Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diflorasone
go back to main search page
Accession:CHEBI:59750 term browser browse the term
Definition:The 16beta-analogue of flumethasone. It is used as the 17,21-diacetate as a topical anti-inflammatory and antipruritic in the treatment of various skin disorders.
Synonyms:exact_synonym: 6alpha,9-difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione
 related_synonym: (6alpha,11beta,16beta)-6,9-difluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;   Formula=C22H28F2O5;   InChI=1S/C22H28F2O5/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-19(15,2)21(14,24)17(27)9-20(13,3)22(11,29)18(28)10-25/h4-5,7,11,13-14,16-17,25,27,29H,6,8-10H2,1-3H3/t11-,13-,14-,16-,17-,19-,20-,21-,22-/m0/s1;   InChIKey=WXURHACBFYSXBI-XHIJKXOTSA-N;   SMILES=[H][C@@]12C[C@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C;   diflorasona;   diflorasonum
 xref: Beilstein:5645455;   CAS:2557-49-5;   DrugBank:DB00223;   KEGG:D07827
 xref_mesh: MESH:C014477
 xref: Patent:GB881334;   Patent:GB898293;   Patent:GB912015;   Patent:US3557158;   Wikipedia:Diflorasone



show annotations for term's descendants           Sort by:
 
diflorasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL17 C-C motif chemokine ligand 17 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL17 protein]; diflorasone promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL17 protein] CTD PMID:15491423 NCBI chr16:57,396,093...57,416,063
Ensembl chr16:57,404,767...57,416,063
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions ISO diflorasone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL5 protein]; diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CCL5 protein] CTD PMID:15491423 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of CXCL2 protein] CTD PMID:12956900 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G IL4 interleukin 4 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL4 protein] CTD PMID:12956900 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions ISO diflorasone inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL6 protein] CTD PMID:12956900 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25458
    role 25399
      application 24570
        anti-inflammatory agent 17651
          anti-inflammatory drug 15733
            diflorasone 5
              diflorasone diacetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 25458
    subatomic particle 25427
      composite particle 25433
        hadron 25427
          baryon 25427
            nucleon 25427
              atomic nucleus 25427
                atom 25427
                  main group element atom 25279
                    p-block element atom 25279
                      carbon group element atom 24839
                        carbon atom 24821
                          organic molecular entity 24815
                            organic group 22985
                              organic divalent group 22963
                                organodiyl group 22963
                                  carbonyl group 22957
                                    carbonyl compound 22957
                                      ketone 19287
                                        oxyketone 9304
                                          alpha-oxyketone 9304
                                            alpha-hydroxy ketone 9308
                                              primary alpha-hydroxy ketone 8148
                                                diflorasone 5
                                                  diflorasone diacetate 0
paths to the root