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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diphenylpyraline
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Accession:CHEBI:59788 term browser browse the term
Definition:A member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.
Synonyms:exact_synonym: 4-(diphenylmethoxy)-1-methylpiperidine
 related_synonym: 1-methyl-4-hydroxypiperidine benzhydryl ether;   1-methyl-4-piperidyl benzhydryl ether;   4-(benzhydryloxy)-1-methylpiperidine;   4-(benzhydryloxy)-N-methylpiperidine;   Formula=C19H23NO;   InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3;   InChIKey=OWQUZNMMYNAXSL-UHFFFAOYSA-N;   SMILES=CN1CCC(CC1)OC(c1ccccc1)c1ccccc1;   difenilpiralina;   diphenylpyralamine;   diphenylpyralinum
 xref: Beilstein:245467;   CAS:147-20-6;   DrugBank:DB01146;   Drug_Central:920;   HMDB:HMDB0015277;   KEGG:D07862;   LINCS:LSM-5385
 xref_mesh: MESH:C009871
 xref: PMID:14039;   PMID:15627433;   PMID:22445882;   Patent:US2479843;   Reaxys:245467;   Wikipedia:Diphenylpyraline


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diphenylpyraline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO diphenylpyraline binds to and results in increased activity of HRH1 protein; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:1912125 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO diphenylpyraline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19908
    role 19883
      biological role 19881
        pharmacological role 19101
          antagonist 17168
            histamine antagonist 4888
              H1-receptor antagonist 4140
                diphenylpyraline 2
                  diphenylpyraline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19908
    subatomic particle 19906
      composite particle 19906
        hadron 19906
          baryon 19906
            nucleon 19906
              atomic nucleus 19906
                atom 19906
                  main group element atom 19853
                    main group molecular entity 19853
                      s-block molecular entity 19684
                        hydrogen molecular entity 19673
                          hydrides 19150
                            inorganic hydride 18129
                              pnictogen hydride 18118
                                nitrogen hydride 18024
                                  azane 17823
                                    ammonia 17822
                                      organic amino compound 17822
                                        tertiary amino compound 10136
                                          tertiary amine 634
                                            diphenylpyraline 2
                                              diphenylpyraline hydrochloride 0
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