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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diphenylpyraline
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Accession:CHEBI:59788 term browser browse the term
Definition:A member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.
Synonyms:exact_synonym: 4-(diphenylmethoxy)-1-methylpiperidine
 related_synonym: 1-methyl-4-hydroxypiperidine benzhydryl ether;   1-methyl-4-piperidyl benzhydryl ether;   4-(benzhydryloxy)-1-methylpiperidine;   4-(benzhydryloxy)-N-methylpiperidine;   Formula=C19H23NO;   InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3;   InChIKey=OWQUZNMMYNAXSL-UHFFFAOYSA-N;   SMILES=CN1CCC(CC1)OC(c1ccccc1)c1ccccc1;   difenilpiralina;   diphenylpyralamine;   diphenylpyralinum
 xref: Beilstein:245467;   CAS:147-20-6;   DrugBank:DB01146;   Drug_Central:920;   HMDB:HMDB0015277;   KEGG:D07862;   LINCS:LSM-5385
 xref_mesh: MESH:C009871
 xref: PMID:14039;   PMID:15627433;   PMID:22445882;   Patent:US2479843;   Reaxys:245467;   Wikipedia:Diphenylpyraline


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diphenylpyraline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO diphenylpyraline binds to and results in increased activity of HRH1 protein; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:1912125 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO diphenylpyraline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    role 19790
      biological role 19790
        pharmacological role 18841
          antagonist 16284
            histamine antagonist 4604
              H1-receptor antagonist 4100
                diphenylpyraline 2
                  diphenylpyraline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    main group molecular entity 19730
                      s-block molecular entity 19481
                        hydrogen molecular entity 19473
                          hydrides 18743
                            inorganic hydride 17482
                              pnictogen hydride 17455
                                nitrogen hydride 17300
                                  azane 17019
                                    ammonia 17018
                                      organic amino compound 17017
                                        tertiary amino compound 8645
                                          tertiary amine 618
                                            diphenylpyraline 2
                                              diphenylpyraline hydrochloride 0
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