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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:2-hydroxy-4-methylvaleric acid
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Accession:CHEBI:59783 term browser browse the term
Definition:A valeric acid derivative having a hydroxy substituent at the 2-position and a methyl substituent at the 4-position; an alpha-hydroxy analogue of leucine. A bacterial metabolite, it has also been isolated from amniotic fluid, was found in a patient with dihydrolipoyl dehydrogenase deficiency and is present in the urine of patients with short bowel syndrome.
Synonyms:related_synonym: 2-Hydroxy-4-methylpentanoic acid;   2-hydroxyisocaproic acid;   2-hydroxyisohexanoic acid;   Formula=C6H12O3;   InChI=1S/C6H12O3/c1-4(2)3-5(7)6(8)9/h4-5,7H,3H2,1-2H3,(H,8,9);   InChIKey=LVRFTAZAXQPQHI-UHFFFAOYSA-N;   Leucic acid;   SMILES=C(C(C(O)=O)O)C(C)C;   alpha-Hydroxyisocaproic acid;   leucinic acid
 xref: CAS:498-36-2;   HMDB:HMDB0000665;   LIPID_MAPS_instance:LMFA01050381
 xref_mesh: MESH:C019419
 xref: PMID:17439666;   PMID:4018104;   PMID:6467607;   PMID:6688766;   Reaxys:1721733
 cyclic_relationship: is_conjugate_acid_of CHEBI:133577


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2-hydroxy-4-methylvaleric acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of alpha-hydroxyisocaproic acid CTD PMID:20567778 NCBI chr 4:101,574,393...101,676,375
Ensembl chr 4:101,574,601...101,672,549 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22194
    role 22179
      biological role 22178
        biochemical role 21449
          metabolite 21397
            2-hydroxy-4-methylvaleric acid 1
              (R)-2-hydroxy-4-methylpentanoic acid + 0
              (S)-2-hydroxy-4-methylpentanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22194
    subatomic particle 22186
      composite particle 22186
        hadron 22186
          baryon 22186
            nucleon 22186
              atomic nucleus 22186
                atom 22186
                  main group element atom 22120
                    p-block element atom 22120
                      carbon group element atom 21920
                        carbon atom 21846
                          organic molecular entity 21846
                            heteroorganic entity 21500
                              organochalcogen compound 20983
                                organooxygen compound 20824
                                  carbon oxoacid 19606
                                    carboxylic acid 19602
                                      monocarboxylic acid 18969
                                        fatty acid 17131
                                          saturated fatty acid 16850
                                            straight-chain saturated fatty acid 16274
                                              valeric acid 14814
                                                2-hydroxy-4-methylvaleric acid 1
                                                  (R)-2-hydroxy-4-methylpentanoic acid + 0
                                                  (S)-2-hydroxy-4-methylpentanoic acid 0
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