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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:HIV fusion inhibitor
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Accession:CHEBI:59886 term browser browse the term
Definition:A drug which interferes with the binding, fusion and entry of an HIV virion to a human cell. By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS.
Synonyms:related_synonym: HIV entry inhibitor;   HIV entry inhibitors;   HIV fusion inhibitors
 xref: PMID:22470838;   Wikipedia:Entry_inhibitor


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enfuvirtide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects activity ISO enfuvirtide affects the activity of CYP1A2 protein CTD PMID:15656696 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 affects activity ISO enfuvirtide affects the activity of CYP2C19 protein CTD PMID:15656696 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 affects activity ISO enfuvirtide affects the activity of CYP2E1 protein CTD PMID:15656696 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
maraviroc term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn2 actinin alpha 2 multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 mRNA; [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of ACTN2 protein CTD PMID:31023824 NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO maraviroc inhibits the reaction [CCL3 protein binds to CCR5 protein] CTD PMID:15644495 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO maraviroc inhibits the reaction [CCL5 protein binds to CCR5 protein] CTD PMID:15644495 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO maraviroc binds to and results in decreased activity of CCR5 protein; maraviroc inhibits the reaction [CCL3 protein binds to CCR5 protein]; maraviroc inhibits the reaction [CCL5 protein binds to CCR5 protein] CTD PMID:15644495 PMID:21128663 NCBI chr 8:133,192,398...133,215,599
Ensembl chr 8:133,197,032...133,215,614
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in decreased expression of COL1A1 mRNA CTD PMID:31023824 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in decreased expression of COL1A2 mRNA CTD PMID:31023824 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of MYH6 mRNA CTD PMID:31023824 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of RYR2 mRNA CTD PMID:31023824 NCBI chr17:65,533,998...65,955,606
Ensembl chr17:65,535,403...65,955,606
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions ISO [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of TNNT2 mRNA; [BX 471 co-treated with C 021 compound co-treated with Maraviroc] results in increased expression of TNNT2 protein CTD PMID:31023824 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        antimicrobial agent 17376
          antiviral agent 10296
            antiviral drug 1850
              HIV fusion inhibitor 12
                enfuvirtide 3
                maraviroc 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      application 19403
        pharmaceutical 19303
          drug 19303
            antiinfective agent 13454
              antimicrobial drug 6237
                antiviral drug 1850
                  HIV fusion inhibitor 12
                    enfuvirtide 3
                    maraviroc 9
paths to the root