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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:HIV fusion inhibitor
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Accession:CHEBI:59886 term browser browse the term
Definition:A drug which interferes with the binding, fusion and entry of an HIV virion to a human cell. By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS.
Synonyms:related_synonym: HIV entry inhibitor;   HIV entry inhibitors;   HIV fusion inhibitors
 xref: PMID:22470838;   Wikipedia:Entry_inhibitor



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enfuvirtide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects activity EXP enfuvirtide affects the activity of CYP1A2 protein CTD PMID:15656696 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 affects activity EXP enfuvirtide affects the activity of CYP2C19 protein CTD PMID:15656696 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects activity EXP enfuvirtide affects the activity of CYP2E1 protein CTD PMID:15656696 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
maraviroc term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTN2 actinin alpha 2 multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 mRNA; [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 protein CTD PMID:31023824 NCBI chr 1:236,686,499...236,764,631
Ensembl chr 1:236,664,141...236,764,631
JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions EXP maraviroc inhibits the reaction [CCL3 protein binds to CCR5 protein] CTD PMID:15644495 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions EXP maraviroc inhibits the reaction [CCL5 protein binds to CCR5 protein] CTD PMID:15644495 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCR5 C-C motif chemokine receptor 5 multiple interactions EXP maraviroc binds to and results in decreased activity of CCR5 protein; maraviroc inhibits the reaction [CCL3 protein binds to CCR5 protein]; maraviroc inhibits the reaction [CCL5 protein binds to CCR5 protein] CTD PMID:15644495 PMID:21128663 NCBI chr 3:46,370,142...46,376,206
Ensembl chr 3:46,370,854...46,376,206
JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in decreased expression of COL1A1 mRNA CTD PMID:31023824 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,184,101...50,201,632
JBrowse link
G COL1A2 collagen type I alpha 2 chain multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in decreased expression of COL1A2 mRNA CTD PMID:31023824 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G MYH6 myosin heavy chain 6 multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of MYH6 mRNA CTD PMID:31023824 NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273
JBrowse link
G RYR2 ryanodine receptor 2 multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of RYR2 mRNA CTD PMID:31023824 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988
JBrowse link
G TNNT2 troponin T2, cardiac type multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of TNNT2 mRNA; [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of TNNT2 protein CTD PMID:31023824 NCBI chr 1:201,359,014...201,377,828
Ensembl chr 1:201,359,008...201,377,764
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24839
    role 24759
      biological role 24728
        antimicrobial agent 20622
          antiviral agent 10791
            antiviral drug 1883
              HIV fusion inhibitor 12
                enfuvirtide 3
                maraviroc 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 24839
    role 24759
      application 23907
        pharmaceutical 23504
          drug 23504
            antiinfective agent 15374
              antimicrobial drug 9072
                antiviral drug 1883
                  HIV fusion inhibitor 12
                    enfuvirtide 3
                    maraviroc 9
paths to the root