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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:isoalantolactone
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Accession:CHEBI:5981 term browser browse the term
Definition:A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium.
Synonyms:exact_synonym: (3aR,4aS,8aR,9aR)-8a-methyl-3,5-bis(methylidene)decahydronaphtho[2,3-b]furan-2(3H)-one;   eudesma-4(14),11(13)-dieno-12,8beta-olactone
 related_synonym: 8beta-hydroxyeudesma-4(14),11(13)-dien-12-oic acid gamma-lactone;   Formula=C15H20O2;   InChI=1S/C15H20O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h11-13H,1-2,4-8H2,3H3/t11-,12+,13-,15-/m1/s1;   InChIKey=CVUANYCQTOGILD-QVHKTLOISA-N;   SMILES=[H][C@@]12C[C@@]3(C)CCCC(=C)[C@]3([H])C[C@]1([H])C(=C)C(=O)O2;   iso-alantolacton
 alt_id: CHEBI:325864
 xref: CAS:470-17-7;   HMDB:HMDB0035934;   KEGG:C09484;   KNApSAcK:C00003306
 xref_mesh: MESH:C032787
 xref: PMID:1444579;   PMID:20658657;   PMID:22532787;   PMID:22799093;   PMID:23881702;   PMID:24520052;   Reaxys:13402


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isoalantolactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression ISO isoalantolactone results in increased expression of CASP3 protein modified form CTD PMID:29800641 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage
multiple interactions
increases expression		 ISO isoalantolactone results in increased cleavage of CASP7 protein
Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]; TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of CASP7 protein modified form]		 CTD PMID:29800641 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression
increases cleavage
multiple interactions		 ISO isoalantolactone results in increased expression of PARP1 protein modified form
isoalantolactone results in increased cleavage of PARP1 protein
Acetylcysteine inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]; TNFRSF10B protein promotes the reaction [isoalantolactone results in increased expression of PARP1 protein modified form]		 CTD PMID:29800641 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        antimicrobial agent 17941
          antifungal agent 16378
            isoalantolactone 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic group 18902
                              organic divalent group 18884
                                organodiyl group 18884
                                  carbonyl group 18850
                                    carbonyl compound 18850
                                      carboxylic ester 16000
                                        lactone 11444
                                          terpene lactone 2155
                                            sesquiterpene lactone 2015
                                              isoalantolactone 3
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