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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:depigmentation drug
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Accession:CHEBI:59864 term browser browse the term
Definition:Any drug used to depigment skin, normally by decreasing the excretion of melanin from melanocytes.
Synonyms:related_synonym: depigmentation agent;   depigmentation agents;   depigmentation drugs;   depigmentor;   depigmentors


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fucoidan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO fucoidan results in decreased expression of BIRC2 protein CTD PMID:16201850 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO fucoidan results in decreased expression of BIRC5 protein CTD PMID:16201850 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO fucoidan results in decreased expression of CCL5 protein CTD PMID:16201850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO fucoidan results in decreased expression of CCND2 protein CTD PMID:16201850 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO fucoidan results in increased expression of CDKN1A CTD PMID:24333868 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Gast gastrin multiple interactions EXP fucoidan analog inhibits the reaction [Cisplatin results in decreased expression of GAST protein] CTD PMID:23022014 NCBI chr10:88,245,532...88,248,485
Ensembl chr10:88,245,532...88,248,484
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP fucoidan inhibits the reaction [Aspirin results in increased expression of GPT protein] CTD PMID:19788892 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Ifng interferon gamma multiple interactions EXP fucoidan promotes the reaction [Aspirin results in increased expression of IFNG protein] CTD PMID:19788892 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il10 interleukin 10 multiple interactions EXP fucoidan promotes the reaction [Aspirin results in increased expression of IL10 protein] CTD PMID:19788892 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO fucoidan inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein] CTD PMID:16364234 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP fucoidan inhibits the reaction [Aspirin results in increased expression of IL6 protein] CTD PMID:19788892 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit decreases activity ISO fucoidan results in decreased activity of JUND protein CTD PMID:16201850 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases secretion ISO fucoidan results in decreased secretion of MMP2 protein CTD PMID:16364234 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO fucoidan inhibits the reaction [IL1B protein results in increased secretion of MMP3 protein] CTD PMID:16364234 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO fucoidan results in decreased expression of MMP9
wortmannin inhibits the reaction [fucoidan results in decreased expression of MMP9]
CTD PMID:24333868 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP
ISO
fucoidan inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:15138204, PMID:18209962 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO fucoidan results in decreased expression of MYC protein CTD PMID:16201850 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases activity ISO fucoidan results in decreased activity of NFKB1 protein CTD PMID:16201850 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO fucoidan inhibits the reaction [Nanotubes, Carbon inhibits the reaction [endotoxin, Escherichia coli results in increased expression of PTGS2 protein]] CTD PMID:17709331 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO fucoidan results in decreased expression of RB1 protein CTD PMID:16201850 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rel REL proto-oncogene, NF-kB subunit decreases activity ISO fucoidan results in decreased activity of REL protein CTD PMID:16201850 NCBI chr14:108,490,794...108,517,582
Ensembl chr14:108,491,069...108,509,892
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases activity ISO fucoidan results in decreased activity of RELA protein CTD PMID:16201850 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases secretion ISO fucoidan results in decreased secretion of TIMP1 protein CTD PMID:16364234 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
geranic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tyr tyrosinase decreases expression ISO decaprenoic acid results in decreased expression of TYR protein CTD PMID:23286867 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
monobenzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP monobenzone binds to AFP protein CTD PMID:23013281 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Ar androgen receptor affects binding EXP monobenzone binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO monobenzone results in increased activity of NR1I2 protein
[monobenzone results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO monobenzone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19792
    role 19738
      application 19385
        pharmaceutical 19255
          drug 19255
            depigmentation drug 28
              melanin synthesis inhibitor + 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.