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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diphenylpyraline
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Accession:CHEBI:59788 term browser browse the term
Definition:A member of the class of piperidines that is the benzhydryl ether derivative of 1-methyl-4-hydroxypiperidine. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders. It is also used as the teoclate salt (piprinhydrinate) as an ingredient in compound preparations for the symptomatic relief of coughs and the common cold.
Synonyms:exact_synonym: 4-(diphenylmethoxy)-1-methylpiperidine
 related_synonym: 1-methyl-4-hydroxypiperidine benzhydryl ether;   1-methyl-4-piperidyl benzhydryl ether;   4-(benzhydryloxy)-1-methylpiperidine;   4-(benzhydryloxy)-N-methylpiperidine;   Formula=C19H23NO;   InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3;   InChIKey=OWQUZNMMYNAXSL-UHFFFAOYSA-N;   SMILES=CN1CCC(CC1)OC(c1ccccc1)c1ccccc1;   difenilpiralina;   diphenylpyralamine;   diphenylpyralinum
 xref: Beilstein:245467;   CAS:147-20-6;   DrugBank:DB01146;   Drug_Central:920;   HMDB:HMDB0015277;   KEGG:D07862;   LINCS:LSM-5385
 xref_mesh: MESH:C009871
 xref: PMID:14039;   PMID:15627433;   PMID:22445882;   Patent:US2479843;   Reaxys:245467;   Wikipedia:Diphenylpyraline



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diphenylpyraline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO diphenylpyraline binds to and results in increased activity of HRH1 protein; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:1912125 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO diphenylpyraline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        pharmacological role 19087
          antagonist 16715
            histamine antagonist 4857
              H1-receptor antagonist 4123
                diphenylpyraline 2
                  diphenylpyraline hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        tertiary amino compound 8848
                                          tertiary amine 627
                                            diphenylpyraline 2
                                              diphenylpyraline hydrochloride 0
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