of and results in increased activity of GSTP1 protein
dihydrolipoic acid results in increased expression of GSTP1 mRNA
CTD PMID:20237067 NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases activity
multiple interactions
increases expression
EXP dihydrolipoic acid results in increased activity of JUN protein
[dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; dihydrolipoic acid promotes the reaction [JUN protein binds to GSTP1 enhancer]
dihydrolipoic acid results in increased expression of JUN protein
CTD PMID:20237067 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions ISO dihydrolipoic acid inhibits the reaction [NGF protein results in increased expression of MAP2 protein] CTD PMID:21462292 NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 decreases phosphorylation EXP Dihydrolipoic acid decreases phosphorylation of Map3k7 protein in subarachnoid hemorrhage left cerebral hemisphere RGD PMID:29273596 RGD:155804269 NCBI chr 5:51,149,524...51,212,012
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein] CTD PMID:21251946 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:21251946 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions
decreases expression
ISO dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]; dihydrolipoic acid promotes the reaction [Aluminum Hydroxide inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in increased expression of MAPT protein]]
dihydrolipoic acid results in decreased expression of MAPT protein
CTD PMID:37409350 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity
increases expression
EXP [dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; dihydrolipoic acid promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]
dihydrolipoic acid results in increased activity of NFE2L2 protein
dihydrolipoic acid results in increased expression of NFE2L2 protein
CTD PMID:20237067 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngf nerve growth factor multiple interactions ISO dihydrolipoic acid inhibits the reaction [NGF protein results in increased expression of MAP2 protein] CTD PMID:21462292 NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO dihydrolipoic acid inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein] CTD PMID:18838692 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases activity ISO dihydrolipoic acid results in increased activity of NQO1 protein CTD PMID:18838692 NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions
decreases activity
EXP dihydrolipoic acid affects the reaction [PDGFB protein results in increased abundance of Reactive Oxygen Species]; dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]; dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein]
dihydrolipoic acid results in decreased activity of PDGFB protein
CTD PMID:21251946 NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Ppp1ca protein phosphatase 1 catalytic subunit alpha multiple interactions ISO dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of PPP1CA protein]] CTD PMID:37409350 NCBI chr 1:210,914,576...210,918,193
Ensembl chr 1:201,485,085...201,497,327
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP dihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein] CTD PMID:21251946 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP dihydrolipoic acid affects the reaction [TGFB1 protein results in increased abundance of Reactive Oxygen Species]; dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK1 protein]; dihydrolipoic acid inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:21251946 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide inhibits the reaction [dihydrolipoic acid results in increased expression of TRP53 mRNA]; Acetylcysteine inhibits the reaction [dihydrolipoic acid results in increased expression of TRP53 mRNA] CTD PMID:21462292 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Wnt5a Wnt family member 5A multiple interactions
increases expression
ISO dihydrolipoic acid inhibits the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide promotes the reaction [[Tretinoin co-treated with BDNF protein] results in decreased expression of WNT5A protein]]; dihydrolipoic acid inhibits the reaction [Aluminum Hydroxide results in decreased expression of WNT5A protein]
dihydrolipoic acid results in increased expression of WNT5A protein
CTD PMID:37409350 NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19899
    chemical entity 19897
      atom 19897
        nonmetal atom 19820
          sulfur atom 17780
            sulfur molecular entity 17780
              organosulfur compound 17475
                sulfur-containing carboxylic acid 6665
                  thio-fatty acid 26
                    dihydrolipoic acid + 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19899
    subatomic particle 19897
      composite particle 19897
        hadron 19897
          baryon 19897
            nucleon 19897
              atomic nucleus 19897
                atom 19897
                  main group element atom 19836
                    p-block element atom 19836
                      carbon group element atom 19776
                        carbon atom 19772
                          organic molecular entity 19772
                            heteroorganic entity 19537
                              organochalcogen compound 19297
                                organooxygen compound 19215
                                  carbon oxoacid 18693
                                    carboxylic acid 18690
                                      monocarboxylic acid 18028
                                        fatty acid 16861
                                          thio-fatty acid 26
                                            dihydrolipoic acid + 26
paths to the root