Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:HIV fusion inhibitor
go back to main search page
Accession:CHEBI:59886 term browser browse the term
Definition:A drug which interferes with the binding, fusion and entry of an HIV virion to a human cell. By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS.
Synonyms:related_synonym: HIV entry inhibitor;   HIV entry inhibitors;   HIV fusion inhibitors
 xref: PMID:22470838;   Wikipedia:Entry_inhibitor


show annotations for term's descendants           Sort by:
 
enfuvirtide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects activity ISO enfuvirtide affects the activity of CYP1A2 protein CTD PMID:15656696 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 affects activity ISO enfuvirtide affects the activity of CYP2C19 protein CTD PMID:15656696 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects activity ISO enfuvirtide affects the activity of CYP2E1 protein CTD PMID:15656696 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
maraviroc term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn2 actinin alpha 2 multiple interactions EXP [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 mRNA; [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 protein CTD PMID:31023824 NCBI chr13:12,269,426...12,340,732
Ensembl chr13:12,269,426...12,340,760
JBrowse link
G Ccl3 chemokine (C-C motif) ligand 3 multiple interactions ISO maraviroc inhibits the reaction [CCL3 protein binds to CCR5 protein] CTD PMID:15644495 NCBI chr11:83,647,843...83,649,378
Ensembl chr11:83,647,844...83,649,355
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 multiple interactions ISO maraviroc inhibits the reaction [CCL5 protein binds to CCR5 protein] CTD PMID:15644495 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccr5 chemokine (C-C motif) receptor 5 multiple interactions ISO maraviroc binds to and results in decreased activity of CCR5 protein; maraviroc inhibits the reaction [CCL3 protein binds to CCR5 protein]; maraviroc inhibits the reaction [CCL5 protein binds to CCR5 protein] CTD PMID:15644495 PMID:21128663 NCBI chr 9:124,121,543...124,127,183
Ensembl chr 9:124,121,543...124,147,699
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions EXP [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in decreased expression of COL1A1 mRNA CTD PMID:31023824 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col1a2 collagen, type I, alpha 2 multiple interactions EXP [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in decreased expression of COL1A2 mRNA CTD PMID:31023824 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha multiple interactions EXP [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of MYH6 mRNA CTD PMID:31023824 NCBI chr14:54,941,921...54,968,017
Ensembl chr14:54,941,921...54,966,927
JBrowse link
G Ryr2 ryanodine receptor 2, cardiac multiple interactions EXP [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of RYR2 mRNA CTD PMID:31023824 NCBI chr13:11,553,099...12,106,945
Ensembl chr13:11,553,102...12,106,945
JBrowse link
G Tnnt2 troponin T2, cardiac multiple interactions EXP [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of TNNT2 mRNA; [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of TNNT2 protein CTD PMID:31023824 NCBI chr 1:135,836,315...135,852,268
Ensembl chr 1:135,836,354...135,852,260
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21788
    role 21767
      biological role 21765
        antimicrobial agent 18388
          antiviral agent 10582
            antiviral drug 1848
              HIV fusion inhibitor 12
                enfuvirtide 3
                maraviroc 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 21788
    role 21767
      application 21279
        pharmaceutical 20744
          drug 20744
            antiinfective agent 14551
              antimicrobial drug 8815
                antiviral drug 1848
                  HIV fusion inhibitor 12
                    enfuvirtide 3
                    maraviroc 9
paths to the root